2010 2010 Research Publications & Research of Medicine 2010 - Faculty and Health Sciencies Profiles

YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20

هيئة التحرير PRODUCTION CREDITS المحرر: Editor: األستاذ ويم المرز Prof Wim Lammers السكرتير اإلداري: Secretarial Management: السيد راجاغوباالن Mr P Rajagopalan التصميم: Graphic Design: السيدة إفانا ليزاريتوري Ms Ivanna Lizarriturri التخطيط والتنسيق: :Layout and Formatting السيدة ادريانا كازكي Ms Adriana Khazki التصوير: Photography: السيد أشوك براساد Mr Ashok Prasad الترجمة: Arabic Translation: اآلنسة العنود الجابري Ms Al-Anood Al-Jaberi

Inside research images provided by the individual researchers

الصور المدرجة بالداخل من قبل الباحثين

المنشورات السنوية لمكتب العميد المشارك Annual Publication of the Office of The Assistant Dean لشؤون البحث العلمي و الدراسات العليا for Research & Graduate Studies

طبع بواسطة وحدة المطبوعات Printed by Publication Department, جامعة االمارات العربية المتحدة UAE University Contents

Dean’s message Foreword from the Associate Dean for Research & Graduate Studies Preface UAEU Global Health Institute

Research Publications by Department 1 Immunology and Immunoregulation 114 Anatomy 3 MERGE 116 Biochemistry 8 Neurosciences 118 Community Medicine 18 Oncology 121 Family Medicine 26 Trauma 123 Internal Medicine 32 Medical Education 38 Medical Student Research 127 Medical Microbiology & Immunology 41 Obstetrics & Gynaecology 50 Research Support 133 Paediatrics 53 The Analytical Services 134 Pathology 64 The Electrophysiology Centre 136 Pharmacology 71 The Imaging Unit 137 Physiology 78 The Molecular Cellular Biology Facility 138 Psychiatry 87 The National Medical Library 139 Radiology 92 Surgery 95 Impact Factors 141

Research Priority Groups 105 Diabetes and Cardiovascular 107 Genetics and Development 110 Dean’s Message

It gives me great pleasure to provide an introduction to the 2010 edition of the Faculty of -Medicine and Health Sciences (FMHS) Research Publications.

This is a particularly important edition as it marks the twenti- eth issue of the FMHS Research Publications and is therefore a significant milestone in the ongoing scientific output of the FMHS. My congratulations go to all faculty members who have contributed to the high level of research productivity evident in this edition. Our researchers, in conjunction with graduate students, medical students, and technical staff make important contributions to clinical literature and to scientific advance- ment in the UAE and internationally. Their continued dedica- tion and productivity ensures that the FMHS maintains its record of enviable research accomplishments over the last two decades.

A highlight of 2010 was the UAEU Conference, Global Health and the UAE: Asia–Middle East Connections which discussed how the mixture of people, customs and commerce resulting from an increasingly mobile population are giving rise to new global health problems. The success and impact of this con- ference activated plans to establish a Global Health Institute whose main areas of research will be population health, both physical and mental, to include patterns and risk factors of lifestyle diseases as well as epidemic diseases. While recruit- ment efforts continue, the UAEU has appointed a member of the FMHS Community Medicine Department, Dr Iain Blair, as Interim Director of the Global Health Institute.

FMHS Research Priority Groups provide stimulus to the UAE scientific community and are greatly relevant to health issues within the country. The Groups focus on addressing the health concerns of the nation under the areas of: Genetics and Devel- opment, Trauma, Oncology, Neuroscience, Immunoregulation and Infection, Diabetes and Cardiovascular, Medical Education. We are most indebted to the following benefactors for the on- going sponsorship of our research and gratefully acknowledge their support: ɜSheikh Hamdan Award for Medical Sciences ɜTerry Fox Cancer Funds in Dubai, Abu Dhabi and Canada ɜWellcome Trust, UK - Viral genetics and vaccines development ɜMichael J Fox Foundation, USA - Parkinson’s disease ɜBritish Council in the UAE ɜALESCO - Neuroscience ɜHarvard International - Cancer ɜDubai Harvard - Genetics ɜThrasher Research Fund - Vitamin deficiency ɜSatiogen - Diabetes ɜSonisite - Trauma ɜRed Crescent - Trauma ɜAbu Dhabi Environment Agency – Environmental health ɜUniversity of North Carolina - Environmental health ɜUniversity of California – Genetics ɜChildren’s Hospital, Boston - Genetics ɜHAAD - Occupational Health ɜAbu Dhabi Food Authority - Dates & Diabetes ɜICGEB - Genetics & Cancer

The UAEU places emphasis on high quality research and we at the FMHS are pleased to be in a position to respond posi- tively to this challenge. We remain committed to this priority and strive to increase our efforts to further develop the FMHS research capabilities and output. I am impressed by the contin- ued high-quality output of our dedicated researchers, especial- ly considering the adverse conditions experienced during the global financial crisis. Congratulations to you all and thank you for your continued achievements.

Prof. Mohamed Yousif Hasan Baniyas ŌY -īŠ{ª{ŽšȯĘ-)Y mĶ Y-t -Žt)Õ-tȯã Ÿmš±{7Ę-)Y Yt-t)ð-mšVĶ Y-t -Ž

Foreword from the Assistant Dean for Research & Graduate Studies

I am proud to present to you this 20th anniversary edition of our faculty’s research profile and contributions.

As in the previous 19 years, we maintain this now 20-year old tradition that has kept our community aware of the research endeavors and contributions to the United Arab Emirates University and the academic environment in the nation and abroad. Through our numerous peer-reviewed publications, attendance and contribution to national and international scientific meetings and other scholarly activities, we maintain our premium position as the top biomedical research center in the Emirates and one of the top in the MENA region.

Such a common endeavor can only be achieved and maintained in a progressive and cooperative environment. The Office of Research and Graduate Studies aims to promote such an environment by allocating resources wisely, to nurture incoming faculty, providing resources to maintain old equipment and install new equipment, and by running a faculty store for general consumables. In this anniversary edition, we have highlighted our central research facilities such as the Analytical Services, the Electrophysiology Center, the Electron and Confocal Laser Microscopy Imaging Unit and the Molecular Cellular Biology Facility. Of course, we have also provided space to the achievements and staff involved in our National Medical Library.

We should also acknowledge the contribution and ongoing support by the United Arab Emirates University, who are very active in implementing the research, vision of His Excellency the Chancellor Sheikh Nahayan Mabarak Al Nahayan who has repeatedly stated the top priority position for research at the UAE University.

With this anniversary edition, it is my privilege to thank all my predecessors in this office who started on this ambitious project so many years ago: Professors Wim Lammers (1990-1994), Andrew Garner (1995-1997), Sehamuddin Galadari (1998-2000), and Mio Lukic (2001-2007).

Professor Sehamuddin Galadari Assistant Dean for Research & Graduate Studies (2008-2011)

Preface

This is the 20th yearly report on Research Publications and Research Profiles for the Faculty of Medicine & Health Sciences, United Arab Emirates University. This volume is part of an unbroken series of research annual reports, dating back to our very first report in 1991.

We have continued to include the Departmental Profiles and the Reports from the Research Priority Groups, together with a report on Student Medical Research. This year we have included reports from the central laboratory facilities that support our research. And, finally, we open the booklet with a few pages dedicated to the foundation of the new Global Health Institute, a joint effort of FMHS and UAEU.

At this stage, it has always been our pleasure to thank those who have been involved in one way or another with the production of the annual booklet. This time, in this special anniversary edition, it is my pleasure to thank all those who have been involved in one way or another with all 20 productions from the very first 1991 edition:

Renata Crawford, Sandra Child, Helga Fiedler, Lorainne Ritchie, Joel Lanphear, Fiona White, Maha Hashem, Valerie Gondek, Adnan Tahir, Ms Ubaldine, Ivanna Lizarriturri, Shaikha Al Mazrouei, Ashok Prasad, Rajagopalan, Ali Ladahri, Mahmoud Mahmoud, Mohammed Zagar, Pamela Roberts, Al-Anood Al- Jaberi and Adriana Khazki.

And, obviously, we must also thank all those members of Faculty and staff who have published at FMHS in the past twenty years, making FMHS by far the leading publisher in biomedical research in the nation(*).

Dr W Lammers, Editor

(*) Neves K, Lammers WJ. Growth in biomedical publications and scientific institutions in the Emirates (1998-2004); an Arabian renaissance? Health Info Libr J. 2007 24:41-49

UAEU Global Health Institute



A unique conference Global Health and the UAE: Asia–Middle East Connections was held at the United Arab Emirates University (UAEU) in January 2010. Delegates discussed the global health problems that are emerging along the route of the new silk road which links the global cities of the UAE and Middle East with Mumbai, Kuala Lumpur, Singapore, Shanghai and Hong Kong1 .

Following the conference, the foundations of a Global Health Institute have been laid. As a key hub in the global network, the UAE is ideally placed to host this new Institute and it is appropriate that it should be established at UAEU where it will start to draw together experts and scholars to research the health issues faced by the Nation and the wider Region.

It is planned that the Institute's main areas of research will be population health (in particular the patterns and risk factors of diabetes, cardiovascular disease, genetic disorders and injury), the social and family factors that influence health behaviour, migrant health, epidemic disease and air travel, refugee physical and mental health and the challenges facing local health systems. So far, work at the Institute has been focussed on seeking sponsorship, recruiting to a newly established faculty position in ethnography and exploring international links. The Institute is already funding two substantial research projects and Sir Richard Feachem, Professor of Global Health at the University of California has agreed to work with UAEU over the next three years to help to establish the Institute. Faculty and staff in FMHS and other UAEU colleges with an interest in global health who would like to contribute to the work of the Institute will be welcome to become affiliates of the Institute. A website for the Institute is under construction (http://www.fmhs.uaeu.ac.ae/ globalhealth/) and contributions will be appreciated.

For more information contact Dr Iain Blair: ([email protected]) Interim Director, Dept. of Community Medicine Faculty of Medicine & Health Sciences

ʪótV{ŠtĘÏȮótšŠ{)Ÿ šY{tȰäm{mð-mšVt)šV-ŁÀÙȰÀŽYɐĘY))m-ÙŽšÏ{tt- šY{tŽȮ ÀŽYɍī YA Ċ{ŸŠtm{7īŸmY ð-mšVʬʩʪʩȱʬʬɮʭɯȰʰĶɐʳĶ

Research Publications by Department

20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICALAnatomy RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICALBiochemistry RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICALCommunity RESEARCH Medicine AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICALFamily RESEARCH Medicine AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICALInternal RESEARCH Medicine AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICALMedical RESEARCH Education AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICALMedical RESEARCH Microbiology AT FMHS I 20& YEARSImmunology OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICALObstetrics RESEARCH & GynaecologyAT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICALPediatrics RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICALPathology RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICALPharmacology RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICALPhysiology RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS Psychiatry 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICALRadiology RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICALSurgery RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS

Department of Anatomy

Research Profile

Academic staff in the Department of Anatomy Professor & Chair: pursue research interests in a number of Prof E Adeghate Professor: directions. We show considerable strength in Prof K M Bagnall the fields of neurobiology, stem cells, cancer, Prof G R Buzzell diabetes, and structure/function relations. Prof S M Karam Prof D E Lorke Associate Professor: Dr E Mensah-Brown Ernest Adeghate’s major research interest is on the effect of pan- Dr S Shehab creas transplantation on metabolic parameters in experimental Medical Research Specialist: diabetes. He also examines the role of neuropeptides on insulin Mr R S Hameed and glucagon secretion from the pancreas, especially in diabetic Ms W Al Dhaheri condition. Recent results from his laboratory showed that spexin, Ms A Rifaat a newly discovered peptide, is expressed in pancreatic beta cell. Mr S Singh This indicates that spexin may be implicated in the regulation Mr S Tariq and control of islet function including insulin metabolism. Mr W Wanniarachi Medical Research Technician: Mr M Madathil Secretary: Ms L Ravindranathan Office Assistant: Mr TV Basheer

Immunolocalization of spexin in the pancreas of normal Wistar rat Immunofluorescence micrograph, showing spexin immunoreactive cells (red) in pancreatic islet of normal Wistar rat, Magnification: X 200.

3 Department of Anatomy

Keith M. Bagnall’s research has focused in three addition, he is involved in cooperative clini- areas. He is interested in the aetiology of ado- cal research, performing experimental studies lescent idiopathic scoliosis and is trying to find on the development, imaging and therapy of indicators of future development of this disease malignant tumors and on the side effects of as well as indicators of progress of the spinal gadolinium-based radio contrast media. curves if they develop. He is also interested in the repair of articular cartilage by the introduc- Eric Mensah-Brown continues to work on the tion of cultured chondrocytes or stem cells. A mechanisms underlying multiple low dose third interest involves identifying the attributes diabetes with particular interest in the role of necessary to be a successful clinician and the interferon gamma and IL-17 in autoimmune dia- development of tests to predict the future betogenesis. Presently, he is studying the role performance of medical students, especially on of the TLR-2 agonists, peptidoglycan and PAM3 the wards. CYS-CK4 (PAM3) via their induction of IL-17 and interferon gamma secretion on diabetogenesis. Sherif Karam’s main research focuses on some Dr. Mensah-Brown also investigates the role of fundamental aspects of stem cell biology. Stem cytokines and the protective role of microglia in cells of the gastric glands and mammary glands the rodent model of multiple sclerosis, experi- are investigated to define the modulation of mental allergic encephalomyelitis, EAE. their proliferation and differentiation during carcinogenesis. Also, the regenerative potentials Safa Shehab studies the reorganization of the of isolated gastric and dental pulp stem cells are neuronal circuitry in the dorsal horn of the spi- investigated. nal cord after peripheral nerve section. His find- ings do not support the notion that peripheral Dietrich E. Lorke’s main research activities are nerve section causes sprouting of either injured in the area of neuroembryology. He studies or adjacent uninjured primary afferents in the developmental changes in the expression of dorsal horn. He is currently investigating the neurotransmitters (GABA, catecholamines), neuronal pathways that are likely to be critical of receptors (glycine receptor, nicotinic ace- in the production of the neuropathic pain. He is tylcholine receptor, NMDA receptor, estrogen also investigating the role of the basal ganglia receptor-related receptor) and of functional in suppressing epileptic seizures. His recent parameters (functional MRI, c-fos) in different findings showed that the subthalamic nucleus brain regions of rodents and humans. Together might not have critical role in suppressing tonic with his collaborators at the Center of Molecular seizure. He is currently investigating the mecha- Neurobiology, Hamburg, he investigates altered nisms of deep brain stimulation and whether brain development in mutant mouse strains, high frequency stimulation of substantia nigra including knock-out mice, and studies the reac- can produce anticonvulsant effects using an tion to injury in the spinal cord of mutant mice. animal model of epilepsy. His second research interest is concerned with the blood-brain barrier. In collaboration with the Department of Pharmacology, FMHS, he analy- ses factors influencing the passage of oximes into the brain. Oximes are important adjunct therapeutics in the treatment of organophos- phorus poisoning. Together with researchers at the Faculty of Military Health Sciences, Hradec Kralove, Czech Republic, the efficacy of various newly developed oximes in the therapy of or- ganophosphorus poisoning is tested. Together with his colleagues at the Chinese University of Hong Kong, he characterizes neurotransmit- ter expression in the central nervous system of different vertebrates and studies apoptotic cell death as well as neurotransmitter changes during aging and in Alzheimer’s disease. In

4 Department of Anatomy

the camel (Camelus dromedarius). Mensah-Brown EPK, Shahin A, Al Articles in Peer- Anatomical Record 293(10):1776- Shamsi M, Lukic ML (2010). Early reviewed Journals 1786. influx of macrophages determines susceptibility to experimental Adeghate E, Fernandez-Cabezudo Fernandez-Cabezudo MJ, Lorke allergic encephalomyelitis in M, Hameed R, El-Hasasna H, El DE, Azimullah S, Mechkarska M, Dark Agouti (DA) rats. Journal of Wasila M, Abbas T, al-Ramadi B. Hasan MY, Petroianu GA, al- Neuroimmunology. [Epub ahead (2010). Orexin-1 receptor co-local- Ramadi BK. (2010). Cholinergic of print] PMID: 21109309. izes with pancreatic hormones in stimulation of the immune system islet cells and modulates the out- protects against lethal infection Schuster RK, Sivakumar S, Kinne J, come of streptozotocin-induced by Salmonella enterica sero- Babiker H, Traversa D, Buzzell GR diabetes mellitus. PLoS ONE 5 (1): var Typhimurium. Immunology (2010). Cutaneous and pulmonal e8587. 130:388-398. habronemosis transmitted by Musca domestica in a stable in the Adeghate E, Kalasz H, Veress G, Kalász H, Adem A, Hasan MY, United Arab Emirates. Veterinary Tekes K. (2010). Medicinal chem- Adeghate E, Ram N, Gulyás Parasitology 174 (1-2):170-174. istry of drugs used in diabetic Z, Tekes K. (2010). Medicinal cardiomyopathy. Current Medici- chemistry of antiviral/anticancer Tokuda T, Qureshi MM, Ardah MT, nal Chemistry 17 (6): 517-551. prodrugs subjected to phosphate Varghese S, Shehab SA, Kasai T, conjugation. Mini Reviews in Me- Ishigami N, Tamaoka A, Nakagawa Adeghate E, Hameed RS, Ponery dicinal Chemistry 10: 822-845. M, El-Agnaf OM. (2010). Detec- AS, Tariq S, Sheen RS, Shafiullah M, tion of elevated levels of {alpha}- Donath T. (2010). Early morpholog- Kalász H, Hasan MY, Adeghate E, synuclein oligomers in CSF from ical, physiological and biochemical Tekes K, Adem A. (2010). Chroma- patients with Parkinson disease. events in streptozotocin-induced tographic separation of antiviral/ Neurology 75:1766-1772. diabetes mellitus. Experimental anticancer nucleoside reverse and Clinical Endocrinology and transcriptase inhibitor drugs. Ana- Diabetes 118(10): 699-707. lytical and Bioanalytical Chemistry k 398: 295-312. Bagnall KM, Grivas TB, Alos N, Asher M, Aubin CE, Burwell GR, Karam SM. (2010). Mouse models Published Dangerfield PH, Edouard T, Hill D, demonstrating the role of stem Abstracts, Lou E, Moreau A, O’Brien J, Stokes cells in gastric carcinogenesis. I, Weiss HR, Raso J. (2010). The Frontiers in Biosciences 15:595- Letters and IRSSD and its contribution to sci- 603. Correspondence ence. Scoliosis 22: 4-28. Karam SM. (2010). A focus on Bastaki SMA, Amir N, Adeghate Barley R, Adesida AB, Bagnall KM, parietal cells as a renewing cell E. (2010). Effect of Turmeric on Jomha M. (2010). Immunohis- population. World Journal of Gas- serum IL-23 levels and histological tochemical characterization of troenterology 16:403-411. parameters in acetic-acid-induced reparative tissue present in human inflammatory bowel disease in osteoarthritic tissue. Virchows Lammers WJ, Karam SM. (2010). rats. Journal of Gastroenterology Archives 456 (5):561-9. Neurogastroenterology and Hepatology, 25 (Suppl 2): A76-A76. motility around the world. Neu- Barley RDC, Bagnall KM, Jomha rogastroenterology and Motility Howarth FC, Ljubisavljevic M, NM. (2010). Histological scoring of 22:946-949. Qureshi MA, Adeghate E, Shafiul- articular cartilage alone provides lah M, Jacobson M. (2010). an incomplete picture of oste- Langer RD, Usmani A, van Gorkom Heart rhythm disturbances in oarthritic disease progression. KN, Lorke DE, Petroianu G, Azimul- two experimental rat models of Histology and Histopathology 25 lah S, Nurulain SM. (2010). In alloxan-induced diabetes. Journal (3): 291-7. vitro assessment of the antibiotic of Molecular and Cellular Cardiol- efficacy of contrast media and ogy 48: S131 Bastaki SMA, Adeghate E, antibiotics and their combinations Chandranath IS, Amir N, Tariq S, at various dilutions. British Journal Lammers WJ, Al-Bloushi HM, Al- Hameed R, Adem A. (2010). Ef- of Radiology 83:394-400. Eisaei SA, Al-Dhaheri FA, Stephen fects of Streptozotocin-induced B, George RR, Dhanasekaran S, Ka- long-term diabetes on parietal cell Lorke DE, Wai MS, Liang Y, Yew DT ram SM. (2010). ICC and slow wave function and morphology in rats. (2010). TUNEL and growth factor propagation in the small intestine Molecular and Cellular Biochemis- expression in the prefrontal cortex of diabetic rats. Gasgtroenterol- try 341(1-2):43-50 of Alzheimer patients over 80 ogy, 138/5, S2067. years old. International Journal of Buzzell GR, Kinne J, Tariq S, Wern- Immunopathology and Pharma- Singh J, Howarth FC, Adeghate E, ery U. (2010). The pleural curtain of cology 23(1):13-23. D’Souza A. (2010). Morphological

5 Department of Anatomy

changes in the hearts of diabetic Fahim M, Karam SM, al-Ramadi Prof SM Karam rats. Journal of Molecular and Cel- B. (2010). Ghrelin enhances the Lectin binding and cell prolifera- lular Cardiology 48: S11–S12. regenerative potential of stem tion analysis during early events of cells. The Annual meeting of mammary gland carcinogenesis. the Federation of the American k Societies of Experimental Biology Dr E Mensah-Brown (FASEB), USA. The effects of Toll-like receptor-2 ligand, peptidoglycan on the Proceedings, Fernandez-Cabezudo M J, Az- development of autoimmune Conferences, imullah, Al-Barazie S R, Lorke D, diabetes: An analysis in multiple Shehab S, Hasan M, Petroianu G, low dose streptozotocin-induced Invited Lectures, Al-Ramadi B. (2010). Differential diabetes in wild type mice, Web Sites immunoregulatory effects of two interferon-gamma and iNOS defi- organophospahte cCompounds, cient mice. and Others diisopropyl fluorophosphates and paraoxon, on the host’s response Dr S Shehab Al Ameri MH, Al Ahbabi SS, Al to infection. The 50th Annual Neuroanatomical circuitry of neu- Dhaheri AM, Al Zaabi AH, Al meeting of the American Society ropathic pain. Mansouri LS, Mammeed R, Laleye for Cell Biology (Dec. 11-15), Phila- L, Abbas T, Adeghate E. (2010). delphia, PA, USA Dr S Shehab, Prof M Ljubisavljevic Effect of camel milk on metabolic (PI) NPY and streptozotocin- parameters in type 1 diabetes. The Karam SM. (2010). Role of induced diabetic neuropathy-pre- 7th Scientific Conference for Medi- epithelial progenitors in gastric liminary evaluation of behavioral cal Students in the GCC Countries, carcinogenesis. The International and spinal pain processing Jeddah, February 13-16. Anatomical Sciences and Cell Biol- changes (With Professor M. Ljubi- ogy Conference, Singapore savljevic). Al-Dhaheri W, Adi M, Al Kendi F, Al Kaabi M, Karam SM. (2010). Lotfy M, Singh J, Adeghate E. Alteration of carbohydrate expres- UAEU Individual Grants (2010). Protective effect of GLP-1 sion and stem cells during breast and exenatide on rat pancre- cancer development. The 2nd Prof E Adeghate atic beta cells. Annual Graduate SEHA Research Conference, Abu Effect of visfatin and adiponectin School Conference, University of Dhabi, UAE. on the metabolic parameter of Central Lancashire, Preston, UK. diabetic rats. Al-Dhaheri W, Hassouna I, Karam Mensah-Brown E, Shahin A, Lukic SM. (2010). Genes involved in Prof DE Lorke ML. (2010). Interplay of cytokines breast cancer development due to In vitro study of the efficacy of in experimentally-induced diabe- an environmental carcinogen. The adding antibiotics to nonionic tes: IL-17 VRS Interferon-gamma. 2nd Annual e-Health Conference, contrast media for intradiscal use 7th International Congress on Dubai, UAE. at discography in order to reduce Autoimmunity, Ljubljana, Slovenia bacterial growth. May 5-9. Al Kitbi M, Howarth FC, Singh J, D’Souza A, Qureshi A, Tariq S, Dr E Mensah-Brown Shehab S, Al-Nahdi A, Al-Zaabi Hameed R, Adeghate E. (2010). Ef- Antigen presentation and CNS F, Al-Mugaddam F, Al-Sultan M fects of type 1 and type 2 diabetes immune-mediated inflamma- and Ljubisavljevic M. (2010). Does on contractile proteins of the iso- tion: The role of dendritic cells in deep brain stimulation of substan- lated rat heart. The 7th Scientific experimental allergic encephalo- tia nigra suppress tonic epileptic Conference for Medical Students myelitis. seizures? 16th World Congress on in the GCC Countries, Jeddah, Basic and Clinical Pharmacology, February 13-16. UAEU Interdisciplinary Grants Copenhagen, Denmark. Bagnall KM, Bater J, Secretan C, Prof SM Karam Barley R, Jomha N. (2010). The im- Ghrelin and recovery after anti- portance of cell density during the k neoplastic and cytotoxic therapy. culture of chondrocytes for the repair of articular cartilage. IRSSD Sheikh Hamdan Award for Meeting, Montreal. RESEARCH GRANTS Medical Sciences

Bagnall KM, Bater J, Secretan C, FMHS Research Grants Prof E Adeghate Barley R, Jomha N. (2010). Baseline Effect of pancreatic beta cell values of gene expression levels Prof E Adehgate transplantation on the metabolic for cultured chondrocytes should Modulation of streptozotocin- parameters of diabetic rats. be obtained from chondrocytes in induced diabetes by orexin-1 situ. IRSSD Meeting, Montreal. receptor.

6 Department of Anatomy

Dr E Mensah-Brown National Research Foundation The mechanisms of Repetitive Roles of toll-like receptor-2 ligands Grant Transcranial Magnetic Stimula- in the pathogenesis of autoim- tion (rTMS) induced modulation mune diabetes: An analysis in Prof SM Karam of brain plasticity in health and multiple low dose streptozotocin- Greish YE, Karam SM, Murad A: disease. induced diabetes in wild type, Nanofibrous Scaffolds for Stem interferon gamma, interleukin-17 Cell Transplantation. National Emirates Foundation Grant and iNOS deficient mice. Research Foundation. Prof E Adeghate Dr S Shehab Prof SM Karam Effect of embryonic pancreatic Does high frequency stimulation Karam SM, Branicki F: Stem Cell beta cell transplantation on the of the substantia nigra suppress Genes and Gastric Carcinogen- metabolic parameters of diabetic tonic epileptic seizures? esis – contribution to a Research rats Center of Excellence on Genes and Diseases. Prof SM Karam Terry Fox Fund for Cancer Re- Karam SM, Bharwani S: Stem cells search Dr E Mensah-Brown and Helicobacter pylori in the Interplay of cytokines at the level Prof SM Karam stomachs of children”. of the target tissue determines the Role of gastric epithelial progeni- outcome of Th1/Th17 mediated tors in gastric carcinogenesis. Prof. SM Karam type 1 diabetes. Ahmed M, Karam SM, Goodis H, Prof SM Karam Chogle S. Regenerative Potential Dr S Shehab Characterization of the early of Dental Stem Cells How does deep brain stimulation stages of mammary gland carcino- work? genesis. Dr S Shehab, Profs M Ljubisavljevic k (PI), T E Adrian

2010Anatomy

Standing left to right: E Mensah-Brown, K Bagnall, RS Hameed, WAJ Wanni, S Shehab, S Karam, S Singh, S Tariq, I Khan, M Madathil, Seated left to right: TV Basheer, J Shafarin, G Buzzell, E Adeghate, W Al Dhaheri, A Rifaat, L Ravindranathan

http://www.fmhs.uaeu.ac.ae/Departments/Anatomy. Tel: 7672000 / Fax: 7672033

7 Department of Biochemistry

Research Profile

Professor & Chair: The diverse research interests of the Prof JM Conlon Department of Biochemistry include Professor: Prof OMA El-Agnaf investigations of mechanisms of Prof S Galadari transcriptional regulation, the relationship Prof H Raza of signal transduction pathways to disease, Associate Professor: Dr AH Al-Marzouqi the effects of environmental agents on the Assistant Professor: immune response and on mitochondrial Dr M J Fernandez-Cabezudo function, neurodegenerative diseases Medical Research Specialist: Ms E Ahmed particularly Parkinson’s disease, and Ms N Al-Ghafari naturally occurring bioactive peptides. Ms. A John The year 2010 saw the appointment of Dr Ms M Mechkarska Dr M Patel Ahmed Al-Marzouqi as Chair of the Graduate Mr M Qureshi Studies Committee. Prof. Sehamuddin Medical Research Technician: Galadari continued in his role as Associate Mr A Qader Secretary: Dean for Research and Graduate Studies Ms K Al-Baloushi and Prof. Omar El-Agnaf as Chair of the Neuroscience research priority group.

Neuro-modulation of the immune response (Dr. M.J. Fernandez-Cabezudo) My main research interest is to investigate the mechanism by which organophosphorus compounds (OPCs) modulate the im- mune response. It has been well described that the toxic effects of the OPCs are due to inhibition of acetylcholinesterase (AChE) in the central and peripheral nervous system, with a consequent increase in the levels of the neurotransmitter acetylcholine (ACh) which leads to cholinergic hyperstimulation. We have recently demonstrated that subchronic doses of paraoxon, the bioactive metabolite of the OPC parathion, prepared the mice for a better immune response to infection. We are currently analyzing the functional link between the nervous and immune systems.

Another area of interest, in which my laboratory is working, is the

8 Department of Biochemistry

expression of different biomarkers in cancer Molecular toxicology and cellular oxidative cells. We are directing a project in which we are stress (Prof. H. Raza) trying to correlate the expression of an intracel- My research is mainly focused on mitochon- lular protein (MCJ) in breast cancer cells with drial dysfunction in oxidative stress conditions their resistance to chemotherapy. caused by chemicals, drugs, diseases and toxicity. I am using in vivo and in vitro models Research Highlights: Our research had shown that in our studies. In addition, I am investigating the inhibition of the enzyme acetylcholineste- the mechanisms of molecular/cellular defense rase (AChE), which leads to an accumulation against toxicity and/or diseases by studying the of acetylcholine (ACh), enabled mice to mount effects of known therapeutics, phytochemicals a more effective inflammatory anti-microbial and dietary antioxidants on oxidative stress response. Immunologically, inhibition of AChE, related complications. can modulate the inflammatory response of splenic macrophages and enhance the antibody Research Highlights: In our recent studies, we response to infection in these animals. Moreo- have demonstrated that chemical-induced ver, very preliminary results suggest that AChE increased oxidative stress alters mitochondrial inhibition could also modulate macrophage bioenergetics and redox functions. Altered mi- inflammatory responses, both in infections as tochondrial functions and glutathione-depend- well as non-infections disease models. ent redox homeostasis have been implicated in toxicities and diseases including cancer, diabe-

Exposure to paraoxon improves resistance to virulent infections. Mice were treated for 1 week (A) 2 weeks (B) or 3 weeks (C) with paraoxon or saline by daily i.p. injections. At the end of the treatment period, mice were infected orally with a dose of 1.0-1.5x104 organisms of SL1344 strain of S. typhimurium and followed for survival up to day 60 post-infection. To determine the effect of AChE on enhanced survival, mice were co-administered the K-27 oxime, with or without paraoxon, (D). Results are representative of 2 independent experiments. Asterisks denote significant differences between control and paraoxon groups (*, p <0.05; **, p < 0.01). Chi square (Mantel-Cox) statistical test was used for this analysis.

9 Department of Biochemistry

In a separate study, we have investigated the mitochondrial functions and drug metabolism in camel tissues and have compared them with the tissues from other domestic and laboratory mammals. These studies have resulted in three publications in peer reviewed journals.

