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London's Swine Flu Pandemic
Central and North West London NHS Foundation Trust Executive Office Tel: 020 3214 5760 Fax: 020 3214 5761 4 February 2010 Sarah Hurcombe Assistant Scrutiny Manager Post Point 10 City Hall The Queen's Walk London SE1 2AA Dear Ms Hurcombe, I am responding to your request for feedback in relation to London's response to Swine Flu. !asked my Director of Nursing Practice, who is our Infection Control lead, to consider the questions you asked and he has provided me with the following comments: 1. Communication was a bit of an issue at first but this improved rapidly in time. I generally found that staff at NHS London were doing their best to advise where they could. Teleconferencing was a big help and saved a lot of travel time. One final point is that there wasn't any panic at any time when it was declared to be a pandemic. 2. At some of the meetings members of NHS London could become rather defensive to constructive comments. They appeared to take these as personal attacks. A more open debate on the challenges we were all facing would have been helpful. I hope that the above comments are useful. We look forward to viewing others views and feedback when published on your web-site. Yours sincerely, Claire Murdoch Chief Executive Trust Headquarters, Greater London House, Hampstead Road, London NWl 7QY Tel: 020 3214 5700 Fax: 020 3214 5701 www.cnwi.nhs.uk Dear Sarah, Further to the letter from James Cleverly, Chair of Health and Public Services Committee, and in answer to the questions posed: The Ealing Hospital NHS Trust has yet to complete its local debrief, but in general we believe we responded well to the challenge. -
Unsolved Mysteries
© 1993 Nature Publishing Group http://www.nature.com/naturebiotechnology /COMMENTARY• Unsolved Mysteries BERNARD DIXON he hand of the Lord was against fever nine years earlier, and show that most of those the city with a very great destruc patients had also developed rising levels of antibodies tion: and he smote the men of the against Legionella pneumophila. city, both small and great, and But what are the prospects of applying PCR to the ' they had emerods in their secret study of pathogens from previous centuries? As with parts" (1 Samuel 5:9). animal cells, the question hinges largely on finding What on earth was going on microbial DNA that has not been denatured and which here? An outbreak of hemor therefore still contains meaningful coding sequences. rhoids? Venereal disease? Bibli It's a fanciful idea at first, but on reflection the cal citations are not exactly thick on the ground at possibility of retrieving such material seems more scientific meetings, but these were the quotes with plausible than might be imagined. which veteran microbiologist Chris Collins opened Viruses can be maintained indefinitely, like chemi part of the Society for Applied Bacteriology's Sum cals, on a laboratory shelf. There seems every reason mer Conference in Nottingham last month. Theses to suppose, therefore, that some viruses of past times sion ranged over several "old plagues," including may have persisted in, for example, permafrost or several of disputed identity. It also prompted sugges desiccated burial vaults. The prospect of viable organ tions that the polymerase chain reaction (PCR), now isms being released from such sites was taken very widely famed for the fact and fantasy of amplifying seriously by the World Health Organization during human and other DNA from ancient bones, might also the smallpox eradication campaign of the 1970s, be used to retrieve microbial DNA and thus learn when Peter Razzell of Bedford College, London, something about infections in the mists of history. -
