EPCRA Section 312 Extremely Hazardous Substance (Ehss) List and Threshold Planning Quantities
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Propoxur United States Environmental Protection Agency
United States Prevention, Pesticides EPA738-R-97-009 Environmental Protection And Toxic Substances August 1997 Agency (7508W) Reregistration Eligibility Decision (RED) PROPOXUR UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460 OFFICE OF PREVENTION, PESTICIDES AND TOXIC SUBSTANCES CERTIFIED MAIL Dear Registrant: I am pleased to announce that the Environmental Protection Agency has completed its reregistration eligibility review and decisions on the pesticide chemical case propoxur. The enclosed Reregistration Eligibility Decision (RED) contains the Agency's evaluation of the data base of this chemical, its conclusions of the potential human health and environmental risks of the current product uses, and its decisions and conditions under which these uses and products will be eligible for reregistration. The RED includes the data and labeling requirements for products for reregistration. It may also include requirements for additional data (generic) on the active ingredient to confirm the risk assessments. To assist you with a proper response, read the enclosed document entitled "Summary of Instructions for Responding to the RED." This summary also refers to other enclosed documents which include further instructions. You must follow all instructions and submit complete and timely responses. The first set of required responses is due 90 days from the receipt of this letter. The second set of required responses is due 8 months from the date of receipt of this letter. Complete and timely responses will avoid the Agency taking the enforcement action of suspension against your products. If you have questions on the product specific data requirements or wish to meet with the Agency, please contact the Special Review and Reregistration Division representative Bonnie Adler (703) 308-8523. -
Adverse Effects of Organophosphorus Pesticides on the Liver: a Brief Summary of Four Decades of Research
Karami-Mohajeri S, et al. Adverse effects of OPs on the liver: a brief research summary Arh Hig Rada Toksikol 2017;68:261-275 261 Review DOI: 10.1515/aiht-2017-68-2989 Adverse effects of organophosphorus pesticides on the liver: a brief summary of four decades of research Somayyeh Karami-Mohajeri1,2, Ahmad Ahmadipour2, Hamid-Reza Rahimi1,2, and Mohammad Abdollahi3,4 Pharmaceutics Research Center, Institute of Neuropharmacology1, Department of Toxicology and Pharmacology, Faculty of Pharmacy2, Kerman University of Medical Sciences, Kerman, Pharmaceutical Sciences Research Center3, Department of Toxicology and Pharmacology4, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran [Received in May 2017; Similarity Check in May 2017; Accepted in December 2017] Organophosphorus pesticides (OPs) are widely used volatile pesticides that have harmful effects on the liver in acute and chronic exposures. This review article summarises and discusses a wide collection of studies published over the last 40 years reporting on the effects of OPs on the liver, in an attempt to propose general mechanisms of OP hepatotoxicity and possible treatment. Several key biological processes have been reported as involved in OP-induced hepatotoxicity such as disturbances in the antioxidant defence system, oxidative stress, apoptosis, and mitochondrial and microsomal metabolism. Most studies show that antioxidants can attenuate oxidative stress and the consequent changes in liver function. However, few studies have examined the relationship between OP structures and the severity and mechanism of their action. We hope that future in vitro, in vivo, and clinical trials will answer the remaining questions about the mechanisms of OP hepatotoxicity and its management. -
12.18 Carbofuran Carbofuran (CAS No