Protein misfolding and neurodegenerative diseases (Prof. O.M.A. El-Agnaf) Pathological studies in human neurodegenera- tive diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), dementia with Lewy bodies (DLB), the prion dementias (e.g. mad Control cow disease and its equivalent, CJD, in humans), British dementia and Huntington’s disease, have revealed abundant protein deposits (‘amyloid’) in the affected neurons. There is now substan- tial evidence from molecular genetics, trans- genic animal and the biochemical studies to suggest that the conversion of these amyloid proteins from soluble monomers to aggregated, insoluble forms in the brain is a key event in the pathogenesis of these diseases. Current research efforts in the laboratory cover

1 umol/ml-2h

the following topics: (1) Elucidating the mecha- nism of protein aggregation and deposition and their potential link to neurodegeneration and cell loss; (2) Developing novel techniques 10 umol/ml-18h for detecting amyloid aggregates, particularly in their early stages; (3) Designing peptides and small molecule inhibitors of α-synuclein and Apoptotic changes to mouse macrophages after β-amyloid aggregation and toxicity as potential treatment with acetaminophen novel therapeutics for Parkinson’s disease and Alzheimer’s disease respectively; (4) Discover- ing novel biological markers for Alzheimer’s and tes, neurodegeneration and cardiovascular dis- Parkinson’s disease; (5) Developing novel MRI- orders. Our recent studies using cancer cells and and PET-imaging compounds for Parkinson’s macrophages, when treated with higher doses disease. of NSAIDs such as aspirin and acetaminophen, have shown that increased oxidative stress and Research Highlights: Recently, we investigated mitochondrial dysfunction are the main causes the levels of α-synuclein oligomers in CSF from of cellular toxicity and cell death (apoptosis/ patients with PD and age-matched controls necrosis). We have identified molecular and using an enzyme-linked immunosorbent assay metabolic targets of cytotoxicity in cancer and (ELISA) that specifically detects α-syn oligomers. non-cancer cell lines. We also measured the total-α-synuclein levels

10 Department of Biochemistry

CSF α-synuclein levels in patients with Parkinson’s and healthy controls. Individual values of the level of total α-synuclein (A), α-synuclein oligomers (B; RLU = relative luminescence units) and the ratio of α-synuclein oligomers to total α-synuclein (C; oligomer/total ratio, %) in CSF from PD patients (solid circles) and controls (open circles). Each bar represents the mean value. Dashed lines in (B) and (C) indicate respective cutoff values that yield the most reliable sensitivity and specificity by receiver operating characteristic curves (B; 9,950 RLU/sec for the levels of CSF α-synuclein oligomers, C; 6.165% for the ratio of α-synuclein oligomers to total α-synuclein in CSF)

in CSF. The levels of α-synuclein oligomers, and chromatin, which consists of DNA, histones, and oligomers/total-α-synuclein ratio in CSF were non-histone proteins needs to be opened up or significantly higher in the PD group (p < 0.0001, altered. This is accomplished as a result of DNA Mann-Whitney U test) compared with those and histone modifications or by DNA binding in the control group. The area under the ROC proteins. Many studies in the past few years curve (AUC) indicated sensitivity of 75.0% and have described conserved protein complexes specificity of 87.5% with an AUC of 0.859 for whose function is to modulate the access of increased CSF α-synuclein oligomers in clinically transcription factors to regulatory regions of diagnosed PD cases. However, when the CSF genes relieving chromatin-mediated repression. oligomers/total-α-synuclein ratio was analyzed, The action of these complexes that are able to it provided even greater sensitivity of 89.3%, overcome the repressive effects of chromatin is and a specificity of 90.6% with an AUC of 0.948. an important step in the regulation of eukaryo- Our results demonstrate that the CSF levels of tic gene expression. α-synuclein oligomers and oligomers/total-α- synuclein ratio can be useful biomarkers for Specifically, the overall goals of my research diagnosis and early detection of PD. are to understand how certain proteins can regulate gene expression by modifying the Mechanisms of transcriptional regulation by structure of chromatin or interacting with its chromatin-modifying complexes components. We are interested in how different (Dr. A.H. Al-Marzouqi) types of chromatin modifying proteins work The research in my laboratory is focused on in turning genes on or off. This is an important understanding the mechanisms of action of the question to be addressed since gene regulation protein complexes that regulate gene expres- can determine the amount of protein produc- sion by modifying the structure of chromatin. tion required for important functions of all cells. In eukaryotes, the compaction of DNA into the This is also important since many subunits of nucleus inhibits the access of factors to DNA these chromatin-modifying proteins in humans which leads to the repression of many impor- have been implicated in the initiation of various tant cellular processes required for maintenance diseases. It is likely that errors in the function of and growth of the cell. To access the DNA and these protein complexes can result in altera- the genes, the nucleoprotein structure, called tions in the life cycle of the cell that may lead

11 Department of Biochemistry

The Fun30 binds DNA and chromatin. A, Fun30 binds to nucleosome arrays efficiently. Immobilized G5E4 (either DNA or reconstituted into nucleosomal arrays), generated as described under “Experimental Procedures,” was incubated with an equal amount of Fun30 (lanes 7–10) or the SWI/SNF complex (lanes 2–5, as control) based on anti-TAP Western blotting normalization. The amount of bound protein (SWI/SNF complex or Fun30) was determined by separating the supernatants (S) from the beads (B), washing the beads, and running them on a 12% SDS gel followed by Western blot analysis using the anti-TAP antibody for detection of the proteins. The background binding of SWI/SNF or Fun30 to the magnetic Dynabeads alone are shown in lanes 1 and 6, respectively. B, nucleosomes were assembled on the fragment 0W47 in which the 601 nucleosome positioning sequence directs assembly of a nucleosome such that it is flanked by 47 bp of linker DNA on one side. Incubation of 30 nM 0W47 nucleosomes with increasing concentrations of His6 Fun30 (28 nM to 1 μM, lanes 2–11) resulted in a gel-shifted species (Nuc/Fun30). C, binding curves indicating the fraction of the Fun30-bound template following incubation with the indicated concentrations of Fun30. Quantification was based on the material remaining unbound in gel shifts such as that shown in B. , corresponds to 0W0 DNA; , corresponds to 0W47 nucleosomes; and , corresponds to 0W0 nucleosomes.

to the development of cancer. Thus, we are also Signal transduction pathways and disease interested in studying how chromatin misregu- (Prof. S. Galadari) lation contributes to cancer development and Biologically active sphingolipids have key could be helpful in finding potential cures for it roles in the regulation of several fundamental in the future. biological processes that are integral to cancer pathogenesis. Recent significant progress in Research highlights: The three areas of research understanding biologically active sphingolipid focus in my laboratory during 2010 were: synthesis, specifically within ceramide, sphin- t
1IZTJDBM
BOE
GVODUJPOBM
JOUFSBDUJPOT
CFUXFFO
gosine and sphingosine-1-phosphate (S1P)- the various chromatin-modifying complexes. mediated pathways, has identified crucial roles t
*EFOUJöDBUJPO
BOE
DIBSBDUFSJ[BUJPO
PG
OPWFM
for these molecules both in cancer development ATP-dependent chromatin remodeling and progression. Ceramide and sphingosine — a complexes. central molecule in sphingolipid metabolism — t
*OWFTUJHBUJOH
UIF
JO
WJWP
GVODUJPOT
PG
in effect functions as a tumour-suppressor lipids, chromatin remodelers and their roles in gene inducing antiproliferative, senescence, apoptotic silencing and autophagic responses in various cancer cells. Conversely, S1P induces responses that, on aggregate, render S1P a tumour-promoting lipid. These discoveries are paving the way for 12 Department of Biochemistry

the advancement of anticancer therapies. Ceramidases hydrolyse ceramide into sphingo- sine and fatty acid. After its generation sphin- gosine is phosphorylated to form sphingosine- 1-phosphate through the action of sphingosine A B kinase. Because the phosphorylation of sphin- gosine is the only pathway for the formation of sphingosine-1-phosphate, cellular sphingosine- 1-phosphate is highly dependent on the avail- ability of sphingosine generated by ceramidases, suggesting that ceramidases are critical in regulating not only the hydrolysis of ceramide but also the generation of both sphingosine and sphingosine-1-phosphate in cells. Therefore, the action of ceramidase leads to an alteration in cel- C lular ceramide, sphingosine, and sphingosine-1- phosphate, thereby controlling cellular respons- es mediated by these bioactive lipids. D Ceramide mediate the regulation of growth arrest, senescence, and/or apoptosis. Some of these biological functions might be controlled through novel SL-protein interactions. Most frequently, these direct targets of ceramide constitute protein phosphatases and kinases that regulate important signaling pathways in cancer, such as Akt, protein kinase C (PKC), MAP kinases, or phospholipase D. The regulation of SPH induces the DNA damage and apoptosis in Jurkat protein phosphatase-1 and -2 (PP1 and PP2A)- and Molt-4 cells. (A) Jurkat cells incubated with indicated concentration of family enzymes, also referred to as ceramide sphingosine for 6h and comet assay were performed. (B) activated protein phosphatases (CAPPs) Treatment of Jurkat cells with SPH leads to increased Annexin Our lab focuses on the following research areas V and PI staining in a dose dependent fashion. (C) Molt-4 cells incubated with indicated concentration of sphingosine for 6h 1. Purification and biochemical characterization and MTT assay were performed. (D) Treatment of Jurkat cells sphingolipid metabolizing enzymes such as with 8μM SPH for indicated time. Equal amounts of lysates neutral ceramidase isoformes from different (30 μg) were subjected to electrophoresis and analyzed by western blot for PARP. The 85 kDa proteolytic cleavage of PARP species. is indicated by the arrow. 2. Role of protein phosphatase-1 in sphingosine and ceramide induced apoptosis in human leukemic cells

Schematic representation of signaling targets of ceramide and role of spice derived phytochemicals in tumor suppression

13 Department of Biochemistry

Release of skin secretions from the Marsabit clawed from Xenopus borealis following an intradermal injection of norepinephrine

3. Investigating ceramide mediated signal ously identified, frogs belonging to the family transduction in phytochemical induced Pipidae have not been extensively studied as apoptosis in human cancer cells. a source of potential anti-infective agents. My laboratory has begun a systematic investigation Peptides with therapeutic potential from of the structural and biological properties of the frog skin (Prof. J.M. Conlon) antimicrobial peptides present in skin secretions The skins of certain species of frogs represent of frogs from the genera Xenopus and Silurana. an important source of biological active pep- In 2010, multiple biologically active peptides tides that have the potential for development were isolated from Xenopus amieti, X. andrei, X. in therapeutically valuable pharmaceutical borealis, X. clivii, X. mülleri, and Silurana parat- agents. These include bactericidal and fungi- ropicalis and their abilities to inhibit the growth cidal peptides as anti-infectives, peptides with of a range clinically important bacteria were potent cytotoxic activity against tumor cells as determined. A number of peptides with thera- anti-cancer agents, and peptides with in vitro peutic potential have been identified. and in vivo insulin-releasing activities as therapy for patients with Type 2 diabetes:

Research highlights: The anuran family Pipidae is composed of 32 species in 5 genera (Hymenochirus, Pipa, Pseudhymenochirus, Silurana, and Xenopus). All are found in Africa except for members of Pipa which are found in South America. The genus Xenopus (commonly known as African clawed frogs) currently contains 18 species, although several additional, as yet unnamed, species have been reported, and the genus Silurana contains at least four species. Despite the fact that X. lae- vis was the first amphibian species in which cu- taneous antimicrobial peptides were unambigu-

14 Department of Biochemistry

European Journal of Pharmacol- antimicrobial peptides indicate a Articles in Peer- ogy 634;10-15. close, but not conspecific, phylo- reviewed Journals genetic relationship between the Awad S., Ryan D., Prochasson P., leopard frogs Lithobates onca and Abdel-Wahab YHA, Patterson Owen-Hughes T. and Hassan A. H. Lithobates yavapaiensis (Ranidae). S, Flatt PR, Conlon JM. (2010). (2010). The Snf2 homolog Fun30 Comparative Biochemistry and Brevinin-2-related peptide and its acts as a homodimeric ATP- Physiology C (Toxicology and [D4K] analog stimulate insulin re- dependent chromatin-remodeling Pharmacology) 151: 313-317. lease in vitro and improve glucose enzyme. Journal of Biological tolerance in mice fed a high fat Chemistry 285; 9477-9484. Fernandez-Cabezudo MJ, Lorke diet. Hormone Metabolic Research DE, Azimullah S, Mechkarska M, 42; 652-656. Conlon JM. (2010). The contribu- Hasan MY, Petroianu GA, al- tion of skin antimicrobial peptides Ramadi BK. (2010). Cholinergic Adeghate E, Fernandez-Cabezudo to the system of innate immunity stimulation of the immune system M, Hameed R, El-Hasasna H, El in anurans. Cell Tissue Research protects against lethal infection Wasila M, Abbas T, al-Ramadi B. 343; 201-212. by Salmonella enterica serovar (2010). Orexin-1 receptor co-local- Typhimurium. Immunology 130; izes with pancreatic hormones in Conlon JM. (2010). Granin-derived 388-398. islet cells and modulates the out- peptides as diagnostic and come of streptozotocin-induced prognostic markers for endocrine Hasunuma I, Iwamuro S, Koba- diabetes mellitus. PLoS ONE 5: tumors. Regulatory Peptides 165; yashi T, Shirama K, Conlon JM, e8587. 5-11. Kikuyama S.(2010). Expression of genes encoding antimicrobial Al-Belooshi T, John A, Al-Otaiba A, Conlon JM, Leprince J. (2010). peptides in the Harderian gland of Raza H. (2010). Acetaminophen- Identification and analysis of bio- the bullfrog Lithobates catesbe- induced mitochondrial oxidative active peptides in amphibian skin ianus. Comparative Biochemistry stress in murine J774.2 monocyte secretions. Methods Molecular and Physiology C (Toxicology and macrophages. American Journal of Biology 615; 145-157. Pharmacology). 152; 301-305. Biomedical Sciences. 2; 142 - 154. Conlon JM, Sonnevend A. (2010). Kizhakkayil J, Thayyullathil F, Al-Belooshi T, John A, Tariq S, Antimicrobial peptides in frog skin Chathoth S, Hago A, Patel M, Al-Otaiba A, Raza H. (2010). secretions. Methods Molecular Galadari S. (2010). Modulation of Increased mitochondrial stress Biology 618; 3-14. curcumin-induced Akt phospho- and modulation of mitochondrial rylation and apoptosis by PI3K respiratory enzyme activities in Conlon JM, Ahmed E, Pal T, Son- inhibitor in MCF-7 cells. Bio- acetaminophen-induced toxic- nevend A. (2010). Potent and rapid chemical and Biophysical Research ity in mouse macrophage cells. bactericidal action of alyteserin- Communications 394; 476-481 Food and Chemical Toxicology. 48; 1c and its[E4K] analog against 2624-2632. multidrug-resistant strains of Aci- Matharu B, El-Agnaf O, Razvi A, netobacter baumannii. Peptides Austen BM. (2010) Development Al-Ghaferi N, Kolodziejek J, Now- 31; 1806-1810. of retro-inverso peptides as anti- otny N, Coquet L, Jouenne T, Lep- aggregation drugs for β-amyloid rince J, Vaudry H, King JD, Conlon Conlon JM, Al-Ghaferi N, Ahmed in Alzheimer’s disease. Peptides JM. (2010). Antimicrobial peptides E, Meetani MA, Leprince J, Nielsen 31; 1866-1872. from the skin secretions of the PF. (2010). Orthologs of magainin, South-East Asian frog Hylarana PGLa, procaerulein-derived, and Mechkarska M, Ahmed E, Coquet erythraea (Ranidae). Peptides 31; proxenopsin-derived peptides L, Leprince J, Jouenne T, Vaudry 548-554. from skin secretions of the H, King JD, Conlon JM. (2010). octoploid frog Xenopus amieti Antimicrobial peptides with Al-Otaiba A, John A, Al-Belooshi T, (Pipidae). Peptides 31; 989-994. therapeutic potential from skin Raza H. (2010). Redox homeostasis secretions of the Marsabit clawed and respiratory metabolism in Conlon JM, Coquet L, Jouenne T, frog Xenopus borealis (Pipidae). camels (Camelus dromedarius): Leprince J, Vaudry H, Iwamuro S. Comparative Biochemistry and Comparisons with domestic goats (2010). Evidence from the primary Physiology C (Toxicology and and laboratory rats and mice. Jour- structures of dermal antimicrobial Pharmacology) 152; 467-472. nal of Comparative Physiology B, peptides that Rana tagoi okiensis 180; 1121–1132. and Rana tagoi tagoi (Ranidae) Meetani MA, Zahid OK, Conlon are not conspecific subspecies. JM. (2010). Investigation of the Alptekin A, Galadari S, Shuba Y, Toxicon 55; 430-435. pyrolysis products of methionine- Petroianu G, Oz M. (2010). The enkephalin-Arg-Gly-Leu using liq- effects of anandamide transport Conlon JM, Coquet L, Leprince uid chromatography-tandem mass inhibitor AM404 on voltage- J, Jouenne T, Vaudry H, King JD. spectrometry. Journal of Mass dependent calcium channels. (2010). Primary structures of skin Spectrometry 45; 1320-1331.

15 Department of Biochemistry

Mollenhauer B, El-Agnaf OM, New York Academy of Sciences organophospahte compounds, Marcus K, Trenkwalder C, Schloss- 1200; 53-66. diisopropyl fluorophosphates and macher MG.(2010) Quantification Paraoxon, on the host’s response of α-synuclein in cerebrospinal Yang KH, Galadari S, Isaev D, to infection. The 50th Annual fluid as a biomarker candidate: Petroianu G, Shippenberg TS, Oz meeting of the American Society review of the literature and M. (2010). The nonpsychoactive for Cell Biology, Philadelphia, PA, considerations for future studies. cannabinoid cannabidiol inhibits USA. Biomarkers in Medicine 4; 683- 5-hydroxytryptamine3A receptor- 699. mediated currents in Xenopus Hassan A H. (2010). The molecular laevis oocytes. Journal of Pharma- mechanisms of chromatin re- Ohnuma A, Conlon JM, Iwamuro cology and Experimental Thera- modeling complexes. The Second S. (2010). Differential expression of peutics 333; 547-554. Genetic and Biotechnology Con- genes encoding preprobrevinin-2, ference, Sharjah, UAE. prepropalustrin-2, and prepro- Yang KH, Isaev D, Morales M, ranatuerin-2 in developing larvae Petroianu G, Galadari S, Oz Hassan A H. (2010). The molecular and adult tissues of the mountain M. (2010). The effect of Δ9- mechanisms of gene regula- brown frog Rana ornativentris. tetrahydrocannabinol on 5-HT3 tion through epigenetics. Dubai Comparative Biochemistry Physi- receptors depends on the current Harvard Foundation for Medical ology C (Toxicology and Pharma- density. Neuroscience. 171; 40-49. Research, Dubai, UAE. cology) 151;122-30. Hassan AH, Awad S., Prochasson P, Oz M, Jaligam V, Galadari S, Owen-Hughes T. (2010). The Snf2- Petroianu G, Shuba YM, Shippen- k homolog Fun30 is an ATP-depend- berg TS. (2010) The endogenous ent chromatin-remodeler with a cannabinoid, anandamide, inhibits role in DNA replication. Chromatin dopamine transporter function by Proceedings, Structure and Function, Bryant a receptor-independent mecha- Conferences, University, Smithfield, RI, USA. nism. Journal of Neurochemistry 112;1454-1464. Invited Lectures, Raza H, John A. (2010). Strepto- zotocin-induced cytotoxicity and Subasinghage AP, Conlon JM, Web Sites and mitochondrial dysfunction in hu- Hewage CM. (2010). Development Others man hepatoma HepG2 cells. 101th of potent anti-infective agents Annual Meeting of American from Silurana tropicalis: Conforma- Al-Ramadi BK, Azimullah S, El- Association for Cancer Research, tional analysis of the amphipathic, Ojali S, Issac JM, Al-Ketbi MI, Washington, DC, USA. alpha-helical antimicrobial pep- Fernandez-Cabezudo MJ. (2010). tide XT-7 and its non-haemolytic Role of MyD88 protein in host- analogue [G4K]XT-7. Biochimica pathogen interactions. The 50th Biophysica Acta (Proteins and Annual meeting of the American k Proteomics) 1804; 1020-1028. Society for Cell Biology, Philadel- phia, PA, USA. Tazato S, Conlon JM, Iwamuro S. RESEARCH GRANTS (2010). Cloning and expression of Al-Shehhi FF, Naqi MA, Mechkar- genes enocoding antimicrobial ska M, al-Ramadi BK, Fernandez- FMHS Research Grants peptides and bradykinin from the Cabezudo MJ. (2010). Role of skin and brain of Oki Tago’s brown inflammasome in macrophage Prof JM Conlon. (PI) frog, Rana tagoi okiensis. Peptides activation. The 7th Scientific Structure-activity studies of the 31; 1480-1487. Conference for Medical Students alyteserin-1 family of antimicrobial in the GCC countries, Jedda, Saudi peptides Tokuda T, Qureshi MM, Ardah MT, Arabia. Varghese S, Shehab SA, Kasai T, Dr MJ Fernandez-Cabezudo (PI) Ishigami N, Tamaoka A, Nakagawa Conlon JM. (2010). Transforma- Influence of the cholinergic anti- M, El-Agnaf OM. (2010) Detection tion of antimicrobial peptides inflammatory pathway on the of elevated levels of α-synuclein from frog skin into therapeutically development of multiple low dose oligomers in CSF from patients valuable anti-infective agents. streptozotocin-induced diabetes. with Parkinson disease. Neurology 240th American Chemical Society 75; 1766-1772. National Meeting, Boston, USA. Prof H Raza. (PI) Effect of acetaminophen on mito- Vaudry H, Do Rego JC, Le Mevel JC, Fernandez-Cabezudo MJ, Az- chondrial cytochrome P450 2E1, Chatenet D, Tostivint H, Fournier imullah S, Al-Barazie R, Lorke D, aconitase and respiratory enzyme A, Tonon MC, Pelletier G, Conlon Shehab S, Hasan M, Petroianu G, complexes in macrophages and JM, Leprince J. (2010). Urotensin II, al-Ramadi B. (2010). Differential hepatoma HepG2 cells. from fish to human. Annals of the immunoregulatory effects of two

16 Department of Biochemistry

Scientific Research Council UAE nal transduction and apoptosis as Michael J. Fox Foundation for University possible target for chemotherapy Parkinson’s Research, USA (continuation). Grants Dr MJ Fernandez-Cabezudo (PI) Cholinergic stimulation of the im- Emirates Foundation Grant Prof OMA El-Agnaf. (PI) mune system: cellular and biochemi- A strategy to develop a radiotracer cal basis of action. Dr AH Al-Marzouqi. (PI) targeting alpha-synuclein (con- The Cooperation and/or Competi- tinuation). UAE University Interdisciplinary tion between the ATP-dependant Grants Chromatin-Remodeling Protein Prof OMA El-Agnaf. (PI) SWI/SNF and the Histone Acetyl- Development of Lewy bodies MRI Prof OMA El-Agnaf. (PI) transferase SAGA in Binding to imaging agents for the early diag- Testing novel inhibitors of alpha-sy- Nucleosomes nosis of Parkinson’s disease and nuclein oligomerization and toxicity related disorders (continuation). as a novel treatment for Parkinson’s Prof S Galadari. (PI) and related disorders (continuation). Purification and characterization of a novel more hydrophobic Dubai Harvard Foundation for Terry Fox Fund for Cancer Re- isoform of N-acylsphoingosine Medical Research, Dubai, UAE search amidohydrolase Dr AH Al-Marzouqi. (PI) Dr AH Al-Marzouqi. (PI) Biochemical characterization and Investigating the mechanisms of Others functional analysis of chroma- action of the Snf2-homolog pro- tin- remodeling proteins in gene tein Fun30 (continuation). International Center for Genetic activation and silencing (continu- Engineering and Biotechnology ation). Dr MJ Fernandez-Cabezudo (PI) (ICGEB) Novel resistance biomarkers in hu- man breast cancer (continuation). Dr AH Al-Marzouqi. (PI) k Studying chromatin-modifying Prof S Galadari. (PI) proteins in transcription regula- Characterization of curcumin sig- tion (continuation).

2010Biochemistry

Standing left to right: H Raza, JM Conlon, A Qader, S Galadari, OMA El-Agnaf, Seated left to right: AH Al-Marzouqi, M Patel, A John, M Fernandez-Cabezudo, M Mechkarska, M Qureshi

http://www.fmhs.uaeu.ac.ae/Departments/Biochemstry Tel: 7672000 / Fax: 7672033

17 Department of Community Medicine

Research Profile

Professor & Chair 2010 was an eventful year for the department Prof. TC Aw of Community Medicine, especially in regards Professor Prof N Nagelkerke to research activities. Associate Professor The year started with our joint organization Dr F Al-Maskari of a major international conference on Dr R Bernsen* Dr I Blair global health. Participants from prestigious Dr M Grivna international universities and organizations Dr S Shah (including Yale, Harvard, UCLA, Simon Fraser Dr M Sheek-Hussein** Assistant Professor University, The University of Hong Kong, Dr J Schneider National University of Singapore, and Monash) Dr A Wheatley*** presented papers which were then published Medical Research Specialist Ms R Kurdi in a special supplement of the Asia-Pacific Academic Assistant Journal of Public Health. Professor Aw and Dr. Dr M El Sadig Blair worked with Professor Marcia Inhorn and Medical Secretary Ms A Kaljee Dr. Michael Dalby in organizing the event and Office Assistant editing the papers for publication. Mr M Jamal

* Departed on 31 January 2010 The conference was followed by the announcement and award ** Joined on 2 May 2010 of two research grants and the launch of a UAE Global health in- *** Departed on 31 August 2010 stitute. Syed Shah from our department was awarded one of the grants. Iain Blair was designated interim director of the Institute, and recruitment for staff has already started with expertise in ethnography and clinical epidemiology being two initial priority areas for development. We are fortunate in having Sir Richard Feachem from the University of California (and former dean of the London School of Hygiene and Tropical Medicine) on the advisory board of the institute.

Our international links also strengthened with the designa- tion of the UAE University by the Royal College of Physicians (RCP), Ireland (Faculty of occupational medicine) as an overseas examination centre for occupational medicine. Dr. Martin Hogan and Dr. Paul Guerat from the RCP (Ireland) were external exam- iners for the first exam in occupational medicine in May 2010.

18 Department of Community Medicine

Conferment Ceremony of the Faculty of Occupational Medicine (Ireland) in Al Ain, May 2010

Compilation of a portfolio comprising research was one of the most successful UAE University and field experience is part of the requirements CME events of the year. for eligibility to take the exam. Dr. Ken Addley, former Dean of the Irish Faculty of Occupational We had a steady stream of distinguished visitors Medicine, was our visiting professor in 2010. He to the department throughout the year. They collaborated with our departmental staff on a included Professor Harri Vainio, Director-General research paper for publication. of the Finnish Institute of Occupational Health, Professor Elisabete Weiderpass from the Uni- An MOU (Memorandum of understanding) versity of Tromso, Norway, and Dr. Peter Verow signed with the University of Malaya led to Dr. NHS consultant from Birmingham, UK. Several Blair and Professor Aw being invited as exter- visitors delivered research presentations to the nal examiners for their Masters and doctoral faculty. The visits also provided an opportunity research candidates. Professor Nagelkerke for discussions on research and possible col- also taught a course on advanced statistics at laboration with our staff. the University of Malaya. Following award of a research grant from the University of Leeds, UK, Community Medicine staff members continue we have started work with colleagues from the to bid for research funding from local, national, University of Malaya (Professor Awang Bulgiba) and international sources. For 2010, we suc- and the University of Leeds, UK (Dr. Jennifer Lim) ceeded in attracting research funding from the on a global health project on breast cancer. National Rehabilitation Centre (NRC), Health Authority of Abu Dhabi (HAAD), and the Emir- Two new postgraduate programmes were ates Foundation. We aim to maintain this track launched by the department of Community record and further strengthen our foundations Medicine in 2010. We accepted our first PhD for research on public health issues relevant to (Public health) candidate and several MPH the United Arab Emirates. (Masters in Public health) students. There are already enquiries for our next intake in 2011. RESEARCH INTERESTS OF FACULTY AND We envisage the research projects from our STAFF doctoral and masters students to lead to several peer-reviewed publications. Dr Fatma Al-Maskari: Public health physi- cian and epidemiologist with interest in non- Fatma Al-Maskari was awarded a research communicable chronic diseases epidemiol- grant to investigate the metabolic syndrome ogy and prevention, lifestyle and health and amongst local youths. She also continued evidence-based medicine. Dr. Al-Maskari is one with her research interest in diabetes – a major of the investigators collaborating with the Gill- public health problem in the UAE. John Schnei- ings School of Public Health at the University der completed his research on heat stress, and of North Carolina, Chapel Hill (UNC) and the the sponsoring agency (The Health Authority Environment Agency of UAE in developing a of Abu Dhabi) used the research findings to National Strategy for Environment & Health in produce guidelines for workers. Michal Grivna the UAE. organized a research seminar on the epidemiol- ogy of childhood injuries, and this attracted an Prof Tar-Ching Aw: US-Board certified in oc- audience of around 250 health professionals. It cupational medicine. He has a special inter-

19 Department of Community Medicine

Presenters, participants and guests at the UAEU Global Health Conference 2010

est in occupational toxicology, occupational related and playground injuries and more risks to health-care workers, and training and recently school traffic safety, trauma registration education. Professor Aw is a member of the and HIV/AIDS prevention in the UAE. He is a International Advisory board for the journal - founding member of the European Child Safety Occupational Medicine (Oxford Journals), and Alliance and the Centre for Childhood Injury was appointed last year to a new international Epidemiology and Prevention in the Czech journal for occupational health (Safety and Republic. Dr. Grivna is a leading figure in the Health at Work). He continues as a member of promotion and implementation of “WHO - Safe the UK Health and Safety Executive’s working Community Programs”. group on action to control chemicals (WATCH). Prof Nico Nagelkerke: Senior Biostatistician Dr Roos Bernsen: Epidemiologist and Biostat- with a special interest in statistical methodol- istician with special interest in allergy and asth- ogy and infectious disease modeling. Prof. ma. She provided consultations to the Research Nagelkerke has provided input in biostatistics to Community Medicine guest Department of the Erasmus Medical Center several projects which resulted in peer reviewed speakers at FMHS of the University of Rotterdam in the Nether- publications during 2010. Research Seminars lands for many years before joining FMHS, and conducted studies in the Netherlands on risk Dr John Schneider: Occupational health physi- factors for childhood asthma and allergy. She is cian. His main research interests are occupation- organizing related studies in the UAE. al rehabilitation, organization and planning of occupational health services in rural and remote Dr Iain Blair: Public health consultant with a work sites, work in hot environments, and im- background in UK health protection. He has pairment assessment at the workplace. published articles on the surveillance and con- trol of infectious diseases and has co-authored Dr Syed Shah: Chronic Disease Epidemiolo- a textbook on health protection and several gist with research interests in epidemiology of book chapters. His current research projects cardiovascular disease, work-related injuries and include qualitative studies on the effect of mental health. chronic illness on Emirati families and the social and environmental determinants of obesogenic Dr Mohamud Sheek-Hussein: Public health lifestyles. physician and epidemiologist with an interest in infectious diseases and public health services. Dr Mohamed El-Sadig: Epidemiologist and Dr. Sheek-Hussein is previously from the Preven- health economist, with special interest in traffic tive Medicine Department of the UAE Ministry safety and non-communicable diseases. He is of Health and lately of the Health Authority of currently a Research Director of the UAE Indoor Abu Dhabi (HAAD). Air, Health & Nutrition Study that is being undertaken jointly by our department and the Dr Andrew Wheatley: Occupational hygienist University of North Carolina. with a broad-based background in consultancy, teaching and research. Research interests Dr Michal Grivna: Public health specialist include exposure and risk characterization for physician with a special interest in child injury combustion processes, metal industries and control, school and community safety, bicycle- organic dusts.

