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Download Download JOURNAL OF THE ITALIAN SOCIETY OF ANATOMIC PATHOLOGY AND DIAGNOSTIC CYTOPATHOLOGY, ITALIAN DIVISION OF THE INTERNATIONAL ACADEMY OF PATHOLOGY Periodico trimestrale - Aut. Trib. di Genova n. 75 del 22/06/1949 ISSN: 1591-951X (Online) The GIPAD handbook of the gastrointestinal pathologist (in the Covid-19 era) - Part I 03VOL. 112 Edited by Paola Parente and Matteo Fassan SEPTEMBER 2020 Editor-in-Chief C. Doglioni G. Pelosi M. Barbareschi San Raffaele Scientific Institute, Milan University of Milan Service of Anatomy and M. Fassan F. Pierconti University of Padua Pathological Histology, Trento Catholic University of Sacred G. Fornaciari Heart, Rome Associate Editor University of Pisa M. Chilosi M.P. Foschini S. Pileri Department of Pathology, Verona Bellaria Hospital, Bologna Milano European Institute of University, Verona G. Fraternali Orcioni Oncology, Milan S. Croce e Carle Hospital, Cuneo 03Vol. 112 P. Querzoli Managing Editor E. Fulcheri St Anna University Hospital, Ferrara University of Genoa September 2020 P. N oz za L. Resta M. Guido Pathology Unit, Ospedali Galliera, University of Bari Genova, Italy University of Padua S. Lazzi G. Rindi Catholic University of Sacred Italian Scientific Board University of Siena L. Leoncini M. Brunelli Heart, Rome University of Siena E.D. Rossi University of Verona C. Luchini G. Bulfamante Catholic University of Sacred University of Verona University of Milano G. Magro Heart, Rome G. Cenacchi University of Catania A.G. Rizzo University of Bologna E. Maiorano “Villa Sofia-Cervello” Hospital, C. Clemente University of Bari Aldo Moro Palermo San Donato Hospital, Milano A. Marchetti G. Rossi M. Colecchia University of Chieti-Pescara Hospital S. Maria delle Croci, IRCCS National Cancer Institute, G. Marucci Azienda Romagna, Ravenna Milan Bellaria Hospital, Bologna P. Cossu-Rocca G. Martignoni G. Santeusanio University of Sassari IRCCS Sacro Cuore Don Calabria University of Rome “Tor Vergata G. d’Amati Hospital, Negrar, Verona L. Saragoni Sapienza University of Rome G. Negri Morgagni-Pierantoni Hospital, Forlì E. d’Amore Pathology Unit Central Hospital G. Tallini San Bortolo Hospital, Vicenza Bolzano University of Bologna A. D’Errico A. Orlandi L. Ventura S. Orsola-Malpighi Hospital, University of Rome “Tor Vergata” University of Bologna M. Paulli San Salvatore Hospital, L’Aquila P.A. Dei Tos University of Pavia; IRCCS San G. Zamboni University of Padua Matteo Hospital Foundation, Pavia University of Verona International Scientific Board Governing Board SIAPEC-IAP R. Alaggio President: Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, USA A. Sapino G. Bhagat University of Torino Columbia University, New York, USA Past President: A. Capitanio M. Truini Linköping University Hospital, Likping, Sweden Niguarda Cancer Center, Ospedale Niguarda Ca’ Granda, Milan T.V. Colby Mayo Clinic Scottsdale, AZ, USA President Elect: G. Cserni F. Fraggetta University of Szeged, Szeged, Hungary Cannizzaro Hospital, Catania, Italy S. Di Palma General Secretary: Royal Surrey County Hospital, Guilford, UK E. Bonoldi J. Fukuoka Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan Nagasaki University, Nagasaki, Japan Councillors: C. Giannini E. Bonoldi Department of Laboratory Medicine and Pathology Mayo Clinic Rochester, Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan MN, USA E. Fulcheri J. Kulka University of Genoa Semmelweis University, Budapest, Hungary A. Parafioriti T. Mentzel Gaetano Pini Hospital, Milan Dermatopathology Bodensee, Friedrichshafen, Baden-Württemberg Germany G.F. Zannoni M. Mihm Catholic University of Sacred Heart, Rome Brigham and Women’s Hospital, Harvard Medical School, Boston, Massa- chusetts, USA Representative L. Pantanowitz University/IRCCS: University of Pittsburgh Medical Center, Pittsburgh, PA, USA E. Maiorano M. Reyes-Múgica University of Bari UPMC Children’s Hospital of Pittsburgh; University of Pittsburgh School of Hospital/Individuals Medicine, Pittsburgh, PA, USA L. Molinaro F. Roncaroli City of Health and Science, Turin Imperial College of London, UK A. Skálová Junior counsellor: Charles Univesity, Plzen, Czech Republic V. L’Imperio M. Smith San Gerardo Hospital, University of Milano-Bicocca, Monza Mayo Clinic Scottsdale, AZ, USA Citology Board: S. Suster G. Fadda Medical College Wisconsin, Milwaukee, WI, USA Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome Y. Zen G. Negri King’s College Hospital & King’s College London, UK Central Hospital Bolzano Coord. National Council: Editorial Secretariat M. Guido F. Pedica University of Padua School of Medicine San Raffaele Scientific Institute, Milan L. Saragoni Morgagni-Pierantoni Hospital, Forlì F. Tallarigo Public Health