For information on the events or to make reservations, Calendar please call one of the DRI Foundation offices listed below. DRIfocus South Shore Sweethearts Long Island Pleasures of the Palate Florida is a publication of the Tennis Tournament October 17, 2005 Diabetes Research Institute Foundation. July 9-17, 2005 Guests of this upscale gathering will Summer 2005/Volume 33, Issue 2 The 29th annual tennis tournament, to be held sample rare wines from around the world Editor at Sportime at Atlantic Beach Tennis Club, will feature and enjoy a gourmet meal prepared by renowned Lori Weintraub, APR 16 divisions, including men’s pro/am, women’s Chef Norman Van Aken at his Coral Gables round robin, and mixed doubles. restaurant, NORMAN’S. Contributors Laurie Cummings North Shore Sweethearts Long Island Fall into Fashion Long Island Natasha Norris Tennis Tournament November 10, 2005 Barbara Olack July 24-31, 2005 Featuring a fashion show and extended cocktail Lauren Schreier One of Long Island’s premier events of the reception, the event will be held at the Cradle of Mitra Zehtab, M.D. summer, the 8th annual tournament will be Aviation in Garden City. Modeled by the New held at Shelter Rock Tennis Club. York Jets and their wives, fashions are courtesy Design of Americana, Manhasset. Franz Franc Design Group Inc. Rod Gilbert Golf Tournament Long Island August 8, 2005 Circle of Champions Florida Photography To be held simultaneously at two locations, Charity Brunch Paul Lester Mark Levine Pine Hollow Country Club and Engineers November 6, 2005 Tom Stepp Country Club, this event includes an afternoon Olympian Gary Hall, Jr. will host a Sunday Von Kantor & Associates of golf followed by an awards dinner and brunch to be held at South Beach's world famous Claude Zick silent auction. Joe's Stone Crab. Foundation Staff & Volunteers

Phil Peterson’s Key West Florida Laugh for the Cure California The Diabetes Research Institute Foundation supports the Poker Run November 6, 2005 Diabetes Research Institute at the University of Miami Leonard September 16-18, 2005 A night with comedian Ray Romano M. Miller School of Medicine, whose mission is to develop and Now in its 33rd year, this annual motorcycle and other leading comics will include rapidly apply the most promising research to treat and cure pilgrimage starts in Miami and finishes in dinner and auctions to be held at those now living with diabetes. To obtain additional information Key West for South Florida’s biggest biker The Improv in Los Angeles. or request copies of DRIfocus, please call (800) 321-3437 or party weekend of the year. e-mail [email protected]. DRI Harold Kart Golf Classic Florida Kids Party for a Cure Long Island November 14, 2005 Diabetes Research Institute Foundation September 17, 2005 An afternoon of golf followed by a National Office To be held at the New York Hall of Science, cocktail reception and awards dinner will 3440 Hollywood Boulevard, Suite 100 the event will feature magicians, clowns, take place at Boca West Country Club. Hollywood, FL 33021 dancers, thousands of interactive exhibits, Phone: (954) 964-4040 Fax: (954) 964-7036 and the worlds largest playground. Empire Ball New York December 7, 2005 Northeast Regional Office IMPACT Dinner New York New York’s Real Estate Division will 150 East 58th Street, 16th Floor New York, NY 10155 September 2005 gather at the Grand Hyatt Hotel for Phone: (212) 888-2217 Fax: (212) 888-2219 To be held at ABC Carpet, the young this elegant affair. professionals of IMPACT will gather for Long Island Regional Office Love and Hope Preview Party Florida a cocktail reception that includes dancing, 45 Glen Cove Road sweepstakes and a silent auction. December 8, 2005 Greenvale, NY 11548 This dinner reception, to be held at the Phone: (516) 621-8804 Fax: (516) 621-8501 Diplomat Country Club in Hallandale, is the official start of the Love and Hope season.

Non-Profit DRIfocus US Postage Diabetes Research Institute PAID National Foundation Office Diabetes Research 3440 Hollywood Blvd. Institute Foundation Suite 100 Hollywood, FL 33021 www.diabetesresearch.org address service requested Diabetes Research Institute Foundation Summer 2005 / Volume 33, Issue 2 www.diabetesresearch.org

DRIMiami • Newf Yorkocus • Long Island • California • Washington, D.C.

NFL Greats DRI Scientists Demonstrate New Approach to Transform (Article on page 13) Stem Cells Into Insulin-Producing Cells

Combining their respective expertise, molecular biologists and stem cell experts from the DRI reported the first successful use of protein transduction domains (PTD) to promote pancreatic cell differentiation. The technology uses small membrane-crossing proteins to facilitate the penetration of much larger “piggy-backed” molecules that would otherwise not be able to enter targeted cells. Using these PTDs, DRI scientists demonstrated that a critical developmental factor involved in the development of insulin-producing cells, neurogenin 3, can be introduced into pancreatic stem/progenitor cells, successfully promoting their differentiation into endocrine Former Dolphins Quarterbacks Don Strock and Dan Marino at the 22nd annual cell types capable of producing both insulin and glucagon as in the normal pancreas. Don Strock Diabetes Golf Classic. The findings appeared in the March issue of the journal Diabetes, and drew considerable attention from the scientific community. The study, which was done using mouse stem cells, is proof of principle that the approach is indeed successful, and the findings open a promising new Hall Honored avenue of science that could quickly advance stem cell research and enable the development (Article on page 15) of more insulin-producing cells, or islets, for transplant into patients with type 1 diabetes.