20 Department of Community Medicine

Alsowaidi S, Abdulle A, Bernsen R. in consanguineous marriages: Articles in Peer- (2010). Prevalence and risk factors effects of altruism and ecologi- reviewed Journals of asthma among adolescents cal factors. Ann Hum Biol. 2010 and their parents in Al-Ain (United Nov;37(6):738-53. Agarwal M, Dhatt GS, Shah SM. Arab Emirates). Respiration. (2010). Simplifying the Interna- 2010;79(2):105-11. Denic S, Nagelkerke N, Agar- tional Association of Diabetes and wal MM. (2010). On Some Novel Pregnancy diagnostic alogorithm Alsowaidi S, Abdulle A, Shehab Aspects of Consanguineous Mar- using fasting plasma glucose. Dia- A, Zuberbier T, Bernsen R. (2010). riages: Response to A.H. Bittles. betes Care 2010;33:2018-2020. Allergic rhinitis: prevalence and Public Health Genomics. 2010 possible risk factors in a Gulf Dec 10. Agarwal M, Dhatt GS, Shah SM. Arab population. Allergy. 2010 (2010). Gestational Diabetes Feb;65(2):208-12. Inhorn M, Aw TC, Blair I: editors. Mellitus: simplifying the Interna- (2010) Global Health and the tional Association of Diabetes and Aw TC. (2010). Global public United Arab Emirates: Asia-Middle Pregnancy diagnostic algorithm health and the United Arab Emir- East Connections. Supplementary using fasting plasma glucose: ates. Asia-Pacific Journal of Public special issue of the Asia-Pacific Comment on Agarwal, Dhatt, and Health. Supp to 22(3):19S-24S. Journal of Public Health. Asia Pac J Shah. Diabetes Care November 1, Public Health 2010; 22: 5S-261S. 2010 33:e145. Baynouna LM, Shamsan AI, Ali TA, Al Mukini LA, Al Kuwiti MH, Al Kaul R, MacDonald KS, Nagelkerke Al-Hammadi S, Al-Maskari F, Ameri TA, Nagelkerke NJ, Abusa- NJ, Kimani J, Fowke K, Ball TB, Bernsen R. (2010). Prevalence of mak AM, Ahmed NM, Al Deen SM, Luo M, Kariri A, Jaoko W, Moses food allergy among children in Jaber TM, Elkhalid AM, Revel AD, S, Rowland-Jones S, Plummer Al-Ain city, United Arab Emir- Al Husaini AI, Nour FA, Ahmad HO, FA. (2010). HIV viral set point and ates. Int Arch Allergy Immunol. Nazirudeen MK, Al Dhahiri R, Al host immune control in individu- 2010;151(4):336-42. Epub 2009 Abdeen YO, Omar AO. (2010). A als with HIV-specific CD8+ T-cell Oct 22. successful chronic care program responses prior to HIV acquisition. in Al Ain-United Arab Emirates. AIDS. 2010 Jun 19;24(10):1449-54. Ali HI, Baynouna LM, Bernsen RM. BMC Health Serv Res. 2010 Feb (2010). Barriers and facilitators of 22;10:47. Lee KK, Shah SM, Moser MA. (2010) weight management: perspec- Risk factors predictive of severe tives of Arab women at risk for Bernsen R, Aardoom H, diverticular hemorrhage. Interna- type 2 diabetes. Health Soc Care Nagelkerke N, Van der Wouden tional J Surgery 2010;9:83-85 Community. 2010 Mar;18(2):219- J. (2010). Refusal to Participate in 28. Epub 2010 Jan 4. Blood Testing in a Study of Child- Lestari ES, Duerink DO, Hadi U, hood Immunizations and Atopic Severin JA, Nagelkerke NJ, Kunta- Alkaabi JM, Mushtaq A, Al-Maskari Disorders: Characteristics of Non- man K, Wahjono H, Gardjito W, F, Moussa NA, Gariballa S. (2010). Participants and Assessment of Soejoenoes A, Van Den Broek PJ, Hypokalemic periodic paralysis: a Possible Bias. Journal of Medical Keuter M, Gyssens IC, Verbrugh case series, review of the literature Sciences (2010); 3(1): 54-61. HA; Group Antimicrobial Resist- and update of management. Eur ance in Indonesia Prevalence and J Emerg Med, Feb; 17(1):45-7. Blair I. (2010). Children’s Environ- Prevention. (2010). Determinants Review. mental Health. Ibnosina Journal of of carriage of resistant Staphylo- Medicine and Biomedical Sciences coccus aureus among S. aureus Al-Maskari F, El-Sadig M, 2010, 2(5):187-189. carriers in the Indonesian popula- Nagelkerke N. (2010). Assessment tion inside and outside hospi- of the direct medical costs of Blair I. (2010). Defending Against tals. Trop Med Int Health. 2010 diabetes mellitus and its complica- Disasters: Global Public Health Oct;15(10):1235-43. tions in the United Arab Emirates Emergencies and Opportunities (2010). BMC Public Health. Nov 8; for Collaboration and Action. McKinnon LR, Kimani M, Wachihi 10: 679. Asia Pac J Public Health 2010; 22: C, Nagelkerke NJ, Muriuki FK, 222S-228S. Kariri A, Lester RT, Gelmon L, Ball Alsowaidi S, Abdulle A, Bernsen TB, Plummer FA, Kaul R, Kimani J. R, Zuberbier T. (2010). Allergic Conca W, Al-Nuaimi K, Nagelkerke (2010). Effect of baseline HIV dis- rhinitis and asthma: a large cross- N. (2010). The complexity of ease parameters on CD4+ T cell re- sectional study in the United regional warming in the United covery after antiretroviral therapy Arab Emirates. Int Arch Allergy Arab Emirates in the period 1982- initiation in Kenyan women. PLoS Immunol. 2010;153(3):274-9. Epub 2009. Int J. Global Warming 2010; One. 2010 Jul 2;5(7):e11434.PMID: 2010 May 19. 2:225-233. 20625393.

Denic S, Nagelkerke N, Agar- McLean M, Al Ahbabi S, Al Ameri wal MM. (2010). Choice of kin M, Al Mansoori M, Al Yahyaei F,

21 Department of Community Medicine

Bernsen R. (2010). Muslim women Aw TC. (2010). An initiative for pp.236-237. and medical students in the global health in the United Arab clinical encounter. Med Educ. 2010 Emirates (Editorial). Asia-Pacific Published Mar;44(3):306-15. Journal of Public Health. Supp to Abstracts, 22(3):11S. Phuong HL, Nga TT, Giao PT, Hung Aw TC. (2010). Introduction to Letters and le Q, Binh TQ, Nam NV, Nagelkerke Metals. In: Hunter’s Diseases of Correspondence N, de Vries PJ. (2010). Randomised Occupations, 10th edition. Editors: primary health center based inter- Baxter PJ et al. London: Hodder Al-Kaabi JM, Al-Maskari F, Saadi ventions to improve the diagnosis Arnold, pp.151-152. H, Afandi B. (2010). Prevalence of and treatment of undifferentiated peripheral vascular disease among fever and dengue in Vietnam. Aw TC. (2010). The occupational diabetic patients attending the BMC Health Serv Res. 2010 Sep history. In: Hunter’s Diseases of diabetes center at Tawam hospital- 21;10:275. Occupations, 10th edition. Editors: UAE. Diabetes: Journal of the Baxter PJ et al. London: Hodder American Diabetes Association 59 Saadi H, Nagelkerke N, Al-Kaabi Arnold, pp.33-42. (Suppl.1):2367-PO: A620. J, Afandi B, Al-Maskari F, Kazam E. (2010). Screening strategy for Aw TC. (2010). Vibration. In: Oxford Aw TC, Taimur Z, Zaidi M. (2010). type 2 diabetes in the United Arab Textbook of Medicine 5th edition. Using a Delphi approach to deter- Emirates. Asia Pac J Public Health. Editors: Warrell DA, Cox TM, Firth mine UAE occupational health pri- 2010 Jul;22(3 Suppl):54S-59S. JD. Oxford: Oxford University orities. Internal Medicine Journal Press; pp.1434-1436. 40 (Suppl.1):3. Straetemans M, Bierrenbach AL, Nagelkerke N, Glaziou P, van der Aw TC, Blair I. (2010). Occupational Aw TC. (2010). Denis D’Auria: Werf MJ. (2010). The effect of tu- Infections. In: Infectious diseases Former editor of ‘Occupational berculosis on mortality in HIV posi- 3rd edition. Editors: Cohen J, Medicine’. Occupational Medicine tive people: a meta-analysis. PLoS Powderly WG, Opal SM. Oxford: 60(4):324. One. 2010 Dec 30;5(12):e15241. Mosby-Elsevier; pp.715-726. Aw TC. (2010). Supporting doctors Van den Wijngaard CC, van Asten Aw TC, Igisu H. (2010). Tin. In: (Viewpoint). Occupational Health L, Meijer A, van Pelt W, Nagelkerke Hunter’s Diseases of Occupations, at Work. 7(1):24. NJ, Donker GA, van der Sande MA, 10th edition. Editors: Baxter PJ Koopmans MP. (2010). Detection et al. London: Hodder Arnold, Barss P, Grivna M, Al Dhaheri A, of excess influenza severity: asso- pp.238-240. Harrison O. (2010). New death no- ciating respiratory hospitalization tification form and training in the and mortality data with reports Baxter PJ, Aw TC, Cockroft A, Dur- United Arab Emirates as improved of influenza-like illness by pri- rington P, Harrington JM. (2010). sources of data on injury and mary care physicians. Am J Public The changing face of occupational other main causes. Injury Preven- Health. 2010 Nov;100(11):2248-54 diseases. In: Hunter’s Diseases of tion 16 (Suppl.1):A243. Occupations, 10th edition. Editors: Van den Wijngaard CC, van Baxter PJ et al. London: Hodder Bharwani S, Bharwani SS, Kamal Asten L, van Pelt W, Doornbos G, Arnold, pp.24-29. A, Shah SM. (2010). Management Nagelkerke NJ, Donker GA, van practices of H pylori infection in der Hoek W, Koopmans MP. (2010). Baxter PJ, Aw TC, Cockroft A. (2010). the United Arab Emirates. Journal Syndromic surveillance for local Work and stress. In: Hunter’s Dis- of Gastroenterology & Hepatology outbreaks of lower-respiratory in- eases of Occupations, 10th edition. 25 (Suppl.2):A158. fections: would it work? PLoS One. Editors: Baxter PJ et al. London: 2010 Apr 29;5(4):e10406. Hodder Arnold, pp.803. Grivna M, Al-Shamsi H, Al-Ham- madi A, Al-Obthani M, Al-Ali M, k Blair I. (2010). Polonium. In: Hunter’s Al-Senanin A, El-Sadig M, Bernsen Diseases of Occupations, 10th R, Barss P. (2010). Child restraints: edition”. Editors: Baxter PJ et al. Lon- A cross sectional study on Books, Chapters, don: Hodder Arnold, pp231-233. knowledge, attitude and practice of traffic police in United Arab Reviews and Blair I. (2010). Uranium. In: Hunter’s Emirates. Injury Prevention 16 Editorials Diseases of Occupations, 10th (Suppl.1):A241. edition”. Editors: Baxter PJ et al. Lon- Ahmed SM, Aw TC. (2010). Noise. don: Hodder Arnold, pp243-245. Jha P, Kumar R, Khera A, Bhat- In: Oxford Textbook of Medicine tacharya M, Arora P, Gajalakshmi 5th edition. Editors: Warrell DA, Igisu H, Aw TC. (2010). Thallium. V, Bhatia P, Kam D, Bassani DG, Cox TM, Firth JD. Oxford: Oxford In: Hunter’s Diseases of Occupa- Sullivan A, Suraweera W, McLaugh- University Press; pp.1432-1434. tions, 10th edition. Editors: Baxter lin C, Dhingra N, Nagelkerke N; PJ et al. London: Hodder Arnold, Million Death Study Collaborators.

22 Department of Community Medicine

(2010). HIV mortality and infection Arabia, February 13-16, 2010. 2010, Taiwan. April 21-25, 2010. in India: estimates from nationally Al Midfa A, Al Neyadi S, Shah SM. Aw TC. (2010). International representative mortality survey of (2010). Hypertension among perspectives on occupational 1.1 million homes. BMJ. 2010 Feb South Asian women; role of medicine. Department of Commu- 23;340:c621. central obesity. 7th International nity Medicine, Chinese University Scientific Conference for Medical of Hong Kong (CUHK). Hong Kong. Khan G, Rizvi TA, Blair I, Adrian TE. Students in the GCC Countries, August 20, 2010. (2010). Risk of blood-borne infec- Jeddah, Saudi Arabia, February tions in barber shops. J Inf Pub 13-16, 2010. Aw TC. (2010). Introduction to Hlth 2010; 3(2):88-89. occupational medicine. UK Adult Al Naqeeb AA, Al Zahmi AS, ADHD Network conference on Saadi H, Nagelkerke N, Al-Kaabi Al Senani AS, Al Zaabi MR, Al Occupational medicine and Adult J, Afandi B, Al-Maskari F, Kazam Hammadi FE, Al Marashda KY, ADHD. Manchester, UK. July 8, E. (2010). Screening strategy for Al Hosani SM, Al Mazrooei SA, 2010. type 2 diabetes mellitus in the Grivna M, Blair I, Kurdi R. (2010). UAE. Diabetes: Journal of the Knowledge and practice of par- Aw TC. (2010). Occupational health American Diabetes Association 59 ents towards Rota-virus related and safety priorities for the UAE. (Suppl.1):2367-PO:A620. diarrhea in children 0-4 years Report for the Health Authority of of age in Al Ain, UAE. VIII IEA Abu Dhabi. Department of Com- Schneider JD, Bates GP, Nix H. Eastern Mediterranean Regional munity Medicine, UAE University. (2010). Development and valida- Scientific Meeting, Beirut, Leba- tion of guidelines for manag- non, November 25-27, 2010 Aw TC. (2010). Occupational ing work in hot environments hygiene and interpretation of ex- in the Middle East. Internal Al Suwaidi MS, Al Suwaidi AS, Shah posure data. European Forum on Medicine Journal, March 2010 40 S, Al-Maskari F. (2010). Hyperten- Occupational Health, Paramaribo, (Suppl.1):49. sion among South Asian women: Suriname. November 22, 2010. role of mental stress. The 7th Shah SM, Hussain A, Jafar T, Reeder International Scientific Conference Aw TC. (2010). Preparing oc- B. (2010). Obesity in a South Asian for Medical Students in the GCC cupational health and safety population: trends between 1995 Countries, Jeddah, Saudi Arabia, professionals for the challenges of and 2007. Obesity Reviews 11 February 13-16, 2010. tomorrow. Singapore Workplace (Suppl.1):59. Safety & Health Conference 2010, Al-Kaabi JM, Al-Maskari F, Saadi Singapore. September 14-16, 2010. H, Afandi B. (2010). Prevalence of k peripheral vascular disease among Aw TC. (2010). Priorities for well- type 2 diabetics in Al Ain Medical ness in the workplace. Arab Health District. 15th Annual Workshop Congress on Quality Management Proceedings, on Diabetes Mellitus. FMHS, UAE in Healthcare. Dubai, UAE. January Conferences, University, Al Ain, UAE. 28, 2010. Invited Lectures, Al-Kaabi MS, Shah SM. (2010). Aw TC. (2010). Research challenges Web Sites and Cigarette smoking and its corre- and strategies for qualitative and lates among youth in United Arab quantitative research in the United Others Emirates. 5th Emirates Medical Arab Emirates. WUN (Worldwide Students’ Society Conference, Ras Universities Network) workshop Al Dhahei ASM, Al Marzouqi AM, Al Khaimah, 2010. on late presentation of Breast Al Khateri H, Al Merza NMO, Shah cancer. Leeds, UK. November 15, SM, Nagelkerke N. (2010). Physical Al-Maskari F, El-Sadig M, 2010. activity and obesity among el- Nagelkerke N. (2010). The Costs of ementary school children; dispar- Diabetes in the UAE. Global Health Aw TC. (2010). Safety for surgeons, ity across gender. 7th International in the UAE: Asia-Middle East Con- nurses and other hospital staff. So- Scientific Conference for Medical nections Conference, Al Ain, UAE, ciety of Professionals of Infection Students in the GCC Countries, January 4-8, 2010. Control Conference at Ain Shams Jeddah, Saudi Arabia, February University, Cairo, Egypt. October 13-16, 2010. Aw TC. (2010). Approaches to 2-3, 2010. Occupational medicine training. Al Kathiri SM, Butti NA, Shah S, Hong Kong College of Community Aw TC. (2010). Scope of occupa- Agarwal M, Al-Maskari F. (2010). Medicine, Hong Kong. August 19, tional health and occupational Prevalence of diabetes among 2010. medicine. European Forum on Emirati population: role of gender? Occupational Health, Paramaribo, 7th International Scientific Confer- Aw TC. (2010). Compensation for Suriname. November 19, 2010. ence for Medical Students in the occupational diseases and injuries. GCC Countries, Jeddah, Saudi EPICOH-MEDICHEM Conference Aw TC. (2010). The clinical rel-

23 Department of Community Medicine

evance of taking the occupational Proceedings from ICME 2010 – history. Faculty of Medicine, Na- International Conference of Medi- Wheatley A, Grivna M, Abu-Zidan tional University of Malaysia, Kuala cal Education, Abu Dhabi, UAE, F, Al-Kaabi J. (2010). Recent Lumpur, Malaysia. May 19, 2010. December 4-7, 2010. RIDDOR-related initiatives in the United Arab Emirates. British Aw TC. (2010). The importance of Grivna M. (2010). Epidemiology Occupational Hygiene Society recognising occupational diseases. and prevention of child injuries Annual Conference, Harrogate, UK, Faculty of Medicine, Khon Kaen in the UAE: a policy oriented ap- April 27-29, 2010. University, Thailand. May 3, 2010. proach. Arab Children Health Con- gress on Accidents and Injuries: Yeatts KB, Olshan AF, Funk WE, Blair I, Grivna M, Aw TC. (2010). Prevention of Injuries Amongst El-Sadig M, Al-Maskari F, Chan RL, New modular Master of Public Children, Dubai, UAE, March 23- Popkin B, Ng SW, Rusyn I, MacDon- Health programme in the United 25, 2010. ald J, Davis E, Leith D. (2010). The Arab Emirates. ICME 2010 – Inter- United Arab Emirates (UAE) Indoor national conference of Medical Hefny A, Grivna M, Abbas A, Air, Health, and Nutrition Study. Education, Abu Dhabi, UAE, Branicki F, Abu-Zidan F. (2010). 43rd Annual Meeting of the Soci- December 4-7, 2010. Pediatric trauma research in the ety for Epidemiologic Research. Gulf Cooperation Council coun- California, USA. Blair I. (2010). Global Health and tries. 2nd SEHA Annual Research the UAE. Global Health in the UAE: Conference, December 12-13 Zahid N, Shah SM. (2010). Active Asia-Middle East Connections 2010, Abu Dhabi, UAE:81. and passive smoking: a double Conference, Al Ain, UAE, January whammy for women in high 4-8, 2010. Saadi H, Nagelkerke N, Al-Kaabi mountain villages of Pakistan. J, Afandi B, Al-Maskari F, Kazam World Congress of Cardiology, Eid H, Hefny A, Grivna M, Abu- E. (2010). Screening Strategy for Beijing, China, June 16-19, 2010. Zidan F. (2010), Bicycle-related in- Type 2 Diabetes in the United juries in hospitalized patients in a Arab Emirates. Global Health in Zahmi BS, Al Hammadi FM, Al high-income developing country. the UAE: Asia-Middle East Con- Neaimi KR, Dhanhani HS, Shah SM, The 2nd SEHA Annual Research nections Conference, Al Ain, UAE, Schneider S. (2010). Epidemiology Conference, December 12-13, January 4-8, 2010. of Musculoskeletal Symptoms 2010, Abu Dhabi, UAE:98. among medical students in UAE. Saadi H, Nagelkerke N, Al-Kaabi 7th International Scientific Confer- El-Sadig M. (2010). Costs of MVC J, Afandi B, Al-Maskari F, Kazam E. ence for Medical Students in the deaths and injuries in the UAE (2010). Screening strategy for type GCC Countries, Jeddah, Saudi during 2006. Commercial Vehicles 2 diabetes mellitus in the UAE. Arabia, February 13-16, 2010. Conference Middle East 2010, 15th Annual Workshop on Diabe- organized by RTA Dubai at the tes Mellitus. FMHS, UAE University, International Convention Centre, Al Ain, UAE. k Dubai, March 9-10, 2010. Schneider JD, Bates GP. (2010). A El-Sadig M. (2010). Magnitude of comparison of indices for predict- RESEARCH GRANTS motor vehicle crashes, injuries ing heat stress in UAE construction and deaths among children and workers. 9th Professional Develop- FMHS Research Grants adolescents in the UAE. Arab Chil- ment Conference American Soci- dren’s Health Congress 2010: Child ety of Safety Engineers – Middle Prof TC Aw [PI], Dr M Sheek-Hus- Accidents Prevention, Dubai, UAE, East Chapter, Feb 2010; 427-435. sein, Prof L Nasir March 23-25, 2010. Determination and comparison of Shah SM, Agarwal M, Dhatt GS. socio-cultural factors influencing Grivna M, Al-Shamsi I, Al-Suwaidi (2010). Cardiovascular risk fac- delays in seeking help for breast S, Al-Zaabi N, Blair I, Bernsen R. tors among Emirati adults: role cancer. (2010). Child car seat use in the of overweight and obesity? 8th United Arab Emirates: knowledge, International Epidemiology Asso- Drs S Bahrwani [PI], SM Shah attitude and practice of pregnant ciation Regional Meeting, Beirut, Gastric cancer burden in the UAE. women. Proceedings from 2nd Lebanon, November 25-27, 2010. European Safe Community Con- Drs MJ Hashim [PI], SM Shah ference, Reykjavik Iceland, May Shah SM, Hussain A, Nishtar S, Online diabetes health education- 19-20, 2010. Reeder B, Paradis G. (2010). Hyper- a randomized controlled trial. tension on worlds’ roof: preva- Grivna M, Barss P. (2010). Injury lence, awareness, and control from Dr JD Schneider [PI] and safety education as a key 1995 to 2007. World Congress of Pilot survey of expatriate working component of a life-style project Cardiology, Beijing, China, June conditions in Abu Dhabi. & other curricula for medical 16-19, 2010. students in the Middle East. UAE University Individual Grant

24 Department of Community Medicine

Drs M Grivna [PI], P Barss, A Al system for drug and alcohol addic- Corporation. Dhaheri, Adi MMF. tion in the UAE. Women’s awareness, attitude and Provost’s Global Health Research Dr J Lim [PI], Prof TC Aw, Drs KS practice regarding the risk of baby Committee Grant Chia, M Hartman, A Bulgiba, M walkers: a post-interventional Dahlui, CH Yip, N Aishah. study. Dr SM Shah [PI], Prof TC Aw, Drs F The burden of advanced stage Al-Maskari, J Hussain, et al. breast cancer due to delays: Emirates Foundation Grant Developed-developing countries establishing a psychosocial cancer partnership for chronic disease research network between Leeds Drs F Al-Maskari [PI], M Elremeli, S prevention. (UK), Middle East (ME), and South- Al-Hammadi, T Zoubeidi. east Asia. WUN Leeds Research Clarifying the role of vitamin D Health Authority of Abu Dhabi Fund for International Research in management of moderate to se- Grant Collaboration. vere asthma in children. Emirates Foundation Grant. Dr JD Schneider [PI], Prof N Nagelkerke, Drs I Blair, M Sheek- k Drs I Blair [PI], M Tabishat, MA Hussein, S Shaban. Alghorani. Pilot survey of expatriate work- The effect of chronic illness on the ing conditions in Al Ain. Health Emirate family. Emirates Founda- Authority of Abu Dhabi Grant. tion Grant. Others National Rehabilitation Centre Prof TC Aw [PI], Drs F Al-Maskari, J (NRC) Grant Schneider, M El-Sadig. Prof TC Aw [PI], Drs O Osman, I UAE Indoor Air, Health and Nutri- Blair, M Sheek-Hussein, L Nasir. tion Study. University of North (2010). Developing a surveillance Carolina at Chapel Hill and RAND

2010Community Medicine

Standing from left to right: S Shah, A Sharif, M El-Sadig, M Grivna, M Sheek-Hussein, N Nagelkerke, J Schneider, I Blair, M Jamal CK Seated left to right: S Yousif, A Kaljee, R Kurdi, T-C Aw Absent: F Al-Maskari

http://www.fmhs.uaeu.ac.ae/Departments/Community Medicine Tel: 7672000 / Fax: 7672033

25 Department of Family Medicine

Research Profile

Professor & Chair: Family Medicine is a discipline that Prof Laeth Nasir encompasses all aspects of patient care Associate Professor: Dr C Leduc * biomedical, psychological and social. It Dr SC Major emphasizes continuity of care and chronic Dr EAM Prinsloo disease management, via a strong doctor- Dr B Raasch * * Assistant Professor: patient relationship. Primary care also focuses Dr MJ Hashim on health promotion and health education, Dr DM Mirza to empower patients to take responsibility Medical Research Specialist: for their own health. The Family Medicine Ms H Mustafa department focuses on carrying out research Medical Research into these domains. Additionally, as much time Technician: Mr J Cherian is spent teaching students and physicians how Medical Secretary: to practice such patient centered principles, the Ms MC Cetra department also carry out medical education

* till October 2010 research into how one should teach family * * till August 2010 medicine within the Middle East.

Communication Skills for an Arab setting The Family Medicine Department concentrates on communica- tion skills as a key qualitative research area. Dr Deen Mirza is looking into how Arabic language and Muslim culture affects the way in which doctors and students communicate with patients. He has produced a new conceptual model for teaching physi- cians in the Arab world how to communicate with patients- the ‘REACH consultation model for communicating with Arab patients’. He is also carrying out research into how well primary care doctors understand and utilize communication skills concepts in everyday practice. In addition to this he is carrying out a focus group study on Western patients’ experience of bad news delivery in the UAE. Dr Deen Mirza is also developing a new framework to examine how Muslim physicians respond internally to traditional health beliefs that derive from core Islamic belief: the ‘Four Choices Model for responding to religious health beliefs in a Muslim setting’. Dr Jawad Hashim is carrying out research 26 Department of Family Medicine

into which patient-centered ‘micro-skills’ Arab Issues identified and changes implemented in medical students struggle with mastering when Cycle 2: taught communication skills in English. Profes- Students eagerly participated in the focus group sor Laeth Nasir and Dr Stella Major are investi- discussions and offered to assist peers in novice gating Emirati medical students’ perceptions on groups to implement the portfolio. Themes how bad news is broken to patients. identified are 1) willingness to conduct self as- sessment and develop learning plans 2) need for Interactive electronic portfolios to enhance regular face to face feedback with opportunity students’ reflective practice to respond 3) Curiosity and excitement and The Department of Family Medicine has decided caution about formal reflection 4) Frustration to include portfolios as part of the teaching with duplication and non-functional technology strategy. Since the academic year 2009/2010 5) Willingness to interact and share knowledge a four cycle reflective ‘plan, act, revise,’ action and resources with peers. research study involving faculty and students is in progress. The first cycle was completed and Blackboard and other media are being explored data was obtained from 16 student question- as part of the online portfolio. naires, two focus group discussions, two SWOT analysis, minutes of three departmental clerk- ship meetings, assessment reports and written communications from students and faculty members. Definitions and concept clarification informed by extensive literature review guided the development of questionnaires and mod- erators guide for use during the second cycle of the study. Cycle 2 will be completed within the next three months.

Self assessment, reflection and portfolio writing are innovative themes. Implementing these ide- as as practical, acceptable and assessable activi- ties is challenging. The terminologies - reflection and self assessment are confusing. Resource in- tensive activities like formative assessment and Online portfolios in the Family Medicine clerkship feedback are often viewed with suspicion op- posed to an opportunity to achieve excellence. Implementing and harnessing ownership of this process in a culturally diverse setting is chal- Faculty Development in Research Skills lenging. Students find documenting knowledge Institutional development in research capacity and competency gaps difficult, while lecturers, requires support for research skills training. Dr juggling multiple teaching, service and research Jawad Hashim has been conducting research obligations, reluctantly participate in processes workshops for faculty, PhD students, research lacking evidence based benefits. assistants and students. These hands-on tutori- als include step-by-step instructions, visual Achievements and challenges identified in cycle 1: demonstration and practical exercises. Research Tutors: Themes identified include 1) Mentoring, workshops conducted so far include: statisti- 2) on-line interaction and support, 3) preference cal data analysis, randomization, bibliographic of paper format and face to face interaction, 4) citation with Zotero, personal digital assistants complexity of assessment criteria, 5) interpreta- (PDAs) and common errors in statistical analysis. tion of terminology, and 6) labour intensity. Students: Themes identified are 1) tutor sup- Research and Academic Collaboration port, 2) computer technology support, 3) repeti- Dr Adri Prinsloo acts as study leader for residen- tion and duplication, 4) lack of literature search cy students in the Department of Family Medi- skills, 5) time commitment, 6) peer interaction. cine, University of the Free State, South Africa. She is also involved in ongoing research and

27 Department of Family Medicine

rates with different primary care doctors in the UK attached to St George’s University of Lon- don and the University of Edinburgh Medical School, as well as doctors in the family medicine departments of Qatar Petroleum and King Faisal Specialist Hospital and Research Centre (Saudi Arabia).

Professor Laeth Nasir has ongoing research into physician impairment in Arab countries and medical student specialty choice in the UAE. He is also developing a novel depression screening instrument in the Emirates. He is also examining Arab and Western perceptions of cooperative publication with residents and undergraduate ventures in the Middle East within a conceptual students of this department on obesity as well theme called ‘the business of medicine ‘. as trauma related emergency department con- sultations by children in Bloemfontein. She is an Associate Professor Engela A M Prinsloo is International member of the Editorial Board of exploring the use of reflective portfolios, tutor the South African Family Practice Journal and a support and feedback to students in a fam- frequent reviewer of articles for the African Jour- ily medicine clerkship. It is the first time that nal of Primary Healthcare & Family Medicine. students are exposed to reflection and portfolio writing as formal requirement for assessment Dr Stella Major is an Honorary Senior Lecturer and educational purposes. An ongoing action at Imperial College London. She is currently con- research project is being conducted. Dr Prins- tributing to several chapters of a new textbook loo’s other research area is the implementation of General Practice which is being published and use of obesity guidelines in primary health together with her colleagues from Imperial care settings and exploring the perceptions and College, Department of Primary Care and Social attitudes of patients regarding body image and Medicine. After spending 12 years as an aca- demic faculty member at the American Univer- sity of Beirut, she continues to collaborate with family physicians from the American University of Beirut with whom she has a number of pub- lications. In 2010, as one of two representatives from the RCGP (UK) International, she was of- ficially invited to the Lebanon as a guest of the British Foreign Office and the Lebanese Ministry of Health, to explore ways of professionalizing General Practice in Lebanon. Her active col- laboration with Imperial College has led to her travelling to Malaysia as an external examiner risks of obesity. She is also interested in devel- for the Masters in Family Medicine. In 2011, she oping and researching a sustainable conceptual has been awarded Fellowship of the Royal Col- model for experiential teaching sites for Family lege of General Practice – UK. Medicine through collaboration between differ- ent partners including universities, communities Dr Deen M Mirza is the international editor and service providers. for the London Journal of Primary Care, a peer reviewer for Advances in Health Sciences Educa- Associate Professor Stella Major: My research tion and a GP appraiser in the UK. In 2009 he at- interests are influenced by the fact that I am tended the MRCGP International Development both a practicing clinician and an educator. Workshop in the UK. In 2010 he was invited to Since joining the UAEU, I have started look- be an observer for the MRCGP International ing at a variety of issues which are known to clinical exam being held in Dubai. He collabo- present challenges to medical students. As we

28 Department of Family Medicine

are teaching the OSC1 students clinical and ceptions of unprofessionalism in the clinical set- communication skills, my research is looking ting and comparing how well family medicine at the students perceived challenges when residents recognize ‘cases of unprofessionalism’ learning to perform clinical examination of a as compared to medical students. He has pre- patient, and similarly challenges which they sented new methods to insert professionalism might face; when required to break bad news into the ‘hidden curriculum’ of a PBL curriculum. to their patients. At Clinical Clerkship level, our He also carries out research into the MRCGP department has developed an online portfolio International exam held in Dubai, looking at lo- to assist the student learning process, and I join cal primary care doctors’ attitudes to this exam, my colleagues in looking into the impact of this as well as how different modules of the exam on the senior clerkship students learning. As a are assessed. Deen Mirza has also been involved faculty member responsible for providing CME/ in two Diabetes research projects: one investi- CPD to colleagues; I am looking into the practice gating the link between patients’ knowledge of of CME/CPD activities that physicians in the UAE Diabetes and glycaemic control; and another engage in; with a particular emphasis on seeing looking at the role of insulin in Type 2 Diabetic how these activities impact their daily clinical control. decision-making.

