(12) United States Patent (10) Patent No.: US 8,765,685 B2 B00kbinder Et Al
US008765685B2 (12) United States Patent (10) Patent No.: US 8,765,685 B2 B00kbinder et al. (45) Date of Patent: *Jul. 1, 2014 (54) METHODS FORTREATING EDEMABY (52) U.S. Cl. ADMINISTERING ASOLUBLE USPC .......................... 514/20.9; 514/21.2:435/201 HYALURONIDASE GLYCOPROTEIN (58) Field of Classification Search (SHASEGP) USPC ................................. 514/20.9, 21.2:435/201 See application file for complete search history. (75) Inventors: Louis Bookbinder, San Diego, CA (US); Anirban Kundu, San Diego, CA (56) References Cited (US); Gregory I. Frost, Del Mar, CA (US) U.S. PATENT DOCUMENTS 3,536,809 A 10/1970 AppleZweig .................... 424/28 (73) Assignee: Halozyme, Inc., San Diego, CA (US) 3,598,123 A 8, 1971 Zaffaroni ...................... 424/435 (*) Notice: Subject to any disclaimer, the term of this (Continued) patent is extended or adjusted under 35 U.S.C. 154(b) by 0 days. FOREIGN PATENT DOCUMENTS This patent is Subject to a terminal dis CA 1243,948 11, 1988 claimer. CA 23.18356 T 2000 (Continued) (21) Appl. No.: 13/506.783 OTHER PUBLICATIONS (22) Filed: May 16, 2012 Letter/Written Disclosure of the Information Disclosure Statement for the above-referenced application, mailed on Jul. 12, 2012, 3 (65) Prior Publication Data pageS. US 2012/O251620 A1 Oct. 4, 2012 (Continued) Primary Examiner — Rosanne Kosson Related U.S. Application Data (74) Attorney, Agent, or Firm — McKenna Long & Aldridge (60) Continuation of application No. 12/378.969, filed on LLP, Stephanie Seidman Feb. 20, 2009, now Pat. No. 8,202,517, which is a division of application No. 10/795,095, filed on Mar.
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