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MCB 407 – Immunology and Immunochemistry COURSE PARTICULARS COURSE INSTRUCTORS COURSE DESCRIPTION

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MCB 407 – Immunology and Immunochemistry COURSE PARTICULARS COURSE INSTRUCTORS COURSE DESCRIPTION D DEPARTMENT OF MICROBIOLOGY MCB 407 – Immunology and Immunochemistry COURSE PARTICULARS Course Code: MCB 407 Course Title: Immunology and Immunochemistry No. of Units: 4 Course Duration: Three hours of theory and three hours of practical per week for 15 weeks. Status: Compulsory Course Email Address: [email protected] Course Webpage: http://www.fwt.futa.edu.ng/courseschedule.php?coursecode=MCB%407 Prerequisite: BIO 201, BCH 201 COURSE INSTRUCTORS Professor (Mrs). T. T. Adebolu Microbiology Office Annex, Room 14 Dept. of Microbiology, Federal University of Technology, Akure, Nigeria. Phone: +2348053617571 Email: [email protected] and Dr. M. K. Oladunmoye Postgraduate Research Laboratory Phase 1, Dept. of Microbiology, Federal University of Technology, Akure, Nigeria. Phone: +2348035057977 Email: [email protected] COURSE DESCRIPTION Basic concept of Immunology. Antigens and antigenic determinants. Antibodies. Structures and classification of immunoglobulins/antibodies. Antigen and antibody reactions. Innate and Acquired Immunity. Immune response. Hypersensitivity reactions. Autoimmune diseases. Immunodeficiency diseases. Introduction to transplantation immunology. The practicals will include laboratory exercise in modern techniques in immunology and immunochemistry. 1 COURSE OBJECTIVES The objectives of this course are to: give the students an insight to the basic concept of immunology; expose the students to the major determinants that confer immunity in a host to infections; and acquire practical skills for immunodiagnosis of infectious diseases. COURSE LEARNING OUTCOMES / COMPETENCIES Upon successful completion of this course, the student will be able to: (Knowledge based) discuss the basic principle underlining body response to foreign agents; understand the purpose and function of antibodies and other molecules involved in resistance to infection; explain the major ways antigens and antibodies interact; know the mechanism of antibody formation and genetic basis of their synthesis; and understand the various diseases associated with immunodeficiency disorders and autoimmunity. understand the rejection phenomenon in transplantation immunology. (Skills) use serological techniques in diagnosis of diseases and detection of contaminants in non clinical samples and acquire skill in immunoprophylaxis and serotherapeutic techniques in treating infections. GRADING SYSTEM FOR THE COURSE This course will be graded as follows: Class Attendance 10% Assignments 10% Practical 10% Test 10% Final Examination 60% TOTAL 100% 2 GENERAL INSTRUCTIONS Attendance: It is expected that every student will be in class for lectures and also participate in all practical exercises. Attendance records will be kept and used to determine each person’s qualification to sit for the final examination. In case of illness or other unavoidable cause of absence, the student must communicate as soon as possible with any of the instructors, indicating the reason for the absence. Lateness to class will not be condoned. Academic Integrity: Violations of academic integrity, including dishonesty in assignments, examinations, or other academic performances are prohibited. You are not allowed to make copies of another person’s work and submit it as your own; that is plagiarism. All cases of academic dishonesty will be reported to the University Management for appropriate sanctions in accordance with the guidelines for handling students’ misconduct as spelt out in the Students’ Handbook. Assignments and Group Work: Students are expected to submit assignments as scheduled. Failure to submit an assignment as and when due will earn you zero for that assignment. Only under extenuating circumstances, for which a student has notified any of the instructors in advance, will late submission of assignments be permitted. Code of Conduct in Lecture Rooms and Laboratories: Students should turn off their cell phones during lectures. Students are prohibited from engaging in other activities (listening to music and watching videos, etc.) during lectures. Eating, snacking or chewing gum is not permitted when the class is going on or during practical sessions. Students should dress decently and wearing of Laboratory coat is compulsory during practicals. READING LIST 1,2 Tortora, G. J., Funke, B. R., and Case, C. L. (2007). Microbiology: An Introduction. Pearson Publishers, 9th edition. 1,2 ,5 Willey, J. M., Sherwood, L. M., and Woolverton, C. J. (2010). Prescott, Harley and Klein’s Microbiology. McGraw Hill Publishers, NewYork. 8th edition 1,2 Taylor, D. J., Green, N. O, and Stout, G. W. (1998). Biological Sciences. 3rd edition. Cambridge Publishers, USA. 1,2 Weir, M. D. and Stewart, J. (1997). Immunology. 8th edition. Churchill Publishers. Legend 1- Available in the University Library 2- Available in Departmental/School Libraries 3- Available on the Internet. 4- Available as Personal Collection 5- Available in local bookshops. 3 COURSE OUTLINE Week Topic Remarks 1 Introduction and Course Overview Major topics will be highlighted to the students basic concepts in immunology 2 – 3 Antigens types of antigens classification of antigens sources of antigen determinants of antigenicity 4- 5 Antibodies types of antibodies structures of immunoblobulins classification of immunoglobulins properties of immunoglobulins mechanism of immunoglobulin formation genetic basis of immunoglobulin synthesis 6-8 Antigen/antibody reactions Quchterlony double diffusion technique Radial immunodiffusion diffusion test Demonstration of various techniques used in Radioimmunoassays viral assay to the students Tube precipitin test Agglutination tests Hemagglutination test Immunofluorescence assays Western blot assay Complement fixation test Enzyme linked immunosorbent assay Membrane capture assay Genomic detection assays etc. Mid Semester test 9 -10 Immunity Innate resistance Adaptive immunity the immune system 11 Hypersensitivity Reactions Immediate type hypersensitivity reactions Delayed type hypersentivity reactions 12 Autoimmune diseases 13 Immunodeficiency diseases Primary immunodeficiency diseases 4 Secondary immunodeficiency diseases 14 Introduction to Transplantation Immunology 15 Revision This is the week preceding the final examination. At this time, evaluation. will be done to assess how far the students’ expectations for the course have been met. 5 .
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