Assistant Professor M Jawad Hashim is work- ing on improving health education in the region by studying how patients perceive health mes- sages and how the design and delivery of health education materials can be optimized. He has received a grant from the Emirates Foundation to develop and test educational materials for patients with limited literacy. This mixed meth- ods study will help highlight regional cultural and linguistic factors for patient empowerment for chronic disease self-care. Dr Hashim’s other

research areas include development of tools for assessment of health literacy and design of healthcare symbols for use in navigation of health facilities such as hospitals. Collaborating with researchers in other departments as well as PhD students and visiting scholars, he conducts statistical analysis of data and advises on study design.

Assistant Professor Deen M Mirza is explor- ing doctor-patient communication skills within an Arab setting. He is also carrying out research into professionalism, investigating student per-

29 Department of Family Medicine

Articles in Peer- Published http://jme.bmj.com/letters. reviewed Journals Abstracts, k De Jager GF, Prinsloo EAM, Joubert Letters and G. (2010). Use of traditional medi- Correspondence cine versus use of the community- Proceedings, based primary health care clinic by Hashim MJ. (2010). Sigsearch: a Conferences, the San community at Platfontein new term for post hoc unplanned SA. Fam Pract;52(6):542-547. search for statistically significant Invited Lectures, relationships with the intent to Web Sites and Hashim MJ, Prinsloo EA, Leduc create publishable findings. Ac- C, Raasch B, Mirza DM. (2010). count Res;17(5):270-2. Others What community-based precep- tors want in teaching medical Hashim MJ. (2010). Health literacy Hashim MJ. (2010.). The patient- students: Findings from a mixed research should include patients doctor relationship. Dubai Health methods study. Education for from diverse ethnicities and those Authority First Family Medicine Health;23(2):366. with limited literacy. (29 July symposium, Dubai. 2010) response to Ann Fam Med; Mirza DM, Hashim MJ. (2010). 8: 334-340. Published online at: Hashim MJ. (2010). A new model Communication skills training http://www.annfammed.org/cgi/ for informed consent. Interna- in English alone can leave Arab eletters/8/4/334. tional Conference on Science in medical students unconfident Society, Madrid, Spain. with patient communication in Hashim MJ.( 2010). Health their native language. Education education and preventive care Mirza DM. (2010). How should for Health;23(2):450. among adolescents. response communication skills be adapted to Adolescent Primary Care Visit for Arab patients? Second Annual Mirza DM. (2010). Assessing Patterns Nordin et al. (Ann Fam SEHA Research Conference . professionalism in undergraduates Med 2010) Published online using the MRCGP orals. Medical at: http://www.annfammed. Mirza DM. (2010). Communica- Education; 44(5):509-10. org/cgi/eletters?lookup=by_ tion Skills with Arab Patients. 3rd date&days=60#18383. Middle East Review Course in Prinsloo EAM, Dimpe MW, Primary Healthcare Conference, Maphakisa MV, Matika MD, Sha- Mirza DM. (2010). Islamic opinions Abu Dhabi. balala SLNB, Joubert G. (2010). differ regarding physical contact Doctors’ use of laboratory tests between genders within a doctor- Mirza DM. ( 2009). Leduc C, in the diagnosis and treatment patient encounter. Letter to the Hashim J, Al-Shekaili OA, Al-Awadi of patients. South Afr J Epidemiol Editor. Journal of Medical Ethics. FA, Aal-Ali SO, Al-Kindi F, Al-Naqbi Infect;25(3):16-20. Published online at http://jme. JO, Al-Naqbi ZM. Correlating Type bmj.com/letters. 2 diabetic control with manage- ment stage in Al Ain primary care. k Mirza DM. (2010).Reflection 1st Annual Seha research confer- depends on culture as much as ence. on language. Letter to the Editor. Books, Chapters, Medical Humanities. Published on- Mirza DM. (2009). The language line at http://mh.bmj.com/letters. of instruction for communication Reviews and skills training in the UAE. The 10th Editorials Mirza DM. (2010). Are UK com- Annual Research Conference of munication curricula applicable UAE University. Ellis C. (Apr 2009).Pharmaceutical throughout the world? Letter to Latin. S Afr Med J.;99(4):222. the Editor. Medical Education; Mirza DM. (2009). A New Method 44(5):529-30. for Teaching Professionalism Ellis C. (2009). Consulting with within a PBL Curriculum; 6th Asia veiled students. BMJ; 339:b2664. Mirza DM. (2010). Promoting Pacific Medical Education Confer- unprofessionalism in the UAE? ence, Singapore. Paulman PM, Paulman A, Harrison Letter to the Editor. Education for JD, Nasir LS, Bryan SK. (2010). Primary Care;21(2):132. Prinsloo EAM, J. Hashim, B Raasch, Signs and symptoms in fam- S Major. (2010).Implementing an ily practice: a literature-based Prinsloo E. (2010). Teaching and online portfolio with a reflective approach in family medicine. assessing doctors competent to component as formal requirement Elsevier, Mosby, ISBN: 978-0-323- consult both Muslim and non- in a Family Medicine Clerkship: 04981-8. Muslim patients Journal of Medical Achievements and Challenges. Ethics. E-Letter, published online at The Network: TUFH conference in k Kathmandu Nepal.

30 Department of Family Medicine

Prinsloo E, Hashim J. (2010). Imple- Emirates Foundation Grant menting the use of online portfo- RESEARCH GRANTS lio in a PHC based Family Medicine Dr MJ Hashim (2009). Health FMHS Research Grant clerkship – using a plan, do, revise education for patients with limited (reflective learning) cycle in a Prof TC Aw (PI), Dr M Sheek- literacy. student and educator population Hussein, Prof L Nasir, Dr T Zoubeidi previously never exposed to the et al (2010). Determination and UAEU Global Health Institute portfolios as reflective learning comparison of socio-cultural fac- Grants tools. The Network: TUFH confer- tors influencing delays in seeking ence in Kathmandu Nepal. help for breast cancer. Drs R Mollica (PI). Dr O Osman, Prof L Nasir (2010) (Co-PIs). Build- Raasch B, McLean M. (2010). ing Capacity and Partnership For Changes and Adaptations to an Drs DM Mirza (PI), C Leduc (2009). Excellence in Mental Health: A Introductory Clinical Skills module Assessing insulin initiation in type joint Collaboration Between UAEU in an Undergraduate Medical 2 diabetics in primary care. and Harvard Program on Refugee Program. 7th Asia Pacific Medical Trauma- HPRT. Education Conference Singapore. UAEU Individual Grant Dr Syed M Shah (PI), MJ Hashim. MJ Hashim (2009). Effectiveness of (2010). Developed Developing a new model for communication Countries’ (DDC) Partnership k skills teaching for Arabic-speaking for Non-communicable Disease medical students. Prevention.

2010Family Medicine

Standing left to right: Mr J Cherian, Dr C Leduc, Dr D Mirza, Dr J Hashim. Seated left to right: Dr B Raasch, Dr SC Major, Prof LS Nasir, Dr EAM Prinsloo, Ms MC Cetra, Ms H Mustafa.

http://www.fmhs.uaeu.ac.ae/Departments/Community Medicine Tel: 7672000 / Fax: 7672033

31 Department of Internal Medicine

Research Profile

Professor & Chair: The Department of Internal Medicine has Prof H Saadi witnessed a substantial growth in number Professor: Prof J Braun of faculty and staff during the year 2010. Our Prof I Galadari Department is now composed of 17 faculty, Prof S Gariballa 2 teaching assistants, 5 research staff and 3 Prof E E Kazzam Associate Professor: administrative staff. We are deeply committed Dr W Conca to our research mission. Since high quality Dr S Denic research activities enhance clinical and Dr I Hassan Assistant Professor: education missions, faculty engage in basic Dr A Al Dhanhani and clinical research. This work includes Dr A Al-Fazari epidemiological studies, randomized clinical Dr J Alkaabi Dr S Alkaram trials, case control studies, studies using large Dr S Al-Shamsi databases, qualitative research and computer Dr S Al-Suwaidi simulation studies. Dr H Galadari Dr M Al Houqani We conduct research in most priority areas including: Dr A Shehab Teaching Assistant (Abroad) Acute and chronic leukaemia Dr G Al Mansouri Allergies Dr F Al-Shamsi Cardiovascular disease Medical Research Specialist: Chronic renal failure Dr A M Abdulle Consanguinity studies Dr B Al-Dabbagh Dermatology Mr J Yasin Diabetes and metabolism Medical Research Assistant: Hypertension Ms V Doctor Nutrition and obesity Research Nurse: Osteoporosis Mr A Alessa Population genetics Administrative Assistant: Rheumatic disease Mr H Hassan Sleep apnea Secretary: Thalassemia and sickle cell disease Ms R John Ms S Ogilvie

32 Department of Internal Medicine

Stroke: The novel, non-toxic broad spectrum caspase inhibitor Q-VD-OPH attenuates stroke-induced decrease in lymphocyte counts. Control mice were sham-operated. Stroke was induced by MCAO for 45 min and mice were treated with either vehicle (DMSO) or caspase-inhibitor Q-VD-OPH (500 μg). Thymus, spleens, and blood were collected 3 days after stroke. (Provided by Prof. Braun.)

Meningitis: Hippocampal damage in pneumococcal meningitis is reduced in E2F1-/- mice. Twenty hours following intrathecal injection of Streptococcus pneumoniae in wild type (b, f, j) and knockout mice (d, h, l) damage of dentate gyrus neurons was assessed with H&E (a - d), TUNEL (e - h), and active caspase-3 immunohistochemistry (i - l). Wild type (a, e, i) and knockout (c, g, k) control animals were injected intrathecally with PBS. Bar = 50 μm. (Provided by Prof. Braun.)

33 Department of Internal Medicine

Articles in Peer- reviewed Journals Abdulle AM, Pathan JY, Moussa N, Gariballa S. (2010). Association be- tween homocysteine and endothe- lial dysfunction markers in stroke disease. Nutritional Neuroscience 13(1); 2-6.

Alkaabi JM, Mushtaq A, Al-Maskari FN, Moussa NA, Gariballa S. (2010). Hypokalemic periodic paralysis: A case series, review of the litera- ture and update of management. European Journal of Emergency Medicine 17(1); 45-47.

Al-Samri MT, Al-Shamsi M, Al-Salam S, Marzouqi F, Al-Mansouri A, Al- Hammadi S, Balhaj G, Al-Dawaar SKM, Ruqayya SMS, Al-Hanjeri RSMS, Benedict S, Sudhadevi M, Conca W, Penefsky HS, Souid A-K. (2010). Measurement of oxygen Meningitis: Hippocampal damage in pneumococcal meningitis is reduced in E2F1-/- consumption by murine tissues In mice. Twenty hours following intrathecal injection of Streptococcus pneumoniae in Vitro. Journal of Pharmacological wild type (b, f, j) and knockout mice (d, h, l) damage of dentate gyrus neurons was assessed with H&E (a - d), TUNEL (e - h), and active caspase-3 immunohistochemistry and Toxicological Methods Oct 27. (i - l). Wild type (a, e, i) and knockout (c, g, k) control animals were injected (Epub ahead of print). intrathecally with PBS. Bar = 50 μm. (Provided by Prof. Braun.) Al-Shamsi M, Al-Samri M, Al-Salam S, Conca W, Shaban S, Benedict S, Tariq S, Biradar A, Penefsky HS, Asefa T, Souid AK. (2010). Bio- compatibility of calcined mesopo- rous silica particles with cellular bioenergetics in murine tissues. Chemical Research in Toxicology 23; 1796-1805.

Alsowaidi S, Abdulle A, Bernsen R, T. Zuberbier. (2010). Allergic rhinitis and asthma: A large cross sectional study in the United Arab Emirates. International Archives of Allergy and Immunology 153; 274-279.

Alsowaidi S, Abdulle A, Zuberbier T, Bernsen R. (2010). Allergic rhinitis: Prevalence and possible risk factors in a Gulf Arab population. Allergy 65; 208-212.

Alsowaidi S, Abdulle A, Bernsen R. (2010). Prevalence and risk factors of asthma among adolescents and their parents in Al-Ain (United Arab Emirates). Respiration 79; 105-111.

Alsowaidi A, AlHana A, Zarouni K, Al Zaabi A, Abdulle A. (2010).

34 Department of Internal Medicine

Anaphylactic patient characteris- (2010). Bacterial transferase MraY tics, clinical features, and current inhibitors: Synthesis and biological Published practice in the Emergency Unit. evaluation. Bioorganic & Medicinal Abstracts, Biomedical Research 21(4); 406- Chemistry 18(12); 4560-4569. 410. Letters and Marras TK, Mehta M, Chedore P, Correspondence Braun JS. (2010). Ataxia, hypoa- May K, Houqani MA, Jamieson F. cusis, and dementia. British (2010). Nontuberculous mycobac- Adrian TE, Gariballa S, Parekh KA, Medical Journal doi:10.1136/ terial lung infections in Ontario, Thomas SA, Saadi H, Al Kaabi J, bcr.10.2009.2399. (On-line). Canada: Clinical and microbio- Nagelkerke N, Gedulin BR, Young logical characteristics. Lung. AA. (2010). Can Diabetes be Braun JS. (2010). Ecto-5’-nucleoti- Aug;188(4); 289-299. treated through the rectum? dase-positive cells in the choroid Diabetologia 53 (Suppl 1) S44. and ciliary body of the rat eye. The Obineche E, Abdulle A, Pathan Anatomical Record 293; 379-382. J, Nagelkerke N. (2010). Plasma Al Houqani M, Jamieson F, endothelin-1, homocysteine, and Chedore P, Mehta M, May K, Marras Conca W, Kamel SA, Venne D, Corr nitric oxide levels in a multiethnic TK. (2010). Population changes P. (2010). Transient involvement hypertensive cohort from the may explain recent increases in of the cerebral cortex in a flare of United Arab Emirates. Journal of pulmonary mycobacterium avium Behçet’s disease. Rheumatology Medical Sciences 3; 153-159. complex disease in Ontario. Am. J. International Jan 7 (Epub ahead of Respir. Crit. Care Med., May 2010; print). Saadi H, Al-Kaabi J, Afandi B, Al- 181: A6803. Maskari F, Kazzam E, Nagelkerke N. Conca W, Al-Nuaimi K, Nagelkerke (2010). Screening strategy for dia- Braun JS. (2010). Stroke therapy N. (2010). The complexity of re- betes mellitus in the United Arab strategy change: How to achieve gional warming in the United Arab Emirates. Asia Pac J Public Health neuroprotection. International Emirates in the period 1982-2009. Jul 22(3 Suppl); 54S-59S. Journal of Stroke 5; 234. International Journal of Global Warming 2; 225-233. Tanino T, Ichikawa S, Al-Dabbagh Denic S, Nagelkerke N, Agarwal B, Bouhss A, Oyama H, Matsuda MM. (2010). On some novel as- Denic S, Nagelkerke N, Agarwal A. (2010). Synthesis and biologi- pects of consanguineous marriag- MM. (2010). On some novel as- cal evaluation of muraymycin es: Response to A.H. Bittles. Public pects of consanguineous marriag- analogues active against anti-drug- Health Genomics. Dec 10. (Epub es. Public Health Genomics. Dec resistant bacteria. ACS Medicinal ahead of print). 10. (Epub ahead of print). Chemistry Letters 1(6); 258-262. Saadi H, Afandi B, Al-Kaabi J. Denic S, Nagelkerke N, Agar- (2010). Prevalence of diabetes wal MM. (2010). Choice of kin in mellitus and its complications in consanguineous marriages: Effects k a population-based sample in Al of altruism and ecological factors. Ain, United Arab Emirates. Com- Ann Hum Biol. Nov 37(6); 738-753. mentary in Health and Diabetes; (Epub Mar 31). Books, Chapters, Jordan Arabic Magazine. July. Li K, Ichikawa S, Al-Dabbagh B, Reviews and Bouhss A, Matsuda A. (2010). Function-oriented synthesis of sim- Editorials k plified caprazamycins: Discovery of oxazolidine-containing uridine Denic S, Nagelkerke N, Agarwal derivatives as antibacterial agents MM. (2010). On differing aspects Proceedings, against drug-resistant bacteria. and perception of consanguine- Journal of Medicinal Chemistry ous marriages. In: Jaworski JA (ed). Conferences, 53(9); 3793-3813. Advances in Sociology Research. Invited Lectures Volume 6. Nova Science Publishers, Kamel S, Al-Kaabi J, Ellis M, Garib- New York. and Others alla S. (2010). Pulmonary nocar- diosis masquerading as severe Gariballa SE. (2010). Human Nutri- Al-Dabbagh B, Barreteau H, Blanot community-acquired pneumonia. tion, Geissler and Powers 12th Edi- D, Bostock J, Bouhss A, Chopra I, European Journal of Emergency tion. Elsevier Churchill Livingstone, Crouvoisier M, Hervé M, Mengin- Medicine 17(5); 302-303. ISBN 0443073562, Volume 12, pp Lecreulx D, Olantunji S, Patin D, 342 - 350. Touzé T. (2010). Recent advances Lecerclé D, Clouet A, Al-Dabbagh in the study of the MurD, MurF, B, Crouvoisier M, Bouhss A, MraY, MurG and WecA enzymes. Gravier-Pelletier C, Le Merrer Y. k European Commission FP6 Pro- gram: Inhibition of new targets for

35 Department of Internal Medicine

fighting antibiotic resistance (EUR- Federation of Neurology. Geneva, (2010). Global health conference. INTAFAR) 9th General Assembly. Switzerland. 26 September. Al Ain, United Arab Emirates. Paris, France. March. Kazzam E. (2010). Second World January. Heart Failure. Chandigarh, India. Adrian TE, Gariballa S, Parekh KA, (Invited Faculty). Thomas SA, Saadi H, Al Kaabi J, k Nagelkerke N, Gedulin B, Young Kazzam E. (2010). Right ventricu- AA. (2010). The bile acid brake: A lar failure. Second World Heart novel target for treating diabetes Failure. Chandigarh, India. RESEARCH GRANTS and obesity. 46th EASD Annual Meeting. Stockholm. 20-24 Sep- Kazzam E. (2010). Heart failure in FMHS Research Grants tember. the Middle East: Update and litera- ture review. Second World Heart Dr W Conca (PI) Alkaabi J, Al-Dabbagh B, Ahmad Failure. Chandigarh, India. Impaired hepatocellular bioener- S, Saadi H, Gariballa S, Al Ghazali getics in concanavalin A-induced M. (2010). Glycemic indices of five Kazzam E. (2010). Assessment of murine hepatitis. (2009-2010). varieties of dates in healthy and right ventricular function. Albert diabetic subjects. 2nd Annual Einstein Medical Center. Philadel- Prof E Kazzam (PI) SEHA Research Conference. Abu phia, Pennsylvania, USA. Cardiac function in patients with Dhabi, United Arab Emirates. thalassemia major with special December. Kazzam E. (2010). 26th Annual In- emphasis on right ventricular ternational Conference on Recent remodeling and pulmonary hyper- Braun JS. (2010). Update cerebro- Advances in Echocardiography tension. spinal fluid diagnostics guidelines. and Allied Techniques (MRI, CT ABx Program Meeting. Berlin, Scan and Nuclear). Atlanta, USA. Prof H Saadi (PI) Germany. A longitudinal study of the effect Lobsien E, Gaus V, Schaumann A, of high dose prenatal vitamin D Braun JS. (2010). Anti-infective Braun JS. (2010). Chronic otitis supplementation on the physical therapy in neurology. Update in externa with lumbar mass and growth and incidence of lower Neurology. Charité University, progredient vigilance reduction. respiratory tract infection in the Berlin, Germany. 27th Congress of the German offspring during the first year of Society for Neurointensive and life. (2009-2010). Dawodu A, Saadi HF, Bekdache Emergency Medicine, Bad Hom- G, Altaye M, Hollis BW. (2010). burg, Germany. UAEU Individual Grants Extraordinary high prevalence of vitamin D deficiency without Saadi HF, Dawodu A, Bekdache G, Prof E Kazzam (PI) seasonal variation in pregnant Altaye M, Benedict S, Hollis BW. Epidemiology, risk factors, and Arab women. Presented at Pedi- (2010). A randomized controlled consequences of obstructive sleep atric Academic Societies Annual trial of prenatal vitamin D sup- apnea and short sleep duration: meeting in Vancouver, Canada. plementation to prevent vitamin Special emphasis on cardiovascu- 1-4 May. D deficiency in mothers and their lar disease and neurohormonal infants: interim results. Proceed- activation. Denic S, Souid K-A, Nagelkerke ings of the 92nd Annual Meeting N, Showqi S. (2010). Erythrocyte of The Endocrine Society. San Emirates Foundation phenotypes in Emirati people with Diego, CA. June. α+ Thalassemia. 15th Congress Prof S Gariballa (PI), Drs J Alkaabi, of the European Hematology As- Saadi H. (2010). Lifestyle modifica- H Ali. sociation. Barcelona, Spain. 10-13 tion for morbid obesity: Is it effec- An interventional study of the ef- June. tive? (2010). The second SKMC- fects of a healthy diet and physical Cleveland Clinic Annual Obesity activity on knowledge, attitude Gariballa S. (2010). Homo- Symposium. Abu Dhabi, United and health of obese Emirati cysteine and mental health in Arab Emirates. 16 Oct. subjects and their spouses. (2010- older patients: A randomised 2012). double-blind placebo-controlled Saadi H. (2010). Screening strategy trial. Platform presentation. BGS for diabetes in the UAE. (2010). Prof E Kazzam (PI) Edinburgh, UK. 15th Annual workshop on dia- Cardiac remodeling and ven- betes mellitus. (2010). Faculty of tricular interaction in patients Gariballa S. (2010). Role of Medicine and Health Sciences. Al with thalassemia major: Detailed nutrition in pathophysiology of Ain, United Arab Emirates. echocardiographic and magnetic cerebral ischaemia. 14th Con- resonance imaging evaluation in gress of the European Federation Saadi H. (2010). Screening for relation to neurohormones and of Neurological Society / World diabetes: experience in the UAE. collagen markers.

36 Department of Internal Medicine

Prof H Saadi (PI) Others National survey of diabetes and its complications in the United Dr AM Abdulle. Arab Emirates - Abu Dhabi Phase. United Arab Emirates Armed (2010). Forces Emirates child obesity study. k

2010Internal Medicine

Standing left to right: AM Abdulle, Mr J Yasin, Dr B Al-Dabbagh, Mr H Hassan, Mrs S Ogilvie, Ms R John, Mr Abubaker, Mr A Al-Essa, Dr W Conca Seated left to right: Dr A Al Fazari, Dr S Denic, Dr I Hassan, Professor S Gariballa, Professor H Saadi, Professor I Galadari, Dr J Alkaabi, Dr H Galadari

http://www.fmhs.uaeu.ac.ae/Departments/InternalMedicine Tel: 7672000 / Fax: 7672995

37 Department of Medical Education

Research Profile

Professor & Chair: The main research activities of the Department Prof Mutairu Ezimokhai of Medical Education can be found in the Professor: Prof M McLean MERGE (Medical Education Research Group) Assistant Professor: report. Research that has been completed or is Dr S Shaban in progress in the department includes: Medical Skills and Communication Lectures: Ms G Kershaw Dr R Benner Mutairu Ezimokhai’s research interests include pre-term labour Mr M Campbell and polycystic ovarian syndrome. Administrative Assistants: Ms H Mansour Michelle McLean’s main research includes transferable skills, Mr CP Nair students’ perceptions of learning, reflection and self-assessment Mr M Nazimuddin and learner-centred education. Ms N Seifelnasr Secretary: Sami Shaban’s research interests are in Health Informatics and Ms S Lal electronic curriculum systems for medical education. Office Assistant: Mr T Usman Summary of current research projects

MEDIA CENTER 1. Medical students’ perceptions of their first encounter in AV Specialist: the Anatomy dissection room: McLean, Shehab (Anatomy) Mr M Yassin 2. High-achieving medical students’ perceptions of their suc- Graphic Designer: cess: McLean Ms I Lizarriturri 3. Student and staff perceptions of faculty evaluation: Photographer: Aburawi (Paediatrics), Shaban, McLean Mr A Prasad 4. Preparedness for medical practice: Final year medical stu- Reprographic Technician: dents, McLean Mr M Aboobacker 5. Effective use of a medical school curriculum management system for the Faculty of Medicine and Health Sciences, UAEU. A SKILLS AND TEACHING database-driven secure website allows multiple level access for LABORAORY administrators, faculty, and students. Features include manag- Clinical Skills Coordinator: ing teaching session information, student attendance, instructor Ms M Sudhir conflict display, and timetabling of sessions. [http://www.fmhs. Laboratory Supervisor: uaeu.ac.ae/fmhscms/] (Shaban). Mr K Unnikrishnan 6. Effective use of a electronic assessment for the Faculty of Mr A Wahab Medicine and Health Sciences, UAEU. Electronic assessment Laboratory Assistant: involves question management and data banks as well as assess- Mr B Abubakkar ment delivery and analysis (Shaban). Mr S Pandian

38 Department of Medical Education

Shaban S, Marzouqi F, Al Mansouri B, Major S, McLean M. (2010). Articles in Peer- A, Penefsky HF, Souid AK. (2010). Implementing an online portfolio reviewed Journals Oxygen measurements via phos- with a reflective component as phorescence. Computer Methods formal requirement in a Family Al Shamsi M, Al Samri MT, Al Salam and Programs in Biomedicine, Medicine Clerkship: Achievements S, Conca W, Shaban S, Benedict 100:3, December 2010. and challenges. The Network: TUFH S, Tariq S, Biradar A, Penefsky HS, Conference, 13-17 November 2010, Asefa T, Souid AK. (2010). Biocom- Shaban S, Eid HO, Barka E, Abu-Zi- Kathmandu. patibility of Calcined Mesopo- dan FM. (2010). Towards a national rous Silica Particles with Cellular trauma registry for the United Raasch BA, McLean M. (2010). Bioenergetics in Murine Tissues. Arab Emirates. BMC Research Changes and adaptations to an Chemical Research in Toxicology. Notes. 2010;3:187. introductory clinical skills mod- Accepted 2010. ule in an undergraduate medical program. 7th Asia Pacific Medical Jaber L, Shaban S, and Hariri D. k Education Conference, 4-8 February (2010). Oral cancer prevention and 2010, Singapore. early detection: Knowledge and practice among Saudi Arabian Proceedings, Shaban S. (2010). A curriculum healthcare practitioners. Inter- Conferences, management system for integrated national Journal of Health Care medical education. International Quality Assurance. (Accepted for Invited Lectures Conference in Medical Education, publication Jan 2010). and Others Abu Dhabi, UAE, December 2010. Jaber L, Shaban S, Hariri D, and Marzouqi F, Al-Mansouri A, Shaban Shaban S. (2010). The design and Smith S. (2010). Perceptions of S, Penefsky HS, Souid AK. (2010). development of a medical school healthcare practitioners in saudi Oxygen measurement via phospho- curriculum management sys- arabia regarding their training in rescence: Biological applications. tem. International Conference on oral cancer prevention, and early 7th Scientific Conference for Medi- Education, Training and Informatics, detection. International Journal cal Students in the GCC Countries. Orlando, USA, April 2010. of Health Care Quality Assurance, King Abdulaziz University, Jeddah, 2010;24(1). Saudi Arabia, February 2010. Shaban S. (2010). Electronic Medical Record (EMR) benefits and adoption McLean M, Al Ahbabi S, Al Ameri McLean M, Shaban S. (2010). De- challenges, Al Ain Hospital man- M, Al Mansoori M, Al Yahyaei F, velopment of transferable skills: A aged by Vienna Medical University Bernsen R. (2010). Muslim women three-year study of first year Emirati and VAMED. SEHA Conference, Al and medical students in the medical students. Association of Ain, March 2010. clinical encounter: A United Arab Medical Education in Europe, 4-8 Emirates study. Medical Education, September, Glasgow. 44; 306-315. k McLean M. (2010). Transferable McLean M, Gibbs T. (2010). Twelve Skills: A Gulf Perspective. First Zayed tips to designing and implement- University Conference on Learning ing a learner-centred curriculum: and Teaching in the Gulf. Dubai, Prevention is better than cure. UAE, 18 March 2010. Medical Teacher 32; 225-230. McLean M. (2010). Faculty Devel- McLean M. (2010). Scholarship, pub- opment, Association of Medical lication, and career advancement in Education in Europe, Glasgow, 5-8 health professions education. Guide September 2010. Supplement 43.1 – Viewpoint 1. Medical Teacher 32; 526-529. McLean M. (2010). Why we need basic sciences and their integration McLean M. (2010). Citizens for an into effective curricula. Damascus unknown future: Developing ge- University, Syria, 23-25 October neric skills and capabilities: A Gulf 2010. perspective. Learning & Teaching in Higher Education: Gulf Perspec- McLean M. (2010). You are noth- tives 7(2); 9-31. ing without effective faculty: The importance of faculty development. McLean M. (2010). How to profes- Damascus University, Syria, 23-25 sionalise your practice as a health October 2010. professions educator. Medical Teacher 32; 953-955. Prinsloo EAM, Hashim J, Raasch

39 Department of Medical Education

Medical Education 2010 Standing left to right: Mr T Usman, Mr K Pandian, Mr M Yassin, Dr S Shaban, Mr M Campbell, Mr M Aboobacker, Dr R Benner, Mr CP Nair, Mr K Unnikrishnan, Mr M Nazimuddin, Mr A Prasad. Seated left to right: Professor M McLean, Ms N S Al Nasr, Ms G Kershaw, Professor M Ezimokhai, Ms I Lizarriturri, Ms S Lal, Ms Sudhir. Absent: Mr A Wahab, Mr B Abubakkar.

http://www.fmhs.uaeu.ac.ae/Departments/Medical Education Tel: 7672000 / Fax: 7672167

40 Department of Medical Microbiology & Immunology

Research Profile

The Department continues to build on a Professor & Chair number of demonstrated areas of research Prof Basel al-Ramadi Prof M Lukic* strengths in the fields of immunology, Professor immunoparasitology, virology and Prof S Dissanayake bacteriology. Prof T Pal Prof T A Rizvi Associate Professor Dr G Khan During the year 2010, the departmental graduate program Assistant Professor expanded with the awarding of two UAE University PhD Scholar- Dr A Al-Qahtani ships to graduate students being supervised by Professors Tahir Dr M Al-Shamsi Rizvi and Basel al-Ramadi. Currently the Department has a total Dr A Sonnevend of eight graduate students (four PhDs and four MSc) and it is Medical Research Specialist anticipated that more students will join by the start of the 2011 Ms L M Ali academic year. Since the start of the graduate program, four Ms A Al-Ghazawi students have already completed the course of studies for the Mr A Al-Haj M.Sc degree and defended their thesis. Two of these students are Ms M Ibrahim pursuing their PhD studies in Canada and Germany. Ms P S Philip Mr A Shahin In 2010, four students defended their thesis and three more are Medical Research Technician expected to do so in the first trimester of 2011. Ms G Bashir Medical Secretary The Department was also successful in securing two National Ms M Dawood Research Foundation grants (through UAE University) which were Office Assistant awarded to Professors Rizvi and al-Ramadi. The funds will un- Mr H Mohammed doubtedly help in maintaining the strength of research programs in the Department. *Departed in October 2010

In addition to graduate students, the Department is increasingly involved in hosting foreign postgraduate medical trainees as they fulfill their specialist training in microbiology or immunology by carrying out research work in the Department. These relatively short periods of training are helping to build bridges with the trainee’s institutions in Europe and the Middle East.

