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Subject Index

Subject Index

Subject Index

A - cytochemical analysis 177 - lymph node (s. there) 5,286 - cytogenetic studies 177 - (s. there) 5,286,318 369 - cytoplasmic inclusions 188 - tunIor aspirated 371 ff. ' 32 - FAB classification 176 ATLL (adult T-cell leukemia I acid - FISH (fluorescence in situr lymphoma) 332 - acid a-naphthyl acetate esterase hybridization) 177 AT~ (all-trans retinoic acid) 205 (ANAE) 14, 336 - histologic sections 177 autOImmune hemolytic 82 -- .strong ANAE a~tivity 336 - hypoplastic 258 - aCld malt~se defiClency (glycogen - immunophenotyping 177 storage dIsease, type II) 125 - increased tissue mast cells 191 - acid phosphatase 13,14,61,71,341 - with megakaryocytic B -- cytochemical determination of abnormalities 198 13 - molecular genetic studies 177 Bartonella bacilliformis 401 -- high 61 - recurrence of AML with deficient Barton~llosis (Oroya fever) 19,401 -- reaction, focal or paranuclear maturation 251 basophils I basophilic 144 268 - subtypes - in blood smear 144 -- reaction with inhibition -- L3 177 - 39, 192 bl Tartrate 14 -- MO 180 - hyperbasophilic variant 200 Adam 5 reaction 220 -- Ml 180, 184 - larger ~asophilic cells 286, 288 - of the granules 254 -- M2 (5. there) 184, 191 - leukemIa, acute 256 African trypanosomiasis -- M3 (5. there) 199,201 - stippling 29, 80 (sleeping sickness) 393 -- M4 (5. there) 212-219 - tissue basophils 39 Chagas disease (South African -- M5 (5. there) 224-227 bcl-2 302 trypanosomiasis) 393 -- M6 (5. there) 232, 236 BCR I ABL Philadelphia (Ph) agranulocytosis 112 -114 -- M7 (5. there) 238 translocation 132, 142, 149 - bone marrow in 113 - type I blast 177 Bence-Jones myeloma 344 - cyclic 112 - type II blast 177 Berlin blue alcohol abuse, chronic 94 ANAE (acid a-naphthyl acetate - iron stain 9, 10 Alder-Reilly anomaly 44 esterase) 14 - reaction 71 alkaline phosphatase 61 106 angiosarcoma 377 Bernard-5oulier syndrome 115, 116 - high 61 ' anemia - giant platelet 116 - neutrophilic 106 - aplastic 99, 117 Beta ALL (acute lymphocytic Ilympho• -- biopsy 117 - ~-chain tetramers (H chains) 80 blastic leukemia) 142 ff. 177 178 -- classification 117 - ~-clucocerebrosidase, deficiency 259,262 ' , , -- diagnosis 117 of 120 - B-ALL 260 -- histologic examination 117 B~'!tler, test of Beutler 8 -- mature 264 -- secondary aquired forms 117 bilmear leukemia 273 - c-ALL with t(9;22) 177 -- in the strict sense 99 bilobed nuclei 201 - chromosome abnormalities 267 - of chronic diseases 78 105 Binet, CLL, staging system of Binet - coexistence of T-ALL and AML - diserythropoietic, cong;nital 301 274 (s. CDA) 99-102 biopsy, histologic examination of - with cytoplasmic graunules 265 - Fanconi anemia 117 . marrow ~iopsy 4 - electron micrographs 266 - Heinz body anemia 8 80 bIphenotypIc leukemia 273 - hand-mirrow form 271 -- hereditary 80 ' blast crisis (CML, acute phase) 143 - immunologic classification 177 - hemolytic (5. there) 80-87 blood 26-66 178 ' - hypochromic 78 - 80 - blood smear (5. smear) - mature B-ALL 177 - megaloblastic (s. there) 88 - 90 - cells in the blood, overview 23 - 25 - morphologic variants 271 - pernicous 88 - cytochemistry of 17 - ph-positive ALL 277 - refractory 155 - ~alignant NHL and Hodgkin's - pr~-c-ALL with t(4;11) 177 - sideroachrestic 78 dIsease, blood involvement 299 - T -lineage 268 - spherocytic 80 - parasites (s. there) 383 ff. -- involvement of the T-ALL antibodies - peripheral blood 3 and myeloid lines 275 - against components of the - rea.ct~ve blood changes 105 - vacuolation 262 cytoskeleton 371 - stammg methods (5. there) 7 -17 amegakaryocytic thrombocytopenia - organ-specific 371 19,20 ' 115 antigen B-Iymphocytes I B-celllymphomas AML (acute myeloid leukemia) 132 - immunocytochemical detection 23, 296, 301, 339, 342 176 ff. ' of cell-surface and intracellular - B-ALL 260,264 - atypias 196 antigens 18 - B-CLL 301, 313 - biological entities 177 aspiration (5. also needle aspiration) -- bone marrow section 313 - coexistence of T-ALL and AML 3-5 - B-PLL (prolymphocytic leukemia) 274 - iliac spine, posterior 3 301, 302, 308, 319

