Kaplan USMLE Step 2 CK Surgery Lecture Notes2018

Total Page:16

File Type:pdf, Size:1020Kb

Kaplan USMLE Step 2 CK Surgery Lecture Notes2018 USMLE ® • UP-TO-DATE ® STEP 2 CK STEP Updated annually by Kaplan’s all-star faculty STEP2 CK • INTEGRATED Lecture Notes 2018 Notes Lecture Packed with bridges between specialties and basic science Lecture Notes 2018 • TRUSTED Used by thousands of students each year to ace the exam USMLE Surgery Surgery Tell us what you think! Visit kaptest.com/booksfeedback and let us know about your book experience. ISBN: 978-1-5062-2822-8 kaplanmedical.com 9 7 8 1 5 0 6 2 2 8 2 2 8 USMLE® is a joint program of The Federation of State Medical Boards of the United States, Inc. and the National Board of Medical Examiners. USMLE® is a joint program of the Federation of State Medical Boards (FSMB) and the National Board of Medical Examiners (NBME), neither of which sponsors or endorses this product. 978-1-5062-2822-8_USMLE_Step2_CK_Surgery_Course_CVR.indd 1 6/21/17 10:58 AM ® STEP 2 CK Lecture Notes 2018 USMLE Surgery USMLE® is a joint program of The Federation of State Medical Boards of the United States, Inc. and the National Board of Medical Examiners. S2 Surgery.indb 1 6/20/17 9:15 AM USMLE® is a joint program of the Federation of State Medical Boards (FSMB) and the National Board of Medical Examiners (NBME), neither of which sponsors or endorses this product. This publication is designed to provide accurate information in regard to the subject matter covered as of its publication date, with the understanding that knowledge and best practice constantly evolve. The publisher is not engaged in rendering medical, legal, accounting, or other professional service. If medical or legal advice or other expert assistance is required, the services of a competent profes- sional should be sought. This publication is not intended for use in clinical practice or the delivery of medical care. To the fullest extent of the law, neither the Publisher nor the Editors assume any liability for any injury and/or damage to persons or property arising out of or related to any use of the material contained in this book. © 2017 by Kaplan, Inc. Published by Kaplan Medical, a division of Kaplan, Inc. 750 Third Avenue New York, NY 10017 All rights reserved. The text of this publication, or any part thereof, may not be reproduced in any manner whatsoever without written permission from the publisher. 10 9 8 7 6 5 4 3 2 1 Course ISBN: 978-1-5062-2822-8 Retail Kit ISBN: 978-1-5062-2088-8 This item comes as a set and should not be broken out and sold separately. Kaplan Publishing print books are available at special quantity discounts to use for sales promotions, employee premiums, or educational purposes. For more information or to purchase books, please call the Simon & Schuster special sales department at 866-506-1949. USMLE® is a joint program of The Federation of State Medical Boards of the United States, Inc. and the National Board of Medical Examiners. S2 Surgery.indb 2 6/20/17 9:15 AM Editors Carlos Pestana, M.D., Ph.D. Emeritus Professor of Surgery University of Texas Medical School at San Antonio San Antonio, TX Adil Farooqui, M.D., F.R.C.S. Clinical Assistant Professor of Surgery Keck School of Medicine, University of Southern California Kaiser Permanente, West Los Angeles Medical Center Los Angeles, CA Mark Nolan Hill, M.D., F.A.C.S. Professor of Surgery Chicago Medical School Chicago, IL Contributor Ted A. James, M.D., M.S., F.A.C.S. Chief, Breast Surgical Oncology Vice Chair, Academic Affairs Department of Surgery Beth Israel Deaconess Medical Center Harvard Medical School Boston, MA The editors wish to also acknowledge Gary Schwartz, M.D., Baylor University Medical Center. USMLE® is a joint program of The Federation of State Medical Boards of the United States, Inc. and the National Board of Medical Examiners. S2 Surgery.indb 3 6/20/17 9:15 AM We want to hear what you think. What do you like or not like about the Notes? Please email us at [email protected]. USMLE® is a joint program of The Federation of State Medical Boards of the United States, Inc. and the National Board of Medical Examiners. S2 Surgery.indb 4 6/20/17 9:15 AM Table of Contents Part I. Surgery Chapter 1. Trauma...................................................... 