Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Abdelkari TUSM Cardiovascul Inflammato In the adult heart, cell death following TU Basic cell Bioche TBD Junior & m Sabri ar Research ry myocardial infarction initiates an Health and mistry Senior Center proteases inflammatory reaction that removes dead Science molecular and cardiac cells and contributes to scar formation Campu biology repair and cardiac repair. Since the regenerative s techniques. capacity of the adult mammalian heart is Highly limited, induction of this innate immune motivated response could be maladaptive and students compromises cardiac contractile function. with sound Our study uses a combination of in vivo knowledge and in vitro model systems to define the in cell and role of inflammatory proteases on molecular endogenous cardiac repair and function biology. after myocardial infarction. Adil I. adil.khan@ TUSM Pathology Role of In Vitro and in vivo assays would be used to TU Good writing Any TBD Sophom Khan PhD temple.edu and adhesion investigate the role of adhesion molecules in Health skills; be able science ore, Laboratory molecules models of acute inflammation. Science to work major. Junior or Medicine in acute Campus independentl Senior inflammati y. the work on. may involve a mouse models, so should be willing to work with live animals. CST Physics Accurate We are developing and improving electronic TU Physics TBD Junior Methods in structure methods based on many-body Main or Adrienn Ruzsinszky Electronic electron and density functional theory. Campus Chemist Structure ry

1 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Adrienn aruzsinszky CST Physics Electronic ground-state and/or excited state calculations TU interest in Physics, TBD Ruzsinszky @temple.e structure of layered semiconductors for nano- Main theoretical/c Chemist du of layered electromechanical device industry and Campus omputational ry semicondu photovoltaics research, ctors good computation al skills Adrienn CST Physics First- Development and applications of first- Temple Interest in Physics TBD Junior Ruzsinszky principles principles electronic structure methods in main theoretical or electronic Physics and Chemistry. campus research. Chemist structure Solid ry methods mathematical for background. materials Satisfactory programming and computation al skills. Alexandra CST Earth and Geochemic Student will be completing a detailed Main Completed Geology TBD Juniors Davatzes Environmen al analysis geochemical analysis of a section of rock Campus classes in or tal Science of a collected from an impact boundary. General Seniors Paleoarche chemistry an impact and event. Geochemistry or Petrology. Skilled in Excel; willing to work hard. - Gen Chem I, and Geochemistry or Petrology

2 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Allen anichol@te CST Biology Analysis of Proteomic analyses of protein-protein TU Interest in Biology, 10 to 15 Sophom Nicholson mple.edu a Gene- interactions in the bacterium Escherichia coli Main biochemistry Bioche ore, regulatory suggest that two ribonucleases, RNase III and Campus and mistry - Junior or Ribonuclea RNase II, as well as the protein YmdB, function molecular Biology Senior se Complex as a complex to process RNA molecules. We biology; 2112, will investigate how RNase III and RNase II may strong Genetic work in concert to process RNA, and how foundation of s, YmdB regulates the action of RNase III. These basic Chemist experiments will use purified recombinant biochemical/ ry proteins and RNA substrates to examine the biological activity of the protein complex and the concepts, individual proteins. critical thinking skills, attention to detail, willingness to tackle an early-stage research project.

3 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Allen anichol@te CST Biology Understan We apply biochemical and molecular genetic TU Strong Bioche 10 to 15 Sophom Nicholson mple.edu ding techniques to probe the mechanism of Main performance mistry, ore, ribonucleas ribonucleases and their function in gene Campus in biology Biology, Junior or e expression and RNA stability. Our primary and Chemist Senior mechanism system is the bacterial cell, and we seek to chemistry ry and understand how bacterial cell motility, biofilm courses majors function in formation, and response to stress are (including at gene regulated by ribonucleases. least one regulation semester of organic chemistry) Biology and Chemistry coursework through the sophomore year. Must have an eagerness to learn techniques, and be prepared to go the extra distance to complete occasionally challenging experiments

4 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce CST Biology Biogeograp Global patterns of biodiversity demonstrate TU Important TBD Sophom hic that most of the species on earth occur in the Main selection Biology, ore, variation in tropics, with strikingly fewer species occurring Campus criteria: A Environ Junior or interaction in higher-latitude regions. Biologists predict strong mental Senior strength that this global pattern of species diversity is academic Science and likely shaped by ecological species record, a invasions interactions. Yet few detailed experimental strong at the data exist that demonstrate how species interest in ocean's interactions influence ecological communities ecology and nearshore from the tropics to the arctic. Therefore, a conservation, (BioVision). significant opportunity exists to transform our and a desire understanding of how these fundamental to apply species interactions shape patterns of these biodiversity across the globe. Furthermore, interests in a these species interactions have the strong research potential to limit biological invasions by non- setting. Rele native species, which are often transported by vant human activities that breach historical coursework dispersal barriers, such as ocean basins and (Principles of continents. Biological invasions can cause Ecology, undesired ecological and economic effects and upper level are considered one of the primary drivers of ecology global change. Through extensive field and/or research on marine ecosystems along the conservation Pacific Coast of North and Central America, electives, from the tropics to the subarctic, this project is statistics, Amy amy.frees elucidating ecological factors that shape global etc.) is Freeston tone@te patterns of diversity and limit biological helpful e mple.edu invasions. but not required.

5 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Ana gameroa@ TUSM Biochemistr STAT2 STAT2 is a transcription factor widely TU Strong Biology, TBD Sophom Gamero temple.edu y Signaling in recognized for its role in host defense against Health knowledge of Bioche ore, Cancer microbial attack and inflammation. Published Science biological mistry Junior, work from my laboratory now suggests that Campus concepts Senior STAT2 is also implicated in cancer Self- development. We have evidence in animal motivated models of cancer that STAT2 functions to and promote tumorigenesis. Based on this exciting willingness to finding, the main objective of my lab is work hard determine the underlying molecular Good mechanism by which STAT2 is promoting communicati cancer development. on skills Able to work well with others gameroa@ TUSM Biochemistr Understan Cancer is a very complex disease driven by TU Good Biology, 9 to 12 Sophom temple.edu y ding the multiple genetic alterations. The focus of my Health communicati Bioche hours ore, Role of research is to investigate the mechanism by Science on skills, mistry per Junior, STAT2 in which the transcription factor STAT2 promotes Campus attention to week Senior Colorectal tumor progression in colorectal cancer. The detail and Cancer long-term goal of this project is to determine able to follow how STAT2 cooperates with tumor oncogenes directions to enable tumor progression, conversion of benign lesions to malignant and metastasis. Understanding this process will lead to the Ana Gamero development of novel therapeutic interventions to treat colorectal cancer.

6 11/1/16 Ananias Ananias.Esc CST Biology Phylomedic Our lab characterizes the processes shaping TU A minimum Biology, TBD Freshma Escalante alante@te ine of the genetic variation of vector-borne parasites Main of 3.7 GPA is Bioche n or mple.edu vector- and viruses. In particular, we utilize genetic Campus required. m, sophomo borne data to learn how pathogen populations Basic Applied re pathogens respond to the selective pressures exerted by knowledge Mathe the host immune system or antimicrobial on biology matics, drugs. By comparing genetic data derived from (transcription Natural historical samples and/or comparing /translation; Science pathogens genomes, we expect to provide DNA s information regarding which types of parasite structure and populations/dynamics are most prone to the replication) emergence of drug resistance or how genes and encoding antigens that are vaccine (or analytical/co diagnostic) targets change in time and space mputational compromising the efficacy of those public skills will be health interventions/tools. We also utilize the considered as parasite genetic information to ascertain selection ongoing epidemiological processes such as criteria. outbreaks or disease transmission patterns in Programming space. Our approach involves a suite of at a basic methods and models that include population level is genetics/genomics analyses, phylogenetics, considered a and experimental work. The students’ main plus, but it is role will be to assist in evolutionary genetic not required. analyses. We are looking for 1 or 2 students Students interested in analyzing genetic data (target should gene and genomic data) of malarial parasites interview (protozoa from the genus Plasmodium) and with the PI. flaviviruses. Both pathogens are vector-borne Our and are actively transmitted worldwide in expectation is tropical and subtropical regions. The students that the will assist in analyzing data generated in our selected lab and from public databases. candidates will continue to work with us after the summer.

7 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Ananias Ananias.Esc CST Biology Genetic I am looking for highly motivated students who Main Basic Biology, 15 Sophom Escalante alante@te diversity of are interested in gaining research experience. Campus knowledge Natural ore or mple.edu vector A minimum of 3.7 GPA is required. Students on biology Science Junior, borne should interview with the PI. Our expectation (transcription s, Math Freshma pathogens/ is that the selected candidates will continue to /translation; (applied n could parasites. work with us after the summer. Traditionally, DNA ) and be undergraduate students appear as co-authors structure and Comput consider in per-reviewed publications. replication) er ed OR Science analytical/co s - BIOL mputational 2112 skills will be considered as selection criteria. Anduo adw@tem CST CIS A My research interests center around improving Main good math, comput 10 seniors Wang ple.edu Consistent networked-systems with database techniques Campus programming er SDN and formal methods. My current research with Python, science Manageme projects focus on software-defined networks some nt Plane (SDN). understandin with Logic g of Reasoning networking and database Ann CST Chemistry Bioinorgani interested in hydrolysis- The Valentine Lab is TU intelligence chemist TBD Sophom Valentine c Titanium prone metal ions of biological relevance. The Main enthusiasm ry ore, Chemistry student will investigate possible ligand systems Campus conscientious bioche Junior titanium(IV) in a water for stabilization of ness - will mistry environment, will make and characterize new teach skills coordination compounds, and will inorganic necessary biomolecules evaluate their interactions with

Faculty Email Faculty Faculty Project Project Description Project Important Student Hours Class Name Address School Department title Locatio selection Majors Per Preferen or n criteria Desired Week ce College

8 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Bassel E sawaya@te TUSM Neurology/F Can HIV-1 Patients infected with HIV-1 suffer from TU Ask, Learn, All 15hrs/w Sophom Sawaya mple.edu els Institute proteins learning and memory deficit. The mechanisms Health Enjoy, - eek ore, promote leading to these alterations remain unknown. Science Serious, Junior, premature We are in the process of deciphering these Campus ability to Senior brain aging mechanisms learn and to interact with others 1- If the students does not have any lab experience, this will not work against him/her. Our mission is education and we are ready to help the student to require the min and necessary information that will help them to excel in their studies and we will make their lab experience rich as possible.

9 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Beata tug28074@ TUSM Department Mutation Emphysema is caused by the destruction of TU Biology TBD Kosmider temple.edu of Thoracic analysis in alveolar wall septa, which is associated with Health or Medicine emphysem inflammation. Alveolar type II cells make and Science Bioche and Surgery a. secrete pulmonary surfactant and restore the Campus m epithelium after damage. In our preliminary data we identified 6 mutations in genomic DNA obtained from alveolar type II cells isolated from patients with emphysema. Our hypothesis is that these mutations may contribute to this disease pathogenesis. Student task and responsibility: The student will first get training in general laboratory techniques. This person will be involved in planning experiments with a research group, preparing samples for DNA isolation and analyze sequencing results. We will meet at least once every week to discuss this project. The student will validate the functional role of these novel identified mutations in A549 cell line and human primary alveolar type II cells in vitro.

10 11/1/16 Beata tug28074@ TUSM Department The role of This person will be involved in determining the TU Biology TBD Kosmider temple.edu of Thoracic microvesicl role and mechanism of microvesicles secretion Health or Medicine es in in emphysema. The student will be responsible Science Bioche and Surgery emphysem to determine inflammatory response in control Campus m a. alveolar type II cells induced by microvesicles secreted in emphysema in vitro. Methods include standard molecular and cellular biology such as western blotting, immunocytofluorescence and ELISA. Microvesicles are small membrane vesicles of 30–1,000 nm in diameter that are released into the extracellular environment under normal or pathological conditions by different types of cells including alveolar type II cells. Our hypothesis is that microvesicles secreted in emphysema may contain inflammatory factors, which can induce injury of neighboring cells. In our preliminary data, we found higher microvesicles secretion in alveolar type II cells isolated from patients with this disease compared to control non-smokers and smokers. We have also identified dysregulated expression of genes involved in microvesicles synthesis by RNA sequencing in alveolar type II cells isolated from patients with emphysema. Student task and responsibility: The student will first get training in general laboratory techniques. This person will be involved in determining the role and mechanism of microvesicles secretion in emphysema. The student will be responsible to determine inflammatory response in control alveolar type II cells induced by microvesicles secreted in emphysema in vitro. Methods include standard molecular and cellular biology such as western blotting, immunocytofluorescence and ELISA.

11 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Bernd surrow@te CST Physics Automated This project requires a lot of hands-on lab TU Physics TBD Sophom Surrow mple.edu Leakage time. Main or Math ore, Current The student will develop a graphical user Campus Junior, Measurem interface (GUI) via MATLAB/LABVIEW that can Senior ents interact with the measurement devices, which supplies a voltage to a micropattern detector and reads the resulting current. The GUI will then be automated to record the voltage and current at a specific frequency, and plotting the values as a function of time. Applications concern the design of new detector systems for a future electron-ion collider (EIC) in the US and medical imaging applications. Bettina bbuttaro@ TUSM Microbiolog Enterococc Pheromone inducible conjugative plasmids, TU desire to chemist TBD Buttaro temple.edu y and al such as pCF10, play a central role in the ability Health learn to ry/bioch Immunology pheromon of Enterococcal faecalis to cause disease. They Science design and emistry e inducible encode antibiotic resistance and virulence Campus perform and conjugative genes in addition to mediating transfer of experiments biology plasmids as chromosomal determinants between strains. independentl virulence These plasmids also contribute to the ability of y under factors and the bacteria to cause disease and to spread guidance -- disseminat antibiotic resistance genes to other species Students are ors of and genera of bacteria. The goal of the given a antibiotic chemistry/biochemisty projects is to scientific resistance characterize the molecular mechanisms that question to genes allow the bacteria to vary the copy number of answer the plasmids in response to oxidative stress. experimentall The goal of the biology projects is to y. understand how the plasmid transfers antibiotic resistance genes to bacteria in mixed species biofilms.

12 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Bettina bbuttaro@ TUSM Microbiolog Antibiotic The plasmid makes helps make E. faecalis TU introductory Chemist 8-10 Any Buttaro, temple.edu y and Resistance antibiotic resistant and virulent. Current Health biology or ry and hours PhD Immunology Gene biochemistry projects focus on characterizing Science chemistry Biology Transfer how oxidative stress increases the number of Campus courses are Mediated plasmids in the bacterial cell. The biology sufficient by projects focus on how the plasmid transfers Enterococc antibiotic resistance genes to other bacteria in us faecalis mixed species biofilms. plasmid pCF10. Blair sbh@templ CST Biology Building a This project involves working with DNA TU strong normall flexible Sophom Hedges e.edu tree of life sequence data of diverse organisms, and Main academics y ore,Junio with DNA software, to help build the tree of life and Campus biology r data better understand evolutionary principles. It but takes place in the Center for Biodiversity and could mostly involves learning and using new be any computer tools and applications. The center is major located in SERC Building (www.biodiversitycenter.org) and the PI’s lab is www.hedgeslab.org. Blair sbh@templ CST Biology Conserving This project involves helping efforts in TU strong normall flexible Sophom Hedges e.edu the Temple’s Center for Biodiversity to learn more Main academics y ore,Junio biodiversity about the biodiversity of Haiti, and to protect Campus biology r of Haiti it. The multi-faceted team efforts include but discovery of new species, mainly through DNA could sequencing of samples collected in Haiti, be any ecological and evolutionary studies, and major educational and outreach components. The center is located in SERC Building (www.biodiversitycenter.org

13 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Bo Ji boji@temp CST CIS Software- The purpose of this project is to develop and TU Self- Comput TBD le.edu Defined implement resource allocation mechanisms in Main motivated. er Cellular software defined radio access networks. For Campus Backgrounds Science Networks this project, participants will be exposed to the in Electric basics of cellular networks (such as 4G LTE and networking, al WiMAX systems) and software defined control or Enginee networks. This is a multi-faceted project with math. ring both theoretical and systems aspects suitable for students with different background and interests. Participants with a theoretical interests will be provided projects such as algorithm design and performance analysis. Participants interested in system research can explore system-level simulations in open source simulators such as LTE-Sim and Open Air Interface, or potentially build experimental platform and implement the developed resource allocation mechanisms. Bo Ji CST CIS Allocation Network Function Virtualization and Software TU Good math CIS/Mat TBD Senior and Defined Networking are two emerging Main background h/ECE Placement technologies that enable rapid innovations in Campus and/or good of Virtual network provision, operation and programming Network management. This project concerns the skills. Basic Functions problem of allocation and placement of virtual knowledge in Software functions. about Defined networking Networks protocols.

14 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Bojana bojana.glig Enginee BioEngineeri Real-time Student would use multiphoton and confocal TU use of biology 15 seniors Gligorijevi orijevic@te ring ng imaging of fluorescent microscopes to image cancer cells Main microscopes, c mple.edu cancer cell labeled with 3 different fluorescent proteins. Campus sterile cell motility in The goal is to compare how motility of cells culture, cell the context relates to cell cycle stage distribution in 3D transfection of complex cellular spheroids embedded in collagen and environme matrix. We hypothesize that cells which are transduction, nts- motile will be arrested in G1 stage and that PCR, integrated spatially, such cells will be positioned in the microarrays, in vivo, in rim of the spheroid. The results have an immunofluor vitro, in application in the field of cancer drug escence or silico resistance, which is the main cause of histology... approaches remission today. Cancer cell motility in microenvir onment context CST Geology Ecological toxicity of nano-sized materials TU I will train Geology 10 to 15 Sophom hasn't been thoroughly evaluated. Through Main students for , ore or Phytotoxici this project, plant toxicity of metal oxide Campus proper skills Environ Higher ty of metal nanoparticles will be systematically examined. that need for mental oxide the project. Science, bkim@tem nanoparticl No skills Chemist Bojeong Kim ple.edu es needed. ry, Biology

15 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Brad rothberg@ TUSM Medical Crystal Potassium channels are membrane proteins TU Most Biology; 10 to 15 Juniors Rothberg temple.edu Genetics structures that are critical for electrical signaling in nerve Health important Bioche or and of and muscle cells. Our research is focused on Science criterion is a mistry; Seniors Molecular potassium crystallizing potassium channel proteins and Campus strong Chemist Biochemistr channel their regulatory domains, with the goal of interest in ry; y proteins solving the structures of these proteins using protein Neurosc X-ray diffraction. Note: This is expected to be a structure ience training experience, so previous experience in and/or X-ray crystallography is not required. neuroscience. Previous laboratory experience is preferred, but NOT required. Good communicati on skills are also preferred.

16 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Brent CST Biology Large-scale emerging fungal White-nose syndrome is an TU Coursework, Biology, 10 to 20 Sophom Sewall analysis of pathogen affecting hibernating bat Main training, or Environ ore, correlates .North America populations of eastern Campus experience in mental Junior or of appeared for the first time in Although it only relevant Science, Senior susceptibili 2006, it has already spread rapidly and has subjects such Mathe ty to white- had devastating effects, including the death of as statistics, matics, nose hundreds of caves and millions of bats across Geographic Comput syndrome, losses have important Such .mines Information er an implications for endangered species Systems, Science, emerging conservation biology, and the ,management epidemiology or pathogen ecology of natural communities in North , public related in disease, Little is known about the .America health, - hibernating but most research to date has focused on bat- ecology, or Statistic bats .site-level effects to-bat transmission and conservation s, the disease has spread ,Recently, however biology. Also Geogra across a broad geographic area, and an strong phic understanding of factors influencing improved motivation Informa disease is both the impacts and spread of the for research tion factors that may We will investigate .needed and strong Systems influence the susceptibility of bats to the interest in (GIS), or spread across large geographic disease and its this topic. Epidemi .scales ology (PBHL 3101) courses or bjsewall@te equival mple.edu ent (pre ferred

17 11/1/16 Brent CST Biology Influence Vertebrate frugivores (fruit-eating mammal TU Coursework, Biology, 10 to 20 Sophom Sewall of and bird species) play an essential ecological Main training, or Environ ore, vertebrate role, by facilitating the dispersal and Campus experience in mental Junior or frugivory germination of the seeds of a diversity of plant relevant Science, Senior on plant species. Vertebrate frugivory is therefore a key subjects such or seed determinant of the reproduction of many as ecology, related dispersal plants. Frugivory is especially important in the statistics, - Intro and tropics, where frugivorous primates, birds, and Geographic Series in germinatio bats disperse seeds for up to 90% of tree Information Biology n species in some forests. The foraging behavior Systems, (Bio and community ecology of most species of animal 1111, frugivore, however, are poorly understood. behavior, 2112) This lack of understanding hinders our ability conservation or to quantify the impact of specific frugivore biology, equival species on the plant community or to conserve and/or ent threatened frugivore species. In addition, French require frugivores are particularly vulnerable to language. d. hunting, fragmentation, and other human- Also strong Principl caused threats, but we still have only a motivation es of rudimentary ability to predict the effects of for research Ecology the loss of a specific frugivore species on the and strong (Bio plant community. The objectives of this study, interest in 2227) therefore, are (1) to investigate the influence this topic. strongly of frugivore feeding preferences and frugivore preferre interspecific interactions on seed dispersal and d. germination, (2) to examine the ultimate Statistic impact of frugivore species on the composition s, (Bio of plant species in natural ecosystems, and the 3254), regeneration of plant species in disturbed and/or ecosystems, and (3) to investigate means by Conserv which an improved ecological understanding ation of frugivores can contribute to their Biology conservation. (Bio bjsewall@t 3307) emple.edu preferre d.