12. CHEMICAL FACT SHEETS WHO (2003) Cadmium in drinking-water. Background document for preparation of WHO Guidelines for drinking-water quality. Geneva, World Health Organization (WHO/SDE/WSH/03.04/80). 12.18 Carbofuran Carbofuran (CAS No. 1563-66-2) is used worldwide as a pesticide for many crops. Residues in treated crops are generally very low or not detectable. The physical and chemical properties of carbofuran and the few data on occurrence indicate that drink- ing-water from both groundwater and surface water sources is potentially the major route of exposure. Guideline value 0.007 mg/litre Occurrence Has been detected in surface water, groundwater and drinking-water, generally at levels of a few micrograms per litre or lower; highest concentration (30 mg/litre) measured in groundwater ADI 0.002 mg/kg of body weight based on a NOAEL of 0.22 mg/kg of body weight per day for acute (reversible) effects in dogs in a short-term (4- week) study conducted as an adjunct to a 13-week study in which inhibition of erythrocyte acetylcholinesterase activity was observed, and using an uncertainty factor of 100 Limit of detection 0.1 mg/litre by GC with a nitrogen–phosphorus detector; 0.9 mg/litre by reverse-phase HPLC with a fluorescence detector Treatment achievability 1 mg/litre should be achievable using GAC Guideline derivation • allocation to water 10% of ADI • weight 60-kg adult • consumption 2 litres/day Additional comments Use of a 4-week study was considered appropriate because the NOAEL is based on a reversible acute effect; the NOAEL will also be protective for chronic effects. -
Carbamate Pesticides Aldicarb Aldicarb Sulfoxide Aldicarb Sulfone
Connecticut General Statutes Sec 19a-29a requires the Commissioner of Public Health to annually publish a list setting forth all analytes and matrices for which certification for testing is required. Connecticut ELCP Drinking Water Analytes Revised 05/31/2018 Microbiology Total Coliforms Fecal Coliforms/ E. Coli Carbamate Pesticides Legionella Aldicarb Cryptosporidium Aldicarb Sulfoxide Giardia Aldicarb Sulfone Carbaryl Physicals Carbofuran Turbidity 3-Hydroxycarbofuran pH Methomyl Conductivity Oxamyl (Vydate) Minerals Chlorinated Herbicides Alkalinity, as CaCO3 2,4-D Bromide Dalapon Chloride Dicamba Chlorine, free residual Dinoseb Chlorine, total residual Endothall Fluoride Picloram Hardness, Calcium as Pentachlorophenol CaCO3 Hardness, Total as CaCO3 Silica Chlorinated Pesticides/PCB's Sulfate Aldrin Chlordane (Technical) Nutrients Dieldrin Endrin Ammonia Heptachlor Nitrate Heptachlor Epoxide Nitrite Lindane (gamma-BHC) o-Phosphate Metolachlor Total Phosphorus Methoxychlor PCB's (individual aroclors) Note 1 PCB's (as decachlorobiphenyl) Note 1 Demands Toxaphene TOC Nitrogen-Phosphorus Compounds Alachlor Metals Atrazine Aluminum Butachlor Antimony Diquat Arsenic Glyphosate Barium Metribuzin Beryllium Paraquat Boron Propachlor Cadmium Simazine Calcium Chromium Copper SVOC's Iron Benzo(a)pyrene Lead bis-(2-ethylhexyl)phthalate Magnesium bis-(ethylhexyl)adipate Manganese Hexachlorobenzene Mercury Hexachlorocyclopentadiene Molybdenum Nickel Potassium Miscellaneous Organics Selenium Dibromochloropropane (DBCP) Silver Ethylene Dibromide (EDB) -
COMBINED LIST of Particularly Hazardous Substances
COMBINED LIST of Particularly Hazardous Substances revised 2/4/2021 IARC list 1 are Carcinogenic to humans list compiled by Hector Acuna, UCSB IARC list Group 2A Probably carcinogenic to humans IARC list Group 2B Possibly carcinogenic to humans If any of the chemicals listed below are used in your research then complete a Standard Operating Procedure (SOP) for the product as described in the Chemical Hygiene Plan. Prop 65 known to cause cancer or reproductive toxicity Material(s) not on the list does not preclude one from completing an SOP. Other extremely toxic chemicals KNOWN Carcinogens from National Toxicology Program (NTP) or other high hazards will require the development of an SOP. Red= added in 2020 or status change Reasonably Anticipated NTP EPA Haz list COMBINED LIST of Particularly Hazardous Substances CAS Source from where the material is listed. 6,9-Methano-2,4,3-benzodioxathiepin, 6,7,8,9,10,10- hexachloro-1,5,5a,6,9,9a-hexahydro-, 3-oxide Acutely Toxic Methanimidamide, N,N-dimethyl-N'-[2-methyl-4-[[(methylamino)carbonyl]oxy]phenyl]- Acutely Toxic 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (Methyl-CCNU) Prop 65 KNOWN Carcinogens NTP 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) IARC list Group 2A Reasonably Anticipated NTP 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (Lomustine) Prop 65 1-(o-Chlorophenyl)thiourea Acutely Toxic 1,1,1,2-Tetrachloroethane IARC list Group 2B 1,1,2,2-Tetrachloroethane Prop 65 IARC list Group 2B 1,1-Dichloro-2,2-bis(p -chloropheny)ethylene (DDE) Prop 65 1,1-Dichloroethane -