Subject Index I 409 - Burkitt-type B-ceillymphoma CD34 - positive stem cells 23, 25 - multinucleated megakaryocytes with starry sky makrophages 339 - colonies of 25 160 - CD30 (Ki-llymphoma) 342 CD41 238 - polyploid monoblasts 170 - large-cell CD56 344 CMPD (chronic myeloproliferative -- anaplastic 342 CD61 238 disorders) 132 -- high-grade 342 CDl03 303, 316 - histologic examination 132 - markers 302 CDA (congenital diserythropoietic - transient myeloproliferation 132 Boeck disease (sarcoidosis) 288,295 anemia) 99 - 102 CNS, leukemic involvement of CNS in bone marrow (5. also marrow) 3 - 5, - type I 99 acute leukemias and malignant 67-285 - type II 99 NHL 178 - abnormal 67 - type III, 99 coarse granular and globular PAS - in agranulocytosis 113 CE (naphthol AS-D chloroacetate reaction 261 - aplasias (5. panmyelopathies) esterase) 15, 70 complications 4 117-119 cells crystalline inclusion - B-CLL, bone marrow section 313 - in blood, overview 23 - 25 - CLL 306 - change in differential counts of - of erythropoiesis 26 - in myeloma cells 351 bone marrow in various diseases - immunocytochemical detection CSF cytology 178 77 of cell-surface and intracellular - in acute leukemias 278 - cytochemistry of 17 antigens 18 cytochemical analysis, AML 177 - differential diagnosis - sickle cells, demonstration of 5, 6 cytochemistry I cytochemical -- by iron stain 11 centroblasts 287 determination -- of a increase 106 - centroblastic-centrocytic lympho• - of acid phosphatase 13, 302 - ET, bone marrow smear in ET 133 ma (low-grade follicular lympho• - of blood, cytochemistry 17 - fibrosis 156 ma) 302,323 - of bone marrow, cytochemistry 17 - HCL, unusual nuclear form 313 centrocytic lymphoma 302 - of glycogen 10 - histologic examination of marrow CFU-GM (myelomonoblast) 23 - HCL (hairy cell leukemia) biopsy 4 Chagas disease (South African 302-309,313 - HIV infection 174 trypanosomiasis) 393 - immunocytochemical detection - Hodgkin disease, bone marrow Charcot-Leyden crystals 220 of cell-surface and intracellular infiltration 367 Chediak-Higashi anomaly 47 antigens 18 - hypoplasia 156 chloramphenicol 94 - of leukocyte alkaline phosphatase - malignant NHL and Hodgkin's chromatin pattern 171 (5. LAP) 13, 68, 132, 142 disease, bone marrow chromosomes - of peroxidase 12, 13 involvement 299 - ALL, chromosome abnormalities cytogenetic changes 142 - in myelofibrosis 135 267 cytokeratin 371, 383 - necrotic 42 - chromosome 9 and 22 t(9;22), cytopenia (5. also thrombocytopenia) - normal 67 long arms 142 115-117 - NSE (neuron-specific enolase), - chromosome 17, delation or - acellular 117 reaction in a bone marrow smear translocation of the short arm - peripheral 117 378 (del(17p) 156 - severely hypoplastic 117 - overview 23 - 25 - isochromosome 17q 142, 173 cytoplasmic - percentage of bone marrow cells - Philadelphia (Ph) chromosome - budding 238 found in smears 76 (5. there) 132, 142, 148 - vacuoles in leukocytes 42 - promyelocytic marrow 112 - trisomy 8 142 cytoskeleton, antibodies against - range of variation in the cellular cleaved cell 302 components of 371 and fat distribution of normal bone CLL (chronic lymphocytic leukemia) marrow 74 301 - reactive bone marrow changes 105 - atypical 308 - small intact vessels in the bone - B-CLL (5. there) 301, 313 o marrow smear 74 - staging system - variations in the cellularity of bone -- of Binet 301 marrow smears 73 -- of Rai 301 DAP IV (dipeptidylaminopeptidase borrelia (B.) - T-CLL 301 IV) reaction 15, 268 - B. duttoni 401 ~-clucocerebrosidase, deficiency of del(5)(q13;q31) translocation 166 - B. recurrentis 401 120 dendritic cells 23 breast carcinoma 373 MDS (myelodysplastic syndromes) - dendritic reticulum cells 23, 287 bronchial cell carcinoma (small-cell), 155 desmin 371, 381 tumor cells from 372 CML (chronic myeloid leukemia) Diamond-Black/an syndrome 117 brugia malayi 405 120, 132, 142 -153 