Secret Assassins
.. “BIRD FLU” HOAX EXPOSED A. True Ott, PhD –4/5/06 Exactly 30 years ago, in 1976, National Headlines Proclaimed: “Swine Flu Pandemic Poised to Exceed 1918 Death Toll”. The national news media swept America away in an unprecedented fear-based, propaganda campaign to promote what is now recognized as a tremendous money-making hoax designed to enrich large pharmaceutical houses by selling billions of dollars worth of “Swine Flu Vaccinations” to an ignorant public. What stopped the massive scam? Three factors – 1. A few honest congressmen blew the whistle on the conspirators, 2. A few honest microbiologists and medical doctors also went public with the TRUTH, and 3. a precedent-setting series of lawsuits against Rockefeller’s “Big Five” pharmaceutical/vaccine manufacturing houses were victorious; many recipients of the “vaccine”experienced permanent paralysis and even death –all of this caused by the FDA approved and so-called “Safe, Well Tested Vaccine.” Today, alarmingly, THE EXACT SAME SCRIPT PLAYED IN 1976 is once again unfolding on the World Stage. Many of the “players” are the same. The goals of the conspirators are somewhat different however. Money does NOT appear to be the key issue today –POWER, MANIPULATION AND FASCIST CONTROL OF THE AMERICAN PEOPLE are apparently today the key issues. The Horror Story does not need to be re-written. All one has to do is read and internalize the work honest scientists published in 1976, and the history of the 1918 pandemic. The TRUTH still is TRUTH today, 30 years later. I would personally submit, the stakes are infinitely greater, however. -
The Cambridge Historical Dictionary of Disease
P1: FCH/SPH P2: FCH/SPH QC: FCH/SPH T1: FCH CB518-FM CB518-Kiple-V1.cls March 4, 2003 15:23 THE CAMBRIDGE HISTORICAL DICTIONARY OF DISEASE Edited by KENNETHKENNETH F.F. KIPLEKIPLE Bowling Green State University iii P1: FCH/SPH P2: FCH/SPH QC: FCH/SPH T1: FCH CB518-FM CB518-Kiple-V1.cls March 4, 2003 15:23 PUBLISHED BY THE PRESS SYNDICATE OF THE UNIVERSITY OF CAMBRIDGE The Pitt Building, Trumpington Street, Cambridge, United Kingdom CAMBRIDGE UNIVERSITY PRESS The Edinburgh Building, Cambridge CB2 2RU, UK 40 West 20th Street, New York, NY 10011-4211, USA 477 Williamstown Road, Port Melbourne, VIC 3207, Australia Ruiz de Alarcon´ 13, 28014 Madrid, Spain Dock House, The Waterfront, Cape Town 8001, South Africa http://www.cambridge.org C Cambridge University Press 2003 This book is in copyright. Subject to statutory exception and to the provisions of relevant collective licensing agreements, no reproduction of any part may take place without the written permission of Cambridge University Press. First published 2003 Printed in the United States of America Typefaces Poppl-Pontifex 8.75/12 pt. and Poppl-Laudatio System LATEX2ε [TB] A catalog record for this book is available from the British Library. Library of Congress Cataloging in Publication Data The Cambridge historical dictionary of disease / edited by Kenneth F. Kiple. p. cm. Includes bibliographical references and index. ISBN 0-521-80834-0 – ISBN 0-521-53026-1 (pbk.) 1. Diseases – History – Dictionaries. I. Kiple, Kenneth F., 1939– RC41 .C365 2003 616 .009 – dc21 2002031368 ISBN 0 521 80834 0 hardback ISBN 0 521 53026 1 paperback iv P1: FCH/SPH P2: FCH/SPH QC: FCH/SPH T1: FCH CB518-FM CB518-Kiple-V1.cls March 4, 2003 15:23 Contents Preface I xiii 15 Beriberi I 44 Melinda S. -
Were the English Sweating Sickness and the Picardy Sweat Caused by Hantaviruses?
