Five ENDOCRINOLOGY
Five ENDOCRINOLOGY 101 The doctor who sits at the bedside of a rat Asks real questions, as befits The place, like where did that potassium go, not what Do you think of Willie Mays or the weather? So rat and doctor may converse together. Josephine Miles “The Doctor Who Sits at the Bedside of a Rat” Since the Enlightenment, however, wonder has become a disreputable passion in workaday science, redolent of the popular, the amateurish, and the childish. Scientists now reserve expressions of wonder for their personal memoirs, not their professional publications. Katharine Park and Lorraine Daston Wonders and the Order of Nature Before going on to describe my research and academic career, I wanted to provide the reader with a short “course” in endocrinology, which I still, after all these years, think is wonderful. Let’s face it—the public, the media, and I love hormones. They do such wonderful things. For example, the sex hormones are responsible at puberty for turning on bodily sexual phenotype. A new born baby not secreting thyro- id hormone from its own thyroid will never show normal brain differentiation because crucial connections between neurons in the brain require the presence of this hormone to be completed. The mother’s thyroid hormones take care of the baby’s brain growth while the baby is still in the uterus, but after birth, the baby’s thyroid must secrete its own hormones. Unless treated before six months of age with thyroid hormone, this child will grow up severely dam- aged, what one used to call a “cretin,” with irreversible low intelligence and severe skeletal and muscular growth impairment.
[Show full text]