Brent bjsewall@t CST Biology Conservati My lab is investigating multiple questions in TU Interest in Biology, 10 to 20 Sewall emple.edu on biology the fields of conservation biology and Main the field of Environ

18 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce and community ecology, focusing on Campus conservation mental community understanding human drivers of change in and off- biology or Science, ecology ecological systems and developing effective campus community Mathe conservation strategies. Ongoing research at field ecology; matics, projects focus on (1) understanding pollination sites experience or and seed dispersal interactions among species (may and skills in related in ecological communities, (2) clarifying the involve biology, fields influence of emerging infectious diseases on travel) math, and wildlife populations, and (3) identifying other management strategies to mitigate the relevant negative effects of human activities on plant fields; ability and animal communities. Research takes to conduct place both on campus and off-campus at field field work or sites. Work may require travel to remote sites, engage in hiking, and long hours of data collection in hot data and sunny or rainy conditions. Work may also manipulation require data entry, manipulation of data in or both; spreadsheets, and/or statistical analysis. willingness to work hard under sometimes difficult field conditions. Math and science courses relevant to the research topics.

19 11/1/16 Brent CST Biology Regional under threat from a Biological diversity is TU Coursework, Biology, 10 to 20 Sophom Sewall and global variety of local- and global-scale threats, Main training, or Environ ore, patterns of land use change, climate change, including Campus experience in mental Junior or threat to Ecologists and .and invasive species relevant Science, Senior biological worked for conservation biologists have subjects such or diversity decades to document patterns of biological as related and the threats facing biological diversity and the Geographic - identificati .diversity from the tropics to the poles Information Geogra on of large- efforts Recently, the results of some of these Systems phic scale have been compiled into several new spatially- (GIS), remote Informa spatial We will .global datasets explicit regional and sensing, tion conservatio datasets, along with Geographic use these statistics, Systems n priorities Information Systems software, to investigate ecology, or (GIS) and large-scale patterns of biodiversity conservation course change, and to identify spatial priorities for biology. Also (already to protect the Earth's conservation action strong taken or .biological diversity motivation concurr for research ent with and strong first interest in semeste this topic. r on this project) require d. Intro Bio series (Bio 1111 and 2112), Principl es of Ecology (Bio 2227), bjsewall@t and/or statistic emple.edu s

20 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce preferre d. Bruce Bruce.Vane TUSM Orthopaedic Study of In this study, we will review medical record of TU Biology TBD Sophom Vanett [email protected] Surgery and Risk knee arthroplasy patients and collect the Health ore or mple.edu Sports Factors for transfusion information and other clinical Science Junior Medicine Bleeding in information including pre-transfusion Campus Knee hemoglobin, and other factors which possibly Arthroplast associated with bleeding. y Patients Then we will analyze the data to identify the risk factors for bleeding during knee arthroplasty. Based on our results, we will revise our criteria for ordering blood before the knee arthroplasty and to decrease unnecessary requests for blood before surgery.

21 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Cagla ctukel@te TUSM Microbiolog Innate Amyloids, complex proteins with a conserved TU pipetting, Bioche 8 to 10 Juniors Tukel mple.edu y and immune beta sheet structure (1-4), are associated with Health agarose gel mistry, in Fall Immunology recognition complex diseases including, Alzheimer’s Science electrophore biology of bacterial disease, Prion Diseases and Type II diabetes. Campus sis, SDS-PAGE and amyloids Bacteria uses amyloids to decorate the chemist extracellular matrix of biofilms, highly ry structured multicellular communities that protect bacteria from insults and antimicrobial agents (5). Curli are amyloids expressed by enteric bacteria, including E. coli and Salmonella Typhimurium. Although human and bacterial amyloids do not have common amino acid sequence, they share a common quaternary structure and physical properties. We were the first to determine that Toll-like receptor (TLR) 2 of the innate immune system recognizes the amyloid fibers of both bacteria and human due to their common structure. We have recently determined that infection with curli-expressing bacteria or systemic exposure to purified curli triggers autoimmunity and accelerate of a human disease Systemic lupus erythematosus (SLE). The objective of the URP project is to determine the interactions of amyloids with DNA and how this interaction impact immune responses that leads to autoimmunity. Student will gain experience with protein purification, western blotting, polymerization experiments as well as cloning. If time allows student will learn to work with cell lines to determine the immune responses against bacteria that express amyloids. The information will help us identify a new role for bacterial infections in autoimmune diseases.

22 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Chiu C. cctan@tem CST Computer Security of There is a rise in everyday people using their Main General CIS, TBD Sophom Tan ple.edu and civilian- smartphones to record potential criminal acts, Campus interest in Math, ore, Information captured e.g. people rioting, violence in public spaces, security. Physics Juniors, Sciences videos and so on. Smartphones cameras are not Some Seniors designed to provide evidence of wrongdoing. familiarity The project will explore the potential security with video or issues related to civilian captured videos (e.g. photo potential for fake/tampered videos) and manipulation possible solutions to address them. software like Photoshop will be preferred. CST Computer Wearable use of wearable The project studies the TU Familiar with CIS/IST, TBD Sophom and Computers computing devices to monitor Main Android Math, ore, Information for Health patients with dementia disorders. The goal is Campus programming Junior, Sciences Care to develop systems and and/or Web Senior algorithms that can enable unobtrusive, long- programming term monitoring of high risk patients to improve early detection and measure effectiveness of cctan@tem treatment. The project is suitable for Chiu C. Tan ple.edu participants with strong .prototyping skills

Daniel dstrongi@t CST Chemistry Reactivity The iron sulfide, pyrite, is found at active and TU Motivation Chemist TBD Strongin emple.edu of Pyrite abandoned coal mining sites. Its Main Academic ry ESS and Acid decomposition in the environment leads to Campus performance Mine acid mine drainage (sulfuric acid generation) - Introductory Drainage which is a significant problems for coal mining Chemistry companies and the surrounding environment. Courses with The goal of the project is to look into strategies Laboratory. to suppress the oxidation of pyrite and the resulting acid generation.

23 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Darius darius@te CST Biology Redundant We are using a combination of molecular TU For more Biology, TBD Sophmor Balciunas mple.edu roles of Fli genetics techniques, from conditional gene Main information, Bioche e, junior transcriptio traps to CRISPR/Cas9 mutagenesis, to analyze Campus please see mistry n factors in the potential roles of two closely related the lab regeneratio transcription factors, fli1a and fli1b, in fin and website n heart regeneration in zebrafish. The project is http://www. currently being carried out by a graduating balciunaslab. senior, and should be taken over by a junior or com/research sophomore. - opportunities .html Darius darius@te CST Biology Precision Unlike humans, zebrafish possess a remarkable TU For more Biology, TBD Sophmor Balciunas mple.edu genome regenerative capacity, including the ability to Main information, Bioche e, junior editing regenerate their hearts after severe injury. We Campus please see mistry using are working to figure out which genes control the lab CRISPR/Cas this process and precisely how. To achieve this website 9 goal, we are using the CRISPR/Cas9 system to http://www. introduce precise changes into the zebrafish balciunaslab. genome, including integration of sequences com/research coding for epitope tags. We are looking for - several students to join this effort. One sub- opportunities project is to compare the efficiency of Cas9 .html nucleases from two different species, Streptocossus pyogenes and Streptocossus thermophilus. Other sub-projects include screening for CRISPR/Cas9-induced genome editing events and analysis of generated mutant lines.

24 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Eduard edragut@t CST CIS Identifying The project aims to develop methods that are TU Good Math, TBD Sophom Dragut emple.edu Entity capable to recognize substrings in user Main programming CS, ECE ore, Mentions messages that refer to an entity (e.g., Phila or Campus and analytic Juniors, in Social Philly refers to Philadelphia). skills. Ideally, Seniors Networking a student Streams who would like to pursue grad studies. Eduard edragut@t CST CIS Herveting This project aims to develop techniques that TU Good Math, TBD Sophom Dragut emple.edu User allow automatic harvesting of user comments Main programming CS, ECE ore, Comments from microblogs and other social networking Campus and analytic Juniors, from the websites. You will work with Java, Javascript, skills. Ideally, Seniors Social JSON, MySQL, and other modern Web a student Networking programming tools. who would Websites like to pursue grad studies. Eric eborguet@ CST Chemistry Combining Students will develop and use nanoscale TU Interest, Chemist 10 Sophom Borguet temple.edu Photons, plasmonic materials for rapid, high sensitivity Main curiosity and ry, hours ore or Electrons detection of biological and chemical agents, as Campus persistence - Physics per Junior and well as catalytic conversion. They will learn to Undergradua week in Nanoparticl use a variety of analytical techniques such as te the Fall es for spectroscopy, Atomic Force Microscopy researchers Plasmonic http://www.temple.edu/borguet/index.html in my group Sensing typically and present at Catalysis local, regional and even national conferences. Many have been co- authors on publications.

25 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Eric eborguet@ CST Chemistry Laser Research involves learning to use ultrafast TU Interest in Chemist 10 Sophom Borguet temple.edu Vibrational lasers (we make some of the shortest infrared Main research - ry hours ore or Spectrosco pulses in the world) to perform vibrational Campus Aptitude for Physics per Junior py and Sum Frequency Generation (SFG) a technique careful week in Dynamics that provides sensitivity to single molecualr laboratory the Fall of layers. Students will investigate water, research Molecular arguably the most important molecule on the Species at planet at interfaces of biological and Bio and geochemical relevance. Students will learn Geochemic about surface chemistry, biointerfaces, al geochemistry and laser spectroscopy. Interfaces Eric eborguet@ CST Chemistry Nanoparticl Develop novel plasmonic nanoparticles for TU Interest in Chemist 10 to 15 Sophom Borguet temple.edu e rapid, high sensitivity detection of biological Main research - ry hours ore or plasmonic and chemical agents. Students will learn to use Campus Aptitude for per Junior sensors for a variety of stat-of-the-art techniques such as careful week biological nanoparticle synthesis, optical and infrared laboratory and spectroscopy, Atomic Force Microscopy research chemical detection Fabio A. fabio.recchi TUSM Physiology New The general aim of this project is to identify TU Interest in biology, TBD Recchia a@temple. pharmacol new pharmacological and biological agents for Health the bioengi edu ogical and the therapy of heart failure and atrial Science biomedical neering, biological fibrillation in experimental dog models. These Campus field and bioche therapies are two major pathological conditions that potential mistry, for heart affect millions of Americans and there is a interest in kinesiol failure and pressing need for new therapies. Research in future ogy atrial large animal models is called "pre-clinical" in medical fibrillation that the related discoveries can be rapidly studies. At translated into clinical practice. least the basic courses of biology

26 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Fabio fabio.recchi TUSM Physiology New TU TBD Recchia a@temple. pharmacol Health edu ogical and Science biological Campus therapies for heart failure and atrial fibrillation

27 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce CST Biology The role of Normal cells became tumor cells through TU For Junior: Biology, TBD Sophom Pin1 in deregulation of multiple pathways. There are Main interest in Pharma ore, tumor some pathways that are altered in many Campus interdisciplin cology, Junior growth tumors and RB and p53 pathways are one of ary research; Chemist the most important. These proteins are basic ry. - regulated during carcinogenesis by a knowledge of Chemist phosphorylation mechanism. Ser or Thr molecular ry I, followed by Pro are major phosphorylation and cellular Chemist motifs in the cells but their significance was Biology or ry Lab I, obscure until the discovery of the PIN1 protein basic Chemist (protein interacting with NIMA (never in knowledge of ry II, mitosis A)- 1). optical Chemist Pin1 is an isomerase specific of pSer/Thr-Pro microscopy ry Lab motifs that catalyzed the conformational or basic II, switch from cis to trans, which is especially knowledge in Biology important because Pro-directed kinases and bio-chemistry I, phosphatases are conformation-specific and and basic Biology act only on the trans conformation. In vivo and tools for the Lab I. in vitro data have demonstrated that Pin1 is quantificatio involved in many aspects of cell cycle control. n of protein PIN1 was originally identified and defined as a and nucleic protein that function in mitosis. Since than, a acids plethora of protein targets have now been concentratio discovered many of which are involved in the ns - G0, G1/S control. motivation; The project’s focus will be studying the role of learning Pin1 in controls tumor cell proliferation capability; through the pRb and p53 proteins. In vitro and team ex vivo approach will be done to decipher how working; Pin1 controls transition from the G1 to S phase interest to rizzolio@te of cell cycle. We plan to develop new drug that obtain Flavio Rizzolio target Pin1 and, in turn affect tumor growth. scientific mple.edu results

28 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Frank spano@te CST Chemistry Photophtsi TU Chemist TBD Spango mple.edu cal Main ry Properties Campus of Histochemi cal Dye Aggregatio n

29 11/1/16 George george.smi TUSM Shriners Transplant The prospects of inducing long-distance TU Basic Neurosc 10 - 15 Juniors Smith th@temple Hospitals for ation of functional regeneration of supraspinal tracts Health understandin ience, or .edu Pediatric neural leading to connectivity and restoration of Science g of stem Biology, Seniors Research/N stem cells function remain a challenge. However, Campus cells, or euroscience to promote selective treatments induce sprouting, prevent immunochem Chemist circuit dieback, or induce short distance istry, and ry relays in regeneration. These processes, particularly molecular the injured sprouting, contribute to spontaneous recovery biology spinal cord. after injury by forming relays onto propriospinal interneurons that bypass the lesion and connect to caudal locomotor centers. Similarly, transplantation of neural stem cells or fetal spinal cord tissue into the lesion site is thought to increase functional recovery by recruiting supraspinal and propriospinal inputs to reinforce relays to downstream motor targets. To date, some of the best functional recovery has been observed in fetal transplants into neonatal animals most likely through formation of such relays. In adults, the addition of neurotrophins to the transplant site enhanced the number of ingrowing supraspinal and propriospinal axons and enhanced functional recovery, possibly by forming relays to bypass the lesion. However, it has never been directly shown that transplants induce recovery by relay formation. In this study, we will investigate the hypothesis that growth of supraspinal or propriospinal axons into neural progenitor transplants induce functional recovery by establishment of relays, and this process is greatly attenuated with maturation. To investigate this prospect, cervical spinal cord lesions and transplantation of neural restricted progenitors will be performed in 3, 10 and 60 day old rats. By selectively silencing the activity of transplanted neurons extending into

30 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce the caudal spinal cord we can assess functional recovery mediated by graft-host relays. The following aims then test the hypothesis that increasing and directing axon outgrowth from transplanted neurons, while increasing ingrowth of other pathways will enhance relay formation and forelimb function. For these studies we will examine relay formation using a 3 pronged approach 1) to identify the extent of host axons ingrowth and innervation on transplanted neurons, 2) shut down activity of transplanted neurons to determine their role in functional recovery, 3) apply neurotrophins to promote increased relay formation. Gillian gillian.quei CST Mathematic Grid The student researcher will work on Main Programming Mathe TBD Juniors Queisser sser@temp s generation developing automated ways to generate grids Campus skills matics, or le.edu and for the numerical computation of the Poisson- (scripting Comput Seniors convergenc Nernst-Planck (PNP) equations. PNP equations language er e analysis describe the behavior of charged particles and/or Science for the under diffusive and electrical fluxes. Using an object- Poisson- established numerical framework for solving oriented Nernst- the PNP equations this project will focus on language) Planck ways to automatically create test geometries and an equations (grids) and to use these to investigate the interest in convergence behavior of different numerical applied solvers. The goal is to streamline numerical mathematics testing and finding ideal numerical solvers for /numerics the PNP equations.

31 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Gillian gillian.quei CST Mathematic Simulating The student researcher will get to know novel Main Programming Mathe TBD Juniors Queisser sser@temp s networks simulation tools to simulate neural networks Campus skills matics, or le.edu of brain and use these tools to investigate the behavior (scripting Comput Seniors cells under of networks when connections between cells, language er synapse so called synapses, are lost. This effect is and/or Science, loss common in diseases like Alzheimer's and object- Biology identifying ways for cells to compensate oriented synapse loss is of great importance. The focus language) are of this project is to systematically simulate a plus. network behavior under various neuro- degenerative conditions with the goal of identifying cellular components that can compensate synapse loss. Gillian gillian.quei CST Mathematic Vector The student researcher will develop export Main Programming Mathe TBD Juniors Queisser sser@temp s graphic routines for scientific data in two and three Campus skills matics, or le.edu export of dimensions. The visualization of scientific data (scripting Comput Seniors two- and is critical when conveying new research language er three- results. The goal of this project is to develop and/or Science dimensiona ways to export ugx-data (an xml-based object- l scientific scientific computing file format) to vector oriented data graphics formats, such as svg. The students language) results can be included in broadly used open- source projects (uG4, NeuroBox and others).

32 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Gillian gillian.quei CST Mathematic Modeling In this project the student researcher will use Main Programming Mathe TBD Juniors Queisser sser@temp s and novel simulation tools to simulate and Campus skills matics, or le.edu Simulation evaluate the dynamics of calcium signals in (scripting Comput Seniors of Calcium neurons. Calcium is one of the most important language er Dynamics molecules in neuronal signaling and is and/or Science, in Healthy implicated in multiple ageing-related object- Biology and neurodegenerative diseases. The project will oriented Diseased focus on systematically simulating cell-calcium language) are Neurons dynamics under the influence of calcium a plus. regulating parameter sets representing healthy and disease-state neurons. The goal is to identify critical components in the calcium signaling cascade towards and into the cell nucleus, which eventually give rise to new insights into ageing-related diseases. Glenn S. tuf81289@ TUSM Medical A new Cellular hydrogen peroxide is associated with TU Team Bioche TBD Gerhard temple.edu Genetics thyroid cancer, although the source(s) and precise role Health oriented mistry and cancer remains unclear. We have identified a Science Prior Biology Molecular gene. candidate cancer gene in a family with a highly Campus laboratory Chemist Biochemistr penetrant dominant form of papillary (non- experience ry y medullary) thyroid cancer. A predicted Science GPA - damaging mutation in a transmembrane -If you work domain segregated with papillary thyroid with cancer in the family. We hypothesize that the zebrafish, be transmembrane mutation causes mis- prepared to localization of the protein to the cytoplasm get wet! with inappropriate intra-cellular production of hydrogen peroxide that subsequently leads to the development of papillary thyroid cancer in carriers of the mutation. Our aims are to determine whether the mutation causes oxidative stress in vitro and thyroid cancer in zebrafish and mice.

33 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Grace Ma grace.ma@ TUSM Center for Cancer, We have over 18 ongoing studies focusing on TU Good writing Any TBD Sophom temple.edu Asian Health CVDs, Cancer, CVDs, diabetes in underserved ethnic Health skills; be able fields, ore, & Clinical Diabetes- minority popualtions to reduce health Science to work with Junior or Sciences Ethnic disparities in clinical and community settings. Campus independentl health Senior population Go to "medicine.temple.edu/cah" y and team science s player, interest motivated s and reliable. preferre d Graham dob@temp CST Chemistry Exploring Organometallic complexes, which feature TU Prior Chemist TBD Dobereine le.edu the metal-carbon bonds, underpin key catalytic Main classroom ry r influence reactions in chemical industry. This project will Campus laboratory of Lewis explore the synthesis of new complexes using experience Acids on air-free technique, and investigate the (General Organomet reactivity of these complexes in new chemical Chemistry, allic reactions. and Compound preferably s Organic Chemistry).

