Journal of Clinical Medicine Article Increased Diagnostic Certainty of Periprosthetic Joint Infections by Combining Microbiological Results with Histopathological Samples Gained via a Minimally Invasive Punching Technique Andreas Enz 1,* , Johanna Becker 1, Philipp Warnke 2, Friedrich Prall 3, Christoph Lutter 1, Wolfram Mittelmeier 1 and Annett Klinder 1 1 Orthopädische Klinik und Poliklinik, Universitätsmedizin Rostock, Doberaner Straße 142, 18057 Rostock, Germany;
[email protected] (J.B.);
[email protected] (C.L.);
[email protected] (W.M.);
[email protected] (A.K.) 2 Institut für Medizinische Mikrobiologie, Virologie und Hygiene, Universitätsmedizin Rostock, Schillingallee 70, 18057 Rostock, Germany;
[email protected] 3 Institut für Pathologie, Universitätsmedizin Rostock, Strempelstraße 14, 18057 Rostock, Germany;
[email protected] * Correspondence:
[email protected]; Tel.: +49-381-494-9315 Received: 2 September 2020; Accepted: 15 October 2020; Published: 20 October 2020 Abstract: Background: The diagnosis of low-grade infections of endoprostheses is challenging. There are still no unified guidelines for standardised diagnostic approaches, recommendations are categorised into major and minor criteria. Additional histopathological samples might sustain the diagnosis. However, ambulatory preoperative biopsy collection is not widespread. Method: 102 patients with hip or knee endoprosthesis and suspected periprosthetic joint infection (PJI) were examined by arthrocentesis with microbiological sample and histopathological punch biopsy. The data were retrospectively analysed for diagnosis concordance. Results: Preoperative microbiology compared to intraoperative results was positive in 51.9% (sensitivity 51.9%, specificity 97.3%). In comparison of preoperative biopsy to intraoperative diagnostic results 51.9% cases were positive (sensitivity 51.9%, specificity 100.0%).