(continued on page 8)

ISLET POTENCY WORKSHOP HELPS SCIENTISTS DETERMINE HEALTH, QUALITY OF CELLS Honored at the 14th annual Feast Among the Grapes, DRI Foundation board member and Olympic medalist Gary Hall, Jr., Dedicated to making islet transplantation procedures, as well as novel approaches being together with his wife, Elizabeth. a clinical reality for those with diabetes, the DRI developed at different institutions. We were able to recently hosted a two-day workshop focusing on the determine which methods require enhancement to new methods used to test the quality of islet cells ensure the best preparations for our recipients,” said PGA & NBA prior to infusion into patients. Dr. Luca Inverardi, director of Immunobiology of Islet (Article on page 10) Transplantation at the DRI and one of the organizers Attended by 24 researchers from 12 institutions of the workshop, which was sponsored by the around the world, The Islet Potency Workshop was a National Institutes of Health (NIH) and Clinical forum for investigators to discuss new technologies Islet Transplant Consortium. and develop standardized ways to assess islet viability and safety that can be carried out at all islet centers. Throughout the two days of hands-on presentations, These agreed-upon standards will be necessary for scientists studied various methodologies currently in obtaining Food and Drug Administration (FDA) approval use at different centers and together, judged their of islet transplantation as it continues to move forward effectiveness in determining if an islet preparation as an accepted treatment for type 1 diabetes. meets the quality standards necessary for Senior PGA pro Mark Pfeil with DRIF clinical application. National Board Member Sandy Fox and “It was a great opportunity to meet with fellow NBA star Derek Fisher scientists and look at standard assessment (continued on page 8) A Message from the Chairman

Dear Friends, among them, the ability to test the health and quality presented to these major contributors throughout of donor islets prior to transplantation. The Institute the country, with events held in Florida, New York, This has been an recently hosted the first Islet Potency Workshop and California, or individually presented. Our exceptional year for the (cover story), where investigators learned the cutting- sincere gratitude is extended to all of our Diabetes Research Institute edge procedures necessary for determining islet generous contributors. and Foundation, and we viability. Ultimately, these guidelines will be used for could not have achieved all securing FDA approval of islet transplantation as it Our year was also filled with many other that we have without your help. We have just closed moves toward widespread clinical application. successful events, and you can read more about out year two of an aggressive five-year plan to raise these activities, and the outstanding volunteers $100 million for the DRI’s cure-focused research Stem cell research continues to be a top priority who made them happen, in this issue. programs, and I am pleased to report that we are at the DRI, and the recent breakthrough (cover story), well on the way to accomplishing our goal. which was reported on the NBC Today Show and in My best wishes to you and your family for other national media, is just one example of how a safe and enjoyable summer. Thank you again for The Foundation’s support over the last 12 your contributions are making a real difference for your continued generosity and commitment to months has enabled the Institute to make signifi- those with diabetes. The Institute’s work in this area our mission. cant progress in its ongoing research programs, continues to be funded solely through private Sincerely, move ahead with a number of new initiatives, and philanthropy to ensure that this critical research secure prestigious grants from the National Institutes moves forward. of Health (NIH) and other funding entities. Much of this support came from the numerous As a result, the DRI has continued to play a donors who were honored through our Cycle of Marc S. Goodman leading role in advancing many vital research areas, Discovery recognition program. Awards were recently Foundation Donors Recognized Awards from the DRI Foundation’s Cycle of Discovery series were recently presented to donors who made major gifts during 2004-2005. The award program corresponds with the Foundation’s cumulative giving designations (see page 4).

1. 2. 3. 4. 5.

6. 7. 8. 9. 10.

11. 12. 13. 14. 15.

2 Foundation Donors Recognized (continued)

16. 17. 18. 19. 20.

21. 22. 23. 24. 25.

26. 27. 28. 29. 30.

31. 32. 33. 34. 35.

36. 37. 38. 39. 40.

1) Ed Sullivan, president of the Building and Construction Trades Department, AFL-CIO, with Drew Varga, vice president of Caesars Entertainment, and Nancy Smalkas of Bally’s/Paris and Flamingo Las Vegas, Governors’ Society 2) Harold and Kelly Doran, Distinguished Humanitarians 3) Nurit Gans of Foundation for Diabetes Research, Distinguished Humanitarian 4) Jane and Jerry Goodman and Ruth Schwartz, Distinguished Humanitarians 5) Ramon and Tina Poo, Distinguished Humanitarians 6) Valerie and Dr. Camillo Ricordi, Distinguished Humanitarians 7) Miriam and James Sensale, Distinguished Humanitarians 8) Linda Coll of Carnival Cruise Lines, Grand Founder 9) Dr. Sol and Mitzi Center, Grand Founders 10) William and Joan (not shown) Fishlinger, Grand Founders 11) Micki and Joseph Mele, Grand Founders 12) Brenden Connors of MOSAIC, Grand Founder 13) Samantha Shanken accepts Exploration on behalf of her parents, Hazel and Marvin Shanken, Grand Founders 14) Frank Hurt, president of the Bakery, Confectionary, Tobacco Workers and Grain Millers International Union, Founder 15) Joel Friedman, Founder 16) Barbara and Jonathan Hatz, Founders 17) Arthur Hertz, Founder 18) Dwayne Priest, Household Credit Card Services, Founder 19) On behalf of JAD Corporation, Founder, Joseph Dussich together with Peter DiCapua, chairman of the Empire Ball 20) Gary Koenig, Founder 21) Mark (not shown) and Janet Puntillo, Founders 22) Gene and Iris Rothstein, Founders 23) Sandra Smith, Founder 24) Sandy and Senator Paul Steinberg, Founders 25) Terry Carbaugh of Turner Construction, Founder 26) Laurie and Larry Wells, Founders 27) Oscar Owens, international secretary/treasurer of Amalgamated Transit Union, Benefactor 28) Drs. Carol Nudelman Blumberg and Morton Blumberg, Benefactors 29) Wayne Taub receives Query for CBRE Real Estate, Benefactor, from DRIF Chairman Marc Goodman (left) and Vice Chairman Tom Stern (right.) 30) Merle Delancey, Jr., of Delancey Printing, Benefactor 31) Shelley and Steven Deutsch of Together Against Diabetes, Benefactor 32) Saul and Dalia Glottmann, Benefactor 33) Angelo Dell'Olio of IESI Corporation, Benefactor 34) Tammy and Steven Klein, Benefactors 35) Joel and Ilene (not shown) Joachim, Benefactors 36) Marsha and Arthur Katon, Benefactors 37) Tova Leidesdorf, Benefactor 38) Fran and John Luebs, Benefactors 39) Helene and Martin Myers, Benefactors 40) James C. Halpin of Platinum Maintenance, Benefactor 41) Blanca Rodriguez, Benefactor 42) Michael Landis of Schindler Elevator, Benefactor 43) Ed Sullivan with David Brenner and Bill Rivers of The Segal Company, Inc., Benefactor 44) Morton F. Silver (right), Benefactor, with his son, Thomas Silver. 45) Lenore Toby Simmons, Benefactor 46) Arline and Jack Strick of The Frank Strick Foundation, Benefactor 47) Gene Degan of Stuart Dean Company, Benefactor 48) Jim Doran of Vornado Realty Trust, Benefactor 49) Susan Blash Weiss and Gary Weiss, Benefactors 50) Jerry and Rina Weinbrom, Benefactors 51) Donald and Rhoda White, Benefactors 52) Robert A. Pearlman, DRIF president, presents Query to Marsha, Jessie and Fred Wolinsky, Benefactors 53) Peter DiCapua presents Query to Neil Di Vencenzo of Zwicker Electric, Benefactor

3 Foundation Donors Recognized (continued)

41. 42. 43. 44. 45.