differentiation 3 Burkitt-type B-ceillymphoma with - accelerated phase 143 dipetalonema (mansonella) perstans starry sky makrophages 339 - acute phase (blast crisis) 143 403 burr cells 32 - atypical 142 diseases (see syndromes) - blast phases 150 diserythropoietic, congenital -- myeloid blast phase 150 (5. CDA) 99 - blood picture 142 displacement of hematopoietic tissue - chronic 117 c -- myelomonocytic leukemia Down syndrome 132 (CMML) 142, 155, 160, 169, 170 dry tap, HCL 302, 314 29 -- phase 143 dyserythropoiesis 155 - in type III CDA 99 - erythroblastic phase 153 dysgranulocytopoiesis 155 c-ALL with t(9;22) 177 - granulocytic leukemia 142 - pre-c-ALL with t(4;11) 177 - lymphoblast phase 152 CD10 240 - megakaryocytic-megakaryoblastic CDS 305 phases 153 E CD11c 303, 316 - stages of 143 CDl9 344 CMML (chronic myelomonocytic EDTA 3 CD30 (Ki-1 lymphoma) 342 leukemia) 142, 155, 169, 170 29, 80

410 I Subject Index endothelial cells, vascular and sinus - relapsing fever 401 HCL (hairy cell leukemia) 302, 303, 23 fibrosis, bone marrow 156 309,313 enzyme activity in granulopoietic filaria loa loa 403 - cytochemistry and cytochemical cells, ~ enzyme 167 fine needle aspiration staining 302, 315 eosinophilia I eosinophilic (5. also aspiration) 5 - HCL-V (variant) 303,317 - AML with abnonnal eosinophils FISH (fluorescence in situ - immunocytochemistry 315 (M4Eo) 217,222 hybridzation) - tartrate inhibition 302 - granulocytes 39, 105 - AML 177 - unusual nuclear form 313 - hypereosinophilic syndrome - CML 149 HDN (hemolytic diseases of the (HES) lOS, 106 - inv(16) in interphase cells, FISH newborn) 80 - leukemias 106 technique 223 Hegglin anomaly 50 -- acute 253 fixation 16 HeiTmeyer's reticulocyte stain 8 -- with higher degree of - Schaefer universal fixative 16 Heinz bodies 8, 80 maturation 255 Flaming plasma cells, plasmacytoma - body anemia 8, 80 epithelioid cells 288 344,346 -- hereditary 80 erythremia, "pure", M6V subtype fluorescence in situ hybridzation - body formation 80 236 (FISH) 149 - body test of Beutler 8 erythroblastopenia foam cells 123 Hemalum nuclear stain 7 - acute 96 folic acid, deficiency of 89 hematopoiesis / hematopoietic - chronic (pure red cell aplasia) 99 fragmentocytes (schizocytes) 32, 82 - growth factors 106 - 111 - transient 96 -- effect of 111 erythroblasts 26, 96, 99 -- G-CSF and GM-CSF 106 - CML, erythroblastic phase 153 - ineffectual 155 - giant 99 G - tissue, displacement of 117 - with megaloblastic changes 157 - various cell lines 24 - multinucleated 99 gametocytes 383 , unstable 8 - nests or islands of 26 gammopathy, monoclonal 344 80 - 87 - proerythroblasts (5. there) 26, 96 gastric carcinoma, metastastic 375 - autoimmune 82 - transfonnation 142 Gaucher - classification 81 erythrocytes 29 - cells 120 - HDN (hemolytic diseases of the - familial polYld.obulia, with positive -- intense acid phosphatase newborn) 80 erythrocyte 'alkaline phosphatase reaction 122 hemophagocytic syndromes 138 - disease 120 - 122 127 -129 - normal 29 - pseudo-Gaucher cells 80, 120, 147 - familial hemophagocytic - polychromatic 29 G-CSF 106 lymphohistiocytosis 127 erythroleukemia, acute 232 giant cells, multinucleated 130 heparin artifact 42 erythrophagocytosis 80, 82 7 HES (hypereosinophilic syndrome) - malignant mastocytosis with glucose-6 - phosphate dehydrogenase IDS, 106 erythrophagocytosis 284 deficiency 8, 80 287 - pronounced in a case of M5b 226 glutathione reductase deficiency 8 - sea-blue 124 erythrophagocytosis in myeloma glycogen histocytosis cells 351 - cytochemical detennination of 10 - histiocytosis X 130, 131 erythropoiesis 26 - storage disease, type II - Langerhans cell 130 - disturbances of 78 ff. (acid maltase defiCiency) 125 - malignant 127 - dyserythropoiesis 155 GM-CSF 106 histologic - toxic disturbances 94 Golgi esterase, AML, subtype M2 194 - classification 5 esterases 14 granulocytes I granules - examination of marrow biopsy 4 - acid a-naphthyl acetate esterase - abnormal AML granules, dark HIV infections 105 (ANAE) 14 