Annual Report 1991 Federation of American Societies for Experimental Biology ?lie !federation's Purpose

MEMBER SOCIETIES q'o Ering togetfier researcli wor/(f.rs ana The American teacliers in e~erimenta{ Eio{ogy in tfie Physiological Society jie{as representea Ey tfie 9vlem6er Soci£ti£s for instruction in ana American Society for Biochemistry and el(c/iange of neW sci£ntijic Rgow{eage Molecular Biology in tfiese jiefasi to aisseminate

American Society for information on tfie results of Eio{ogica{ Pharmacology and researcli tfirougfi sci£ntijic puE{ications Experimental Biology ana sci£ntijic meetingsi to promote tfie American Association professional eaucation, training ana of Pathologists utilization of potential sci£ntists in tfie

American Institute jie{as of ~erimenta{ Eio{ogYi to of Nutrition represent tfie comtrWn sCkntijic ana eaucationa{ interests of tfie 9vlem6er The American Association of Immunologists Soci£ti£s as groUPi a{{ aevotea towaras aUfing tfie aevefopntmt ana utilization The American Society for Cell Biology of our country's sci£ntijic resources for tfie Eenefit ana wefjare Biophysical Society of our people.

Member Societies of the Federation

u.s. Canadian Foreign Total

APS 5,391 276 439 6,106 ASBMB 7,413 221 291 7,925 ASPET 3,093 116 158 3,367 AAP 1,797 93 62 1,952 AIN 2,101 93 185 2,379 AAI 3,727 154 651 4,532 ASCB 6,438 235 678 7,351 Biophysical Society 4,213 189 548 4,950

Total Members Duplicated as of December 31, 1991. 34,173 1,377 3,012 38,562 2 President's Report 3 Executive Director's Report 4 FASEB and The One Biology 6 The American Physiological Society Report 7 American SOciety for Biochemistry and Molecular Biology Report 8 American SOciety for Pharmacology and Experimental Therapeutics Report 9 American Association of Pathologists Report 10 American Institute of Nutrition Report 11 The American Association of Immunologists Report 12 The American Society for Cell Biology Report 13 Biophysical Society Report 14 Reports Continued 17 FASEB Public Service Award 17 Excellence in Science Award 183M Life Sciences Award 18 Gregory Pincus Memorial Award 18 Wellcome Visiting Professorships in the Basic Medical Sciences Award 20 Office of Public Affairs Report 22 Office of Scientific Meetings & Conferences Report 24 Office of Publications Report 26 Office of Placement Services Report 28 Office of Marketing Services Report 29 Personnel Services Report 30 Life Sciences Research Office Report 32 1991 LSRO Review & Evaluation Panel Participants 33 1991 Marc Program 34 Production Services Report 36 Comptroller's Office Report 40 Public and Congressional Testimony Presented in 1991 he first full year of activities these two societies demonstrated T of the "new Federation;' that the plans for selective de­ following the reorganization velopment of the Federation are conceived at the Williamsburg well-founded and effective. Ex­ Retreat in 1989, is about to ploratory discussions on mem­ come to a close. It is possible to bership are currently proceeding report that our experiment in with other societies, and pros­ governance reform is proceeding pects for continuation of the smoothly, with rewards for both renewed growth in Federation Member Societies and individual membership are encouraging. Robert J. Cousins society members alike. The Ex­ The Federation Office of Pub­ ecutive Officers, through the lic Affairs has the important Executive Officers Advisory tasks of focusing attention on Committee, now effectively pro­ the common interests of the vide direct input to important FASEB Member Societies, pro­ "FaT the first time in nearly decisions on Federation opera­ viding a unique forum for the 50 years, FASEB welcomed tions and policy. The major uni­ determination of consensus posi­ new societies to its member­ fying activity of FASEB is public tions on issues affecting the ship during 1991. The affairs. The newly established work of a wide range of bio­ American Society for Cell Public Affairs Executive Com­ medical investigators, and coor­ Biology and The mittee has been of tremendous dinating the independent public Biophysical Society . .. help. The Committee is made affairs initiatives of the Member up of one member representing Societies. Both the American So­ each society. These individuals ciety for Cell Biology and the have been very effective in con­ Biophysical Society have main­ sensus building on public policy tained an active interest in pub­ "The Federation Office of issues. During this past year, lic policy issues for several years, Public Affairs has the these issues have been among and the opportunity to enhance im portan t tasks of focusing the most difficult ever to con­ these activities by participation attention on the common front biomedical scientists. in the FASEB coalition program interests oj the FASEB For the first time in nearly 50 was a key issue in their decisions Member Societies." years, FASEB welcomed new so­ to accept membership. The out­ cieties to its membership during comes of the public affairs pro­ 1991. The American Society for gram draw strength from the Cell Biology accepted the invita­ diversity of participating dis­ tion to membership in July, and ciplines (now eight) and the size '1\s President for the Federa­ the Biophysical Society assumed of the combined Society mem­ tion du ring this very critical its place on the Board of Direc­ bership, now approaching 40,000 year. I can assure you that tors at the December Board scientists. This ranks FASEB as we are on the right course." meeting. These events high­ the largest biomedical research lighted a major segment of the organization in the world. transition process. The Retreat A full account of activities in had identified as one of its chief the Office of Public Affairs is ~bjectives the recruitment of given in another section of this new societies to Federation Annual Report, but three initia­ membership. The successful tives undertaken in 1991 demon­ completion of discussions with strate well the effectiveness of continued page 14 2 n important objective of the ment of Society meetings, and A FASEB reorganization is to implementation of the fee-for­ decrease the obligatory costs of service structure has encouraged membership. This is being Societies to seek assistance from achieved by a substantial reduc­ this group of well-experienced tion in annual dues, coupled professionals. The department with development of a fee-for­ managed six major national service structure providing Socie­ meetings and one international ties flexibility in selection of congress in 1991, and initiated services they choose to support. planning for thirteen events in A plan for financial restructur­ 1992. Michael J. Jackson ing was implemented in 1991 The response to the decision with encouraging results. Budg­ to convert The FASEB Journal eted dues revenue was decreased to voluntary subscription was by 15 percent below the assess­ most encouraging. Provided as a ment of the previous year. Fur­ membership benefit through "These and the many other ther reductions are planned each 1991, it was estimated that con­ examples of initiatives cited year through 1995, when an version to voluntary subscription throughout this Annual overall decrease of approximately would eliminate more than Report demonstrate that the 80 percent to the stable level of $300,000 of expenses from the new finanCial plan has $10 per individual society mem­ dues-base and provide Society potential to stimulate inno­ ber is targeted, and this rate is Members the opportunity to de­ [)ation , strengthen the offered to new Member Societies termine whether they wished to organization and improve joining FASEB before 1995. On receive the Journal. In fact, sub­ support provided to Member completion of this transition, scriptions are approaching 20 Societies. " dues revenues will be directed to percent of the membership for support of public affairs activi­ some Societies, a remarkable af­ ties, in which all Societies par­ firmation of the effective ticipate as a coalition. All other editorial policies of Editor-in­ services will be optional, fee­ Chief, Dr. William Whelan, and based activitieS. the Editorial Board in a five­ Full implementation of the year term, and ensuring a con­ fiscal transition will impact all tinued role for the Journal aspects of FASEB activities, and among the services offered by requires careful planning to en­ the Federation. sure that support provided to Recognizing a need for coordi­ Society programs is not com­ nation in offering fee-based ser­ promised. However, the ex­ vices, the Board of Directors in­ perience of the first year indi­ itiated an Office of Marketing cates that the plan is not only Services under the Direction of feasible but presents new oppor­ Ms. Linda Acuff. In addition to tunities for FASEB departments supporting activities of FASEB to serve the life science commu­ departments, Ms. Acuff and her nity. For example, the Office of staff provide assistance directly Scientific Meetings and Confer­ to Societies, and a well­ ences enjoys a well-earned repu­ coordinated program of advertis­ tation for excellence in manage­ ing sponsorship has already been continued page 14 3 The American Physiological Society

ounded in 1887, The Ameri­ cal research. In 1991, APS joined F can Physiological Society with five other FASEB member (APS) is devoted to fostering sci­ societies in Atlanta. The meeting entific research, with special em­ featured over 2,300 papers phasis on studying the ways the volunteered by APS members body functions, to education and and more than 35 symposia and to the dissemination of scientific workshops. In addition, our information. APS is dedicated to most prestigious lectures were "the advance of physiology and presented at the Spring Meeting. to facilitate personal intercourse W. Steve Ammons, Jefferson Norman C. Staub among American physiologists." Medical College, presented the President In fulfilling its mission, the annual Bowditch Lecture, and APS Council has re-emphasized Philip Needleman, Monsanto the role of physiology in in­ Company and Washington Uni­ tegrating heterogeneous ap­ versity, presented the Walter B. proaches in many disciplines Cannon Memorial Lecture. ranging from molecules to man, The APS publication program with the ultimate goal of under­ continued to prosper in 1991, standing how organisms function printing all the physiological at all levels, including molecules, research that was deemed worthy cells, tissues, and organs. The of publication. The APS editorial Council has encouraged the office encouraged the submission membership to utilize new tech­ of accepted manuscripts on disk nolOgical and conceptual ad­ in order to reduce the time to vances in order to provide an in­ publication. As a result, APS tegrative understanding of how published more than 27,000 Martin Frank Executive Director the body functions. pages and received over 5,000 During 1991, the integrative manuscripts in 1991. nature of the physiological sci­ APS publishes 13 journals in­ " . . . dedicated to "the ad­ ences was best exemplified cluding the American Journal of vance of physiology and to through the content of the Soci­ Physiology (available as 8 in­ facilitate personal in ter­ ety's scientific meetings and dividual sections and in a con­ course among American publications. The new APS Con­ solidated format), Journal of Ap­ physiologists. " ference format provided the plied Physiology, Journal of membership with a forum de­ Neurophysiology, Physiological signed to facilitate scientific ex­ Reviews, The Physiologist, and . APS Council has re­ change among researchers at the News in Physiological Sciences . emphasized the role of phys­ cutting edge of physiological The entire journal publication iology in integrating heter­ research. The 1991 APS Confer­ program involves the efforts of ogenous approaches in many ences were "From Channels to more than 850 scientists who dL~ciplines ranging from Cross Bridges" and "Interactions serve as editors and as members molecules to man, with the of the Endocrine and Cardiovas­ of the editorial boards. In addi­ ultimate goal of understand­ cular Systems in Health and tion, the APS has an extensive ing how organisms fu.nction Disease." book publishing program in con­ at all levels, including The annual FASEB meeting junction with Oxford University molecules, cells, tissues, and also prOVided a forum for APS Press. organs." to present the best in physiologi­ In 1991, the APS also con- continued page 14 6 American Society for Biochemistry and Molecular Biology

ne of the most striking de­ to clone the gene for each com­ O velopments in science in ponent to determine its primary recent years has been the ever­ structure from the nucleotide se­ increasing overlap in different quence and then to assess the fields. The broad area of bio­ effects of expressing the normal chemistry and molecular biol­ and mutated gene in cells. By ogy has become more vigorous bringing these approaches to­ and continues to build on new gether, we now have the best of discoveries in areas such as both worlds. chemistry, physics, biology and During the 1980's a myriad of genetics. In turn, the concepts important biological processes Minor J. Coon and techniques that were once were worked out at the phe­ President thought to be in the province of nomenological level. Such pro­ biochemists and their almost cesses include intracellular identical partners, molecular bi­ trafficking of proteins and ologists, are being applied ever li pids, gene-specific transcri p­ more widely in the biological tion, hormone and growth and biomedical sciences. In­ factor-induced signal transduc­ deed, it is virtually certain that tion, DNA replication, the cell future major advances in under­ cycle, protein folding, neuro­ standing the chemistry of living transmission and numerous organisms and of disease pro­ others. We need now to under­ cesses will involve "molecular" stand the molecular workings of insights. These can be gained these important processes. This only by elucidating the structure is our exciting challenge for the of living cells in the greatest years ahead. Charles C. Hancock possible detail and then apply­ The Society now has over Executive Officer ing this information to under­ 8,500 members. As with most standing the complex functions societies, its primary focus is on of living systems. scientific communication, In 1987 a decision was made through the Journal oj Biologi­ by the Society to put a stronger cal Chemistry and an annual . . it is Virtually certain emphasis on the field of molec­ meeting. However, several pro­ that future major advances ular biology, resulting in our grams have been initiated to ex­ in understanding the name change to the American pand the educational role of the chemistry oj livirtg organ­ Society for Biochemistry and Society. isms and oj disease processes Molecular Biology. This union Beginning in the fall of 1991, will involve "molecular' made good sense because the the Society began to organize insights. " two approaches to research are fall symposia on specialized complementary. The biochemist newly emerging topics. The first confronting a "new" biological such symposium, held in Key­ process develops a cell-free sys­ stone, Colorado, was on "Lipid tem to study the process quanti­ Modification of Proteins." All tatively and then proceeds to speakers were chosen from the resolve, purify and characterize abstracts submitted, with em­ its essential components. The phasis on younger investigators, molecular biologist's approach is including graduate students and continued page 15 7 American Society For Pharmacology and Experimen tal Therapeutics

he American Society for with the International Union of T Pharmacology and Experi­ Pharmacology in Montreal in mental Therapeutics (ASPET) is August 1994, ASPET will dis­ North America's professional so­ continue its Fall meetings and ciety for pharmacologists; its concentrate its efforts on a single membership includes most of the Spring meeting. Furthermore, pharmacologists in academia, in­ beginning in 1997, ASPET will dustry and government. Founded meet jointly with the American in 1908 to "promote pharmaco­ Society for Clinical Pharmacol­ logical knowledge and its appli­ ogy and Therapeutics and such Frank Standaert cation," ASPET has grown to its other societies as the two may President present size of 4300 members mutually invite. Coupled with and currently publishes four ASPET's thrust to expand its ef­ journals (The Journal oj Phar­ forts in basic pharmacology, par­ macology and Experimental ticularly in the newer molecular Therapeutics, Pharmacological aspects of the science, the joint Reviews, Molecular Pharmacol­ meeting will permit members of ogy, and Drug Metabolism and both Societies to participate in Disposition) and co-sponsors discussions of all areas of our another (Clinical Pharmacology discipline, from molecular to and Therapeutics). These are clinical. among the most widely cited ASPET also moved to serve scientific journals in the world. the needs of those working in Acutely aware of the rapidly emerging fields of the discipline changing world of science, by creating new divisions and ASPET this year initiated sections in Toxicology, Gastroin­ Charles O . Rutledge changes that will enable the So­ testinal Pharmacology, Immuno­ Secretary- Treasurer ciety to continue to fulfill the pharmacology, Cardiovascular mission envisioned by its Pharmacology, and Molecular Kay Croker founders. These changes encom­ Therapeutics. It is encouraging Executive Officer pass all aspects of scientific the formation of additional training, research opportunity regional chapters so that phar­ and the dissemination of science. macologists can meet con­ Recognizing the increasing veniently and inexpensively with . . lnembership includes mobility of scientists, the Society local colleagues. It is formulat­ most of the pharmacologists changed its by-laws to drop a re­ ing plans to encourage Divisions, in academia, industry and quirement for North America Sections and Chapters to hold government." residency. It also clarified the re­ meetings independently of ple­ quirements for membership to nary ASPET meetings so that ensure that newly trained inves­ pharmacologists may meet in , .. . ASPET this year in­ tigators and those trained in small groups to discuss highly itiated changes that will multidisciplinary approaches to specialized areas. The organizers enable the Society to con­ pharmacology would be wel­ of these meetings will be en­ tinue to fulfill the mission comed into the Society. couraged to bring the best of the envisioned by its founders." ASPET's most profound material to the attention of all changes are those for its plenary ASPET members by presenting meetings. After a joint meeting symposia at plenary meetings. continued page 15 8 American Association of Pathologists