34 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Gregory CST Chemistry Examinatio ,Humans perceive five basic taste qualities TU Grade point Biology, three Sophmor Smutzer, n of Human which include sweet, sour, salty, bitter, and Main average of Bioche hours e, Junior Ph.D. Chemosens humans readily ,umami taste. In addition Campus 3.0 or higher. mistry, per or Senior ory detect chemosensory irritants in the oral Ability to Chemist credit of Function and on the surface of the ,cavity, in the nose learn basic ry - researc skin. One important chemical irritant is lab h which is the pungent chemical that ,capsaicin techniques. .gives chili peppers their unique taste Standard lab Capsaicin is a vanilloid compound that skills include trigeminal nerves activates TRPV1 receptors in ability to in the oral cavity, and causes a stinging or prepare sensation in the mouth. We recently burning solutions, developed a novel delivery method for ability to use examining capsaicin perception in the human pipettes, and hydrophobic oral cavity by incorporating this ability to compound in edible taste strips. In addition, carry out identified compounds that we recently protein temporarily block the stinging sensation of assays. capsaicin in the oral cavity. Finally, we have Willingness chemosensation contains found that capsaicin to learn new both an olfactory and a trigeminal component. lab goal of this research project is to examine The techniques capsaicin the effect of inhibitors on such as perception in the oral cavity by means of mammalian mouth threshold studies, whole cell culture suprathreshold taste studies, and regional and surface. Experiments studies on the tongue fluorescence will also be undertaken to examine how these microscopy. block TRP receptors when these inhibitors gene products are expressed in a stable cell smutzerg@ line. Results from this study could lead to temple.edu treatments for effective oral and topical .chronic pain

35 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Gregory smutzerg@ CST Chemistry Inositol Although calcium is critical for the formation TU Willingness Bioche TBD Sophmor Smutzer, temple.edu 1,4,5- of dentin, the origin and regulation of calcium Main to learn new mistry - e, Junior Ph.D. Trisphosph during dentinogenesis is not known. Campus lab A year or Senior ate Odontoblasts are specialized cells that secrete techniques. - of Signaling in proteins and other molecules during the Standard lab General Mammalia formation of dentin in mammalian teeth. We skills Biology. n reported that secretory odontoblasts express including Biology Odontoblas high levels of the inositol 1,4,5-trisphosphate ability to Chemist t Cells. (IP3) receptor/channel, along with an prepare ry associated GTP-binding protein. This solutions, receptor/channel releases calcium from the ability to use endoplasmic reticulum of cells. We are pipettes, currently using cultured MDPC-23 cells as a ability to model for dentin formation. The goal of this carry out research is to demonstrate that the IP3 protein receptor, and a related GTP-binding protein assays, ability are expressed in differentiated MDPC-23 cells. to carry out In addition, calcium flux will be measured in SDS-gel differentiated MDPC-23 cells by the calcium electrophore indicator dyes Fura-2 and calcium green-1. sis, and basic These experiments will demonstrate the computer importance of IP3 signaling in controlling skills intracellular and extracellular calcium flux GPA of 3.0 or during the formation of dentin by odontoblast higher in cells science.

36 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce He Wang - He.Wang@ TUSM Pathology & Compare Despite significant improvement in short term TU Dedicated - bioche TBD Junior or tuhs.templ Lab microvascu survival, cardiac allograft vasculopathy (CAV) Health previous mical Senior e.edu Medicine lar disease remains the major cause of death in late Science exposure to science in right and survival transplanted patients. The definition Campus histology and or left of cardiac microvessel varies between authors, morphometri neurosc ventricular but a vascular diameter < 20 um is believed to c analysis are ience wall at be “micro-” by most investigators. Coronary preferred/not different microvascular bed is the site where myocardial absolutely time after blood flow is tightly adjusted to meet necessary heart myocardial metabolic needs. Coronary transplanta microvascular dysfunction is well documented tion in hypertension, obesity, diabetes, acute myocardial infarction, chronic stable angina, cardiomyopathies and heart failure with preserved ejection fraction.

37 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Hong hongw@te TUSM Center for Homocyste The objective of project is to study how TU Motivation, Biology TBD Wang mple.edu Metabolic ine and hyperhomocysteinemia (HHcy, is a medical Health carefulness - Disease Cardiovasc condition characterized by an abnormally high Science Students who Research ular level of homocysteine in the blood, Campus completed Disease conventionally described as above 15 µmol/L.) sophomore causes atherosclerosis. Since atherosclerosis is year. a pathological characteriostics of cardiovascular disease, which is the number one killer in the United States and developed contries. HHcy is the identified independent risk factor for CVD. However, the unberlying mechnism is unknown and ecffective therapeutis approaches are not available. Our laboraory is the leading laboratory in hyperhomocysteinemia and cardiovascular disease research. We have made significant contribution in this field. We are the first to report that hyperhomocysteinemia causes atherosclerotic changes in cell culture and mouse modles, and demonstrated essential cellular and molecular mechinsms.

38 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Hong hongw@te TUSM Center for Mechanism Cardiovascular disease is the number one killer TU GPA greater Biology, TBD Junior Wang mple.edu Metabolic of in the developed countries, but the Health than 3.4, Cell Bioche Disease metabolic mechanism remains largely unknown. Dr. Science culture or mistry, Research disorder- Wang’s laboratory is focused on exploring Campus Protein Comput induced molecular and biochemical mechanisms biochemistry er cardiovasc contributing to cardiovascular disease. The , Hard Science ular Wang lab has extensive expertise in the areas working and disease, of cardiovascular inflammation, dedicative DNA atherosclerosis, vascular function, molecular methylatio mechanism, and signal transduction. UPR n, studies will use bioinformatics, cell biology and monocyte molecular biochemical approaches to assess and stem the potential fundamental mechanisms. We cell will examine monocyte differentiation, differentiat vascular and systemic inflammation, vascular ion, cell growth control, apoptosis, gene expression vascular control and DNA methylation. Each UPR inflammati student will be instructed by a PhD student or on and a postdoctoral fellow. repair.

39 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Ilker K isariyer@te TUSM Neuroscienc Neuroimm Patients undergoing immune modulatory TU Biology, 10 to 15 Sophom Sariyer mple.edu e une therapies for the treatment of autoimmune Health Chemist ore,Junio regulation diseases such as multiple sclerosis, and Science ry, r,senior of JC virus individuals with an impaired-immune system, Campus Neurosc gene most notably AIDS patients, are in the high risk ience - expression group of developing progressive multifocal Previou in glial cells leukoencephalopath (PML), a fatal s demyelinating disease of the white matter experie caused by human neurotropic polyomavirus, nce in JC virus. We employ multidisciplinary bioche strategies to determine molecular mechanism mical of JC virus reactivation during the latent period lab of viral infection. JC virus replicates almost techniq exclusively in glial cells, and its promoter ues sequence, which has tissue-specific preferre characteristics, tightly modulates expression of d. viral genome in appropriate cell types and immunoconditions through communication with cellular factors. We identified the alternative splicing factor, SF2/ASF, as a potential regulator of JCV as its overexpression in glial cells strongly suppresses viral gene expression and replication. Our studies have demonstrated that SF2/ASF expression in glial cells is tightly controlled by immune mediators secreted by PBMCs suggesting a novel neuroimmune signaling between immune cells and glial cells that controls the gene expression and replication of the virus. In addition, a major effort in our laboratory is focused on biomarker potential of agnoprotein, a small regulatory protein of JC virus, for the early diagnosis and the prognosis of the PML.

40 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Ilker K. isariyer@te TUSM Neuroscienc Molecular Patients undergoing immune modulatory TU Talented with Biology TBD Sophom Sariyer mple.edu e regulation therapies for the treatment of autoimmune Health good work Pharma ore, of JC virus diseases such as multiple sclerosis, and Science ethics, cy Junior, reactivatio individuals with an impaired-immune system, Campus Senior n in the most notably AIDS patients, are in the high risk brain. group of developing progressive multifocal leukoencephalopathy (PML), an often lethal disease of the brain characterized by lytic infection of oligodendrocytes in the central nervous system (CNS). Immune system plays an important regulatory role in controlling JC virus reactivation from latent sites by limiting viral gene expression and replication. However little is known regarding the molecular mechanism of this regulation. My ongoing studies on JC virus and demyelinating disease, PML, are focused on understanding the molecular mechanisms involved in regulation of viral replication and gene expression during the course of JCV reactivation in immunocompromised individuals, discover potential biomarkers which will indicate JCV reactivation and develop effective therapeutic interventions for the treatment of PML.

41 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Ilya coast@tem CST EES/Geology Neoichnolo Analysis of modern structures (casts) and TU Ability to Geology TBD Sophom Buynevich ple.edu gy: Imaging georadar images of several large organisms Main work both , ore, of Animal (crustaceans, reptiles) that produce Campus independentl Environ Junior or Traces in bioturbation structures (burrows, nests) in y and as part mental Senior Coastal coastal settings (beaches and dunes). The of a research Science, Sediments findings will have implications to team, with a Biology, geomorphology, sedimentology/stratigraphy, possibility of Civil petroleum geology (macroporosity), field data Enginee geoarchaeology, geoforensics, and collection. ring conservation (e.g., sea turtle nests). Computer skills (especially MATLAB preferred, but not required). Introductory Biology and /or Geology courses Opportunity for presentation of results at a national Geological Society of America Conference (Baltimore - November 2015)

42 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Italo TUSM Fels Post- LMP1 is an important viral protein that is TU Must have Biology 15 Sophom Tempera Institute for translation expressed by Epstein-Barr virus, EBV, during Health completed or ore, Cancer modificatio latent infection. EBV is a human herpesvirus Science Biol 1111 Bioche Junior or Research ns of LMP1 that infects B cells and establishes a persistent Campus m Senior infection in 95% of the population worldwide. LMP1 plays an essential role in activating B cells and inducing cell proliferation. Targeting LMP1 is an important strategy that the host employs to counteract EBV infection. For example, cellular transcriptional repressors can bind the LMP1 promoter and block the expression of this viral protein. However other mechanisms can also control LMP1. We recently found that the cellular protein PARP1 can modify LMP1. PARP1 catalyzes the post- translational polymerization of ADP-ribose on target proteins, in a reaction called poly(ADP- ribosyl)ation, or PARylation. The incorporation of these long, negatively charged polymers of ADP-ribose alters the function of target proteins. Thus, we want to determine the effect of PARylation on LMP1 functions. The aims of the proposed project are: 1) to map the PARylation site of LMP1 by generating different LMP1 constructs and perform in vitro PARylation; 2) to transfect these LMP1 constructs in 293 cells and assess if they can tempera@t be PARylated; 3) to generate LMP1-PAR-null emple.edu mutants and study their effects on cell proliferation and cell transformation.

43 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Jamie payton@te CST Computer Assigning Mobile crowdsensing via smartphones enables Main Programming CS, 10 No Payton mple.edu and Tasks to mobile data collection on a massive scale and Campus (Java or C#) IS&T, or preferen Information Ensure has been widely used to investigate scientific Completion Math ce Sciences Coverage questions or address civic issues, such as of algorithms CIS in public safety, traffic planning, and and data 2168, Crowdsensi environment monitoring. Compared with static structures CIS ng sensor networks, mobile crowdsensing course 2033 Application leverages existing sensing and communication Exposure to (or s infrastructure without additional costs; statistics equival provides unprecedented spatio-temporal Critical ent), CIS coverage, especially for observing thinking 3223 unpredictable events; and integrates human intelligence into the sensing and data processing. However, new challenges are introduced due to data quality, inconsistency, security, and privacy. This project focuses on guaranteeing temporal and spatial coverage using crowdsensing participants while minimizing costs. We will define the coverage problem and develop participant selection algorithms to guarantee a given coverage requirement. The algorithms will be implemented and tested by the students using various real life mobile phone traces.

44 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Jie Wu jiewu@tem CST CIS Cloud Various distributed computing projects and TU CIS/IST, TBD Sophom ple.edu Computing testing have been run on our computing Main Math, ore, cluster. We maintain a virtual computing Campus Junior, platform in order to test our programs in Senior different environments and virtual hardware. Similarly we maintain a hadoop installation for projects that involve large data sets. An example of project that included both of these installations was a project which aimed to select the best virtual machine size depending on what kind of algorithm was used in hadoop. Recently, we’ve installed SDN switches to allow us to virtualize the network as well. This opens up the doors to a lot of novel research in the rising field of SDN. Jie Wu jiewu@tem CST CIS Wireless This project will be supported under the GENI TU CIS/IST, TBD Sophom ple.edu Networks project involving transferring large amounts of Main Math, ore, video data wirelessly to a processing server. Campus Junior, This research began with surveying the current Senior research in this field to find out what was already done. Once we had an idea of related research, we tested the wireless networks available on campus including Wi-Fi, 4G LTE, and our lab’s WiMAX tower located on the top of Wachman. After that, we formulated a couple different solutions which were implemented in Python using the POX software controlled networking (SDN) controller, and Java using the Floodlight controller. This research was written up and submitted to a national IEEE conference on wireless networking.

45 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Jocelyn jebehm@t CST Biology Biodiversity The reason we have food to eat, oxygen to TU Attention to Biology, TBD Behm emple.edu and breathe, and we’re not up to our shoulders in Main detail, Environ Ecosystem dead leaves is due to the services that Campus willingness to mental Services ecosystems provide us. Despite the clear work outside, Science importance of ecosystem services, we still organized have a lot to learn about how the diverse species in ecosystems perform these services. This project involves investigating how biodiversity contributes to ecosystem services.

Jocelyn jebehm@t CST Biology Evaluation Starbucks! Chipotle! Target! What do these TU Must be a Anyone TBD Behm emple.edu of “green” companies have in common? They sell Main creative, interest certificatio products with “green” certifications, but how Campus independent ed in n programs green are they? This project involves thinker with both for evaluating “green” certification programs for good ecology biodiversity how biodiversity is considered during the attention to and certification process. detail. Willin sustaina gness to bility learn new (biology skills , environ mental science, etc.)

46 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Jody Hey hey@templ CST Biology Evolution Student's will work on questions about how TU Freshmen all TBD Freshme e.edu and the the human genome has evolved. Some of the Main and majors n, Human work may involve comparisons with Ape Campus sophomores Sophom Genome genomes. with interest ores in bioinformatic s or in using computers to address important biological or medical questions. Jody Hey hey@templ CST Biology Evolutionar Students will use genomic data to address TU Freshmen all TBD Freshme e.edu y Genomics questions about natural selection and Main and majors n, adaptation Campus sophomores Sophom with interest ores in bioinformatic s or in using computers to address important biological or medical questions. Jody Hey hey@templ CST Biology Population Students will help develop mathematical and TU Freshmen Biology/ TBD Freshme e.edu Genetics statistical models of evolutionary processes Main and Math/C n, Campus sophomores ompute Sophom with interest r ores in Science mathematical and computation al biology

47 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Joel jbs@templ CST Biology Analysis of Immunohistochemical localization of specific TU Electrophores Biology TBD Junior & Sheffield e.edu microglia in antigens during development of the chick Main is, Senior retina and retina. Campus microscopy - pecten Bio 3096 is a plus. John Elrod elrod@tem TUSM Center for Investigatio The goal of these studies is to follow up on a TU Commitment Science TBD ple.edu Translationa n of large discovery-based screen and examine key Health to project or l Medicine candidate genes thought to play a role in necrotic cell Science beyond the Mathe genes death. Programmed necrosis is central to Campus summer matics identified numerous human diseases and the Work ethic by a identification of new pathways is paramount Previous lab genome- to designing new therapeutic strategies. experience wide, loss- Students will examine candidate genes and Self- of-function their role in death signaling using: cell culture motivated screen of techniques, generation of stable cell lines, viral individual cellular gene modification, cell death assays, and live- necrosis. cell imaging. Students are expected to actively participate in project design, understand the literature pertinent to the project, and complete experiments in a well-controlled and timely fashion. All project design and data interpretation will be performed jointly with the PI. If significant progress is made the student may be able to submit an abstract or contribute as an author on a published manuscript.

48 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Jonathan soboloff@t TUSM Fels Modulation Increases in cytosolic Ca2+ concentration are a TU Student must Biology/ TBD Sophom Soboloff emple.edu Institute for of calcium common component of multiple signal Health be Bioche ore, Cancer signaling by transduction pathways regulating a wide Science enthusiastic mistry Junior or Research changes in variety of responses ranging from rapid events Campus with a Senior STIM such as membrane fusion and muscle genuine expression contraction to control of proliferation, interest in differentiation and apoptosis. Since Ca2+ learning signals typically occur in a time frame of research. seconds to minutes, how Ca2+ transients can Prior lab regulate events that occur over hours to days experience is poorly understood. Recent investigations would be from our lab have led to the identification of highly Early Growth Response 1 (EGR1) as a regulator desirable but of the expression of STIM1, a required not required. component of store-operated Ca2+ entry, the Project primary means of Ca2+ entry in non-excitable involves cell cells. A student working in my lab will culture, investigate how the expression and function of Western STIM1 and EGR1 are coordinated in the blots, cloning context of receptor-mediated signals. and fluorescence microscopy. Joshua joshua.schr CST Biology Detecting We now have ancient DNA sequences from Main Some Math, 10 Juniors Schraiber aiber@tem inbreeding hundreds of early modern humans spanning Campus programming comput or ple.edu in ancient the last ~50 thousand years of human , some math, er Seniors humans evolution. Many of these individuals come willingness to science from nearby sites (such as individuals buried at bang head the same graveyard), raising the possibility against hard that they are related to each other. The problems student will develop an algorithm that BIOL 2112 OR estimates the relatedness of ancient samples MATH 1044 while accounting for genotype uncertainty due OR CIS 1057 to low coverage sequencing data, and use it to determine how inbred humans were during the colonization of Eurasia.

49 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Justin Y. shi@templ CST CIS Digital The lack of robust security in physical assets Main Basic CIS, 10 Juniors Shi e.edu Currency fostered the research in distributed crypto Campus knowledge of Physics, or and systems like block-chains. It has been shown programming Math, seniors Distributed that trust in distributed computing is a better and Enginee Computing form of currency than the physical currencies. cryptographic ring - However, while double-spending can be methods. CIS eliminated by the use of block-chains, 2168 challenges still exist in preventing money laundering, theft and other forms of cybercrimes.

50 11/1/16 CST Biology Does Patients who are obese are at an increased risk TU Motivation, Bio, TBD Sophom hyperinsuli of developing metabolic syndrome, Main interest in Bioche ore, nemia characterized by impaired glucose tolerance, Campus project and m or Junior or affect the abnormal plasmid lipids, hypertension and academic Neurosc Senior basal and development of Type II diabetes. Our accomplishm ience - induced laboratory has shown that Drosophila ent. Quick Comple levels of melanogaster lacking a functional sialic acid learner, ted Upd2 pathway display a range of metabolic defects, careful and Biology (leptin) in that are similar to those observed in patients good at 1111 Drosophila with Type II diabetes. We have demonstrated quantitiative and ? that one target of sialylation is a potassium skills. 2112 channel in the nervous system. We propose that the metabolic defects are a result of excess insulin secretion from insulin producing cells (IPC), due to channel dysfunction. Marban and Roth (1996) have shown that transgenic mice that secrete excess insulin (hyperinsulinemic) become insulin resistant, the hallmark of Type II diabetes. The mechanism of how hyperinsulinemia leads to Type II diabetes is not understood and is being actively studied. In both Drosophila and humans, the fat body (flies) or adipose tissue (humans) is a nutrient sensor, and in flies remotely conveys the nutrient status to the insulin producing cells. Under conditions of nutritional surplus, upd2, a petide hormone is secreted from the fat body and binds receptors on GABAergic neurons relieving their inhibitory effect on the IPCs to which they project, resulting in fly insulin (dilp2, 3 and 5) secretion. Rajan and Perrimon (2012) recently identified the cytokine Unpaired 2 (Upd2) as the functional homolog of human leptin. In humans, leptin produced by adipose tissue palter@te acts on the hypothalamus to regulate appetite Karen B. Paltermple.edu and energy expenditure rather than insulin secretion although it has many target tissues.

