Molecular Psychiatry (2020) 25:2645 https://doi.org/10.1038/s41380-020-00900-6

IMAGE

Autism-like behavior in Pianp-deficient mice is associated with decreased neuronal Erdr1 expression and altered GABAB receptor signaling

1 1 2 3 3 Manuel Winkler ● Siladitta Biswas ● Stefan M. Berger ● Moritz Küchler ● Laurens Preisendörfer ● 4 4 4 2 5 6 Myeongjeong Choo ● Simon Früh ● Pascal D. Rem ● Thomas Enkel ● Bernd Arnold ● Dorde Komljenovic ● 7 1,8 4 3 2 Carsten Sticht ● Sergij Goerdt ● Bernhard Bettler ● Oliver von Bohlen und Halbach ● Dusan Bartsch ● Cyrill Géraud1,8,9

© Springer Nature Limited 2020 1234567890();,: 1234567890();,:

Fig. 1 In situ hybridization of Erdr1 (red) of control and PianpKO accompanied by impaired presynaptic GBR inhibition of glutamate brains. Left panel: whole brain coronal sections. Right panel: higher release and resulted in characteristic features of an autism-like beha- magnifications of the neocortex. PianpKO mice showed decreased vioral phenotype. For more information, please refer to the paper by Erdr1 expression in neurons. Functionally, loss of Pianp was also Winkler et al. on pages 2979-2993.

* Cyrill Géraud Basel, Basel, Switzerland [email protected] 5 Division of Molecular Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany 1 Department of Dermatology, Venereology, and Allergology, University Medical Center and Medical Faculty Mannheim, 6 Division of Medical Physics in Radiology, German Cancer Heidelberg University, and Center of Excellence in Dermatology, Research Center (DKFZ), Heidelberg, Germany Mannheim, Germany 7 Center for Medical Research, Medical Faculty Mannheim, 2 Department of Molecular Biology, Central Institute of Mental Heidelberg University, Mannheim, Germany Health and Medical Faculty Mannheim, Heidelberg University, 8 European Center for Angioscience, Medical Faculty Mannheim, Mannheim, Germany Heidelberg University, Mannheim, Germany 3 Institute of Anatomy and Cell Biology, University Medicine 9 Section of Clinical and Molecular Dermatology, Medical Faculty Greifswald, Greifswald, Germany Mannheim, Heidelberg University, Mannheim, Germany 4 Department of Biomedicine, Institute of Physiology, University of