uring 1991, the American Council as the result of their D Association of Pathologists deliberations that would result initiated several activities to in fundamental organizational bring the future into focus. AAP changes. These recommendations established a Publications Com­ will be put before the member­ mittee to complete two major ship in 1992 for their considera­ tasks within the year. The Com­ tion and approval. mittee served as the search com­ The society's meritorious mittee for Editor-in-Chief of awards are traditionally pre­ The American Journal of Pathol­ sented at the annual meeting. ogy and to solicit proposals for a C. Barry Pierce, a past-president Michael E. Lamm new publication contract. Dur­ of AAP and FASEB, received the President ing the process, the Committee society's Cold-Headed Cane in carefully evaluated current direc­ recognition not only of his mem­ tions and momentum and the orable contributions to research potential impact that changes in in fundamental cellular processes Francis A. Pitlick current arrangements might and neoplasia, but also highlight­ Executive Director have upon the publication and ing his excellence as a teacher and its readership. The current his commitment to public service Editor-in-Chief, Vincent within the profession. The Rous­ Marchesi, and the Associate Edi­ Whipple award was presented to tor, Jon Morrow, have made Harold Moses. This award is pre­ . . American Association major changes in the focus and sented to an AAP member who oj Pathologists initiated presentation of the journal's has sustained a career in several activities to bring the scientific content during their meritorious research with sub­ future into focus." outstanding 10 year service. In stantive contributions to the 1992, editorial responsibility will field. The significance of David transfer to Nelson Fausto and a Hajjar's discoveries in atheroscle­ new group of Associate Editors rosis and thrombosis were recog­ located at academic institutions nized with his selection as the across the country. winner of the Warner-Lamberti The AAP Council constituted Parke-Davis Award. This award a Long Range Planning Com­ is presented to an investigator mittee to advise it on a number who has not yet reached hislher of issues, including the gover­ 40th birthday but has already made nance structure of the organiza­ outstanding research contribu­ tion and liaisons with other soci­ tions. Finally, AAP presents the eties for future scientific Experimental Pathologist-in­ meetings. The Committee itself Training Award to a trainee (fel­ included a few members who low or resident) who has submit­ had served on the Program ted a particularly strong abstract Committee or Council, but was for consideration at the scientific formed with the goal of captur­ sessions of the meeting. This ing the perspective of younger year's winner was Frederic Barr. members and would-be mem­ AAP's Public Affairs Commit­ bers. This Committee has made tee was reorganized in 1991. This several recommendations to the committee has enabled AAP to continued page 15 9 he American Institute of tion techniques that stem from T Nutrition was founded near­ molecular and cell biology, bio­ ly sixty years ago with a twofold chemistry, and biophysics. purpose. As stated in its consti­ Hence, as concerns many of the tution, it would be a society "to basic research questions in nutri­ develop and extend knowledge tional science, AIN would like to of nutrition and to facilitate per­ encourage not only young aspir­ sonal contact between investiga­ ants who may undertake train­ tors in nutrition and related ing in our discipline as seen by fields of interest." It is the sec­ membership at any given mo­ Donald B. McCormick ond part of this purpose state­ ment, but also induce our col­ President ment that drives the first. Our leagues from other professional society recognizes that its bases backgrounds, who develop tech­ in science stem from and inter­ niques that we should adopt, to connect with other societies join with us in solving the largely within the FASEB struc­ numerous remaining problems. ture. This was true when AIN An especially important aspect became one of the early mem ber of nutrition, and one espoused societies over half a century ago by AIN, is its extension from the when much of physiology and basic to the applied. Just as especially biochemistry were our diverse methodologies are cur­ principal roots. With expansion rently used in nutritional of the numbers of societies, most science, and the systems we recently including cell biology study range from molecules to and biophysics, the contacts populations, it is the ultimate have appropriately increased. aim of most of us that our Richard C. Allison Modern nutritional science Executive Director knowledge can project to better utilizes the numerous technolo­ health for our species and those gies and approaches that have that support it. As stated else­ evolved into separately named where, it can be rationally ar­ "Our society recognizes that disciplines, many of which are gued that biologically we are the its bases in science stem from now or will become societies as­ sum result of genetic and nutri­ and interconnect with other sociated within FASEB. These tional events, other than for ac­ societies largely within the include a span from biophysics cidental (pathologic or physical) FA5EB structure." and biochemistry, through mo­ intrusions. The span and quality lecular and cell biology, to of our lives depend greatly on genetics and anthropology. It the ingestion and utilization of .. especially important should be obvious that strength­ nutrients. Hence, knowledge and aspect of nutrition, and one ening and enlarging upon cross­ application of nutrition con­ espoused by AlN, is its ex­ discipline interactions are of tinues to be of prime concern. tension from the basic to the mutual benefit. For example, the Within AIN we are discussing applied:' means by which an essential research interest categories that micronutrient gains facilitated may help focus some of our ef­ entry into a cell that exhibits forts, and also ways to bring specificity in its uptake is really together associated nutrition so­ a problem within the scope of cieties. In the same spirit, we nutrition, but requires for solu­ welcome the ongoing interac­ continued page 15 10 The American Association of Immunologists

mmunology as a distinctive tion. To cite just a few examples I field of study generally is from more recent times, immu­ considered to have begun about nologists or others using im­ 100 years ago, with the demon- munologic techniques were re­ ration in 1890 by von Behring sponsible for development of and Kitasato of serum factors­ powerful immunoassay technolo­ nO\\' known as antibodies-that gies, our current "fluid mosaic" conferred protection against paradigm of cell membranes, for tetanus toxin. Indeed, the field the elucidation of countless in­ is" so young that some of those tercellular messengers, and hom­ who first defined the principal ing molecules. The development Henry Metzger protein and cellular elements of of "abzymes" (made to order en­ President the imm une system are still zymes based on the virtually un­ ali\"e-and in a few instances limited potential of the antibody are still actively engaged in combining site), and immuno­ research. toxins (made to order cytolysins In keeping with its origins, a based on combining antibodies continuing theme of immuno­ and cell toxins) are just two ex­ logic investigations remains as amples of promising analytic or the prevention of infectious dis­ therapeutic tools whose extraor­ eases. Although public sanitation dinary potential are currently and private hygiene have con­ being actively explored. At a tributed much to limiting these more basic level, the continuing diseases, some of the worst study of the mechanisms used by .,courges of mankind require the immune system to distin­ more direct and specific inter­ guish self from non-self remains \·entions. Infectious diseases con­ as one of the most challenging Joseph F. Saunders Executive Director tinue to be the most common problems; its continuing study fi nal cause of death and the cur­ should give us profound insights rent epidemic of the acquird into how a complex biologic sys­ immune deficiency syndrome is tem is regulated. a somber reminder of how much Individual creative scientists "Infectious diseases continue remains to be done. have been the source of the ex­ to be the most common Although often using tech­ traordinary achievements in im­ final cause oj death and the niques developed in other dis­ munology and will always re­ current epidemic oj the ciplines early in its development, main so in the future. However, acquired immune defiCiency the field of imm unology began increasingly the conduct of syndrome is a somber to contribute to medicine, in science requires a professional reminder oj how much general, and to other fields of and administrative underpinning remains to be done. " biology. It is often forgotten to be able to do its work and to hO\\· primitive our concepts were see that its discoveries are used about the molecular bases of to promote human health. Con­ species differences, and the in­ temporary science requires sub­ \·e.stigations of blood group and stantial public financial support; immunologic cross reactions con­ it requires an efficient and tributed substanti\'eh' to our un­ responsive industry to manufac­ derstanding of molecular e\."olu- ture sophisticated equipment continued page 15 11 The American Society For Cell Biology

he American Society for scientists to Congress. ASCB's T Cell Biology (ASCB) was call for unity among various founded in 1961 to facilitate the representatives of the scientific study of cell biology by both en­ community has resulted in hancing communication among greater consensus among institu­ scientists and representing scien­ tional, administrative and scien­ tists' views to larger communi­ tific representatives. This coming ties. Membership in the Society together is crucial for the forma­ has grown steadily to over 8,000 tion of a clear, compelling mes­ regular, student and emeritus sage to Congress that minimizes Marc Kirschner members. self-interest and maximizes na­ President 1991 was a pivotal year for tional and human interest. the Society and its members. The attention of Congress to The Society reached milestones issues of basic biomedical re­ in public policy and scientific search is exemplified by the Bio­ publication affecting its own medical Research Caucus in the membership and the field of cell House of Representatives, which biology, as well as impacting will become a bicameral body basic biomedical research on a when it expands to the Senate in national scale. 1992. Many distinguished mem­ ASCB jOined FASEB as a full bers of ASCB have been asked member in 1991 and has joined to address members of Congress forces with the Federa tion to and their staffs to educate them maximize its voice in public on issues such as women's health policy, and to provide a wider and heart disease, helping Con­ scope of service to Society gress understand how basic re­ Elizabeth Marincola Executive Director members. search is essential to our ability Society management changed to achieve clinical advances in hands in 1991 with the resigna­ these and in every human, ani­ "1991 was a pivotal year jor tions of Dorothea C. Wilson, mal and plant disease area. the Society and its members. Executive Officer, and Rose­ More than sixty members of The Society reached In ile­ mary J. Simpson, Executive As­ Congress have joined the stones in public policy and sistant. Ms. Wilson and Ms. Caucus. scien fiJic publication affect­ Simpson had ably and loyally ASCB, with FASEB and other ing its biology, as well a served the Society for a decade. societies, worked closely with impacting basic biomedical Ms. Wilson was succeeded by congressional staff to achieve an research on a national Elizabeth Marincola, who was NIH funding level of $9.01 bil­ scale. " appointed Executive Director in lion for fiscal year 1992. The So­ August. ciety is advocating NIH funding at $10.47 billion for FY '93, "ASCB joined FASEB as a which would support a 30 % full member in 1991 and success rate equivalent to 6,233 has with the new and competing grants. The joined forces Public Policy Federation to maximize its Society is also concerned with voice in public policy. and The Society has taken a supportive policies at NIH that to provide a wider scope of leadership position in represent­ will promote investigator­ service to Society members." ing the views of active bench initiated research. continued page 16 12 ormation of the Biophysical medical research and training. F Society was initiated at the Involvement of the Biophysical 1956 FASEB meeting to bring Society with the FASEB Office together biophysically oriented of Public Affairs complements physicists and physiologists who our joint congressional educa­ were moving into fields beyond tional effort with the American the boundaries of the established Society for Biochemistry and scientific societies. With fore­ Molecular Biology (ASBMB) and sight, the founders of the Bio­ the American Society for Cell physical Society recognized that Biology (ASCB). The Congres­ the scope of this science could sional Biomedical Research Cau­ Donald L. D. Casper not be constructively delimited. cus, supported by this joint in­ President Biophysics has been dynamically itiative, has helped to inform defined by the scientists who Congress about achievements identify themselves as biophysi­ and prospects in biomedical re­ cists. We share a common con­ search and the significance of cern for application of quantita­ NIH-funded, investigator­ tive methods to the analysis of initiated research projects in at­ biological systems ranging from taining nationally important molecules to populations. Bio­ goals in health sciences and bio­ energetics, contractility, mem­ technology. brane biophysics, and molecular Student symposia at our An­ biophysics are topics of particu­ nual Meetings and the brochure lar current interest, with increas­ on "Careers in Biophysics," pre­ ing concentration on molecular pared by the Education Com­ mechanisms of biological action. mittee, are designed to inform Emily M. Gray Much of this science was unan­ high school students of achieve­ Executive Director ticipated when our society ments in Biophysics that will started; and we continue to positively affect their lives and, evolve, fostering investigation of furthermore, to help motivated productive fields and exploration students apply their creative tal­ "Expansion of the activities of new frontiers of biology. ents in basic biomedical research. of the Biophysical Society in By accepting the invitation of At our 1991 Annual Meeting, serving the needs of our the Federation Board this past the more than 2400 contributed members and OUT Count7'y is year to join the recently reor­ abstracts and the 12 symposia being facilitated by ou r ganized FASEB as its newest surveyed the current scope of affiliation with the Federated member society, the Biophysical Biophysics encompassing mole­ Societies in FASEB. ' Society can now better represent cules, membranes and motility. the interests of our members, Our 1992 joint meeting with particularly in critical public ASBMB has a strong emphasis policy issues of concern to all on proteins, their structure, dy­ scientists involved in biomedical namics, activities and adapta­ research. Coordination of public bility. policy initiatives by FASEB pro­ The Biophysical Society pub­ vides effective representation of lishes the Biophysical Journal the member scientists to advo­ and the Biophysical Discussions. cate constructive support of bio­ The Biophysical Journal has ex- continued page 16 13 President from page 2 critical year, I can assure you that strengthen the organization and im­ we are on the right course, albeit prove support provided to Member this program. These were the some course corrections may be Societies. Achievement of the fiscal FASEB consensus conference, "Pro­ necessary from time to time in the objective presents a valuable oppor­ posed Reforms of the Indirect Cost future. The progress achieved in tunity for the Federation to en­ System;' held in June, the coordi­ 1991 is highly encouraging, and hance all aspects of its activities. nated responses to the proposed lends confidence to the view that regulatory reforms relating to proce­ the Federation will continue to serve dures used in the Office of Scientific the biomedical research community Integrity in resolving allegations of as well in the 21st century as it has scientific misconduct, and the Office in the 20th. APS from page 6 of Government Ethics guidelines af­ fecting the participation of govern­ tinued to expand its efforts in edu­ ment scientists in professional soci­ cation, both at the college and pre­ ety activities. In each case, the college levels. APS sponsored 11 activities coordinated through the Executive Director from page 3 teachers to work in members' FASEB Office of Public Affairs en­ laboratories as part of the High sured that the concerns of working implemented for several parti­ School Teachers Summer Research biomedical scientists were directly cipating Society publications. Program. The Society also hosted represented and timely enough to In response to requests from the approximately 100 under­ influence the policy development scientific community, and to facili­ represented minority students for process. tate development of interdisciplinary an outreach program held in con­ In April, the six founding Mem­ opportunities, the Federation pro­ junction with the APS Conference ber Societies (APS, ASBMB, ASPET, vides core management support for in San Antonio, Texas. AAP, AIN, AAI) held the last con­ nonmember associations in the area APS continued to prOVide pre­ joined scientific meeting under the of experimental biology. These serv­ and postdoctoral support to minori­ FASEB umbrella, ending a tradition ices include secretariat support and ties pursuing research in physiology extending back to 1913. More than newsletter distribution, dues collec­ through our highly successful Port­ 13,000 scientists, including nearly 30 tion and subscription fulfillment, er Physiology Development Pro­ percent of the combined member­ and financial management. In addi­ gram. In addition, the program ships of the Federation Societies, tion, management support may be provides support for instructors to gathered in Atlanta to mark the end provided for scientific meetings and teach physiology at the of this chapter. In the future, the conferences, publications, placement predominantly black institutions in Societies will meet separately, or and marketing. In 1991, societies us­ Atlanta and New Orleans. The together in groups reflecting mem­ ing Federation association manage­ Porter Program, with support from bership interests. While many ment services included: the NIDDK , coordinated a pro­ FASEB society members desire the gram to bring both minority stu­ larger meeting, the intention is to The American Society for dents and faculty to the scientific provide Societies a level of flexibility Neurochemistry meetings of APS . in structuring scientific programs of The International Society for the The above represents only a frac­ their meetings that is more difficult Study of Xenobiotics tion of the SOciety's activities in to achieve with the coalition format. The International Society on 1991. It does, however, provide a The voice of the Federation on Thrombosis and Hemostasis picture of a dynamic, effective and relevant issues is louder and more The Protein Society vigorous society striving to fulfill unified than in the past and, conse­ The Society for Cryobiology the needs of its membership and quently, we have a significant The Society for Invertebrate the research community. In order responsibility to the biomedical Pathology to continue to serve the community research enterprise. The develop­ The Society for Leukocyte Biology effectively, the APS needs the ac­ ments I have mentioned, and those The Society for Molecular Recog­ tive participation of the member­ described in other sections of this nition ship in its publications, meetings, Annual Report, demonstrate that committees and other activities. FASEB is proceeding with the These and the many other exam­ Together, we can ensure a bright implementation of its new mission ples of initiatives cited throughout future for physiology and the APS . with determination and conviction this Annual Report demonstrate to meet that challenge. As President that the new financial plan has for the Federation during this very potential to stimulate innovation,