51 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce CST Biology Is there a Our laboratory has previously shown that TU Motivation, Bio, TBD Sophom functional Drosophila melanogaster lacking a functional Main interest in Bioche ore, sialic acid sialic acid pathway display a range of Campus project and m or Junior or pathway in metabolic defects, that are similar to those academic Neurosc Senior the insulin observed in patients with Type II diabetes. We accomplishm ience - producing have demonstrated that one target of ent. Quick Comple cells (IPCs) sialylation is a potassium channel in the learner, ted of nervous system. We hypothesize that the careful and Biology Drosophila metabolic defects are a result of excess insulin good at 1111 ? secretion from insulin producing cells (IPC), quantitiative and due to channel dysfunction. However, we skills. 2112 have been unable to detect any RNA encoding the sialic acid pathway enzymes by in situ hybridization in IPC cells in adult brains, and therefore, cannot rule out that the metabolic defects could result from defects in other brain neurons impacting the IPC cells. In order to establish whether the sialic acid pathway is functional in IPC cells, we have generated transgenic flies carrying an ectopic copy of the sialic acid synthase gene (SAS) under the Dilp2 (insulin promoter) that is active only in IPC cells. Fly strains were generated that express this transgene in a SAS 2d/2d (sialic acid synthese null) background and therefore will express the sialic acid synthase only in IPC cells. We wish to examine whether such flies will still exhibit the neuronal phenotypes characteristic of flies deficient in sialic acid (such as neurodegeneration), but will no longer display metabolic defects, establishing that the metabolic defects were due solely to palter@te loss of sialic acid in the IPC cells. A variety of Karen B. Paltermple.edu both behavioral and biochemical assays will be used to assay for metabolic defects.

52 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Karen palter@te CST Biology Investigatin Our laboratory has previously shown that TU Motivation Bioche TBD Palter mple.edu g the Drosophila melanogaster lacking a functional Main and interest mistry mechanism sialic acid pathway display a range of Campus in research. or of insulin metabolic defects. We hypothesize that the Biology 2112 Biology resistance metabolic defects are a result of excess insulin in Type II secretion from the insulin producing cells (IPC). diabetes We have generated transgenic flies carrying an ectopic copy of the sialic acid synthase gene (SAS) under a Dilp2 (insulin promoter) that is active only in IPC cells. Fly strains were generated that have this transgene in a SAS2d/2d background (null for SAS) and therefore will express the sialic acid synthase only in IPC cells. All transgenic flies are male sterile and all exhibit defects in locomotor activity, as did the original SAS mutant strain. However, all rescued strains no longer exhibit the metabolic defects characteristic of the SAS mutant strain, strongly suggesting that such defects were due to loss of sialic acid directly in the IPC cells. We have demonstrated that one target of sialylation (the addition of the terminal sugar to glycoproteins) is a potassium channel in the nervous system. We propose that the result of excess insulin secretion from insulin producing cells (IPC) were due to channel dysfunction. Marban and Roth (1996) have shown that transgenic mice that secrete excess insulin (hyperinsulinemic) become insulin resistant, the hallmark of Type II diabetes. mutant flies using both immunoblotting and quantitative PCR.

53 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Ke Chen kchen@te CST Physics Supercond Superconductors are superior materials for TU Skillful in Physics, TBD mple.edu ucting devices with phenomenal performance Main carry out Electric devices for compared to normal materials due to their Campus experiments enginee high zero dc electric resistivity and other unique in a lab. ring, performan quantum properties. This project will focus on Familiar with Chemist ce sensors fabricating and characterizing MgB2 (an electronics ry and circuits amazing superconductor) devices for high- and material speed circuits and high-sensitive magnetic field sciences. sensors. These applications are the current Interested in interest in defense, industrial, and many other solving areas. problems. General Physics I and II (either calculus based or not) Krishna kkant@te CST CIS Collaborati The project will involve simulation study of a TU The project TBD Kant mple.edu ve caching computer network designed for distributing Main would need in content content such as audio/video that is widely Campus good centric accessed and may have varying levels of programming networks demands from different parts of the network. skills, The purpose of the simulation is to study exposure to various collaborative policies for caching the discrete-even content. simulation, and basic background in computer networks.

54 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Krishna kkant@te CST CIS Reliability This project involves analysis of data collected TU The project TBD Kant mple.edu prediction from storage systems and its characterization Main would need of large relative to the observed errors that can be Campus good scale used for reliability prediction of the storage programming storage system. skills, systems exposure to discrete-even simulation, and basic background in computer networks. Laura laura.goetzl TUSM Obstetrics & Novel There has been limited methods for assessing TU Advanced, Neurosc TBD Juniors & Goetzl @tuhs.tem Gynecology noninvasiv fetal neurodevelopment during gestation in Health motivated, ience, seniors ple.edu e sampling human in-vivo models. Our new methodology Science interested in Biology, of fetal allows us to elucidate what elements of Campus research Pharma neurodevel abnormal neural development can be detected cy, opment in the maternal bloodstream. Medical through , fetal Psychiat derived ry, neuronal Gynecol exosomes ogy in maternal blood.

55 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Laura laura.goetzl TUSM Obstetrics & Placental In the placenta, SERT transports serotonin and TU TBD Goetzl @tuhs.tem Gynecology Serotonin amphetamines to the fetus. Prenatal exposure Health ple.edu Transporte to drugs, which triggers changes in placental Science r (SERT) is SERT expression, may also change fetal Campus Modified synaptic serotonin and serotonergic by neurotransmission. Maternal drug exposure Maternal may also alter SERT activity resulted in Opioid increasing and/or decreasing fetal exposure to Exposure: medications in early gestation. Our group is Implication investigating effects of maternal exposure to s for psychoactive medications during pregnancy, Altered including opioid exposure, on the activity of Fetal five placental transporters, such as SERT, NET, Vulnerabilit BCRP, MRP and P-gp. Our group, for the first y with time, found novel human SERT isoforms in Multi- opioid-exposed placenta. We study changes in Substance the level of expression of transporters in Use vesicles, their modifications and activity using various advanced techniques, including RNA studies by quantitative RT-PCR; protein studies including quantitative western-blot assays, protein sequencing or ELISA; fluorescence- based studies including FACS, microscopy, and functional bioactivity assays. Laura ltoran@te CST EES Stormwate Use data loggers, sampling, and other Philadel Comfortable Geology 15 sophorm Toran mple.edu r instruments to understand how stormwater phia with field , ore or monitoring moves through and affects urban ecosystems work and Environ higher with using mental computers to Science, analyze data. Physics

56 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Laurie laurie.kilpa TUSM Lung Regulation Dr. Kilpatrick’s research focuses on TU Some Bioche TBD Juniors Kilpatrick, trick@tem Center/Phys of investigating molecular mechanisms regulating Health previous lab mistry, or PhD ple.edu iology neutrophil- pro-inflammatory signaling in the innate Science experience, Chemist Seniors endothelial immune system; particularly the role of Campus highly ry, interaction activated leukocytes in the development of motivated Biology s in lung injury. An important focus of her work is with an bacterial examining the regulation of leukocyte interest in sepsis migration into the lung. Using both in vitro and research in vivo approaches, she is examining signaling pathways which regulate leukocyte- endothelial interaction and the control of transmigration. Her research group has extensive expertise with different models of inflammation in rodents and in the isolation and analysis of human neutrophils, monocytes and alveolar macrophages. Dr. Kilpatrick identified Protein Kinase C-delta (PKCδ) as a critical regulator of the inflammatory response in the lung. In translational studies, she is studying the use of directed anti-PKCδ therapy to the lung for the treatment of acute lung injury in a rodent model of sepsis employing pharmacological (PKCδ inhibitor) and genetic (PKCδ null mice) approaches. Current studies are investigating whether PKCδ inhibition could provide lung protection without compromising pathogen clearance, attenuate sepsis-induced damage to other organs, and improve survival.

57 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Lee-Yuan lliuche@te TUSM Center for Characteriz Lack of specific antibodies against the KOPR TU solid grades, Neurosc TBD Junior or Liu-Chen mple.edu Substance ation of a has hindered in vivo study of KOPR in terms of Health eagerness to ience Senior Abuse knockin localization, trafficking, expression and Science learn, Research mouse line signaling. My lab has generated a knockin Campus organized, & expressing mouse line expressing KOPR-tdT. The project is some lab Department a fusion to do genotyping of the mice and map the experience of protein of distribution of KOPR-tdT in the brain. preferred, Pharmacolo the kappa experience in gy opioid handling receptor rodents, (KOPR) and perfusion and the tissue fluorescent sectioning is protein a plus. tdTomato (tdT) [KOPr-tdT] Jocelyn jebehm@t CST Biology Evaluation Starbucks! Chipotle! Target! What do these TU Must be a Anyone TBD Behm emple.edu of “green” companies have in common? They sell Main creative, interest certificatio products with “green” certifications, but how Campus independent ed in n programs green are they? This project involves thinker with both for evaluating “green” certification programs for good ecology biodiversity how biodiversity is considered during the attention to and certification process. detail. Willin sustaina gness to bility learn new (biology skills , environ mental science, etc.)

58 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Jody Hey hey@templ CST Biology Evolution Student's will work on questions about how TU Freshmen all TBD Freshme e.edu and the the human genome has evolved. Some of the Main and majors n, Human work may involve comparisons with Ape Campus sophomores Sophom Genome genomes. with interest ores in bioinformatic s or in using computers to address important biological or medical questions. Jody Hey hey@templ CST Biology Evolutionar Students will use genomic data to address TU Freshmen all TBD Freshme e.edu y Genomics questions about natural selection and Main and majors n, adaptation Campus sophomores Sophom with interest ores in bioinformatic s or in using computers to address important biological or medical questions. Jody Hey hey@templ CST Biology Population Students will help develop mathematical and TU Freshmen Biology/ TBD Freshme e.edu Genetics statistical models of evolutionary processes Main and Math/C n, Campus sophomores ompute Sophom with interest r ores in Science mathematical and computation al biology

59 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Joel jbs@templ CST Biology Analysis of Immunohistochemical localization of specific TU Electrophores Biology TBD Junior & Sheffield e.edu microglia in antigens during development of the chick Main is, Senior retina and retina. Campus microscopy - pecten Bio 3096 is a plus. John Elrod elrod@tem TUSM Center for Investigatio The goal of these studies is to follow up on a TU Commitment Science TBD ple.edu Translationa n of large discovery-based screen and examine key Health to project or l Medicine candidate genes thought to play a role in necrotic cell Science beyond the Mathe genes death. Programmed necrosis is central to Campus summer matics identified numerous human diseases and the Work ethic by a identification of new pathways is paramount Previous lab genome- to designing new therapeutic strategies. experience wide, loss- Students will examine candidate genes and Self- of-function their role in death signaling using: cell culture motivated screen of techniques, generation of stable cell lines, viral individual cellular gene modification, cell death assays, and live- necrosis. cell imaging. Students are expected to actively participate in project design, understand the literature pertinent to the project, and complete experiments in a well-controlled and timely fashion. All project design and data interpretation will be performed jointly with the PI. If significant progress is made the student may be able to submit an abstract or contribute as an author on a published manuscript.

60 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Jonathan soboloff@t TUSM Fels Modulation Increases in cytosolic Ca2+ concentration are a TU Student must Biology/ TBD Sophom Soboloff emple.edu Institute for of calcium common component of multiple signal Health be Bioche ore, Cancer signaling by transduction pathways regulating a wide Science enthusiastic mistry Junior or Research changes in variety of responses ranging from rapid events Campus with a Senior STIM such as membrane fusion and muscle genuine expression contraction to control of proliferation, interest in differentiation and apoptosis. Since Ca2+ learning signals typically occur in a time frame of research. seconds to minutes, how Ca2+ transients can Prior lab regulate events that occur over hours to days experience is poorly understood. Recent investigations would be from our lab have led to the identification of highly Early Growth Response 1 (EGR1) as a regulator desirable but of the expression of STIM1, a required not required. component of store-operated Ca2+ entry, the Project primary means of Ca2+ entry in non-excitable involves cell cells. A student working in my lab will culture, investigate how the expression and function of Western STIM1 and EGR1 are coordinated in the blots, cloning context of receptor-mediated signals. and fluorescence microscopy. Joshua joshua.schr CST Biology Detecting We now have ancient DNA sequences from Main Some Math, 10 Juniors Schraiber aiber@tem inbreeding hundreds of early modern humans spanning Campus programming comput or ple.edu in ancient the last ~50 thousand years of human , some math, er Seniors humans evolution. Many of these individuals come willingness to science from nearby sites (such as individuals buried at bang head the same graveyard), raising the possibility against hard that they are related to each other. The problems student will develop an algorithm that BIOL 2112 OR estimates the relatedness of ancient samples MATH 1044 while accounting for genotype uncertainty due OR CIS 1057 to low coverage sequencing data, and use it to determine how inbred humans were during the colonization of Eurasia.

61 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Justin Y. shi@templ CST CIS Digital The lack of robust security in physical assets Main Basic CIS, 10 Juniors Shi e.edu Currency fostered the research in distributed crypto Campus knowledge of Physics, or and systems like block-chains. It has been shown programming Math, seniors Distributed that trust in distributed computing is a better and Enginee Computing form of currency than the physical currencies. cryptographic ring - However, while double-spending can be methods. CIS eliminated by the use of block-chains, 2168 challenges still exist in preventing money laundering, theft and other forms of cybercrimes.

62 11/1/16 CST Biology Does Patients who are obese are at an increased risk TU Motivation, Bio, TBD Sophom hyperinsuli of developing metabolic syndrome, Main interest in Bioche ore, nemia characterized by impaired glucose tolerance, Campus project and m or Junior or affect the abnormal plasmid lipids, hypertension and academic Neurosc Senior basal and development of Type II diabetes. Our accomplishm ience - induced laboratory has shown that Drosophila ent. Quick Comple levels of melanogaster lacking a functional sialic acid learner, ted Upd2 pathway display a range of metabolic defects, careful and Biology (leptin) in that are similar to those observed in patients good at 1111 Drosophila with Type II diabetes. We have demonstrated quantitiative and ? that one target of sialylation is a potassium skills. 2112 channel in the nervous system. We propose that the metabolic defects are a result of excess insulin secretion from insulin producing cells (IPC), due to channel dysfunction. Marban and Roth (1996) have shown that transgenic mice that secrete excess insulin (hyperinsulinemic) become insulin resistant, the hallmark of Type II diabetes. The mechanism of how hyperinsulinemia leads to Type II diabetes is not understood and is being actively studied. In both Drosophila and humans, the fat body (flies) or adipose tissue (humans) is a nutrient sensor, and in flies remotely conveys the nutrient status to the insulin producing cells. Under conditions of nutritional surplus, upd2, a petide hormone is secreted from the fat body and binds receptors on GABAergic neurons relieving their inhibitory effect on the IPCs to which they project, resulting in fly insulin (dilp2, 3 and 5) secretion. Rajan and Perrimon (2012) recently identified the cytokine Unpaired 2 (Upd2) as the functional homolog of human leptin. In humans, leptin produced by adipose tissue palter@te acts on the hypothalamus to regulate appetite Karen B. Paltermple.edu and energy expenditure rather than insulin secretion although it has many target tissues.

63 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce As upd2 is a potent regulator of insulin secretion in response to nutritional status in flies, we wished to investigate whether hyperinsulinemia directly alters Upd2 regulation, which may lead to insulin resistance. We will compare the levels of Upd2 RNA under fed and starved conditions in wild type and our SAS 2d/2d (sialic acid synthese null) flies which are hyperinsulinemic using quantitative RT-PCR. In addition, we have generated transgenic flies carrying an ectopic copy of the sialic acid synthase gene (SAS) under the Dilp2 (insulin promoter) that is active only in IPC cells. These rescued flies will also be examined for Upd2 regulation. Ke Chen kchen@te CST Physics Supercond Superconductors are superior materials for TU Skillful in Physics, TBD mple.edu ucting devices with phenomenal performance Main carry out Electric devices for compared to normal materials due to their Campus experiments enginee high zero dc electric resistivity and other unique in a lab. ring, performan quantum properties. This project will focus on Familiar with Chemist ce sensors fabricating and characterizing MgB2 (an electronics ry and circuits amazing superconductor) devices for high- and material speed circuits and high-sensitive magnetic field sciences. sensors. These applications are the current Interested in interest in defense, industrial, and many other solving areas. problems. General Physics I and II (either calculus based or not)

64 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Krishna kkant@te CST CIS Collaborati The project will involve simulation study of a TU The project TBD Kant mple.edu ve caching computer network designed for distributing Main would need in content content such as audio/video that is widely Campus good centric accessed and may have varying levels of programming networks demands from different parts of the network. skills, The purpose of the simulation is to study exposure to various collaborative policies for caching the discrete-even content. simulation, and basic background in computer networks. Krishna kkant@te CST CIS Reliability This project involves analysis of data collected TU The project TBD Kant mple.edu prediction from storage systems and its characterization Main would need of large relative to the observed errors that can be Campus good scale used for reliability prediction of the storage programming storage system. skills, systems exposure to discrete-even simulation, and basic background in computer networks.

65 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Laura laura.goetzl TUSM Obstetrics & Novel There has been limited methods for assessing TU Advanced, Neurosc TBD Juniors & Goetzl @tuhs.tem Gynecology noninvasiv fetal neurodevelopment during gestation in Health motivated, ience, seniors ple.edu e sampling human in-vivo models. Our new methodology Science interested in Biology, of fetal allows us to elucidate what elements of Campus research Pharma neurodevel abnormal neural development can be detected cy, opment in the maternal bloodstream. Medical through , fetal Psychiat derived ry, neuronal Gynecol exosomes ogy in maternal blood.

66 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Laura laura.goetzl TUSM Obstetrics & Placental In the placenta, SERT transports serotonin and TU TBD Goetzl @tuhs.tem Gynecology Serotonin amphetamines to the fetus. Prenatal exposure Health ple.edu Transporte to drugs, which triggers changes in placental Science r (SERT) is SERT expression, may also change fetal Campus Modified synaptic serotonin and serotonergic by neurotransmission. Maternal drug exposure Maternal may also alter SERT activity resulted in Opioid increasing and/or decreasing fetal exposure to Exposure: medications in early gestation. Our group is Implication investigating effects of maternal exposure to s for psychoactive medications during pregnancy, Altered including opioid exposure, on the activity of Fetal five placental transporters, such as SERT, NET, Vulnerabilit BCRP, MRP and P-gp. Our group, for the first y with time, found novel human SERT isoforms in Multi- opioid-exposed placenta. We study changes in Substance the level of expression of transporters in Use vesicles, their modifications and activity using various advanced techniques, including RNA studies by quantitative RT-PCR; protein studies including quantitative western-blot assays, protein sequencing or ELISA; fluorescence- based studies including FACS, microscopy, and functional bioactivity assays. Laura ltoran@te CST EES Stormwate Use data loggers, sampling, and other Philadel Comfortable Geology 15 sophorm Toran mple.edu r instruments to understand how stormwater phia with field , ore or monitoring moves through and affects urban ecosystems work and Environ higher with using mental computers to Science, analyze data. Physics

67 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Laurie laurie.kilpa TUSM Lung Regulation Dr. Kilpatrick’s research focuses on TU Some Bioche TBD Juniors Kilpatrick, trick@tem Center/Phys of investigating molecular mechanisms regulating Health previous lab mistry, or PhD ple.edu iology neutrophil- pro-inflammatory signaling in the innate Science experience, Chemist Seniors endothelial immune system; particularly the role of Campus highly ry, interaction activated leukocytes in the development of motivated Biology s in lung injury. An important focus of her work is with an bacterial examining the regulation of leukocyte interest in sepsis migration into the lung. Using both in vitro and research in vivo approaches, she is examining signaling pathways which regulate leukocyte- endothelial interaction and the control of transmigration. Her research group has extensive expertise with different models of inflammation in rodents and in the isolation and analysis of human neutrophils, monocytes and alveolar macrophages. Dr. Kilpatrick identified Protein Kinase C-delta (PKCδ) as a critical regulator of the inflammatory response in the lung. In translational studies, she is studying the use of directed anti-PKCδ therapy to the lung for the treatment of acute lung injury in a rodent model of sepsis employing pharmacological (PKCδ inhibitor) and genetic (PKCδ null mice) approaches. Current studies are investigating whether PKCδ inhibition could provide lung protection without compromising pathogen clearance, attenuate sepsis-induced damage to other organs, and improve survival.

68 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Lee-Yuan lliuche@te TUSM Center for Characteriz Lack of specific antibodies against the KOPR TU solid grades, Neurosc TBD Junior or Liu-Chen mple.edu Substance ation of a has hindered in vivo study of KOPR in terms of Health eagerness to ience Senior Abuse knockin localization, trafficking, expression and Science learn, Research mouse line signaling. My lab has generated a knockin Campus organized, & expressing mouse line expressing KOPR-tdT. The project is some lab Department a fusion to do genotyping of the mice and map the experience of protein of distribution of KOPR-tdT in the brain. preferred, Pharmacolo the kappa experience in gy opioid handling receptor rodents, (KOPR) and perfusion and the tissue fluorescent sectioning is protein a plus. tdTomato (tdT) [KOPr-tdT] Jocelyn jebehm@t CST Biology Evaluation Starbucks! Chipotle! Target! What do these TU Must be a Anyone TBD Behm emple.edu of “green” companies have in common? They sell Main creative, interest certificatio products with “green” certifications, but how Campus independent ed in n programs green are they? This project involves thinker with both for evaluating “green” certification programs for good ecology biodiversity how biodiversity is considered during the attention to and certification process. detail. Willin sustaina gness to bility learn new (biology skills , environ mental science, etc.)