Several members of the Department continue to build on scientific collaborations with laboratories in Europe and North America. These efforts have lead to high-quality publications in top journals such as Nature Structural and Molecular Biology (Dr

41 Department of Medical Microbiology & Immunology

Al-Qhatani), Cancer Cell (Dr Khan) and Arthritis expression. With respect to IFN-γ, one specific and Rheumatism (Dr Al-Shamsi). area of research is negative regulation of TLR signaling. Long-term objective is development Professor Basel al-Ramadi: One of the major of synthetic immunoadjuvants with defined research interests in our laboratory is focused Th-1 and Th-2 immunomodulatory properties. on exploring the role of the innate immune Based on the previous finding (Figure 2) that system in the host’s response to infections and terminal β-(1-4) galactose residues on GlcNAc cancer. Through the use of genetically modified backbones is an epitope regulating IFN-γ (a Th-1 mouse strains, the influence of deficiencies in cytokine), a panel of synthetic glycans is being components of the Toll-like receptor and Nod- investigated for further development as adju- like receptor pathways on the host’s response vants. In tuberculosis research, epidemiological to infection is being investigated. In another re- studies are being carried out to determine the search focus, we have utilized cytokine-express- source(s) of infection, patterns of transmission ing bacterial strains as a means of boosting and the possible causes of likely re-activation in the immune response to tumor challenge. We long-term residents of UAE. have shown that this form of immunotherapy is active when given orally, which is of signifi- Dr G Khan: Cancer is one of the leading causes cant benefit as it decreases the toxicity often of death in UAE, and indeed the world. Thus, associated with systemic cytokine therapies research focused on understanding the aeti- (see Figure 1). A third focus of research is the ology and pathogenesis of cancer is of para- development of composite nanoparticles as im- mount interest. Viruses are now believed to be munotherapy tools of various chronic diseases involved, directly or indirectly, in the patho- as well as for anti-infective treatment. genesis of approximately 15% of all human malignancies, accounting for around 1.5 million Professor S. Dissanayake’s research interests cases worldwide. Most of these cases are due are in parasite glycan immunobiology and tu- to just 6 viruses: HTLV-1, HPV, Hepatitis B and C, berculosis. Current emphasis in glycan immu- HHV-8 and EBV. The main focus of interest in my nobiology is on molecular characterization of laboratory is to understand the mechanisms by parasite glycans with respect to upregulation of which some of these viruses lead to cell trans- the transcription factor NF-κB and signaling ef- formation and proliferation. We are particularly fects and mechanisms leading to IFN-γ and IL-6 interested in EBV. This virus is well known for

Figure 1 Inhibition of tumor growth and enhanced host survival following oral treatment with attenuated S. typhimurium expressing TNF-α. Mice were implanted s.c. with B16 melanoma cells and 13 days later tumor-bearing mice were given an oral inoculum of 4x108 CFUs/mouse of either attenuated Salmonella (strain BRD509) or TNF-α expressing recombinant Salmonella strain (designated GIDTNF). Growth of tumor (A) and animal survival (B) were subsequently followed for up to 30 days. Each data point represents the mean ± SEM of 10 mice per group. Asterisks denote statistically significant differences from saline control group (**, p<0.01; *, p<0.05).

42 Department of Medical Microbiology & Immunology

Figure 2 A. Pre-stimulation abolishes Taenia glycan Fr1 induced IFN-γ response. A: Mice were prestimulated by intraperitoneal injection of 0.5 OD 280 U of Taenia glycan and spleen cells were stimulated in vitro culture at day 1, 3, 7 and 20 post stimulation. Numbers above bars indicate the post stimulation day and N= naïve animals. = Naïve cells + Con A; = Naïve cells + glycan; = post day 7 + Con A; = post day 7+ glycan. B: Oral feeding of BALB/c mice with Taenia glycan Fr1 induced down regulation of spleen cell IFN-γ in response to in-vitro stimulation. C-Con A: control spleen cells + Con A, Td5-Con A: Taenia Fr1oral fed day 5+ Con A, Td-7 Con A: Taenia Fr1 oral fed day 7 + Con A, C-Lex: Control spleen cells + Lewis X, Td5-Le X: Taenia Fr1 oral fed day 5+ Le X, Td7-Le X: Taenia Fr1 oral fed day 7+ Lex, C-Fr 1: control spleen cells + Taenia Fr1, Td5-Fr1: Taenia Fr1 oral fed day 5+ Taenia Fr1, Td7- Fr1: Taenia Fr1 oral fed day 7 + Taenia Fr1. its oncogenic properties and it is associated Professor T Pal: The main research area in my with a number of human malignancies of both laboratory is studying the molecular epidemi- epithelial and lymphoid origin. We are trying to ology and genetic background of antibiotic understand the role of some of the viral latent resistance in Gram negative organisms, in products in regulating latency, inhibition of particular Acinetobacter baumannii and Entero- apoptosis and cell proliferation. Other ongoing bacteriaceae. In order to reveal the dynamics of projects in my laboratory include, investiga- nosocomial outbreaks caused by these bacte- tions into the role of the recently discovered ria we fingerprint them in an attempt to find oncogenic viruses, XMRV and MCV and their out their key features to spread and survive in association with human malignancies. On a hospitals. We compare sporadic and outbreak broader level, we have interests in viral diseases strains in a variety of in vivo and in vitro models relevant to public health. In this context, we to learn whether there are any other features recently carried out a comprehensive study of beyond antibiotic resistance in the latter group the pandemic 2009 H1N1 in the Emirate of Abu contributing to their fitness. Lately we focus Dhabi (see figure 3). increasingly on genes coding for a group of en-

Figure 3: Pandemic 2009 H1N1 in the Emirate of Abu Dhabi. (A) Distribution of cases of influenza-like illness, laboratory confirmed 2009 H1N1 (survivors), and H1N1-associated deaths from May 2009 to March 2010 in the Emirate of Abu Dhabi. A total of 2806 cases were reported to the Health Authority Abu Dhabi. Of these, 1872 were ILI (H1N1-negative or status unknown), 908 were confirmed H1N1 (survivors) and 26 were H1N1-associated deaths. ILI and confirmed H1N1 (survivors) are plotted by date of first presentation. H1N1 fatalities are plotted by date of death. (b) Distribution of cases of influenza-like illness and laboratory confirmed 2009 H1N1 cases by age from May 2009 to March 2010. (From Khan et al, Emerging Infectious Diseases 17:292-5, 2011).

43 Department of Medical Microbiology & Immunology

Figure 4. Conjugal transfer of New Delhi Metallo-beta lactamse gene- carrying plasmids from clinical isolates of Escherichia coli and Klebsiella pneumonia. Lane desgination is as follows: MW1 and 2: Plasmid molecular weight markers; D1-D4: clinical isolate plasmid donors; T1-T4: transconjugants; R: recipient. Carbapenem S and R: Carbapenem susceptible and resist- ant; blaNDM1: New Delhi metallo-beta lactamase gene (as detected by PCR)

zymes called metallo-beta lactamases. Recently, the almost unprecedented fastness of spread of one of these genes (blaNDM-1) among enteric bacteria caused worldwide concerns. We found the same genes in Acinetobacter, as well as have shown that it is easily transferable, albeit with an unknown mechanism (Fig. 4). We believe that these efforts will lead to a better understanding, and hence better control and prevention of anti- biotic resistance among bacterial pathogens.

Professor T A Rizvi: The focus of Professor Rizvi’s research concerns the basic steps in retroviral replication with the ultimate goal of developing improved retroviral vector systems for human gene therapy. Specifically Prof. Rizvi’s laboratory is attempting to unravel how retroviruses/lentiviruses package their genomic RNAs into a virus particle and what are some of the underlying differences in RNA packag- ing among retroviruses/lentiviruses. Over the years, these studies have included a number of retroviruses/lentiviruses including, HIV, SIV, FIV, MPMV, and MMTV. Recently these studies have been further expanded to include analyses of cross- and co-packaging among retroviruses/ lentiviruses. Professor Rizvi has been very successful in acquiring both extramural and in- tramural grant support for his work on retroviral RNA packaging. In addition Prof. Rizvi has been very active in supervising and mentoring both Figure 5: the graduate and undergraduate student. His RNA secondary structural model of the 5’ end of MPMV RNA genome recently proposed by Prof. Rizvi’s group (Jaballah et al., J. Mol. current studies on RNA packaging have been Biol., 401: 996-1014, 2010). The region used for folding predictions published in journals of international repute included sequences from R up to 120 nt of Gag and the structure (Fig. 5). was predicted by computer modeling using Mfold, which uses free-energy minimization algorithms (ΔG = −124.70 kcal/mol). The Mfold predicted structure redrawn using XRNA program showing five Dr. Ahmed Al-Qahtani’s research interests conserved stem loops (SLs) and two possible U5/Gag LRI regions, a compromise of studying the mechanism of au- 14-nt G–C-rich palindromic (pal) sequence, which acquires a stem loop motif labeled as pal SL, and a noticeable single stranded purine toimmunity, antibodies diversity and stem cell rich (ssPurine-rich) sequence. Sequences in orange, green, red, and role in bio regenerative medicine. blue represent the primer binding site (PBS), region A, region B, and pal sequences, respectively. Boxed area in purple show the predicted LRIs between U5 and Gag. SD, splice donor. Dr Mariam Al-Shamsi’s main research activity is in the area of inflammation and autoimmuni-

44 Department of Medical Microbiology & Immunology

Figure 6 showing measurement of oxygen consumption by liver pieces of C57BL/c mice collected 3, 6 and 12 hours following treatment with 20mg/kg of ConA or PBS alone. The figures clearly show significant enhancements in O2 consumption in pieces of liver tissues in Con A-treated mice over time.

ty. Her current work is on evaluating the use of In a recent experiment, we noted significant oxygen consumption measurement by cells in enhancements in O2 consumption in pieces vitro as a tool to monitor the status of an inflam- of liver tissues in Con A-treated mice over time matory process in response to a therapeutic in- (see Figure 6). A critical study of the pathologi- tervention. Therefore, we are trying to provide cal presentation accompanied by analyzing O2 evidence here that measurement of oxygen consumption following intravenous injections consumption in inflammatory conditions using of Con A with and without treatment with an conA-induced hepatitis model can be utilized as anti-inflammatory reagent will follow. a tool to evaluate progression or alleviation of Together with a collaboration from the depart- the pathological condition following treatment. ment of Anatomy, Dr. Mariam is also continu- This suggestion relies on the fact that Immune ing the work that have started to study the reactions are very important energy consumers suspected anti-inflammatory role of IL-27 in where ATP is the principle immediate donor of the pathogenesis of MLD-STZ induced type 1 free energy and oxidation of fuel molecules to diabetes (fig. 7). Our unexpected finding of the drive oxidative phosphorylation is the major opposite that in our MLD-STZ induced type 1 source of ATP. ATP-dependent cellular functions diabetes that IL-27 is rather proinflammatory is include normal functions of immune cells such coming to an end with further evidence of our as lymphocytes and macrophages in response findings. Below is the figure (Fig. 7) showing to antigen exposure. These functions include, number of infiltrating cells and a paraffin sec- synthesis of cytokines, antigen processing and tion of a pancreatic islet showing infiltration as presentation, cellular migration to inflammatory well as a study on caspase 3 positively stained cites, effector functions and other responses. cells indicating apoptosis.

Figure 7/1 Average number of infiltrating cells counted in islet of similar sizes of STZ only or STZ+IL-27. Figure 7/2 a. a micrograph showing H&E stained paraffin sections of an islet from an untreated mouse, b. treated with STZ only and, c. treated with STZ+IL-27.

Figure 7/3 Micrograph showing immunohistochemically stained islets of caspase 3 positive cells in STZ only and STZ+IL27 treated mice. Note the significantly (p <0.005) greater number of apoptotic cells in islets of IL-27 treated mice (40 ±7) (b) when compared with islets of control mice treated with STZ only (22 ± 6) (a).

45 Department of Medical Microbiology & Immunology

Dr A Sonnevend-Pal’s main research activi- Articles in Peer- ties are in the area of molecular epidemiology and antibiotic sensitivity of human pathogenic reviewed Journals bacteria. She studies polyresistant pathogenic Adeghate E, Fernandez-Cabezudo bacteria like methicillin resistant Staphylococ- M, Hameed R, El-Hasasna H, El- cus aureus (MRSA), extended spectrum beta Wasila M, Abbas T, al-Ramadi B. lactamase (ESBL) and carbapenemese producer (2010). Orexin-1 receptor co-local- Escherichia and other Enterobacteriaceae, which izes with pancreatic hormones in islet cells and modulates the out- are the major threat in the hospitals in the UAE come of streptozotocin-induced and becoming more and more prevalent in the diabetes mellitus. PLoS ONE, 5(1): community, as well (Fig. 8). Also, in cooperation e8587. with Prof. T Pal, she investigates the molecular epidemiology of Acinetobacter baumannii in Al-Shamsi M, Al-Samri M, Al-Salam S, Conca W, Benedict S, Sudhadevi the UAE. Beyond that she cooperates extensively M, Biradar A, Asefa T, Souid A. with Prof. JM Conlon studying the effect of vari- (2010). Biocompatibility study of ous peptides on different antibiotic resistant mesoporous silicate particles with microorganisms. cellular bioenergetics in murine tissues. Chem. Res. Toxicol, 11:1796-805.

Conlon JM, Ahmed E, Pal T, Son- nevend A. (2010). Potent and rapid bactericidal activity of alyteserin 1c and its [E4K] analog against multidrug resistant strains of Aci- netobacter baumannii. Peptides. 31; 1806-10.

Conlon JM, Sonnevend A. (2010). Antimicrobial peptides in frog skin secretions. Methods Mol Bio, 618; 3-14.

Conlon M, Ahmed E, Pál T, Son- nevend A. (2010). Potent and rapid bactericidal action of alyteserin- 1c and its [E4K] analog against multidrug-resistant strains of Aci- netobacter baumannii. Peptides, 31; 1806-1810. Figure 8: Protein A sequence based typing of Staphylococcus aureus Fernandez-Cabezudo MJ, Lorke DE, Azimullah S, Mechkarska M, Hasan MY, Petroianu GA, al- Ramadi BK. (2010). Cholinergic stimulation of the immune system protects against lethal infection by Salmonella enteric sero- var Typhimurium. Immunology, 130:388-398.

Jaballah SA, Aktar SJ, Ali J, Phillip PS, Al Dhaheri NS, Jabeen A, Rizvi TA. (2010). A G-C rich palindromic structural motif and a stretch of single stranded purines are required for optimal packaging of Mason-Pfizer monkey virus (MPMV) genomic RNA. J. Mol. Biol., 401: 996-1014.

46 Department of Medical Microbiology & Immunology

Jamal W, Rotimi VO, Pál T, Son- complications of diabetes mellitus. nol. 228(1/2); 163-164. nevend A, Dimitrov TS. (2010). Stem Cells, 2010 Nov 9. [Epub Volarevic V, Al-Qahtani A, Arseni- Comparative in vitro activity of ahead of print] jevic N, Pajovic S, Lukic ML. (2010). tigecycline and other antimicrobi- Interleukin-1 receptor antagonist al agents against Shigella species Xu Z, Fulop Z, Wu G, Pone EJ, (IL-1Ra) and IL-1Ra producing mes- from Kuwait and the United Arab Zhang J, Mai T, Thomas LM, enchymal stem cells as modula- of Emirates. J. Infect Public Health, Al-Qahtani A, White CA, Park SR, tors of diabetogenesis.Autoimmu- 3; 35-42. Steinacker P, Li Z, Yates J 3rd, Her- nity, 2010 Jun;43(4):255-63. ron B, Otto M, Zan H, Fu H, Casali Maciejewska-Rodrigues H, Al- P. (2010). 14-3-3 adaptor proteins Volarevic V, Arsenijevic N, Lukic Shamisi M, Hemmatazad H, Ospelt recruit AID to 5’-AGCT-3’-rich ML, Stojkovic M. (2010). Mesen- C, Bouton MC, Jager D, Cope AP, switch regions for class switch chymal stem cell treatment of the Charles P, Plant D, Distler JH, Gay recombination. Nat Struct Mol complications of diabetes mellitus. RE, Michel BA, Knuth A, Neidhart Biol, 2010 Sep;17(9):1124-35. Epub Stem Cells, 2010 Nov 9. [Epub M, Gay S, Jungel A. (2010). Func- 2010 Aug 22. ahead of print] tional autoantibodies against Serpin E2 in rheumatoid arthritis. Zan H, Zhang J, Al-Qahtani A, Pone Arthritis Rheum. 62; 93-104. EJ, White CA, Lee D, Yel L, Mai T, k Casali P. (2010) Endonuclease G Mensah-Brown EP, Shahin A, Al plays a role in immunoglobulin Shamisi M, Lukic ML (2010). Early class switch DNA recombination Proceedings, influx of macrophages determines by introducing double-strand susceptibility to experimental breaks in switch regions. Mol Conferences, allergic encephalomyelitis in Dark Immunol, 2011 Jan;48(4):610-22. Invited Lectures, Agouti (DA) rats. J Neuroimmu- Epub 2010 Nov 26. nol, 2010 Nov 23. [Epub ahead of Web Sites and print]. k Others Puyol M, Martin A, Dubus P, Khan G, Guerra C, Santamaria D, Bar- al-Ramadi, BK. (2010). 1st North bacid M. (2010). A synthetic lethal Published American Primary Immune interaction between K-Ras onco- Deficiency National Conference, genes and Cdk4 unveils a thera- Abstracts, Philadelphia, PA, USA. (20-23 May, peutic strategic for the treatment Letters and 2010). of non small cell lung carcinoma. Cancer Cell, 18: 63-73. Correspondence al-Ramadi, BK. (2010). Regula- tion of the Immune Response to Rizvi TA, Kenyon JC, Ali J, Aktar Intracellular Bacteria. Department Khan G, Rizvi TR, Blair I, Adrian T of Cellular Biology & Pharmacol- SJ, Phillip PS, Ghazawi A, Mus- (2010). Risk of blood-borne infec- tafa F, Lever AML. (2010). Optimal ogy, Herbert Wertheim College tions in barber shops in the UAE. J of Medicine, Florida International packaging of FIV genomic RNA Infect Public Health, 3; 88-9. depends upon a conserved long- University, Miami, FL, USA (De- cember 16, 2010). range interaction and a palindro- Khan G. (2010). High incidence mic sequence within gag. J. Mol. of Epstein-Barr virus infection Biol, 403; 103-119. al-Ramadi, BK. (2010). The MyD88 in childhood acute lymphocytic protein: a key regulator of im- leukemia. Indian J Pathol Micro- mune responses. Immunotherapy Tzartos J, Khan G, Vossenkamper biol, 53; 890-1. A, Meager A, Sefia E, Middledorp Division, University of Michigan J, Giovannoni G, Meier UC. (2010). School of Medicine, Ann Arbor, MI, Pone EJ, Zan H, Zhang J, Al-Qahta- USA (September 2, 2010). Activation of innate immunity is ni A, Xu Z, Casali P. (2010) Toll-like a hallmark of the active lesion in receptors and B-cell receptors syn- al-Ramadi, BK, Azimullah S, El-Ojali multiple sclerosis. J Neuroimmu- ergize to induce immunoglobulin nol, 228(1/2); 163-164. S, Issac JM, Al-Ketbi MI, Fernandez- class-switch DNA recombination: Cabezudo MJ. (2010). Role of relevance to microbial antibody Vila J, Pál T. (2010). Update on anti- MyD88 Protein in Host-Pathogen responses. Crit Rev Immunol, Interactions. 50th Annual Meeting bacterial resistance in low-income 2010;30(1):1-29. countries: Factors favoring the of the American Society for Cell emergence of resistance. Open Inf Biology, Philadelphia, PA, USA Tzartos j, Khan G, Vossenkamper (December 11-15, 2010). Dis J, 4; 38-54. A, Meager A, Sefia E, Middledorp J, Giovannoni G, Meier UC. (2010). Fahim M.A., Karam S, al-Ramadi Volarevic V, Arsenijevic N, Lukic Activation of innate immunity is ML, Stojkovic M. (2010). Mesen- B. (2010). Ghrelin enhances the a hallmark of the active lesion in regenerative potential of stem chymal stem cell treatment of the multiple sclerosis. J Neuroimmu-

47 Department of Medical Microbiology & Immunology

cells. Experimental Biology 2010, Pál, T. (2010). Molecular detection UAE University Seed Grant Anaheim, CA, USA. (April 24-28, of pathogenic microorganisms – 2010). Arab Health, Dubai, 2010. Dr Ahmed Al-Qahtani (PI) N-acetylglucosamine (G1cNAc) role in the treatment of Type I Fernandez-Cabezudo MJ, Az- Pál, T. (2010). Antibiotic Resistance Diabetes Mellitus. imullah S, Al-Barazie R, Lorke D, in Developing Countries - Abu Shehab S, Hasan M, Petroianu G, Dhabi Medical Congress 2010. al-Ramadi BK. (2010). Differential UAEU Individual Grant Immunoregulatory Effects of Two Sonnevend A. (2010). Community Dr Agnes. Sonnevend (PI) Organophospahte Compounds, Acquired vs. Hospital Acquired Prevalence of the international Es- Diisopropyl fluorophosphates and MRSA How different they are? , cherichia coli clone O25:H4-ST131 Paraoxon, on the Host’s Response 6th Middle East Infection Control amongst extended spectrum to Infection. 50th Annual Meet- Conference, Abu Dhabi, October beta-lactamase producer urinary ing of the American Society for 2010. tract isolates of Tawam Hospital, Cell Biology, Philadelphia, PA, USA Al Ain. (December 11-15, 2010). Sonnevend A. (2010). Recent Advances in Molecular Typing of Dr Gulfaraz Khan (PI) Issa, B., I.M. Obaidat, S. Qadri, B. Pathogens, Arab Health Congress, Role of EBV-LMP-1 and EGFR al-Ramadi, Haik Y. (2010). NMR Re- 2010, Dubai gene expression in Emirati breast laxation of Mn0.5Zn0.5GdxFe(2-x) cancer. O4 Hyperthermia Nanoparticles: Sonnevend, Á, El-Kurd S, Alkaabi Effects of Coating. Joint An- M, Al-Haj M, Gazawi A, Akawi N, nual Meeting of the International Pal T. (2010). Prevalence of the UAEU Interdisciplinary Grant Society for Magnetic Resonance ST131 clone among extended Profs Tibor Pal (PI), Basel al-Ram- in Medicine and the European spectrum beta-lactamase produc- adi, Dr Agnes Sonnevend, Prof Society for Magnetic Resonance ing urinary tract Escherichia coli Mohamed Fahim, Drs Mohammed in Medicine and Biology (ISMRM- isolates in the United Arab Emir- Al-Kaabi, Mohammed Abdulmajid ESMRMB), Stockholm, Sweden ates - 12th WPCCID Singapore, Virulence of the nosocomial path- (May 1-7, 2010). 2010 ogen Acinetobacter baumannii. Julia K, Tanner S, Legiewicz M, Phil- lip PS, Rizvi TA, Grice SL, Lever A. k Sheikh Hamdan Award for (2010). High-throughput SHAPE Medical Sciences analysis of FIV packaging signal Prof Tahir Rizvi (PI) structure and RNA dimerization. RESEARCH GRANTS Prevalence of HPV in cervical can- Presented at the spring meeting cer among UAE nationals. of the Society for General Microbi- ology, Edinburgh, 2010. FMHS Research Grants Terry Fox Fund for Cancer Khan G, Al-Mutawa J, Hashim J. Dr Agnes Sonnevend (PI) Research (2010). Pandemic 2009 H1N1 influ- Regulation of biofilm ormationf in Prof Basel al-Ramadi (PI), Dr Maria enza one year on: Abu Dhabi, UAE. a community acquired methicillin Fernandez-Cabezudo NZMS & NZSBMB Annual Meeting, resistant Staphylococcus aureus Cytokine-expressing Salmo- Auckland, 30 Nov - 3 Dec 2010. (CA-MRSA) clone. nella strains as effective biological therapy against cancer: analysis of Pál T, Sonnevend Á, Gazali A, Al- Dr Gulfaraz Khan (PI) the mechanisms underlying the Mounthari N, Al-Haj M, M Ibrahim, Determination of the impact inhibition of tumor growth. Belal SE. (2010). Characterization of EBV on apoptosis of Burkitt’s of sporadic and outbreak strains of lymphoma cell lines in response Dr Maria Fernandez-Cabezudo Acinetobacter baumannii isolated cyototoxic drugs. (PI), Prof Basel al-Ramadi, Drs in Abu Dhabi hospitals - 12th Hakam El-Taji, Mohamed Jaloudi WPCCID Singapore, 2010 Dr Tibor Pal (PI) Characterization of a locally preva- and Haytham El-Salhat Novel resistance biomarkers in Pál T. (2010). Detection of antimi- lent multidrug resistant Acineto- human breast cancer. crobial resistance in low-resource bacter baumannii epidemic clone settings. Meet the expert session, different from globally distributed Prof Tahir Rizvi (PI) ECCMID, Vienna, 2010. ones. Characterization of the Sequences Necessary for Mouse Mammary Pál, T. (2010). Management of Prof Tahir Rizvi (PI) Tumor Virus (MMTV) RNA Packag- Gram-Negative MDRO – Extended Role of palindromic (pal) ing: Implications for the Develop- Spectrum Beta Lactamase Produc- sequence(s) in mouse mammary ment of MMTV-based Vectors for ing Bacteria (ESBL), Acinetobacter - tumor virus (MMTV) RNA dimeri- Cancer Gene Therapy. Abu Dhabi Medical Congress 2010. zation and packaging.

48 Department of Medical Microbiology & Immunology

National Research Foundation and their Mechanism of Action: National Cancer Institute, Grant Implications for the Development National Institutes of Health, of MPMV Vectors for Human Gene USA Prof Basel al-Ramadi (PI), Dr Maria Therapy. Fernandez-Cabezudo Prof Yousef Haik, Prof Basel al- Inactivation of myeloid-derived Ramadi suppressor cells as a novel target Dubai Harvard Foundation for Nanoparticles for Noninvasive for enhancing cancer immuno- Medical Research Thermometry Monitoring therapy. Prof Raif Geha, Luigi Notarangelo, Prof Tahir A. Rizvi (PI) S. Al-Hammadi, Prof Basel al- k Co-packaging and recombina- Ramadi tion among genetically distinct Collaborative Research Network retroviruses: Implications for the on Primary Immunodeficiency development of retroviral vectors Diseases for gene therapy. British Council, UK Emirates Foundation Grant Prof Richard W. Bowtell, Yousef Prof Tahir Rizvi (PI) Haik, Bashar Issa, Prof Basel al- Fine Mapping of Sequences Im- Ramadi portant for Mason Pfizer Monkey Imaging-guided hyperthermia Virus (MPMV) RNA Packaging therapy

2010Medical Microbiology

Standing left to right: Prof Basel al-Ramadi, Prof Tibor Pal, Prof Miodrag Lukic, Dr Gulfaraz Khan, Prof Senarath Dis- sanayake. Seated left to right: Prof Tahir A Rizvi, Mr Hussain Hasasna, Mr Mohamed Hashik, Ms Maureen Dawood, Dr Mariam Al-Shamsi, Dr Agnes Sonnevend Pal, Mr Allen Shahin. http://www.fmhs.uaeu.ac.ae/Departments/Microbiology Tel: 7672000 / Fax: 7671966

49 Department of Obstetrics & Gynaecology

Research Profile

Associate Professor The Research interests in the department & Acting Chair are in Obstetrics, Fetal Medicine, Gynecology Dr H Mirghani Associate Professor oncology, and Urogynecology. Dr J Bodner Assistant Professor: Dr H Elbiss Dr H Mirghani’s major area of research interest is Dr SJ George t
'FUBM
HSPXUI
BOE
QIZTJPMPHZ
JO
EJBCFUJD
QSFHOBODZ
Medical Research Specialist t
'FUBM
BOPNBMJFT
Mrs. FD Lone t
*OWJUSP
IVNBO
QMBDFOUB
QFSGVTJPO
Dr. N Osman Dr K Bodner’s major area of research interest is t
(ZOBFDPMPHZ
PODPMPHZ
t
8PNFO
)FBMUI

Dr H Elbiss’s major area of research interest is t
6SPHZOFDPMPHZ
t
*OWJUSP
IVNBO
QMBDFOUB
QFSGVTJPO
t
.JOJNBM
BDDFTT
TVSHFSZ

Dr S George’s major area of research interest is t
8PNFOT
)FBMUI
t
1PMZDZTUJD
0WBSZ
4ZOESPNF
t
.JOJNBM
BDDFTT
TVSHFSZ

The In-Vitro Placental Perfusion: A model to study the fetal environment The Department of Obstetrics & Gynaecology inaugurated its Placenta Perfusion Lab. The placenta mediates the exchange of nutrients and waste products. It also transfers environmental pol- lutants and drugs from the mother to the fetus. Pregnant women with medical conditions, such as gestational diabetes and hypertension, require drug therapy that can effectively treat the mother without adversely affecting the fetus. As experimentation during pregnancy is ethically unjustified, the technique of human placental perfusion is the widely accepted method to study drug transport and determine its safety to the fetus.

50 Department of Obstetrics & Gynaecology

Articles in Peer- reviewed Journals Alshami HA, Kadasne AR, Khalfan M, Iqbal SZ, Mirghani HM. (2010). Pregnancy outcome in late mater- nal age in a high-income develop- ing country. Arch Gynecol Obstet. 2010 Dec 28. [Epub ahead of print]

Bekdache GN, Begum M, Al-Gazali L, Ali BR, Akawi NA, Mirghani H. (2010). Prenatal diagnosis of thanatophoric dysplasia and obstetrical challenges. J Obstet Gynaecol. 2010;30(6):628-30.

Begam M, Bekdache GN, Murthy SK, Mirghani HM. (2010). Double aneuploidy of trisomy 18 and Klinefelter syndrome: prenatal di- agnosis and perinatal outcome. J Perinat Med. 2010 Sep;38(5):565-6.

Bodner K, Wierrani F, W, Bodner- Adler B. (2010). Influence of the mode of delivery on maternal and neonatal outcomes: a comparison between elective cesarean section and planned vaginal delivery in a low-risk obstetric population. Arch Gynecol Obstet 2010 May 27 (Epub ahead of print)

Bodner K, Laubichler PKimberger O, Czerwenka K, Zeillinger R, Bod- ner-Adler B. (2010). Oestrogen and progesterone receptor expression in patients with adenocarcinoma of the uterine cervix and correla- tion with various clinicopathologic parameters. Anticancer Research 30(4):1341-1345.

Bodner K, Laubichler P, Kimberger O, Czerwenka K, Zeillinger R, Bodner-Adler B. (2010). Expres- sion of p16 protein and epider- The Department of Obstetrics & Gynaecology at UAEU has mal growth factor receptor in established the first human placenta perfusion laboratory in patients with adenocarcinoma of the uterine cervix: an immunhis- UAE. The lab is collaborating with Dr. Antione Malek from the tochemical analysis. Arch Gynecol University Hospital of Zurich, who visited our lab in December Obstet 2010 Apr 20 (Epub ahead 2010. The department is planning for a three years phased of print) study on the function of the placenta in pregnant women with gestational diabetes. It will also investigate the safety of Bodner K, Bodner-Adler B, Gruen- berger W. (2010). Evaluation of the antibiotics in pregnancy. contraceptive efficacy, compli- ance, and satisfaction with the transdermal contraceptive patch system EVRA: a comparison be- tween adolescent and adult users.