3 Chapter 2. Orthopedics.................................................. 19 Chapter 3. Pre-Op and Post-Op Care ..................................... .35 Chapter 4. General Surgery ............................................. .45 Chapter 5. Pediatric Surgery............................................. 65 Chapter 6. Cardiothoracic Surgery ........................................ 71 Chapter 7. Vascular Surgery ............................................. 75 Chapter 8. Skin Surgery ................................................ .79 Chapter 9. Ophthalmology............................................... 81 Chapter 10. Otolaryngology (ENT) ....................................... .83 Chapter 11. Neurosurgery .............................................. .87 Chapter 12. Urology .................................................... 91 Chapter 13. Organ Transplantation ....................................... .95 USMLE® is a joint program of The Federation of State Medical Boards of the United States, Inc. and the National Board of Medical Examiners. v S2 Surgery.indb 5 6/20/17 9:15 AM USMLE Step 2 CK l Surgery Part II. Surgical Vignettes Chapter 1. Trauma..................................................... 99 Chapter 2. Orthopedics................................................. 131 Chapter 3. Pre-Op and Post-Op Care .................................... .149 Chapter 4. General Surgery ............................................ 163 Chapter 5. Pediatric Surgery............................................ 195 Chapter 6. Cardiothoracic Surgery ...................................... .201 Chapter 7. Vascular Surgery ............................................ 207 Chapter 8. Skin Surgery ............................................... .209 Chapter 9. Ophthalmology.............................................. 211 Chapter 10. Otolaryngology (ENT) ....................................... 215 Chapter 11. Neurosurgery .............................................. 221 Chapter 12. Urology .................................................. .229 Chapter 13. Organ Transplantation ...................................... 237 Index ..................................................................... .239 Additional resources available at www.kaptest.com/usmlebookresources USMLE® is a joint program of The Federation of State Medical Boards of the United States, Inc. and the National Board of Medical Examiners. vi S2 Surgery.indb 6 6/20/17 9:15 AM SECTIONPART I I Surgery USMLE® is a joint program of The Federation of State Medical Boards of the United States, Inc. and the National Board of Medical Examiners. S2 Surgery.indb 1 6/20/17 9:15 AM USMLE® is a joint program of The Federation of State Medical Boards of the United States, Inc. and the National Board of Medical Examiners. S2 Surgery.indb 2 6/20/17 9:15 AM Trauma Chapter Title 001 Learning Objectives ❏ List the ABCs of evaluating a trauma patient ❏ Demonstrate a head-to-toe review of a trauma patient ❏ Provide basic information about treatment of burns, bites, and stings PRIMARY SURVEY: THE ABCs Airway The first step in the evaluation of trauma is airway assessment and protection. • An airway is considered protected if the patient is conscious and speaking in a normal tone of voice. • An airway is considered unprotected if there is an expanding hematoma or subcutane- ous emphysema in the neck, noisy or “gurgly” breathing, or a Glasgow Coma Scale <8. An airway should be secured before the situation