Effect of Chlorpyrifos Oxon on M2 Muscarinic Acetylcholine Receptor Trafficking”
EFFECT OF CHLORPYRIFOS OXON ON M2 MUSCARINIC ACETYLCHOLINE RECEPTOR REGULATION BY ELMAR MABUNGA UDARBE Doctor of Veterinary Medicine University of the Philippines Los Baños College, Laguna, Philippines 1999 Submitted to the Faculty of the Graduate College of Oklahoma State University in partial fulfillment of the requirements for the Degree of MASTER OF SCIENCE July, 2004 EFFECT OF CHLORPYRIFOS OXON ON M2 MUSCARINIC ACETYLCHOLINE RECEPTOR REGULATION Thesis Approved: DR. CAREY N. POPE Thesis Advisor DR. CYRIL C. CLARKE DR. CHARLOTTE C. OWNBY DR. DORIS K. PATNEAU DR. AL CARLOZI Dean of Graduate College ii ACKNOWLEDGMENTS My sincerest gratitude goes to my major advisor, Dr. Carey N. Pope for the intelligent supervision, for providing inspiration to do this work. I am also thankful to my committee members, Dr. Cyril Clarke, Dr. Charlotte Ownby and Dr. Doris Patneau for helpful comments on the content and form of this manuscript. I am indebted to the Fulbright-Philippine Agriculture Scholarship Program (FPASP) and the Philippine American Education Foundation (PAEF) whose exchange program deepened my understanding of the U.S. culture and its people and allowed me to promote mutual understanding between the U.S. and the Philippines. I am grateful to the University of the Philippines in Mindanao (UPMINDANAO) for supporting my pursuit for graduate studies, the National Institute of Environmental Health Sciences (NIEHS), Oklahoma State University Board of Regents and Dr. Sidney Ewing, Wendell H. and Nellie G. Krull Endowed professor for the financial assistance. I am also thankful to the following: Ms. Sharon Baker for doing the preliminary work on the project; Dr. -
Environmental Properties of Chemicals Volume 2
1 t ENVIRONMENTAL 1 PROTECTION Esa Nikunen . Riitta Leinonen Birgit Kemiläinen • Arto Kultamaa Environmental properties of chemicals Volume 2 1 O O O O O O O O OO O OOOOOO Ol OIOOO FINNISH ENVIRONMENT INSTITUTE • EDITA Esa Nikunen e Riitta Leinonen Birgit Kemiläinen • Arto Kultamaa Environmental properties of chemicals Volume 2 HELSINKI 1000 OlO 00000001 00000000000000000 Th/s is a second revfsed version of Environmental Properties of Chemica/s, published by VAPK-Pub/ishing and Ministry of Environment, Environmental Protection Department as Research Report 91, 1990. The pubiication is also available as a CD ROM version: EnviChem 2.0, a PC database runniny under Windows operating systems. ISBN 951-7-2967-2 (publisher) ISBN 952-7 1-0670-0 (co-publisher) ISSN 1238-8602 Layout: Pikseri Julkaisupalvelut Cover illustration: Jussi Hirvi Edita Ltd. Helsinki 2000 Environmental properties of chemicals Volume 2 _____ _____________________________________________________ Contents . VOLUME ONE 1 Contents of the report 2 Environmental properties of chemicals 3 Abbreviations and explanations 7 3.1 Ways of exposure 7 3.2 Exposed species 7 3.3 Fffects________________________________ 7 3.4 Length of exposure 7 3.5 Odour thresholds 8 3.6 Toxicity endpoints 9 3.7 Other abbreviations 9 4 Listofexposedspecies 10 4.1 Mammais 10 4.2 Plants 13 4.3 Birds 14 4.4 Insects 17 4.5 Fishes 1$ 4.6 Mollusca 22 4.7 Crustaceans 23 4.8 Algae 24 4.9 Others 25 5 References 27 Index 1 List of chemicals in alphabetical order - 169 Index II List of chemicals in CAS-number order -
Florida State Emergency Response Commission