69 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Jody Hey hey@templ CST Biology Evolution Student's will work on questions about how TU Freshmen all TBD Freshme e.edu and the the human genome has evolved. Some of the Main and majors n, Human work may involve comparisons with Ape Campus sophomores Sophom Genome genomes. with interest ores in bioinformatic s or in using computers to address important biological or medical questions. Jody Hey hey@templ CST Biology Evolutionar Students will use genomic data to address TU Freshmen all TBD Freshme e.edu y Genomics questions about natural selection and Main and majors n, adaptation Campus sophomores Sophom with interest ores in bioinformatic s or in using computers to address important biological or medical questions. Jody Hey hey@templ CST Biology Population Students will help develop mathematical and TU Freshmen Biology/ TBD Freshme e.edu Genetics statistical models of evolutionary processes Main and Math/C n, Campus sophomores ompute Sophom with interest r ores in Science mathematical and computation al biology

70 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Joel jbs@templ CST Biology Analysis of Immunohistochemical localization of specific TU Electrophores Biology TBD Junior & Sheffield e.edu microglia in antigens during development of the chick Main is, Senior retina and retina. Campus microscopy - pecten Bio 3096 is a plus. John Elrod elrod@tem TUSM Center for Investigatio The goal of these studies is to follow up on a TU Commitment Science TBD ple.edu Translationa n of large discovery-based screen and examine key Health to project or l Medicine candidate genes thought to play a role in necrotic cell Science beyond the Mathe genes death. Programmed necrosis is central to Campus summer matics identified numerous human diseases and the Work ethic by a identification of new pathways is paramount Previous lab genome- to designing new therapeutic strategies. experience wide, loss- Students will examine candidate genes and Self- of-function their role in death signaling using: cell culture motivated screen of techniques, generation of stable cell lines, viral individual cellular gene modification, cell death assays, and live- necrosis. cell imaging. Students are expected to actively participate in project design, understand the literature pertinent to the project, and complete experiments in a well-controlled and timely fashion. All project design and data interpretation will be performed jointly with the PI. If significant progress is made the student may be able to submit an abstract or contribute as an author on a published manuscript.

71 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Jonathan soboloff@t TUSM Fels Modulation Increases in cytosolic Ca2+ concentration are a TU Student must Biology/ TBD Sophom Soboloff emple.edu Institute for of calcium common component of multiple signal Health be Bioche ore, Cancer signaling by transduction pathways regulating a wide Science enthusiastic mistry Junior or Research changes in variety of responses ranging from rapid events Campus with a Senior STIM such as membrane fusion and muscle genuine expression contraction to control of proliferation, interest in differentiation and apoptosis. Since Ca2+ learning signals typically occur in a time frame of research. seconds to minutes, how Ca2+ transients can Prior lab regulate events that occur over hours to days experience is poorly understood. Recent investigations would be from our lab have led to the identification of highly Early Growth Response 1 (EGR1) as a regulator desirable but of the expression of STIM1, a required not required. component of store-operated Ca2+ entry, the Project primary means of Ca2+ entry in non-excitable involves cell cells. A student working in my lab will culture, investigate how the expression and function of Western STIM1 and EGR1 are coordinated in the blots, cloning context of receptor-mediated signals. and fluorescence microscopy. Joshua joshua.schr CST Biology Detecting We now have ancient DNA sequences from Main Some Math, 10 Juniors Schraiber aiber@tem inbreeding hundreds of early modern humans spanning Campus programming comput or ple.edu in ancient the last ~50 thousand years of human , some math, er Seniors humans evolution. Many of these individuals come willingness to science from nearby sites (such as individuals buried at bang head the same graveyard), raising the possibility against hard that they are related to each other. The problems student will develop an algorithm that BIOL 2112 OR estimates the relatedness of ancient samples MATH 1044 while accounting for genotype uncertainty due OR CIS 1057 to low coverage sequencing data, and use it to determine how inbred humans were during the colonization of Eurasia.

72 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Laurie laurie.kilpa TUSM Lung Regulation Dr. Kilpatrick’s research focuses on TU Some Bioche TBD Juniors Kilpatrick, trick@tem Center/Phys of investigating molecular mechanisms regulating Health previous lab mistry, or PhD ple.edu iology neutrophil- pro-inflammatory signaling in the innate Science experience, Chemist Seniors endothelial immune system; particularly the role of Campus highly ry, interaction activated leukocytes in the development of motivated Biology s in lung injury. An important focus of her work is with an bacterial examining the regulation of leukocyte interest in sepsis migration into the lung. Using both in vitro and research in vivo approaches, she is examining signaling pathways which regulate leukocyte- endothelial interaction and the control of transmigration. Her research group has extensive expertise with different models of inflammation in rodents and in the isolation and analysis of human neutrophils, monocytes and alveolar macrophages. Dr. Kilpatrick identified Protein Kinase C-delta (PKCδ) as a critical regulator of the inflammatory response in the lung. In translational studies, she is studying the use of directed anti-PKCδ therapy to the lung for the treatment of acute lung injury in a rodent model of sepsis employing pharmacological (PKCδ inhibitor) and genetic (PKCδ null mice) approaches. Current studies are investigating whether PKCδ inhibition could provide lung protection without compromising pathogen clearance, attenuate sepsis-induced damage to other organs, and improve survival.

73 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Lee-Yuan lliuche@te TUSM Center for Characteriz Lack of specific antibodies against the KOPR TU solid grades, Neurosc TBD Junior or Liu-Chen mple.edu Substance ation of a has hindered in vivo study of KOPR in terms of Health eagerness to ience Senior Abuse knockin localization, trafficking, expression and Science learn, Research mouse line signaling. My lab has generated a knockin Campus organized, & expressing mouse line expressing KOPR-tdT. The project is some lab Department a fusion to do genotyping of the mice and map the experience of protein of distribution of KOPR-tdT in the brain. preferred, Pharmacolo the kappa experience in gy opioid handling receptor rodents, (KOPR) and perfusion and the tissue fluorescent sectioning is protein a plus. tdTomato (tdT) [KOPr-tdT] LIQING JIN jinliqin@te TUSM Shriners molecular With molecular biological techniques, we TU Diligent - Medicin TBD mple.edu Hospitals mechanism study the role of local protein synthesis in Health biology, e or Pediatric s of axon axonal tips in axonal regeneration in lamprey Science biochemistry, biology Research regeneratio spinal cord. Campus molecular Center n in the biology, lamprey neuroscience, spinal cord etc. -- Students are welcome in our center.

74 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Madesh yson@te TUSM Biochemistr MCU gene We are creating a knockout zebra fish for the TU Prior Biology, 10 to 15 Juniors Muniswa mple.edu y knockout mitochondrial calcium uniporter (MCU) gene Health experience in Bioche or my using zebra using Crispr/Cas9. We plan to breed the Science a Biology/Life mistry, Sophom fish model homozygotes for the MCU deletion and then Campus Science Lab Molecul ore system use them for functional analyses. The goal is to Good ar measure how the deletion of MCU affects the Laboratory Biology ATP production/Calcium handling/Oxidative Practice stress in the mitochondria. General curiosity Bio 1, Bio 2, Genetics

75 11/1/16 Mahmut msafak@t TUSM Department Understan JC virus is a human polyomavirus that causes a TU Biology, TBD Sophom Safak emple.ed of ding the fatal disease, known as progressive multifocal Health Chemist ores and u Neuroscienc regulatory leukoencephalopathy, in the central nervous Science ry, Juniors e roles of JC system of a sub-population of Campus Bioche virus immunocompromised individuals including mistry, agnoprotei AIDS and cancer patients. This virus encodes a Neurosc n in viral small regulatory protein, Agnoprotein, from its ience life cycle late coding region. In the absence of its expression, this virus unable to sustain its productive life cycle. It is a highly basic phosphoprotein that localizes mostly to the perinuclear area of infected cells, although a small amount of the protein is also found in nucleus. It forms highly stable dimers/oligomers in vitro and in vivo through its Leu/Ile/Phe-rich domain. Structural NMR studies revealed that this domain adopts an alpha-helix conformation and plays a critical role in the stability of the protein. It associates with cellular proteins, including YB-1, p53, Ku70, FEZ1, HP1α, PP2A, and AP-3; and viral proteins, including small t antigen, large T antigen, HIV Tat, and JCV VP1; and significantly contributes the viral transcription and replication. Our most recent studies showed that it targets mitochondria and negatively regulates ATP production. It binds to viral RNA and CRM-1; and contains a nuclear export signal suggesting that it regulates viral RNA export from nucleus to cytoplasm for a regulated translation of viral transcripts. Our lab has a long-standing experience in training undergraduate students since 2001. More than 34 undergraduates have been trained in my lab. Most of those trainees have continued their education by attending professional schools, including MD and Ph.D.

76 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Mahmut msafak@te TUSM Department Investigatio Agnoprotein is one of the important regulatory TU Student with Biology, 8- Sophmor Safak mple.edu of n of the proteins of the human polyomavirus, JC virus. Health a good work Chemist 12hours e Neuroscienc regulatory It is a relatively small and basic protein. we Science ethics ry /week e roles of JC have recently demonstrated that it forms Campus Bioche virus highly stable dimers and oligomers. It exhibits mistry Agnoprotei the ability to be released from the infected Neurosc n in viral cells. The implications of this release unknown. ience life cycle It appears to bind to viral transcripts and ins involved in the splicing and nucleo-cytoplasmic transport of these transcripts. Three dimensional structure of this protein has been recently resolved by our lab, confirming the involvement of dimerization domain in alpha- helix formation. Our lab has been heavily involved in characterization of the regulatory roles of this protein in viral life cycle in the past and we will to do so for the next five year. This project has been recently funded by NIH and therefore there are ample opportunities for any prospective student to do research and understand the molecular mechanisms of action of this protein in JC virus life cycle. Marc A. mailies@te School Pharmaceuti Synthesis Carbonic anhydrase is a zinc metalloenzyme TU background chemist TBD Ilies mple.edu of cal Sciences and involved in many physiologic processes such as Health (organic ry, Pharma characteriz cellular respiration and transport of CO2 from Science chemistry), bioche cy ation of metabolizing tissues to lungs, pH homeostasis, Campus past mistry carbonic gastric acid secretion, bone remodelling experience, anhydrase gluconeogenesis, etc. It has 15 isozymes with motivation inhibitors different cellular localizations and biochemical and properties. Some of these isozymes are over- activators expressed in various disfunctions and diseases including cancers. We are interested to generate isozyme-selective inhibitors and activators for carbonic anhydrase with high intrinsic activity and in vivo efficacy.

77 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Marc Ilies mailies@te School Pharmaceuti Developme Drug delivery systems can modify the TU General Chemist TBD Freshma mple.edu of cal Sciences nt of drug pharmacokinetics of drugs, protect them from Health knowledge in ry, n to Pharma delivery decomposition and control their spatial and Science chemistry, Bioche Seniors cy systems temporal delivery in the organism. In recent Campus biochemistry, mistry, with years we were active towards the biology and Biology enhanced development of drug delivery systems based especially in in vivo on amphiphilic compounds of different the inter- stability molecular weight, from simple surfactants, disciplinary gemini surfactants, lipids, dendrons and integration of polymers. We are currently seeking talented this and highly motivated students to develop the knowledge is next generation of drug delivery systems with needed. We enhanced in vivo stability capable of long will train the circulation time in the body. Students majoring student in in chemistry, biochemistry and biology are the specifics welcomed. Experience in working with cells of the and animal models is a plus but it is not project. Will required. take Freshman to Seniors

78 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce School Pharmaceuti Physicoche Carbonic anhydrases (CAs, E. C. 4.2.1.1) are a TU previous Bioche 10 Sophom of cal Sciences mical and class of ubiquitous metallo-enzymes that Health experience in mistry, ore, Pharma biological catalyze the reversible hydration of carbon Science physicochemi Biology Juniors, - + cy evaluation dioxide: CO2 + H2O ↔ HCO3 + H . Sixteen Campus cal/biological Seniors of novel isozymes are currently known, with different evaluation of carbonic catalytic activity, subcellular localization and organic anhydrase tissue distribution. These isozymes are compounds inhibitors involved in critical physiologic and pathologic and their and their processes including respiration, acid-base formulations pharmaceu regulation, electrolyte secretion, bone (e.g. tical resorption/calcification, gluconeogenesis, liposomes), formulatio tumorigenicity and the growth and virulence as well as ns. of various pathogens. Some of them are over- towards expressed in pathological conditions such as handling cells edemas, glaucoma, obesity and cancer. constitutes a Therefore CA isozymes have become plus important targets for pharmaceutical research. We are seeking talented and passionate individuals to be involved in the physicochemical and biological testing of novel selective CA inhibitors and of their mailies@te pharmaceutical formulations aiming towards Marc Ilies mple.edu treatment of various forms of cancer via novel drugs and drug delivery systems.

79 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Maria iavarone@t CST Physics Low Superconducting ultrathin films and islands TU The students Physics 3-9 Junior & Iavarone emple.edu Temperatu will be fabricated on different substrates in Main should be - hours Senior re STM ultra high vacuum environment and Campus very General per Characteriz characterized by scanning tunneling interested in Physics I week ation of microscopy and spectroscopy. research and and II. Supercond very Introdu ucting motivated to ction to Nanostruct learn. quantu ures m mechan ics is optional .

80 11/1/16 Maria tug00270@ CST Biology Biodiversity , the ecology and evolutionary biology of TU Highly Biology, TBD Freshma Pacheco temple.edu and parasitic organisms are worthy of study in their Main motivated. A Applied n or evolution own right despite the challenges that these Campus minimum of Math, sophomo of parasites organisms pose as relatively unknown 3.7 GPA. Natural re elements of biodiversity. Indeed, our ability to Basic Science understand the processes shaping parasite knowledge s, diversity and to mitigate threats to that on biology Informa diversity is limited by gaps in our knowledge of (transcription tion issues such as species delimitation, population /translation Science structure and spatial distribution, and the and DNA and dynamics of assemblages which include replication), Technol multiple parasite and multiple host species. analytical/qu ogy, This project seeks to characterize multiple antitative Comput dimensions of the eukaryotic endoparasite skills and er biodiversity. In particular, we will give special curiosity are Science attention to malarial parasites in the genus required. s Plasmodium and other related parasitic Programming protozoa. These species belong to a diverse at a basic monophyletic group that is found in a broad level is range of vertebrate hosts, including primates, considered a lizards and birds. The long-term goals of this plus, but it is investigation are (i) to characterize geographic not required. patterns of parasite assemblages in birds and Our primates; (ii) to explore the functional and expectation is ecological interactions of a group of malaria that the parasites sharing one or more hosts in selected common; and (iii) to investigate the genetic candidates diversity, host adaptations and speciation of will continue malaria parasites infecting several host to work with species. The students’ main role will be to us after the assist in developing a database of parasites summer. genetic data and their host by mining Traditionally, published data. They will also assist on basic undergraduat evolutionary genetic analyses. e students appear in per-reviewed publications.

81 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Marion marionc@t TUSM Microbiolog The action Tumors constitute from heterogeneous cell TU Good work Biologic 3 to 9 Sophom Chan emple.edu y of dietary populations. Within them are a group of self Health ethics, al hours ore, phytochem renewing and differentiating stem cells, Science punctual, Science per Juniors icals on named tumor initiating cells or cancer stem Campus analytical s week ovarian cells (CSCs). These CSCs have been regarded thinking, related dependi cancer cells as the cause of drug resistance and metastasis. dexterity majors ng on The goal of our project is to test whether and course certain dietary phytochemicals (curcumin, Chemist credits EGCG, quercetin, resveratrol) and ry pharmaceutical small molecules (metformin, majors - niclosamide, thioridazine) are effective in Basic/In eliminating CSC population in ovarian cancer. troduct Students will learn sterile technique, pipetting ory accuracy, tissue culture techniques, drug Biology testing protocols and how to isolate human ovarian CSCs from the cell lines A2780 and C200 Matthew mrhelmus CST Biology The Tadpoles just want to grow up to become TU Basic Courses TBD Helmus @temple.e genomics frogs, but in nature there are plenty of Main computer in du of scared predators. Luckily, tadpoles have a defense-- Campus programming Genomi tadpoles when exposed to predators, tadpoles can cs or radically change their body shapes and Comput musculature so that they are harder for er predators to catch. The goal of this project is Progra to analyze experimental genomic data (already mming collected) to determine gene expression during body changes. Bioinformatics that may be used are: R statistical programming, Galaxy bioinformatic pipelines and BLAST2GO software.

82 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Matthew mrhelmus CST Biology Are there Natural selection has caused a spectacular TU Basic excel Biology, TBD Helmus @temple.e universal amount of biodiversity, from flying frogs to Main Environ du patterns in legless lizards, yet this evolution is not Campus mental biodiversity random. For example, on distant oceanic Science ? islands, species have evolved from the same types of natural selection, converging to similar body shapes and sizes. The goal of this project is to identify these universal patterns in biodiversity using specimens of lizards and frogs from across the Caribbean. The student will measure the body traits of the specimens and then build, using the R statistical programming language, genetic trees of evolutionary relationship of species to identify convergence in biodiversity. CST Chemistry Preparatio We are seeking undergraduates to aid in the TU GPA, Chemist TBD Sophom n and synthesis of salt-organic hybrid electrolyte Main Intent to ry - ore, testing of materials by co-crystalizaiton methods, and Campus pursue General Junior or solid the assessment of their conductivity using Graduate Chemist Senior electrolytes electrochemical techniques. education. ry for battery Skills from complet application General ed, s Chemistry Organic and Organic chemist Chemistry ry laboratory. complet mzdilla@t ed or in Michael J. Zdillaemple.edu progres s.

83 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Michael mshifman TUSM Shriners Epigenetics The goal of this research is to use the TU self-starter, Neurosc TBD Shifman @temple.e Hospitals regulation advantages of the lamprey CNS to test the Health good general ience du Pediatric of axonal hypothesis that “good regenerating” RS Science laboratory Research regeneratio neurons have higher levels of histone Campus skills Center n acetylation, favoring activation of a regeneration program, whereas histone deacetylation contributes to regeneration failure after SCI. Mohamm mkiani@te Enginee Mechanical Does low The effects of low and high doses of ionizing TU Some Biology, 12 Sophom ad Kiani mple.edu ring Engineering doses of radiation on human umbilical vein endothelial Main experience in Enginee hours ore,Junio ionizing cells will be determined using cell proliferation Campus any lab ring per r,senior radiation and comet assays. setting week (4 damage credits) DNA in HUVECs. TUSM Metastasis Markers Validation of genomic and gene expression TU None to one Biology TBD Sophom and for non- markers for differentiating human metastatic Health summer lab ore, Radiation metastatic and non-metastatic primary breast cancers. Science research Junior, Research human Inhibition of human glioblastoma tumors by Campus experience - Senior Lab breast betulinic acid combined with ionizing radiation Sincerity cancers in a nude mouse model. and inhibition achary@t of human Mohan Patnalaemple.edu Achary glioblastom a In Vivo.

84 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Mohsin tuf72052 TUSM Center for Human The goal of these studies is to develop a TU General Lab Biology 10 Junior or Khan @temple. Translationa Cardiac cardiac regeneration strategy based on human Health Skills Senior edu l Medicine stem cell cardiac stem cells isolated from heart failure Science and patients. Understanding the role of aging and Campus exosome disease onset will allow development of novel based strategies for enhancing human cardiac stem therapies ability to repair the heart after myocardial for cardiac damage. Students will work with regeneratio characterizing human cardiac stem cells by n fluorescence microscopy, immunoblot analysis, viral modification and cell proliferation/death assays. Students will be expected to work on these projects efficiently with inclusion of their name in a conference abstract or a publication depending on the level of their contribution. Murugana tud20497 Enginee Environmen Technology The Water and Environmental Technology TU environ 10-15 Sophom ndham @temple.e ring etal developme (WET) Center (funded by National Science Main mental hours a ore, Manickav du Engineering nt for Foundation and Industry), Department of Civil Campus science/ week Junior, achagam water and and Environmental Engineering, Temple enginee Senior wastewate University focused to address issues related to ring and r treatment water and wastewater. The primary research or related to (1) Physico-chemical water and Chemist wastewater treatment processes, 2) Analytical ry methods development for emerging backgro compounds, and 3) bio-chemical water and und wastewater treatment process.