46. 47. 48. 49. 50.

DONOR LEVEL AWARD Benefactors $25,000+ Query Founders $50,000+ Hypothesis Grand Founders $100,000+ Exploration Distinguished Humanitarians $250,000+ Realization Governors’ Society $500,000+ Translation Leadership Council $1,000,000+ Perpetuation Chairman’s Council $5,000,000+ Validation 51. 52. 53. Visionaries $10,000,000+ Innovation

Long-time Supporter Honored with Humanitarian Award

John Jacobs, president of Union Central Life Insurance, grants Juan Elias Calles, CLU, ChFC, the 2005 Lester A. Rosen Humanitarian and Achievement Award as his wife Ivette, and their daughter Ivette Marie look on. The honor was accompanied by a $5,000 check, which Juan, a member of the DRIF Board of Directors for nearly 20 years, immediately bestowed to the DRI. Juan and Ivette became involved with the Institute after their daughter was diagnosed with type 1 diabetes in 1985. Since then, their efforts have ranged from spearheading street corner collections, to hosting educational receptions in their home to introducing scores of people to the work of the DRI. Not only are he and Ivette Grand Founders of the organization, but Juan was instrumental in initiating the Foundation’s planned giving program. He continues to set an example for others to follow, and we are most grateful for his continuing efforts on our behalf.

Law Firm Recognized for Pro Bono Work

DRIF's Sandra Cahn, director of the Northeast Region, presents an award of appreciation to Roy Belden of Chadbourne & Parke, LLP, in recognition of the pro bono work the international law firm has done for the Foundation. Mr. Belden and his firm have been assisting the DRIF in the area of copyright and trademarks for almost fifteen years.

4 All About Andrew

husband, we figured it out. Javier was my rock,” explained Andria, who attested that the real reason said Andria. for the event’s success was because of a hard- working committee and incredible sponsor support. During that time, family and friends flooded the hospital, bringing presents and well wishes for The tournament raised more than $300,000. Andrew. But the young boy with an embracing and While the Holtz Family was the presenting sponsor, infectious personality could not hold on to gifts that Javier and Andria offered special thanks to Title he felt he did not need or deserve. In his innocent Sponsor Building and Construction Trades mind, he wasn’t sick, and Andrew went from one Department of the AFL-CIO, Gold Sponsor Stanford hospital door to the next offering his presents to Financial Group, Silver Sponsor Southern Wine & others on the floor – kids who he felt could use the Spirits of South Florida, and Bronze Sponsors The Holtz family: Matthew, Javier, cheering up much more than he could. Gallagher Financial Systems, Inserra Supermarkets, Karlton Investment Group, Deborah and Scott Nicole, Andrew and Andria. “That day we left the hospital, another mother Robins, Subway/Sager Development, Wachovia told us how lucky we were to be going home,” Securities LLC, and Warren Henry Automobiles. “For me, this was about Andrew,” explained Andria continued. “It was very overwhelming to be Andria Holtz, mother of three, one of whom has there, but we were focused after that.” Next on the “We look forward to hosting this event again type 1 diabetes. She was referring to the DRI Golf Holtz’s agenda was to get involved with the effort next year,” said Andria. and Tennis Classic, which was held on January 31. to find a cure. With her husband Javier, she organized the tourna- Married for 16 years, the Holtzs have two other ment for the DRI Foundation, but in their hearts, Ironically, the couple was already very aware of children, Matthew, 16, and Nicole, 13. Each family it was a personal mission to help find a cure the important work of the DRI. Both were raised in deals with a child’s diabetes diagnosis differently, for their youngest son. South Florida and came from very philanthropic but for the Holtz family, there was only one way – families. Andria’s parents, Diane and Aristotle Ares, as a complete family unit. Three years ago on Andrew’s seventh birthday, and Javier’s parents were involved with the DRI well his parents noticed the signs – lethargy and before Andrew’s diagnosis. Diane and Aristotle have Javier concluded, “While taking a tour of the frequent urination. They ended up at the Holtz been active members of the Love and Hope com- Institute, I realized that DRI scientists are on the Children’s Hospital, which was named in honor of mittee for many years. Fana and Abel are on the verge of finding a cure. One of my other thoughts a landmark gift from Javier’s parents, Fana and Foundation’s honorary board of directors and are was how lucky we are to have the DRI right in our Abel Holtz, and the Fana Holtz Foundation. Grand Founders of the organization. own backyard. Everyone with diabetes can look forward to the day when they will no longer need “We intended that hospital to help others. This Javier, who served as president of Capital insulin. With the right amount of money and wasn’t happening, not to our son,” Andria said of Factors in Boca Raton, a Regions Financial support, we can accomplish this goal.” her initial despair. In fact, the whole family spent Corporation Company, took his support to the next some time in denial, but the daily demands of dia- level by joining the Foundation’s Florida board. Last betes do not allow much time for adjusting. Moving year, he served as tournament chairman for the DRI forward would bring hourly reminders of testing Golf Classic at Trump International Golf Club. This Andrew’s blood sugar and multiple injections year, Andria joined him, and they brought the through the course of one day, cementing firmly tournament closer to their own neighborhood, the into their lives the reality of the disease. La Gorce Country Club on Miami Beach. “I knew that I could administer the shot. “We all worked really hard, and everyone had I knew I could do it, because I didn’t want anyone such a good time. We had an amazing silent The DRI Golf and Tennis Classic Committee worked hard to else touching my son, and together with my auction and a young, fun group of people,” make the event a success. DRI Dream Gift Auction on eBay

Do you have designer handbags, vintage jewelry, or other fabulous items that would be hot sellers on eBay?

Set to launch during the busy holiday gift-buying season, the DRI Dream Auction on eBay.com, the world’s online marketplace, will include an extensive catalog of unique gifts, such as: weekend getaways to the most alluring cities in the U.S., rare wine collections, celebrity encounters, luxurious cruises, and so much more.