purple-violet 217 - bone marrow in 174 - Golgi esterase, AML, subtype M2 - agranulocytosis (5. there) 112 -114 Hodgkin 194 - artifacts 42 - cells 366 - naphthol AS-D chloroacetate - basophilic 39, 192 - lymphoma (lymphogranulomato- esterase (CE) 15 - degenerate fonns 42 sis) 299 ff., 366 ff. - neutral (naphthyl butyrate) 14 - eosinophilic 39 -- blood and bone marrow - nonspecific esterase reaction 69, - recurrence of AML with deficient involvement 299 159, 212, 316 granulocyte maturation 251 -- bone marrow infiltration 367 -- abnonnal 159, 167 - toxic changes and artifacts 42 -- classifications (Kiel, Real or ET (essential thrombocytopenia) - 42 WHO) 299, 366 132, 133 granulocytopoiesis -- cytologic features 366 - bone marrow smear in ET 133 - congenital anomalies 44 -- lymph node 369 - histologic section in 133 - early neutrophilic, localization of -- spleen 369 74 Howell-Jolly bodies 32 - high enzyme activity in HTLV (human T-cell leukemia virus) granulopoietic cells 167 332 - hypo granular cells 159 hybrid leukemia 273 F hydrolases 13 hypereosinophilic syndrome (HES) FAB classification 105, 106 - of ALL 264 hypernephroma 382 -- mature B IV 264 H hypnozoites 384 - of AML 176 78 faggots 199 H chains (P-chain tetramers) 80 hypoplasia, bone marrow 156 Fanconi anemia 117 hairy cell leukemia (s. HeL) 302,303, fetal hemoglobin, Kleihauer-Betke 309,313 stain for demonstrating 9 Hansen's bacillus (mycobacterium feveJ;. leprae) 19, 398 - Oroya fever (Bartonellosis) 19,401 HbF 80

Subject Index I 411 -- myeloid leukemia (5. AML) 176 I lymphocytic I -- secondary acute myeloid leuke- lymphatic system 23, 64 mia 247 - B-Iymphocytes I B-celllymphomas iliac spine, aspiration of posterior iliac -- therapy-induced changes 244 (5. there) 23, 296, 301, 339, 342 spine 3 - ATLL (adult T-cell leukemia I - CLL (chronic lymphocytic leuke• immunoblast I immunoblastic 286 lymphoma) 332 mia) 301 - lymphadenopathy 288 - chronic - LGL (large granulated ) immunocytochemical detection of -- lymphocytic leukemia (5. CLL) leukemia 301, 330 cell-surface and intracellular 301 ff. - SLVL (spleen lymphoma with antigens 18 -- myeloid leukemia (5. CML) 120, villous lymphocytes) 318 immunocytoma (Ie) 301 132,142-150 - T -lymphocytes I T -cell lymphomas immunophenotyping, AML 177 -- myelomonocytic leukemia (5. there) 23,296,301,325,326,341 inv(3)(q21;q26) 198 (CMML) 142, 155, 160, 169, 170 lymphogranulomatosis (5. Hodgkin inv(16)(p13;q22) 223 - eosinophilic 106 lymphoma) 299 ff., 366 ff. iron - HCL (hairy cell leukemia) 302, lymphohistiocytosis, familial - deficiency 78 303,309 ff hemophagocytic 127 - deposition in the motochondria - HTL V (human T -cell leukemia lymphoma 163, 165 virus) 332 - ATLL (adult T-cell leukemia I -- electron microscopic view 163 - LGL (large granulated lymphocyte) lymphoma) 332 - in plasma cell 95 leukemia 301, 330 - B-celllymphomas (5. there) 23, - stain 11, 122 - mast cell leukemias (leukemic 296, 301, 339, 342 -- Berlin blue iron stain 9, 10, 71 forms of mastocytosis) 280 - CD30 (Ki-1Iymphoma) 342 -- bone marrow, differential - monoblastic - centroblastic-centrocytic diagnosis 11 -- coexistence of residual MCL cells lymphoma (low-grade follicular isochromosome 17q 142, 173 and monoblastic leukemia 248 lymphoma) 302, 323 -- M5a subtype 227, 248 - centrocytic lymphoma 302 - monocytic, M5b subtype 224, 247 - Hodgkin lymphoma 299 ff. - NHL, low-grade, immune markers - malignant K in leukemic forms 300 -- CSF cytology 278 - NK-cellieukemia 330 -- non-Hodgkin lymphoma (NHL) Kahler disease - plasma cell leukemia 344, 358 299 ff. (5. also plasmacytoma) 344 - prolymphocytic leukemia 301, - mantle cell lymphoma 302,321 Kala Azar (visceral leishmaniasis) 302,308 - multiple myeloma, coexistence of 399 -- B-celllineage (B-PLL) 301, 319 lymphocytic lymphoma 356 karyorrhexis 99 -- cytogenetic analysis 302 - spleen lymphoma with villous Ki-1lymphoma (CD30) 342 -- T-cell lineage (T-PLL) 301, 336 lymphocytes (SLVL) 318 Kiel classification, NHL 299 - Sezary cell