85 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Nancy npleshko@ Enginee Bio- Developme A significant impediment to advances in TU Motivation, Bioengi 10-15 Sophom Pleshko temple.edu ring engineering nt of generating replacement tissues for damaged Main organization, neering hours ore, spectrosco cartilage is the inability to assess the structure Campus and ability to - per Junior, pic of an engineered tissue during growth. Near- work Introdu week Senior methods infrared spectroscopic assessment could offer productively ctory for the ability to monitor tissue growth in vitro, in a team Biology assessment and thus permit appropriate interventions to environment and of be undertaken on an ongoing basis to modify - Introductory Chemist engineered the tissue towards desired structural and Biology and ry tissues compositional endpoints. The research project Chemistry; will involve growing engineered cartilage Analytical or constructs on scaffold materials and Organic developing spectroscopic methods to monitor Chemistry tissue development. helpful Nancy npleshko@ Enginee Bio- Spectrosco Protein quantification is essential in a variety TU Motivation, Bioengi 10-15 Pleshko temple.edu ring engineering pic of life science applications. Frequently, Main organization, neering hours methods mixtures of proteins are separated using Campus and ability to - per for polyacrylamide gel electrophoresis (PAGE) work Introdu week detection followed by quantitative analysis. The productively ctory of protein quantification steps generally require addition in a team Biology separation of contrast agents, which may reduce the environment and by gel ability to isolate the intact protein from the - Introductory Chemist electropho gels, a process which is technically challenging. Biology and ry resis The ability to quantify separated proteins on Chemistry; PAGE gels without external contrast would Analytical or expedite protein analysis and facilitate Organic extraction of proteins from gels. The research Chemistry project will involve development of near helpful infrared spectroscopic imaging (NIRSI), a modality based on intrinsic contrast from molecular vibrations, as a novel method for non-destructive quantification of protein within electrophoresis gels.

86 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce TUSM Fels Genetics We are investigating differences between male Fels Basic Biology, TBD Junior Institute for and and female embryonic stem cells and the Institut laboratory Bioche Cancer Epigenetics mechanisms by which these early differences e for skills, such as mistry Research of sex- are established. Epigenetic assays will be Cancer pipetting and specific performed to detect the impact of sex on Researc making expression differentiation of the cells. h solutions noraengel patterns in required. @temple. early Nora Engel edu embryogen esis

87 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Nune nsarkiss@t TUSM Fox Chase Human Our group investigates effects of maternal TU TBD Darbinian- emple.edu Cancer Brain exposure to psychoactive medications and Health Sarkissian Center Developme alcohol during pregnancy on the fetal brain Science nt and development. Maternal alcohol (EtOH) Campus Exposure exposure can lead to significant neuronal loss, to synaptic dysfunction that can lead to Fetal Psychoactiv Alcohol Syndrome (FAS). Mechanisms of e neurotoxicity have been explored in animal Medication models and in vitro human models, but data s and from in vivo human models is scarce. Our Alcohol group developed unique in vivo human FAS model to investigate molecular mechanisms of massive neuronal and synaptic loss, and to identify neurological diseases-specific miRNAs that upon prenatal alcohol exposure can lead to Fetal Alcohol Syndrome, depression or Cerebral Palsy (CP). We also investigate molecular mechanisms in neuroprotection by human DING protein against alcohol-induced neuronal injury, using various advanced techniques, including RNA or miRNA studies by quantitative Real-Time RT-PCR; protein studies including quantitative western-blot assays and ELISA; fluorescence-based studies including FACS, Microscopy, and functional bioactivity assays.

88 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Nune nsarkiss@t TUSM Fox Chase Effects of Maternal alcohol (EtOH) exposure can lead to TU Advanced, Neurosc 10 to 15 Juniors & Darbinian- emple.edu Cancer Maternal significant neuronal loss, synaptic dysfunction Health motivated, ience, hours Seniors Sarkissian Center Alcohol and fetal alcohol syndrome (FAS). Mechanisms Science interested in Biology, per Consumpti of neurotoxicity have been explored in animal Campus research Pharma week on and models and in vitro human models, but data cy, Gestational from in vivo human models is scarce. Medical Age on , Human Psychiat Fetal Brain ry, Apoptosis Gynecol ogy

89 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce TUSM Medical Design of is to design novel The goal of this research TU GPA, Chemist 10 Sophom Genetics Novel liposomes for targeted drug delivery to treat Health research ry, ore, and Liposomes will use bipolar tetraether lipids cancers. We Science interest - Biology, Junior or Molecular for Drug polyethylene (BTL) as the matrix lipids and Campus Basic chem. and Senior Biochemistr Delivery glycol (PEG)-linked conventional lipids as the lab skills Physics y to make liposomes (100- minor component 200 nm in diameter) with entrapped BTL will be isolated from the .anticancer drugs thermoacidophilic archaea Sulfolobus acidocaldarius. Physical properties of these characterized BTL-based liposomes will be using a variety of biophysical techniques. Drug inhibitory effect of liposomal release and the drug against breast cancer cells will be monitored. These BTL-based liposomes are stability against expected to show remarkable temperature, pH gradient, mechanical stress, serum proteins, bile salts, and ,pressure enzymatic digestions; and, they can be tailored for targeted delivery and controllable to solid tumors. release of anticancer drugs This multidisciplinary research involves lipid purification, chemical ,microbe growth modification and characterization of archaeal lipids, fluorescence spectroscopy, microscopy, pchong02 cell biology calorimetry, and the usage of Parkson Lee-Gau@temple. techniques. The obtained results may lead to Chong edu liposomal drugs to treat new designs of .cancers with a higher efficacy

90 11/1/16 pchong02 TUSM Medical Novel Project 1: Archaeal bipolar tetraether TU having Chemist TBD @temple.e Genetics Membrane liposomes (BTL) are remarkably stable and Health passion in ry, du and s for robust biomaterials, holding great promise for Science science and Biology, Molecular Targeted technological applications. They can be used as Campus technology; Physics, Biochemistr Drug targeted carriers, slow-release drug carriers, eager to Bioengi y Delivery/Co biosensors, microbubbles for imaging and learn new neering ntrolled diagnosis, sterilized storage devices, and things; willing Release coating materials. The goals of this research to devote a and Other are: (1) to gain a deeper molecular significant Technologi understanding of the structure-activity amount of cal relationship of BTL liposomes in order to time to the Application improve their usage as biomaterials and lab work; - s Such As explore their possible new applications, and general Artificial (2) to design and fabricate liposomes (i) for chemistry-- Photosynth targeting phosphatidylserine- and required; esis phosphatidylethanolamine-rich areas in cells advanced and (ii) as thermosensitive liposomes for courses, controlled drug release. Project 2: The main including but objective of this research is to fabricate a not limited to highly efficient and durable, membrane-based organic artificial photosynthesis device using novel chemistry lipids and enzymes from thermoacidophiles. and physical The system would be capable of converting chemistry, sunlight, CO2 and water into carbohydrates for would be the production of biofuels such as ethanol. The helpful. -- innovation of this research lies in (i) the use of This is a archaeal bipolar tetraether lipids in the multidisciplin reconstitution of bacteriorhodopsin (BR)/ATP ary project, synthase into vesicle or planar membranes, particularly and (ii) a new design of micro fluidic devices to suitable for accommodate the new BR/ATP students who synthase/archaeal lipid photosynthesis system. plan to Reference: (1) Pattillo, et al. (2009) Radiation- attend Guided Targeting of Combretastatin graduate Encapsulated Immunoliposomes to Mammary school in the Parkson Lee-Gau Tumors. Pharmaceutical Research, 26, 1093- near future. Chong 1100. DOI: 10.1007/s11095-009-9826-1. (2) Samson et al. (2011) Molecular and Structural

91 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Basis of ESCRT-III Recruitment to Membranes during Archaeal Cell Division. Molecular Cell, 41, 186-196. DOI: 10.1016/j.molcel.2010.12.018. (3) Chong et al. (2012) On Physical Properties of Tetraether Lipid Membranes: Effects of Cyclopentane Rings. Archaea, vol. 2012, Article ID 138439, 11 pages. doi:10.1155/2012/138439. (4) Ren et al. (2014) Design, Fabrication and Characterization of Archaeal Tetraether Free- Standing Planar Membranes in a PDMS- and PCB-Based Fluidic Platform. ACS Applied Materials & Interfaces, 6, 12618-12628. DOI: 10.1021/am502613x CST CIS Testing an reasoning system that NARS is an intelligent TU Strong comput TBD Sophom intelligent accepts knowledge and problems in a formal Main interest in er and ore, reasoning and uses some inference rules to ,language Campus science, informa Junior or system derive new knowledge and to solve the especially in tion Senior problems (see online publications and demo). human and sciences various practical This system will be applied to machine , situations to test the expressive power of the intelligence; mathe the inferential power of the language and solid matics rules. Also under study will be the possibility background of using this logic to reason on structured in databases and the knowledge sources, such as mathematics .Semantic Web and computer science. - knowledge of formal logic, pei.wang probability @temple. theory, and Pei Wang edu computer programming

92 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Prasun dattapk@ TUSM Neuroscienc Cross-talk Elucidate mechanism(s) by which HIV-1 protein TU Willingness Biology, TBD Sophom Datta temple.ed e between Vpr modulates macrophage glucose Health to learn new Neurosc ore, u HIV-1 and metabolism. 2. Elucidate mechanism(s) by Science techniques. - ience, Junior or glucose which HIV-1 protein Tat modulates microglia Campus Prefer prior Bioche Senior metabolis and astrocyte glucose metabolism. experience in mistry m If significant progress is made by the student research. then he/she will be allowed to submit an abstract to a national meeting or submit a manuscript for publication as a contributing author. Prasun dattapk@t TUSM Neuroscienc Regulation Research focuses on determining the role of TU Selection Biology, TBD Sophom Datta emple.edu e of HIV-1, cytokines and drugs of abuse in the Health criteria are Neurosc ore, glutamate regulation of glutamate transporter expression Science good ience, Junior or transporter in astrocytes, microglia and macrophages. If Campus organizationa Bioche Senior EAAT2 in significant progress is made by the student l skills, mistry the context then he/she will be allowed to submit an interest in of abstract to a national meeting or submit a learning and NeuroAIDS manuscript for publication as a contributing hardworking. author. Prefer prior experience in research Qiang qzeng@te CST CIS New The latest generation of Intel processors Main Interest in CIS 10 to 15 Juniors Zeng mple.edu security provides new security features, which may Campus cyber or features of bring a revolution of systems and software security. Seniors the new security. We will analyze such new features Good Intel and consider the fancy applications. programming processors skills in C, C++, Java or Python.

93 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Qimin Yan qiminyan CST Physics Computati Layered two-dimensional (2D) materials, such Main Good Physics, 12 Seniors @temple. onal study as graphane and MoS2, have attracted a lot of Campus computation Materia edu of elastic attentions in the recent years for electronics al and ls properties and energy applications. These two- programming science of two- dimensional compounds have shown skills (Linux, dimensiona completely different elastic properties matlab, l materials compared with their bulk counterparts, which python), motivates the computational study in this responsible, proposal. The student will develop a finite- willing to element-analysis method combined with first- work hard. principles parameters to evaluate the deformation of single-layer 2D materials under a uni-axial stress. The derived force curve will be useful to analyze the results of atomic force microscope experiments. Qimin Yan qiminyan CST Physics Machine Machine learning technology has shown a Main Good Comput 12 Seniors @temple. learning great potential to learn from existing data and Campus programing er edu based on predict new properties in the area of materials skill with science, Hamiltonia science. In this proposal, the student will work python or physics, n for with experts in materials science and java, good material materials computer science to develop machine learning communicati s science models to recognize the similarity in different on skills, science application Hamiltonians, which is a quantum mechanics willing to s quantity to define a physical system, and work hard, correlated this similarity with the electronic responsible properties of materials. Qimin Yan qiminyan CST Physics Computati Artificial photosynthesis using complex oxides Main Programming Physics, 12 Seniors @temple. onal study poses a grand challenge for the generation of Campus skills, Python, Materia edu of renewable energy from sun light and water. Linux, good ls photocatal The student will carry out high-throughput communicati Science ytic water calculations and data-mining to search for on skills splitting on promising transition metal oxides for solar transition water splitting. metal oxides

94 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Rachel rachel.spi CST Biology Self The ability to self-pollinate may be adaptive Main Ability to Biology TBD Sophom Spigler gler@tem fertilization when pollinators are scarce, but we lack Campus follow ores and ple.edu and critical information on the extent to which directions. Juniors inbreeding plants rely on this ability and its consequences Exceptional are depression offspring viability. Students will help in attention to encourag in a native greenhouse and lab (PCR). detail. Basic ed to grassland lab skills apply. plant (work will involve DNA extraction and PCR under supervision). Completion of one semester of Chemistry and both Introductory Biology courses. Rachel rachel.spi CST Biology Floral trait Flowering plants display an amazing diversity Main Attention to Biology TBD Any Spigler gler@tem variation in of floral forms, with adaptations that enable Campus detail ple.edu a native them to attract pollinators and, in cases when Interest in biennial pollinators are scarce, self- pollinate. We biology plant, conducted a greenhouse study examining and/or plant Sabatia traits related to pollinator attraction and the sciences angularis ability to self-pollinate in a native biennial, Ability to Sabatia angularis. In the Spring, we will follow continue with this project and evaluate self- directions - pollen deposition and pollen tube growth BIOL 1111 rates. A majority of the work will involve microscope work.

95 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Rachel rachel.spi CST Biology Evaluating Habitat fragmentation and degradation due to TU enthusiastic, Biology, 10-12 Any Spigler gler@tem effects of human activities continue to occur at alarming Main hard- Natural hours a ple.edu habitat rates, threatening biodiversity and ecosystem Campus working, Science week fragmentat health. One of the first lines of defense in reliable, s ion on habitat conservation is ensuring that the plant attention to plant- populations that build the foundation of that detail, animal habitat remain intact and viable. Because interest in interaction plants are stationary and so many rely on ecology and s and their pollinators for successful reproduction evolution consequen presents them with particular challenges when ces for habitats are fragmented and degraded, floral trait including reduced pollinator and mate evolution availability. This past summer, we performed a series of studies in wild populations investigating how pollination conditions and floral traits vary across habitat fragments in order to understand how plants might rapidly adapt to face these new challenges. This Spring semester, will be continuing this project. Specific questions to be addressed by the URP project include: To what extent does reproductive success and offspring fitness vary across habitat fragments and in relation to population size and/or pollination conditions? The student will work in the lab and greenhouse. Opportunities to participate in fieldwork as well as molecular work (DNA extraction, PCR, genotyping) are available as well.

96 11/1/16 Raza Zaidi zaidi@tem TUSM Fels molecular Melanoma is the deadliest type of skin cancer, TU Highly Bioche TBD ple.edu Institute for mechanism which originates from the pigment (melanin)- Health motivated misry or Cancer s of producing cells (melanocytes) in the skin. Science individuals Biology Research Melanoma Approximately 85% of melanomas are directly Campus who have the genesis caused by the UV radiation from the sun and passion for artificial tanning beds. However, the molecular molecular mechanisms of this cause-and-effect biology relationship remain largely undefined. We are research, and using cell culture and mouse models, and are willing to cutting-edge molecular biological techniques, commit genomics, and epigenomics to tease out the themselves molecular mechanisms of UV-induced to a steep melanomagenesis. learning curve, dedication, and hard work. Prerequisites: Intro Biology I+II+Lab; General Chemistry I+II+Lab; Calculus I; and either Genetics and/or Gen Biochemistry. Minimum GPA 3.25, 3.5+ desirable. Must be willing to work with mice as well as mouse and human

97 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce cancer cell lines. Richard souvenir@t CST CIS Identifying The student will apply and adapt recent TU Strong CS TBD Souvenir emple.edu Indoor techniques from computer vision and machine Main programming Scene learning to identify attributes from images of Campus skills Attributes indoor scenes. This work is part of an ongoing (preferably from project to (http://traffickcam.org/about) to Python), Images combat human trafficking by identifying hotel interest or room features from images. experience in image processing Courses taken CIS 3223 - Strong programming skills (preferably Python), interest or experience in image processing

98 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Richard T. richard.po TUSM Fels How the Genome instability in the form of chromosome TU Intelligent, Bioche TBD Pomerant merantz@t Institute for process of breaks, rearrangements and deletions is a Health hard- mistry, z emple.edu Cancer transcriptio hallmark of cancer cells and contributes to Science working, Biology, Research n tumorigenesis. The research project aims to Campus independent, or contributes understand how the process of transcription passionate Chemist to genome contributes to genome instability in human about science ry instability cells. Current research in the lab reveals a and research. in human direct link between transcription and DNA - General cells. deletions and rearrangements in human Biology, cancer cells. This suggests that transcription perhaps plays a much larger role in promoting genome Chemistry -- instability and potentially cancer than Successful previously thought. The goal of the project is summer to analyze and annotate the sequences of DNA research is deletions and rearrangements generated at likely to be transcription sites in human cells. The results published in of this research is likely to provide new peer important insight into how the fundamental reviewed process of transcription can cause genome journals. instability and will likely be published in a high profile journal.

99 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Richard T. richard.po TUSM Fels This A newly discovered DNA repair process called TU Intelligent, Bioche TBD Pomerant merantz@t Institute for research alternative end-joining (alt-EJ) or Health hard- mistry, z emple.edu Cancer will provide microhomlogy-mediated end-joining causes Science working, Biology, Research important chromosome deletions and rearrangements Campus independent, or insight into and promotes the survival of breast and passionate Chemist how ovarian cancer cells. Current research in the about science ry polymerase lab has reconstituted the process of alt-EJ in and research. theta vitro and has elucidated how a key protein in - General functions this pathway, DNA polymerase theta, Biology, during alt- generates insertion mutations at DNA repair perhaps EJ and junctions. The goal of the project is to analyze Chemistry -- promotes and annotate the sequences of insertion Successful the survival mutations generated by polymerase theta summer of cancer during alt-EJ in vitro. This research will provide research is cells and important insight into how polymerase theta likely to be chemother functions during alt-EJ and promotes the published in apy survival of cancer cells and chemotherapy peer resistance resistance and will likely be published in a reviewed and will reputable journal. journals. likely be published in a reputable journal.

Rob robkulathin CST Biology Genomics Is speciation driven by genes involved in TU Determinatio Biology, 10 Sophom Kulathinal al@temple. of reproduction? In this project, the student will: Main n, curiosity, Comput ore edu speciation 1) identify genes under selection using Campus and er evolutionary genomic approaches and/or 2) computation Science knock-down those genes using ready-made ally-inclined RNAi lines via our high-throughput behavioral arenas. The student will be trained by an active team of undergraduate and doctoral students who are already applying these powerful approaches using Drosophila.

100 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Robert J. rjlevis@te CST Chemistry Stand-Off The ability to detect molecules at distances up TU independent Neurosc TBD Sophom Levis mple.edu Detection to 50 meters is valuable for many applications Main motivation ience, ore, of including explosives detection, analyzing Campus Cell and Junior, Molecules smoke stacks and probing urban Develop Senior using environments. This project will involve working mental Advanced with femtosecond laser filamentation ("a light Biology Laser saber") and a new Raman spectroscopy Technology method developed in the Center for Advanced Photonics Research. Interested students should read the publications on the Center's web site at www.temple.edu/CAPR for additional information. Robert J. rjlevis@te CST Chemistry Nanomater Nanomaterials include size as a design TU independent Neurosc TBD Sophom Levis mple.edu ials by parameter for a material’s properties. For Main motivation ience, ore, Design instance the color of a quantum dot changes Campus Cell and Junior, as the size changes from 100nm to 10nm. The Develop Senior aim of this project is to discover new mental nanomaterials using femtosecond laser Biology processing of precursors including chemical compounds, bulk metals, semiconductors and organic materials. The project involves the use of lasers and state of the art optics as well as characterization methods including UV-VIS, mass spectrometry, transmission electron microscopy, dynamic light scattering and a nanoparticle size analyzer. Robert robert.sand CST Biology Mixotrophi Algae that ingest particles in addition to TU Interest in Biology, approxi Sanders ers@templ c photosynthesisng (mixotrophs) are now known Main aquatic Environ mately e.edu microalgae to frequently dominate phytoplankton Campus ecology. mental 10 and climate throughout the world's oceans and lakes. We Biology 1111 Science change are using cultures of Arctic mixotrophs to or 1911. investigate how factors related to climate change will affect the balance of feeding and photosynthesis in their nutrition.