We need your help to garner additional gifts. Perhaps there’s something haute couture in your closet that you’re willing to part with, or chances are someone you know or places you frequent would be happy to donate an item for the auction. To make a tax deductible gift donation, contact Steve Fishman at [email protected] or call 866-454-0448.

5 Are you a member of the DRI Heritage Society?

Individuals who ensure the future of the DRI Diabetes Research Institute Foundation Honors through generous provisions made in their estate plans via wills, life insurance, charitable remainder New Heritage Society Members trusts and other planned giving vehicles are recognized as part of the DRI Heritage Society.

Heritage Society members are included on a designated wall of honor at the Institute. A special award is presented to them following written confirmation of their gift. Heritage Society members are invited to attend one of the DRI Foundation’s donor appreciation dinners held annually. They 1. 2. 3. are also listed in the DRI Annual Report as well as the Love and Hope Ad Journal. Ultimately, upon receipt of the gift, the donor’s name will be included on the designated wall within the Diabetes Research Institute reflecting their cumulative giving level.

If you would like to become a DRI Heritage 4. 5. 6. Society member, please contact Jill Shapiro Miller at (800) 321-3437, or complete and return the form 1) Sue and Dr. Norman Kenyon 2) Lillian Redrich 3) Susan and Neil Rosenberg 4) Beatrice and William Sahm on the reply envelope in the center of this newsletter 5) Gale Goldstein Tucker 6) Lori and Lary Weintraub indicating that you would like more information on the DRI Heritage Society. We will be in touch with you.

Gearing Up for Workplace Giving Campaigns

As August rolls around, many corporate and government employees are asked to consider making a gift to the causes that are important to them via workplace campaigns. These gifts can usually be deducted from payroll making it an easy way to provide support to one or more charities of your choice.

The DRI depends on these annual contributions for a significant amount of income each year. If your employer conducts an annual campaign, please look for the DRI under the America’s Charities federation or check the index of your campaign guide. If America’s Charities is not included in your employers’ campaign, you may be able to request a donor option form to write in the charity or charities of your choice. If that is not an option, we would like to work with you to ask your employer to consider adding us in the future.

One of the easiest ways you can assist the DRI in continuing its important work is to become a Workplace Ambassador and encourage your co-workers to contribute via your #0496 workplace campaign. If you would like to learn more about how you can help, contact Kate McGuinness at 1-800-321-3437, or send her an e-mail at [email protected].

6 Letters to an American Champion

Dear Gary, My name is Felipe Lamar. I was diagnosed with diabetes four months ago. I’m seven years old and I watched Seven-year-old Felipe presents a you the whole Olympics and you are my hero… commemorative scrapbook to Gary Hall, Jr.

Only a child could have written words so simply stated that convey such depth of Messages to the three-time meaning. When the DRI Foundation called out to those affected by diabetes for letters Olympian were mounted into a of congratulations for Florida board member Gary Hall Jr., Felipe and several like him commemorative scrapbook and responded. The Foundation received letters, photos and drawings from kids and presented to Hall at the Circle Emilio and Cathleen Lamar with their sons, parents across the country with kudos for Hall on his 2004 Olympic gold medal in of Champions Charity Brunch. Emilio, Felipe and Miguel. the 50-meter freestyle. Below are a few of their sentiments: The intimate gathering of 150 friends and fans was held at South Beach’s Joe’s Stone Crab on December 5. Thanks again for making me believe I can do anything, Felipe was granted the special honor of presenting the scrapbook to Hall. Leading and diabetes won’t stop me. Clare, 11, Manchester, VT up to the event, he practiced his speech over and over, even rehearsing it in front of his class. When the moment came, his nervousness was nearly undetectable as he I was glad to see someone with diabetes just like me. Zyler, 5, Thornton, CO delivered the words with honesty and admiration, eliciting a few tears from some and wild applause from everyone. We hope that we continue to have examples to show [Emily] of people who don’t let obstacles, especially diabetes, get in the way According to Felipe’s mom, Cathleen, their entire family has been deeply touched by the star athlete. Hall’s autographed picture hangs in their kitchen as a symbol of of their dreams. Written by the parents of Emily, 2, Danville, NH strength. In Felipe’s own words, “Lots of people have heroes. I’m so lucky because I actually got to meet mine.” I have diabetes too, type 1 just like you. Ariela, 8, Miami, FL Hall’s Olympic triumphs and personal strengths have filled the Lamars’ hearts with I like your effort and how you never give up, even with your inspiration and hope, allowing them to dream of exciting possibilities for Felipe’s diabetes! Jennifer, 17, Stoneham, ME future. But their greatest hope for their son and for all people with diabetes is a cure. They’ve joined the Diabetes Research Institute Foundation and the legion of individuals You’ve overcome something none of the other swimmers had to do. who are serious, passionate, and committed to finding a cure for this disease. Lizzy, 12, Rockford, IL

Diabetics make the best swimmers! MacKenzie, 15, Englewood, FL

Canyon Ranch Spa Trips Support the DRI

Live well. Stay healthy. Two things we all aspire to Rose’s efforts began four years ago after the do, and a life philosophy that Sondra Rose truly granddaughter of her longtime friend, Naomi Schurr, takes to heart. Though retired, Rose is extremely was diagnosed with type 1 at 11 months. It was active, hiking, playing tennis and golf, exercising Rose’s daughter, Stephanie Rose Goldstein, who indoors and out. She’s a patron of the arts, enjoys a put her up to the challenge of raising significant variety of hobbies, and is involved with multiple funds for a cure. Sondra Rose (left) organizes spa trips to help find a cure for organizations, groups and clubs. the two granddaughters of her longtime friend, Naomi Schurr. “Stephanie said, ‘You’re a teacher. Think of a In her spare time, Rose, otherwise known as creative way to raise money for diabetes research.’ “When we found the DRI, we just felt that they the “Spa Maven,” organizes discounted group trips I had organized a spa trip for another organization are so much more on the cutting edge,” stated to Canyon Ranch, one of the world’s top destination before, so it was something that was very natural to Rose. Last October, Schurr’s other granddaughter spa resorts. In exchange for the low rates, Rose me. I started by asking everyone for a $50 donation, was also diagnosed with diabetes at the age of five, requires a $100 per person minimum donation then $75, now $100. Some people even give more,” and Rose is more determined than ever to see a to the DRI. In one year, she has raised more Rose said delightedly. cure for the two girls during her lifetime. than $25,000. Though at the beginning of her fundraising Rose offers discounted rates at Canyon Ranch’s “I feel like I’m doing a very good deed, and mission, Rose’s contributions were being donated two extraordinary locations in Tucson, AZ, and the there’s such a wonderful health component at to another diabetes organization, she and the Schurr Berkshires of Lenox, MA. To find out more, visit Canyon Ranch even though it feels like a complete family now support the cure-focused research www.diabetesresearch.org or contact Rose indulgence,” said Rose, a former English teacher. at the Institute. directly at [email protected] or (516) 295-0096.