14 ASBMB from page 7 scientists. The Society also initiated Institutes of Health, or other feder­ a program to support college stu­ al agencies. The regulations would postdoctoral fellows. Three such dents doing summer research in limit participation in society activi­ small symposia will be held in the pharmacology laboratories and be­ ties and would impair the ability of fall of 1992 with the following gan a program to seek out and at­ these members to lead a full profes­ topics: "GTP Binding Proteins and tract minority students to careers in sional life with an academic focus . Vesicular Transport in Eukaryotic pharmacology . A second issue on which AAP Cells," "Molecular Chaperones: In addition to these long range presented a position was to respond Function in Protein Folding and efforts, ASPET engages in short to the NIH proposal "Management Cellular Metabolism" and "Cellular term projects to ensure the health of Research Costs: Indirect Costs." Regulatory Mechanisms Involving of the discipline by operating a In public testimony, AAP discussed Phosphorylation and professionally staffed public affairs the role of unlimited construction Dephosphorylation. " office. This office monitors perti­ in increasing the indirect cost rate The Society provides funds to nent activity in the Congress, NIH, and requested that recovery of fa­ enable high school teachers to ADAMHA and FDA and arranges cilities costs be based upon pre­ spend summers in members' labora­ for officers and members to testify determined criteria for need. tories. This program is intended to or participate in discussions with Once again, AAP offered its provide teachers with insight into the staffs of these organizations on popular continuing education the exciting opportunities in a budgetary and other matters. course, Concepts in Molecular Biol­ research laboratory and improve One of ASPET's most important ogy. Participants reflect a variety their teaching skills. concerns is safeguarding the ability of professional interests, including Other programs include work­ to use animals in research. While many outside pathology. While shops for teachers from high the issue affects all of biology, it young pathologists are well­ schools with predominantly minori­ impacts directly on the advance­ represented among the students, ty populations. Through this pro­ ment of pharmacology. Ours is in­ immunologists, microbiologists, and gram, we hope to increase the pool herently an integrative science in other biological scientists, both of students from under-represented which the effect of drugs on whole junior and senior, find the course minority groups who might con­ organisms is all important; it to be exceptionally helpful in un­ sider biomedical research a viable would not be possible to continue derstanding the intricacies of this career option. to bring new drugs to benefit essential area. AAP's Education animals and human beings without Committee is now planning addi­ the ability to do whole animal tional courses on other topics of research and toxicity testing. We potential interest to a similar believe that the research must be group. ASPET from page 8 done carefully and with respect for the subjects, but we believe it must To help ensure the future supply be done. Accordingly ASPET has a of personnel trained for research, special committee on The Care and ASPET commissioned the production Use of Research Animals and has AIN from page 10 of posters, brochures and a video taken the lead in many struggles to tape designed to attract college stu­ tions with our colleagues in the preserve this irreplaceable means to broader sphere of biological and dents to careers in pharmacology. A conduct research to improve biomedical sciences represented by similar program to attract high health. school students to careers in research FASEB. is well advanced. Like the former, this will feature a specially made videotape and a roster of speakers AAP from page 9 who will talk to students at their AAI from page 11 schools. respond substantively to two issues ASPET also supports the educa­ of particular interest to its mem­ and reagents; it requires mechan­ tion of those students already com­ bers. One issue regarded proposed isms for the rapid dissemination of mitted to pharmacology. It has regulations for ethical behavior of ideas and for creating suitable long had a program to fund gradu­ government employees that would forums in which these ideas and ate student travel to our meetings. result in severe constraints on mem­ observations can be critically ap­ Recently we expanded it to include bers who are employed by the praised. It also requires increased postdoctoral students and young Veteran's Administration, National public understanding but not only

15 to engender public financial sup­ Annual Meeting: The 1991 annual improve efficiency of publication, port. There are those who would scientific meeting of the Society information transfer, and visualiza­ retard the growth of science be­ was held in Boston, and drew over tion of three-dimensional cause of well-meaning but un­ 10,000 attendees, including over structures. founded fears; similarly, there are 7,000 scientists. The meeting fea­ An issue of concern in the ex­ those who may be too ready to ap­ tured over 3,000 presentations of panding field of Structural Biology ply the increasingly powerful tools original research on topics includ­ has been the diminishment of and products of science without ing cell cycle, gene regulation, de­ resources for neutron scattering sober consideration of the conse­ velopmental biology and plant studies as other facilities, in partic­ quences. Finally, the progress of development. ular advanced synchrotron sources, immunology and the other sciences are being productively developed. requires a continuing influx of en­ Society Committees: Among the The Biophysical Society has estab­ thusiastic, well-educated young in­ many activities of the Education lished a Neutron Structural Biology vestigators. Committee, ASCB continues to Task Force to advise the Depart­ Support of these ancillary activi­ sponsor the Summer Research ment of Energy regarding construc­ ties forms the high purpose of Teacher Fellowship program, tive development in this area of professional Societies like The bringing secondary school teachers Structural Biology. American Association of Immunolo­ into the laboratories of Society ExpanSion of the activities of the gists. Through its Journal oj Immu­ members for several weeks. The Biophysical Society in serving the nology, its Annual Meeting, its Society also hosted a two-day con­ needs of our members and our Education and Public Affairs Com­ ference on pre-college science edu­ country is being facilitated by our mittees, its participation in the In­ cation, designed to teach teaching affiliation with the Federated Soci­ ternational Union of to scientists. Both programs are eties in F ASEB. Our society office Immunological Societies (and its supported by grants from the Na­ on the F ASEB campus, under the Congresses, Nomenclature, Stan­ tional Science Foundation. direction of Emily M. Gray, is ex­ dardization and Symposia Commit­ Other productive committees of panding to deal effectively with the tees) and in FASEB , the AAI is the Society include Minorities Af­ increased responsibility of manag­ attempting to provide such suport. fairs, which sponsors minority trav­ ing the scientific and public policy In the future the continuing in­ el grants and scholarships; Public initiatives of the Biophysical volvement of the membership in Affairs, which oversees the Legisla­ Society. such activities will be critical if the tive Alert Committee; and Public Society is to perform its tasks effec­ Information, which works with tively. science writers to educate the general public on scientific issues. FASEB and the One Biology from page 5 academia and policymakers in government look to obtain the edu­ Biophysical from page 13 cated perspective of the working scientist in biomedical research. panded to over 2900 pages in 1991 ASCB from page 12 and is continuing to grow in order to serve the interests of our mem­ Publications: The Society channeled bers. There is increasing emphasis new energy into its scientific jour­ on molecular biophysics, reflecting nal, modified and re-named advances in this field, and a new Molecular Biology oj the Cell. focus on biophysics education. Editor-in-Chief David Botstein and Electronic means of publishing are ASCB President Marc Kirschner being developed through joint sup­ attracted and enlisted an outstand­ port of an Innovative Technology ing editorial board; submissions to Fund with the Protein Society and and subscriptions for the journal the ASBMB. This technology will indicate that it will achieve its first be applied by the new journal promise and, together with the Protein Science, published by the Journal oj Cell Biology, serve and Protein Society, and will be used enhance the field of cell biology. by the Biophysical Journal to

16 with surgical pioneer Alfred Blalock in developing many surgical procedures. McCabe has a bachelor's and master's degree in English from the University of Maryland and is a former teacher of English and journalism. The FASEB Board makes an annual Public Service Award to individuals who have made out­ standing contributions to the cause of biological and medical research through achievements in nonscientific fields.

-;:::::­ Excellence In Science Award §.~ Ellen S. Vitetta, Ph.D., who holds the Scheryle Sim­ Katie McCabe Receiving the 1991 FASEB Public Service mons Patigian Distinguished Chair in Cancer Im­ Award from FASEB President Tom Edgington. munobiology at the University of Texas Southwestern Medical Center at Dallas, Texas, received the 1991 FASEB Excellence in Science Award for her innova­ FASEB Public Service Award tive contributions to the field of Immunology. Her lec­ ture entitled "Antibody-Toxin Conjugates: A Round­ Writer Kathleen (Katie) McCabe was the Trip Voyage from the Lab to the Clinic," was presented recipient of the FASEB 1991 Public Service at the FASEB Annual Meeting in Atlanta, Georgia. Award. The award presentation was made at a Dr. Winston S. Marshall, a Lilly research scholar, Federation Board reception during the FASEB presented the $10,000 award. The annual Excellence Meeting in April 1991. in Science Award and Lecture is sponsored by Eli Lilly and Company and is designed to identify superior FASEB President, Thomas S. Edgington, MD, research in biomedical science. Dr. Vitetta is a mem­ presented McCabe with the award and noted that ber of the American Association of Immunology through her articles, McCabe had provided a Council. demonstrable public service by clearly identifying and communicating to the public the fallacies of the animal rights movement. McCabe wrote two articles for Washingtonian magazine on the animal rights movement and its effect on the biomedical research movement ("Who Will Live? Who Will Die," August 1986; and "Beyond Cruelty," February 1990) . In receiving the award, McCabe said she be­ came interested in the animal rights movement af­ ter witnessing protesters on the campus of the National Institutes of Health near her Bethesda home. McCabe's first animal rights article was a finalist for the 1987 National Magazine Award. McCabe won the 1990 National Magazine Award for Best Feature for an article on Vivian Thomas, Ellen S. Vitetta, Ph.D. Receiving the FASEB Excellence in a highschool educated carpenter who collaborated Science Award.

17 3M Life Sciences Award

Allan C. Wilson, Ph.D., of the University of Califor­ nia at Berkeley was named recipient of the 1991 3M Life Sciences Award for his pioneering research on molecular genetics in relation to evolution. Dr. Wil­ son was a professor of biochemistry at the University at the time of his death in July 1991. He was a mem­ ber of the American Society for Biochemistry and Molecular Biology. Dr. Wilson was presented the Award in April at the Federation's Annual Meeting in Atlanta, Georgia, where he delivered the 3M Lecture "Mitochondrial DNA and Human Evolution." Dr. Gregg K. McPher­ son, Director of the 3M Biosciences Laboratory, presented the $25,000 award. The award is sponsored and funded by the 3M Company of St. Paul, Min­ The Late Dr, Allan C, Wilson Receiving the 3M Lije Science nesota, and the recipient is selected by the FASEB 3M Award j rom Dr, Gregg K, McPherson, Director oj 3 M's Bio­ Life Sciences Award Committee. ciences Laboratory,

Gregory Pincus Memorial Award Wellcome Visiting Professorships In In 1974 Mrs. Gregory Pincus The Basic Medical Sciences established a Memorial Fund in the Federation in honor of her Sponsored and supported by Each Visiting Professor late husband, a distinguished the Burroughs Wellcome Fund, spends 2-5 days at the host repro­ the Federation administers the institution engaged in teaching ductive physiologist and co­ and discussion with students discoverer, with Dr. M. C. annual Wellcome Visiting Chang, of the oral contraceptive. Professorships in the basic medi­ and faculty and delivers a Well­ Upon her death in 1988, she be­ cal sciences. Awarded to come lecture on a subject queathed additional monies to accredited degree-granting med­ related to his or her discipline. the Memorial Fund. Each year ical schools, universities, and The Burroughs Wellcome the President of FASEB selects a other scientific research institu­ Fund provides $1,500 to each student to receive income from tions within the United States, host institution for presentation the Fund to help defray expenses the Professorships are designed to the visiting professor, with an for travel to the Annual Meeting to stimulate interest in the basic award to the awardee institution or another scientific meeting of sciences and to recognize emi­ for attendant expenses. The his or her choice. In 1991 Dr. nent scientists in physiology, professor is also reim bursed for Thomas S. Edgington, President biochemistry and molecular his or her travel expenses as well of FASEB, selected Frederic G. as for an accompanying spouse. Barr of the Department of biology, pharmacology, pathol­ Pathology, Hospital University of ogy, nutrition, immunology, and Meals and lodging are provided Pennsylvania, to at­ cell biology. by the institution. tend the Annual Meeting in At­ lanta, Georgia.