51 Department of Obstetrics & Gynaecology

Arch Gynecol Obstet 2010 Jan 29 infection during third trimes- (Epub ahead of print) Proceedings, ter pregnancy in United Arab Conferences, Emirates. Jahrestagung 2010 der Elbiss HM, Thomson AJM, Moran OEGGG (Annual meeting of the PA. (2010). How useful are the Invited Lectures, Austrian Society for Obstetrics and BSUG database outcome criteria: Web Sites and Gynecology), Zell am See, Austria. Validation using the MESA ques- tionnaire. Journal of Obstetrics Others Mirghani H, Bekdache G, Begam and Gynaecology, 2010; 30(7):716- M, Khan F. (2010). Pregestational 720. Bodner K. (2010). Oestrogen and diabetes mellitus: A need for a progesterone receptor expression fetal clinic. 5th Gulf International Hamdan MA, Begam M, Mirghani in patients with adenocarcinoma Congress in Obstetrics & Gnyae- HM. (2010). Inseparable thoraco- of the uterine cervix and correla- cology. Jeddah, Saudi Arabia. omphalopagus twins. Pediatr tion with various clinicopathologic Cardiol. 2010 Nov;31(8):1252-3. parameters. XIX. Wissenschaftli- Mirghani H. (2010). Effect of che Tagung der Arbeitsgruppe maternal fasting during Ramadan Hamdan MA, El-Zoabi BA, Begam Gynäkologische Onkologie (AGO), on the fetus. 5th Gulf International MA, Mirghani HM, Almalik MH. 8. Österreichischer Kongress Congress in Obstetrics & Gnyae- (2010). Antenatal diagnosis of KREBS BEI DER FRAU (Austrian cology. Jeddah, Saudi Arabia. pompe disease by fetal echocardi- Gynecologic Oncology Confer- ography: impact on outcome after ence), Salzburg, Austria. Mirghani H, Bekdache G, Begam early initiation of enzyme replace- M, Khan F. (2010). Fetal measure- ment therapy. J Inherit Metab Dis. Bodner K. (2010). Expression of ments and growth in pregesta- 2010 Sep 4. [Epub ahead of print] p16 protein and epidermal growth tional diabetes mellitus. 20th factor receptor in patients with World Congress on Ultrasound adenocarcinoma of the uterine in Obstetrics and Gynecology, k cervix: an immunhistochemical Prague, Czech Republic. analysis. Jahrestagung 2010 der OEGGG (Annual meeting of the Mirghani H. (2010). Intrauterine Austrian Society for Obstetrics and fetal blood transfusion. 6th Inter- Gynecology), Zell am See, Austria. national Scientific meeting of the International Society for Ultra- Bodner-Adler B, Bodner K. (2010). sound in Obstetrics and Gynecol- Report of 2 maternal mortalities ogy, Cairo, Egypt. with different modes of delivery due to H1N1 2009 influenza virus k

2010Obs & Gyn http://www.fmhs.uaeu.ac.ae/Departments/Microbiology Tel: 7672000 / Fax: 7671966

52 Department of Paediatrics

Research Profile

The research strengths of the department Acting Chairman comprise basic science research, genetics, Dr H Narchi Professor epidemiological studies of important problems Prof Y M Abdulrazzaq * to the UAE (nutrition, growth, vitamin D, Prof L Al-Gazali etc.) as well as in most paediatric specialties Prof A Souid * Associate Professor (haematology, oncology, neonatology, Dr E Aburawi imaging, gastroenterology, infectious diseases, Dr S Bharwani cardiology, etc.) This has been made possible Dr H Narchi Assistant Professor by the clinical expertise of our faculty in the Dr G Balhaj vast range of paediatric conditions and their Dr S Al-Hammadi perceived needs of the patients they are Dr F Al-Jasmi Dr R Al- Mahmoud managing on a daily basis in UAE hospitals and Dr M Al-Samri clinics. Dr A Al-Suwaidi Teaching Assistant Dr F Ismail Research Medical Specialist On-site work in the paediatric laboratory is supporting not only Dr S Benedict basic sciences research, but also collaborative clinical and epide- Mr J Kochiyil miological work in the affiliated hospitals and in the community Mr T Pramathan at large. The expertise and dedication of our medical research Medical Secretary specialists in our laboratory have been instrumental to the re- Ms R Clemente search productivity of the department. * On Sabbatical Leave Paediatric faculty are also actively engaged in collaborative re- search works with other FMHS clinical and basic sciences depart- ments, as well as other UAEU colleges (nutrition, physics, etc.) Networking with other universities and medical institutions in many countries is also ongoing and helps enhance the research visibility and output of the faculty. Many faculty are also serv- ing on the editorial board of several international peer reviewed medical journals, in addition to helping as reviewers.

Aiming towards enhancing the research productivity in child health issues of importance to the country, the paediatric depart- ment has been very proactive in supporting and encouraging the involvement of hospital colleagues in collaborative research

53 Department of Paediatrics

work. We have also involved paediatric residents was established that methionine was 5 times with the objective of equipping them with lower in embryo of treated pregnant mice than the knowledge and experience in carrying out in non-treated controls. Studies are ongoing to research of importance to child health in the determine the impact of folic acid and vitamin UAE once they become established paediatri- B12 supplementation on the frequency of oc- cians. The department efforts in this endeavour currence of anomalies in animal models. have included research workshops for hospital colleagues and paediatric residents (research t
"øBUPYJOT
BSF
DPNNPOMZ
GPVOE
JO
OVUT
methodology, biostatistics, bibliography man- grains and have been found to be increased in agement, etc.) These efforts have been worth- pregnant women and their offspring. Study is while as many non-faculty colleagues have been ongoing to determine teratogenic effects of cited as co-authors in many of our department’s aflatoxins in mice. medical publications. t
5IF
EFQBSUNFOU
JT
BMTP
JOUFSFTUFE
JO
NBQQJOH
The department has also been very active at recessive genetic disorders using the concept projecting the research strengths and output of homozygosity mapping, particularly dis- of the FMHS. Prof. A.K. Souid has contributed as orders which are common or unique to this an advisor to the Researcher newsletter and Dr. population. For example, a gene for Joubert H. Narchi was instrumental in the conception, syndrome, which seems to be common in design and in “populating” the FMHS Medical Arabs, was mapped to chromosome 9q34.3 and Research website. genetic heterogeneity was established. Sub- sequently other genes for Joubert Syndrome Genetics/birth defects (including neuro- were mapped and mutations were identified in genetics) (Y Abdulrazzaq and L al Gazali) families from UAE. Another new type of epiphy- t
5IF
EFQBSUNFOU
IBT
B
TUSPOH
SFTFBSDI
JOUFS- seal dysplasia was described in a family from est in the area of birth defect/dysmorphology UAE and a gene was mapped to chromosome and brain malformations including nervous 15q26. Several other disorders are currently be- system dysgenesis. Several disorders have been ing investigated using the same concept. studied at the clinical and molecular level. For example, familial and sporadic forms of cer- t
.FUBCPMJD
EJTPSEFST
BSF
DPNNPO
JO
UIF
6"&
ebral dysgenesis were studied and a new type The department is active in establishing the of agyria-pachygyria associated with agenesis prevalence of different metabolic disorders in of corpus callosum was characterized, a severe the UAE population. form of a syndrome of myotonia and bone dysplasia [Stüve-Wiedemann Syndrome (SWS)] t
"
TUVEZ
IBT
BMSFBEZ
EFUFSNJOFE
UIF
QSFWBMFODF
was identified to be common in the population of alcaptonuria in the UAE population. of the UAE. Founder mutation in the Leukemia inhibitory factor receptor (LIFR) was found in all Foetal growth (H Narchi, A Skinner, B families affected with SWS in this population. A Williams) birth defect registry for Al Ain Medical District t
4FWFSBM
DPMMBCPSBUJWF
TUVEJFT
XJUI
6,
IPTQJ- was established by the department, which has tals have looked at the evaluation of foetal gained membership of the International Clear- growth by customised birth weight centiles. ing House for Birth Defects. Several studies from The results have shown a better identification this register were published identifying the inci- of outcomes associated with small and large for dence and pattern of the various types of birth gestational age as defined by the customized defects in this population together with estab- centiles. Similar results have also been shown lishing risk factors involved in their etiology. for macrosomic infants and infants born to diabetic mothers. The results have important t
*O
BEEJUJPO
UIF
HSPVQ
IBT
CFFO
JOWFTUJHBU- implications for the screening and monitoring ing the reasons why some anti-epileptic drugs of infants at risk. (vigabatrin, lamotrigine) ingested by women during pregnancy cause neural tube and other Perinatal nutrition and nutritional disorders defects. Departmental researches have already (Y Abdulrazzaq) established that these drugs are teratogenic. It t
5IF
EFQBSUNFOU
JT
JOWPMWFE
JO
TUVEJFT
PO

54 Department of Paediatrics

micronutrients abnormalities in pregnancy and Vitamin D status from the birth to the effect on the fetus/newborn. The prelimi- adolescence (H Narchi, J Kochyil, R Zayed, M nary results suggest that micronutrient defi- Agarwal) ciency is common in pregnancy and outcome t
)ZQPWJUBNJOPTJT
XBT
GPVOE
JO

PG
QSFH- studies are in progress. nant women in Al Ain at their first antenatal booking, with progressive worsening towards t
5IF
EFQBSUNFOU
IBT
CFFO
BDUJWF
UISPVHI
UIF
delivery and up to 6 months postpartum. The years in experiments involving amino acids underlying mechanisms have been unraveled levels at different ages in the UAE popula- and recommendations have been made for tion and showed that some amino acids were prevention. abnormally high in newborn infants using the then available parenteral amino acid solution. t
)ZQPWJUBNJOPTJT
XBT
GPVOE
UP
CF
WFSZ
This led to a change in the solutions use in the common in otherwise healthy neonates and Medical District. has been shown to progressively improve over the first 6 months of life, without any vitamin D t
5IF
HSPVQ
XPSLJOH
PO
SFQSPEVDUJWF
UPYJDPMPHZ
supplementation. The mechanisms for this were has established that aflatoxin (a fungus toxin) studied. contamination of foods is very common, and that aflatoxins have been detected in blood of t
*O
WJFX
PG
UIF
IJHI
QSFWBMFODF
PG
IZQPWJUBNJ- pregnant women and their offspring in larger nosis D in young pregnant women, a popula- amounts than is acceptable. Measurement of tion based study on the status of Vitamin D aflatoxin in breast milk of lactating mothers is in levels among female adolescents is being progress. The results give a much clearer picture planned. These projects will provide informa- of exposure of infants to aflatoxins. tion which will lead to interventional studies in the future. The objective is to achieve normo- Neonatal periventricular leukomalacia- pvl vitaminosis D status in women prior to preg- (H Narchi, D Ghoneim, A Skinner) nancy. t
"
DPMMBCPSBUJWF
TUVEZ
XJUI
UIF
EFQBSUNFOU
PG
physics at the UAEU and neonatal units in UK Helicobacter Pylori (S Bharwani) hospitals has looked at the value of computer- t
1SFMJNJOBSZ
EBUB
TIPXT
UIBU
)
QZMPSJ
QSFWB- ised texture analysis of “flares” on neonatal lence is close to 60% in UAE. There is no data cranial ultrasound. We found this new technol- or cancer registry for gastric cancers in UAE and ogy to be highly predictive of lesions which will therefore the extent of H pylori involvement in eventually develop into PVL (with poor neu- Gastric cancer in this part of the world remains rodevelopmental prognosis) and those which elusive. We are in the process of creating gastric will resolve and which have a good outcome. cancer registry from the data in Al Ain and With this new technology the results are appar- Tawam hospitals. ent several weeks before changes can be seen on other imaging modalities. t
5IFSF
IBT
CFFO
B
TVSHF
JO
)
QZMPSJ
SFTJTUBODF
to the common antimicrobial agents like Perinatology (H Narchi, A Skinner) Clarithromycin and Metronidazole and in UAE t
"
DPMMBCPSBUJWF
TUVEZ
XJUI
6,
IPTQJUBMT
IBT
according to one study at least one out of three looked at the role of maternal overweight point mutations is present in 65% of infected and obesity on neonatal outcomes. Although individuals. This is an alarming trend and we are macrosomia was more prevalent and growth conducting a series of phenotypic and genotyp- retardation less common with increasing levels ic resistance studies to create new guidelines for of obesity, unlike previous reports, the results H pylori management in the UAE and likely GCC. have shown a lower prevalence of poor neona- The North American guidelines clearly will not tal outcomes. This is due to the multivariable hold grounds in this case. analysis model used and which has addressed the limitations of prior studies. The results are t
5IF
WJSVMFODF
GBDUPST
JO
)
QZMPSJ
$BH"
BOE
important for the management of obese preg- Vac A seem to be common in the middle east. nant women and their newborn. These virulent factors which have high likeli- hood of causing ulcers and newer biochemical

55 Department of Paediatrics

markers will help us in identifying susceptible bioenergetics (A K Souid, G Balhaj, F Al individuals whom we can treat with appropriate Jasmi) antibiotics. This personalized medicine is not t
5IF
SBUF
PG
MZNQIPDZUF
SFTQJSBUJPO
JT
EFUFS- only logical but is necessary to address the anti- mined for healthy adults, children and new- microbial resistance and rising healthcare costs. borns (umbilical cord blood). Lymphocytes from patients with presumed impaired respira- t
0VS
DPMMBCPSBUPST
BU
'.)4
IBWF
TIPXO
JO
tion are investigated. The aim of this project knock out animal models that the stem cells is to show feasibility of using the phosphores- may have a prominent role in the evolution- cence oxygen analyzer as a screening tool for ary transition of gastritis to Gastric cancer in patients with defective oxidative phosphoryla- certain H pylori infected individuals. This area tion. has certainly opened up possibilities for us to investigate in our Pediatric patients with H Haematology pylori infections that undergo endoscopies and t
3FE
DFMM
HMVUBUIJPOF
(4)
MFWFMT
JO
6"&
biopsies to study H pylori using immunehisto- patients with glucose-6-phosphate dehy- chemistry and electron microscopy. This study drogenase (G6PD) deficiency (A K Souid, F Al is already underway with collaborators from Al Jasmi). Blood samples will be collected from AIn Hospital, Tawam Hospital and the Depart- patients with G6PD deficiency during and after ment of Anatomy at FMHS acute hemolysis. The red blood cell thiols will be labeled with monobromobimane. The GS- Toxicology and pharmacology bimane derivatives will be separated on HPLC t
&òFDUT
PG
DZUPUPYJD
BHFOUT
PO
WBSJPVT
IV- and detected by fluorescence. man and animal tissues (A K Souid, G Balhaj, F Al Jasmi, M Al Samri, S Al Hammadi) Our t
&SZUISPDZUF
QIFOPUZQF
JO
&NJSBUJ
QFPQMF
primary interest is exploring toxin-induced with alpha-thalassemia trait. (A K Souid, S apoptosis, particularly the “mitochondrial cell Denic and S Showqi). death pathway”. Cell types include human lym- The aim of this project is to establish red blood phocytes and mouse hepatocytes, cardiomyo- cell reference values for UAE citizen. cytes and lungs. The toxins include aflatoxins B1, dactinomycin and doxorubicin. The princi- t
$PNQBSJTPO
PG
FSZUISPDZUF
JOEJDFT
UP
EJG- ple analytical method is a phosphorescence ox- ferentiate between iron deficiency and alpha ygen analyzer that measures cellular respiration thalassaemias in children with microcytosis (cellular mitochondrial oxygen consumption). and/or hypochromia (H Narchi, R Basak). Moreover, intracellular caspase activities are This study looked at the value of several RBC monitored on HPLC, using caspase substrates indices, calculated from available results on CBC such as Ac-DEVD-AMC and Ac-DEVD-AFC. of children with hypochromia and/or micro- cytosis, to predict alpha thalassaemia or iron t
6NCJMJDBM
DPSE
CMPPE
DFMM
UPYJDPMPHZ
"
deficiency, both being common conditions in K Souid, G Balhaj, S Al Hammadi and M Al children in the UAE. The results have impor- Samri) We investigate the effects of various tant clinical implications to avoid unnecessary toxic agents (e.g., aflatoxins B1) on circulating investigations and prevent inappropriate and fetal cells. potentially harmful administration of iron sup- plementation. t
$PODBOBWBMJO
"JOEVDFE
IFQBUJUJT
"
,
Souid, W Conca, A Shahin and M Lukic). We Allergy and immunology (S Al Hammadi) investigate whether Con A hepatitis is associ- t
"OBQIZMBYJT
UP
DBNFM
NJML has been report- ated with hepatocyte apoptosis. The animal ed and studied. models include wild-type (C57BL) and various t
5IF
prevalence of food allergy in children in knockout mice. The procedure requires isolated Al Ain has been established. hepatocytes. Apoptosis will be detect by meas- t
5IF prevalence and types of primary im- uring cellular respiration and caspase induction. munodeficiencies in the UAE is currently being studied. The use of oxygen analyzer to screen t
"
QSPKFDU
PO
atopic dermatitis and food sen- for disorders with impaired cellular sitization in children is being planned.

56 Department of Paediatrics

Respiratory medicine (M Al Samri) t
4FWFSBM
TUVEJFT
PG
VSPQBUIPHFOT
SFTJTUBODF
t
1FEJBUSJD
5SBDIFPTUPNZ
The aim of this to antibiotics in children with urinary tract project is to describe the natural history of pedi- infections (H Narchi, M Hamdani) have looked at atric tracheostomy and its outcomes. the role of first versus recurrent infection, pres- ence of vesicoureteric reflux and prior antibiotic t
4QVUVN
JOøBNNBUPSZ
QIFOPUZQF
JO
QB- prophylaxis. The results have implications for tients with asthma. The aim of this project is to clinical practice. describe inflammatory phenotypes in induced sputum in children with asthma. Airway in- flammation is a marker of asthma severity and Infectious diseases (S Uduman) response to treatment. t
$MJOJDBM
BOE
JNNVOPMPHJDBM
BTQFDUT
PG
IFQBUJ- tis C, seroepidemiology and neonatal screening Metabolic diseases( N Al Yasi , F Al Jasmi) of CMV and other congenital infections. t
4DSFFOJOH
GPS
'BCSZ
EJTFBTF
JO
EJBMZTJT
patients. The aim of this study to determine the Establishment of normal growth charts for prevalence of Fabry disease in UAE. children and the size at birth of infants born to uae nationals (Y Abdulrazzaq) Nephrology (H Narchi) t
5IFTF
HSPXUI
DIBSUT
IBWF
QSPWJEFE
UIF
t
"
TUVEZ
PG
CJPMPHJDBM
NBSLFST
PG
SFOBM
first standards for assessing intrauterine and tubular damage in young children with uri- postnatal physical growth of UAE newly born nary tract infections is underway (H Narchi, infants and children. Role of food allergy and M Hamdani, I Attrach, A Shibli, J Kochiyil, airway reactivity is another area of interest in G Dhatt) The association of the presence, our department. This is being investigated in a magnitude and duration of these markers as a population based approach. potential predictor for permanent renal cortical scarring will be looked into. The results might Cardiovascular (E Aburawi) potentially identify, without the risk of ion- t
*O
UIF
BSFBT
PG
%JBCFUFT
NFMMJUVT
BOE
DBSEJP- izing radiations, those children at higher risk vascular diseases the research activities in our of scarring who will need long0term antibiotic department is involved in the study of the prophylaxis and other uro-imaging studies. Cardiovascular Diseases Risk Factors in Emir- ates adolescents and young patients (age t
"O
FYQFSJNFOUBM
TUVEZ
PG
QSPUFJOVSJB
BOE
between 15 – 25 year-old) with type 1 and type urinary cytokines in mice with experimen- 2 Diabetes Mellitus. The hypothesis is to find out tal fever versus experimental nephrotic that the Microalbuminuria may correlate with syndrome (H Narchi, J Kochiyil) has shown a endothelial dysfunction and cardiovascular au- marked difference in the pattern of cytokines tonomic neuropathy in adolescents and young excretion. This would allow differentiation adults. Young patients with T1DM and T2DM between the benign proteinuria associated with that carry the high risk Haptoglobin 2 allele febrile illnesses in nephrotic children, versus the would have higher levels of oxidative stress and onset of a relapse of nephritic syndrome where more diabetes complications. prolonged corticosteroid therapy would be required, with potential requirement for renal t
&òFDUT
PG
/
1PMZVOTBUVSBUFE
'BUUZ
"DJET
biopsy and cytotoxic or immunosupooressive (PUFAs) on Left Ventricular Function and therapy. Coronary Flow (CF) in Children with Type 1 Diabetes Mellitus. Young diabetics are at risk of t
"O
FYUFOTJPO
PG
UIJT
TUVEZ
PO
OFQISPUJD
DIJM- developing diabetic cardiomyopathy. Coronary dren is being planned flow disturbance is suggestive of coronary microvascular dysfunction, which is the earliest t
"
TUVEZ
PG
GPFUBM
IZESPOFQISPTJT has shown manifestation of coronary heart disease (CHD). that, when diagnosed in the third trimester of The interaction between inflammation and the pregnancy, it has a higher predictive power for adaptive immune system are the mechanistic underlying uropathies. These results will result link for the pathogenesis of Type 1 DM and its in modifications of current guidelines. complications. Coronary flow disturbance could

57 Department of Paediatrics

be secondary to inflammation and endothe- objectives, has identified which objectives lial dysfunction. Improvement of endothelial are duplicated and which are unique to each dysfunction would favourably influence the examination. This will allow proper alignment of clinical prognosis. PUFAs reduce the inflamma- our assessment methods with our educational tory processes, vasoconstriction, and platelets objectives set out in our paediatric curriculum. aggregation, all known to be antiatherogenic. (H Narchi) This is a collaborative study with Lund Univer- sity, Sweden. t
4UVEFOUT
BOE
GBDVMUZ
QFSDFQUJPOT
BCPVU
the individual faculty evaluation – Survey (E t
$PSPOBSZ
øPX
JO
CBCJFT
XJUI
*OUSB6UFSJOF
Aburawi, S Shaban, M Mc Lean) Growth Retardation. Subclinical myocardial injury has been reported in newborns with fetal weight below 2 standard deviations for the ges- tational age. Our aim was to investigate whether impaired intrauterine growth affects cardiac function and coronary flow. This is a collabora- tive study with Lund University, Sweden.

t
4UVEZ
PG
NZPDBSEJBM
GVODUJPO
DPSPOBSZ
øPX
and inflammatory markers before and after cardiac surgery with Heart Lung Machine. How to prevent the myocardial injuries? An animal study. This is a collaborative study with Lund University, Sweden.

t
8F
BSF
DBSSZJOH
PVU
B
/BUJPOBM
4VSWFZ
JO
patients with Down and its associated prob- lems. The aims are to assess the prevalence of overweight/obesity and to establish the references for body mass index (BMI) percentile curves for Emirates children with uncomplicated Down syndrome. We are looking at the mark- ers of Alzheimer Disease in these children. Also, we will study the epidemiology of CHD in these children. We are planning to carry out analysis of peripheral blood T-cell subsets, Natural killer cells and serum levels of cytokines in these Emirates children with Down syndrome.

Medical education (H Narchi) t
4UVEZ
PG
UIF
QSFEJDUJWF
WBMVF
PG
UIF
QBF- diatric in-house examination at the end of clerkship with regard to the NBME examina- tion has identified the key components of our examination which can predict the NBME marks. These results, when used as a formative assess- ment, will help identify students predicted not to perform well at the NBME and offer remedial action. (H Narchi)

t
$PNQBSJTPO
PG
UIF
FEVDBUJPOBM
PCKFDUJWFT
of the paediatric in-house examination at the end of clerkship and of the NBME examina- tion, using Bloom’s taxonomy of educational

58 Department of Paediatrics

Salam S, Marzouqi F, Al Mansouri Guan Z, Silhavy JL, Bielas SL, Lehle Articles in Peer- A, Al-Hammadi S, Balhaj G, Al Da- L, Hombauer H, MAdamowicz, reviewed Journals waar SK, Al Hanjeri RS, Benedict S, Swiezewska E, De Brouwer AP, Sudhadevi M, Conca W, Penefsky Blümel P, Cegielska J, Houliston Aburawi EH. (2010). Pesonen E. HS, Souid AK. (2010). Measure- SR, Swistun D, Ali BR, Babovic- Pathophysiology of coronary ment of oxygen consumption by Vuksanovic D, van Bokhoven H, blood flow in congenital heart murine tissues in vitro. J Pharma- Wevers RA, . Raetz CRH, Freeze, disease. Int J Cardiol. [Epub ahead col Toxicol Methods. [Epub ahead HH; Morava E, Al-Gazali L, Gleeson of print]. of print] JG. (2010). The SRD5A3 gene is required for the conversion of Aburawi EH. (2010). Elkhammas Al Shamsi M, Al Samri MT, Al- polyprenol to dolichol, essential E. International Classification of Salam S, Conca W, Shaban S, Ben- for N-linked protein glycosylation. Diseases: A Call for Adaptation in edict S, Tariq S, Biradar A, Penefsky Cell; 142:203-217. Developing Countries. Editorial. HS, Asefa T, Souid A-K. (2010). Ibnosina J Med BS.; 2 (2):51-52. Biocompatibility of calcined De Carvalho PP, Thornton G, Herte- mesoporous silica particles with cant J, Houlden H, Nicholas AK, Aburawi EH. (2010). Medical Ethics cellular bioenergetics in murine Cox J, Reilly M, Al-Gazali L, Woods in the Developing World: Time to tissues. Chemical Research in CG. (2010). A novel NGF mutation Strengthen the Rules. View point. Toxicology;23:1796-1805. clarifies the molecular mechanism Ibnosina J Med BS.;2 (3):103-104. and extends the phenotypic spec- Alsuwaidi AR, Wiebe D, Burdz trum of the HSAN5 neuropathy. J Ali BR, Xu H, Akawi NA, John A, T, Betty Ng, Reimer A, Singh C, Med Genet; (Epub ahead of print). Karuvantevida NS, Langer R, Al- Bernard K. (2010). Corynebacte- Gazali L, Leitinger B. (2010). Traf- rium macginleyi Conjunctivitis in Iannicelli M, Brancati F, Mougou- ficking defects and loss of ligand Canada. Journal of Clinical Micro- Zerelli S, Mazzotta A, Thomas S, binding are the underlying causes biology. 48: 3788-3790. Elkhartoufi N, Travaglini L, Gomes of all reported DDR2 missense mu- C, Ardissino GL, Bertini E, Bolt- tations found in SMED-SL patients. Bharwani S, Basak R, Khan Q. shauser E, Castorina P, D’Arrigo S, Hum Mol. Genet. ;19(11):2239-50. (2010). Rotavirus induced Systemic Fischetto R, Leroy B, Loget P, Bon- Inflammatory Reaction Syndrome nière M, Starck L, Tantau J, Gentilin Ali BR, Akawi NA, Chadid F, Bakir (SIRS) in an infant. J Pediatr Gastro- B, Majore S, Swistun D, Flori E, M, Rehman MU, Rahmani A, Al- enterol Nutr. ;1(2):E 13(1-115) Lalatta F, Pantaleoni C, Penzien J, Gazali L. (2010). Molecular and Grammatico P; Novel TMEM67 mu- clinical analysis of Ellis- van- Crev- Bharwani S, Bharwani SS, Kamal A, tations and genotype-phenotype eld syndrome in the UAE. BMC Shah M, Rahim M. (2010). Higher correlates in meckelin-related cili- Med.Genet;11(1):33. rates of H pylori reinfection in opathies. International JSRD Study children is likely due to the gender Group, Dallapiccola B, Gleeson JG, Al-Gazali L, Ali BR. (2010). Muta- specific health care seeking Attie-Bitach T, Valente EM (2010). tions of a Country: a mutation behavior of their parents. J Pediatr Hum Mutat.;31(5):1319-31. review of single gene disorders in Gastroenterol Nutr ; 51(2):E 47(1- the UAE. Hum Mutat.;31(5):505-20. 115) Kate LP, Al-Gazali L, Anand S, Bit- tles A, Cassiman J-J, Christianson Al-Hammadi S, El-Hassan T, Al- Bharwani S, Basak R, Khan Q. A, Martina C Cornel, Hamamy H, Reyami L. (2010). Anaphylaxis to (2010). Protein Losing Enteropathy Kääriäinen H, Kristoffersson U, Ma- camel milk in an Atopic Child. (PLE) associated with Rotavirus in rais D, Penchaszadeh VB, Rahman Allergy; 65(12):1623-25. an infant. Journal of Gastroenter- P, Schmidtke J. (2010). Community ology & Hepatology; 25(2): A24 Genetics. Its definition 2010. J Al-Hammadi S, Al-Maskari F, (23-78) Comm.Genet.;1:19-22. Bernsen R. (2010). Prevalence of Food Allergy among Children in Beckdache G, Begum M, Al-Gazali Matejas V, Hinkes B, Al-Gazali Al-Ain City, United Arab Emirates. L, Ali BR, Akawi N, Merghani H. L, Alkhandri F, Atac MB, Barrow Int Arch Allergy Immunol; 151(4): (2010). Case Report: Prenatal diag- M, Blahova K, Bockenhauer D, 336-342. nosis of thanatophoric dysplasia Cheong HI, Chudek IM, Cochat P, and obstetrical challenges. J Obst Dotsch J, Hennekam RC, Kagan M, Al-Jasmi F, Moldovan L, Clarke JT. & Gyn.;30:626-630. Kariminejad A, Kemper MJ, Koenig (2010). Hunter disease eClinic: J, Kogan J, Kroes HY, Kuwertz- interactive, computer-assisted, Bastaki SM, Osman N, Kochiyil J, Broking E, Lewanda A, Medeira A, problem-based approach to Padmanabhan R, Abdulrazzaq YM. Muscheites J, Niaudet P, Pierson M, independent learning about a (2010). Toxicogenetics of Aflatoxin Saggar A, Seaver L, Suri M, Tsygin rare genetic disease. BMC Med in pregnant mice. Int J Toxicol. A, Urban M, Wuhl E, Zurowska A, Educ.10; 72 9(4):425-31. Hildebrandt F, Zenker M (2010). Mutations in human Laminin β2 Al Samri MT, Al Shamsi M, Al- Cantagrel, V, Lefeber DJ, BG. Ng, (LAMB2) gene and the associated

59 Department of Paediatrics

phenotypic spectrum. Hum Mu- tal Hydronephrosis and Urinary Al-Gazali L, Fujita T, Seki G. (2010). tat.; (9):992-1002., [Epub June 15] Tract Anomalies: Third Trimester Defective membrane expression Versus 20-week Scan. Journal of of Na –HCO3 – cotransporter Mochida GH, Ganesh V, Felie J, Pediatric Sciences.;2(2):e34, 2-9. NBC1 is associated with familial Gleason D, Hill Rs, Clapham KR, migraine. Proc Natl Acad Sci USA; Rakiec D, Tan W, Akawi N, Al-Saffar Narchi H, Al Marah M .(2010). 107(36):15963-15968. M, Partlow JN, Tinschert S, Barko- Uropathogen resistance to oral vich J, Ali BR, Al-Gazali L, Walsh CA. antibiotic prophylaxis in urinary Tukul T, Sosic D, Al-Gazali L, Erazo (2010). A homozygous mutation tract infections. Microb Drug M, Casasnovas J, Franco HL, Olson in the tight junction protein JAM3 Resist.;16(2):151-4. EN, Cadilla CL, Desnick RJ. (2010). causes hemorrhagic distruction of Homozygous nonsense mutations the brain, subependymal calcifica- Narchi H, Skinner A. (2010). Over- in TWIST2 cause Setleis syndrome. tion and congenital cataract. Am J weight and obesity in pregnancy Am J Hum Genet.;87:289-296. Hum Genet.(Epub ahead of print) do not adversely affect neonatal outcomes- New evidence. J Ob- Whyte DA, Al-Hammadi S, Balhaj Morava E, Wevers RA, Cantagrel stet Gynaecol. ;30(7): 679–686. G, Brown OM, Penefsky HS, Souid V, Hoefsloot LH, Al-Gazali L, A-K. (2010). Cannabinoids inhibit Schoots J, de Rooi Aj, Huyben Narchi H, Skinner A. (2010). Infants cellular respiration of human oral K, van Ravenswaaij-Arts CMA, of diabetic mothers with abnormal cancer cells. Pharmacology; Jongmans MCJ, Sykut-Cegielska J, fetal growth missed by standard 85:328-335. Babovic-Vuksanovic D, Hoffmann growth charts. J Obstet Gynaecol.; G, Bluemel P, Adamowicz M, van 30(7): 764–765. Reeuwijk J, Freeze HH, Berg- k man J, van Bokhoven H, Körner Ostanin DV, Brown CM, Gray L, C,Lehle L, Gleeson JG, Willemsen Bharwani S, Grisham MB. (2010). MA, de Brouwer APM, Lefeber Evaluation of the immunoregu- Published DJ (2010). A novel cerebello- latory activity of intraepithelial ocular syndrome with abnormal lymphocytes in a mouse model of Abstracts, glycosylation due to abnormalities chronic intestinal inflammation. Letters and in dolichol lipid metabolism. Brain Int Immunol.; 22(12):927-39. 2010;133(11):3210-3220( Epub). Correspondence Padmanabhan R, Abdulrazzaq YM, Narchi H, Skinner A, Williams B. Bastaki SMA, Nurulain M, Shafiul- Al-Gazali L. (2010). Genetic (2010). Small for gestational age lah M. (2010). Vigabatrin (VGB) disorders in the UAE: magnitude neonates- are we missing some by administered during late gestation and prevention strategies. Global only using standard population lowers maternal folate concentra- health and the UAE: Asia-middle growth standards and does it mat- tion and causes pregnancy loss, fe- East Connections. Al-Ain, UAE. ter? J Matern Fetal Neonatal Med. tal growth restriction and skeletal 2010; 23(1):48-54. hypolpasia in the mouse. Repro- Al-Hammadi S, El-Hassan T, Al- ductive Toxicology. 29:366-377. Reyami L. (2010). Anaphylaxis to Narchi H, Al Marah M .(2010). Camel Milk. Allergy;65(s92). Antibiotic resistance trends in Shaban S, Marzouqi F, Mansouri paediatric community-acquired A, Penefsky HS, Souid A-K. (2010). Al Jasmi F. (2010). A Novel Muta- first urinary tract infections in the Oxygen measurements via tion in atypical presentation of a United Arab Emirates. East Med phosphorescence (2010). Com- rare infantile Farber disease. 10th Health J.; 16(1): 45-50. puter Methods and Programs in IWLSD. Prague, Czech Republic Biomedicine;100: 265-268. Narchi H, Basak BR. (2010). Com- Al Jasmi F. (2010). Mild Clinical parison of erythrocyte indices to Souid AK, Dubowy RL, Ingle AM, Phenotype of Mucolipidosis type differentiate between iron defi- Conlon MG, Sun J, Blaney SM, III. 11th International Symposium ciency and alpha thalassaemias in Adamson PC. (2010). A pediatric on Mucopolysaccharide and children with microcytosis and/ Phase I trial and pharmacoki- related diseases. Adelaide, South or hypochromia . East Med Heath netic study of ispinesib: A Children Australia J.;16(9): 966-971. Oncology Group Phase I Consor- tium Study. Pediatric Blood and Ali BR, Xu H.-F, Akawi NA, John A, Narchi H, Kochiyil J, Zayed R, Cancer;55:1323-1328. Karuvantevida NS, Langer R, Al- Abdulrazzak W, Agarwal M. Gazali L, Leitinger B. (2010). Traf- (2010). Maternal vitamin D status Suzuki M, Paesschen WV, Stalmans ficking defects and loss of ligand throughout and after pregnancy - I, Hprita S, Yamada H, Bergmans binding are the underlying causes a longitudinal prospective study.J BA, Legius E, Riant F, De Jonghe P, of all reported DDR2 missense Obstet Gynaecol ; 30(2): 137–142. Li Y, Sekine T, Igarashi T, Fuji- mutations found in Spondylo- moto I, Mikoshiba K, Shimadzu meta-epiphyseal dysplasia with Narchi H, Donovan R. (2010). Foe- M, Shiiohara M, Braverman N, short limbs and abnormal calcifi- cations [SMED-SL] patients. British

