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ISSN 1392-0138 (print) ISSN 2029-4174 (online) LITHUANIAN ACADEMY OF SCIENCES LIETUVOS MOKSLŲ AKADEMIJA Acta medica Lituanica The issue has been compiled in cooperation with the Faculty of Medicine of Vilnius University and the National Cancer Institute Leidinys sudarytas bendradarbiaujant su Vilniaus universiteto Medicinos fakultetu ir Nacionaliniu vėžio institutu Supplement to Volume 25. 2018 LIETUVOS MOKSLŲ AKADEMIJA Vilnius – 2018 Acta medica Lituanica, ISSN 1392–0138 (print), ISSN 2029-4174 (online) Journal of the Lithuanian Academy of Sciences Published since 1994 one volume (4 issues) per year. Fully peer-reviewed Types of contribution: Review articles – Original papers – Preli minary notes – Case reports – Short commu ni cations – Book reviews Editor-in-Chief Vice-editors Vytautas BASYS Zita Aušrelė KUČINSKIENĖ Lithuanian Academy of Sciences, Vilnius; Faculty of Medicine, Vilnius University, Lithuania Faculty of Medicine, Vilnius University, Lithuania (biochemical sciences, clinical medicine, laboratory medicine) Mailing address: Janina TUTKUVIENĖ Lithuanian Academy of Sciences Vilnius University, Lithuania Gedimino pr. 3, 01103 Vilnius, Lithuania (anthropology) Email: [email protected] Managing Editor Rūta BRIEDIENĖ National Cancer Institute (radiology) Santariškių 1, 08660 Vilnius, Lithuania Tel.: +370 614 97822, +370 5 278 6784 Email: [email protected] Editorial Board Virginijus ŠIKŠNYS, Institute of Biotechnology, Academy of Sciencies, Lithuania (biochemistry, molecular biology, biotechnology) Algirdas JUOZULYNAS, Lithuanian Assotiation of Ergonomics, Lithuania (experimental medicine, public health) Zygmunt MACKIEWICZ, Opole University, Poland (histology, cell biology) Narimantas SAMALAVIČIUS, National Cancer Institute, Lithuania (oncology) Editorial Council Arvydas AMBROZAITIS, Clinic of Infectious Diseases and Micro biology of Vilnius University, Lithuania (infectious diseases, virology) Jacek BOMBA, Jagiellonian University, Collegium Medicum, Cracow, Poland (psychiatry) Andrew BUSH, Royal Brompton Hospital, London, UK (pediatrics) Christian CABROL, Group Hospitalier Pitié-Salpetriere, Paris, France (cardiology) Gražina DRĄSUTIENĖ, Vilnius University, Lithuania (obstetrics, gynecology) Rūta DUBAKIENĖ, Vilnius University, Lithuania (allergology) Arūnas GASPARAITIS, University of Chicago Medical Center, U.S.A. (radiology) Per-Olof GLANTZ, Lund University, Malmö, Sweden (chemistry, prosthetic dentistry) Stefan GRAVENSTEIN, Glennan Centre for Geriatrics and Gerontology, U.S.A. (geriatrics, gerontology) Ričardas JANILIONIS, Vilnius University Hospital, Lithuania (thoracic surgery) Dalius JATUŽIS, Vilnius University, Lithuania (neurology) Jan KOWALSKI, Lodz University, Poland (dentistry) Vaidutis KUČINSKAS, Faculty of Medicine, Vilnius University, Lithuania (genetics) Linas KUPČINSKAS, Lithuanian University of Health Sciences, Lithuania (gastroenterology) Peter MALFERTHEINER, Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-v.-Guericke-University, Magdeburg, Germany (gastroenterology) Anders G. OLSSON, Institute för Internmedicin, Linköping, Sweden (biochemistry) Vytautė PEČIULIENĖ, Vilnius University, Lithuania (odontology) A n d r e w P. READ, Department of Medical Genetics, St. Mary’s Hospital, Manchester, U. K. (genetics) Francis ROBICZEK, Charlotte Medical Center, N. Carolina, U.S.A. (cardiology, cardiosurgery) Albert SCHINZEL, Institut für Medizinische Genetik, Zürich Universität, Switzerland (genetics) Jaroslav SPATENKA, Transplant Centre, University Hospital Motol, Prague, Czech Republic (transplantology) Rimantas STUKAS, Vilnius University, Lithuania (public health) Jūratė ŠIPYLAITĖ, Vilnius University, Lithuania (anaesthesiology) Vytas TAMOŠIŪNAS, State Research Institute, Centre for Innovative Medicine, Lithuania (immunology) Arūnas VALIULIS, Vilnius University, Lithuania (pediatrics) Konstantinas Povilas VALUCKAS, National Cancer Institute, Lithuania (oncology) Algirdas VENALIS, State Research Institute, Centre for Innovative Medicine, Lithuania (rheumatology) Dharmapuri VIDYASAGAR, Pediatrics University of Illinois, Chicago, U.S.A. (pediatrics) Zbigniew Feliks ZAGORSKI, Lublin University School of Medicine, Poland (ophthalmology) Remigijus ŽALIŪNAS, Lithuanian University of Health Sciences, Lithuania (cardiology) 2018 05 23 Indexed in PubMed, Index Copernicus, Index Academicus, EBSCO (www.epnet.com, Academic Search Complete) 11,5 sp. l. Tiražas 250 egz. Published by the Lithuanian Academy of Sciences Užsakymas Nr. 4411 Gedimino pr. 3, 01103 Vilnius, Lithuania, tel. +370 5 261 3620 Leidžia Lietuvos mokslų akademija, Editor- Diana BARTKUTĖ BARNARD Gedimino pr. 3, 01103 Vilnius Layout design Dainius MILIAUSKAS Spausdino UAB „BMK Leidykla“, Email: [email protected] J. Jasinskio 16, 03163 Vilnius Website: www.lmaleidykla.lt/actamedicalituanica/ © Lietuvos mokslų akademija, 2018 KETVIRTOJI TARPTAUTINĖ KONFERENCIJA Skirta Lietuvos nepriklausomybės atkūrimo 100-mečiui 2018 m. birželio mėn. 5–10 d. d., Vilniaus universitetas, Vilnius, LIETUVA EVOLIUCINĖ MEDICINA: SVEIKATA IR LIGOS BESIKEIČIANČIOJE APLINKOJE Rengėjas – Vilniaus universiteto Medicinos fakultetas FOURTH INTERNATIONAL CONFERENCE Dedicated to the 100th Anniversary of the Restoration of Lithuania’s Independence 5–10 June 2018, Vilnius University, Vilnius, LITHUANIA EVOLUTIONARY MEDICINE: HEALTH AND DISEASES IN CHANGING ENVIRONMENT Organized by the Faculty of Medicine, Vilnius University INTERNATIONAL SCIENTIFIC COMMITTEE Vytautas BASYS (Vilnius, Lithuania) Jonas BUNIKIS (Brussels, Belgium) Douglas E. CREWS (Columbus OH, USA) Elena GODINA (Moscow, Russia) Michael HERMANUSSEN (Aschauhof, Germany) Rimantas JANKAUSKAS (Vilnius, Lithuania) Sylvia KIRCHENGAST (Vienna, Austria) Sławomir KOZIEŁ (Wrocław, Poland) Marius MIGLINAS (Vilnius, Lithuania) Sasa MISSONI (Zagreb, Croatia) Martin MUSALEK (Praha, Czech Republic) Dario PIOMBINO-MASCALI (Vilnius, Lithuania) Frank RÜHLI (Zurich, Switzerland) Wulf SCHIEFENHÖVEL (Andechs-Seewiesen, Germany) Janina TUTKUVIENĖ (Vilnius, Lithuania) Algirdas UTKUS (Vilnius, Lithuania) Marian VANHAEREN (Bordeaux, France) Inês VARELA-SILVA (Loughborough, UK) Albert ZINK (Bolzano, Italy) LOCAL ORGANIZING COMMITTEE Chair Janina TUTKUVIENĖ (Faculty of Medicine, Vilnius University) Conference Secretary Eglė Marija JAKIMAVIČIENĖ (Faculty of Medicine, Vilnius University) Members Arūnas BARKUS (Faculty of Medicine, Vilnius University) Rima DAUNORAVIČIENĖ (Faculty of Medicine, Vilnius University) Samanta GRUBYTĖ (Faculty of Medicine, Vilnius University) Viktorija GURSKYTĖ (Faculty of Medicine, Vilnius University) Mantas MINSEVIČIUS (Faculty of Medicine, Vilnius University) Laura NEDZINSKIENĖ (Faculty of Medicine, Vilnius University) Dominykas STANKEVIČIUS (Faculty of Medicine, Vilnius University) Andrej SUCHOMLINOV (Faculty of Medicine, Vilnius University) Lukas ŠALAŠEVIČIUS (Faculty of Medicine, Vilnius University) Renata ŠIMKŪNAITĖ-RIZGELIENĖ (Faculty of Medicine, Vilnius University) Violeta ŽALGEVIČIENĖ (Faculty of Medicine, Vilnius University) Dear Colleagues, It is with a great pleasure that we welcome you to the Fourth International Confer- ence Evolutionary Medicine: Health and Diseases in Changing Environment dedicat- ed to the 100th anniversary of the restoration of Lithuania’s Independence. We kindly invite PhD students and their supervisors, other junior and senior scientists, medical residents, and undergraduate