leukemia 325 - T-cell lymphomas (5. there) 23, Kleihauer-Betke stain for - T-cell leukemia 330 296, 301, 325, 326, 341 demonstrating - transition from megakaryoblastic - fetal hemoglobin 9 leukemia 241 - methemoglobin 9 leukocytes Klima needle 4 - alkaline phosphatase (s. LAP) 13, M knizocytes 32 68, 132, 142 Kostmann syndrome 115, 116 - AML 132 - concentrating 5 M subtypes, AML - cytoplasmic vacuoles 42 - MO 180 - inclusions 115 - M1 180,184 leukoerythroblastic reaction in - M2 184,191 L peripheral blood 376 -- variants ofM2 subtype 186-198 LGL (large granulated lymphocyte) - M3 199-205 L3 subtype, ALL 177 leukemia 301, 330 -- cytochemical findings 203 Langerhans cell 130, 288 - T- or NK-cellieukemia 330 -- electron microscopic view 209 - giant cells 288 light microscopic procedures 7 - 20 -- response to treatment with all- - histocytosis 130 lipophages 55 trans retinoic acid (ATRA) 205 LAP (leukocyte alkaline loa loa 403 - M3V 199 - 202 phosphatase) 13, 68, 132, 142 lymph nodes 5, 23 - 25, 286 ff. -- electron microscopic view 209 - cytochemical determination of 13 - aspirates I aspiration 5, 286 -- histologic section 201,202 leishmania (1.) I leishmaniasis -- cytology 286, 289 - 292 -- with increase of basophilic - cutaneous (oriental score) 401 -- fine needle 5 granulocytes 202 - L. donovani 399 -- monotonic picture 286 - M4 212,216 1. major 401 -- reactive cellular composition -- variants of M4 subtype 216 - 1. tropica 401 with specific cellular elements - M4Eo 217-219 - visceral (Kala Azar) 399 286 -- cytochemical findings 219 leprae I leprosy 19, 398 -- reactive cellular composition -- histologic section 221 - mycobacterium species 19 without specific cellular -- meningeal involevment 222 leukemia elements 286 -- with abnormal eosinophils 217 - acute - Hodgkin disese 369 - M5a 227 -- basophilic 256 - hyperplasia 287, 288, 293 -- monoblastic leukemia 227, 248 -- CSF cytology 278 - overview 23 - 25 - M5b 224, 226 -- eosinophilic 253 - storage cells 292 -- monocytic leukemia 224, 247 -- leukemic involvement of CNS in - touch preparations 286 -- pronaunced erythrophagocyto- acute leukemias and malignant - toxoplasmosis 294 sis 226 NHL 178 lymphadenopathiy, immunoblastic - M6 232 -- lymphoblastic leukemia 288 -- acute erythroleukemia 232 (5. ALL) 177, 178, 259 ff lymphadenosis, chronic 301 - M6V 236 -- megakaryoblast leukemia (M7) lymphoblasts 142,287 -- "pure"erythremia, M6V 132 - CML, lymphoblast phase 152 subtype 236

412 I Subject Index - M7 (acute megakaryoblastic - "pure" megakaryocytic myelosis leukemia) 132, 238 137 -- megakaryoblastic leukemia 238 - size variation 134 macroblasts 26 megakaryocytopoiesis, disturbances NK (natural killer)-cell neoplasias macroglobulinemia, Waldenstrom 155 361 344 megaloblast I megaloblastic naphthol AS-D chloroacetate esterase I system - anemia 88 - 90 (CE) 15,70 23,55 -- pathogenic factors 88 naphthyl - Burkitt-type B-celllymphoma with - erythroblasts with megaloblastic - acid a-naphthyl acetate esterase starry sky makrophages 339 changes 157 (ANAE) 14 - mitotic 90 - acetate 14 - monocyte-macrophage system 52 - butyrate (neutral esterases) 14 - "starry sky" 287,288 - sideromegaloblast 92 malaria megalocytes 29, 88 necrotic bone marrow 42 - malignant tertian 383, 384 meningeal involevment in M4Eo 222 needle (5. also aspiration) 3 - 5 - quartan 383, 384, 387 merozoites 383 - fme needle aspiration 5 - tertian 383 - 385, 389, 392 metamyelocytes 39,90,91 - Klima needle 4 mansonella (dipetalonema) perstans - giant 90, 91 - Rosegger needle 4 403 . methemoglobin, Kleihauer-Betke - sternal aspiration needle 4 mantle cell lymphoma 302, 321 stain for demonstrating 9 - Yamshidi needle 3 markers microfiliaris 19 neoplasiasis of tissue mast cells - B-cell 300, 302 micromegakaryocytes 155 (malignant mastocytoses) 280 - T-cell 300, 302 microscopy, light microscopic neuroblastoma 378 procedures 7 - 20 neurologic tumor cells in pediatric - tumor markers 371 patients 378 marrow / bone marrow (5. there) microspherocytes