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Jour-Marine-Medical-Society-1999-Vol-1-No-2.Pdf A l\l|A ffieL MARINEMEDICAL SOCIETY (RegdF-3611) President Surg VADM JC SHARMA VSM, PHS DGMS(NAVY) VicePresidents Surg RADM VK PAHWA SurgRADM HP MUKHERJEE VSM CMO WesternNaval Command CommandinsOfficer.INHS Asvini ExecutiveCommittee Surg Cmde PS VALDIYA Surg Cmde SP MALHOTRA DirectorINM DMS (P&M) NavalHeadquarters Surg CmdeWP THERGAONKAR SurgCmde BPS Rawat, VSM CMO, EasternNaval Command CMO,SouthemNaval Command Surg Cmde ML GUPTA VSM Surg Cmde AK CHAUDHARJ DentalAdv. (Navy) DMS (H& S) Naval Headquarters Surg Capt S NANGPAL Surg Cdr D D'COSTA Sr.Adv MarineMedicine INS Vajrabahu Surg LCdr S BHANDARI Surg LCdr GD BHANOT SHO(Mumbai) INS Abhimanyu Secretary Surg Cdr KBS CHEEMA Treasurer Surg Capt GS GREWAL Addressfor Correspondence Secretary MARINE MEDICAL SOCIETY Instituteof NavalMedicine, Colaba,Mumbai 400 005.INDIA Fax:022-2150670 E-mail: [email protected] JOURNAL OF MARINE MEDICAL SOCIETY JULY-DEC1999 PublishedBiannually Chief Editor SUTgRADMVKPAIIWA Editor Surg Capt S NANGPAL Co Editors Surg Capt RATAN SINGH SuTgCdTGIRISHGUPTA Sub Editors Naval Headquarters SurgCdTAAHIJJANM Western Naval Command Surg Cdr D D'COSTA Eastern Naval Command Surg Cdr VRG PATNAIK Southern Naval Command SuTgCdTMJJOHN Editorial AdvisoryBoard SurgCmde (D) MLGUPTA,VSM Surg CmdeRTAWASTHI CoIHSPRUTHI SurgCaptRAMESHKLIMAR SurgCapt KK DUTTA GUPTA SurgCdrB SUDARSAN Addressfor Correspondence Editor JOURNAL OF MARINE MBDICAL SOCIETY Instituteof NavalMedicine, Colaba.Mumbai 400 005. Telefax:022-215 0670 E-mail: [email protected] Printed and Publishedby Surg Cdr KBS Cheemaon behalf of Director Generalof Medical Services(Navy) and printed at Typo Graphics,Mumbai 400 103 and publishedat Instituteof Naval Medicine, Colaba,Mumbai 400 005. Editor: Surg Capt S Nangpal - t orix REi JOURNAL OF MARINB MEDICAL SOCIETY MU CONTENTS Surg From The Editor's Desk 6l Surg NEW FRONTIERS ABSl Advancesin MolecularBiology' BeamonAgarwal Apn malar The PolymeraseChain Reaction and8 SurgI't cdr H Mani, surg Lt cdr cN chaudhari, surg cdr RN Misra, surg capt MK Gupta above beenr Infectioushoteinaceous Particles - Prions 69 Lt Col SPMittal, SurgIs Cdr Mohit Goel KEY ORIGINAL ARTICLE INTI Resurgenceof Malariaat Mumbai 'tl CantonmentDuring 1998-99 Or SurgCapt KK Dutta Gupta,Surg MDM VK Pahwa, SurgLt Cdr S Bhandari, in l9i Surgls Cdr M llankum/zren hogr Blood PressureProfile Under Hyperbaric Conditions globa SurgCdr MJ John, SurgCapt S Nangpal count HyperbaricOxygen for IndustrialMedical SerUp 83 ticida SurgLt P Gokulakrishnan under (NMr QualityAssurance of Regenerativechemical Being used in submarineEscape Set dence SurgGdr B Sudarsan,Surg Cdr MJ John, SurgCapt S Nangpal yearI SexualDimorphism in CoronaryArtery Disease: AnatomicalFactors result UshaDhall, BasantLal duetr Managementand Visual Outcomeof Patientswith OpenGlobe Injuries 95 Th S Natarajan, ShyamaSatyan differ Roleof SerumThyroglobulin in The Managementof Well DifferentiatedThyroid Cancer 98 specil SurgCdr B Fanthome,Sandeep Sebastian troopl Challengesin BurnShock Resuscitation 103 befro SurgCdr YPMonga risk r becon An Analysisof HundredSuccessful Pregnancies in Infertilecouples 106 SurgCdr SushilKumar, SurgCmde RT Awasthi, Surg L CdrA Kapoor, froml Surg L Cdr S Sinivas, P Verma additi onlee Alcohol in The MedicolegalRegister u0 SurgCdr Alh^adAnant Pawar A notic( GrowthPattem in The Frist Six Monthsof Life A Semi-longitudinalStudy tt4 to the SurgLt Cdr S Narayan,Surg Cmde WP Thergaonkar, Surg CdrT Nagaraja locall SerumPotassium kvels in Beta-2Agonist Nebulisation of Asthmaticchildren 120 surg L cdr s Das, surg capt KS Bawa, P Agarwal, surg cdr s Mathai, surg cdr G Gupta *Sr.Ar Mumbr Jour.t .t.q.sn RBPoRT Congenital Malaria - A Report on Two Cases 128 Surgls Cdr S Narayan, SurgLt CdrV Hande, SurgLt Cdr N Nath Congenital Cyst of The Spleen - A CaseReport 130 lt Col G Ravindranath, VSM, Surg Capt Ramesh Kumar, Surg Cdr G Gupta, Dr. TanveerA Majeed A Case of Natal Teeth 132 Surg Lt (D) SS Chopra, Surg Lt CdrV Hande, Surg lt Cdr S Narayan . BOOK REVIEW 134 JOURNALWATCH 135 , GUIDELINESTO AUTHORS t37 From water bottles to wind-up to)4s Frommugs to milk pouches From jars to juicers Reliancetouches eve$odyrslife. From pipes to packaging From gas-masksto garbagecans From bottles to bathtubs ,As 6e f.got p"fytto manufac'tnerin dre country, Relianceprovides the raw materialsfo making alrrost eveaykind of plastic youlve seen.This has enabld Relianceto touch the lives of millions for the better.Not just brough the plastic prodrrts that it helps qeate but also becausealt ReliancepLstics ale recyclableand eco-friendly, a A Reliance Inftrolrleb Llmlted o I --M;i;;-Actt|tbfre F zP -A -'I. 6-:; /o-- r\ /**\ \:--:7 -:!zz HiBb Ddsity tirrdldD.Bity bl)ryinyl Chlorid. Folypopylcm Fobrthylcnc Folycthy'cm blpthy{cnc (F/C) (PP) T@phthaL!. (}IDPE) OIDPE) (PET) - FROM THE EDITOR'SDESK The releaseof this issuecoincides with the NationalConference on Marine Medicinebeing held pt Mumbai. This is alsothe last issue of theJournal in thismillennium. Just as this last issue of themillennium contains threearticles from eminentcivilian doctors,we aresure that the Journal will continueto receivearticles from our civilian counterpartson a regularbasis. Dr. S.Natrajan an eminent and renowned vitreo retinal surgeon shares his experiencein themanagement ofopenglobe injuries ofthe eye.Hyperbaric facilities at variousindustrial set ups may help in treatingseveral occupationaldisease and this is the recommendationgiven by SurgLt. Gokulkishnanin his articletitled "HyperbaricOxygen for Industrialsetup". Advancesin molecularbiology, the inventionof the polymerasechain reaction and discovery of Prions havebeen some of the advancesin the field of basicmedical sciences. Their contributiontowards finding the causeof diseaseand suggesting remedies for the sameh3ve been major achievements. Three articles in the currentissue highlight these advances. "Sexualdimorphism in coronaryartery disease - anatomicalfactors" an articleby Dr. Dhall et al. makes interestingreading. That there are structural (both gross and microscopic) differences between the coronaries of malesand females has been emphasised by theauthors. They conclude that narrowercoronaries in relation to heartsize and thicker tunica intima in malesmay be someof the anatomicalfactors making them more susceptibleto coronaryartery disease. Hitherto,the staiusof borderlinehypertensives especially in divers,submarines and patients undergoing hyperbaricoxygen therapy was not clear,as literature was scanty even on theinternet, but thearticle "Blood pressureprofile underhyperbaric condition" by SurgCdr MJ Johnet al in thecurrent journal deals with this issuecomprehensively. Havingsaid all this,it is our solemnduty to onceagain remind ourselves of the supremesacrifice by the valiantmembers of the ArmedForces who laid downtheir lives in the defenceof our country'sborders in the recentconflict. l.et us observea minute'ssilence and rededicate our selvesto the causeat handin the comingmillennium. JaiHind! NANGPAL) Jour. Marine Medical Society,July-Dec 1999,Vol. I, No.2 6I Qrtlunefl ast V ompliments ftom IryS.IESICA CHEMICALS ByramjiMansion, lst Floor, SirPM Road,Fort, 'Mumbai40000l. Phones:266 4052,2660574,2666283 New Frontiers ADVANCESIN MOLECULARBIOLOGY BEAMON AGARWAL INTRODUCTION Cell adhesion 1.s molecularbiology relevantto us? Molecular Cell adhesion acts as a contact inhibitor of cell questionshow a normal human proliferation. are I biology ma- The main adhesionmolecules the I-chine worksbiologically and at whatprecise site lectins, selectinsand the cadherins.Deregulated cell a disorderin this machineresults in disease. adhesionleads to proliferation of cells which is not physiological. Mediators of cell adhesionhelp us in The basic advances recently occurring are in the genesisof tumour development. embryogenesis,cell cycle, cell adhesion,cell com- explaining munication, signal transduction and cell death or Cell defence ' apoptosis.To beginwith, how doesa humanevolve? We all have been programmed with a software - The moment an organismis born it entersinto the DNA on which we develop our phenotype. The Darwinian survival for existence.Even the smallest evolved human body hasbeen granted a neuroendo- organism is met by numerouspathogens which can crine control which regulatesour progam. destroy it. The one that is able to survive is depend- ent on cell immunity. Malfunction of this leadsto Cell cycle autoimmunityor immunodeficiency.The majorhis- After conceptioncell proliferation leadsto differ- tocompatibility complex or the HLA system has provided ent stagesof embryogenesis..Each system is devel- been on nearly all cells which acts as oped from individual collection of cells. The cell identificationmarker unique to an individual. Any cycle hasmainly four stagesGl, G2, S andM. In the pathogenattacking the body but having a different cell cycle the principal regulators are the cyclins - antigenstatus is recognisedby the immune cells B cdkl, cdk2, cdk4 and p21. Improper activationof and T. The T cells with the help of macrophages pathogen. theseresults in unregulatedcell growth-hyperplasia/ ultimately led to cytotoxic death of the neoplasm.Understanding about the loss or disorder This is regulated by IL-l and IL-Z. HLA system of a cyclin in individual tumour helps us in under- forms the basis of transplant.That a mother is able standing the biology of tumours. to hold another organism for approximately 290 dayswithout rejection can also be explained.Hyper- Cell communication active rejectionleads to hypenensitivity
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