Viruses 2014, 6, 151-171; doi:10.3390/v6010151 OPEN ACCESS viruses ISSN 1999-4915 www.mdpi.com/journal/viruses Review Were the English Sweating Sickness and the Picardy Sweat Caused by Hantaviruses? Paul Heyman 1,2,*, Leopold Simons 1,2 and Christel Cochez 1,2 1 Research Laboratory for Vector-Borne Diseases, Queen Astrid Military Hospital, Brussels B-1120, Belgium; E-Mails: [email protected] (L.S.); [email protected] (C.C.) 2 Reference Laboratory for Hantavirus infections, Queen Astrid Military Hospital, Brussels B-1120, Belgium * Author to whom correspondence should be addressed; E-Mail: [email protected]; Tel.: +32-2-264-4044. Received: 12 October 2013; in revised form: 4 December 2013 / Accepted: 9 December 2013 / Published: 7 January 2014 Abstract: The English sweating sickness caused five devastating epidemics between 1485 and 1551, England was hit hardest, but on one occasion also mainland Europe, with mortality rates between 30% and 50%. The Picardy sweat emerged about 150 years after the English sweat disappeared, in 1718, in France. It caused 196 localized outbreaks and apparently in its turn disappeared in 1861. Both diseases have been the subject of numerous attempts to define their origin, but so far all efforts were in vain. Although both diseases occurred in different time frames and were geographically not overlapping, a common denominator could be what we know today as hantavirus infections. This review aims to shed light on the characteristics of both diseases from contemporary as well as current knowledge and suggests hantavirus infection as the most likely cause for the English sweating sickness as well as for the Picardy sweat. -
Infection Control Through the Ages
American Journal of Infection Control 40 (2012) 35-42 Contents lists available at ScienceDirect American Journal of Infection Control American Journal of Infection Control journal homepage: www.ajicjournal.org Major article Infection control through the ages Philip W. Smith MD a,*, Kristin Watkins MBA b, Angela Hewlett MD a a Division of Infectious Diseases, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE b Center for Preparedness Education, College of Public Health, University of Nebraska Medical Center, Omaha, NE Key Words: To appreciate the current advances in the field of health care epidemiology, it is important to understand History the history of hospital infection control. Available historical sources were reviewed for 4 different Hospitals historical time periods: medieval, early modern, progressive, and posteWorld War II. Hospital settings Nosocomial for the time periods are described, with particular emphasis on the conditions related to hospital infections. Copyright Ó 2012 by the Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved. Approximately 1.7 million health careeassociated infections One of the few public health measures was the collection of (HAIs) occur in the United States each year.1 Hospital infection bodies of plague victims. The bodies were left in the street to be control programs are nearly universal in developed nations and have picked up by carts and placed in mass graves outside of town.3,4 significantly lowered the risk of acquiring a HAI since their inception Other infection control measures included hanging people who in the mid 20th century. As we debate the preventability of HAIs, as wandered in from an epidemic region into an uninfected area, well as the ethical and logistic aspects of patient safety, it is impor- shutting up plague victims in their homes, and burning clothing tant to recall the historical context of hospital infection control. -
THESIS for DOCTORAL DEGREE (Ph.D.)
From the Center for Infectious Medicine, Department of Medicine, Huddinge Karolinska Institutet, Stockholm, Sweden HANTAVIRUSES, ESCAPEES FROM THE DEATH ROW – VIRAL MECHANISMS TOWARDS APOPTOSIS RESISTANCE Carles Solà Riera Stockholm 2019 Front cover: “The anti-apoptotic engine of hantaviruses” A graphical representation of the strategies by which hantaviruses hinder the cellular signalling towards apoptosis: downregulation of death receptor 5 from the cell surface, interference with mitochondrial membrane permeabilization, and direct inhibition of caspase-3 activity. All previously published papers were reproduced with permission from the publisher. Published by Karolinska Institutet. Printed by E-print AB 2019 © Carles Solà-Riera, 2019 ISBN 978-91-7831-525-3 Hantaviruses, escapees from the death row – Viral mechanisms towards apoptosis resistance THESIS FOR DOCTORAL DEGREE (Ph.D.) By Carles Solà Riera Public defence: Friday 15th of November, 2019 at 09:30 am Lecture Hall 9Q Månen, Alfred Nobels allé 8, Huddinge Principal Supervisor: Opponent: Associate Professor Jonas Klingström PhD Christina Spiropoulou Karolinska Institutet Centers for Disease Control and Prevention, Department of Medicine, Huddinge Atlanta, Georgia, USA Center for Infectious Medicine Viral Special Pathogens Branch, NCEZID, DHCPP Co-supervisor(s): Examination Board: Professor Hans-Gustaf Ljunggren Associate Professor Lisa Westerberg Karolinska Institutet Karolinska Institutet Department of Medicine, Huddinge Department of Microbiology, Tumor and Cell Center for Infectious -