Unit, COR Calabria, Crotone APOF Representative: G. Dell’Antonio San Raffaele Scientific Institute, Milan AITIC Representative: Moris Cadei ASST Spedali Civili-Unibs, Brescia Copyright Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology Publisher Pacini Editore S.r.l. Via Gherardesca, 1 56121 Pisa, Italy Tel. +39 050 313011 Fax +39 050 3130300 [email protected] www.pacinimedicina.it CONTENTS PATHOLOGICA 03 September 2020 EDITORIAL The GIPAD handbook of the gastrointestinal pathologist (in the Covid-19 era) P. Parente, S. Battista, E. Unti, A. D’Amuri, A. Vanoli, L. Mastracci, M. Fassan .........................................................................................115 REVIEWS Gastro-esophageal reflux disease and Barrett’s esophagus: an overview with an histologic diagnostic approach L. Mastracci, F. Grillo, P. Parente, E. Unti, S. Battista, P. Spaggiari, M. Campora, G. Scaglione, M. Fassan, R. Fiocca ..............................117 Non gastro-esophageal reflux disease related esophagitis: an overview with a histologic diagnostic approach L. Mastracci, F. Grillo, P. Parente, E. Unti, S. Battista, P. Spaggiari, M. Campora, L. Valle, M. Fassan, R. Fiocca ......................................128 Neoplastic and pre-neoplastic lesions of the oesophagus and gastro-oesophageal junction F. Grillo, L. Mastracci, L. Saragoni, A. Vanoli, F. Limarzi, I. Gullo, J. Ferro, M. Paudice, P. Parente, M. Fassan .........................................138 Gastritis: update on etiological features and histological practical approach G. Pennelli, F. Grillo, F. Galuppini, G. Ingravallo, E. Pilozzi, M. Rugge, R. Fiocca, M. Fassan, L. Mastracci ................................................153 Precancerous lesions of the stomach, gastric cancer and hereditary gastric cancer syndromes I. Gullo, F. Grillo, L. Mastracci, A. Vanoli, F. Carneiro, L. Saragoni, F. Limarzi, J. Ferro, P. Parente, M. Fassan ..........................................166 Celiac disease: histology-differential diagnosis-complications. A practical approach V. Villanacci, A. Vanoli, G. Leoncini, G. Arpa, T. Salviato, L. Reggiani Bonetti, C. Baronchelli, L. Saragoni, P. Parente ..............................186 Inflammatory and tumor-like lesions of the pancreas C. Luchini, M. Fassan, C. Doglioni, P. Capelli, G. Ingravallo, G. Renzulli, S. Pecori, G. Paolino, A.M. Florena, A. Scarpa, G. Zamboni ..............................................................................................................................................................................197 Malignant epithelial/exocrine tumors of the pancreas C. Luchini, F. Grillo, M. Fassan, A. Vanoli, P. Capelli, G. Paolino, G. Ingravallo, G. Renzulli, C. Doglioni, A. D’Amuri, P. Mattiolo, S. Pecori, P. Parente, A.M. Florena, G. Zamboni, A. Scarpa ....................................................................................................210 Gastrointestinal lymphoproliferative lesions: a practical diagnostic approach M. Pizzi, E. Sabattini, P. Parente, A. Bellan, C. Doglioni, S. Lazzi ...............................................................................................................227 Current prognostic and predictive biomarkers for gastrointestinal tumors in clinical practice M. Fassan, A. Scarpa, A. Remo, G. De Maglio, G. Troncone, A. Marchetti, C. Doglioni, G. Ingravallo, G. Perrone, P. Parente, C. Luchini, L. Mastracci ...........................................................................................................................................................248 Front cover: Different sampling techniques for duodeno-pancreatic head resections. Margins are inked indifferent colors: green - anterior surface; blue - superior mesenteric vein groove; red - uncinate process/ medial/retroperitoneal/superior mesenteric artery margin; black (minimum portion shown) - posterior surface. (page 212). PATHOLOGICA 2020;112:115-116; DOI: 10.32074/1591-951X-160 Editorial The GIPAD handbook of the gastrointestinal pathologist (in the Covid-19 era) Paola Parente1, Serena Battista2, Elettra Unti3, Alessandro D’Amuri4, Alessandro Vanoli5,6, Luca Mastracci7,8, Matteo Fassan9 1 Pathology Unit, Fondazione IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy; 2 SOC di Anatomia Patologica, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy; 3 UOC Anatomia Patologica, ARNAS Ospedali Civico-Di Cristina-Benfratelli, Palermo, Italy; 4 Anatomic Pathology Unit, “A. Perrino” Hospital, Brindisi, Italy; 5 Anatomic Pathology Unit, Department of Molecular Medicine, University of Pavia, Italy; 6 IRCCS San Matteo Hospital, Pavia, Italy; 7 Anatomic Pathology, Ospedale Policlinico San Martino IRCCS, Genova, Italy;
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