Supplementary Figure 2. Comparison of Deduced Amino Acid Sequences of the VP7 Antigenic

Supplementary Figure 2. Comparison of deduced amino acid sequences of the VP7 antigenic sites (A-D and F) [1] of rotavirus G11 with different G genotypes from the global collection available in the GenBank database. Recent G genotypes present in rotavirus vaccines were also examined. The Korean G11 study strain is boxed and in boldface type.

Strains Region D Region A Region B Region C Region F 65 76 87 101 142 152 208 221 235 245 ....|....|...... |....|....| ....|....|. ....|....|.... |....|....| RVA/Pig-tc/MEX/YM/1983/G11P9[7] TPYMNSTMSETF HEAATQIADDKWKDT MKYDGNSQLDM LTTDPTTFEEVASA HKLDVTTATCT Global G11 RVA/Pig-tc/VEN/A253/1988/G11P9[7] ...... T.... R...... T ...... RVA/Human-wt/BGD/Dhaka6/2001/G11P[25] ...... N...... S...... I...... RVA/Human-wt/BGD/Matlab36/2002/G11P[8] ...... N...... S...... I...... RVA/Human-wt/NPL/KTM368/2004/G11P[25] ...... N...... S...... RVA/Human-X/NPL/04N368/2004/G11P[25] ...... N...... S...... RVA/Human-wt/ECU/EC2184/2005/G11P[6] ...T...... G...... E...... RVA/Human-wt/KOR/CUK1/2005/G11P[4] ...... N...... S...... RVA/Human-wt/KOR/CAU-1/2008/G11P[X] ...... N...... S...... RVA/Pig-wt/KOR/JJ37-pp1/2010/G11P[7] ...A...V.... N..S...... R...... N.A...... F...... RVA/Human-wt/KOR/CAU12-2/2012/G11P[25] ...... N...... S...... T... RVA/Human-X/KOR/GJ0703034/XXXX/G11P[25] ...... N...... S...... Recent G genotypes RVA/Human-tc/USA/Wa/1974/G1P1A[8] AV.T...QE.V. T..S...N.GD...S ....QSLE... Q..NVDS..MI.EN ..INL..T... RVA/Human-tc/USA/DS-1/1976/G2P1B[4] AV.T...SG.P. A..KNE.S..E.EN. .R..NT.E..A K...VN...I...S ..INISIN... RVA/Human-tc/JPN/AU-1/1982/G3P3[9] ..T...RE.V.. T....E.N.NS...... ATL...... TN...... T. ...N...N... RVA/Human-tc/GBR/ST3/1975/G4P2A[6] .A.A...QDNN. S..P...S.TE.... IRFVFGEE..I Q..NTA...T..DS ...NI.ST... RVA/Pig-tc/USA/OSU/1977/G5P9[7] ...... T.... N....E...T..TE...... L.... S...INS..T..N...... S... RVA/Cow-tc/FRA/RF/1982/G6P[1] .A.AD..Q..P. V..SNE...TE...... STQE... .I.N.D...T..TT ...N...... RVA/Turkey-tc/IRL/Ty-3/1979/G7P[17] VVLA.S.QDQIG KA.D.E...PE..A. AH.TNDVA..I Q..NTD...ILTMS ..VNY.V...K RVA/Human-tc/IND/69M/1980/G8P4[10] .N.Q.VSNP.P. V..E.E...SS...... NA..E...... T...... T. Y.IN...T... RVA/Human-tc/USA/WI61/1983/G9P1A[8] .A.A..SQLD.. A..S...G.TE...... STLE... T..NTA...... AS ...... T... RVA/Human-tc/GBR/A64/1987/G10P11[14] .A.A...QDNN. S..P...S.TE.... IRFVSGEE..I Q..NTA...T..DS ...NI.ST... RVA/Human-tc/PHL/L26/1987/G12P[4] .A.V...QQ.S. NSVT.E.T.PD.TH. VQ.QNSLA..V T...VA...... N. ..INI.LN... RVA/Horse-tc/GBR/L338/1991/G13P[18] .A.A...QE.N. N.VVSELN..S..N. V..STEL...I ....TE...... L ..INL...... RVA/Horse-tc/ARG/E403/2006/G14P[12] .A.V...QENI. T...... D.SS...... EAL...... NVA...... TS ..IN...T... RVA/Cow-tc/ARG/B383/1998/G15P[11] NA.A.V.DDKP. TI.SSDLN.PD..N. ...ES.LEM.. V...TNS..T..VN ...... N.... RVA/Mouse-tc/USA/ETD_822/XXXX/G16P[16] .A.A...QP.P. K....E.K.NS...... ASL.M...... V.....I.T. ...N...... RVA/Turkey-tc/IRL/Ty-1/1979/G17P[17] VAVP.K.DDQIG K.....MN.AE..S. A...Q.ET... K...VS....LTTT ..ANY.IS... RVA/Pigeon-tc/JPN/PO-13/1983/G18P[17] VAVP.K.DDQIG N..E.E.N.NE.... V...Q.AG... Q...VA...QLTAT ..VNY.I.... RVA/Chicken-tc/DEU/02V0002G3/2003/G19P[30] ITVQ.Q.AEPIG A..S.E...TE..QP I.....QG..I K...VS...QLTT. ..I.Y.VT... RVA/Human-wt/ECU/Ecu534/2006/G20P[28] .TLA..S.EN.. T..R.E.N.NS.T...... A.L.... Q...VS...... N...... RVA/Cow-wt/JPN/AzuK-1/2006/G21P[29] AA.S...EENI. N.VIS..N...... ADSES... V...VN....L.TT Y.INI..QK.. RVA/Turkey-tc/DEU/03V0002E10/2003/G22P[35] VT.Q.Q.SEPIG T...NE...SE..Q. V.....QG..I K...L....QLTAS ..I.Y.VT... RVA/Pheasant-wt/HUN/Phea14246/2008/G23P[?] VTVL...QTQIG K..SDE.K.SE..N. KYT.S.VA..I Q..NVN...Q.TAS ..I.Y.SN... RVA/Cow-tc/JPN/Dai-10/2007/G24P[33] YINT.T.IEKP. NDVL.E.Q...... R.YE.MT... T...VN...VL.NT Y.INIS.QS.. RVA/Bat-wc/KEN/KE4852/07/2007/G25P[6] .A.A..SQQ.IQ T..K...S....T...... QAQE... I..QTS...... AQ ...... RVA/Pig-wt/JPN/TJ4-1/2010/G26P[?] ...A...RE... V..KNE.N.GS.T.. ...QSDL...... NTD....I.TN ..ININ..... RVA/SugarGlider-wt/JPN/SG33/2010/G27P[X] .V.A...QQ... T..Q.E.N.NS...... STL...... TA...... T. ...N...... G genotypes in current human rotavirus vaccines RVA/Vaccine/USA/Rotarix-A41CB052A/1988/G1P1A[8] .V.A...QEGI. T..S...N.GE...S ....Q.LE... Q..NVDS..M..EN ..INL..T... RVA/Vaccine/USA/RotaTeq-WI79-9/1992/G1P7[5] AV.T...QE.V. T..S...N.GD...... QSLE... Q..NVDS..MI.EN ..INL..T... RVA/Vaccine/USA/RotaTeq-SC2-9/1992/G2P7[5] AV.T...SG... A..KNE.S..E.EN. .R..NT.E..A K...VS...I...S ..INISIS... RVA/Vaccine/USA/RotaTeq-WI78-8/1992/G3P7[5] .S.T...RE.V. T....E.N.NS...... ATL...... AN...... T. ...K...D... RVA/Vaccine/USA/RotaTeq-BrB-9/1996/G4P7[5] .A.A...QDNN. S..P...S.TE.... IRFASGEE..V Q...TA...T..DS ...... ST...

1. Laird AR, Gentsch JR, Nakagomi T, Nakagomi O, Glass RI (2003) Characterization of serotype G9 rotavirus strains isolated in the United States and India from 1993 to 2001. J Clin Microbiol 41: 3100-3111