Trends in Microbiology
Trends in Microbiology Microbial Genomics of Ancient Plagues and Outbreaks --Manuscript Draft-- Manuscript Number: TIMI-D-16-00114R1 Article Type: Review Corresponding Author: Cheryl P Andam, Ph.D Harvard T. H. Chan School of Public Health Boston, MA UNITED STATES First Author: Cheryl P Andam, Ph.D Order of Authors: Cheryl P Andam, Ph.D Colin J Worby, Ph.D. Qiuzhi Chang Michael G Campana, Ph.D. Abstract: The recent use of next generation sequencing methods to investigate historical disease outbreaks has provided us with an unprecedented ability to address important and long-standing questions in epidemiology, pathogen evolution and human history. In this review, we present major findings that illustrate how microbial genomics has provided new insights into the nature and etiology of infectious diseases of historical importance, such as plague, tuberculosis, and leprosy. Sequenced isolates collected from archaeological remains also provide evidence for the timing of historical evolutionary events as well as geographic spread of these pathogens. Elucidating the genomic basis of virulence in historical diseases can provide relevant information on how we can effectively understand the emergence and re-emergence of infectious diseases today and in the future. © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation Trends Box 1 Trends 2 3 ñ Important challenges to ancient genomic analyses include limited DNA sampling and 4 methodological issues (DNA authentication, recovery, isolation, enrichment, 5 sequencing, false positives). 6 ñ Genome sequencing of pathogens from historically notable disease outbreaks 7 provides insight into the nature of long-term co-evolution of humans and pathogens. -
The English Sweating Sickness, 1485-1551: a Viral Pulmonary Disease?
Medical History, 1998, 42: 96-98 Comment The English Sweating Sickness, 1485-1551: A Viral Pulmonary Disease? MARK TAVINER, GUY THWAITES, VANYA GANT* A recent article in this journal describes an analysis of the 1551 outbreak of the sweating sickness.1 Dr Dyer's research, based on 680 extant parish registers, represents to date the most comprehensive and detailed analysis of the demographic impact of any of the five outbreaks of the sweating sickness of 1485, 1508, 1517, 1528 and 1551. Furthermore, his article supersedes previous analyses of the demographic impact of the sweating sickness based on either parish registers2 or testamentary evidence.3 Contemporary impressions of strong age, class, and sex predispositions of the victims of the sweating sickness to young, rich males are modified to give a more dispassionate and informed picture. He also shows how the sweating sickness was predominantly a rural rather than an urban disease, with a limited overall demographic impact, and that there may have been occurrences outside the five "classic" epidemic years.4 This extensive demographic material is then used to provide a fuller epidemiological explanation for the aetiology of the sweating sickness. The underlying hypothesis is that the causative agent of the sweating sickness was spread by human-to-human contact as well as initially through a zoonosis or an environmental vector. This suggestion of human- to-human transmission stems from two aspects of the register data: first, the observable sequences of gender biases and intra-familial trends of mortalities at a parish level, and secondly from the spread of the epidemic at a national level. -
EMERGING BIOLOGICAL THREATS This Page Intentionally Left Blank EMERGING BIOLOGICAL THREATS