I microsphero• 3-5, 11 cytosis 29, 80 neuron-specific enolase (NSE) 372 mast cells 39 midline granuloma 362 neutropenia, severe congenital 115 - AML, increased tissue mast cells mitochondria, electron microscopic neutrophil / neutrophilic 191 view of iron deposition 163 - alkaline phosphatase 106 - atypical MDS 174 mixed - hypersegmented 92 mastocytoses, malignant (neoplasiasis - blast phases 142 - myelocytes 36, 39 of tissue mast cells) 280-285 - mixed lineage 273 newborn, HDN (hemolytic diseases - immature-cell 280, 282 Moeschlin technique, splenic of the newborn) 80 - leukemic forms 280 aspiration 5 NHL (malignant non-Hodgkin - mature-cell 280,281 monoblasts lymphoma) 178,299 ff., 339 -- systemic 280 - CFU-GM (myelomonoblast) 23 - blood and bone marrow - with erythrophagocytosis 284 - polyploid monoblasts of CMML involvement 299 mature-cell plasmacytoma 344 170 - centroblastic (large-cell, diffuse) Maurer spots 384 monoclonal gammopathy 344 339 monocytes 23, 52 - classifications (Kiel, REAL or Mayer's acid Hemalum nuclear stain WHO) 299 7 - monocyte-macrophage system 52 May-Grunwald stain 7 mononucleosis, infectious 296 ff. - high-grade malignant 299,303,339 May-Hegglin anomaly 50, 115 multinucleated giant cells 130 - intermediate grade 299 MCL cells, residual / monoblastic multiple myeloma - leukemic involvement of CNS 178 leukemia, coexistence of 248 (5. also plasmacytoma) 344 ff. - low-grade malignant 299, 300 MDS (myelodysplastic syndromes) mycobacterium species 19 -- immune markers in leukemic 155 - M. leprae (Hansen's bacillus) 19, forms 300 - atypical, increase in tissue mast 398 Niemann-Pick disease 123, 124 ceIrs 174 - M. tuberculosis 19 Nile blue sulfate stain 8 - signs of dysplasia 155 23,36, 142 NK (natural killer)-cell - subtypes 161 myelocytes 36, 39 - leukemia 330 I - band forms 39 - neoplasias 361 - blast type 155 nocturnal hemoglobinuria, - blast type II 155 - metamyelocytes (5. there) 39, 90, megakaryoblastoma 132, 138, 242 91 paroxysmal (5. PNH) 117 -119 megakaryoblasts / megakaryoblastic - neutrophilic 39 non-Hodgkin lymphoma, malignant 58, 132, 142, 241 - promyelocytes 36 (5. NHL) 178, 299 ff., 339 - acute megakaryoblastic leukemia - segmented forms 39 normoblasts 26 (M7) 132 myelodysplastic syndromes 157 NSE (neuron-specific enolase) 372 - CML, megakaryoblastic phase 153 - myelodysplasias with pseudo- - reaction in a bone marrow smear - electron microscopic detection of Pelger changes 171 378 platelet peroxydase in a mega• myelofibrosis, bone marrow in 135 karyoblast 243 myeloid - leukemia 241 - leukemia o -- basophilic leukemia 241 -- acute (5. AML) 132, 176 ff. -- transition from 241 -- chronic (5. CML) 120, 132, organ-specific antibodies 371 megakaryocytes I megakaryocytic 142-153 Oroya fever (Bartonellosis) 19, 401 58, 92, 132-138, 149, 153, 160, 198 - lines 275 osteoblasts 61 - AML with megakaryocytic abnor• myeloma osteoclasts 61 malities 198 - Bence-Jones 344 - with tumor cells 375 - CML, megakaryocytic phase 153 - multiple (5. plasmacytoma) 344 ff. osteomyelosclerosis 132 - CMML, multinucleated mega- myelomonoblast (CFU-GM) 23 karyocytes 160 myelodysplastic syndromes (5. MDS) - hypersegmented 92 ISS, 161, 174 p - isolated proliferation 132 myeloproliferative disorders, chronic - micromegakaryocytes 155 (5. CMPD) 132 - polyploid promegakaryocyte 58 myelosis, "pure" megakaryocytic 135 p53 gene 156 - pre~ursor cell leukemia 138 panmyelopathies (bone marrow aplasias) 117 -119

