male germ-line positive a regulation of type antigen processing adult somatic relaxation of stem cell regulation of beak entry into III interferon stabilization of CRD-mediated mRNA and presentation of beak development muscle skeletal muscle population systemic arterial morphogenesis diapause production membrane potential stabilization exogenous peptide monocyte activation development maintenance blood pressure flight forward locomotion antigen via MHC class Regulation of I, TAP-dependent Developmental process biological quality negative Immune system Locomotion sensory organ positive regulation of branched duct hatching secondary neural regulation of precursor cell endoplasmic reticulum oenocyte leading edge cell epithelial cell fate leading edge cell tube formation transmission of process division calcium ion concentration differentiation fate commitment determination, open differentiation nerve impulse hemocyte development regulation of toll-like tracheal system multivesicular body receptor 5 Multicellular organismal process size involved in actin inductive cell endosome transport signaling polymerization-dependent cell motility migration amnioserosa regulation of pathway presynaptic corticotropin regulation of neutrophil angiogenesis formation collateral cellular pH reduction membrane assembly hormone differentiation oenocyte tendon cell involved in proepicardium sprouting of secreting cell development differentiation coronary vascular development injured axon differentiation morphogenesis

post-embryonic zygotic specification endodermal-mesodermal positive regulation basolateral protein localization limb morphogenesis of dorsal/ventral axis cell signaling of photoreceptor cell glucose 1-phosphate UDP-glucuronate positive intermediate hermaphrodite metabolic process metabolic process nurse cell nucleus labial disc differentiation microtubule-based regulation of Wnt mesoderm genitalia anchoring development Localization peroxisome Signaling signaling pathway development development localization by BMP signaling transmembrane pathway positive regulation of receptor protein histone H2A-K15 nuclear-transcribed mRNA sialic acid transport spermine catabolic process Metabolic process tyrosine phosphatase ubiquitination catabolic process, nonsense-mediated decay signaling pathway

detection of 3’-phosphoadenosine detection of virus response to cobalt ion UDP-glucuronate 5’-phosphosulfate glycerol biosynthetic muscle stretch Catabolism biosynthetic process biosynthetic process process from pyruvate maternal ribonucleoside negative regulation protein deubiquitination aggressive vulval location Cellular involved in ubiquitin-dependent triphosphate of histone H3-K36 behavior cell cycle phase Response to stimulus protein catabolic process catabolic process methylation biosythetic Reproductive regulation of cellular process response to response to corticosterone regulation of prostaglandin response to drug nuclear matrix zonula adherens process selenium ion biosynthetic process organization maintenance fusome organization dosage compensation negative regulation positive regulation of B by hypoactivation of transposition, cell apoptotic process of X chromosome RNA-mediated Cellular component constitutive protein negative ectodomain proteolysis reorganization negative regulation regulation of regulation of macrophage of ligase activity phospholipase establishment of regulation of Rap Regulation of biological process proteinase colony-stimulating actin filament telomere C activity proximal/distal protein signal cell polarity cellular response to activated factor signaling reorganization maintenance via caloric restriction transduction positive regulation of negative regulation of positive regulation of Negative receptor activity pathway involved in semi-conservative neurotransmitter protein geranylgeranylation cholesterol efflux glutamate secretion cell cycle replication regulation of receptor metabolism catalytic activity b negative regulation basolateral protein response to DNA damage urate transport directional locomotion inductive cell migration of RNA polymerase I response to histone H3-K18 localization regulation of silicon dioxide induced protein regulatory region L-ascorbic acid acetylation ligase activity phosphorylation sequence-specific DNA binding Locomotion Regulation of acetylcholine transport actin-myosin molecular function Response to stimulus acetate ester forward locomotion filament sliding response to transport positive regulation of ligase activity methylmercury protein O-linked netrin-activated fucosylation regulation of signaling Localization integrin activation pathway negative erythrophore differentiation diacylglycerol maternal regulation of transcytosis biosynthetic process aggressive fatty acid Cell oocyte fate detection of sialic acid transport determination Cellular behavior gurken signaling transport differentiation muscle stretch biosynthetic pathway regulation of Cdc42 protein oenocyte differentiation process Reproductive signal transduction process regulation of prostaglandin biosynthetic process sperm ejaculation negative stomatogastric post-embryonic Catabolism negative regulation of involuntary skeletal regulation of nervous system limb transcription of muscle contraction ribonucleoside regulation of nuclear large rRNA post-translational development morphogenesis polyamine U2 snRNA 3’-end triphosphate processing growth rate transcript from RNA protein catabolic process polymerase I promoter Multicellular organismal catabolic process antigen processing and modification presentation of cell cycle phase process exogenous peptide tracheal pit regulation of germ-band antigen via MHC class I Regulation of biological process formation in open R8 cell spacing shortening regulation of tracheal system in compound eye Cellular endosome size component organization dosage induction of compensation by programmed nuclear matrix intercellular bridge gas homeostasis regulation of cell death comma-shaped organization organization hydrogen peroxide hypoactivation blood vessel interleukin-10 contact inhibition body biosynthesis of X chromosome positive regulation of maturation biosynthetic morphogenesis anterior head development process UCE

TB I COL PR1 PNT2

4 9 6

9

0 TAM 9 CNG 1 A V 00

0

0 100 1 BAR C 93 98 100 100 IV

VRN 8 9 100 POL 1 III 0 0 HON

SAL B BOA PED VI SEV II F1

0.04

LOY REVIGO Gene Ontology treemap

chromosome organization dosage compensation complex assembly CRD−mediated mRNA stabilization dosage compensation involved in dosage compensation by hyperactivation of X chromosome

chromosome organization single−organism process

mitotic sister biological_process organelle chromatid organization segregation positive regulation protein−DNA protein−DNA complex of macromolecule regulation of metabolic process complex assembly subunit organization metabolic process

establishment of regulation of cortical protein negative regulation of mitochondrion cellular process transcription regulation biological quality anchoring cholesterol efflux localization negative regulation of cellular catabolic process response to Ral protein low−density single−organism cellular process signal lipoprotein modulation by positive regulation transduction positive regulation of particle symbiont of host of killing of cells cholesterol storage multicellular apoptotic process of other organism cellular component DNA organismal regulation of cellular organization or metabolism process response to low−density biogenesis metabolic process multicellular organism development multicellular lipoprotein particle regulation of negative regulation regulation of exocyst response to cellular organism development RNA stability of metabolic process localization lipoprotein response

regulation of particle to heat odontogenesis mitotic biological negative regulation of autophagy regulation of regulation of regulation of nurse cell nucleus developmental process anaphase B regulation transcription from RNA catabolic process cellular process anchoring SMAD protein signal polymerase II promoter transduction REVIGO Gene Ontology treemap

ethanolamine kinase activity ATP−dependent RNA helicase activity

kinase activity binding protein binding RNA−dependent ATPase activity RNA helicase activity

choline kinase activity

RNA−dependent ATPase activity

chromatin binding R−SMAD binding GTPase activator activity nucleic acid bindingdouble−stranded RNA bindingdouble−stranded RNA binding REVIGO Gene Ontology treemap

dosage CRD−mediated mRNA kinesin complex compensation stability complex complex intracellular

cell part cell part

cellular_component cytoskeletal part cytoskeleton intracellular organelle

intracellular part complexes

intracellular chromosomal part microtubule plus−end chromosome organelle part

intracellular polytene sex chromosome non−membrane−bounded Noc complex organelle chromosome

cell

Noc1p−Noc2p organelle complexesx complex non−membrane−bounded SREBP−SCAP−Insig organelle part protein complex organelle complex