Florida State Emergency Response Commission Sub-Committee on Training (SOT) HAZARDOUS MATERIALS MEDICAL TREATMENT PROTOCOLS Version 3.3 TOXIDROMES Toxidromes are clinical syndromes that the patient presents with. These patterns of signs and symptoms are essential for the successful recognition of chemical exposure. The toxidromes identified in this protocol are chemical exposure based while others such as the opioids are found within general medical protocol. These chemical toxidromes are identified clinically into five syndromes: Irritant Gas Toxidrome Asphyxiant Toxidrome Corrosive Toxidrome Hydrocarbon and Halogenated Hydrocarbons Toxidrome Cholinergic Toxidrome Each can present as a clinical manifestation of the chemical/poisoning involved with some cross-over between toxidromes. This list combines the toxic syndromes found within NFPA 473 (A.5.4.1(2) and traditional syndromes. Toxidrome Correlation to NFPA Standard 473 and Traditional Syndromes Toxidrome NFPA 473 A.5.4.1(2) Hazardous Materials Protocol Correlation Irritant Gas (j) Irritants Bronchospasm OC Pepper spray & lacrimants Asphyxiant (c) Chemical asphyxiants Carbon Monoxide (d) Simple asphyxiants Aniline dyes, Nitriles, Nitrares (h) Blood Agents Cyanide & Hydrogen Sulfide (n) Nitrogen Compounds Closed Space Fires Simple Asphyxants Corrosive (a) Corrosives Hydrofluroic Acid (g) Vesicants Chemical burns to the eye Choramine and Chlorine Hydrocarbon (e) Organic solvents Phenol and (q) Phenolic Compounds Halogenated Hydrocarbons Halogenated Hydrocarbons Cholinergic (b) Pesticides -
Organophosphate Poisoning : a Review
120 Sinha and Sharma Med J Indones Organophosphate poisoning : A review Parmod K. Sinha, Ashok Sharma Abstrak Pestisida organofosfat digunakan secara luas di seluruh dunia. Keracunan oleh bahan ini merupakan masalah kesehatan masyarakat, terutama di negara berkembang. Zat neurotoksik organofosfat merupakan bahan yang dianggap mengancam dalam bidang militer dan terorisme. Mekanisme toksisitas bahan ini adalah dengan cara menghambat asetilkolinesterase yang mengakibatkan menumpuknya neurotransmitor asetilkolin dan terjadi rangsangan terus-menerus pada reseptor asetilkolin pada sistem saraf sentral maupun perifer. Selain krisis kolinergik, organofosfat dapat menimbulkan berbagai sindrom neurologis, baik akut maupun kronik. Sedangkan gejala peralihan ( intermediate) terjadi 1-4 hari setelah krisis kolinergik teratasi. Pengobatan standar terdiri dari reaktivasi asetilkolinesterase dengan antidot golongan oksim (prolidoksim, oksidoksime, HI-6 dan HLo7), dan pengendalian efek biokimia asetilkolin dengan menggunakan atropin. Golongan oksim yang baru HI-6 dan Hlo7 merupakan reaktivator asetilkolinesterase yang lebih cocok dan efektif untuk keracunan akut dan berat dibandingkan dengan prolidoksim dan obidoksim. Penderita yang mendapat pengobatan segera, biasanya dapat sembuh dari toksisitas akut, namun gejala neurologis ikutan dapat saja terjadi. (Med J Indones 2003; 12: 120-6) Abstract Organophosphate pesticides are used extensively worldwide, and poisoning by these agents, particularly in developing nations is a public health problem. Organophosphorous -
Veterinary Toxicology
GINTARAS DAUNORAS VETERINARY TOXICOLOGY Lecture notes and classes works Study kit for LUHS Veterinary Faculty Foreign Students LSMU LEIDYBOS NAMAI, KAUNAS 2012 Lietuvos sveikatos moksl ų universitetas Veterinarijos akademija Neužkre čiam ųjų lig ų katedra Gintaras Daunoras VETERINARIN Ė TOKSIKOLOGIJA Paskait ų konspektai ir praktikos darb ų aprašai Mokomoji knyga LSMU Veterinarijos fakulteto užsienio studentams LSMU LEIDYBOS NAMAI, KAUNAS 2012 UDK Dau Apsvarstyta: LSMU VA Veterinarijos fakulteto Neužkre čiam ųjų lig ų katedros pos ėdyje, 2012 m. rugs ėjo 20 d., protokolo Nr. 01 LSMU VA Veterinarijos fakulteto tarybos pos ėdyje, 2012 m. rugs ėjo 28 d., protokolo Nr. 08 Recenzavo: doc. dr. Alius Pockevi čius LSMU VA Užkre čiam ųjų lig ų katedra dr. Aidas Grigonis LSMU VA Neužkre čiam ųjų lig ų katedra CONTENTS Introduction ……………………………………………………………………………………… 7 SECTION I. Lecture notes ………………………………………………………………………. 8 1. GENERAL VETERINARY TOXICOLOGY ……….……………………………………….. 8 1.1. Veterinary toxicology aims and tasks ……………………………………………………... 8 1.2. EC and Lithuanian legal documents for hazardous substances and pollution ……………. 11 1.3. Classification of poisons ……………………………………………………………………. 12 1.4. Chemicals classification and labelling ……………………………………………………… 14 2. Toxicokinetics ………………………………………………………………………...………. 15 2.2. Migration of substances through biological membranes …………………………………… 15 2.3. ADME notion ………………………………………………………………………………. 15 2.4. Possibilities of poisons entering into an animal body and methods of absorption ……… 16 2.5. Poison distribution -