becomes critical. In the field, an airway can be secured by intubation or cricothyroidotomy. This is called a “definitive airway.” In the emergency department, it is best done by rapid sequence induction and orotracheal intuba- tion, with monitoring of pulse oximetry. In the presence of a cervical spine injury, orotracheal intubation can still be done as long as the head is secured and in-line stabilization is main- tained during the procedure. Another option in that setting is nasotracheal intubation over a fiberoptic bronchoscope. If severe maxillofacial injuries preclude the use of intubation or intubation is unsuccessful, cricothyroidotomy may become necessary. In the pediatric patient population (age <12), tracheostomy is preferred over cricothyroid- otomy due to the high risk of airway stenosis, as the cricoid is much smaller than in the adult. Breathing Breath sounds indicate satisfactory ventilation; an absence or decrease of breath sounds may indicate a pneumothorax and/or hemothorax and necessitate chest tube placement. Pulse oximetry indicates satisfactory oxygenation; hypoxia may be secondary to airway compro- mise, pulmonary contusion, or neurological injury impairing respiratory drive and necessitate intubation. Measurement of CO2 (capnography) is also very useful. USMLE® is a joint program of The Federation of State Medical Boards of the United States, Inc. and the National Board of Medical Examiners. 3 S2 Surgery.indb 3 6/20/17 9:15 AM USMLE Step 2 CK l Surgery Circulation Clinical signs of shock include the following: • Low BP (<90 mm Hg systolic) • Tachycardia (heart rate >100 bpm) • Low urinary output (<0.5 ml/kg/h) Patients in shock will be pale, cold, shivering, sweating, thirsty, and apprehensive. In the trauma setting, shock is either hypovolemic (secondary to hemorrhage and the most common scenario) or cardiogenic (secondary to pericardial tamponade or tension pneumo-
Recommended publications
  • Non-Hodgkin's Gastrointestinal Lymphoma Presenting As Acute
    Cirujano CLINICAL CASE General July-September 2019 Vol. 41, no. 3 / p. 208-216 Non-Hodgkin’s gastrointestinal lymphoma presenting as acute abdomen Linfoma no Hodgkin gastrointestinal presentándose como abdomen agudo CLINICAL CASES Arcenio Luis Vargas-Ávila,* Alan Hernández-Rosas,** José Roldán-Tinoco,*** Levi Alan Guzmán-Peña,*** Julián Vargas-Flores,**** Julio Adán Campos-Badillo,*** CASOS CLÍNICOS Rubén Mena-Maldonado***** Keywords: Lymphoma, small ABSTRACT RESUMEN intestine, hemorrhage, acute abdomen. Non-Hodgkin lymphoma is an uncommon cancer, but El linfoma no Hodgkin es una neoplasia poco común, when it is a primary lymphoma, the gastrointestinal tract pero cuando se trata de un linfoma primario, el tracto Palabras clave: is the most commonly involved and one of the most gastrointestinal es el sitio más comúnmente implicado y Linfoma, intestino common extra-nodal sites. Multiple risk factors have una de las presentaciones extranodales más frecuentes. delgado, hemorragia, been associated. However, its etiology is still unknown. Se han asociado múltiples factores de riesgo; sin embar- abdomen agudo. Nowadays there exist histochemical markers to distinguish go, aún se desconoce su etiología. Actualmente existen different cell types, criteria, and scales to differentiate marcadores histoquímicos que permiten diferenciar los between primary and secondary intestinal lymphomas. distintos tipos celulares así como los criterios y escalas The definitive diagnosis is obtained with a histopathologic para distinguir entre linfomas intestinales primarios y and immunohistochemical study of the extracted surgical secundarios. El diagnóstico definitivo se logra con el piece. Some studies such as endoscopy, CAT scan or estudio histopatológico e inmunohistoquímico de la pieza capsule endoscopy and double balloon enteroscopy have extraída quirúrgica o endoscópicamente.