60 Department of Paediatrics

Society for Matrix Biology Meeting Mahboub B, Pawankar R, Rafique ogy of Fallot by Transthoracic on: ‹Vascular Matrix in Health & M, Sulaiman N, Al-Hammadi S, Ib- Doppler echocardiography. 15th Disease.’ Manchester, UK, rahim A. (2010). Prevalence, treat- World Congress on Heart Disease, ment patterns and risk factors of Vancouver, Canada. Ali BR, Hertecant J, Al-Jasmi F, asthma and rhinitis among adults Hamdan MA, Akawi NA, Al-Gazali in the UAE. WAO international Aburawi E. (2010). Interventional L. (2010). Mutational analysis of scientific conference. Asthma and Catheterization in Congenital a spectrum of inborn errors of co-morbid conditions: Expanding Heart Disease. Rotana Hotel, metabolism disorders from the the practice of allergy for optimal Al-Ain. United Arab Emirates. 3rd Pan patient care, December 2010, Arab Genetics Conference, “Ge- Dubai, UAE Aburawi EH, Erkki Pesonen (2010). nomics Healthcare,” Dubai, UAE. Pathophysiology of coronary Movrava E, de Brouwer APM, blood flow in congenital heart Ali BR, Akawi NA, John A, Al-Gazali Wevers RA, Cantagrel V, Jongmans disease. 15th World Congress on L. (2010). Cellular Organelle Dis- MCJ, van Ravenswaaiji-Arts D, Ng Heart Disease, Vancouver, Canada. ease Genomics: the ER-Associated B, van D, van Bokhoven, Babovic- Protein Degradation (ERAD) is a Vuksanovic D, Gleeson JG, Lefeber Al Hammadi S. (2010). Anaphy- Major Mechanism Underlying Nu- D, AL-Gazali L. (2010). A novel laxis to Camel milk. EACCI 2010, merous Human Genetic Disorders. cerbello-ocular syndrome with London, UK. 3rd Pan Arab Genetics Conference, abnormal glycosylation due to “Genomics Healthcare,” Dubai, abnormalities in dolichol metabo- Al Hammadi S. (2010). Primary UAE. lism. ASHG, Washington, USA. Immunodeficiency Disorders in United Arab Emirates. The 1st Ali BR, Xu H, Akawi NA, John Padmanabhan R, Bastaki SM, Symposium of Prince Naif Center A, Karuvantevida NS, Langer R, Abdulrazzaq YM. (2010). Develop- for Immunology Research and 2nd Leitinger B, Al-Gazali L. (2010). The ment toxicity of topiramate in the Asthma Research Chair meet- cellular and biochemical mecha- mouse. The Journal of Maternal- ing (PNCIR 2010). Riyadh, Saudi nisms underlying Sponydylo-me- Fetal & Neonatal Medicine 2010; Arabia. ta-epiphyseal dysplasia with short 23 (1):173. limbs and abnormal calcifications Al Hammadi S. (2010). Genetics of (SMED-SL). 3rd Pan Arab Genetics Allergic Diseases – Selected Topics. Conference, “Genomics Health- k Advances in Pediatric Allergy and care,” Dubai, UAE Asthma. Kuwait city, Kuwait. Bharwani S, Bharwani SS, Kamal A, Proceedings, Al Jasmi F. (2010). Biotinidase De- Shah M, Rahim M. (2010). Gender ficiency &Galactosemia. Presented Differences In Healthcare Seeking Conferences, at Newborn Screening. Abu-Dhabi Behaviour May Adversely Affect Invited Lectures, Health Authority, UAE H Pylori Eradication Efforts. Gut 2010;(vol 59)Suppl III, A169 Web Sites Al Jasmi F. (2010). Mild phenotype of mucolipidosis III. Presented at Bharwani S, Bharwani SS, Kamal and Others 3rd Pan Arab Human Genetics A, Shah M. (2010). Management Abdulrazzaq YM. (2010). Hearing Conference, Dubai. UAE Practices of H pylori infection in a screening of the newborn. The tertiary center in the United Arab Launch Event of Newborn Screen- Al Jasmi F. (2010). Premarital Emirates (UAE). Journal of Gastro- ing Program in Emirates of Abu genetic Counseling and prenatal enterology & Hepatology;25(2): Dhabi . Abu Dhabi, UAE. diagnosis of inherited Metabolic A158 (79-158) disorders. 8th International Pediat- Abdulrazzaq YM. (2010). Update ric Conference, Benghazi Medical Huber C, Rossi A, Merina R, Fradin on NO use in the newborn, 3rd Center, Benghazi. Libya M, Abdulibdeh B, Alanay Y, Albre- International Conference, Neo- cht B, Al-Gazali L, Ausems MGEM, natal Society, Emirates Medical Al Jasmif F. (2010). Hyperam- Bitoun P, Cavalcanti D, Hudson J, Association. monemia: approach and emer- Krebs A, Le Merrer M, MacKay S, gency treatment. 8th International Mortier G, Morton J, Robertson SP, Abdulrazzaq YM. (2010). Devel- Pediatric Conference, Benghazi Sillence D, Shafeghati Y, Superti- opmental toxicity of topiramate Medical Center, Benghazi. Libya Furga A, Muda AO, Zerres K, Mun- in the mouse. XXII European Con- nich A, Le Goff C, Cormier-Daire V. gress Perinatal Medicine, Granada, Al Jasmif F. (2010). Mucopolysac- (2010). CANT1 does not account Spain. charidosis type I. MPS meeting for all Desbuauois dysplasia cases Children Hospital, Tehran, Iran. but is directly involved in prote- Aburawi EH, Erkki Pesonen. oglycan synthesis. ASHG, Wash- (2010). Coronary flow dynamics Al Jasmi F. (2010). Practical man- ington. in children after repair of Tetrol- agement of positive newborn

61 Department of Paediatrics

screening test. Newborn screening an infant. Asian Pacific Digestive Coronary flow in babies with meeting, Dubai. UAE Week (APDW) 2010, Kuala Lumpur, Intra-uterine Growth Retardation. Malaysia. 2010 - 2011 Al Jasmi F. (2010) Unknown case. 7th Middle East Metabolic Group Bharwani S. (2010). Management Dr. S Bharwani [PI) Meeting, Bahrain Practices of H pylori infection in a UAE University SEED Grant to look tertiary center in the United Arab at the Helicobacter pylori infection Al Jasmi F. (2010). Lysosomal Stor- Emirates (UAE). Asian Pacific Di- trends in UAE, 2009-2012 age disease in UAE. Middle Eastern gestive Week (APDW) 2010, Kuala Lysosomal Storage Disease Expert, Lumpur, Malaysia. Prague, Czech Republic UAEU Individual Grant Narchi H. (2010). Neonatal issues Al Jasmi F. (2010). Raising aware- in Primary Care. 3rd Middle East Drs E Aburawi (PI), J Al Kaabi, A ness of LSDs in the Middle Review Course in Primary Health Shehab. East-present and future initiatives. Care Conference. Abu Dhabi Cardiovascular Diseases Risk Fac- Middle Eastern Lysosomal Storage tors in UAE adolescents and young Disease Expert, Prague, Czech Narchi H. (2010). Undergraduate adults with type 1 and type 2 Republic Paediatric Education- Predictive Diabetes Mellitus. validity of an in-house summative Bharwani S. (2010). Infant Mortal- examination with regard to the Drs. Hassib Narchi (PI), D Ghome- ity and the first 90 seconds after National Board for Medical Exam- im, A Skinner, P Coggins. birth. Midwife Community Pro- iners (NBME) examination for in- Texture analysis of white matter gram, Funded by USAID, Bada- ternational students. International flaring areas on neonatal cranial khshan, Afghanistan. Conference in Medical Education. ultrasound scans. Abu Dhabi. Bharwani S. (2010). Ignoring the Dr S Al-Hamadi elephant in the room-Is it time for Narchi H. (2010).Undergraduate Atopic Dermatitis in Children: GCC guidelines in managing H Paediatric Education- The use of Importance of Food sensitization. pylori related illnesses in children? Bloom’s taxonomy of educational 2nd Pediatric gastroenterology objectives to compare the content UAE University Interdisciplinary GCC Forum-Dubai. validity of an in-house summa- Grant tive examination and the Na- Bharwani S. (2010). Gender Dif- tional Board for Medical Examiners Professor L Al-Gazali (PI) ferences In Healthcare Seeking (NBME) subject examination for in- Homozygosity mapping and Behaviour May Adversely Affect H ternational students. International molecular characterization of Pylori Eradication Efforts. United Conference in Medical Education. recessive disorders in the UAE. European Gastroenterology Week Abu Dhabi. (UEGW) 18th Annual meeting, National Research Foundation Barcelona, Spain. Pesonen E, Aburawi E. (2010). Grant Pathophysiology of Coronary Bharwani S. (2010). Rotavirus Blood Flow with reference to Professor L Al-Gazali (Co-PI ) induced Systemic Inflammatory Congenital Heart Diseases. Oral Manipulation of endoplasmic Reaction Syndrome (SIRS) in an presentation at 15th World Con- reticulum protein degradation infant. North American Society gress on Heart Disease conference machinery for therapy of genetic of Gastroenterology, Hepatology of Cardiology, Shanghai, China. diseases. and nutrition (NASPGHAN) Annual Meeting & Postgraduate Course Sheikh Hamdan Award for 2010, New Orleans, USA. k Medical Sciences Bharwani S. (2010). Higher Rates Dr. E Aburawi (PI), Drs J Al Kaabi, A Of H Pylori Reinfection In Chil- RESEARCH GRANTS Shehab, B Ali, Prof H Al Saadi dren Is Likely Due To The Gender Cardiovascular Diseases Risk Fac- Specific Health Care Seeking FMHS Research Grants tors in UAE adolescents and young Behavior Of Their Parents. North adults with type 1 and type 2 American Society of Gastroenter- Drs H Narchi (PI), L Al Reyami, N Al Diabetes Mellitus ology, Hepatology and nutrition Hassani, G Ghatasheh. (NASPGHAN) Annual Meeting & Why do some parents refuse di- Prof YM Abdulrazzaq Postgraduate Course 2010, New agnostic lumbar puncture on their Reproductive toxicological effect Orleans, USA. child despite medical advice? of lamotrigine on mice.

Bharwani S. (2010). SIRS and Seed Grant Emirates Foundation Grant Protein Loosing Enteropathy (PLE) associated with Rotavirus in Dr. E Aburawi (PI) Dr EH. Aburawi, (PI) Profs YM Ab-

62 Department of Paediatrics

dulrazzaq, N Nagelkerke. Others National Survey of children with Down syndrome and its associ- Professor L Al-Gazali (PI ) ated problems. A startup funding for a “Center of Excellence in Genetics Research” Drs H Narchi (PI), G Dhatt, M Al at UAEU. UAE University and Hamdani, Attrach. National Research Foundation Tubular cells damage markers in Initiative 2010/11 (AED250,000). the urine of children with urinary Identification of Disease Genes of tract infection and correlation Recessive Disorders Prevalent in with permanent renal scarring. UAE.

Prof YM Abdulrazzaq Study of the impact of aflatoxins k on cellular respiration and caspase activation. Duration- 2years.

2010Paediatrics

Standing left to right: Dr F Al-Jasmi, Dr S Benedict, Ms Sania Al Hamad , MS R Clemente, Mr J Kochiyil, Mr M Jamal, Mr Pramathan T. Seated left to right: S Bharwani, Dr S Al Hammadi, Prof L Al-Gazali, Dr M Al Samri, Dr H Narchi, Dr E Aburawi, Dr A Al Suwaidi.

http://www.fmhs.uaeu.ac.ae/Departments/Paediatrics Tel: 7672000 / Fax: 7672067

63 Department of Pathology

Research Profile:

Professor & Chair: Pathology is a wide-ranging discipline of Prof M Agarwal laboratory medicine. It covers several fields, Associate Professor: Dr A Castella including histopathology, cytology, laboratory Dr B Ali hematology, clinical chemistry, genetics and Dr S Al Salam molecular biology. Assistant Professor: Dr A Al Bawardi Dr S Almarzooqi Medical Research Clinical Chemistry: (Prof Mukesh M. Agarwal) Specialist: In the UAE, the prevalence of diabetes mellitus (DM) is the sec- Ms A J Mathew ond highest in the world. This remains a major epidemiological Ms M Sudhadevi challenge for the country. Multiple studies agree that aggressive Medical Secretary: life-style changes (after delivery) in women with gestational Ms K Al Ghanem diabetes mellitus (GDM) can delay and even prevent the onset Office Assistant: of Type 2 DM. Much of our research efforts are directed to GDM: Mr M Hashiq How to screen a large population in a cost-effective manner? We are studying the value of various simple screening tests for GDM, which have a high degree of sensitivity. Ultimately, not missing any pregnant woman with GDM will help us to start prevention for DM, after childbirth. This will help our ultimate objective: to decrease the epidemic of Type 2 DM in the UAE.

Hematopathology: (Dr Antonio Castella) Lymphomas are malignant monoclonal disorders of the lym- phatic system, which show diverse clinical features, pathology and outcome. The pathological classifications are controversial, especially with regard to non-Hodgkin’s lymphomas (NHL). In recent years, new classifications have been proposed which are based on modern concepts of lymphocyte function. The latest classifications of lymphomas (REAL) and (WHO) are an attempt to resolve the lack of uniformity in the reporting of malignant lym- phomas by defining the different types according to morphology and immunology as well as cytogenetics.

Although lymphomas show a worldwide distribution, geographi- cal variations in their histopathologic pattern, especially NHL, are well recognized. However, in the Middle East, and specifically in the Gulf countries, there was a paucity of data concerning the patterns of histopathologic subtypes of lymphomas.

64 Department of Pathology

The Pathology department undertook a project, The Molecular and Cellular Basis of Genetic in collaboration with Tawam and Al Ain Hospitals, Diseases: (Dr Bassam R. Ali) to study the pattern of lymphomas in the UAE. Current Research Focus: 1. Identification of the molecular defects un- The aim of this study was to analyze the dis- derlying single gene disorders in the UAE and tribution of the various pathologic types of Arab populations. Recessive disorders are highly lymphoma in a native Arab population of the prevalent in Arab populations including UAE UAE. More than 200 native patients with lym- mainly due to high levels of consanguinity and phoma were studied. The cases were examined lack of prenatal and/or pre-conception diag- morphologically and immunohistochemically nosis. We are developing a molecular genetics with an extensive panel of monoclonal antibod- research laboratory to look at the molecular de- ies, and are classified according to the revised fects causing recessive disorders found in UAE European-American classification of lymphoid population with emphasis on mental retarda- neoplasms (REAL). The results were compared tion phenotypes, metabolic and dysmorpholo- with the distribution of lymphomas in other gy disorders. We are collaborating with major re- Asian and Western countries. search groups at Harvard Medical School (USA), University of California in San Diego USA), King In addition, a second project studied the dif- Faisal specialist Hospital and Research Center ferences of the distribution pattern of NHL (KSA) and Sultan Qaboos University (Oman). between native UAE cases and a similar number of cases diagnosed in expatriates living in the

Figure: Left side, classic binucleated Reed- Sternberg cell in a case of Hodgkin’s disease (arrow) (H & E x 40), right side, immunohistochemistry with CD30 antibodies highlights the Reed- Sternberg cells (dark brown color).

UAE. No differences are found between the two 2. The cellular mechanisms of human mono- population groups suggesting that environ- genic disorders. We are interested in protein mental factors may play a role in the developing trafficking and quality control within eukaryotic of NHL in the UAE. cells. The protein quality control at the endo- plasmic reticulum level is responsible for the The results of some of this work have already development of several human genetic diseases been published in peer-reviewed journals and including cystic fibrosis and emphysema. We presented in International Pathology and Oncol- have recently elucidated the cellular mecha- ogy conferences. nisms underlying Robinow syndrome and Acromesomelic Dysplasia type Maroteaux and The expression of EBV in Hodgkin lymphoma SMED-SL, recessive disorders that have been among UAE nationals was studied in collabora- found in several parts of the Middle East includ- tion with Dr. Suhail Al-Salam (PI), by immunohis- ing Oman and Saudi Arabia. We are currently tochemistry for the latent membrane protein- I looking to establish the mechanisms underlying and in situ hybridization for EBV encoded RNA Familial Hypercholesterolemia, Hereditary Hem- (EBER). EBV was seen in 17 of 45 (38%) cases orrhagic Telangiectasia and other ER-associate of HL and was predominately seen in the MC degradation diseases. In addition, we are explor- subtype followed by NS, LD and LR subtypes, ing ways of manipulation ER quality control for respectively. (Figure) potential therapy of such diseases.

65 Department of Pathology

Histopathology/ lymphoma/ Breast estrogen receptors and progesterone pathology / CNS pathology/Renal Pathology/ receptors expression. Molecular Pathology (Dr. Suhail Al-Salam) Breast carcinoma is the most common malig- nant tumor and the leading cause of cancer 1. Expression of EBV in Hodgkin Lymphoma death in women all over the world. It is the among UAE nationals. commonest cancer among UAE population and The epidemiology of Hodgkin’s lymphoma (HL) the most common cancer among females .The shows wide geographic variation in histological age specific incidence ratio for females in UAE subtypes and in its association with the Epstein- was 19.4 per 100,000 population. It is currently Barr virus (EBV). The proportion of EBV positive estimated that 5–10% of all breast cancers are HL is low in industrialized countries, high in hereditary and attributable to mutations in non-industrialized countries and intermediate several high penetrance susceptibility genes, of in early-industrialized countries. Reports from which only two have been identified BRCA1 and the Arabian Gulf and Middle East are few. The BRCA.2. Earlier estimates suggested that BRCA1 aim of our study was to determine the epide- and BRCA2 mutations were responsible for 75% miology of HL in The population of United Arab of site-specific breast cancer families and the

Figure: Figure: (A) Hodgkin lymphoma with classical Reed–Sternberg cell showing dark-purple nuclear staining for EBER, in situ hybridization, X400. (B) Classical Reed–Sternberg cell showing membranous, cytoplasmic and Golgi immunoreactivity to LMP-1, streptavidin–biotin, X400

Emirates (UAE) nationals, an early industrialized majority of breast and ovarian cancer families. country in the Arabian Gulf, and to delineate The aim of this study is to identify the types of the extent of its association with EBV. We review mutations in BRCA 1 and BRCA 2 genes in breast the cases of HL for the period 1988 through carcinoma among United Arab Emirates nation- 2004 for histological classification and demo- als and their correlation with the expression graphic data. All Cases diagnosed as Hodgkin’s P53,Ki 67,bcl2,nm2, c-erb-B2, estrogen receptors lymphoma were examined for the presence of and progesterone receptors. EBV using immunohistochemistry (IHC) for the latent membrane protein I (LMPI) and in-situ 3. Role of Trefoil Factor Peptides in the hybridization (ISH) for EBV encoded RNA (EBER) Development and Progression of Glioma. to determine the prevalence of EBV in Hodgkin Gliomas are the most common primary central cells and its possible role in the pathogenesis of nervous system tumors. They are the second Hodgkin’s lymphoma. EBV was seen in 17 of 45 most common cancer among children in UAE. (38%) cases of HL and was predominately seen They are graded into four grades from grade 1 in the MC subtype followed by NS, LD and LR which is the most benign to grade 4 which is the subtypes, respectively. (Figure) most malignant. They are characterized by pro- gression from low grade to high grade within 2. Types of mutations in BRCA 1 and BRCA the same tumor. This progression is not well 2 genes in breast carcinoma among United understood. Furthermore, the pathogenesis of Arab Emirates nationals and their correlation glioma is obscure. Several studies have shown with P53, Ki 67, bcl2, nm2, c-erb-B2, the transforming potential of TFF peptides

66 Department of Pathology

which is illustrated in tissues involved in cancer sis in breast carcinoma using archive paraffin progression, while other studies have shown blocks of breast carcinomas in the pathology tumor suppressor action of TFF peptides. How department at Tawam Hospital in Al Ain. We will can the apparent contradiction between the use the streptavidin-biotin immunohistochemi- tumor-promoting and tumor-suppressing func- cal staining method, in studying the expression tions of TFF peptides be resolved? We hope that of different markers that are essential for achiev- this project will answer some of these queries. ing our goals in this project. There are nearly no published data concerning the expression of TFFs in human gliomas. In We expect that our suggested study will clarify addition there was no previous reports concern- and elucidate the role of HIF-1 α as possible ing the role of trefoil factors in the pathogenesis predictors of lymph node metastasis in breast or progression of glioma. Our preliminary study carcinoma and will provide new achievements on few cases of gliomas using immunohisto- in understanding the factors that influence chemical stains have shown expression of TFF lymph node metastasis. 3 in gliomas with difference in the expression between low grade and high grade gliomas. Renal Pathology/Breast Pathology/GI Pathology: (Dr Alia Al Bawardi) 4. Role of Galectin 1, 3 in breast cancer 1. Breast carcinoma is one of the common ma- chemoresistance lignancies among UAE females. The prevalence Breast carcinoma is the most common malig- of Precancerous lesions such as flat epithelial nant neoplasm and the second cause of cancer atypia needs to be determined in breast cancer death in women all over the world. Despite all resections. Also of interest is the rare mucinous the advances in the early detection, drug resist- breast carcimonas, its prevalence and immuno- ance is a major problem in our battle against histologic characteristics. cancer. Gal-1 and Gal-3 are members of the 2. Compare Ki67 staining in vocal cord dyspla- beta-galactoside-binding family and they play a sia to histopathologic grading system of mild, role in cell proliferation, adhesion, and migra- moderate and severe dysplasia. tion. Both of them have antiapoptotic function 3. SLEEVE gastrectomy specimens are becom- hence they may play a role in cancer chemore- ing increasingly common in the era of obes- sistance. This proposal is aimed at carrying out ity epidemic. In many cases the patients are a prospective study to determine the role of also found to be positive to H pylori. There is a Gal-1 & 3 in breast cancer chemoresistance with need to estimate how many of those cases are the aim of establishing Gal-1 and Gal-3 expres- positive and if this percentage is big enough sion as a biomarker for drug resistance and to mandate change in lab policy by providing establishing a method to overcome chemore- H pylori special stain as a routine procedure on sistance by targeting Gal-1&3 expression by every SLEEVE gastrectomy specimen. using siRNAs. If successful, this would establish Gal-1&3 expression as a key prognostic marker Pediatric Pathology/Gynecologic for evaluating treatment success in breast Pathology: (Dr Saeeda Almarzooqi) carcinoma. 1. Pediatric pathology is a field of pathology unexplored in the UAE. Pediatric tumors are 5. Hypoxia inducible factor-1α and lymph unique and different from tumors we encounter node metastasis in breast carcinoma in the adult population. There are limited data Breast cancer is the most common malignancy on the incidence of these tumors in the UAE. A in women worldwide. Lymph node metastasis focus on the characteristic of pediatric tumor increases the stage of the disease and results in as it relates to our population would be of great poor prognosis. HIF-1 is a transcription factor value. and its over expression leads to up-regulation 2. Pediatric lymphoma as a group has not been of many hypoxia inducible mRNAs including studied in the UAE. In collaboration with Dr. A. vascular endothelial growth factor (VEGF), and Castella, the incidence and types of pediatric protease activated receptor-1 leading to tumor lymphomas present in our population can be progression, invasiveness and metastasis. We studied and characterized further. A prospective will study the role of HIF-1 α, PAR-1, and VEGF-C 2-3 year study would be done. as possible predictors of lymph node metasta-

67 Department of Pathology

of a case with multiple secondary 628-630. Articles in Peer- neoplasms. Case Reports in Medi- reviewed Journals cine 795037. Epub. Brodsky SV, Albawardi A, Satoskar AA, Nadasdy G, Nadasdy T. (2010). Abdelrahman AM, Al-Salam S, Almarzooqi S, Leber A, Kahwash When one plus one equals more Almahruqi AS, Al Husseni IS, S. (2010). Artifacts and organ- than two--a novel stain for renal Mansour MA, Ali BH. (2010). N- ism mimickers in pathology: case biopsies is a combination of two acetylcysteine improves renal he- examples and review of literature. classical stains. Histopathology modynamics in rats with cisplatin- Advances in Anatomical Pathology 11; 1379-1383. induced nephrotoxicity. Journal of 17(4); 277-281. Applied Toxicology 30(1); 15-21. Cantagrel V, Lefeber DJ, Ng BG, Al-Salam S, Shaaban A, Alketbi M, Guan Z, Silhavy JL, Bielas SL, Lehle Agarwal MM, Dhatt GS, Shah U Haq N, Abouchacra S. (2010). L, Hombauer H, Adamowicz M, SM. (2010). Gestational diabetes: Acute kidney injury secondary to Swiezewska E, De Brouwer AP, simplifying the IADPSG diag- renal large B cell lymphoma: role Blümel P, Sykut-Cegielska J, Houlis- nostic algorithm using fasting of early renal biopsy. International ton S, Swistun D, Ali BR, Dobyns plasma glucose. Diabetes Care 33; Urology and Nephrology. [Epub WB, Babovic-Vuksanovic D, van 2018–2020. ahead of print]. Bokhoven H, Wevers RA, Raetz CR, Freeze HH, Morava E, Al-Gazali Al-Gazali L, Ali BR. (2010). Muta- Al Samri MT, Al Shamsi M, Al- L, Gleeson JG. (2010). SRD5A3 is tions of a Country: a Mutation Salam S, Marzouqi F, Al Mansouri required for converting polyprenol Review of Single Gene Disorders A, Al-Hammadi S, Balhaj G, Al Da- to dolichol and is mutated in a in the United Arab Emirates (UAE). waar SK, Al Hanjeri RS, Benedict S, congenital glycosylation disorder. Human Mutation 31; 505 - 520. Sudhadevi M, Conca W, Penefsky Cell 142; 203-217. HS, Souid AK. (2010). Measure- Ali BH, Al-Salam S, Al Husseni I, ment of oxygen consumption by Denic S, Nagelkerke N, Agarwal Kayed R, Al-Masroori N, Al- Harthi murine tissues in vitro. J Pharma- MM. (2010). Choice of kin in con- T, Al Zaabi M, Nemmar A. (2010). col Toxicol Methods. 2010 Oct 27. sanguineous marriages: effects of Effects of Gum Arabic in Rats with [Epub ahead of print]. altruism and ecological factors. Adenine-Induced Chronic Renal Annals of Human Biology 37; Failure. Experimental Biology and Al Shamsi M, Al Samri MT, Al-Salam 738-753. Medicine, 235(3); 373-382. S, Conca W, Shaban S, Benedict S, Tariq S, Biradar AV, Penefsky HS, Mochida GH, Ganesh V, Felie J, Ali BR, Akawi NA, Chedid F, Bakir Asefa T, Souid AK. (2010). Bio- Gleason D, Hill RS, Clapham KR, M, Ur Rehman M, Rahmani M & compatibility of calcined mesopo- Rakiec D, Tan W-H, Akawi NA, Al-Gazali L. (2010). Molecular and rous silica particles with cellular Al-Saffar M, Partlow JN, Tinschert clinical analysis of Ellis-van Creveld bioenergetics in murine tissues. S, Barkovich AJ, Ali B, Al-Gazali L, syndrome in the United Arab Emir- Chemical Research in Toxicology Walsh CA. (2010). A homozygous ates. BMC Medical Genetics 11; 33. 23(11); 1796-1805. mutation in the tight junction protein JAM3 causes hemor- Ali BR, Nouvel I, Leung K F, Hume Al-Shibi A, Al-Salam S, Bernieh rhagic destruction of the brain, AN, Seabra MC. (2010). A novel B, l Matta H, Al Attrach E. (2010). subependymal calcification and Statin-mediated “prenylation Lupus Cystitis in a 14 years old congenital cataracts. American block-and-release” assay provides Omani origin female. Saudi Journal of Human Genetics 87; insight into the membrane target- Journal of Kidney Diseases and 882-889. ing mechanisms of small GTPases. Transplantation 21(5); 943-946. Biochemical and Biophysical Narchi H, Kochiyil J, Zayed R, Research Communications 397; Attoub S, Iratni R, Al-Salam S, Abdulrazzak W, Agarwal MM. 34-41. Arafat K, Al Sultan M A H, Al (2010). Maternal vitamin D status Marzouqi N, Bruyneel E, Bracke M, throughout and after pregnancy. Ali BR, Xu H-F, Akawi NA, John DeWever O, Gespach C. (2010). Journal of Obstetrics and Gynae- A, Karuvantevida NS, Al-Gazali L NF-B Inhibitor IBα negates colon cology 30;137-142. & Leitinger B. (2010). Trafficking cancer cell migration, invasion, defects and loss of ligand binding proliferation and tumor growth. Nemmar A, Al-Salam S, Zia S, are the underlying causes of all SHAMS Journal of Medical Science Dhanasekaran S, Ali BH. (2010). reported DDR2 missense muta- 3(1); 62-71. Time-course effects of systemi- tions found in SMED-SL patients. cally administered diesel exhaust Human Molecular Genetics 19; Bekdache GN, Begum M, Al-Gazali particles in rats. Toxicology Letters 2239-2250. L, Ali BR, Akawi NA, Mirghani 194(3); 58-65. H. (2010). Prenatal diagnosis of Almarzooqi S, Hammond S, thanatophoric dysplasia and Nemmar A, Al-Salam S, Zia S, Yasin Kahwash SB. (2010). Hodgkin obstetrical challenges. Journal of J, Al Husseni I, Ali BH. (2010). Die- lymphoma in a thymic cyst: report Obstetrics and Gynaecology 30; sel exhaust particles in the lung

68 Department of Pathology

aggravate experimental acute re- Acute cardiovascular effects of Dubai, UAE. nal failure. Toxicological Sciences pulmonary exposure to diesel 113(1); 267-277. exhaust particles: Protective ef- Ali BR, Xu HF, Akawi NA, John A, fect of thymoquinone. European Karuvantevida NS, Langer R, Al- Rawlinson NJ, Almarzooqi S, Nicol Respiratory Society Conference, Gazali L, Leitinger B. (2010). Traf- K. (2010). Sebaceous lymphade- Barcelona, Spain. European Respi- ficking defects and loss of ligand noma of the parotid gland in a 13- ratory Journal, No. 2543. binding are the underlying causes year-old girl: a case report. Head & of all reported DDR2 missense Neck Pathology 4(2);144-147. mutations found in Spondylo- k meta-epiphyseal dysplasia with short limbs and abnormal calcifi- k cations [SMED-SL] patients. British Proceedings, Society for Matrix Biology Meeting on: ‹Vascular Matrix in Health & Books, Chapters, Conferences, Disease›, Manchester, UK. Invited Lectures, Reviews and Edito- Almarzooqi S, Crumbacher J, rials Web Sites Firgau E, Kahwash S. (2010). and Others Immunophenotypic comparison Agarwal MM. (2010). Evolution of of peripheral blood versus bone screening and diagnostic criteria Ali BH, Al-Salam S, Nemmar A. marrow blasts in pediatric Acute for GDM worldwide. In: Gesta- (2010). The effect of diesel exhaust Leukemias. Society for Pediatric tional Diabetes During and After particles on cisplatin–induced Pathology Annual Meeting, Wash- Pregnancy. Editors: Kim C, Ferrara acute renal failure in rats. 2nd Pan- ington, DC, USA. A, Eds. Springer.pp.35-49. Arab Military Medicine, Jeddah, Saudi Arabia. Almarzooqi S, Punati J, Carvalho Al-Gazali L, Ali BR. (2010). Ge- R, Russo J, Denham J, Houston R, netic Disorders in the United Arab Ali BR. (2010). Cellular organelle Prasad V. (2010). Utility of Tissue Emirates. In “Genetic Disorders disease genomics: Endoplasmic Transglutaminase Immunostain- Among Arab Populations” (Editor: reticulum associated Protein ing in Pediatric Duodenal Biopsies: A.S. Teebi), 2nd Edition, 639-676. Degradation (ERAD) the most Patterns of expression & Role in Springer Press, Heidelberg. common mechanism of human Celiac disease; a clinicopathologic monogenic diseases. NYU Abu review. Society for Pediatric Pa- Dhabi Genomics to System Biol- thology Annual Meeting, Washing- k ogy Workshop, Abu Dhabi, UAE. ton, DC, USA.