7 (continued from page 1) DRI Scientists Demonstrate New Approach to Transform Stem Cells Into Insulin-Producing Cells

The PTD study uses Neurogenin 3 (ngn3), The DRI team has already begun testing a protein known to ‘prime’ the formation of this approach in human embryonic stem islets during pancreatic development, and cells, and other TAT-fused proteins that are tags it with a small ‘facilitating’ peptide known to be involved in islet development called TAT. This tag carries ngn3 into the are already in the pipeline. stem cells in culture. The resulting protein is “Yesterday we knew what the key genes then purified and added to the culture medium were that make a stem cell turn into an Pdx1, an essential protein that triggers of immature pancreatic cells, where it insulin-producing pancreatic cell; today we pancreatic development, was engineered enhanced their differentiation into islet cell have demonstrated a ‘short cut’ that may to be taken up by cells simply by adding types with both high efficiency and speed. it to the culture medium. DRI scientists work to unravel the complicated signals Juan Dominguez-Bendala, PhD, and Ricardo Scientists at the DRI have been using PTD involved in their activation. We can now turn Pastori, PhD, show that 100% of cells in technology for quite some time to preserve on the genes, and do so in the right order, in a culture take up the protein within and enhance islet cell function. “The order to get functioning cells,” adds Dr. minutes of exposure. TAT/PTD, is perhaps the best characterized Dominguez-Bendala. “This approach lets us “Even though we know which genes are PTD,” adds Ricardo Pastori, PhD, director of easily add and remove proteins as needed activated in normal pancreatic development, Molecular Biology at the DRI and co-investi- from the developmental process, and might and in which order, our understanding of gator in the study, “and it has been proved to therefore have significant advantages over the molecular signals that turn them on is efficiently deliver peptides as well as full-length other less flexible approaches such as gene still very limited,” explains Juan Dominguez- proteins to a wide variety of cells and tissues. therapy.” Bendala, PhD, lead scientist in the study. This novel strategy raises the possibility of The DRI team has already begun “Here we’ve demonstrated that ‘protein therapy’ designing ‘self-carrying’ proteins that can testing this approach in human can be used successfully to accelerate stem sequentially educate human embryonic stem embryonic stem cells. cell differentiation, bypassing the need for cells to fully functioning pancreatic cells, signaling events that we don’t fully perhaps resulting in a limitless supply of islet understand yet.” cells for transplantation. That is our aim.”

ISLET POTENCY WORKSHOP HELPS SCIENTISTS DETERMINE HEALTH, QUALITY OF CELLS

(continued from page 1) A basic test performed pre-transplant evaluates how islets respond to a glucose challenge, which measures if a sufficient amount of insulin is produced on demand. The intricacies of this method often vary from center to center, however, making it difficult to compare results. Such variables as the type of culture media, the sample size, incubation temperature, and even the kits used to measure the insulin response often differ from one institution to DRI's Dr. Luca Inverardi, director of Immunobiology of Islet Transplantation (seated, center), and Scientific Director the next. The group adopted standards for many of Dr. Camillo Ricordi (standing, center), together with the participants in the Islet Potency Workshop. these variables, and agreed to conduct studies to determine others. complexity of the procedure may prohibit some field of islet isolation and transplantation moves One of the more advanced technologies centers from using the new technology. forward, this workshop will be one of the key steps in defining islet parameters to support ongoing examined by the participants was Laser Scanning The safety of the islet preparation remains a Cytometry (LSC), which determines the viability of clinical islet transplant trials,” said Dr. Jonathan critical factor that is routinely tested throughout the Lakey, director of the Clinical Islet Laboratory at the the beta cells within an islet. Dr. Hirohito Ichii, who isolation procedure, as well as prior to transplantation. works in the DRI’s Human Cell Processing laborato- University of Alberta in Edmonton, Canada. “Many Several commercial assays are available today, and of the assays described and taught by Dr. Ricordi ry, demonstrated how this revolutionary technique the centers will continue to conduct studies to identifies beta cell-specific apoptosis (pending cell and his team at the DRI are new, cutting-edge determine which agents are the most reliable assays that will increase the understanding and death) at the most fundamental cell level. The data and effective. generated by LSC is far more useful than that from knowledge of islet quantification and viability that prior methods in determining the quality and health “This was a very important workshop for the are so desperately needed in the field.” of an islet preparation. However, the high cost and groups involved in clinical islet programs. As the

8 Under the Microscope with Alejandro Caicedo, Ph.D.

Together with other DRI scientists, Dr. between the alpha and beta cells, for Caicedo will be conducting studies in example, that are not seen in the rodent animal models to study the effect of key islet being used to study type 1 diabetes. molecules on isolated islets in order to determine the islet’s response to glucose. We’ve also begun work using a novel The goal is to combine the knowledge in vivo model that uses an innovative learned from in vitro laboratory studies immuno-privileged transplant site, which with in vivo animal studies to improve the allows us to study the human islet transplant quality of human islets used in transplan- in a living system without the worry of tation and the clinical outcomes of the rejection. The transplant technique islet transplant program. involved is simple, the islet graft is vascu- larized within a week, and it allows us to Q. What is your focus of research perform critical metabolic studies with at the DRI? easy monitoring of the results.