    [Show full text]
  • Tumours of the Stomach Seen in Distal Disease, Whereas Diffuse Cancers Are Poorly Differentiated and Seen in Cardia Cancers
    OESOPHAGUS AND STOMACH Intestinal cancers are usually well differentiated and more often Tumours of the stomach seen in distal disease, whereas diffuse cancers are poorly differentiated and seen in cardia cancers. Metastatic spread is by William H Allum direct infiltration, via lymphatics to regional and distant lymph nodes, haematogenous and transcoelomic, spreading throughout body cavities. Nodal status is based on the Japanese classification Abstract of lymph node drainage, which is divided into three tiers that are e Gastric tumours are either epithelial or stromal in origin. Benign tumours related to the principal arterial supply to the stomach (N1 3, are rare with the majority being malignant and mostly adenocarcinomas. Table 2). Classification of nodal stage has been modified Gastric lymphomas, gastrointestinal stromal tumours (GISTs) and gastric according to the number of nodes involved in relation to the carcinoid are less common and have variable cancer biology. Gastric number of nodes resected. The TNM classification has recently e adenocarcinoma is the eighth-commonest cancer in the UK. Proximally been revised TNM 7. In the revision oesophageal cancer situated cancers are most frequent. It is characterized by late presentation includes all cancers within 5 cm of the squamo-columnar junc- with 80% of patients presenting with locally advanced or distant meta- tion. All other cancers are classified as gastric. This is a pathological static disease. Recognition of early gastric cancer remains a challenge classification which has been recommended for implementation by in low-incidence areas. Improvements in imaging techniques have allowed more individualized, tailored and stage-related treatments. Outcome in localized cancers has improved with multi-modality therapies yet overall survival remains poor.
    [Show full text]
  • Immunohistochemistry Stain Offerings
    immunohistochemistry stain offerings TRUSTED PATHOLOGISTS. INVALUABLE ANSWERS.™ MARCHMAY 20172021 www.aruplab.com/ap-ihcaruplab.com/ap-ihc InformationInformation in this brochurein this brochure is current is current as of as May of March 2021. 2017. All content All content is subject is subject to tochange. change. Please contactPlease ARUPcontact ClientARUP Services Client Services at 800-522-2787 at (800) 522-2787 with any with questions any questions or concerns.or concerns. ARUP LABORATORIES As a nonprofit, academic institution of the University of Utah and its Department We believe in of Pathology, ARUP believes in collaborating, sharing and contributing to laboratory science in ways that benefit our clients and their patients. collaborating, Our test menu is one of the broadest in the industry, encompassing more sharing and than 3,000 tests, including highly specialized and esoteric assays. We offer comprehensive testing in the areas of genetics, molecular oncology, pediatrics, contributing pain management, and more. to laboratory ARUP’s clients include many of the nation’s university teaching hospitals and children’s hospitals, as well as multihospital groups, major commercial science in ways laboratories, and group purchasing organizations. We believe that healthcare should be delivered as close to the patient as possible, which is why we support that provide our clients’ efforts to be the principal healthcare provider in the communities they serve by offering highly complex assays and accompanying consultative support. the best value Offering analytics, consulting, and decision support services, ARUP provides for the patient. clients with the utilization management tools necessary to prosper in this time of value-based care.
    [Show full text]
  • Download Download
    JOURNAL OF THE ITALIAN SOCIETY OF ANATOMIC PATHOLOGY AND DIAGNOSTIC CYTOPATHOLOGY, ITALIAN DIVISION OF THE INTERNATIONAL ACADEMY OF PATHOLOGY Periodico trimestrale - Aut. Trib. di Genova n. 75 del 22/06/1949 ISSN: 1591-951X (Online) The GIPAD handbook of the gastrointestinal pathologist (in the Covid-19 era) - Part I 03VOL. 112 Edited by Paola Parente and Matteo Fassan SEPTEMBER 2020 Editor-in-Chief C. Doglioni G. Pelosi M. Barbareschi San Raffaele Scientific Institute, Milan University of Milan Service of Anatomy and M. Fassan F. Pierconti University of Padua Pathological Histology, Trento Catholic University of Sacred G. Fornaciari Heart, Rome Associate Editor University of Pisa M. Chilosi M.P. Foschini S. Pileri Department of Pathology, Verona Bellaria Hospital, Bologna Milano European Institute of University, Verona G. Fraternali Orcioni Oncology, Milan S. Croce e Carle Hospital, Cuneo 03Vol. 112 P. Querzoli Managing Editor E. Fulcheri St Anna University Hospital, Ferrara University of Genoa September 2020 P. N oz za L. Resta M. Guido Pathology Unit, Ospedali Galliera, University of Bari Genova, Italy University of Padua S. Lazzi G. Rindi Catholic University of Sacred Italian Scientific Board University of Siena L. Leoncini M. Brunelli Heart, Rome University of Siena E.D. Rossi University of Verona C. Luchini G. Bulfamante Catholic University of Sacred University of Verona University of Milano G. Magro Heart, Rome G. Cenacchi University of Catania A.G. Rizzo University of Bologna E. Maiorano “Villa Sofia-Cervello” Hospital, C. Clemente University of Bari Aldo Moro Palermo San Donato Hospital, Milano A. Marchetti G. Rossi M. Colecchia University of Chieti-Pescara Hospital S.
