Oral Cholera Vaccine (OCV)

VACCINE MARKET UPDATE

UNICEF Vaccine Industry Consultation

September 2019 UNICEF Supply Division © UNICEF/UNI199159/Panday Oral Cholera Vaccine Market Update

UNICEF procures Oral Cholera Vaccine for 2 programmatic uses - Preventive immunization campaigns - Outbreak response

Countries receive support for Supply and Operational Cost from Gavi

Countries’ applications for support is approved by two partner groups - Global Task Force for Cholera Control – Preventive Campaign - International Coordinating Group – Outbreak Response Oral Cholera Vaccine Market Update

Suppliers have offered increased availability since 2016

2 out of 3 suppliers of WHO pre-qualified OCV are supplying to UNICEF market

UNICEF projects that offered availability will stabilize in coming years

The available vaccines are kept at suppliers until deployed for Preventive Campaigns or Outbreak Response

The Emergency Stockpile requirement is for 3 million doses at all times Oral Cholera Vaccine Market Update

Increased availability has enabled

- greater share of demand being satisfied - larger and more country requests being satisfied - increase supply to preventive campaigns

Forecasting demand is challenging - reluctance to acknowledge the presence of the disease - competing health priorities - outbreak response demand is inherently difficult to forecast - planning of preventive campaigns in an environment where doses may be required for outbreak response Oral Cholera Vaccine Market Update

Supplied quantity for 2019 to-date is at level with total 2018 quantity

Very dynamic demand market - Outbreak requests materialize with short notice - Preventive campaigns are planned with little time to prepare Oral Cholera Vaccine Market Update

The Gavi Vaccine Investment Strategy included the Oral Cholera Vaccine. Country support for OCV is approved starting 2021 pending confirmation of availability of funding (GAVI replenishment).

Gavi Secr. is designing the application and approval processes to enable support for countries’ preventive immunization activities.

The ICG will retain the authority to allocate OCV for Outbreak Response.

Application Approval Supply Gavi Country Supplier Oral Cholera Vaccine Market Update

Next Steps:

Collaborate with countries and partners to enhance predictability of demand for preventive campaigns Collaborate with partners to manage transition of approval authority to Gavi Secr. Finalise extension of LTAs to bridge supply until Gavi Secr. assumes approval authority – to be discussed with suppliers Tender issuance projected for Q2 2021 for supply start 2022 THANK THANK YOU