Subject Index I 413 - classification 117 - P. falciparum 383, 384, 389,392 - dendritic 23, 287 - secondary to cytostatic therapy or - P. immaculatum 389 - interdigitating 23, 287 irradiation 117 - P. malariae 383, 384, 387 rhabdomyosarcoma 380 panmyelophthisis 117 - P. ovale 383,384 - in histologic marrwo section 380 Pappenheim's - P. vivax 383-385 ribosome-lamellar complex (s. RLC) - stain 7 platelets 311-313 - 233 - dysfunction 115 Richter syndrome 343 pararosaniline solution 16 - giant 115 RLC (ribosome-lamellar complex) parasites in blood 383 ff. - peroxidase, electron microscopy 311-312 - cycle in the tissue 383 243 - electron microscopic appearance - detection of 19,20 PNH (paroxysmal nocturnal 312 - ring form 383 hemoglobinuria) 117 - 119 Rosegger needle 4 - trophozoites 383 - different stages of 119 Rosette arrangement of tumor cells in paroxysmal nocturnal hemoglobin• polychromatic erythrocytes 29 sympathicoblastoma 379 uria (5. PNH) 117-119 polycythemia vera 132, 134 formation, plasmacytoma parvovirus B19 infection 96 polyglobulia, familial, with positive 344 PAS (periodic acid Schiff) reaction erythrocyte alkaline phosphatase 105, 344 10, 70, 122, 233, 380 138 - large Russell bodies in the - coarse granular and globular PAS Pompe disease 125 cytoplasm of myeloma cells 350 reaction 261 Price-Jones curve 88, 89 pediatric patients, neurologic tumor proerythroblasts 26, 96 cells 378 - giant 96 Pelger-Huet anomaly 44 promegakaryocyte, polyploid 58 - pseudo Pelger-Huet forms 44, 142, promyelocytes I promyelocytic 36 156 - marrow 112 s peripheral blood (5. also blood) 3 prostatic carcinoma 375, 377 pernicious anemia 88 - histologic examination 377 sarcoidosis (Boeck disease) 288, 295 peroxidase protein globules, confluent 358 satellitism 116 - cytochemical determination of 11, pseudo Pelger Schaefer universal fixative 16 13 - myelodysplasias with pseudo- Schiff - partial defect 159 Pelger changes 171 - PAS (periodic acid Schiff) reaction - reaction 68, 212 - pseudo Pelger-Huet forms 44, 142 10, 70, 122, 233, 380 Phi bodies 183 - transformation 156 - reagent 10 Philadelphia (Ph) chromosome 132, pseudo-Gaucher cells 80, 120, 147 schizocytes (fragmentocytes) 32, 82 142, 148 pseudothrombopenia 115 schizonts 384 - extra Ph 142 Schuffner dots 384 - translocations (5. there) 132, 142, Schwachman syndrome 115 148,149, 166, 177, 184, 190, 191,211, sea-blue 124 302 Q Sezary Ph-positive All 277 - cell, electron micrograph of 327 plasma cells 23,64 5q-minus syndrome 156, 165 - cell leukemia 325, 328 - differential diagnosis of a plasma - syndrome (cutaneous T-cell cell increase 106 lymphoma) 325 - flaming 344 -- cerebri-form pattern 325 - leukemia 344, 358 -- highly convoluted nuclear plasmablasts 287 R fording 325 plasmacytic myeloma 344 sickle cells 32, 80 plasmacytoma 344 ff. RA (refractory anemia) 155 - demonstration of 5, 6 - Bence-Jones myeloma 344 - with excess blasts (5. RAEB) 155, sideroachrestic anemia 78 - coexistence of lymphocytic 156 sideroblasts, ringed 10, 78 lymphoma 356 - with ringed sideroblasts (RARS) siderocytes 32 - cristalline inclusion in myeloma ISS, 161, 165 sideromegaloblast 92 cells 351 RAEB (refractory anemia with excess sinus endothelial cells 23 - cytochemical staining 344, 351 blasts) ISS, 156 sleeping sickness (African trypano• - diffuse form 344 - in transformation 156 somiasis) 393 - erythrophagocytosis in myeloma Rai, ClL, staging system of Rai 301 SlVl (splenic lymphoma with villous cells 351 RARS (refractory anemia with ringed lymphocytes) 318 - extremely immature 347 sideroblasts) 155 smear I blood smear - Flaming myeloma cells 344, 346 - plasma cell, iron deposition 165 - preparation of 3, 4 - giant vacuoles 346, 348 - subtypes 161 - tumor cells in 372 - granular plasma cells 349 reactive blood and bone marrow - variations in the cellularity of bone - histologic section of 355 changes 105 marrow smears 73 - hypoplastic multiple myeloma 360 REAL classification, NHl 299 sodium nitrate solution 16 - immunocytologic differentiation reciprocal translocation 142 South African trypanosomiasis 344,353 red cell (Chagas disease) 393 - large Russell bodies in the cyto- - and white cell precursors 23, 94 spaghetti-like inclusion, Cll 307 . plasm of myeloma cells 350 - pure red cell aplasia (chronic spherocytes I spherocytic 80 - mature-cell 344, 346 ervthroblastopenia) 99 - anemia 80 - morphologic features 344 Reed-Sternberg cells 366 - microspherocytes 29 - multiple myeloma before and after refractory anemia (s. RA) 155 sphingomyelin 123 therapy 353 relapsing fever 401 sphingomyelinase, deficiency of 123 - plasmablastic type 347 reticular fibers in histologic section spleen 286 ff., 318, 369 - Rouleaux formation 344 314 - aspirates I aspiration 5, 286 ff. - solitary 344 reticulocytes 32 -- contraindication 5 plasmacytosis 105 - Heilmeyer's reticulocyte stain 8 -- cytology 286 plasmodium (P.) reticulum cells 23 -- Moeschlin technique 5 - d'fganisms 383 - central 26 - Hodgkin disease 369