    [Show full text]
  • Collision Tumors in the Gastrointestinal Tract: a Rare Case Series
    International Medical Case Reports Journal Dovepress open access to scientific and medical research Open Access Full Text Article CASE SERIES Collision tumors in the gastrointestinal tract: a rare case series Aruna Bhattacharya1 Abstract: A collision tumor is one where histology shows the presence of two distinct primaries Rama Saha1 involving the same organ without intermixture of individual cell types, ie, a side by side pattern. Jayanta Biswas2 Here we present three rare cases of collision tumors involving the stomach and transverse Jhuma Biswas1 colon. There were two cases of collision tumors involving the stomach, one of which was a Biswajit Ghosh1 combination of adenocarcinoma and low-grade non-Hodgkin’s (mucosa-associated lymphoid tissue) lymphoma, and the other showed the presence of non-Hodgkin’s lymphoma involving 1Institute of Postgraduate Medical the entire stomach wall along with adenocarcinoma infiltrating the muscle layer. The third case Education and Research, 2NRS Medical College and Hospital, comprised a mucinous adenocarcinoma and carcinoid tumor in the large gut. Kolkata, West Bengal, India Keywords: collision tumor, histology, gastrointestinal tract Cases 1 and 2 The coexistence of a gastric adenocarcinoma and a primary gastric lymphoma occurs rarely, as evidenced by the paucity of relevant case reports.1–4 However, there might be some causal relationship with infections caused by Helicobacter pylori and Epstein- Barr virus.3,5 Case 1 was a 55-year-old Indian man who presented with hematemesis and a sensation of fullness in the upper abdomen. On ultrasound there was gross thickening of the gastric wall along with enlarged gastric lymph nodes. The patient underwent total gastrectomy and esophagojejunostomy.
    [Show full text]
  • EPI-28-10-Highlights 1557..1557
    Cancer Epidemiology, Biomarkers & Prevention Highlights October 2019 * Volume 28 * Number 10 Selected Articles from This Issue Disparities in Cancer Incidence and Trends Among American Indians and Alaska Natives Melkonian et al. Page 1604 The American Indian and Alaska Native (AI/AN) population bears a disproportionate burden of cancer incidence in the United States. To describe cancer incidence rates and trends in the AI/AN population compared with the non-Hispanic white population, Melkonian and colleagues used data from the central cancer registries linked with the Indian Health Service patient registration databases to identify cancers diagnosed between 2010 and 2015. The authors reported elevated rates of lung, colorectal, liver, kidney, and stomach cancer in the AI/AN population that varied by geographic region. This confirmed widening cancer disparities and highlighted missed opportunities for targeted interventions to reduce AI/AN cancer incidence. Incidence and Incidence Trends and Urinary Metabolites Demographic Burden of Survival of Gastric Cancer in Diagnostic and Prognostic HPV-Positive Taiwan in the Era of H. pylori of Intrahepatic Oropharyngeal Head and Eradication Cholangiocarcinoma Neck Cancers in the U.S. Mahal et al. Page 1660 Chang et al. Page 1694 Haznadar et al. Page 1704 Over the last two decades, there has been a Helicobacter pylori (H. pylori) eradication The etiology of intrahepatic rise in head and neck cancers in the has been shown to decrease gastric cholangiocarcinoma (ICC) is less well- oropharynx, due to the human adenocarcinoma risk. The epidemiology known compared to hepatocellular papillomavirus (HPV). These cancers of gastric lymphoma, which is also carcinoma (HCC). As ICC has poor require aggressive treatment with radiation, associated with H.