A. Simply put, my primary objective Q. How will this specifically affect is to find out how human islets work. clinical islet transplantation at the DRI? For the last 20 years or so, most of the metabolic information upon which scien- A. Ultimately, we hope that a clearer tists have based their assumptions comes understanding of the physiology behind from data generated from mouse and rat the human islet will help us identify what islets. We know, for example, that human is a ‘good’ or ‘optimal’ islet preparation Islet transplantation has become a islets are stimulated to release insulin by prior to our using it in a clinical transplant. successful reality for several hundred glucose challenges, but we have little people throughout the world who have data to reflect the cellular mechanics Q. What do you find most difficult received infusions of these insulin- involved in turning this release “on” and in your research? producing cells. But the challenge for “off” at the proper times. We also know the scientists at the DRI to make the human beta cells are influenced by other A. Now that I am part of the faculty, therapy more widely available to patients hormone-producing cells in the islet, but the biggest challenge for me is my with type 1 diabetes continues. One area the specific mechanisms have not been administrative duties; keeping up with of scientific focus that is being actively well documented. That’s my challenge. required paper work can be very daunting, pursued at the Institute aims to improve, but being in charge of projects is new and then ensure the health and function Q. What are the most exciting and very exciting. of the islets prior to transplantation. This findings you have had in your first 6 is the task that a new DRI researcher, months at the DRI? Q. As the “new guy”, what is it like Alejandro Caicedo, Ph.D, has adopted working at the DRI? as his own. A. We’ve made very important findings recently that relate to the structure of A. The DRI is a gold mine for any Dr. Caicedo joined the staff in November human islets, which is significant since it researcher. The resources, both human of 2004 as a Research Assistant Professor likely impacts metabolic function directly. and material, are wonderful. You are not of Surgery in the Cell Biology and Signal We have found that human islets are in an ivory tower like at many research Transduction laboratory, under the direction quite different from rodent islets, which institutes. At the DRI, you can see the of Dr. Per-Olof Berggren. His training is the source of much of our current patients that will benefit from your and previous research involved cellular information. Most textbooks show that work each and every day, and that is physiology and cellular signaling, which rodent islets have a large core of beta so rewarding. focuses on cell-to-cell communication cells surrounded by alpha, delta and pp and the effects of certain hormones and cells mantling that core. In human islets secretions on target cells. This expertise however, the cell types are less compart- provided a perfect foundation for Dr. mentalized and more intermingled, Caicedo’s current research into the intricacies suggesting that there may be different of islet cell signaling and imaging. communication patterns occurring

9 EVENTS California

INCREDIBLE HEROES On Halloween day, John Lasseter, executive producer of The Incredibles, and California board member John Ratzenberger, best known as “Cliff Claven” on Cheers, took on the roles of real heroes to the DRI by making possible a benefit screening of this Disney/Pixar Animation Studios’ film about a family of undercover super- heroes. More than 800 guests, which included families and celebrities, arrived at Walt Disney Studios in Burbank for the special screening, which featured a Halloween parade and costume contest and raised more than $70,000. Board member and Event Co-Chair Paula Wilson (left), dressed as “Cinderella,” paused for a LABOR OF LOVE: 20 YEARS photo with the Foundation’s Barbara Singer, Honorary Committee member Mary Farrell, Honorary Event Chair OF CARING Ratzenberger (second from right), and Honorary Committee member Stu Bloomberg.

This year’s Labor of Love Golf Tournament marked its 20th anniversary. More than 200 SHOOTING FOR SUCCESS AT players from the business and labor communities gathered for the event, which was held at the DRI GOLF CLASSIC world famous Paiute Golf Resort in Las Vegas in February. Following the day’s activities, an Co-Chairs Ken Bernstein and Kiara Walbridge, along awards banquet was held at Bally’s Hotel and with Celebrity Chair Derek Fisher, welcomed 140 Resort, (top photo) where Drew Varga (left), golf aficionados to California’s 2nd annual DRI Golf vice president of Caesars Entertainment, and Classic, held May 23 at El Caballero Country Club in Nancy Smalkas (right) of Bally’s/Paris and Tarzana. Featuring a golf clinic led by Senior PGA Flamingo Las Vegas, presented a check for professional Mark Pfeil and a live auction hosted by $62,000, to Ed Sullivan (center), president of former L.A. Dodger Jay Johnstone, the event raised the Building and Construction Trades over $130,000. A special thanks was extended to Department. Also pictured, (bottom photo): Platinum Sponsors Wells Fargo Foothill, represented one of the winning foursomes, Ray Sesma, by Pete Schwab (pictured left with Ken Bernstein), trustee of the Painters and Allied Trades and Turner Construction Company, as well as Gold Labor-Management Cooperation Initiative; Sponsors: Leonard Bernstein and Stephen Marks, James P. Hoffa, president of the International City National Bank, Dave DiTomaso and Subway of Brotherhood of Teamsters; John Gage, president Ventura County, Hamilton Brewart Insurance, of the American Federation of Government Navigant Consulting, Roberta and Steve Small, Employees; and Jimmy Williams, president of and the Werdesheim Family. the International Union of Painters and Allied Trades.

10 GROUP HOLDS BOWLING BENEFIT

On Sunday, June 5th, the group Cure Diabetes Now (CDN) held a fundraiser at Lucky Strikes Bowling Lanes in Hollywood, CA. After an evening of bowling, food, silent auction and raffles, CDN President Steve Martini presented a check for $10,000 to the DRI to help further its important work toward a cure. Attending the benefit was California regional board member John Ratzenberger and his son, James. New York and Long Island SUPPORT ABOUNDS FOR CHILDREN’S BEST HOPE

More than 400 people from the New York metropolitan area attended the fourth annual Children's Best Hope for a Cure dinner, and enjoyed an elaborate cocktail reception, a sumptuous dinner, a sweep- stakes drawing with over 100 prizes, and a silent and live auction. From the begin- ning, the event has been a tremendous SERVING UP SUCCESS success, and this year's dinner was no Long Island’s hospitality industry served up another exception. Held on Thursday, April 7 at enjoyable day of golf and good cheer at the Long the Jericho Terrace in Mineola, and Island Hospitality Association’s Golf Outing, held at chaired again by Michelle and Peter the Garden City Country Club. Attempting to beat Bongiorno (left), the event raised the pro, pick up a mulligan, or get a hole-in-one, $330,000. Serving as Honoree was Carole the generous golfers emptied their pockets in Enisman (center), executive vice president support of the DRI. According to Co-Chairmen Jim of operations of Gilman Ciocia, one of O’Leary (left) of the St. James Restaurant and Mike Long Island's lead tax and financial Sweeney (right) of BK Sweeney’s Restaurants, the planning organizations, also pictured 15th annual event raised more than $50,000. with James Ciocia. $1 MILLION RAISED AT EMPIRE BALL

New York’s Real Estate Division helped to raise more than $1 million at the 2004 Empire Ball, which was held at the Grand Hyatt Hotel on December 1. The evening began with a speech by Peter L. DiCapua (right) of Atco Properties, chairman of the Empire Ball, and a memorable film about the DRI, hosted again by comedian and actor Ray Romano. The elegant affair honored Thomas Santiago (center), Northeast region head, Corporate Realty Services of CITIGROUP, who received the prestigious Empire Ball award from last year’s honoree Mark J. Marcucci (left) of Lehman Brothers. The Camillo Ricordi Humanitarian Award was presented to Frank J. Sciame, Jr., president/CEO of F.J. Sciame Construction Co., Inc. Last year’s recipient, Peter Marchetto, president of Bovis Lend Lease, presented the award to Sciame.