18 Wellcome Visiting Professorships in the Basic Medical Sciences

Host Institution Visiting Professor .­ Creighton University Jared M. Diamond, Ph.D. Cell Biology UCLA Medical School East Tennessee State University David Shepro, Ph.D. Physiology Boston University Eastern Michigan University Dale Oxender, Ph.D. Cell Biology Warner-Lambert/Parke Davis Georgetown University G. V. R. Born, FRS. Pathology William Harvey Research Inst. Indiana University Steven L. McKnight, Ph.D. Biochemistry/Molecular Biology Carnegie Institution of Washington Loyola University Barbara Birshtein, Ph.D. Immunology Albert Einstein College of Medicine Marshall University Neil Nathanson, Ph.D. Biochemistry/Molecular Biology University of Washington Medical College of Wisconsin Alfred G. Gilman, M.D., Ph.D. Pharmacology University of Texas, Dallas Meharry Medical College John G. Hildebrand, Ph.D. PhYSiology University of Arizona North Dakota State University George C. Fahey, Ph.D. Nutrition University of Illinois, Urbana Oregon State University Willard J. Visek, M.D., Ph.D. Nutrition University of Illinois, Urbana Texas A&M University Ian R. Mackay, M.D. Immunology Monash University, Australia Texas Tech University Phil Skolnik, Ph.D. Pharmacology National Institute on Diabetes, Digestive and Kidney Diseases University of Alabama David Kritchevsky, Ph.D. Nutrition Wistar Institute University of Kentucky Susan Leeman, Ph.D. Physiology University of Massachusetts University of Louisville Joram Piatigorsky, Ph.D. Biochemistry/Molecular Biology National Eye Institute University of Rochester Susan S. Taylor, Ph.D. Pharmacology University of California, San Diego University of Virginia James C. Smith, Ph.D.

~ Cell Biology National Institute for Medical Research Virginia Commonwealth University Harriet C. Isom, Ph.D. Pathology Pennsylvania State University Wayne State University Richard Weinshilboum, M.D. Pharmacology Mayo Medical School Yale University Nicholas Wright, M.D., Ph.D. Pathology University of London

19 Gar Kaganowich Director

he Office of Public Affairs 1992 budget and increases for of Texas Health Science T (OPA) provides FASEB soci­ the Alcohol, Drug Abuse, and Center, Houston, and Elliot S. eties with thorough analysis and Mental Health Administration, Vesell, Penn State College of coverage of federal biomedical 2) the stabilization of new and Medicine, for ASPET; Joe W. research policy issues, coordi­ competing NIH grant awards Grisham, U. of North Caro­ nates the FASEB public affairs beginning with 6,145 in fiscal lina, for AAP and FASEB; program, provides support to the 1992 and 3) increases in the Patricia B. Swan, Iowa St. societies and builds coalition ef­ number of research trainees as University, and Buford L. forts. Having been billed as the recommended by the National Nichols, Baylor College of Federation's "eyes and ears on Academy of Sciences. Medicine, for AIN; Richard G. the federal government," the • In February, OPA assisted AAI Lynch, U. of Iowa, and Galen OPA maintains daily contact in a retreat for its Committee Toews, U. of Michigan Medi­ with key members of Congress, on Public Affairs in Miami cal Center, for AAI; Bruce M. their staffs, and executive branch Beach. Alberts, U. of California, San agencies in carrying out its as­ • In April, OPA assisted FASEB Francisco, and Cori Barg­ sistance to the societies. President Dr. Thomas S. Edg­ mann, MIT, for ASCB; and The OPA works to enhance ington, Scripps Research Insti­ Susan A. Gerbi, Brown Uni­ the role of the FASEB president tute, La Jolla, Calif., with his versity, for ASCB, ASBMB, as a spokesman for biomedical testimony before the House and the Biophysical Society. research. It receives its working Health and Environment Sub­ • OPA managed the press room priorities and direction from the committee on the indirect at the FASEB Meeting in At­ Federation Board and the Public costs issue. lanta. Several FASEB society Affairs Executive Committee. • Research funding was heavily members had their research The OPA also assists AAP , AIN, supported by FASEB society featured in USA Today , the and AAI with specific public af­ members in April and May in Atlanta Constitution, the fairs services. testimony before several House Dallas Morning News, and OPA support includes arrang­ and Senate appropriations sub­ other newspapers. At the ing for FASEB and society committees. The members tes­ meeting, Dr. Edgington pre­ representatives to testify before tified on the FY 1992 appro­ sented writer Katie McCabe congressional committees and ex­ priations for NIH, ADAMHA, with the FASEB 1991 Public ecutive agencies, arranging visits NSF, NASA, USDA, and the Service Award, a Steuben with congressional staff and ad­ FBI (which focused on vandal­ Glass Eagle, for magazine fea­ ministration officials, and ism by animal rights groups). tures she wrote about the providing research and analysis FASEB OPA assisted with the animal rights movement. The of legislation and public policy preparation of testimony by FASEB OPA also arranged for proposals. several witnesses and arranged APS and ASPET members to for some to meet with con­ be guests on a local radio talk gressmen, senators, and their show discussing animal Public Affairs Highlights of 1991 staffs. The congressional wit­ research issues. nesses included Drs. Edging­ • FASEB OPA organized the sec­ • FASEB began the year by ton for FASEB; Martin Frank, ond 1991 Consensus Confer­ sponsoring a Consensus Con­ APS executive officer, for APS; ence in June to focus on the ference on Biomedical Re­ Howard K. Schachman, U. of indirect costs issue. The con­ search Funding for Fiscal Year California, Berkeley, and ferees called for more unifor­ 1992 and Beyond. The report Harold E. Varmus, U. of Cali­ mity in indirect cost reim­ issued by the conferees called fornia, San Francisco, for bursement, and emphaSized for: 1) a $9.7 billion NIH FY ASBMB; Thomas F. Burks, U. that several principles should

20 be observed when reforming Office of Government Ethics' American Society for Cell Bi­ the system: 1) Indirect costs (OGE) proposed regulations ology and the Biophysical So­ are a necessary cost of re­ for federal employees' ethical ciety, which joined the Federa­ search, 2) those costs should conduct, including a section tion in June and December, not be shifted to direct costs on participation in profes­ respectively. They are the first categories, and 3) the system sional associations. Cousins ar­ additions to FASEB in nearly should be simplified to reduce gued that the restrictions half a century. negotiations and reflect the would make federally em­ • Throughout the year, OPA actual costs of research. The ployed researchers second-class sponsored monthly public af­ conferees also supported an scientists by making it difficult fairs briefings for society ex­ OMB proposal identifying un­ to engage in opportunities that ecutives and public affairs allowable costs, many of professional associations staff to update them on the which have been well publi­ provide. latest developments in research cized following congressional • FASEB's third Consensus Con­ public policy. Featured investigations. ference of 1991 dealt with speakers have included • Following the Consensus Con­ funding at NIH and ADAMHA Research!America President ference, OPA assisted Dr. Edg­ for FY 1993 and beyond. The Mary Woolley and NIH Plan­ ington with his participation conferees revised and extended ning and Policy Research in a high-level OMB-OSTP the long-range recommenda­ Branch Chief Dr. Norman S. meeting with university offi­ tions of the February confer­ Braveman. cials to discuss reforms to the ence. The new recommenda­ In 1992, the Office of Public indirect costs system. tions included: 1) a $10.47 Affairs will pick up where the • New FASEB President Dr. billion FY 1993 budget for 1991 initiatives left off. It has Robert J. Cousins, Director of NIH, 2) a 30 percent success redesigned the FASEB Newslet­ the Center for Nutritional rate on new and competing ter and the Legislative Summary Sciences at the University of awards, 3) 6,233 new and to better communicate with so­ Florida, notified FASEB soci­ competing awards at NIH and ciety members. It has more con­ ety members of proposed sci­ 857 at ADAMHA, 4) increases sensus conferences in the plan­ entific misconduct rules issued in the number of pre- and ning stages. Preparations are also by the Public Health Service's postdoctoral trainees by 7.5 being made for congressional Office of Scientific Integrity and 2.5 percent, respectively, testimony on FY 1993 funding, Review (OSIR). Cousins alerted and 5) that any initiatives and more will be heard about the FASEB society members to created by NIH's proposed the indirect cost issue. Where many flaws in the proposed Strategic Plan be supported by 1991's public affairs program policy including: 1) Scientists funding above and beyond the was one of the busiest in would have no opportunity to $10.47 billion recommended. memory, 1992 promises to be confront accusers, cross­ • OPA assisted AIN president­ even busier. examine witnesses or request elect Dr. Dale Romsos in De­ an open hearing. 2) Accused cember in visiting more than a scientists' names would be put dozen congressional staff on the PHS ALERT system members and officials at OMB even before guilt was estab­ and the USDA to discuss lished. 3) PHS reserved the nutrition research funding for right to change the rules NIH and USDA. without public comment or • OPA assisted FASEB President­ notice. FASEB society mem­ elect Dr. Shu Chien, U. of bers inundated the OSIR California, San Diego, with office with more than 1,600 testimony before an NIH Advi­ letters. As a result of the out­ sory Committee hearing on in­ pouring of criticism, the pro­ direct costs proposals. APS, posal may undergo substantial ASBMB, and AAP also sent change. representatives to testify. • OPA helped Dr. Cousins and • OPA handled press announce­ several society representatives ments for the addition of two to prepare comments on the new corporate members, The

21 Office of Geri Goodenough Seien tifie Meetings Director & Conferences

he Office of Scientific Meet­ tries represented. The partici­ The Office of Scientific Meet­ T ings and Conferences pants found the meeting to be a ings has contracted to provide (OSMC) experienced another valuable medium for the ex­ meeting and exposition services year of remarkable growth in change of information among for the future annual meetings 1991. human geneticists from around of the Society for Leukocyte Biol­ The FASEB Annual Meeting the world. The exposition of 153 ogy and The Protein Society. held April 21-25 in Atlanta, commercial and organizational Georgia was comprised of all six booths was well received by this corporate societies and six guest international audience. The societies-the Biomedical En­ Congress boasted the largest gineering Society, Society for Ex­ poster board session managed by perimental Biology and Medi­ OSMC with over 2,500 faces CONFERENCE CENTER cine, Clinical Immunology used. OSMC has contracted to Society, Society for Mucosal Im­ provide meeting and exposition The FASEB Conference munology, American Association services for the V International Center includes the Chen Au­ of Veterinary Immunologists and Conference on Lyme Borreliosis ditorium and seven meeting the International Society for to be held in May 1992. rooms located on the Beaumont Bioelectricity. The meeting was The OSM C also provided the Campus. The Conference Center well attended with a scientific logistical planning and on-site hosted 408 meetings, 213 meals, registration of 13,587. There management of the ASBMB Fall 19 receptions and 144 program were 922 exhibit booths making Symposium held in Keystone, activities for a total of 784 func­ this the largest exposition at a Colorado in October and logisti­ tions. FASEB and the member FASEB Annual Meeting. cal planning for the APS Con­ societies scheduled 491 of these In addition to the FASEB ference "From Channels to Cross functions, with 275 sponsored by Meeting, OSMC provided meet­ Bridges" held in Bar Harbor, tenant societies and 18 from off­ ing and exhibit management in Maine in July. campus organizations. 1991 for the American Physiolog­ ical Society, the American Soci­ ety for Pharmacology and Ex­ perimental Therapeutics, the Biophysical Society and, for the Meetings Managed by the Office of Scientific Meetings first time, meeting management for the American Society for FASEB ASPET ASCB April 21-25 August 16- 20 December 8- 12 Cell Biology. Each meeting was Washington , DC San Diego, CA Boston, MA highly successful. Statistics for these meetings are shown below Scientific registration 13,587 1,04 1 7,204 Total regi~tration 18,257 1, 110 10,176 in Table 1. Programmed abstracts 8,2 15 518 2,803 The Office of Scientific Meet­ Exh ibit booths 922 497 ings and Conferences, known for BIOPH YSICAL its expertise in the management APS SOCIETY I(HG Sept. 29 ­0CL 3 February 24-28 October 6- 1 I of international congresses, was San Anto nio , TX San Francisco, CA Washington, DC responsible for the logistiCS for the 8th International Congress Scientific regiSlration 907 3,463 5,446 Total registration 947 3,884 6,141 of Human Genetics held Oc­ Programmed abstracts 576 2,306 2,883 tober 6-11 in Washington, D.C. Exhibit booths 14 98 153 The total scientific registration Table 1 was 5,446 with forty-six coun­

22 SUMMER RESEARCH CONFERENCES

The tenth annual series of 1992 CONFERENCE SCHEDULE FASEB Summer Research Con­ ferences was held at the Ver­ Vrnnunt Coppa- MouQC.tin Snowman JWIt' 1- 12 Protein foIdulg alrd A)SCnloly irl mont Academy, Saxtons River, thr- CrJj Jun~ [+-19 Recinoids Tro.nKrlpli ol);u J~ «"su latj()n: Vermont and at Copper Moun­ Diffcre-nll:ttir"I, Ot",..!opmrIU o\nd DiR'iilY: tain, Colorado. The series was June: 21 -26 Biology, ChtmlJ.try .. nd Muddling MictoliutrilC!nl" fn"J(e Y..1f"IIIt'nu composed of 18 conferences. In of V;'Sion: Violu,,1 Proco;5 i n~ Jun~ 18-Jul), ] R~ iIIl i-I C'moo>'na.mics: Intnudioru NellrQblolo~"Y ofCenl r'a.J NcrvO\ l1t wilh Enckuhdi.J and Ep llhdial S'YII~m Injury Vermont, ten conferences con­ SYJlnm. vened from June 9 through J ul, ~-1lI CaJc.ium lind Cell Function Mol«ul.n 8.uis. of M u('"(~aJ 'r.~1 (.; hm rrll'!10QH'! Strut lun:. Rep!! ­ Dl"fc.nsc uukm Ilntt St;gf~~i"lon