    [Show full text]
  • Infection and Cancer: Global Distribution and Burden of Diseases Jin-Kyoung Oh, Phd, MPH, and Elisabete Weiderpass, Phd, MD
    STATE-OF-THE-ART REVIEW Infection and Cancer: Global Distribution and Burden of Diseases Jin-Kyoung Oh, PhD, MPH, and Elisabete Weiderpass, PhD, MD ABSTRACT Background: Infection is one of the main risk factors for cancer. Objectives: Epidemiology, pathogenesis, and disease burden of infection-related cancers were reviewed by infectious agents. Findings: Chronic infection with Epstein-Barr virus, hepatitis B and C viruses, Kaposi sarcoma herpes virus, human immunodeficiency virus (HIV) type 1, human papillomavirus (HPV), human T-cell lymphotropic virus type 1, Helicobacter pylori, Clonorchis sinensis, Opisthorchis viverrini, and Schistosoma haematobium are associated with nasopharyngeal carcinoma; lymphoma and leukemia, including non-Hodgkin lymphoma, Hodgkin lymphoma, and Burkitt lymphoma; hepatocellular carcinoma; Kaposi sarcoma; oropharyngeal carcinoma; cervical carcinoma and carcinoma of other anogential sites; adult T-cell leukemia/lymphoma; gastric carcinoma; cholangiocarcinoma; and urinary bladder cancer. In 2008, approximately 2 million new cancer cases (16%) worldwide were attributable to infection. If these infections could be prevented and/or treated, it is estimated that there would be about 23% fewer cancers in less developed regions of the world, and about 7% fewer cancers in more developed regions. Conclusion: Widespread application of existing public health methods for the prevention of infection, such as vaccination, safer injection practices, quality-assured screening of all donated blood and blood components, antimicrobial treatments, and safer sex practices, including minimizing one’s lifetime number of sexual partners and condom use, could have a substantial effect on the future burden of cancer worldwide. Key Words: burden, cancer, infection, vaccination Ó 2014 Icahn School of Medicine at Mount Sinai. Annals of Global Health 2014;80:384-392 INTRODUCTION viverrini, and Schistosoma (S) haematobium (Table 1).
    [Show full text]
  • Trends of Incidence and Survival Rates of Mucosa-Associated
    J Korean Med Sci. 2020 Sep 14;35(36):e294 https://doi.org/10.3346/jkms.2020.35.e294 eISSN 1598-6357·pISSN 1011-8934 Original Article Trends of Incidence and Survival Rates Oncology & Hematology of Mucosa-associated Lymphoid Tissue Lymphoma in the Korean Population: Analysis of the Korea Central Cancer Registry Database Seok-Hoo Jeong ,1 Shin Young Hyun ,2 Ja Sung Choi ,1 and Hee Man Kim 3 1Division of Gastroenterology, Department of Internal Medicine, Catholic Kwandong University International St. Mary's Hospital, Incheon, Korea Received: Jun 1, 2020 2Division of Hematology and Oncology, Yonsei University Wonju College of Medicine, Wonju, Korea Accepted: Jul 16, 2020 3Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea Address for Correspondence: Hee Man Kim, MD, PhD Department of Internal Medicine, Yonsei ABSTRACT University Wonju College of Medicine, 20 Ilsan-ro, Wonju 26426, Republic of Korea. Background: Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid E-mail: [email protected] tissue (MALT-lymphoma) is an extranodal lymphoma that occurs at various sites in the © 2020 The Korean Academy of Medical body. There is a limited understanding of the incidence and survival rates of MALT- Sciences. lymphoma. To investigate the nation-wide incidence and survival rates of MALT-lymphoma This is an Open Access article distributed in Korea during 1999–2017, the data on MALT-lymphoma were retrieved from the Korea under the terms of the Creative Commons Central Cancer Registry. Attribution Non-Commercial License (https:// creativecommons.org/licenses/by-nc/4.0/) Methods: During the time period of 1999–2017, 11,128 patients were diagnosed with MALT- which permits unrestricted non-commercial lymphoma.