101 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce CST Chemistry Chemical Chemical biology approaches to the TU Having Chemist TBD Sophom probes to mechanism study, diagnosis, and treatment of Main completed ry, ore, study post- human diseases Campus General Biology, Junior, or translation II. Chemical proteomics to identify key Chemistry, Bioche Senior al proteins for the onset of cancer and Organic mistry, modificatio inflammatory disorders. Chemistry I Pharma ns with a grade ceutical of B or higher. Preferably with prior laboratory rosswang experience in @temple. Chemistry Ross Wang edu and Biochemistry

Ross rosswang CST Chemistry Developme Chemical biology approaches to the TU Having Chemist TBD Sophom Wang @temple. nt of novel mechanism study, diagnosis, and treatment of Main completed ry, ore, edu imaging human diseases Campus General Biology, Junior, or agents for Chemistry, Bioche Senior image- Organic mistry, guided Chemistry I Pharma cancer with a grade ceutical therapy of B or higher. Preferably with prior laboratory experience in Chemistry and Biochemistry

102 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Ross rosswang CST Chemistry Design and Chemical biology approaches to the TU Having Chemist TBD Sophom Wang @temple. synthesis mechanism study, diagnosis, and treatment of Main completed ry, ore, edu of antibody human diseases Campus General Biology, Junior, or mimics Chemistry, Bioche Senior Organic mistry, Chemistry I Pharma with a grade ceutical of B or higher. Preferably with prior laboratory experience in Chemistry and Biochemistry Sara Jane saraward@ TUSM CSAR Cannabinoi Research focuses on determining the role of TU Interest in Neurosc TBD Junior or Ward temple.edu ds, inflammation across a range of CNS disorders, Health neuroscience ience, Senior Inflammati from stroke to substance abuse. We take a Science /experimenta Psychol on, and behavioral and molecular immunological Campus l psychology ogy CNS Injury approach to studying the role of inflammation in CNS disorders and testing the hypothesis that cannabinoid based-treatments have a potential to reduce this inflammation and therefore improve behavioral outcomes.

103 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce CST Chemistry Two possible projects: "Evaluation of IL-8 TU Having Chemist TBD Sophom Two inhibitors for inhibition of cancer metastasis" Main completed ry ore, possible and "Development of novel cyclic ether Campus both Organic Junior, projects: synthesis from tertiary alcohols" 1 and Organic Senior "Evaluation 2 with a B or higher in of IL-8 both courses. inhibitors Strong letter for of inhibition recommenda of cancer tion from metastasis" with organic and professor. "Developm ent of novel cyclic ether synthesis from tuf76212@ tertiary Sarah Wengryniuktemple.edu alcohols"

Scott scott.sieb CST Chemistry Simple Using light to drive cycloaddition reactions and TU main work hard, science TBD Freshma Sieburth urth@tem Methods make strained, reactive new structures. campus work smart. n ple.edu for Complex Molecules

104 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Seo-Hee seo.hee.c TUSM Shriners Examining This project consists of three parts. First, TU Biology TBD Sophom Cho ho@templ Hospitals the effects construction of AAV-Yap (WT), AAV-YapS1A Health ore e.edu Pediatric of Yap WT and AAV-YapS1D via recombinant DNA Science Research and Yap technology. Second, expression of Yap, WT Campus Center/ mutant and mutant, genes in the neonatal retina by Anatomy genes electroporation or viral injection. Lastly, and Cell overexpres characterization of resulting retinas with Biology sion in the various analysis tools including developing immunofluorescennce assay followed by retina microscopic imaging. using AAV (Adeno- associated virus) vectors.

105 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Seo-Hee seo.hee.ch TUSM Shriners (1) A new Our research focuses on understanding the TU not required Biology TBD any Cho o@temple. Hospitals LCA model cellular and molecular mechanisms underlying Health related edu Pediatric by polarity the normal development and degenerative Science - Research gene diseases of the mammalian retina. Topics we Campus General Center/ ablation (2) currently study include: (I) Functional analysis Biology Anatomy Genetic of apical polarity gene Pals1 during retinal recomm and Cell analysis of development. (II) Pathophysiology study of ended Biology the degenerative retinal diseases (LCA and RP) to signaligng understand the underlying disease causing genes mechanisms. We are particularly interested in during eye polarity defect in retinal progenitor cells, developme which causes early-onset, photoreceptor nt degeneration in Leber Congenital Amaurosis 8 (LCA 8) and/or late-onset Retinitis Pigmentosa 12 (RP12). (III) Cell-transplantation and gene- based therapies: Our goal is to customize therapy strategies using cell- and gene-based approaches to restore vision loss in LCA8-like mouse model in preclinical settings. (IV) Investigating the function of tumor suppressor genes, TSC2 and Hippo-Yap signal transduction pathway components, in the eye development.

106 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Seonhee tue62079 TUSM Anatomy The role of My laboratory’s research focuses is to TU Biology 10 to 15 Junior or Kim @temple. and Cell cell understand the molecular and cellular Health Senior edu Biology signaling mechanisms controlling brain development to Science and study the basis of neurodevelopmental Campus polarity in disorders. To gain in-depth knowledge of neural neural development and neuronal disorders, developme we utilize multidisciplinary approaches such as nt molecular and neuroanatomical techniques including gene cloning, progenitor or neuronal culture, cortical electroporation and time- lapse imaging of cortical explants. Students will involve the characterization of animal models exhibiting abnormal cortical or cerebellar development and gene cloning projects to clone the genes that are critical for regulation of proliferation and differentiation during neurogenesis. Sergei spond@te CST iGEM and Software Utilize and develop open-source software to Main Comput 10 any Pond mple.edu Biology developme explore DNA mutations. Please see Campus er hours or nt and www.hyphy.org and github.com/veg/hyphy for Science, more Bioinforma more information. Using high-performance Mathe tics computing, statistical techniques, and the matics, latest web technologies, we provide methods Biology, that researchers use to answer questions Physics about their genetic sequence data. All computational development and research takes place within iGEM located in the SERC building (igem.temple.edu).

107 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Shumo shumo.cui CST Mathematic Analyzing How annoying is it when traffic comes to an Main Good Mathe TBD Junior, Cui @temple. s phantom inexplicable stop for no apparent reason Campus programming matics, Senior edu traffic jams before starting right back up? In fact, besides skills Comput the psychological consequence, those so- er called phantom traffic jams also contribute to Science increased fuel consumption, vehicle emissions, accidents and delay. Using the novel mathematical models and simulation tools, we will investigate and analyze the interaction of phantom traffic jams and their stability. The results of this research will enable researchers to improve the ability of mathematical models to describe the real traffic.

108 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Shuxin Li shuxin.li@t TUSM Shriners Neural Our lab is highly interested in neural repair and TU Motivated TBD emple.edu Hospitals repair and CNS axon regeneration research. Our projects Health person and Pediatric CNS focus on the molecular/cellular mechanisms Science basic Research neuronal for CNS neuronal growth failure and Campus background Center regeneratio development of novel and effective strategies on research. n to promote neuronal regeneration, remyelination and functional recovery after injury and/or in neurodegenerative disorders. We employ various in vitro and in vivo research approaches, including molecular/cellular neurobiology, biochemistry, genetic and pharmacological methods, transgenic over-expression and knockout mice and multiple neuronal/axonal lesion models (such as spinal cord injury, optic nerve crush and EAE) in mice and rats. We have produced a number of high impact papers related to CNS axon regeneration and treatments for CNS injury. Our lab is nationally and internationally recognized for discovering that the leukocyte common antigen related phosphatase (LAR) is a receptor for CSPGs and for promoting CNS axon regeneration with available clinical drugs that suppress Rho and GSK-3 signaling pathways.

109 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Slobodan vucetic@te CST CIS Data Scientific and technological advances have TU Some Any CST TBD Vucetic mple.edu Science allowed us to collect massive amounts of Main programming major diverse types of data. There is an increasing Campus experience, might recognition that data created by scientists, good math find this mobile apps, internet, social media, background - project crowdsourcing, healthcare could be translated Programming valuable into valuable insights. A data scientist is a in any person who has the skills, knowledge, and language ability to extract actionable knowledge from (Python, Java, the data -- either for the good of society, C, Matlab) advancement of science, or profit in business. Calculus 1 This project will be custom-made to suit the background and interest of a student and give an opportunity to get an expertise in all aspects of data science including collecting, accessing, and processing large and complex data, applying methods from machine learning and statistics to analyze data, and presenting the data and analytic insights through modern visualization techniques.

110 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce CST Chemistry Studying light play an important Processes initiated by TU Students Chemist TBD Junior or the role in biological systems with primary Main should be ry, Senior photophysi found in photosynthesis, vision, and examples Campus motivated, Physics cs and A .DNA photochemical damage and repair in interested in photochem these processes fundamental understanding of research and istry of works and also reveals the way nature computation DNA using provides ideas on how to mimic or alter these al work, with quantum The current .our own benefit mechanisms to an aptitude mechanics studies of the focuses on project for math. photophysical behavior of DNA bases and their When UV radiation is .fluorescent analogs photochemical reactions ,absorbed by DNA may occur which can lead to photochemical DNA, however, is proven to be quite .damage can photostable, since the absorbed energy be converted to harmless heat. We examine what happens after one or two bases absorb fundamental mechanism light, and what is the for making these molecules photostable. We mechanics to study these use quantum processes. Large scale computations are solve the Schroedinger equation to employed approximately, and the results are analyzed to structure, properties provide the electronic and reactivity of the molecules studied. Apart smatsika quantitative answers we also obtain from @temple. orbitals and qualitative pictures by visualizing Spiridoula Matsikaedu other properties, which give us physical .insight

111 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Stefania gallucci@te TUSM Microbiolog Regulation The project includes studies of cellular TU Strong Biology TBD Gallucci mple.edu y- of Type I immunology and molecular biology of signal Health motivation to _Preme Immunology Interferons transduction of cytokines involved in the Science learn and d in pathogenesis of an autoimmune disease, Campus hard working. Autoimmu Systemic Lupus Erythematosus. The goal of the nity project is to test novel biologics to be used in the therapy of autoimmune diseases. CST Chemistry Nanopartil Nanoparticles have high surface/volume ratios TU Willingness Chemist TBD Junior or e/Lipid so that characterization of the material on the Main to work hard, ry, Senior Project surface is very important in applications such Campus understandin Bioche as drug/DNA delivery and nanocomposites. g of m - The phase transitions, conformations and experimental organic adsorption isotherms of lipids and polymers techniques chemist (both natural- proteins, DNA, RNA and and the ry I, synthetic-polymers) on silica nanoparticles of importance analytic different sizes (from 5-500nm) will be of obtaining al slwunder investigated by a variety of analytical reproducible chemist @temple. techniques such as HPLC, FTIR, Raman and data - wet ry Stephanie Wunderedu fluorescence spectroscopies, and thermal chemistry analysis. techniques

112 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce CST Chemistry Lithium In order to improve the performance of TU Willingness Chemist TBD Junior or Batteries & lithium ion batteries and fuel cells, it is critical Main to work hard, ry, Senior Fuel Cells: to make advances in many aspects of the Campus understandin Bioche Materials materials used in the electrodes, electrolytes g of m - preparatio and separators. This project involves preparing experimental organic n & and characterizing novel nanomaterials to be techniques chemist Characteriz employed as separators for NaBH4 fuel cells and the ry I, ation and lithium ion batteries. In particular we have importance analytic functionalized what are called polyoctahedral of obtaining al silsesquioxanes (POSS), which are nano silica reproducible chemist (SiO1.5) cubes with eight groups at the corners data - wet ry that contain dissociable Li+, OH- ions or chemistry polyethylene glycol. The project(s) involve techniques slwunder incorporation of these POSS materials with @temple. polymers, and the characterization of the Stephanie Wunderedu nanocomposites by calorimetric and electrochemical methods.

Steven srhouser@ TUSM Cariology Role of We are studying role of cortical bone derived TU General lab Biology Minimu Junior or Houser temple.edu Cortical stem cells (CBSCs) in repair of heart after Health skills or m 12 Senior bone cardiac injury. We have previously shown that Science Chemist hours a derived these stem cells have capacity to improve Campus ry week stem cells heart function mainly by secreting cardio for protective factors and mediating cardiac repair improving by differentiation into cardiac lineages. heart Currently, we are testing this hypothesis in a function larger animal model for clinical relevance of after CBSCs. Concurrently, we are focused on myocardial investigating if these beneficial effects can be infarction achieved by transfer of small vesicles called exosomes from these cells.

113 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce s.kumar@t CST iGEM and Software We develop software (including smartphone TU Knowledge of All 10 Freshma emple.edu Biology developme apps) for analyzing biological data in the fields Main computer majors hours or n, nt and of Genomics and Medicine. See Campus programming more Sophom Bioinforma www.megasoftware.net and and/or app ore, tics www.kumarlab.net for examples. All development Junior Sudhir Kumar developments will be in a new institute in SERC (igem.temple.edu).

CST iGEM and We all have many DNA differences from TU Interest in All 10 Freshma Biology Personalize others. Which of these personal differences Main the field, majors hours or n, d medicine cause disease? We use computers to study Campus knowledge of more Sophom and disease variation in humans and compare it to computers ore, evolutionar differences humans show with other species. Junior We also build predictive methods and tools. All y link computational research will be in a new between institute in SERC (igem.temple.edu). See s.kumar@t DNA and www.kumarlab.net for publications. Sudhir Kumaremple.edu disease

Sudhir s.kumar@t CST iGEM and Genomics, Students will carry out biological and TU Freshmen Biology, TBD Kumar emple.edu Biology Medicine, biomedical research using computers with Main and Comput and emphasis on DNA data analysis. Biomedical Campus sophomores ers, Evolution questions will be focused on Genome with interest Physics, (computer Medicine. Biological questions will be on in biology, Anthrop based) building the tree of life. Depending on the medicine, or ology, student's background, you may conduct computers. Pharma primary data analysis research and/or assist in No cy, developing new methods, software, and requirements Chemist databases. See igem.temple.edu and , as the ry www.kumarlab.net projects will be tailored to the students' level of preparation.

114 11/1/16 Sudhir s.kumar@t CST Institute for Genomic Evolutionary analytics of mutations, genomes, TU Prefer Biology, TBD Kumar emple.edu Genomics Medicine and species is the primary focus of my Main freshmen or Comput and and Tree of research group. We use integrative and Campus sophomores er Evolutionary Life comparative approaches to make fundamental interested in Science, Medicine discoveries in the fields of medicine, evolution devoting Chemist and genomics. The common theme of all our multiple ry, research is the use of comparative analysis to years working Physics, reveal genome differences that are outcomes in our group Biomedi of natural selection on novel mutations arising so they can cal in all species during their propagation from carry out real enginee generation to generation and in an individual’s research and ring, lifetime. The resulting patterns of conservation development and and divergence of our DNA enables us to projects, other conduct research investigations ranging from including the biology- establishing the tree of life scaled to time writing of related (TimeTree of Life) and to forecasting disruptive research depart mutations found in personal germline and papers ment somatic genomes (Phylomedicine). In these and/or pursuits of biological discoveries, we are also development developing new statistical methods and of software computer algorithms to quickly analyze large- and database scale datasets in these disciplines. We also tools. develop and disseminate many high-impact Successful software tools (MEGA and myPEG) and students will databases/applications (TimeTree and be provided FlyExpress). See www.kumarlab.net for a list of year-long papers and igem.temple.edu for our new wage-payroll institute website. positions to pursue research. Interest in doing computer- based research; no wet-lab or field work. -- Have a look

115 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce at our website igem.temple. edu and see how Temple is becoming a leader in genomics. sravi@tem CST Earth & Belowgrou Belowground processes such as root dynamics TU interest in Biology, TBD ple.edu Environmen nd can alter nutrient and water cycles and impact Main the Comput tal Sciences responses the response of terrestrial ecosystems to Campus project/resea er to climate changing climate and disturbance regimes. rch, critical science, change: Despite the relevance of belowground thinking, Environ Root processes, studies addressing the response of quantitative mental imaging fine roots to changing environmental ability - Basic Science and conditions are rare, mostly due to the statistics, s analysis difficulties in quantifying root dynamics interest in (production, growth and longevity) by non- image destructive methods. This project will processing, investigate the belowground responses of mostly plants to simulated changes in climate, in computer- particular warming and droughts. We will based project analyze a time series of below ground (root) images from a simulated climate change experiment (combination of warming and drought), collected using the unique minirhizotron root imaging system. This technique will enable us to observe root growth over time and trace single roots in the course of their development. The methods involve computer-based image analysis using the open source software application – Rootfly – and statistical techniques for simultaneous Sujith Ravi calculation of fine root production, length, mortality and turnover.

116 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Tasuku tasuku.aki TUSM Dermatolog Brain TBD Akiyama yama@te y and Processing mple.edu Anatomy & of Itch Cell Biology Thomas E tuc72715@ TUSM Cardiovascul Therapeuti Novel therapies are needed to improve cardiac TU Biology, Hours Junior or Sharp temple.edu ar Research c Potential function after MI; one strategy is to replace Health Chemist to meet Senior of Cell lost myocardium. Despite the success of bone Science ry, credit Based marrow- and cardiac- stem cell clinical trials, Campus Bioche require Therapy in we’re still searching for the optimal stem cell mistry, ments - the Swine type most suitable for preservation of existing Neurosc can be Heart after myocardium and cardiac regeneration. ience up to 20 Myocardial Previously, we described a novel cell if Infarction population derived from the cortical bone student (CBSCs) which repaired the heart post MI via wants transdifferentiation and paracrine signaling mechanisms in a mouse model. In the present study, we evaluate the translational potential of CBSCs in swine post MI.

117 11/1/16 TUSM Microbbiolo Personalize Leukemia stem cells (LSCs), and especially TU biology TBD Junior & gy and d quiescent LSCs, have a dual role as tumor Health Senior Immunology medicine- initiating and therapy-refractory cells. Science , Fels Cancer guided Currently available anti-tumor treatments Campus Research synthetic clear a disease burden consisting mostly of lethality to leukemia progenitor cells (LPCs), but they eradicate usually fail to eradicate drug-refractory tumor cells quiescent LSCs and drug-resistant proliferating LSCs/LPCs. Altered DNA repair mechanisms were suggested to be responsible for stimulation of survival of LSCs and/or LPCs under genotoxic stress. DNA double-strand breaks (DSBs), the most lethal DNA lesions, are repaired by two major mechanisms, homologous recombination (HR) and non-homologous end-joining (NHEJ). BRCA -mediated HR (B-HR) and DNA-PK –mediated NHEJ (D-NHEJ) repair DSBs in proliferating cells and D-NHEJ plays a major role in quiescent cells. PARP1-dependent NHEJ (P-NHEJ) and RAD52-dependent HR (R-HR) serve as back- ups/alternative mechanisms in proliferating and/or quiescent cells. The existence of these pathways creates the opportunity to apply “synthetic lethality” triggered by PARP1 and/or RAD52 inhibitors (PARP1i and RAD52i, respectively) in DNA-PK – deficient therapy-refractory quiescent LSCs and BRCA-deficient therapy-resistant proliferating LSCs/LPCs. We propose to test the hypothesis that Gene Expression (qRT-PCR, flow cytometry) and Mutation (specific oncogene expression) Analysis (GEMA) can identify individual patients with acute myeloid leukemia (AML) or tskorski@t acute lymphoblastic leukemia (ALL) which Tomasz Skorskiemple.edu quiescent and proliferating LSCs/LPCS will be sensitive to “dual cellular synthetic lethality”

118 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce triggered by PARP1i combined with standard drugs. In addition, unexpected oncogenic mutations causing BRCA/DNA-PK deficiency will be determined by CRISPR/Cas technology. We will test the hypothesis that PARP1i when combined with RAD52i triggers “dual molecular synthetic lethality” more efficiently eradicating LSCs/LPCs from BRCA/DNA-PK deficient AMLs/ALLs. We expect that PARP1i and/or RAD52i alone or combined with standard drugs will eradicate BRCA/DNA-PK deficient AML/ALL LSCs/LPCs in individual patients identified by GEMA. This project will provide foundation for precision medicine-guided synthetic lethality in AML/ALL patients. Tonia sthsieh@te CST Biology Control TU Biology TBD Hsich mple.edu mechanism Main s for Campus counting unexpecte d perturbatio ns during bipedal running in lizards

119 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Tracy tracy.fische TUSM Neuroscienc Role of While the brain is often considered to be TU Mature, Biology, TBD Sophom Fischer- r- e systemic "protected" from the body (periphery), in Health serious- Bioche ore, Smith smith@te immune reality, there is continued communication Science minded, mistry Junior, mple.edu alterations between the CNS and periphery. Under Campus responsible, Senior in the healthy conditions, this can aid the CNS, reliable developme however, it may have deleterious effects to nt of CNS the CNS in some disease states, as well as disease aging. We are exploring the role of altered systemic immunity in the promotion of CNS injury in HIV infection. Our previous work suggests that in HIV infection, immune polarization in the peripheral blood and the brain is associated with, and likely contributes to, AIDS progression and cognitive impairment. Our current studies focus on an expanded monocyte subset in HIV infection and explores the mechanisms for the observed expansion, as well as how this subset may contribute to disease progression and CNS decline. We anticipate this work will reveal important insights into immune polarization and disease pathogenesis, as well as help identify targets for potential therapeutic intervention. Vincent voelz@tem CST Chemistry Molecular This work involves computational modeling of TU Some Math, TBD Sophom Voelz ple.edu simulation proteins and peptide mimics. We simulating Main combination physics, ore or of proteins the molecular dynamics of molecules on high- Campus of comput Junior and performace computing platforms, to make programming er peptide predictions about folding and binding. experience, science mimics math skills and and physics chemist knowledge ry are important

120 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Weidong weidong.y CST Biology Super- Super-resolution light microscopy won the Main Biology, TBD Juniors Yang ang@tem resolution Nobel Prize in Chemistry in 2014. In our lab, Campus bioche and ple.edu study of we combine super-resolution microscopy with mistry, seniors interaction single-molecule tracking, fluorescence biophysi s and recovery and innovative molecular biology cs and competitio techniques to study the following projects: 1) the ns in interactions between human cells (normal and relevant normal and cancer cells) and viruses. 2) trafficking of RNAs, cancer cells vesicles and proteins through the nuclear pore complexes in live human cells. 3) the gating mechanism for macromolecules transport into the cilium of human cells.