August 16. The Colorado series July 1 ~-17 PhQ'PhD li pa.s~ ~a=plOn .mcl Srt:TI:l 1 Tr;1n)(iI,ln lcr n HC: P)l. lic R('gtm.'rfl1u1n OIIruJ C an IflO· ~C tl r:9 1 . : Mnlr'tul:lr anit C ~II I Jl tlr of eight conferences opened on ' lo l'hw'I~·s July 19- 24 V ll:t.l'llir'l C Ju uj Vh;tnlln Rill Free Prnl(':in Phosphatuo June 23 and met through August l<:vhcul Kelu:uonJ ]6. This year there were seven July 26- 31 Virill A$sclObly Ph y~iD!OSY and P'-dth oph)'3itllu,,), of Ih~ Spham:hmc Cirru liltu;m new topics added to the series: Au'{\UI 2· 7 "·olic I\c.id. V itnmirl "It ond One Regulauon of Enc:: rl!tY a.b.ner'; Camo.n M(tabollJ.1n from Urgam.u n 10 G~n," Transgenic Animals, Positive Augusl 9· 14 Thrombin ~truC(urt: Imo r:l)nt;tion Plil l1t Molecular C~n<=l i C3 Control oj Transcription Initia­ tion in Prokaryotes, Low Molec­ ular Weight GTP Binding Pro­ teins, Modulation oj Wound Healing, Chromatin and Tran­ scription, Neurotransmitters and Modulators in Opioid Analgesia and Cytokines and Lipid Media­ tors as Regulators oj Cell Function. Once again there was an in­ crease in outside funding over the previous year. A 4.0 % in­ crease resulted in a total average of $28,551 per conference, making it the best funded year thus far in the Summer Research Conference series. Attendance ranged between 60 and 162 par­ ticipants, with an average atten­ dance of 123 per conference, which matched that of 1990. Evaluation questionnaires re­ vealed that 1991 was again rated better in many categories than in any previous year. A FASEB Annual Meeting Exhibit Hall

23 Lewis I. Gidez n 1990, the Federation Board FASEB Journal. The "50 Years Director I voted that member subscrip­ Ago" series began in the April tions to The FASEB Journal (FJ) issue. These are articles in which would become voluntary in scientists recall scientific events 1992. Members would no longer associated with FASEB 50 years receive the Journal automati­ ago. Thematic issues, introduced cally, but would be able to pur­ in 1990 with a publication pat­ chase subscriptions at a dis­ tern of a basic research theme in counted price. January and a clinical theme in Implementation of that deci­ July, continued in 1991. The­ sion began in 1991 with the for­ matic issues in 1991 were The mulation of budgeting and mar­ Human Genome Initiative and keting strategies that would AIDS-Ten Years Later. Themes enable the Journal to be pub­ for 1992 are Cytochrome P450­ lished on a self-sustaining basis. Advances and Prospects and The member subscription rate Molecular Biology-1mpact on was set at $39, and the esti­ Human Disease. The themes for mated number of member sub­ 1993 will be The New Age of scribers who would subscribe at RNA and Tumor Suppressor that price was at 2,700 (about Genes. Original Research Com­ 10 % of the total member circu­ munications are solicited for the lation for 1991). The Marketing respective themes, and these ar­ Department initiated an exten­ ticles receive the same thorough sive campaign to inform Society peer-review as all other papers members of the new policy and submitted to the Journal. to solicit renewals of their FJ Although FJ publishes scien­ subscriptions. This included sub­ tific articles in several formats, scription information on dues state-of-the-art Review articles notices of some Societies and/or continue to be the mainstay of letters from Societies to their each issue. Their number has in­ members. There were also two creased over the past 4 years. mailings of subscription notices Fig. 1 shows the number of and announcements in FJ. As of reviews and research communi­ the publication of this Annual cations published in each of the Report, 5,589 members have past 4 years. subscribed. The voluntary sub­ The ratio of Review pages to scription to FJ by so many Research Communication pages members cari be attributed to was 1.3 in 1988, and this in­ the high degree of editorial ex­ creased to 2.7 in 1991. Each is­ cellence that has been main­ sue of FJ now features 10 tained since the first issue in Review articles. Reviews, July 1987. The Journal is recog­ Research Communications, and nized as an important tool for other scientific articles com­ life science researchers and edu­ prised 74 0/0 of total pages pub­ cators. lished in 1991. The year 1991 saw the further A quantitative measure of evolution and maturing of The how scientific journals are

24 The Office of Publications 120 (OP) performs redactory and 100 publication management services for outside organizations. In 80 1991 OP published "New ~ .D Horizons in Molecular Toxicol­ E 60 :J ogy," proceedings of a sympo­ Z 40 sium sponsored by The Toxicol­ ogy Division of Lilly Research 20 Laboratories, on behalf of Eli Lilly and Company. Also in 0 1991, the Society for Leukocyte 1988 1989 1990 1991 Biology contracted with FASEB 51 64 66 63 73 73 110 50 to manage the publication of the Journal oj Leukocyte Biology, a _ Reviews c::::::::J Res. Comm. monthly publication that deals with the cellular and molecular Figure 1 biology of granulocytes, mono­ nuclear phagocytes, and lym­ phocytes. Finally, 1991 marked regarded is the Impact Factor, a AIN, AAI, and ASCB, an in­ the 20th year that the Journal oj ratio of the number of citations crease of 1,031 listings. The Bio­ Lipid Research has been pub­ in a given year (e.g., 1990) to ar­ physical Society recently joined lished at FASEB. ticles (not abstracts) published in the Federation, and members of the 2 previous years (1989 and this Society will be in the next 1988) . These factors are calcu­ Directory. lated and published by the Insti­ In conjunction with the 1990 tute for Scientific Information in FASEB meeting, programs and its Science Citation Index. The Abstract issues of FJ were pub­ Impact Factors for 1990 and lished. For the six-Society meet­ overall ranking (among 4,340 ing in Atlanta, 8,191 abstracts journals covering all branches of were programmed and published science) of the highest-ranked in three Abstract issues. The general journals that publish Office of Publications also as­ biological reviews and research sisted ASCB in the publication communications are shown in of their annual meeting program Table 1. As seen from these and abstracts. data, The FASEB Journal is in the top 1% of the 4,340 journals for which Impact Factors have Im pact Factor O vera ll Ranking been determined. Cell 26 .42 4 Another charge to the Office SCIence 19.64 11 Nature !London; 19.09 12 of Publications is the FASEB The FA5[B Journal 10.42 32 Directory of Members. The 1991-92 Directory listed 32,590 Table 1 unduplicated names of scientists in APS, ASBMB, ASPET, AAP ,

25 Thomas L. Trudeau n August the Office of Place­ major elements: Director I ment Services was established 1. Employment Opportunities as a department reporting to the section of The FASEB Executive Director, and replaced Journal. the Placement Service which a. Display and line adver­ had operated as an element of tisements are published the Office of Personnel Services. under a Positions Avail­ The Federation operates able heading. Rates are placement services year-round substantially lower than and at selected meetings, match­ charged by other na­ ing candidates seeking postdoc­ tional/international pub­ toral training and permanent lications directed at the positions with recruiting em­ audience of life sciences ployers from academia, govern­ researchers and teachers. ment and industry. Most candi­ Space reservations are dates are at the doctoral level or never required. graduate students anticipating b. Candidates, as part of conferral of the doctorate in life their registration with science disciplines. Membership the service, can compose in a society of the Federation is a five line advertisement not a prerequisite for participa­ of their availability; ap­ tion, either as a candidate or as proximately 75 % do so. an employer. Individuals not A code number is as­ holding or expecting a doctorate Signed to each advertise­ are not excluded from participa­ ment, so that interested tion as candidates. employer readers must For the purpose of establish­ contact the Placement ing employer registration fees, Service and pay a small employer organizations are fee to identify the adver­ categorized as either commercial tiser. or academic/other nonprofit 2. Referral of registered candi­ (other nonprofit consisting prin­ dates to principal employers cipally of federal government throughout the year. entities: National Institutes of a. All candidates whose Health, Food and Drug Admin­ availability is determined istration, Environmental Protec­ to be current as of mid­ tion Agency, Department of February of each year Agriculture, Department of are identified in a bound Veterans Affairs). Distribution of collection, Candidates, employer organizations by cate­ which is provided to gory: 20 % are commercial, and each registering em­ are major pharmaceutical manu­ ployer. Number of candi­ facturers and biotechnology dates included in 1991: companies; 70 % are from aca­ 353. deme; 10 % are from government b. Requests from employers agencies. for identification of can­ The service consists of three didates advertising in

26 The FASEB Journal are answered by same-day placement Service Activities at 1991 Annual Meetings mail. Referrals in 1991: Employer Position Interviews 1056. Meeting Candidates organizations t nterviewers vacancies scheduled

c. Employers telephonically FASEB 880 233 39 7 648 5,076 request file searches to April 21 - 26 select candidates meeting ASA' 531 159 212 159 4,366 specified qualifications. O ctober 26- 30 Referrals in 1991: 571. SN •• 794 237 365 426 3, 503 ovember 10-15 3. Planning and managing 2,205 629 974 1,233 12,945 interviewing operations at • American Soc iety of Anesthesiologists meetings. • * Society for Neuroscience a. Employer organizations Table 1 who choose to interview candidates at meetings are referred to as regis­ for levels of partici­ ogists and the Society for Neu­ tered employers. They re­ pation. roscience. Those services con­ ceive the bound collec­ Placement service support was sisted of planning for and tion, Candidates, referred provided to two organizations managing interviews at annual to earlier; a photocopy of outside the Federation: the meetings. See Table 1 for levels the registration of each American Society of Anesthesiol­ of participation, candidate participating in Placement Service ac­ tivities at the meeting; posting of position vacancy descriptions for review by candidates; and interview scheduling services. See Table 1 for levels of participation. b. Candidates can register with the service whether or not they attend a meeting. The registration fee, in either case, is $10 (increasing to $20 in 1992). Those who do at­ tend have the opportu­ nity to review posted position vacancy descrip­ tions; have information about availability dis­ tributed to each partici­ pating employer; and receive interview schedul­ ing services. See Table 1 Interviews in Progress at a FASEB Meeting.

27 Linda L. Acuff Director

he year was characterized Subscriptions The FASEB AdNet is ready to by unprecedented challenges launch its 1992 campaign with T 7000- ...... and opportunities for the Office seven (7) participating journals: of Marketing Services (OMS). 1000- ·· · · · · ··· ·· · · . •••• The FASEB Journal, The This report will highlight some 8000- ··· · · · · ·· · · · ···· American Journal of Clinical of the many activities under­ Nutrition, The American Jour­ taken by OMS, and will 4000-" .. nal of Pathology, The Journal describe the Department's plans 1000-· ··· 1100 of Biological Chemistry, JQurnal and goals for the coming year. 1000-'" . of Leukocyte Biology, Journal On December 4, 1991, the of Neurophysiology, and The Board of Directors officially tooo-· · · . Journal of Nutrition. Plans for designated the Office of Market­ expanding the journal base are 'II ~"'J ••tlo. """.&1 ing Services (OMS) as a Federa­ ,.....,...".. underway. FASEB AdNet is only tion department. Previously, Figure 1 one of the marketing services marketing services and promo­ that are recommended with tions were coordinated and con­ saw an average increase in each Federation proposal to ducted through a Marketing Di­ revenue from 1990 to 1991 of client societies for association vision, operating under the 32 % (see Figure II). management services. Office of Publications. The FASEB Directory of OMS will provide both Mem­ In 1992, The FASEB Journal Members is used by scientists ber and Nonmember Societies converts from a free distribution every day. From a marketing with subscription and member­ status to a paid subscription sta­ viewpoint it was beneficial to ship campaign development, tus. A major promotion focus of develop its pages to include a newsletter design, copywriting OMS was marketing subscrip­ Buyers' Product and Service and market research activities. tions to The FASEB Journal. A Guide. The Buyers' Guide ad­ In 1991 the Department was subscription campaign was vertising opportunity attracted responsible for the new image launched in July, 1991. Conser­ 82 companies and produced development of the 1990 Annual vative budgetary projections $16,200 in income. Report; update and re-design of were based on the receipt of The Marketing Department Federation Brochures; logo de­ 2,700 member subscriptions. No developed and implemented a sign and marketing strategy revenues were projected from unique concept for an advertis­ consultation to the Federation advertising. A strategic plan was ing network of biological jour­ and client Societies. These ac­ developed and implemented nals called the FASEB AdNet. tivities will continue in 1992. which resulted in 5,589 sub­ AdNet has three (3) primary ob­ The staff of OMS looks for­ scriptions at the time of this jectives: ward to contributing its exper­ report. A 107 % increase over 1. To cluster journals with tise to the missions of the new projection (see Figure I). small circulations into a Federation in the coming year. Commercial advertising pro­ network with a potential vides a substantial source of buyers base of more than revenue for publications, and 35,000. Advertising Net Revenues • tODD) helps to offset production costs. 2. To provide advertisers the ~- ...... Marketing was responsible for ability to target their ads generating advertising sales in to either a narrow or The FASEB Journal, FASEB Ex­ broad audience, while hibit Guide and FASEB Direc­ earning frequency rate dis­ tory of Members. Although counts. MI.I "' ..,... Mill...... ENr. • t .... .lhr. publications nationwide 3. To provide additional CE •••• _ •••• Figure 2 reported a downward trend in revenue for F ASEB and for 1991 sales, FASEB publications the AdNet publications.