    [Show full text]
  • Hepatic Dysfunction After Radiotherapy for Primary Gastric Lymphoma
    Journal of Radiation Research, 2013, 54, 92–97 doi: 10.1093/jrr/rrs062 Advance Access Publication 31 July 2012 Hepatic dysfunction after radiotherapy for primary gastric lymphoma Hidekazu TANAKA*, Shinya HAYASHI, Kazuhiro OHTAKARA and Hiroaki HOSHI Department of Radiology, Gifu University Hospital, Yanagido 1-1, Gifu 501-1194, Japan *Corresponding author. Department of Radiology, Gifu University Hospital, Yanagido 1-1, Gifu 501-1194, Japan. Tel: +81-58-230-6439; Fax: +81-58-230-6440; E-mail: [email protected] (Received 29 April 2012; revised 28 June 2012; accepted 28 June 2012) Patients with primary gastric lymphoma (PGL) are often treated with three-dimensional conformal radiotherapy (3D-CRT) in three to four fields to reduce the dose to the left kidney. However, the liver dose is higher than conventional parallel-opposed fields. This study was designed to evaluate hepatic dysfunction after 3D-CRT in patients with PGL. The data of 20 PGL patients treated with 3D-CRT were analyzed. Of the 20 patients, 3 had mucosa-associated lymphoid tissue (MALT) lymphoma and 17 had diffuse large B-cell lymphoma (DLBCL). The median dose used to treat MALT lymphoma was 30 Gy and 40 Gy for DLBCL. Pretreatment and post-treatment transaminase and alkaline phos- phatase (ALP) values were compared. Radiation-induced hepatic dysfunction (RIHD) was defined as a more than 2-fold increase in transaminase or ALP levels, exceeding the upper limit within 4 months of the completion of radiotherapy. Increased transaminase or ALP levels were observed in 19 patients (95%). RIHD was observed in 14 patients (70%). The transaminase and ALP values were significantly different between pretreatment and post-treatment.
    [Show full text]
  • Second Gastric Cancer After the Treatment of Primary Stomach
    Case Report iMedPub Journals Cancer: Open Access 2017 http://www.imedpub.com ISSN 2471-9943 Vol. 3 No. 1: 1 DOI: 10.21767/2471-9943.100031 Second Gastric Cancer After the Treatment Bahri M1,6,7, Ben Salah H1,6, of Primary Stomach Diffuse Large B-Cell Boudawara T2,6, Mzali R3,6, Lymphoma Tahri N4,6, Frikha Me5,6 and Daoud J1,6 1 Department of Radiotherapy, CHU Habib Abstract Bourguiba, Sfax, Tunisia 2 Department of Pathology, CHU Habib We report a case of gastric carcinoma occurred 11 years after treatment of gastric Bourguiba, Sfax, Tunisia lymphoma in a 38-year-old patient with a review of the literature. 3 Department of Surgery, CHU Habib Keywords: Gastric lymphoma; Second primary cancer; Stomach cancer; Helicobacter Bourguiba, Sfax, Tunisia pylori; Radiotherapy 4 Department of Gastroenterology, CHU Hedi Chaker, Sfax, Tunisia 5 Department of Oncology, CHU Habib Received: January 20, 2017; Accepted: February 01, 2017; Published: February 07, 2017 Bourguiba, Sfax, Tunisia 6 Faculty of Medicine, Sfax, Tunisia 7 Regional Hospital of Mohamed Ben Introduction Sassi, Gabes, Tunisia Adenocarcinoma and lymphoma are the two most common malignant tumors of the stomach [1,2]. The occurrence of second Corresponding author: Bahri M cancer after the treatment of gastric diffuse large B-cell lymphoma is rare [1,2]. We report a case of gastric carcinoma occurred after [email protected] the treatment of gastric lymphoma with a literature review. Case Report Department of Radiotherapy, Faculty of Medicine, CHU Habib Bourguiba, Regional A 38-year-old man was consulted at our hospital in 2002 with Hospital of Mohamed Ben Sassi, Gabes, epigastric pain, vomiting, weight loss and fatigue.