EMERGING BIOLOGICAL THREATS This page intentionally left blank EMERGING BIOLOGICAL THREATS A Reference Guide JOAN R. CALLAHAN GREENWOOD PRESS An Imprint of ABC-CLIO, LLC Copyright 2010 by Joan R. Callahan All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, except for the inclusion of brief quotations in a review, without prior permission in writing from the publisher. Library of Congress Cataloging-in-Publication Data Callahan, Joan R. Emerging biological threats : a reference guide / Joan R. Callahan. p. ; cm. Includes bibliographical references and index. ISBN 978-0-313-37209-4 (alk. paper) 1. Emerging infectious diseases. 2. Health risk assessment. 3. Food security. I. Title. [DNLM: 1. Disease Outbreaks—prevention & control. 2. Food Contamination—prevention & control. 3. Hazardous Substances—adverse effects. 4. Public Health—history. WA 105 C156e 2010] RA643.C263 2010 362.196'9—dc22 2009046252 14 13 12 11 10 12345 This book is also available on the World Wide Web as an eBook. Visit www.abc-clio.com for details. ISBN: 978-0-313-37209-4 EISBN: 978-0-313-37210-0 ABC-CLIO, LLC 130 Cremona Drive, P.O. Box 1911 Santa Barbara, California 93116-1911 This book is printed on acid-free paper Manufactured in the United States of America Dedicated to my great-grandfather MICHAEL FOLEY (1849–1897) Born during the Irish Famine Died from an experimental tuberculosis treatment This page intentionally left blank Contents Preface xi 1. Introduction 1 Public Health: A Short History 2 Koch and His Postulates 2 Hazard, Threat, and Risk 2 Outbreaks, Epidemics, and Pandemics 6 What Is Popular Culture? 6 More Definitions 6 So How Bad Is It? 6 2. -
English Sweating Sickness and the 1529 Continental Outbreak”
Phi Alpha Theta Pacific Northwest Conference, 8–10 April 2021 Anika Esther Martin, Eastern Washington University, undergraduate student, “The ‘English Bath’: English Sweating Sickness and the 1529 Continental Outbreak” Abstract: Sudor Anglicus, or "English Sweating Sickness," was a peculiar disease which afflicted England during the Tudor period. First appearing in the late summer of 1485, Sweating Sickness quickly proved itself to be a terrifying killer. Those who contracted the Sweat were struck ill suddenly, often died within the first twenty-four hours, and suffered from a host of symptoms, the most visible of which being a raging fever and oppressive sweat. Between 1485 and 1551, five major outbreaks of the disease wracked the country, attracting the worried attention of those beyond England. In 1529, those anxieties were realized when a German ship unknowingly carried twelve sick passengers into the city of Hamburg, Germany, introducing the Sweat to Europe. This paper centers on the 1529 continental outbreak of English Sweating Sickness, tracking its path across Europe and exploring the different ways in which mainland Europeans reacted to the disease. Did they follow English precedents in handling the Sweat; or did they develop new policies and remedies? In approaching these questions, I will pay special attention to the German public health system, including a discussion of their city quarantines and medical pamphlets. The “English Bath:” English Sweating Sickness and the 1529 Continental Outbreak Anika Esther Martin Eastern Washington University Undergraduate [email protected] Abstract: 1 Sudor Anglicus, or "English Sweating Sickness," was a peculiar disease which afflicted England during the Tudor period. -
(SARS-Cov-2, 2019-Coronavirus). J Mycol Mycological Sci 2020, 3(1): 000123
Open Access Journal of Mycology & Mycological Sciences ISSN: 2689-7822 MEDWIN PUBLISHERS Committed to Create Value for Researchers The Historical/Evolutionary Cause and Possible Treatment of Pandemic COVID-19 (SARS-CoV-2, 2019-Coronavirus) Niknamian S* Associate Professor of Medicine, John D Dingell VA Medical Center and Wayne State University, Review Article USA Volume 3 Issue 1 Received Date: May 02, 2020 *Corresponding author: Sorush Niknamian, Chief, Division of Infectious Diseases, John D Published Date: June 15, 2020 Dingell VA Medical Center, Associate Professor of Medicine, Wayne State University Detroit, MI DOI: 10.23880/oajmms-16000123 USA, Tel: 313-576-3057; Fax: 313-576-1242; Email: [email protected] Abstract Background: A virus is a small infectious agent that replicates only inside the living cells of an organism. Viruses can infect all types of life forms, from animals and plants to microorganisms, including bacteria and archaea. In evolution, viruses are an important means of horizontal gene transfer, which increases genetic diversity in a way virus. Some viruses especially smallpox, throughout history, has killed between 300-500 million people in its 12,000- analogous to sexual reproduction. Influenza (Including (COVID-19), is an infectious disease caused by an influenza year existence. As modern humans increased in numbers, new infectious diseases emerged, including SARS-CoV-2. We have two groups of virus, RNA and DNA viruses. The most brutal viruses are RNA ones like COVID-19 Sars-CoV-2. Introduction: Coronaviruses are a group of viruses that cause diseases in mammals and birds. In humans, coronaviruses cause respiratory tract infections that are typically mild, such as some cases of the common cold and COVID-19.