28 Derek Knox Director

he number of personnel 1992 based on the stabilization ing serviced for comparably T who were on the staffs of of premium rates for one health sized entities which would call all the Societies in residence on plan and the lowering of pre­ for a staff of four people to the Beaumont Campus in 1991 mium rates for another. service 250 employees. The na­ are listed on the schedule below While the national unemploy­ tional per employee cost of pro­ which also shows the staffing ment rate increased considerably viding personnel services in 1991 for the previous four years. this past year, the Montgomery was $1,163 per year while the The past year was one of con­ County, Maryland figures re­ Federation's Personnel Services iderable activity and transition mained among the lowest at Department per employee cost for the Personnel Services De­ 3.2 % perpetuating a competitive in 1991 came to $792.78 per partment. As a result of a survey recruitment market in this area. year. Finally, the national me­ of Federation and Society em­ Fortunately, the turnover rate dian PersonnellHR budget as a ployees, a change from a was one of the lowest in years percentage of company costs is monthly to a semi-monthly pay­ (58 % of the previous year's 3.3 % as compared to a FASEB roll system was introduced and figure) with a total of 37 em­ 1991 budgeted figure of 2.1 % . has since proven to be extremely ployees hired as a result of ap­ popular. Concurrently, a simpli­ proximately 160 interviews. ned time and fund allocation The Personnel Services reporting system was initiated Department staff went from a ulting in considerable reduc­ staff of three full-time employees n in amount of paper work to two and one-half FTE pro­ r both employees and the ducing a ratio of 1.0 persons per ral Accounting Services 100 employees being serviced. artment. This compares to a national me­ This was also the completion dian ratio of 1.6 personnel staff of the initial year of the IRS members per 100 employees be­ Section 125 Flexible Spending Account Program whereby pay­ ments toward health insurance Number of Regular Employees on the Payroll premiums and health and de­ as of December 31 pendent care could be made on a tax-free basis. In addition to 1987 1988 1969 1990 1991 reducing the taxable income of FASEB 104 132· 132' 125" 128'" the majority of employees who APS 47 39 41 43 45 ASBMB 18 19 18 III 17 elected to participate, the Sec­ ASPET 5 4 4 4 5 tion 125 Plan resulted in em­ AAP 9 2 4 4 4 AIN 13 5 5 7 G ployer savings equal to 11 % of AAIIJI 8 9 TO 10 11 ASeB 8 9 11 12 11 the cost of health insurance - - - premiums. Meanwhile, the Fed­ Total 212 2 19 226 223 228 (FASEB & Societies) eration's managed health care TE'nant, (n on-payroll) 61 52 54 53 48 program (which includes an - Total 274 271 280 276 276 Employee Assistance Program) (Pay roll & Tenant~) kept the increase in the cost of Include, 30 employees leased to non-member societies . providing medical care and ser­ H Includes 31 cmrloyees it!ased to non-member societies. vices to 5.7% while the national 'H Includes 35 employees leased to non-member societies. cost rose by close to 8 %. Dra­ Table 1 matic savings are anticipated for

29 Kenneth D. Fisher Director

ince 1962, the mission of the transferred to LSRO in 1991. the impact of nonresponse on SLife Sciences Research Office Federation archives were trans­ dietary data from the 1987-1988 (LSRO) has been to marshal the ferred to the Executive Director's Nationwide Food Consumption expertise of the members of the office and the interlibrary loan Survey for the Human Nutrition Constituent Societies in address­ activities were terminated. The Information Service, U.S. De­ ing issues related to research BIRC is maintaining a core set partment of Agriculture. The topics in the biomedical sciences. of current publication resources Expert Panel concluded that the In carrying out this mandate, and bibliographic and biograph­ dietary data should be used only LSRO utilizes the expertise of ical data reference sources; a with considerable caution. A the Society Members and other limited set of general references fourth Expert Panel completed qualified scientists for analysis in biomedical disciplines, various its evaluation of the safety of and assessment of specific topics organizations and individual caprenin, a new reduced-calorie in biology and medicine; pro­ directories; and access to hold­ fat developed by The Procter & vides expert scientific evaluation ings of the National Library of Gamble Company. of research proposals, programs, Medicine via MEDLINE A workshop on "Development and issues in the life sciences; services. of Medical Foods for Rare Dis­ and disseminates pertinent scien­ eases" was held in June. Spon­ tific reviews and reports of the sored by the National Institute Scientific Review Studies and LSRO to the scientific commu­ of Child Health and Human Workshops nity and the public. Development, the National Insti­ In 1991, the Board expanded In 1991, LSRO completed 16 tute of Diabetes and Digestive the scope of LSRO as the scien­ reports, initiated two projects, and Kidney Diseases, the Office tific and technical resource of and continued efforts on two of Orphan Products Develop­ the Federation to include en­ projects. In addition, one work­ ment of the Food and Drug Ad­ hancing minority participation shop was held. ministration, the International in research and maintaining LSRO Expert Panels com­ Life Sciences Institute, the U.S. scientific information resources pleted two reports for the Nutritional Group of Bristol­ for use by Constituent Society Center for Food Safety and Ap­ Myers Squibb, and the National offices, Federation staff, and plied Nutrition, Food and Drug Biscuit Company, the workshop other Beaumont Campus occu­ Administration: "Emerging Is­ focused on developing new ap­ pants. In early 1991 LSRO as­ sues in Food Safety and Quality proaches to and coordination of sumed responsibility for the for the Next Decade" and efforts between biomedical ex­ Visiting Scientists for Minority "Guidelines for the Assessment tramural funding agencies and Institutions Program and the and Management of Iron Defi­ the various governmental, aca­ Beaumont Information Resource ciency in Women of Childbear­ demic, and clinical disciplines Center (BIRC) , which replaced ing Years." The former identifies that are involved in the develop­ the FASEB Library. topics requiring both research ment of medical foods. The and regulatory attention of workshop report includes recom­ FDA, including issues associated mendations on research needs Beaumont Information Resource with microbiolOgical safety, im­ related to medical foods for rare Center (BIRC) pacts of biotechnology, and ef­ and orphan diseases including Based on a review and evalua­ fects of the internationalization those resulting from inborn er­ tion of the need for scientific in­ of the food industry. The latter rors of metabolism. formation resources of the Beau­ report addresses prevalence, risk mont Campus by the Executive factors, detection, and treatment Officers Advisory Committee, re­ of iron deficiency. sponsibility for the BIRC was Another Expert Panel analyzed

30 Scientific Evaluations panels, conduct peer-reviews of lege (TN), and Xavier University research proposals, evaluate The major effort of LSRO in (LA) attended, presented papers research programs, and make and posters and participated in 1991 was the preparation of 12 recommendations on research programs in their respective dis­ monographs that evaluated pub­ needs and opportunities for ciplinary interests. In conjunc­ licly available scientific evi­ various Federal agencies and tion with NIGMS, LSRO spon­ dence on certain nutrient-disease organizations in the private sored a symposium on the relationships. Twelve authors sector. MARC programs. Federation and 37 reviewers assisted LSRO President R. Cousins was the in completion of these mono­ keynote speaker. graphs in an 8-month period. Based on the success of the The evaluations were conducted Visiting Scientists For Visiting Scientist Program, the for the Center for Food Safety Minority Institutions Federation was awarded a new and Applied Nutrition, FDA, in 3-year grant by NIGMS. The connection with its development In 1991, the Visiting Scientists 1992- 1994 MARC grant includes f proposals for health claims on for Minority Institutions Pro­ expansion of the Visiting Scien­ foods as mandated by the Nutri­ gram completed its 10th year in tist Program, continuation of the tional, Labeling and Education a highly successful and innova­ Scholarship Award program for :\ct of 1990. tive program. Funded by the attendance at a Federation­ In connection with work for Minority Access to Research sponsored national meeting, and the Office of Naval Research, Careers (MARC) Programs and a Summer Research Conference hree workshops were held. managed by the National Insti­ Scholarship Award program. :\inety-eight investigators, in­ tutes for General Medical Sci­ This new activity will provide cluding many ASBMB and ences (NIGMS), this program an opportunity for 36 faculty at :\SCB members, met to review receives multi-institute support. minority institutions to attend research progress on the ONR The Visiting Scientists Program one of the Summer Research \Iolecular Biology Program's provides opportunities for educa­ Conferences. research initiatives on molecular tion and research at minority recognition, biocorrosion, and colleges and universities by inter­ Advisory Committee metal-ion biosensors. Each group action with distinguished investi­ developed recommendations to gators in the biomedical sci­ Activities of LSRO are guided ONR on research opportunities ences. In 1991, 40 members of by the Federation's LSRO Advi­ and evolving research thrusts. In the Constituent Societies spent sory Committee. All scientific addition, site visits as well as more than 130 days at 38 minor­ reports completed and actions research proposal and program ity institutions presenting lec­ proposed by LSRO are reviewed reviews were conducted for tures, demonstrations, seminars, and approved by the LSRO Ad­ ONR's program on medical uses counseling students, and assist­ visory Committee. LSRO main­ of free-electron lasers. ing faculty in the conduct of re­ tains close liaison with the Ex­ Overall, 78 members of the search and curriculum im­ ecutive Officers of Constituent Constituent Societies assisted provement. Societies and the Office of Pub­ LSRO in 1991 in its efforts to In 1991, the program was ex­ lic Affairs, as well as other provide scientific advice and panded to include Scholarship scientific societies, and officials counsel on the several review Awards to five minority institu­ of Federal and private agencies. and evaluation studies. Members tions for attendance of faculty These efforts enhance the oppor­ of the Constituent Societies that and students at the Federation tunity for Federation scientists to served on panels, reviewed meeting in Atlanta, GA, on contribute their knowledge and reports, and provided informa­ April 21-25. One faculty mem­ expertise to important issues in tion, views, and data are listed ber and two students from Cen­ biological, medical, and public on the left. As consultants and tral State University (OH), health research through the ac­ reviewers for LSRO, Society Florida International University tivities of LSRO. members and other research (FL), Grambling State Univer­ investigators serve on expert sity (LA) , Meharry Medical Col­

31 1991 LSRO Review & Evaluation Panel Participants

The American Physiological Society Howerde E. Sauberlich (AIN [ASCN]) M. Eric Gershwin (ASCN, AAI) University of Alabama at Birmingham University of California, Davis Claude D. Arnaud, Jr. (ASBMB, ASCB) University of California, San Francisco Peter G. Sch ul tz University of California, Berkeley Scott M. Grundy (ASCN) Saul W. Brusilow University of Texas Southwestern Medical Johns Hopkins University School of Medicine Karl David Straub Center John L. McClellen VA Hospital George F. Cahill, Jr. Robert P. Heaney (ASCN) Consultant Richard B. Thompson Creighton University University of Maryland School of Medicine Richard J. Havel (AIN [ASCN)) Clement Ip University of California School of Medicine David C. White Roswell Park Memorial Institute University of Tennessee Richard C. Moon Kimberly Kline (AAI) Illinois Institute of Technology Research American Society for Pharmacology University of Texas Institute and Experimental Therapeutics Robert H. Knopp (ASCN) Robert D. Steele (ASBMB, AIN) University of Washington School of Medicine University of Wisconsin Joseph F. Borzelleca Medical College of Virginia Theodore Kotchen (ASCN) Louis Tobian, Jr. University of West Virginia School of Howard R. Knapp University of Minnesota Hospital and School University of Iowa College of Medicine Medicine of Medicine Theodore P. Labuza Patrick Tso Timothy J. Maher Massachusetts College of Pharmacology University of Minnesota Louisiana State University Medical Center James E. Leklem (ASCN) Mackenzie Walser (ASCN) Lawrence G. Raisz University of Connecticut Health Center Oregon State University The Johns Hopkins University School of Kristen W. McNutt Medicine David K. Rassin (AIN [ASCN)) University of Texas Medical Branch Consumer Choices, Inc. Elaine R. Monsen (ASCN) American Association of Pathologists University of Washington American Society for Biochemistry and Molecular Biology Francis S. Ligler (AAI) Ronald L. Prior Naval Research Laboratory U.S. Department of Agriculture, Agricultural Alvito P. Alvares (ASPET) Research Service, Human Nutrition Uniformed Services University of Health Adrianne E. Rogers (AIN) Research Center Sciences Boston University School of Medicine George F. Stevenson Daphne A. Roe (ASCN) Stephen J. Benkovic Cornell University The Pennsylvania State University American Society of Clinical PatholOgists A. Catharine Ross (ASCB) Kenneth K. Carroll (AIN [ASCN)) American Institute of Nutrition Medical College of Pennsylvania University of Western Ontario Phyllis Acosta (ASCN) F. Edward Scarborough (ASCN) Louis J. Elsas II Food and Drug Administration Emory University Ross Laboratories Lynn B. Bailey (ASCN) Barry Honig Mary K. Schmidl University of Florida Columbia University Sandoz Nutrition Technical Center William R. Beisel (ASCN) Barbara O. Schneeman (APS) James T. Kellis, Jr. Johns Hopkins School of Hygiene and Public University of California, Irvine Health University of California, Davis Norman Kretchmer (AIN [ASCN)) Ching K. Chow (ASCN) Jon A. Story University of California, Berkeley University of Kentucky Purdue University David Kritchevsky (AIN [ASCN)) Fergus M. Clydesdale Steven R. Tannenbaum Wistar Institute University of Massachusetts Massachusetts Institute of Technology Carlos L. Krumdieck (AIN [ASCN)) William E. Connor (ASCN) Daniel Rudman (ASCN) University of Alabama Oregon Health Sciences University VA Medical Center I. D. Kuntz James D. Cook (ASCN) Myron H. Weinberger (ASCN) University of California, Kansas University Medical Center Indiana University School of Medicine San Francisco Stephen C. Cunnane Ray Yip Robert F. Labbe (AIN [ASCN)) University of Toronto Centers for Disease Con trol University of Washington School of Medicine Peter R. Dallman (ASCN) University of California, Burt N. La Du, Jr. (ASPET) The American Association of University of Michigan Medical School San Francisco Immunologists Joachim G. Liehr (ASPET) Philip M. Farrell (ASCN) Listed previously University of Texas Medical Branch University of Wisconsin Michael T. Marron Elaine B. Feldman (ASCN) Office of Naval Research Medical College of Georgia American Society for Cell Biology Robert W. Newburgh Owen Fennema Michael W. Berns Office of Naval Research University of Wisconsin Beckman Laser Institute and Medical Clinic Thomas V. O'Halloran Allan L. Forbes (ASCN) Stan Ivey Northwestern University Consultant Delaware State College Alexander Rich Pamela J. Fraker (AAI) Joseph G. Szekely Massachusetts Institute of Technology Michigan State University Atomic Energy of Canada, Ltd.