Rapid HPLC Determination of Carbofuran and Carbaryl in Tap and Environmental Waters Using On-Line SPE
Application Update: 186 Rapid HPLC Determination of Carbofuran and Carbaryl in Tap and Environmental Waters Using On-Line SPE Xu Qun1 and Jeff Rohrer2 1Shanghai, Peoples Republic of China; 2Sunnyvale, CA, USA Introduction Method detection limits (MDLs) of the two Key Words N-methylcarbamates are widely used agricultural compounds were both ≤ 0.062 μg/L, which is lower than pesticides. Reversed-phase high-performance liquid the MDLs reported in EPA Method 8318 (2.0 μg/L for • Carbamates chromatography (RP-HPLC) with fluorescence detection carbofuran and 1.7 μg/L for carbaryl), and in the standard • U.S. EPA following postcolumn derivatization, per EPA Methods method enacted by the Chinese government (7 μg/L 531.2 and 8318,1,2 is the method typically used for the for carbofuran).5 The MDLs were also similar to those • Pesticides sensitive determination of carbamates. Thermo Scientific reported in EPA Method 531.2 (0.058 μg/L for carbofuran • Drinking Water has published a detailed method3,4 that is consistent with and 0.068 μg/L for carbaryl). The MDL for carbofuran is the EPA methods. When an HPLC with UV absorbance well under the 40 μg/L maximum allowable concentration • SolEx HRP detection method is used, a sample preparation in U.S. drinking water,6 and meets the general rule for • RSLC procedure—either liquid-liquid extraction or off-line pesticides in drinking water (98/83/EC) published by the solid-phase extraction (SPE)—is required to increase the European Union (the maximum admissible concentration detection sensitivity. However, these procedures are time- of each individual pesticide component is 0.1 μg/L).7 consuming, require large volumes of organic solvents, and Therefore this method would be universally appropriate are deficient in terms of process control. -
2018 Treated Water Undetected Chemical Contaminant List
2018 Treated Water Undetected Chemical Contaminant List ESTROGENS AND OTHER HORMONES Diethylstilbestrol (DES) Estrone 17alpha-Estradiol 17alpha-Ethynal estradiol 17beta-Estradiol Progesterone Estriol cis-Testosterone trans-Testosterone INORGANIC CHEMICALS Antimony Niobium Arsenic Osmium Beryllium Palladium Cadmium Platinum Cerium Praseodymium Cesium Rhenium Cobalt Rhodium Cyanide Ruthenium Dysprosium Samarium Erbium Selenium Europium Silver Gadolinium Tantalum Gallium Tellurium Germanium Thallium Gold Thorium Hafnium Thulium Holmium Tin Iridium Titanium Lanthanum Tungsten Lead Uranium Lutetium Vanadium Mercury Ytterbium Molybdenum Zinc Neodymium Zirconium Nickel NITROSAMINES N-Nitropyrrolidine (NPYR) N-Nitrosomorpholine (NMOR) N-Nitrosodi-N-butylamine (NDBA) N-Nitrosodiphenylamine (NDPhA) N-Nitrosodiethylamine (NDEA) N-Nitrosodi-N-propylamine (NDPA) N-Nitrosodimethylamine (NDMA) N-Nitrosomethylethylamine (NMEA) N-Nitrosopiperidine (NPIP) 1 ORGANIC CHEMICALS Acenaphthene Butylbenzylphthalate Acenaphthylene Butyraldehyde (Butanal) Acetaldehyde Carbaryl Acetochlor Carbofuran Acetone Carbon disulfide Acrylamide Carbophenothion Acrylonitrile Carbon tetrachloride Alachlor Carboxin Aldicarb (Temik) Chlordane Aldicarb sulfone Chlordane, alpha Aldicarb sulfoxide Chlordane, gamma Aldrin Chlorfenvinphos Allyl chloride Chloroacetonitrile Tert-Amyl Methyl ether Chlorobenzene Ametryn Chlorobenzilate Anilizine 2-Chlorobiphenyl Anthracene 1-Chlorobutane Aspon Chloroethane Atraton Chloromethane Atrazine Chloroneb Azinphos-ethyl Chloroprene Azinphos-methyl