121 11/1/16 Wenzhe wenzheho TUSM Pathology Exoosme in The proposed studies will reveal previous TU Prefer to Biology, TBD Ho @temple.e and Methamph unidentified mechanisms by which METH Health have Neurosc du Laboratory etamine and/or HIV compromise the BBB innate Science students with ience Medicine and HIV- immunity, providing a favorable micro- Campus biology associated environment for HIV neuroinvasion. major, having Neurodege a great neration interest in research (with or without experience, although research experience is preferred). Students should have attributes of paying attention to details, being a good listener, following instructions, getting along with others, and having ability to organize/pres ent data. Students also have excellent communicati on skill, and are able to read and

122 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce write in English. CST Chemistry The important role in bacterial c-di-GMP plays an TU Grades - Chemist TBD Sophom Synthesis lifestyles as a second messenger molecule. The Main Completed ry, ore, of c-di- compound controls many important life Campus Organic Bioche Junior or GMP ,processes including biofilm formation Chemistry mistry - Senior Analogs The .virulence, and cell-cell communication and Organic CHEM goal of this project is twofold - (1) to Chemistry 2201, molecule to act as synthesize analogs of the Laboratory 2202, chemical probes for the identification of c-di- 2203, and (2) construct non- GMP targets and/or hydrolyzable analogs to lengthen the chemical 2204 wwuest@t in vivo. The student will utilize lifespan William Wuestemple.edu techniques from organic synthesis and characterize compounds

William wwuest@t CST Chemistry Synthesis Bacteria form complex communities known as TU Grades and Bioche During Wuest emple.edu of Natural biofilms to protect themselves from Main research mistry, Semest Product- environmental stresses like antibiotics proving Campus interest Chemist er - 12- Inspired troublesome to multiple factions of society. ry, 15; Molecules Biofilms affect human health (infections, Neurosc During to Perturb dental plaque) and commercial interests (oil ience Summe Bacterial industry, water purification, shipping, r - 40 Biofilms residential) culminating in over $60M in costs and over 100,000 deaths , therefore, any discoveries that inhibit or kill these communities would be of great interest to society. Students will perform interdisciplenary research combining synthetic organic chemistry, biochemistry, and microbiology in an effort to thwart bacterial biofilms.

123 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Won H. whs@temp Enginee Bio- Live-cell Water soluble polymers will be utilized to TU Having taken Chemist TBD Sophom Suh le.edu ring engineering microscopy make three-dimensionally structured Main chemistry ry and ore, and hydrogels. Mammalian cells such as PC12 and Campus and biology Biology Junior or biocompati A549 will be encapsulated and their courses (with - One or Senior bility study biocompatibility will be quantified via live-cell lab) as a pair more of microscopy (and biochemical) methodologies. (at least) will basic mammalia help the (general n cells student (but ) inside 3D it is not a pre- chemist hydrogels requisite) ry course or one or more basic biology course Enginee Bio- Synthesis Three-dimensional microenvironment TU Having taken Chemist TBD Sophom ring engineering of conditions ideal for sustaining mammalian cell Main chemistry ry and ore, biocompati cultures will be developed via the conjugation Campus and biology Biology Junior or ble photo- of cross-linkable organic functional groups and courses (with - One or Senior or ionically- peptides on naturally occurring polymers such lab) as a pair more crosslinked as alginate, hyaluronan, and gelatin. (at least) will basic 3D Biochemical assays for cell viability will be help the (general hydrogels utilized to assess biocompatibility. student (but ) it is not a pre- chemist requisite) ry course or one or more whs@temp basic Won H. Suh le.edu biology course

124 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Enginee Bio- The Thermoplastics (e.g., polylactic acid) or TU Having taken Chemist TBD Sophom ring engineering biological photocrosslinkable polymer precursors (e.g., Main chemistry ry and ore, properties vinyl polymer) will be 3D-printed on two- Campus and biology Biology Junior or of 3D dimensional surfaces or inside three- courses (with - One or Senior printed dimensional structures. The 3D designs will be lab) as a pair more polymers rendered via CAD software and printed using a (at least) will basic standard 3D printer. Testing of biological help the (general properties will focus on cell viability and cell student (but ) adhesion. it is not a pre- chemist requisite) ry course or one or more whs@temp basic Won H. Suh le.edu biology course

Won H. whs@temp Enginee Bio- Synthesis Bioactive and/or cell penetrating peptide TU Having taken Chemist TBD Sophom Suh le.edu ring engineering of cell sequences will be synthesized via solid-phase Main chemistry ry and ore, penetrating peptide synthesis (SPPS) methods. Campus and biology Biology Junior or and Characterization will be performed via NMR courses (with - One or Senior bioactive and Mass Spectrometry methods after lab) as a pair more peptides separation of molecules via HPLC (High- (at least) will basic for drug Performance Liquid Chromatography). help the (general delivery Depending on the success of the peptide student (but ) synthesis, live-cell experiments will be it is not a pre- chemist conducted to test the peptide's bioactivity. requisite) ry course or one or more basic biology course

125 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Xiao-feng xfyang@te TUSM Pharmacolo Regulation Dr. Xiaofeng Yang’s laboratory, located in the TU Cardiov 10 or Yang mple.edu gy of vascular MERB-10th floor-1083, Centers of Metabolic Health ascular more inflammati Disease Research, Cardiovascular Research, Science Researc on and Thrombosis Research and Departments of Campus h atheroscler Pharmacology and Immunology, focuses on Center osis studying the regulatory mechanisms of vascular endothelial cell, smooth muscle cell, monocyte, adipocyte and regulatory T cell immune responses related to vascular inflammation and atherosclerosis. Atherosclerosis is a chronic autoimmune inflammatory disease characterized by intense immunological activity, and is the main cause of ischemic stroke and cardiovascular disease. Cardiovascular diseases and stroke remain as the leading cause of morbidity and mortality in industrialized society. There is increasing evidence that vascular endothelial cell inflammation significantly contributes to the onset and early development of atherosclerosis. Success of these projects will provide new molecular targets for future development of new therapeutics to treat cardiovascular diseases and stroke. Research projects in Dr. Yang’s lab are to determine how immune cytokine pathways regulate high lipid- and high glucose-triggered endothelial cell activation and inflammation, which include hyperlipidemia-, hyperglycemia-, uremia-, endotoxemia-induced endothelial activation, endothelial progenitor cell survival pathways, epigenetic regulation of regulatory T cell apoptosis, microRNA regulation of endothelial cell activation.

126 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce dux@templ CST CIS Mobile one of today's Mobile cloud computing is TU Good CS/IST/ 10 or Sophom e.edu cloud hottest new technology markets. In mobile Main programming Math- more ore, computing. users lease ,cloud computing Campus skills - High CS Junior or computing/storage services from cloud service GPA -Solid majors Senior access the cloud from their providers, and math mobile devices (smart phones, tablets). background - predicts that mobile cloud )2011( Gartner Good US$9.5 computing will reach a market value of communicati billion by 2014. Mobile cloud computing on skills - the notion that shares with cloud computing Team some level of service is provided by a cloud but working skills mobile platforms. Typical mobile accessed by cloud computing platforms include smart phones and tablets. The most-used mobile variations such as operating systems are UNIX Google Android and Apple iOS. Tablets are smart phone but interact with larger than a the user in a similar way, using a touch screen as the primary input device. As of October the Apple 2011, the top-selling tablets are Xiaojiang Du iPad and Android tablets made by Samsung, ..Motorola, and Acer

127 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce dux@templ CST CIS Security In this project, the undergraduate student will TU Good CS 10 or Sophom e.edu and Privacy work with Dr. Du and his Ph.D. students on Main programming more ore, Issues of Security and Privacy Issues of Android Campus skills - Good Junior or Android Phones/Tablets. First we will identify possible communicati Senior Phones/Ta attacks on Android Phones security and on skills blets privacy. Second, we will design effective Team security schemes to defend these attacks. working skills Third, we will implement the security schemes High GPA in real Android Phones. Fourth, we will Sound math perform real experiments on Android Phones background to evaluate the effectiveness of the designed security schemes. If the experimental results are good, we will write research papers based Xiaojiang Du on the design and experiments, and submit to ACM/IEEE conferences.

CST CIS Internet of Internet of things (IoT) have approached us in TU Good CIS, 10 to 15 Things (IoT) the last few years. For example, Apple Inc. Main programming Math Security released its first smart watch in April, 2015; Campus skills High Nest Labs (acquired by Google in 2014) GPA Sound released its 3rd generation learning math thermostat in September 2015. In October background 2015, Philips released a new smart light network bridge that lets you control the Philips Hue lights using mobile apps. More and more giant IT companies added their IoT products line. IoT devices and systems have been widely deployed in various domains. There will be 20.8 billion IoT devices in total by 2020. Needless to say, it’s a huge market and a new technology innovation field.

In this project, we will study the IoT xjdu@temp vulnerabilities and develop effective security Xiaojiang Du le.edu schemes to protect billions of IoT devices and systems.

128 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Xiaoxing Xiaoxing@t CST Physics Fabrication We work mainly with superconducting thin TU Interested in physics, TBD Xi emple.edu and studies films for device applications at small and large Main research, enginee of scales. For this purpose, films of magnesium Campus hard working, ring supercond diboride (MgB2) and various layered oxides aptitude for ucting thin are grown with different deposition methods careful films for in our lab. The films are characterized in terms laboratory device of their transition temperature, critical research, application currents, surface morphology, and fond of s performance under RF conditions. The problem purpose of these studies is to investigate the solving, feasibility of these films for the use in motivated to josephson junction based devices as well as learn, basic large scale applications, such as RF cavities understandin currently being employed in particle g of physics accelerators. Xingting xingting@ CST Mathematic Quantum In this project, we are going to investigate the Main Linear Mathe 20 to 30 Seniors Wang temple.ed s p-Groups quantized version of p-groups in the classical Campus Algebra and matics u Department group theory and to explore their classification some basic in low dimensions using all sorts of modern concepts of mathematical tools. Abstract Algebra

129 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Xuebin xuebin.qin TUSM Neuroscienc Applying a Conditional and targeted cell ablation is fast TU Working hard Genetic TBD Qin @temple.e e novel cell becoming a powerful approach for studying Health - Genetics s or du knockout cellular functions and tissue regeneration in Science Cell biology molecul model for vivo. Taking advantage of the exclusive IL Y Campus ar CNS interaction with hCD59, I have developed a biology diseases novel tool to investigate the role of specific cells in the pathogenesis of human diseases. IL Y administration to the transgenic mice expressing hCD59 in specific cells can be used to generate this cell ablation model, in which IL Y specifically damages hCD59-expressing cells in the mice. We can utilize this concept to develop a new cell ablation model to study the functions of different cell types under physiologic and patho-physiologic conditions including cell differentiation and tissue development in many species. I have established multiple collaborations with Scientists in USA to further utilize this approach for their research projects in many species.

130 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Yanhua Li yanhua.li@ TUSM Pathology What is (Igs) are Monoclonal immunoglobulins TU Interested in Biology, TBD Sophom tuhs.templ and cost- identified as M-spikes on serum protein Health Medicine and Bioche ore, e.edu Laboratory effective the majority of electrophoresis (SPE) in Science Biomchemistr mistry, Junior or Medicine critiria, cut- .patients with monoclonal gammopathies Campus y, Immun Senior off can However in some patients, monoclonal Igs immunology, ology, concentrati only be detected by immunofixation data on of displays electrophoresis (IFE) since their SPE collection gamma an apparently normal pattern without and data globulin In these .M-spike abnormal bands or obvious analysis fraction for subtle abnormalities cases, SPE may show reflex such as decreased globulins. Currently, many immunofix including our institution, reflex all ,hospitals ation .g globulins for IFE specimens with decreased electropho g Our experience is that most cases with low resis have globulins but close to the normal limit efficiency of To improve the .negative IFE reflex IFE, we need to have a more cost- defined concentration effective and more We plan to .level of g globulins for reflex IFE and IFEs (~800) review all SPEs (total ~2000) cases from January 1st 2010 to December 31st globulin concentration investigate g 2011 to in the 3 groups: 1. M-spike negative SPE with globulins and negative IFE; 2. M- decreased g globulins negative SPE with decreased g spike SPE.We but positive IFE; 3. M-spike positive will determine a more accurate and cost fraction cut-off to trigger reflex effective g study will be conducted in close IFE. This of collaboration with Dr. Adil Khan, Director .Clinical Chemistry

131 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce TUSM Pathology What is risk charts and follow-up Collect data from patient TU is interesting Biology Flexible Sophom and factors for the new patients including complications, past Health in medicine or ore, Laboratory C-section? history and related laboratory data, medical Science or medical statistic Junior or Medicine .surgery as well as blood usage during the Campus science. - s Senior multiple variable Then analyze the data using data yanhua.li analysis to identify the factors which collection @tuhs.te massive bleeding and to associated with and data Yanhua Li mple.edu develop a transfusion guideline for C-section analysis patients

Yanhua Li yanhua.li@ TUSM Pathology Study of blood Current recommendation for TU Biology TBD Sophom tuhs.templ and Feedback transfusion on surgical patients is hemoglobin Health or ore, e.edu Laboratory on Blood symptomatic anemia). In less than 8 g/dl (or Science Chemist Junior or Medicine Use in Hip this study, we will educate surgeons about the Campus ry Senior Arthroplast recommended guidelines for blood transfusion y Patients medical ’and collect data from patients medical record of hip We will review .records arthroplasy patients and collect the information and other clinical transfusion information including pre-transfusion hemoglobin, other factors which possibly .associated with bleeding . This project will benefit these students study because it will introduce them to design, clinical research, data of the collection/analysis and interpretation results. Additionally, the students will benefit basics of Transfusion from learning some .Medicine and orthopedic procedures The above study will be conducted in close collaboration with Dr. Easwarian Balasubramanian, associate professor, department of orthopedic surgery

132 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Yi Rao yirao@tem CST Chemistry Two- We will synthesize novel 2D layered materials TU Physical chemist 18 Junior, ple.edu dimensiona for photovoltaic applications. We evaluate Main chemistry ry or hours senior l Layered and control the elementary processes that Campus and organic physics Organic- govern the properties and performance of chemistry Inorganic perovskite materials in photovoltaic and Hybrid for optoelectronic devices illustrated by dye Photovoltai sensitized solar cells (DSSC) and light emitting c diodes (LED). Application of these Application unprecedented measurement capabilities to s relevant materials issues benefits from inter- dependent programs in materials design, preparation, and processing.

133 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Yi Rao tuf42202 CST Chemistry Photovoltai In this undergraduate research, we aim to TU Chemist TBD Sophom @temple. c investigate both Ge nanocrystal inorganic Main ry, ore, edu application materials interactions with light and the Campus physics, Junior, s of potential for unique photovoltaic applications, enginee Senior multiple including the generation of multiple carrier ring exciton generations in Ge nanocrystals. It includes two generation parts. Part A: Characterization of linear optical from Ge properties of Ge nanocrystals using absorption, nanocrystal fluorescence, and Raman scattering s spectroscopy. The students will investigate the optical characteristics of inorganic silicon nanocrystals using a range of available spectroscopic tools. These measurements will be performed on samples consisting of Ge nanocrystals of different sizes at different solvents. The aim of part A is to understand the basic optical properties of the potential materials for multiple exciton generation, and to identify the growth conditions for production of Ge nanocrystals that exhibit the appropriate band gap and very high structural quality. Part B is to investigate surface properties of Ge nanocrystals. These experiments will be carried out using femtosecond laser systems. For inorganic Ge nanocrystals, second order properties and surface modifications of Ge nanocrystals will be examined. The purpose of the research is to expose undergraduate students to state-of-the- art ultrafast optical spectroscopy, and to hands- on train the students how to perform experiments, analyze data, and present experimental results.

134 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Yugang ygsun@te CST Chemistry This project seeks to use the home-built TU Wet chemist 10 to 15 Seniors Sun mple.edu Microfluidi microfluidic reactor for synthesizing graphene- Main Chemistry ry c synthesis supported semiconductor quantum dots, Campus of which can adsorb solar energy to drive useful graphene- chemical reactions (i.e., photocatalysis). The supported student will use the method recently quantum developed in my group to synthesize dots for graphene-supported semiconductor quantum photocatal dots including CdSe and CdS ysis Yugang ygsun@te CST Chemistry Microfluidi This project seeks to use the home-built TU Wet chemist 10 to 15 Juniors Sun mple.edu c synthesis microfluidic reactor for synthesizing graphene- Main Chemistry ry or of supported metal nanocrystals, which exhibit Campus Seniors graphene- clean surfaces for catalysis with improved supported performance. By using the method we recently metal developed, nanocatalysts can be directly nanocataly loaded to graphene support in the microfluidic sts reactor. The student will be expected to synthesize graphene-supported noble metal nanocrystals including silver, gold, platinum, palladium, and their alloys.

135 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Yury yury@tem CST Mathematic Computati Project description: TU Interest in Mathe 10 to 15 Juniors Grabovsky ple.edu s on of Effective properties of composite materials Main theoretical matics or rotationally strongly depend not only on the Campus research. Seniors invariant composition, but also on the microstructure. Strong Jordan However, in some special mathematical multialgebr situations it is possible to derive formulas background. as with relating effective properties of Strong Maple the composite and properties of the programming constituent materials, no matter what the skills. Grade microstructure is. There is a general theory for A in identifying all such special Theoretical situations, called "exact relations". Each exact Linear relation can be described in Algebra terms of a nice algebraic object: a subspace of MATH 3051. matrices, which is closed with programming respect to several special multiplications skills. Grade (different from usual matrix A in multiplications), each of which makes this Theoretical subspace a Jordan algebra. For this Linear reason, these objects will be called Jordan Algebra multialgebras. To simplify the MATH 3051. task of finding all Jordan multialgebras we restrict the attention only to the rotationally invariant ones. The goal of the project is to write a Maple program that computes all rotationally invariant Jordan multialgebras corresponding to thermoelectroelastic composites, which couple thermoelastic and piezoelectric effects

136 11/1/16 Faculty Email College Faculty Project Project Description Project Important Student Hours Class Name Address Department title Locatio selection Majors Per Preferen n criteria Desired Week ce Zoran zoran.obra CST CIS - Data Predictive Predicting the system behaviors by analyzing TU Interdisciplin Comput TBD Obradovic dovic@tem Analytics analytics in big data. Applications include social networks, Main ary interests; er ple.edu Center, big data medicine, climate and environment. For more Campus Self- Science, Computer details see motivation; Statistic and http://www.dabi.temple.edu/~zoran/ Problem s, Information solving skills; Physics, Science, Some Biology, Statistics programming Chemist experience in ry, any language Pharma -the projects cy, will be Geology tailored to , the students' Environ level of mental preparation. Science

137 11/1/16