Autophagy and Phagocytosis Converge for Better Vision Thomas A

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2014 Autophagy and phagocytosis converge for better vision Thomas A. Ferguson Washington University School of Medicine in St. Louis

Douglas R. Green St. Jude Children's Research Hospital

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Recommended Citation Ferguson, Thomas A. and Green, Douglas R., ,"Autophagy and phagocytosis converge for better vision." Autophagy.10,1. 165-167. (2014). https://digitalcommons.wustl.edu/open_access_pubs/2640

This Open Access Publication is brought to you for free and open access by Digital Commons@Becker. It has been accepted for inclusion in Open Access Publications by an authorized administrator of Digital Commons@Becker. For more information, please contact [email protected]. St. Jude Children’s Research Hospital; Memphis, TN USA TN Memphis, Hospital; Research Children’s Jude St. www.landesbioscience.com http://dx.doi.org/10.4161/auto.26735 10/07/2013Accepted: 10/04/2013 Revised: 08/20/2013 Submitted: [email protected] Email: *Correspondence to: Thomas A Ferguson; photoreceptors epithelium, pigment all- A, 11- cycle, visual vision, Keywords: 1 A Ferguson Thomas converge for vision better phagocytosis and Autophagy A Department of Ophthalmology and Visual Sciences; Washington University in St. Louis; School of Medicine; St. Louis, MO USA; MO USA; Louis, St. ofMedicine; School Louis; St. in University Washington Sciences; Visual and ofOphthalmology Department http://dx.doi.org/10.1016/j.cell.2013.06.012 cycle. visual the Z Kolesnikov to: Punctum utophagy 10:1, 165–167; January 2014;©2014LandesBioscience utophagy 10:1,165–167;January , Green

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©2014 Landes Bioscience. Do not distribute. www.landesbioscience.com autophagic defects might contributeto might defects autophagic that hypothesized autophagy. It often is to attributed often vision in dent defects for age-depen some of the account might LAP defective that exists possibility the Second, LAP. during present also are features these as cells, RPE phagocytic in autophagy conventional to measure puncta GFP-LC3 or blots forquantify LC3 ern west to perform It no sufficient longer is RPE. the in phagocytosis and autophagy between distinction the blurred have ies stud our standpoint, From apractical autophagy. and of phagocytosis, vision, study for the of implications a number have results These cycle. visual classical the supports but also renewal, disk ceptor photore supports LAP via degradation and tips POS of the Phagocytosis vision. ( phagocytosis RPE and cycle visual of the Fig. Our results demonstrate a convergence aconvergence demonstrate results Our

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- - - - exciting process will open new avenuesfor new open will process exciting this Exploring function. cell photoreceptor and on RPE machinery autophagy of the impact the about to think which in way new afundamentally represents vision port to sup autophagy) and (phagocytosis ways path degradative lysosomal intracellular observations. for these account might aging with LAP Defective condition. this improve Acan vitamin nutritional with supplementation and vision night with difficulties have why elderly individuals areason be may Arecovery vitamin in areduction Finally, designed. be can tions interven therapeutic meaningful before autophagy from LAP to distinguish ways we determine that tor. it crucial is Thus, fac acontributing as examined be also should LAP in defects that suggest would we and (AMD), degeneration macular age-related as such diseases eye age-related The interplay between 2 important 2 important between interplay The Autophagy

- - - - phagy machinery and disease. and machinery phagy auto the between relationships the ing, manipulat ultimately and understanding, authors for their hard work. hard for their authors co- excellent our to all Thanks MD). (Clarksburg, Foundation BrightFocus the and IN) (Columbus, Foundation Reeves Almen Mildred and Reeves Marshall Carl the York, (New NY), to Prevent Blindness Research from received also was Support (EY02687). grant core Sciences Visual and of Ophthalmology Department a and (DRG), AI40646 and (DRG), EY015570(TAF), AI44848 (TAF), EY06765 Grants of Health Institutes disclosed. Disclosure of Potential Conflicts of Interest Conflicts ofPotential Disclosure This work was supported by National by National supported work was This were of interest conflicts No potential Acknowledgments 167 - -