CD41 (ITGA2B) Mouse Monoclonal Antibody [Clone ID: CA3] Product Data
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OriGene Technologies, Inc. 9620 Medical Center Drive, Ste 200 Rockville, MD 20850, US Phone: +1-888-267-4436 [email protected] EU: [email protected] CN: [email protected] Product datasheet for AM32081PU-N CD41 (ITGA2B) Mouse Monoclonal Antibody [Clone ID: CA3] Product data: Product Type: Primary Antibodies Clone Name: CA3 Applications: ELISA, IHC, WB Recommended Dilution: Western blotting: 1/1000. Immunohistochemical on Frozen Sections. Other Immunoassays for cellular and tumor biology. Reactivity: Human Host: Mouse Isotype: IgG1 Clonality: Monoclonal Immunogen: Partially purified platelet glycoprotein IIb/IIIa complex. Hybridoma produced by fusion between myeloma cells and Balb/c spleen cells. Specificity: The antibody clone CA3 reacts with the alpha-IIb-subunit of the beta-integrins. Reacts specifically with platelets, megakaryocytes and leukemic cells able to megakaryocytic differentiation. Formulation: PBS State: Ig Fraction State: Liquid Ig fraction Stabilizer: 1.0% BSA Preservative: 0.09% Sodium Azide Concentration: lot specific Conjugation: Unconjugated Storage: Store the antibody undiluted at 2-8°C. Stability: Shelf life: one year from despatch. Gene Name: integrin subunit alpha 2b Database Link: Entrez Gene 3674 Human P08514 This product is to be used for laboratory only. Not for diagnostic or therapeutic use. View online » ©2021 OriGene Technologies, Inc., 9620 Medical Center Drive, Ste 200, Rockville, MD 20850, US 1 / 2 CD41 (ITGA2B) Mouse Monoclonal Antibody [Clone ID: CA3] – AM32081PU-N Background: Integrin alpha 2b (CD41) is a calcium-dependent, noncovalently associated heterodimer and contains a heavy chain (GPIIb alpha) and a light chain (GPIIb beta) linked by a single disulfide bond. The Integrin alpha 2B chain interacts with the Integrin beta 3 subunit/CD61 to form the platelet glycoprotein complex, gpIIb/IIIa. It is expressed on platelets and megakaryocytes. Ligands for the gpIIb/IIIa heterodimer include fibrinogen, von Willebrand factor, fibronectin, vitronectin, and thrombospondin. The gpIIb/IIIa complex is the major Integrin on platelets and is important for platelet adhesion and aggregation. The alpha IIb-Integrin subunit is a specific marker for platelets and megakaryocytes and can be utilized for this purpose in various immunological techniques. Synonyms: Integrin alpha-IIb, GP2B, ITGAB, GPalpha IIb This product is to be used for laboratory only. Not for diagnostic or therapeutic use. ©2021 OriGene Technologies, Inc., 9620 Medical Center Drive, Ste 200, Rockville, MD 20850, US 2 / 2.