414 I Subject Index - lymphoma with villous lympho- t(4;11) translocation 177, 267 transplantation, peripheral stem cell cytes (SLVL) 318 - pre-c-ALL with t(4;11) 177 72 sporozoites 383 t(6;9) translocation 192 trisomy 8 142 staining methods 7-17,19,20 t(8;14) translocation 267 trypanosomas (T.) - Berlin blue iron stain 9, 10, 71 t(8;21) translocation 184, 190, 191 - T. brucei 393 - blood parasites, detection of 19,20 t(9;22) translocation 148 - T. cruzi 395 - bone marrow, differential diagnosis - c-ALL with t(9;22) 177 - T. gambiense 393 by iron stain 11 t(11;14) translocation 302, 321, 322 - T. rhodesiense 393 - cytochemical 344 t(11;16) translocation 231 trypanosomes I trypanosomiasis 393, - Giemsa stain 7 t(14;18) translocation 302, 324 396 - Heilmeyer's reticulocyte stain 8 t(15;17) translocation 211 - African (sleeping sickness) 393 - Heinz body test of Beutler 8 T -ALL and myeloid lines 275 tuberculosis 19,288 - Kleihauer-Betke stain (5. there) 9 target cells 32 - mycobacterium species 19 - May-GrUnwald stain 7 Tartrate inhibition tumor aspirates I aspiration 5, 371 ff. - Mayer's acid Hemalum nuclear - acid phosphatase reaction 14 - fine needle aspiration 5 stain 7 - HCL 302 - immunologic methods 371 - Nile blue sulfate stain 8 toxoplasmosis 288 - markers 371 - Pappenheim's stain 7 tertian malaria 383 - Suaan black B stain 12 tetrasomy 8 231 - Toluidine blue stain 7 thalassemia 80, 120 staining results 3 - major 80 v Steinbrinck-Chediak-Higashi thrombocytopathies 115 anomaly 47 thrombocytopenia I thrombocyto- vacuolation 94 stem cell transplantation, peripheral penic 115-117 - in ALL 262 stem cell 72 - amegakaryocytic 115 vascular endothelial cells 23 sternal aspiration needle 4 - essential (5. ET) 132, 133 vimentin 371 stomatocytes 32 - idiopathic thrombocytopenic visceral leishmaniasis (Kala Azar) storage purpura (Werlhof disease) 115 399 - cells, lymph node 292 - pseudothrombopenia 115 vitamin B12, deficiency of 89 - diseases 120 ff. T-lymphocytes I T -cell lymphomas Sudan black B stain 12 23,296,301, 325, 326, 341 sympathicoblastoma, Rosette - cutaneous (Sezary syndrome) 325 . arrangement of tumor cells 379 - hig-grade, large-cell form 341 w synartesis 103 - low-grade lymphomas of T-cell syndromes I diseases (names only) lineage 326 - Bernard-Soulier (5. there) 115, 116 - markers 302 Waldenstrom - Boeck disease (sarcoidosis) 288, - T -ALL and myeloid lines 275 - disease 307 295 - T-CLL 301 - macroglobulinemia 344 - Diamond-Blackfan 117 - T-PLL (prolymphocytic leukemia) Werlhofilisease (idiopathic - Down 132 301,302, 308, 336 thrombocytopenic purpura) 115 - Gaucher disease 120 -122 Toluidine blue stain 7 white and red cell precursors 23, 94 - Hodgkin lymphoma 299 ff., 366 ff. toxoplasmosis 19, 294, 396, 397 WHO classification, NHL 299 - Kahler disease 344 transient myeloproliferation 132 wucheria bancrofti 403, 405 - Kostmann 115, 116 translocations - Niemann-Pick disease 123, 124 - bcl-2 302 - non-Hodgkin lymphoma (NHL), - BCR I ABL 132, 142, 149 y malignant 178, 299 ff., 339 . - del(5)(q13;q31) 166 - Pompe disease 125 - inv(3)(q21;q26) 198 - Richter 343 - inv(13)(p13;q22) 223 Yamshidi needle 3 - Schwachman 115 - t(1;22) 243 - Sezary 325 - t(3;12) 193 - Waldenstrom disease 307,344 - t(4;11) 177,267 - Zieve 82 - t(6;9) 192 z - t(8;21) 184, 190, 191 - t(8;14) 267 Zieve syndrome 82 - t(9;22) 148 T - t(11;14) 302, 321, 322 - t(11;16) 231 t(1;22) translocation 243 - t(14;18) 302, 324 t(3;12) translocation 193 - t(15;17) 211

Subject Index I 415

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