students from different fields of research to take part at this international interdisciplinary scientific event, which will be held at the Old Cam- pus of Vilnius University from the 5th to the 10th of June 2018. Special focus will be placed on worldwide changes in the human body, the general health status, and diseas- es during the last 100 years. Conferences on Evolutionary medicine have been organized at Vilnius University biannually since 2012. Evolutionary thinking for medical students at Vilnius Universi- ty has been implemented since the 1960s–1970s by the anatomist and anthropologist Professor Salezijus Pavilonis. However, stressing the importance of the evolutionary approach while judging about health and disease grew steadily and was launched via collaboration with Professor Wulf Schiefenhövel from Max Planck Institute in Ger- many. The present Conference will bring together participants from different areas of research (medicine, anthropology, biology, psychology, physical sciences, and others) to discuss changes in the general health status and diseases in relation to different envi- ronments, and to deeper fathom out the evolutionary mechanisms of current diseases. Keynote speakers from Austria, Belgium, the Czech Republic, Croatia, France, Germa- ny, Great Britain, Italy, Lithuania, Poland, Russia, Switzerland, and the USA will share their experience and knowledge with young and established scientists. During the last hundred years, the accumulation of scientific knowledge led to in- creasing specialization by fragmenting many research fields into smaller and rather narrow disciplines or sub-disciplines in order to gain a thorough understanding of many scientific questions. Due to rapid technical advances, biomedical science has de- veloped at an unprecedented stride as well. For many years, biomedical research was carried out mainly within the boundaries of one department (a multidisciplinary ap- proach to many research problems prevailed). Today, however, the development of new methods, the abundance of scientific knowledge, and the needs for high expertise in different fields
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    SZYMON DREJ Bohater dwóch narodów Dviejų tautų didvyris The Hero of Two Nations SZYMON DREJ Bohater dwóch narodów Dviejų tautų didvyris The Hero of Two Nations Projekt „Śladami księcia Witolda” Nr SPF/PL/2009/45 jest wdrażany w ramach Celu 3: EuropejskaWspółpraca Terytorialna Program Współpracy Transgranicznej „Litwa-Polska”, który ma na celu wspieranie zrównoważonego rozwoju obszaru przygranicznego Litwy i Polski, poprzez podniesienie ekonomicznej, społecznej i terytorialnej spójności. Program jest współfinansowany z Europejskiego Funduszu Rozwoju Regionalnego. Leidinys parengtas pagal projektą „Didžiojo kunigaikščio Vytauto pėdomis“ Nr. SPF/PL/2009/45 vykdomą pagal Europos teritorinio bendradarbiavimo tikslo Lietuvos ir Lenkijos bendradarbiavimo per sieną programos Smulkiųjų projektų fondą, skirtą skatinti tvarų Lietuvos ir Lenkijos pasienio regiono vystymąsi didinant ekonominę, socialinę ir teritorinę sanglaudą. Programą iš dalies finansuoja Europos Sąjungos Europos regioninės plėtros fondas. The publication has been prepared under the project “The Traces of Grand Duke Vytautas” No. SPF/PL/2009/45 is implemented under the Objective 3: European Territorial Cooperation Cross-Border Cooperation Programme “Lithuania-Poland”, which aims at fostering the sustainable development of the Lithuania-Poland border region through enhanced economic, social and territorial cohesion. The programme is part-financed by the European Union European Regional Development Fund. EUROPEAN UNION EUROPEAN REGIONAL DEVELOPMENT FUND NEIGHBOURS IN ACTION SMALL