    [Show full text]
  • Morphological and Immunophenotypic Variations in Malignant Melanoma
    Histopathology 2000, 36, 387±402 REVIEW Morphological and immunophenotypic variations in malignant melanoma S S Banerjee & M Harris Department of Histopathology, Christie Hospital, Manchester, UK Banerjee S S & Harris M (2000) Histopathology 36, 387±402 Morphological and immunophenotypic variations in malignant melanoma A variety of cytomorphological features, architectural and very rarely pseudoangiosarcomatous change, gran- patterns and stromal changes may be observed in ulomatous in¯ammation or osteoclastic giant cell malignant melanomas. Hence, melanomas may mimic response may be seen in the stroma. The stromal blood carcinomas, sarcomas, benign stromal tumours, lymph- vessels may exhibit a haemangiopericytomatous pattern, omas, plasmacytomas and germ cell tumours. Melan- proliferation of glomeruloid blood vessels and perivascular omas may be composed of large pleomorphic cells, small hyalinization. Occasionally, differentiation to nonmelan- cells, spindle cells and may contain clear, signet-ring, ocytic structures (Schwannian, ®bro-/myo®broblastic, pseudolipoblastic, rhabdoid, plasmacytoid or balloon osteocartilaginous, smooth muscle, rhabdomyoblastic, cells. Various inclusions and phagocytosed material ganglionic and ganglioneuroblastic) may be observed. may be present in their cytoplasm. Nuclei may show bi- Typically melanomas are S100 protein, NKIC3, HMB-45, or multi-nucleation, lobation, inclusions, grooving and Melan-A and tyrosinase positive but some melanomas angulation. Architectural variations include fascicula- may exhibit
    [Show full text]
  • Long-Term Clinical Outcome and Predictive Factors for Relapse After
    cancers Article Long-Term Clinical Outcome and Predictive Factors for Relapse after Radiation Therapy in 145 Patients with Stage I Gastric B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue Type Heerim Nam 1 , Do Hoon Lim 2,*, Jae J. Kim 3, Jun Haeng Lee 3, Byung-Hoon Min 3 and Hyuk Lee 3 1 Department of Radiation Oncology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea; [email protected] 2 Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea 3 Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea; [email protected] (J.J.K.); [email protected] (J.H.L.); [email protected] (B.-H.M.); [email protected] (H.L.) * Correspondence: [email protected]; Tel.: +82-2-3410-2619 Simple Summary: Helicobacter pylori-associated gastric low-grade B-cell lymphoma of mucosa- associated lymphoid tissue type (MALT lymphoma) constitutes >80% of gastric MALT lymphoma. Eradication therapy has been accepted as a standard approach for initial treatment. However, in patients who present without evidence of infection or who fail to respond to eradication therapy, a solid consensus for treatment is not available. Furthermore, few studies have evaluated the predictive factors for response or relapse after radiation therapy (RT) as heterogeneous, relatively small study populations have been treated with RT, and only a small number of events have been reported after treatment. In this study, we report the long-term clinical outcome of stage I gastric MALT lymphoma treated with RT. We also identified that the tumor’s dominant location in the Citation: Nam, H.; Lim, D.H.; Kim, stomach is a predictive factor for relapse after RT.
    [Show full text]