32 1991 MARC PROGRAM

Visiting Scien tists Institution Visited The American Physiological Society W. R. Dukelow, Mi chigan State University University of Texas, Pan American W. R. Dukelow, Michigan State University Jackson State College P. Fail, Research Triangle Institute Florida International University '.'1. B. Frey, Lockheed Engineering & Scientific Company University of the Virgin Islands '.1. S. Gordon, University of California, Los Angeles University of Guam P. J. Gunter-Smith, National Naval Medical Center Spelman College Lal Harbans, Elizabeth City State University J. A. Holloway, Howard University Tuskegee University J. A. Holloway, Howard University Lane College/Tennessee S. Price, Medical College of Virginia Selma University C. O. Trouth, Howard University College of Medicine Central State University

American Society jor Biochemistry and MoleClilar Biology A. P. Alvares, Uniformed Services Univ. Sch. of Med. New Mexico Highlands University (ASPET) Pembroke State University/NC C . 1\1. Carlson. Univ. of Tennessee College of Medicine Prairie View A&M University .I . H. Cherry, Auburn University Delaware State College T. '.'1. Chu, Roswell Park Memorial Institute (AAP, AAI) Catholic University of Puerto Rico n. c. Fuller, University of Massachusetts Meharry Medical College B. P. Gaber, Naval Research Laboratory Morris Brown College F. D. Hamilton, Florida A&M University Delaware State College C. B. Kohlhaw. Purdue University Tuskegee University J. A. Last, University of California, Davis University of the Virgin Islands H. M. Lenhoff, University of California, Irvine (ASCB) Meharry Medical College J. P. Liberti, Virginia Commonwealth University New Mexico Highlands University R. O. Morris, University of Missouri Southern University S. N. Pennington, East Carolina University University of Puerto Rico I). J. Roufa, Kansas State University Clark Atlanta University n. B. Sanders, University of Kansas (ASPET) Meharry Medical College D. Silver, University of Illinois College of Medicine University of Alaska J. J. Villafranca, Pennsylvania State University

American Society jor Pharmacology Gild Experimental Therapeutics University of Southern Colorado R. P. Maickel, Purdue University

Aml'J'ican Association oj Pathologists University of Alaska D. P. Perl, Mount Sinai School of Medicine University of Houston, Downtown H. Rothschild, Louisiana State University Medical Center

American institute oj Nutrition Xavier University of Louisiana '.1. L. Failla, University of North Carolina, Greensboro Selma University D. S. Sachan, University of Tennessee Tennessee State University D. S. Sachan, University of Tennessee

The American Associatio'l oj immunologists Inter American University. E. Fowler, CIBA-Geigy Agriculture (ASCB) Puerto Rico J. '.-1. Mansfield, University of Wisconsin University of Puerto Rico D. M. Paulnock, University of Wisconsin University of Puerto Rico

The American Society jor Cell Biology E. Fowler, CIBA-Geigy Agriculture (AAI) Savannah State University C. Impraim, Life Technology Inc. Florida A&M University r. L. Jordan, Ohio State University College of Dentistry Tennessee State University F. L. Jordan, Ohio State University College of Dentistry SUNY/College at Old Westbury W. E. Thomas, Ohio State University College of Dentistry Virginia Union University D. J. Wilson, Meharry Medical College Tennessee State University D. J. Wilson, Meharry Medical College Elizabeth City State University D. J. Wilson, Meharry Medical College Baruch College D. J. Wilson, Meharry Medical College Fisk University

33 ederation facilities, collec­ The Gorgas Memorial Institute on the electrical power supply to F tively known as the Beau­ The International Institute for attenuate power surges that have mont Campus, comprise more Vital Registration and plagued Campus facilities for than 120,000 square feet of Statistics several years, installation of an office, conference and storage The Journal of American Society uninterruptable power supply to accommodations, set in approxi­ for Hematology/Blood maintain telephone service dur­ mately twelve acres of attrac­ The Undersea and Hyperbaric ing power outages, lighting reno­ tively landscaped grounds. The Medical Society vation and interior and exterior facilities provide an exceptionally painting. In addition, the de­ pleasant environment for the Systems support for Campus partment facilitated the transfer Federation and Society staffs, residents is provided by a group of nearly 15 percent of the office and include conference facilities of departments collectively accommodation formerly as­ that are frequently used for known as the Production Ser­ Signed to Federation functions, meetings of Society councils and vices Departments. Administra­ to the Societies. committees. tion of these departments was In addition to Federation and reorganized during 1991, and Member Societies, facilities are they now report directly to the Printing and Graphics Services made available to non-member Executive Office. provides prepress, printing and organizations in the area of ex­ bindery for stationery, newslet­ perimental biology on a space­ ters, brochures, reports and available basis. During the year, Buildings and Grounds has typesetting services. The depart­ the non-member organizations the responsibility for facilities ment had a very productive accommodated in the facilities maintenance and renovation. In year, achieving almost a 6 per­ included: addition to routine maintenance cent growth in activities over activities, the staff of this 1990. This performance is The Agricultural Research department completed several remarkable in comparison with Institute major projects. Some included commercial vendors in this area The American Association for installation of protection systems who report a 9 percent decrease Accreditation of Laboratory Animal Care The American Board for Medical Genetics The American College of Toxicology and Teratology The American Medical Writers Association The American Society for Animal Science The American Society for Human Genetics The Association for Research in Vision and Ophthalmology The Council of Biology Editors The Ecological Society of America The Endocrine Society From left to right: Debbie Stoutamire, Coordinator; Production The Genetics Society of America Service Managers: Rick Dunn, Gil Moore, Randy Smisek.

34 in activities for the comparable period. The department management has invested substantial time in planning modifications in procedures and processes to improve cost-effectiveness and quality of operations and streamline production. The benefits of these plans will become evident in 1992. The department conducted a user sur­ vey, which indicated a high level of appreciation of the services provides, and several suggestions for improvement that were incorporated in the planning process.

Data Processing Staff: (Back L-R) Mike Quinn, Gil Moore, Mgr. , Anil Ganio, (Front L-R) Ed Marklin, Kim Kline, Diane Way.

Mailing and Addressing Services provide an in­ terface between the Campus community and the U.S. Postal Service and private couriers. The service provides twice-daily delivery and pickup of mail from all Campus offices and ensures ex­ peditious disposition. During the course of the year, mOre than 1.5 million pieces of outgoing mail were prepared and distributed by the department, an increase of nearly 6 percent over the preceding year.

Prillting and Graphics Services: Rita Pumphrey and Don The Purchasing Office maintains an inventory dc Wall checking a p1'ess sheet. of commonly used office supplies, which can be supplied to Campus residents at a significant dis­ count due to the volume of procurement. In ad­ dition, the office facilitates procurements with Data Processing Services provides a wide range local vendors. of support systems for all aspects of Society management activities. In addition to develop­ ment and maintenance of membership databases, the department supports abstract processing and program development for meetings management, and journal publication management services in­ cluding manuscript tracking and subscription ful­ fillment. New facilities developed during the year include automatic spell checking for abstract titles, a system for modeling the national biomed­ ical research budget, system independent auto­ matic word wrap capabilities for database management, and a "windows" package for con­ current maintenance of multiple file systems. During the year the department undertook major upgrades to the system hardware, including in­ stallation of a 486, 33-MHz processor, increased data storage capability, and installation of addi­ Mailing and Addressing Staff: (L-R) Robert Johnson, William tional access ports. Sakowski, Erik Fuss , Richard Bennett,

35 The finances of the Federation for calendar year 1991 are detailed in the finan­ cial schedules that follow. These schedules summarize the more detailed finan­ cial statements audited by Arthur Andersen & Co., a leading national account­ ing and consulting firm. A copy of the audited financial statements is available from the Comptroller's Office.

Balance Sheet The balance sheet presents the Assets, Liabilities, and Fund Balance of the Federation on December 31, 1991. There is a very healthy 3.06 to 1 ratio be­ tween assets ($13,665,541) and liabilities ($4,471,233). The Fund Balance (or net worth of the Federation), i.e., the difference between assets and liabilities, is $9,194,308 which is the accumulated total of net operating results over the or­ John R. Rice ganization's 78-year hisotry. Comptroller Current assets of the Federation include cash, receivables, supplies, and fu­ ture year's expenses prepaid in 1991, which total $1 ,926,066. Investments of $6,731,226 are placed primarily in U.S . Treasury bills and notes, commercial paper, and commercial bonds. The earnings on these investments float with changes in the prime interest rate and act as a hedge against the interest rate payable on the Economic Development Revenue Bond loan, which financed new construction in 1984-86. The interest rate on the mortgage also floats with the prime. A portion of the Capital Fund, Depreciation Funded Reserve and De­ velopment Fund is invested in stocks and long-term bonds as authorized by the Federation Board. A most significant asset is the net investment of $5,008,249 in the buildings, grounds, furniture, and equipment on the Beaumont campus, which provides a home for the Federation, its constituent Societies, and 25 other scientific and educational Societies whose offices are on the campus. Liabilities totaling $4,471,233 include amounts owed to vendors on Decem­ ber 31, 1991 for products and services received ($126,910), revenue received in 1991 but applicable to programs to be conducted in 1992 ($1,285,001); amounts owed to employees under deferred compensation plans ($591,692); annual leave accruals ($215,319), and the note payable to Maryland National Bank in con­ nection with the Economic Development Revenue Bond ($2,252,311). The Fund Balance of the Federation ($9,194,308) increased by $818,715 in 1991 as a result of net dividends, interest and net capital gains on investments ($470,209) , contributions to the Development Fund ($29,175), and results of an­ nual operations ($319,331).

Statement of Revenue and Expense The statement covers the 12 months for the year ending December 31, 1991, and identifies the sources of revenue and categories of expense. The Federation Board adopted a new financial plan effective with calendar year 1991. Each fall the Board sets a fixed rate of dues to be paid to the Federa­ tion by the member Societies in the following year. At its meeting on December 2, 1990, the Federation Board set the 1991 annual dues for the six Founding Mem­ ber Societies at $40 per mem ber and for the American Society For Cell Biology, which was elected to membership on July 1, 1991 , at $10 per member ($5 per member for six months in 1991). The Biophysical Society joined the Federation on December 1, 1991 and participated as a full member in the December 4, 1991 meeting of the Federation Board. The Biophysical Society will begin pay­ ing dues at a level of $10 per member per annum in 1992. Further reductions in dues are planned each year through 1995 to a targeted level of $10 per mem­ ber, and this rate is offered to new member Societies joining the Federation be­ fore 1995. To further its scientific and educational mission and to provide as­ sistance to Societies in the biomedical sciences, the Federation has developed a wide range of supporting services in the areas of scientific meetings and con­ ferences, publications, placement services, public affairs and association management.

36 Balance Sheet December 31, 1991

Current . Restricted Assets: Fund Fund Total

Current Assets Cash and Cash Equivalents $ 396,469 $ 153,822 $ '550,291 U. S. Government Contract Receivables 244,151 244,151 SOciety and Custodial Receivables 313,787 - 313,787 Accounts Receivable-Other 471,141 103,610 574,751 Supplies and Prepaid Expenses ~1,526 1,560 243,086 1,422,923 503,143 1,926,066

Investments, at cost 6 , 71!~ 850 ~~76 6,731,226

Property and Equipment, at cost Land, Buildings and Improvements 7,155,342 7,155,342 Furniture and Equipment 2,127,055 2,127,055 9,282,397 9,282,397 Less Accumulated Depreciation (4,274,148) (4,274,148) 5,008,249 5,008,249

$13,146,022 $ 519,519 $13,665,541

Liabilities and Fund Balance:

Current Liabilities Accounts Payable and Accrued Expenses $ 117,220 $ 9,690 $ 126,910 Deferred Revenue 775,172 509,829 1,285,001 Deferred Compensation Plans 591,692 591,692 Accrued Annual Leave 215,319 215,319 Notes Payable, Maryland National Bank 116,004 116,004 1,815,407 519,519 2,334,926

Long Term Debt Notes Payable, Maryland National Bank 2,136,307 2,136,307 3,951,714 519,519 4,471,233

Fund Balance Beginning of Year 8,375,593 8,375,593 Excess of Revenue Over Expense 818,715 818,715 End of Year 9,194,308 9,194,308

$13,146,022 $ 519,519 $13,665,541

37 Statement of Revenue and Expense For The Year Ended December 31, 1991

Current Restricted Revenue: Fund Fund Total

Society Dues $ 1,117,192 $ $ 1,117,192 Exhibit Commissions 227,223 227,223 Government and Private Support 1,632,860 1,632,860 Subscriptions and Publication Sales 790,417 3,789 794,206 Advertising 284,267 72,405 356,672 Educational Exhibits 1,506,644 1,506,644 Registrations 1,075,305 3,194,020 4,269,325 Abstract Handling Fees 231,324 231,324 Conference Support and Grants 550,487 550,487 Rent 933,169 933,169 Printing, Computer & Business Services 2,242,392 2,242,392 Contributions to Development Fund 29,175 29,175 Dividends and Interest on Investments 470,209 1,455 471,664 Insurance Plans-Dividends and Allowances 47,728 47,728 Management Fees 702,648 702,648 Other Income 50,812 58,096 108,908 8,521,024 6,700,593 15,221,617

Expense: Personnel Costs 3,630,232 675,713 4,305,945 Editor-in-Chiefs Office 111,772 111,772 Contracted Services 491,997 605,327 1,097,324 Composition and Printing 605,976 431,556 1,037,532 Sales and Exhibit Commissions 13,359 238,006 251,365 Theme and Poster Sessions 186,366 186,366 Promotion and Marketing 38,609 1,780 40,389 Projection and Public Address Services 248,887 248,887 Public Information Service 50,483 50,483 Supplies and Duplicating 339,459 142,543 482,002 Communications and Shipping 400,515 184,755 585,270 Hotel and Travel 1,178,325 166,979 1,345,304 Computer Services 73,153 42,127 115,280 Rentals of Space and Equipment 32,796 830,530 863,326 Repairs and Maintenance Expense 150,595 1,888 152,483 Depreciation (Note 3) 339,696 339,696 Insurance and Taxes 120,347 13,832 134,179 Utilities 152,928 152,928 Interest Expense 169,655 169,655 Auditing and Legal Fees 34,121 310 34,431 Other Expenses and Supplies 119,715 64,049 183,764 8,003,250 3,885,131 11,888,381

Allocations: Indirect Expenses Charged to Restricted Fund (244,540) 244,540 Fixed Fees Charged To Restricted Fund (56,401) 56,401 Funds Returned to Sponsors and Reserves .2,738,968 2,738,968 Increase (Decrease) in Funds Deferred to Future Years {224,447} (224A47} 7,702,309 6,700,593· 14,402,902 Excess of Revenue Over Expense $ ·818,715 $ $ 818,715

38 Revenue and Expense By Activity and By Category For Calendar Year 1991 >, Revenue~1991 Expense-1991 By Activity Amount % By Activity Amount % Office of Publications $ 958,764 6.3 Office of Publications $ 1,210,912 8.0 Office of Scientific Meetings 651,964 4.3 Office of Scientific Meetings 477,051 3.1 Placement Service 220,220 1.4 Placement Service 182,119 1.2 Membership Directory 54,688 .4 Membership Directory 174,597 1.1 Public Affairs 83,000 .5 Public Affairs 474,439 3.1 Summer Research Conferences 1,496,880 9.8 Summer Research Conferences 1,335,677 8.8 Buildings and Grounds 777,388 5.1 Buildings and Grounds 1,174,341 7.7 Print Shop & Composition 1,026,987 6.8 Print Shop & Composition 833,863 5.5 Data Processing 559,491 3.7 Data Processing 447,559 2.9 Business Service Activities 747,502 4.9 Business Service Activities 1,018,460 6.7 Government Contracts 1,083,868 7.1 Government Contracts 815,814 5A Private Contracts 5,616,725 36.9 Private Contracts 5,583,838 36.7 General & Administrative 1,944,140 12.8 General & Administrative 674,232 4.4 Reserves 818,715 5.4 Total $15,221,617 100.0 Total $15,221,617 100.0 - ---­ By Category Society Dues $ 1,117,192 7.4 By Category Publication Sales 1,150,878 7.6 Personnel Costs $ 3,968,509 26.1 Exhibits, Registrations, Abstract Printing 1,037,532 6.8 Handling Fees-Scientific Meetings 6,007,293 39.5 Meeting & Publication Services 2,141,898 14.1 Rental Income 933,169 6.1 Consultant Fees & Stipends 272,920 1.8 Business Service Billings 2,242,392 14.7 Supplies, Mailing & Operating Expenses 1,415,214 9.3 Conference Support 550,487 3.6 Travel 1,345,304 8.8 Contracts and Grants 1,632,860 10.7 Maintenance & Buildings Expense 948,941 6.2 Management Fees and Commissions 929,871 6.1 Management Fees 758,063 5.0 Investment Income 471,664 3.1 Funds Returned to Sponsors 2,514,521 16.5 Other Income 185,811 1.2 Reserves 818,715 5.4

