ELISA kits and monoclonal antibodies for THE

MBL Classical Pathway Pathway Alternative Pathway H-Ficolin KIT 029 RIG 334 HYB 131 M-Ficolin ABS 036 C1-INH HYB 288 L-Ficolin C1q MBL/Ficolin ABS 005

C1q B

H2O C3 (H2O) Factor B C1s C1s C1r MASP-2 D ABS 002 MASP-1 HAV 005 C3 C3 (H O) B 2 Carbohydrate Carbohydrate GAU 010 C2 GAU 008 HYB 050 C2 C4 C3 (H2O) Bb Ba Factor Ba/b HYB 008 C3 (Factor P) HAV 004 C2b HYB 005 Properdin HYB 0393 C3d C4b2a HAV 003 C2a C4b HYB 030 C3bBb C4 HYB 162-04 C3a/C3a (desArg) C3 GAU 013 C3a C3a C4b GAU 017 HYB 162-02

C5 C4b2a3b C3bBb3b HYB 029 C5 - C9 C5a/C5a (desArg) Membrane attack complex GAU 025 HYB 268 GAU 018 C9 GAU 020 ABS 004 Lysis or phagocytosis of the microorganism C5b-9 Factor I DIA 011 HYB 061

Overview of the complement system. The name of the component and BioPorto Diagnostics' catalog number are shown in the blue boxes.

REFERENCES IN WHICH ANTIBODYSHOP PRODUCTS HAVE BEEN USED

C2 Cat. no. HYB 050 ∙ Rooijakkers SH, Ruyken M, Roos A, Daha MR, Presanis JS, Sim RB, van Wamel WJ, van Kessel KP, van Strijp JA (2005) Immune eva- sion by a staphylococcal complement inhibitor that acts on C3 convertases. Nat Immunol 6:920-7. ∙ Oh KS, Kweon MH, Rhee KH, Ho Lee K, Sung HC (2003) Inhibition of complement activation by recombinant Sh-CRIT-ed1 analogues. Immunology 110:73-9. ∙ Laich A, Moffatt B, Wong KHN, Hickling TP, Koch C, Sim RB (2001) Purifi cation of second component of human complement, C2, by antibody affi nity chromatography. Intern J Bio-Chromatography 6:151-162. ∙ Laich A, Sim RB (2001) Complement C4bC2 complex formation: an investigation by surface plasmon resonance. Biochim Biophys Acta 1544:96-112. ∙ Stenbaek EI, Koch C, Barkholt V, Welinder KG (1986) Human complement component C2: production and characterization of poly- clonal and monoclonal antibodies against C2. Mol Immunol 23:879-886. ∙ ∙ ∙ 039 HYB no. Cat. Properdin ∙ 131 HYB and 029 KIT no. Cat. MBL ∙ ∙ ∙ 018-03 GAU and 020-03 GAU no. H Cat. Factor and 010-04 GAU and 008-01 GAU no. DCat. Factor ∙ ∙ ∙ ∙ 162 HYB no. Cat. C4 ∙ ∙ ∙ ∙ ∙ ∙ 017-01 GAU 013-16 GAU and no. Cat. (desArg) C3a/C3a ∙ ∙ ∙ ∙ ∙ 004 HAV and 003 HAV no. Cat. C3 Denmark Gentofte DK-2820 8 Grusbakken A/S BioPorto Diagnostics For more information,pleasecontactBioPortoDiagnosticsoryourlocal distributor.