11 EVENTS

NOT JUST CHILD’S PLAY YOUNG PROFESSIONALS Most of the fundraising events for the DRI are centered on adults. There UNITE TO MAKE AN IMPACT are black-tie galas and intimate dinners, golf classics, tennis tournaments and the like, but at the Kids Party for a Cure, it’s all about the younger set. New York’s young professionals have an Immediate Priority: A Cure Today. Held at the New York Hall of Science, which features thousands of Otherwise known as IMPACT, the group held its second annual A Cure for Shore interactive exhibits and the world’s largest playground, the event raised at the picturesque Central Park Boathouse and raised more than $36,000. On a nearly $230,000. The love and dedication of two parents of a child with balmy evening, attendees danced the night away proving IMPACT’s dedication diabetes, Debra and John Carrion, together with their co-chairs, Cindy and to finding a cure. Chaired by Jennifer and Benjamin Hatz, the cocktail reception Mitchell Krupp, and a hardworking committee (pictured), made this attracted approximately 200 people. From sweepstakes sales to silent auction second annual event another huge success. bidding, all those who attended truly made an IMPACT.

New York/ Florida / California RESEARCH UPDATES HELD THROUGHOUT COUNTRY Some of the world’s leading scientists in diabetes research convened in New York to update families affected by the disease on the latest scientific breakthroughs. On October 23, approximately 300 people gathered at New York City’s Grand Hyatt Hotel for the 5th Annual New York Research Update, titled Transplantation, Tolerance & Regenerative Treatments. Attendees soaked in a wealth of information during a full day of presentations, discus- sions and breakout sessions and gained new hope after hearing from a number of islet cell transplant recipients. Pictured top: David Harlan, M.D., Luca Inverardi, M.D., Event Chairpersons Thomas D. and Dr. Denise R. Stern, Camillo Ricordi, M.D., Robert A. Pearlman, Bernard Siegel, Esq., Terry Strom, M.D., and Event Chairpersons Esther and Marc S. Goodman. On February 5, more than 200 people attended Florida’s 4th World of Hope conference, which was presented by JM Family Enterprises, Inc. and held at Boca Raton’s Muvico Palace. The half day program began with Dr. Ricordi detailing his “sequential, integrated approach” to finding a cure and continued with reports on islet transplantation, preventing islet rejection, the future of stem cell research, and early childhood events that shape the path toward or away from type 1 diabetes. The program concluded with inspirational stories from islet transplant recipients and a question and answer session with the entire panel. Pictured bottom: Antonio Secchi, M.D., Dr. Ricordi, Ezio Bonifacio, Ph.D., Norma S. Kenyon, Ph.D., and Juan Dominguez-Bendala, Ph.D. In California, Chairpersons Mary Bos, M.D., and Beth Braun, Ph.D., welcomed 100 guests to the Marina del Rey Marriott on June 14 to hear Dr. Norma Kenyon discuss the DRI’s groundbreaking work in islet cell transplantation. Cindie Gittelman, one of a growing number of the Institute’s islet transplant recipients, spoke poignantly about her experience.

12 LOOK INTO THE CRYSTAL BALL The Seventh Annual Crystal Ball was held April 16th, 2005 at the prestigious Garden City Hotel in Garden City, New York. Chaired by Risa and Jeff Pulver (right), the elegant affair included cocktails, dinner, dancing, a “casino,” and a live and silent auction, and raised more than $580,000. Serving as this year’s honoree was Melvyn B. Ruskin, founding partner of Ruskin Moscou Faltischek, P.C., and his wife, the Honorable Lea Ruskin (center), and as the 2005 Gillin Family Humanitarian was Martin Granowitz (left), a generous supporter of the DRI. Also pictured is Long Island board member, the Honorable C. Raymond Radigan (second from left). The Fund-A-Grant feature of the event raised more than $195,000, which included a generous match by the Stacy Joy Goodman Memorial Foundation.

Florida

PLAYERS TEE OFF AT THE DON STROCK DIABETES CLASSIC The 22nd annual Don Strock Diabetes Classic, presented by the Miami Seaquarium, raised almost $160,000, the highest take since the event’s inception. Held on May 18 at the Miccosukee Golf & Country Club, the event attracted more than 200 golf enthusiasts who joined former Dolphins Quarterbacks Don Strock and Dan Marino and other celebrity guests for a fun-filled day. During the dinner program, Danielle Most, 14, spoke of her personal battle with type 1 diabetes and her hope for a cure. Strock, head coach of the F.I.U. Golden Panthers, and Tournament Chairman Bruce Fishbein (standing, 2nd and 3rd from left) presented awards to tournament sponsors: (standing) Jaron Freeman, Lewis B Freeman & Partners; Jeff Pfaff, Top Tomato Company; Bruce Schumin, M & R Produce Distributors; Morris Corbitt, The Produce Connection; Adam Homan, Six L’s Packing Company; Doug Tannehill, C.H. Robinson Worldwide; Jim Yedo, Olympic Transfer Company; Doug Koban, Tropical Shipping; Robert Colescott, Southern Specialties; Sean White, Minuteman Press; John Marini, Heineken USA, (seated) Manny Chica, Crystal Springs; Terry Meeks, Coca Cola; Arthur Hertz, Miami Seaquarium; Joe Kettinger, Outback Steakhouse; Everett Miller, Taylor Farms of Florida; and Edmund Villacis, Comcast Spotlight. Not Pictured: Miccosukee Tribe of Indians of Florida, Riverside Fruit & Vegetables, Freedom Fresh, Sunkist Growers, Oppenheimer Group, Florida Mushroom, A-One-A Produce and Dairy, Von Kantor & Associates, Warren Henry Automobiles, Dole Fresh Vegetables, and American Fruit and Produce Corp.