Total $15,221,617 100.0 Total $15,221,617 100.0

Color Keys Revenue---1991 Expense---1991 Color Keys

• Society Dues (7.4%) • Personnel Costs (26.1 %) Publications Sales (7.6%) • Printing (6.8%) o Exhibits, Registrations, Abstract Handling o Meeting & Publication Services (14.1%) Fees-Scientific Meetings (39.5%) • Consultant Fees & Stipends (1.8%) Rental Income (6.1 %) o Supplies, Mailing & o Business Service Billings (14.7%) Operating Expenses (9.3%) • Conference Support (3.6%) • Travel (8.8%) o Contracts and Grants (10.7%) o Maintenance & Buildings Expense (6.2%) o Management Fees and o Management Fees (5.0%) Commissions (6. 1%) o Fund Returned to Sponsors (16.5%) ~ • Investment Income (3.1 %) o Reserves (5.4%) • Other Income (1.2%) Public and Congressional Testimony Presented By FASEB and Member Societies

• Testimony by Dr. Thomas S. Edgington, Scripps and Cori Bargmann, Massachusetts Institute of Research Institute, for FASEB, before the House Technology, for ASCB (May 9) . Energy Committees Health and Environment sub­ • Testimony by Dr. Nichols, for AIN, before the committee hearing on indirect costs (April 16). House Agriculture Appropriations subcommittee • Testimony by Dr. Edgington for FASEB before the on FY 1992 appropriations for nutrition research at Senate Appropriations subcommittee on Labor, the USDA (May 15) . HHS, Education and related Agencies (LlHHS) • Testimony by Dr. Joe W. Grisham, University of concerning FY 1992 appropriations for the Na­ North Carolina, for FASEB, before the House tional Institutes of Health (NIH) (April 17). Also VA/HUD Appropriations subcommittee on FY testifying were Drs. Martin Frank, APS Executive 1992 appropriations for the VA, NASA and the Na­ Officer, for APS (April 17); Elliot S. Vesell, Penn­ tional Science Foundation (NSF) (May 2). Also tes­ sylvania State University College of Medicine, for tifying were Drs. Galen Toews, University of ASPET (April 17); Patricia B. Swan, Iowa State Michigan Medical Center, for AAI, and Richard University, for AIN (April 17); Richard G. Lynch, B. Marchase, University of Alabama, Birmin­ University of Iowa, for AAI (April 17); Bruce M. gham, for ASCB (May 2). Alberts, University of California, San Francisco, • Testimony submitted by Drs. Grisham, for AAP, for ASCB (April 26); and Susan A. Gerbi, Brown and Toews, for AAI, to the Senate VA/HUD Ap­ University, for ASCB, ASBMB (April 26). propriations subcommittee regarding FY 1992 • Testimony by Dr. Vesell, for ASPET, before the research funding at the VA, NASA, and NSF (May House Commerce/Justice/State Appropriations sub­ 17). committee on FY 1992 appropriations for the FBI • Testimony submitted by Dr. Burks, for ASPET, to (April 17). Vesell asked the subcommittee to urge the the Senate Labor and Human Resources Commit­ FBI to make apprehension of animal rights terrorists tee on ADAMHA reorganization (June 25). a higher priority. Testimony was submitted by Dr. • Testimony submitted by Dr. Robert J. Cousins, Thomas F. Burks, University of Texas Health Science University of Florida, for FASEB, to the House Post Center, Houston, for ASPET, to the Senate Com­ Office and Civil Service committee's Human merce/J ustice/State Appropriations subcommittee on Resources subcommittee hearing on proposed fed­ the same issue (April 17). eral employees ethics regulations. Testimony also • Testimony by Dr. Howard K. Schachman, Univer­ submitted by Dr. Frank Standaert, Toledo Hospi­ sity of California, Berkeley, for ASBMB, before the tal, for ASPET, and Dr. Michael E. Lamm, Case House Science, Space and Technology Committee's Western Reserve University, for AAP (October 22). Science subcommittee on indirect costs (April 25). • Testimony by Dr. Cousins, for FASEB, before the • Testimony by Dr. Edgington, for FASEB, before the Public Health Service's Advisory Council on Scien­ House LlHHS Appropriations subcommittee on FY tific Integrity regarding scientific misconduct in 1992 appropriations for NIH (May 9). Also testify­ Cambridge, Mass. (November .17). ing were Drs. Frank, for APS (May 13); Harold E. • Testimony by Dr. Shu Chien, University of Varmus, University of California, San Francisco, for California, San Diego, for FASEB, before an NIH ASBMB (May 9); Burks, for ASPET (May 9); Buford advisory committee on indirect costs proposals. L. Nichols, Baylor College of Medicine, Houston, Also testifying were Drs. Frank, for APS; Schach­ for AIN (May 13); Alan M. Kaplan, University of man, for ASBMB; and Grisham, for AAP (Decem­ Kentucky College of Medicine, for AAI (May 8); ber 11).

40 SPECIAL EVENTS, PUBLIC STATEMENTS AND LETTERS

January 2 ASPET letter from Dr. Burks to all members of July 29 Congressional Biomedical Research Caucus' brief­ Congress on animal facilities protection legislation. ing on Women's Health Research featuring Dr. Bernadine January 15 Congressional Biomedical Research Caucus' Healy, director of NIH. briefing titled, "Why is There No Vaccine for the AIDS Vi­ August 8 FASEB letter from Dr. Cousins to OSIR Director rus?" Speakers featured were Drs. Tom Pollard, Johns Hop­ Lyle Bivens on proposed scientific misconduct regulations. kins University, of ASBMB, ASCB and the Biophysical So­ Letters were also sent by APS from Dr. Norman C. Staub, ciety; and Malcolm Martin, National Institute of Allergy University of California, San Francisco, (August 8); and and Infectious Diseases, of ASBMB. ASPET from Dr. Standaert (August 8). March 13 Congressional Biomedical Research Caucus· brief­ September 12 ASBMB letter from Dr. Schachman to OSIR ing titled, "The Cloning of the Cystic Fibrosis Gene: An Director Lyle Bivens on scientific misconduct. American Biomedical Research Success Story." Speakers fea­ September 15 ASPET letter from Dr. Standaert to Califor­ tured were Dr. William Brinkley, Baylor College of Medi­ nia Governor Pete \,yilson urging veto of animal testing ban cine, of ASCB. legislation. March 15 ASBMB letter from Dr. Schachman to NSF In­ September 19 ASPET letter from Dr. Standaert to Congress­ spector General Linda G. Sundro on scientific misconduct man Henry Waxman in support of ADAMHA reorganiza­ costs. tion legislation. March 28 FASEB Consensus Conference issued a report on September 20 FASEB letter from Dr. Cousins to Office of FY 1992 Research Funding from Dr. Edgington to Congress Government Ethics (OGE) administrator Leslie Wilcox on and key administration officials. proposed federal employee ethics regulations. Letters were May 20 Congressional Biomedical Research Caucus' brief­ also sent from APS by Dr. Frank (September 16) , ASPET ing titled "From Bench to Bedside: The Biotechnology Revo­ by Dr. Standaert (September 20), and AAP by Dr. Lamm lution." Speakers featured were Dr_ Daniel Nathan, Johns (September 19) . Hopkins Schools of Medicine, of ASBMB. September 23 Congressional Biomedical Research Caucus' May 22 APS letter from Dr. Frank to House members in sup­ titled "Why Heart Attacks?" Speakers featured were Drs. port of funding for space lab. Michael Brown, University of Texas Health Science Center, June 7 FASEB letter from Dr. Edgington transmitting Con­ of ASBMB and ASCB; Robert J. Lefkowitz, Duke Univer­ sensus Conference report on Indirect Costs to Congress and sity Medical Center, of ASBMB and ASPET; and Howard administration. E. Morgan, Geisinger Clinic, Danville, Penn. of APS and June 7 ASPET Conference on steroid abuse report developed ASBMB. by Dr. Burks for Congressional staff and media. October 28 Congressional Biomedical Research Caucus' June 14 FASEB letter from Dr. Edgington to OMB support­ briefing title "New Frontiers in Cancer Research." Speakers ing additional unallowable costs under circular A-21. featured were Drs. Walter Lawrence, American Cancer So­ June 14 ASPET letter from Dr. Burks to Congressman Henry ciety; Samuel Broder, National Cancer Institute; J. Michael Waxman (D-Calif.) opposing Title III of NIH reauthoriza­ Bishop, University of California, San Francisco, of ASBMB tion legislation which called for a plan that implied that and ASCB; and Bert Vogelstein, Johns Hopkins University, any other alternative to using animals in research is better. of ASCB. June 19 ASPET letter from Dr. Burks to HHS Secretary November 1 ASPET letter from Dr. Standaert to President Louis Sullivan, Congressmen Waxman and John Dingell (D­ Bush on FY 1993 NIH and ADAMHA appropriations. Let­ Mich.), and Senators Edward Kennedy (D-Mass.) and Or­ ter was co-signed by the presidents of all other FASEB So­ rin Hatch (R-Utah) on ADAMHA reorganization. cieties. July 1 APS letter from Dr. Frank to U.S. Senate members November 14 APS letter by Dr. Frank to Senate members in support of funding for space lab. in support of legislation repealing the moratorium on fetal July 9 FASEB letter from Dr. Cousins to Senate LlHHS Ap­ tissue transplantation research. propriations subcommittee chair Tom Harkin (D-Iowa) on November 18 FASEB telegram from Dr. Cousins to all mem­ OMB Circular A-21 opposing reducing the ceiling on in­ bers of Congress urging override of President's veto of direct administrative costs. ASBMB also sent a letter from LlHHS appropriation bill. Telegrams were also sent by Dr. Schachman (July 10). ASBMB from Dr. Coon; ASCB from Dr. William R. Brink­ July 17 ASBMB letter to Office of Science and Technology ley, Baylor College of Medicine; and the Biophysical Society. Policy (OSTP) Director Dr. D. Allan Bromley on biotech­ December 10 APS letter from Dr. Frank urging House mem­ nology regulations. bers not to support HR3918, a bill to eliminate animal July 24 FASEB Alert from Dr. Cousins to FASEB society testing. members informing them of proposed scientific integrity Decem ber 12 FASEB Consensus Conference on FY 1993 regulations announced by the Office of Scientific Integrity Research Funding report from Dr. Cousins sent to members Review (OSIR). of Congress and key administration officials. July 25 FASEB letter from Dr. Cousins to OMB supporting a 26 percent cap on administrative indirect costs as an in­ 'The Congressional Biomedical Research Caucus is sponsored terim measure. Letters were also sent by APS from Dr. Frank by ASBMB, ASCB, and Biophysical SOciety. (July 23) and ASBMB from Dr. Schachman (July 19) . Federation Committees

Lxecutive Officers Publications Committee dvisory Committee Fredric W. Hill, Chair ~fichael J. Jackson, Chair* John A. \Villiams \tartin Frank Victor Ginsburg Charles Hancock Robert R. Ruffolo, J r. . Croker Thomas W. Tillack .-\. . Pitlick Douglas T. Fearon G ..--\llison Richard E. Pagano th f. Saunders lizabeth Marincola Emily Gray Research Conferences Advisory Committee Peter M. Howley, Chair inance Committee Frank Booth Francis J. Haddy, Chair Peter L. Pedersen nald W. Estabrook Brian M. Cox James A. Bain Earl H. Harrison \lichael W. Lieberman Warren J. Leonard All an L. Forbes Constance Oliver - therine Knight Clement L. Markert, Ad Hoc lehin S. Oka Michael M. Gottesman, Ad Hoc Robert B. Gunn James E. Smith, Ad Hoc J"hn R. Rice, Secretary*

3M Life Sciences ire Sciences Research Office Award Committee d\ isory CommiUee Herbert Tabor, Chair aId B. McCormick, Chair Jerome A. Dempsey fordecai P. Blaustein P. Michael Conn Richard M. Welch Vincent T. Marchesi Brooke T. Mossman Alan G. Goodridge Willard J. Visek John J. Cebra -\d rianne Bendich William C. Earnshaw ut!las B. Murphy Judith Hertzfeld

Women's Excellence in Science utive Committee Award Committee homasS. Ed~n~on, Cha~ Lora E. Rikans, Chair :abor Kaley Hannah V. Carey H..,ward Schachman Mary D. Barkley Hot S. Vesell Agnes B. Kane Peggy R. Borum rOI L Reinisch Eleanor S. Metcalf illiam R. Brinkley Elizabeth D. Hay rry Honig Donald L. D. Caspar

President and the EOAC are Ex officio non-voting members on all Committees. uti,'e Director is a non-vo ting member on all Committees. -\'Oling member. Federation Board of Directors

Federation Officers Robert J. Cousins President T homas S. Edgington, Past President Shu Chien Vice President Michael J. Jack on, Secretary Francis J. Haddy, Treasurer

Federation Board Robert J. Cousins, Chair

The American Physiological Society Shu Chien Stanley C. Schultz

American Society for Biochemistry and Molecular Biology Howard K. Schachman Elizabeth F. Ne~ufeld

American Society for Pharmacology and Experimental Therapeutics Thomas F. BlIrks Frank C . Standaert

American Association of Pathologists Thomas S. Edgington Michael A. Cimbrone, Jr.

American Institute of Nutrition Robert J. Cousins Donald B. McCormick

The American Association of immunologists Henry Metzger Frank W. Fitch

The American SOCiety for CeU Biology Sarah C. R. \gin Samuel C. Silverstein

Biophysical Society Joseph F. Hoffman Thomas E. Thompson

Appointed Officials Michael J. Jackson, Executive Director John R. Rice, Comptroller FASEB 9650 Rockville Pike • Bethesda, Maryland 20814-3998 I Telephone 301-530-7000 • FAX 301-530-7001