human monocytes. Eur J Biochem 219:759-64. JBiochem Eur monocytes. human in properdin of (1994) HW Expression Ziegler-Heitbrock KB, C, Reid MP, Claus M, HP, W, J, Strobel Dierich Huemer Most Schwaeble munol 158:4444-51. a positive regulator of complement activation, is released granules from of secondary stimulated peripheral blood neutrophils. J Im- WJ. (1997) P, J, Schwaeble Eggleton Properdin, KB, Reid North K, C, Whaley Stover MK, Schafer M, B,Thelen U, Dewald Wirthmueller mannose-binding lectin defi ciency and infection with Neisseriameningitidis. Mol Immunol 43:473-479. and properdin combined between Association P(2005) Wang K, P, C, Garred B,Koch Teisner H, Rasmussen Hansen L, Bathum 131. HYB or 029 fl KIT using reference MBL the view references of list Please yer, acomplete for 133:181-190. Methods JImmunol assays. immunosorbent by enzyme-linked (APC) complement of way path- alternative the of components of O(1990) C, Quantitation Gotze W, Kurts E, Gottsleben Brandt H, Baumgarten M, Oppermann 40:939-947. Int Kidney failure. renal in Ba fragment complement immunosuppressive the of O(1991) levels Gotze MH, E, plasma Weber Elevated Quentin R, C, Zierz Kurts M, Oppermann 24:119-134. Pharm Imm vivo. in activition complement of O(1992) U, Götze Assessment Höpken M, Oppermann plement activation. Mol Immunol 37:803-11. com- of pathway MBL the and classical the of Control (2000) JC T, C, Jensenius Koch Vorup-Jensen L, SV, Jensen S, Petersen Thiel binding of the pattern recognition molecules mannan-binding lectin, L-fi on bacteria pathogenic opportunistic of colin, and capsulation of H-fi Effect S(2005) JC, Thiel Jensenius M, colin. Infect Immun 73:1052-60. Matsushita UB, Sorensen A, Krarup groups and activates complement. Scand J Immuno 62:462-73. acetyl of patterns M-fi binds (2005) JC molecule, Jensenius CB, defence immune Larsen S, innate PD, an Thiel colin, Frederiksen print]. of ahead [Epub Immunol Mol cells. host dying of clearance the in participates and DNA recognizes Ficolin-2 P(2006) HO, Garred T, Madsen BE, Hansen C, Hummelshoj Honoré ML, Jensen 66:857-864. Wochenschr Klin B. Factor and C5, C3, proteins complement the of fragments of quantitation the through detected as failure renal with patients in activation O(1988) E, Götze Complement Quintin M, Haubitz M, Oppermann 40:939-947. Int Kidney failure. renal in Ba fragment complement immunosuppressive the of O(1991) levels Gotze MH, E, plasma Weber Elevated Quentin R, C, Zierz Kurts M, Oppermann 24:119-134. Pharm Imm vivo. in activition complement of O(1992) U, Götze Assessment Höpken M, Oppermann 30:935-940. Immunol Mol molecules. IgG human from M(1993) separeted Proteins Oppermann A, Freywald R, Nezlin 67:466-471. Chem Anal origin. bacterial of membrane acellulose by introducing system sor sen- glucose amperometric an of stability long-term the in S (1995) W, Improvement Eisele Göpel M, HPT, W, Ege Ammon Oppermann pends on complemet component C4. Kidney Int 53:1044-1051. Lhotta K, Würzner R, Kronenberg F, M, Oppermann König P (1998) Rapid activation of the complement system by cuprophane de- Immunogenetics 23:322-325. antibody. amonoclonal of by means detected C3 component complement human of N(1986) polymorphism Anovel C, Behrendt Koch the third component of human complement. Mol Immunol 24:1097-1103. in determinant signifi functional apolymorphic of and V,cance C(1987) Koch Localization Barkholt M, OC, Ploug Hansen N, Behrendt 172:1011-1017. Med Exp J C3. component complement human of ymorphisms pol of basis (1990) MJ Molecular C, Walport Koch KY, AK, Fong M, So Botto 156:3051-6. JImmunol humans. in levels C3 to circulating contributes C3 complement secreted (1996) MJ Extrahepatic Walport JM, GJ,Goldman MJ, Alexander Carter M, Botto MA, Naughton humans. J Immunol 162:4336-41. in pool circulating to the C3 complement secreted renal of (1999) SH RW, Contribution Sacks Vaughan NS, W,Tang Zhou S, Sheerin www.ngal.com Web 0001 4529 (+45) www.bioporto.com E-mail [email protected] 0000 4529 (+45) Fax Phone Distributed by:

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