13 EVENTS Florida

A PLEASURABLE EVENING PROFITS SOAR FOR A CURE During the fall season, Chef Norman Van Aken and More than 400 guests took off on a 15-minute flight event hosts Sue and Doug Gallagher (pictured with in an interactive flight simulator, and helped to raise Dr. Ricordi) welcomed approximately 100 fellow bon approximately $420,000 at Soar for a Cure. Held on vivants to Pleasures of the Palate, raising nearly January 22 at Aeroservice Aviation Center, a pilot $130,000. Guests were greeted with glasses of training facility near Miami International Airport, this bubbling champagne and passed hors d’oeuvres high-flying affair also included dinner, dancing and before sitting down to a four-course dinner perfectly live and silent auctions. Pictured: Chairmen Steve paired with the appropriate wines courtesy of National and Beatriz Wagman with Honoree Albert P.Wells Distributing Company. In addition to the delicious and Lucrezia and Vito La Forgia, Aeroservice offerings at NORMAN’S, highlights of the evening president and CEO. included the exciting live and silent auctions.

AN EVENING OF HOLLYWOOD GLAMOUR

At the 31st annual Love and Hope Ball, nearly 600 guests were given the star treatment as they arrived on red carpet for an evening of Hollywood Glamour. Held at the Westin Diplomat Resort & Spa in Hollywood, FL, the extraordinary affair, in combination with December’s Preview Party, raised more than $900,000. Life Chairman Sonja Zuckerman (top photo, second from right) offered special thanks to the evening’s true “celebrities,” Honorary Chairmen Sheika Kareeman and Sheikh Tarek Al-Fassi (right, with his daughter, Dima, center), Humanitarian Honorees Deborah and Dr. William Rand (left), Love Honoree Kathryn Nicolosi and Hope BOCA GOLFERS HIT THE LINKS Honoree Claudine Smurfit (shown in center Proceeds totaled more than $240,000 at the third annual Diabetes Research Institute Harold Kart Golf Classic. photo with Stephen Cermak and Jimmy Corpora), Nearly 350 golfers attended the November 15 event, which was held at the prestigious Boca West Country Club Silver Star Florence Frank (seated in bottom in Boca Raton. During the program, Co-chairs Gary Studley and Lou Steiner presented awards of appreciation to photo with Executive Chairmen Sandra and Sid top sponsors, including (l-r) Jerry and Donna Weiss, Gary and Rochelle Katz, Ruthann Beckerman, Jerry and Levy), and Preview Party Underwriter Isabel May. Debra Kramer, Myra and Allen Jacobson, and Sharon and Arthur Bearman, among others.

14 FASHIONABLE PHILANTHROPY Combining fashion with philanthropy, Saks Fifth Avenue Boca Raton presented the Chanel Spring/Summer 2005 collection to a crowd of 300 at a fabulous fashion show and luncheon in January. It was one of only four runway shows conducted by Chanel this year. Event Chairperson, Jill Viner, (center) offered special thanks to Esther and Marc Goodman (left) of the Stacy Joy Goodman Memorial Foundation, an event sponsor, DRI President and CEO Robert A. Pearlman, and Saks Fifth Avenue's Barbara Wolfson. WOMEN SHARE A GIFT OF LOVE... A GIFT OF HOPE

Led by Mariana Sherman (above, left) and Renee Aronin (above, right), the Palm Beach Auxiliary raised nearly $20,000 at the sixth annual A Gift of Love… A Gift of Hope Luncheon on February 7 at the Boca Woods Country Club. Two hundred women enjoyed an afternoon of boutique shopping and card playing while happily sharing the love of friendship and the hope of eradicating diabetes.

THE HEART OF LOVE AND HOPE REVELERS FEAST AMONG THE Charged with impassioned spirits and abounding GRAPES AND THE MARTINIS generosity, more than 200 guests attended the 31st annual Love and Hope Preview Party, held The 14th annual Feast Among the Grapes, in December 9 at the Diplomat Country Club, and cooperation with Wine Spectator, shook up tradi- contributed nearly $500,000. The evening was tion by stirring in eight specialty Van Gogh Vodka once again underwritten by the very generous martinis served up with sophistication from a Isabel May (pictured left with the Cocktail handsome oak bar. Held on June 4 at the new Reception Hosts Senator Paul and Sandy Steinberg). Radisson Hotel Miami, the soiree raised nearly $160,000. More than 1000 enjoyed an evening Those who made significant gifts that night of fine wines and spirits, gourmet cuisine from 30 included: Sheikh Tarek and Sheika Kareeman South Florida restaurants, a huge silent auction, KEY WEST POKER RUN – Al-Fassi, Dr. William and Deborah Rand, Claudine and dancing to live music by The Fit. A VIP cham- Smurfit, Kathryn Nicolosi, Sherman Simon, Isabel pagne reception sponsored by Rand Eye Institute A PETERSON TRADITION May, Penny and Robert A. Pearlman, Florence preceded the main event, and honored Olympic Frank, Sandy and Senator Paul Steinberg, Mark Once again, the Peterson clan (Phil Peterson, medalist Gary Hall, Jr, pictured center with his Rubin and Madelyn Rubin, Jane and Jerry center, with his sons, Dirk and Drew) organized wife, Elizabeth (2nd from right). Chairing the Goodman, Eleanor Kosow, Eleanor Lowe, Steven Phil Peterson’s Key West Poker Run, sponsored by event this year were Andy Waks (far left), David Posner, Sandra Smith, Helene Westreich and Sy Peterson’s Harley-Davidson of Miami and Harley- Walker, Barbara Amoils (front), Judy Waks (far Rosenblatt, Jana and Steven Sonberg, Gale Davidson South. What began more than three right), and Randy Furshman (not pictured.) Goldstein Tucker, Jacci and Dr. Floyd Seskin, decades ago has grown to become South Florida’s Drs. Carol Nudelman and Morton Blumberg, biggest motorcycle party weekend of the year. Cindy Carr, George Green, Barbara Herzberg, Approximately 20,000 riders rumbled from Miami Janie and Ronald Kupferman, Sylvia Kwasha, to Key West making five stops along the way to Sandra and Sid Levy, and Ruth Rosenberg. draw what they hoped would be a winning poker hand. Proceeds totaled $33,000.

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