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r o ) ISMP © 2013 Humalog Treat signs of hypoglycemia immediately! Low Blood Sugar Too much insulin causes hypoglycemia

Signs of hypoglycemia Hypoglycemia is caused by too much insulin or increased work or exercise without (low blood sugar) eating. Symptoms of hypoglycemia may be different for each person and can change dizziness from time to time. Hypoglycemia can affect your ability to think and react quickly, so hunger sweating driving a car could be risky. Severe hypoglycemia can lead to loss of consciousness, feeling shaky headache seizures, brain damage, or even death. Know the symptoms of hypoglycemia and treat fast heartbeat confusion it quickly by drinking juice or a sugar-containing beverage, or eating sugar or candy. lightheadedness irritability Talk to your doctor if hypoglycemia is a problem for you. Topics Fast Facts Generic name insulin lispro (pronounced IN soo lin LYE spro) (no generic available) Common brand names Humalog, Humalog KwikPen, HumaPen, other Humalog pens Type of insulin, onset, duration Rapid-acting insulin; begins working in 15 to 30 minutes and lasts for 5 hours or less Uses Treatment of type 1 and type 2 diabetes mellitus to improve control of blood glucose When to take the insulin Humalog should be injected under the skin within 15 minutes before or immediately after a meal Usual dose The frequency and dose of insulin are unique to each individual Daily doses of insulin are based upon body weight, diet, activity level, age, individ - ual sensitivity to insulin, type of diabetes (1 or 2) Multiple daily doses according to blood glucose levels are typical Injecting the insulin See safety tip #2 (other side of page) to determine if Humalog can be mixed with another insulin before injection Ask your doctor, nurse, or pharmacist to show you how to draw your dose of insulin into a syringe and inject it, select the dose on a pen device and inject the insulin, or use an insulin pump Before injecting a dose, take the chill off refrigerated insulin by gently rolling the vial, pen, or cartridge between the palm of both hands (do not shake the insulin vigorously) Using a syringe or insulin pen, i nject the insulin below the skin (not in the muscle) in the upper thighs, upper arms, buttocks, or abdomen; the site of the injection should be changed (rotated) with each dose Don’t use Humalog if the insulin appears cloudy instead of clear and colorless Special instructions and precautions Meals should be eaten no longer than 15 minutes before or immediately after injection Follow the diet prescribed by your doctor Keep your eating habits and exercise regular Tell the doctor who prescribes insulin about any new medicines you are taking Do not share insulin pens, cartridges, or syringes/needles with others Safety during pregnancy/breastfeeding Talk to your doctor about managing your diabetes during pregnancy and breastfeeding

Storage and disposal Store unopened vials, cartridges, and pens in the refrigerator until first use (do not freeze) After first use, store vials in the refrigerator or at room temperature; discard after 28 days After first use, store cartridges and insulin pens at room temperature (do not refriger - ate); discard after 28 days Safely dispose of used syringes/needles, pens, and lancets (safety tip #3, other side) Most common side effects Hypoglycemia (low blood sugar); see signs and treatment of hypoglycemia above Low potassium blood levels, fast heart rate, fatigue, headache, hunger Other conditions to report to your doctor Chest pain or palpitations, persistent fatigue, confusion, numbness of mouth, lips, or tongue, muscle weakness or tremors, vision changes, flu-like symptoms Swelling, itching, redness, warmth, or pain at the injection site Herbals that should not be taken with Humalog These herbals can lower your blood glucose: chromium, garlic, gymnema Prescription medicines that should not be taken Many prescription medicines can affect your blood sugar levels and insulin needs with Humalog Tell your doctor about all the medicines you take, particularly new medicines Special tests your doctor may prescribe Patients are often asked to test their own blood glucose using home testing equip - ment, test their urine for sugar and acetone, and take their blood pressure regularly To monitor your diabetes, y our doctor may periodically test your blood levels for hemoglobin A1c, potassium, cholesterol, and substances that measure kidney function

This information does not replace the need to follow your doctor’s instructions and read the drug information leaflet provided with your prescription .

This project was supported by grant number R18HS017910 from the Agency for Healthcare Research and Quality. The content is solely the responsibility of the authors and does not represent the official views of the Agency for Healthcare Research and Quality.