Ali BR, Akawi NA, John A, Al-Gazali Al-Salam S. (2010). Lupus cystitis. Published L. (2010). Cellular Organelle Dis- Emirates Association of Nephrology. ease Genomics: the ER-Associated Abstracts, Protein Degradation (ERAD) is a Al-Salam S. (2010). Ethics in Animal Letters and Major Mechanism Underlying Nu- Research. The First Annual Medi- merous Human Genetic Disorders. cal and Professional Conference, Correspondence 3rd Pan Arab Genetics Conference, FMHS, UAE. November 3rd 2010. Genomics Healthcare, Dubai, UAE. Agarwal MM, Dhatt GS, Shah Qumsieh RY, Ali BR, Abdulrazzaq SM. (2010). Gestational diabetes: Ali BR, Hertecant J, Al-Jasmi F, YM, Akawi NA, Osman O, Kosa- simplifying the IADPSG diagnostic Hamdan MA, Akawi NA, Al-Gazali novic M, Nagelkerke N, Bastaki algorithm using fasting plasma L. (2010). Mutational analysis of SM. (2010). The occurrence of glucose. Response to Mahdavian a spectrum of inborn errors of mutant alleles at the CYP2D6 gene et al. Diabetes Care; 33:e146. metabolism disorders from the in Emiratis and its implications for United Arab Emirates. 3rd Pan psychiatric practice in the UAE. Ali BH, Al Salam S, Alhusseni I, Arab Genetics Conference, Ge- 3rd Pan Arab Genetics Conference, Nemmar A. (2010). Compara- nomics Healthcare, Dubai, UAE. “Genomics Healthcare”, Dubai, UAE. tive protective effect of N-acetyl cysteine and tetramethailpyrazine Ali BR, Xu H, Akawi NA, John Marzouqi F, Al Dhaheri A, Zia S, in rats with gentamicin nephro- A, Karuvantevida NS, Langer R, Dhanasekaran S, Kazzam EE, Al toxocity. Experimental Biology Leitinger B, Al-Gazali L. (2010). The Salam S, Nemmar A. (2010). As- Conference, Anaheim, California. cellular and biochemical mecha- sessment of the acute pulmonary The FASEB Journal, C144. nisms underlying Sponydylo-me- and cardiovascular effects of ta-epiphyseal dysplasia with short particulate air pollution. The 7th Nemmar A, Al-Dhaheri A, Mar- limbs and abnormal calcifications International Scientific Conference zouqi A, Zia S, Dhanasekaran S, (SMED-SL). 3rd Pan Arab Genetics for Medical Students in the GCC Al-Salam S, Kazzam EE. (2010). Conference, Genomics Healthcare, Countries, Jeddah, Saudi Arabia.

69 Department of Pathology

Sheikh Hamdan Award for Medi- Prof L Al-Gazali (PI), Dr BR Ali, Profs RESEARCH GRANTS cal Sciences O El-Agnaf, TE Adrian, E Adeghate, B al-Ramadi. FMHS Research Grants Dr S Al Salam (PI), Prof T Rizvi. A startup funding for the NRF Dr S Al Salam (PI). Prevalence of Human papilloma Genes and Diseases Research Could hypoxia inducible factor-1, virus and expression of E6, E7, p16, Center. vascular endothelial growth p53, pRb, ki-67 and bcl2 in uterine factor-C and protease activated cervical cancers in a population of Emirates Foundation Grant receptor-1 predict lymph node United Arab Emirates nationals. metastasis in breast carcinoma? Drs Al Salam (PI), M Bashir, M Drs A Nemmar (PI), S Al Salam, Prof Jaloudi. Drs A Nemmar (PI), S Al Salam. E Kazzam. Could Galectin-1 and 3 play a role Impact of particulate air pollution Mechanisms of adverse pulmo- in breast carcinoma chemoresist- on ischemic acute renal failure: nary and cardiovascular effects of ance? Possible protective effect of thymo- particulate air pollution. quinone. Drs S Bastaki (PI), BR Ali, Prof Y Terry Fox Fund for Cancer Research Abdulrazzaq. Acetylation genotyping of UAE UAEU Individual Grants Drs M Cabezudo (PI), H El-Salhat, H Taji, M Jalloudi, S Al Salam, M nationals. Dr A Nemmar (PI), S Al Salam. Rincon, Prof B al-Ramadi. Time-course and mechanisms of Novel resistance biomarkers in hu- Drs A Nemmar (PI), S Al Salam. pulmonary and extrapulmonary man breast cancer. Experimental studies on the toxicity of the systemically admin- interactions between pulmonary istered particulate air pollution in exposure to particulate air pollu- rats. tion and hypertension: Pathophysi- National Research Foundation ologic mechanisms and influence Grant of protectant drugs. UAEU Interdisciplinary Grants

Dr S Al Salam (PI), Prof S Karam, Dr Dr BR Ali (PI), Prof L Al-Gazali. A Alshawarbi. Manipulation of endoplasmic Role of Trefoil factor peptides in the reticulum protein degradation k development and progression of machinery for therapy of genetic gliomas. diseases. 2010Pathology

Standing left to right: Dr Bassam Ali, Dr Suhail Al Salam, Dr Antonio Castella, Prof Mukesh Agarwal, Dr Chong Siew Meng Seated left to right: Mr Noushad, Ms Anne Mathew, Ms Manjusha Sudhadevi, Ms Khaula Al Ghanem

http://www.fmhs.uaeu.ac.ae/Departments/Pathology Tel: 7672000 / Fax: 7671966

70 Department of Pharmacology

Research Profile

The Pharmacology Department has special Professor & Chair: interests in Diabetes and Degenerative Prof A Adem Professor: Diseases, Neuroscience, Clinical Toxicology, Prof MY Hasan Gastroenterology and Oncology. The research Associate Professors: is done with state of the art equipment Dr S Attoub Dr S Bastaki in purpose-built laboratories with good Dr M Oz technical and other support. Medical Research Specialist: Ms N Amir Ms K Arafat Mr S Dhanasekaran Prof. Abdu Adem Dr SM Nurulain Diabetes Mr A Shamsulisam Mechanisms of Apoptotic Cell Death in Diabetes Medical Secretary: In almost all multicellular organisms, cell suicide or apoptosis Ms S Duncan appears to play an important role in the maintenance of cellular Office Assistant homeostasis. Apoptosis is tightly regulated by a set of genes that Mr S. Alikutty either promote apoptosis or promote cell survival. Although a number of stimuli appear to trigger the process of apoptosis, Central Facilities (Animal there are two major signaling pathways of apoptosis: the death House) Medical Research Specialist Dr M Al Sultan Mr M Shafiullah Mr M El Wasila

71 Department of Pharmacology

receptor pathway and the death receptor-in- for some of the changes observed in aging, dependent or mitochondrial pathway. Mecha- diabetes and Parkinson’s disease. Another line nisms of apoptotic cell death are being studied of research has been toxicological studies and in kidneys of an animal model of diabetes. The impact of toxins on muscle the nervous sys- ultra structural features in the tubules seem to tem. We have investigated the effects of heavy implicate apoptosis in the pathology of renal metal Intoxication in relation to degenerative nephropathy. In addition we reported, for the diseases. We studied impact of heavy metal first time, a significant loss of foot processes of toxicity on nervous system and muscle and podocytes (*) in the diabetic rat kidney (Fig.1 observed that free radicals may be involved in left). These findings could contribute to the un- metal toxicity and antioxidants like ascorbic derstanding of the patho-physiology of diabetic acid & alpha-tocopherol may have a protective nephropathy. role against metals effects Also we have been looking and neurotoxicity and general toxicity Neurodegenerative Diseases from organophosphates and nerve gases. We Novel Selective Ligands for Muscarinic have been screening antidotes for organophos- Acetylcholine Receptors phate poisoning and implication for treating Five muscarinic acetylcholine receptor subtypes exposure to nerve gas agents. Furthermore (M1- M5) have been cloned and are found in the my interest covered broad areas in medical brain. However, the pharmacological identifica- education and community health. Some of the tion of the subtypes responsible for the various projects performed included; drug utilization central effects of the muscarinic drugs is difficult and rational use of antibiotics and analgesics in due to the lack of highly selective muscarinic health care centers and community, develop- agonists and antagonists. We have isolated mus- ing Sickness Impact Profile for studying quality carinic M1 and M4 receptor subtype selective of life in infertile patients, studying views of toxins from mamba snake (Dendroaspis) ven- medical students and physicians of clinical skills oms. At present the status of M1 and M4 recep- teaching at the medical colleges and surveying tors in health and disease states in humans are patient’s attitudes towards students involve- being investigated. Our results show significant ment in medical practice. decrease of M4, but not of M1 receptors in the hippocampus of Alzheimer’s patients compared Dr. Salim Bastaki to controls. Moreover, changes in these recep- Gastroenterology: Gastrointestinal diseases tors in adrenalectomized animal models which have increased in recent years. Work stress, have been shown to have a selective loss of alcohol, non-steroidal anti-inflammatory drugs hippocampal neurons. Attempts to isolate and (NSAIDS) strong tea or coffees have contributed characterize M2, M3, and M5 selective toxins is to the pathology. Our research is based on also in progress. Behavioral, biochemical and gastrointestinal secretion and the mechanism electrophysiological techniques are also used in of action of PPIs and other acid inhibitors on understanding the role of other neurotransmit- acid secretion. In the early years, Histamine H2- ters in diabetes, epilepsy, aggressive behavior, receptor antagonist, Sucralfate and Muscarinic aging, and degenerative diseases. receptor antagonists were used more often. But with the introduction of the proton pump Prof. MY Hasan inhibitors (PPIs) their use has declined owing to Neuroscience the potent anti-secretory and anti-ulcer activ- The main line of research has been focusing ity of the PPIs. Recently we published the work on neurotransmission. We have been ap- on new proton pump inhibitor, esomeprazole, plying behavioral, biochemical and electro- Astra-Zeneca (accepted for publication (2008)). physiological and morphological techniques At present we are studying the interactions of in understanding the role of neurotransmitters Aspirin in combination with ibuprofen on Gas- in various disorders (diabetes, epilepsy, aging, tric acid and Ulcer formation in the rat in vivo neurodegenerative diseases). Findings indicated and in vitro (manuscript in preparation). In the significant modification of specific neurotrans- near future we are planning to study the effect mitters in many of the disorders. It appears that of stress on the mucosa of FSL and FRL rats and alteration in calcium mobilization and free radi- the healing rate of alcohol-and indomethacin- cal system may be a common factor accounting induced ulcers in the same rats.

72 Department of Pharmacology

Teratology: Epilepsy affects approximately 1% on the functions of ion channels are the major of the world’s population and it is the second research topics investigated in his laboratory. most common neurologic disorder after stroke. It is a heterogeneous symptom complex—a Dr. Samir Attoub chronic disorder characterized by chronic Cancer research seizures. Approximately 0.5% of all pregnancies My research is focused on the role of PI3K/Akt/ occur in women with epilepsy. It is known that NFκβ pathway as a driving force behind lung epileptic women demonstrate a higher liability and colon cancer progression (apoptosis, inva- to obstetric complication than non-epileptic sion, angiogenesis and metastasis) using siRNA females and congenital malformations are technology and in parallel screening of potential more common in their offsprings than those of anti-cancer drugs. normal or rats. 1. Identification of Akt isoforms involved in Pharmacogenetics: Oxidation by enzymes en- colon cancer survival and invasion coded at the CYP2D6 locus is the main route of elimination for a large number of drugs includ- The PI3K/Akt/NFκB signaling cascade is con- ing many commonly prescribed in psychiatric stitutively activated in cancers. Akt is linked to practice such as antidepressants and neurolep- the transforming activity of c-src, c-kit, c-met tics. The CYP2D6 locus is highly polymorphic oncogenes and growth factors, such as EGF and and numerous mutant CYP2D6 alleles are IGF receptors. Drugs targeting receptor tyrosine currently known including defective alleles kinases (ErbB2/HER2 and ABL/c-kit) impact the which yield no functional protein product and PI3K/Akt pathway. Consequently, the inhibition duplicated active alleles which cause ultrarapid of Akt is considered to be an attractive cancer oxidation. Two CYP2D6 oxidation phenotypes therapeutic target. Three isoforms of Akt (Akt1/ EM (extensive metabolisers) and PM (poor PKBα, Akt2/PKBβ, and Akt3/PKBγ) are over-ex- metabolisers) are commonly recognized. These pressed and activated in cancers, but the degree phenotypes can be accurately predicted by gen- of functional redundancy between them on otyping. The clinical implications of the CYP2D6 cancer cell survival and invasion are unclear. The polymorphism are of potential importance to identification of the Akt isoform that is the most psychiatric practice in the UAE since tricyclic promising target for cancer therapy is unknown antidepressants are widely prescribed for treat- and will be addressed in the following specific ment of depression. These drugs have a small objectives: therapeutic index and unpleasant side-effects a. To explore the respective roles of Akt-1, -2 or therapeutic failure is commonly encountered and -3 in cancer cell survival, invasion, tumor when fixed dose regimens are used. There are growth and metastasis, studies will be conduct- only very few and conflicting data concerning ed using RNA interference technology in LNM35 the distribution of CYP2D6 phenotypes in Arab human lung cancer cells and HT29 human colon populations and no genotyping studies have cancer cells. ever been carried out. We aim to determine the b. To characterize the ability of different iso- frequency of the most common CYP2D6 alleles forms of Akt (Akt-1, -2 and -3) to transactivate in the local population using allele specific PCR different subsets of target genes to orchestrate methodology and to assess the relevance of the either cell survival or invasion. This will be CYP2D6 polymorphism to psychiatric practice in investigated in colon and lung cancer cells using the UAE. microarray analysis.

Dr. Murat Ahmet Oz The effects of knockdown of Akt-1, -2 or -3 on Research interest of Dr. Oz focuses on the identi- cellular survival will be determined by cellular fication of ion channels and neuronal networks viability, DNA fragmentation, cell cycle and upon which neuropharmacologically active TUNEL assays, caspases activity, PARP cleav- agents act to modulate neuronal excitability. age, cytochrome-c release and expression of To this end, actions of neuropeptides such as pro- and anti- apoptotic proteins. The impact vasopressin, angiotensin, and cholecystokinin of Akt-1, -2 or -3 silencing on invasion will be on the spinal cord preparations and the effects investigated using the collagen type I and the of bioactive lipids such as endocannabinoids chick heart invasion assays, cell-cell and cell-ma-

73 Department of Pharmacology

trix adhesion and expression of E-Cadherin. The 2. Screening of potential anti-cancer com- effect of knock down of the Akt’s on HT29 cell pounds using in vitro and in vivo assays line on tumour growth will be tested in nude mice. In addition, we will asses the develop- The overall goals of this part of my research are ment of new blood vessels (CD31 antibody), the directed towards studying the in vitro and in presence of apoptotic cells (caspase 3 activity), vivo cytotoxic properties of the synthesized/pu- and proliferative activity (ki67 antibody). We’ll rified drugs (Luteolin, Thymoquinone and test the therapeutic impact of the Akt isoforms Frondoside A). The effective drugs will be further inhibition on metastasis using the highly investigated in order to determine their mecha- invasive and metastatic lung cancer cell line nisms of action using various molecular biologi- LNM35 targeting the lymph nodes and lungs. cal techniques. In addition, we will attempt to This cell line is stably transfected with a vector investigate the effects of these drugs on cell encoding luciferase, to allow a rapid and reliable survival and invasion in vitro and on tumor quantification of micro-metastases. To identify growth in vivo. The effects on metastasis in nude the mechanisms underlying the effects of Akt mice using various cancer cell lines will also be isoform inhibition, we will search for differen- investigated. tially expressed genes using microarray analysis and confirm the results by real-time RT-PCR. It is anticipated that this project will provide evidence that targeting Akt-1 and/or -2 is a promising strategy for the treatment of colon and lung cancer.

74 Department of Pharmacology

Kalász H, Hasan MY, Adeghate E, Yang KH, Galadari S, Isaev D, Articles in Peer- Tekes K, Adem A. (2010). Chroma- Petroianu G, Shippenberg TS, Oz reviewed Journals tographic separation of antiviral/ M. (2010). The nonpsychoactive anticancer nucleoside reverse cannabinoid cannabidiol inhibits Alptekin A, Galadari S, Shuba Y, transcriptase inhibitor drugs. Anal 5-hydroxytryptamine3A receptor- Petroianu G, Oz M. (2010). The Bioanal Chem. 398: 295-312. mediated currents in Xenopus effects of anandamide transport laevis oocytes. J Pharmacol Exp inhibitor AM404 on voltage- Mao XJ, Zhang XM, Zhang HL, Ther. 333:547-554. dependent calcium channels. Eur J Quezada HC, Mix E, Yang X, Pharmacol. 634:10-15. Winblad B, Adem A, Zhu J. (2010). TNF-alpha receptor 1 deficiency k Attoub S, Hassan AH, Vanhoecke reduces antigen-presenting B, Iratn Ri, Gaben AM, Bracke M, capacity of Schwann cells and Awad S, John A, Kamalboor HA, Al ameliorates experimental autoim- Published Sultan MAH, Arafat K, Petroianu mune neuritis in mice. Neurosci G. (2010). Inhibition of cell sur- Lett. 470: 19-23. Abstracts, vival, tumor growth and histone Letters and deacetylase (HDAC) activity by the Oz M, Jaligam V, Galadari S, dietary flavonoid luteolin in hu- Petroianu G, Shuba YM, Shippen- Correspondence man epithelioid cancer cells. Eur. J. berg TS. (2010).The endogenous Pharmacology. cannabinoid, anandamide, inhibits Isaev D, Al Mansouri AS, Lorke DE, dopamine transporter function by Nurulain SM, Hasan M, Petroianu Attoub S, Iratni R, Al-Salam S, Ara- a receptor-independent mecha- G, Oz M. (2010). Demethylated de- fat K, Al Sultan MAH, Al Marzouqi nism. J Neurochem. 112:1454- rivatives of methylene blue inhibit N, Bruyneel E, Bracke M, De Wever 1464. the function of human alpha7 O, Gespach C. (2010). The NF- nicotinic acetylcholine receptors. *inhibitor negates colon cancer Oz M, Libby T, Kivell B, Jaligam V, Soc. for Neurosci, 39.6/F43 cell migration, invasion, prolifera- Ramamoorthy S, and Shippenberg tion and tumor growth. Journal of TS. (2010). Real-time, spatially Isaeva E, Ashour AK, Nurulain SM, Medical Sciences 3: 62-71. resolved analysis of serotonin Hasan M, Petroianu G, Shippen- transporter activity and regulation berg T, Oz M. (2010). Phenothi- Bastaki SA, Abdulrazzaq YM, Os- using the fluorescent substrate, azine class antipsychotics inhibit man N, Kochiyil J, Padmanabhan R. ASP+. J Neurochem. 114:1019- the function of human alpha7 (2010). Toxicokinetics of aflatoxin 1029. nicotinic acetylcholine receptors. in pregnant mice. Int J Toxicol,. Soc. for Neurosci, 880.22/NN13. 29:425-31. Padmanabhan R, Abdulrazzaq YM, Bastaki SMA, Nurulain M, and Oz M, Lorke DE, Nurulain SM, Bastaki SM, Adeghate E, Chan- Shafiullah M. (2010). Vigabatrin Hasan M, Suid AK, Petroianu G, dranath IS, Amir N, Tariq S, (VGB) administered during late Shippenberg T. (2010). Methylene Hameed RS, Adem A. (2010). gestation lowers maternal folate blue inhibits the function of hu- Effects of streptozotocin-induced concentration and causes preg- man alpha7 nicotinic acetylcho- long-term diabetes on parietal cell nancy loss, fetal growth restriction line receptors. Soc. for Neurosci, function and morphology in rats. and skeletal hypoplasia in the 39.5/F42. Mol Cell Biochem. 341: 43-50. mouse. Reprod Toxicol;29:366-377. Safieh-Garabedian B, El-Agnaf N, Saade NE, Nurulain SM, Oz M. Fernandez-Cabezudo MJ, Lorke Salem KA, Qureshi A, Ljubisavi- DE, Azimullah S, Mechkarska M, (2010). Thymulin related peptide jevic M, Oz M, Isaev D, Hussain (PAT) potentiates the function of Hasan MY, Petroianu GA, al- M, Howarth FC. (2010).Alloxan Ramadi BK.(2010). Cholinergic human α7-nicotinic acetylcholine reduces amplitude of ventricular receptor (α7-nachr) expressed in stimulation of the immune system myocyte shortening and intracel- protects against lethal infection xenopus oocytes. Soc. for Neuro- lular Ca2+ without altering L-type sci, 692.10/GGG18 by Salmonella enterica serovar Ca2+ current, sarcoplasmic reticu- Typhimurium. Immunology. 130: lum Ca2+ content or myofilament 388-98. Shippenberg T, Jaligam V, Oz M, sensitivity to Ca2+ in Wistar rats. Mannangatti P, Jayanthi LD, Rama- Mol Cell Biochem. 340:115-123. Kalász H, Adem A, Hasan MY, moorthy S. (2010). K-opioid recep- Adeghate E, Ram N, Gulyás tor agonists regulate serotonin Yang KH, Galadari S, Isaev D, transporter function, phosphor- Z, Tekes K. (2010). Medicinal Petroianu G, Morales, M., Oz chemistry of antiviral/anticancer ylation and cell surface expression. M. (2010). The effect of Δ9- Soc. for Neurosci, 741.16/D34. prodrugs subjected to phosphate tetrahydrocannabinol on 5-HT3 conjugation. Mini Rev Med Chem. receptors depends on the current 10: 822-45. Yang K-H, Isaev D., Galadari S, and density. Neuroscience. 171: 40-49. Oz M. (2010). The endogenous

75 Department of Pharmacology

cannabinoid anandamide inhibits serum Il-23 levels and histological Acetylcholine Receptors Expressed the function of human serotonin parameters in acetic-acid-induced in Xenopus Oocytes. transporter. Soc. for Neurosci, inflammatory Bowel Disease in 545.7/F21. rats. Meeting of the Asian Pacific Emirates Foundation Digestive Week, in Kuala Lumpur, Malaysia. Prof Abdu Adem. Search for Novel Anti-diabetic k Iratni R, Attoub S, Hassan AH, drug candidates Vanhoecke B, Gaben AM, Bracke M, Al-Sultan M, Arafat K, Gespach Dr Salim Bastaki. Proceedings, C, Petroianu G. (2010). Inhibition NAT2 acetylation phenotyping/ of cell survival, tumor growth genotyping of Emiratis. Conferences, and histone deacetylase (HDAC) Invited Lectures, activity by the dietary flavonoid National Research Foundation luteolin in human epithelioid Web Sites cancer cells. European Association Dr Murat Oz. for Cancer Research 21 (EACR 21), The Effects of Endocannabinoids and Others Oslo, Norway. on the Function of Nicotinic Adem A, Zhu W, Zhang K, Mix E, Acetylcholine Receptors of the Zhu J. (2010). Differential Suscep- Qumsieh RY, Bastaki SM, Akawi Hippocampal Interneurons. tibilities to Experimental Autoim- NA, Abdulrazaaq YM, Kosanovic mune Neuritis In Lewis Rat Strains. M, Nagelkerke N, Ali BR. (2010). Sheikh Hamdan Medical Alzheimer’s Association Interna- The occurrence of mutant alleles Research Grant tional Conference on Alzheimer’s at CYP2D6 gene locus in UAE Disease 2010, July 10 to 15, Hawii, Nationals and its implications for Prof. MY Hasan Honolulu, USA. psychiatric practice. Third Pan Effect of environmental factors on Arab Human Genetics Conference, chronic experimental neurode- Al Marzouqi N, Arafat K, Iratni R, Abu Dhabi. generation. Nemmar A, Gaben AM, Mester J, Al Sultan MAH, Collin P, Gespach C, Adrian TE, Attoub S. (2010). Effects k of Frondoside A on breast cancer k cell survival, migration and inva- sion in vitro and tumour growth RESEARCH GRANTS in vivo. 12th Milan Breast Cancer Conference, Milan, Italy. FMHS New grant

Al Marzouqi N, Iratni R, Arafat K, Prof. Abdu Adem. Gaben AM, Mester J, Al Sultan NP/10/37 - The Role of TNF-ά in MAH, Nemmar A, Woodward C, the Kainic Acid-induced Excito- Collin P, Gespach C, Adrian TE, toxic Neurodegeneration Attoub S. (2010). Frondoside A induces cancer cell death, inhibits Dr Samir Attoub. cellular invasion, and decreases Investigation of IKKalpha and the growth of breast tumour xe- beta role in human breast cancer nografts in athymic mice. DUPHAT survival, motility and invasion. Conference, DUBAI, UAE. UAEU Individual grant Al Marzouqi N, Iratni R, Arafat K, Gaben AM, Mester J, Al Sultan Dr. Salim Bastaki MAH, Nemmar A, Woodward C, Effect of TNF-alpha deficient Collin P, Gespach C, Adrian TE, mice on gastric ulcers induced by Attoub S. (2010). Frondoside A Indomethacin. inhibits human breast cancer cell survival, invasion, and the growth Dr Samir Attoub. of breast tumor xenografts in Investigation of Frondoside A as a athymic mice. 2nd International potential inhibitor of lung cancer Conference on Drug Discovery cell survival and invasion in vitro and Therapy, Dubai, UAE. and tumour growth and metasta- sis in vivo Bastaki SMA, Amir N, Adeghate E. (2010) Effects of turmeric on Dr Murat Oz . Oleamide Modulation of Nicotinic

76 Department of Pharmacology

2010Pharmacology

Standing left to right: Ms Naheed Amir, Mr N Shafiullah, Mr D Subramanian, Dr S Bastaki, Mr M Elwasila, Mr S M Nurulain, Mr S Alikutty, Mr A Shamsulisam, Dr M Al Sultan. Seated left to right: Professor Huba Kalasz, Ms S Duncan, Professor A Adem, Dr S Attoub, Ms K Arafat, Dr M Oz

http://www.fmhs.uaeu.ac.ae/Departments/Pharmacology. Tel: 7672000 / Fax: 7672033

77 Department of Physiology

Research Profile

Professor & Chair: Members of Staff of the Physiology Department Prof TE Adrian have interests in neuroscience and muscle Professor: Prof M Fahim (including skeletal, cardiac and smooth Prof C Howarth muscle). The experimental work includes Prof W Lammers normal physiology as well as pathophysiology, Prof M Ljubisavljevic Associate Professor: particularly in relation to the peripheral nerves, Dr A Nemmar autonomic nervous system, and heart in the Medical Research diabetic state, which is a common disorder in Specialist: Mr J Oommen the United Arab Emirates. The work requires Ms K Parekh complex electrophysiological and cellular Mr A Qureshi methodologies, as well as electron microscopy, Ms B Stephen Ms S Zia using in vitro and in vivo techniques. Other MedicalResearch departmental research interests include uterine Technician: smooth muscle physiology, cardiovascular and Ms GA Kanu Ms SA Thomas pulmonary effects of particulate air pollution, Secretary: cancer biology, as well as novel therapeutics for Mr P Rajagopalan cancer, type 2 diabetes mellitus, and obesity. Office Assistant: Mr Saeed C

Electrophysiology and clinical neurophysiology laboratories The research activities of the electrophysiology laboratory focuses on skeletal muscle function and muscle pain. The main techniques employed are classical electrophysiological tech- niques (EMG, ENG, muscle force and velocity, single fiber and single unit-extracellular/intracellular recordings). We have also recently introduced at FMHS the set of small animal behavioral techniques including Morris Water Maze, T and Y maze, coordi- nation and balance motor testing etc. Currently, in collabora- tion with several colleagues we are focusing on validation of behavioral abnormalities in Rotenone rat model of Pakinson’s disease. We are also planning to introduce multiunit recording by implementing multisite cell recordings in order to investigate in more details the plasticity changes of spinal cord pain process- ing neural networks. We are particularly interested to elucidate

78 Department of Physiology

differences between cervical and spinal neu- antioxidants like vitamin E & C may have a pro- ral networks as they may exhibit differential tective role. Studies on the cerebral microcir- processing in chronic muscle pain conditions culation include changes in the susceptibilty to which are clinically quite different in these two thrombus formation in the brain, and the effects regions. Initially, this work will focus on possible of metals, aspirin and heat involvement of basal ganglia in chronic pain modulation. The Clinical neurophysiology laboratory uses Cardiovascular function and diabetes Transcranial Magnetic Stimulation (TMS) Professor Chris Howarth (Physiology) and Dr and other classical Clinical neurophysiology Murat Oz (Pharmacology) are in the process methods (H and F wave, Evoked potentials) to of establishing an Electrophysiology Centre in investigate mechanisms of human nervous sys- FMHS. This multidisciplinary centre has a wide tem plasticity and the possibilities to remodel variety of technical capabilities which include these processes in healthy subjects and several tissue culture; cell isolation; in vivo biotelem- diseases. We primarily focus on movement dis- etry; hemodynamic and electrophysiology in orders. Dr. Ljubisavljevic’s special interests over isolated perfused heart; patch clamp, micro- the years were cortical processes related to voli- electrode, fluorescence photometry and video tion in exercise and fatigue. The work focuses edge motion detection in single and multicel- on mechanisms associated with sensorimotor lular preparations. The research centre already integration and maladaptive plasticity in central has ongoing collaborations with colleagues fatigue. In collaboration with colleagues from in different departments in FMHS and with the Institute for Neurology, University Clinical colleagues in the UK, USA and Ukraine. The re- Center Belgrade, we are also investigating the search team includes MSc, PhD and undergrad- character of pathophysiological maladaptive uate students, research collaborators visiting on cortical processes in Parkinson’s dystonia and a regular basis from international research labo- tremor. Finally, in collaboration with neurology ratories and technical staff. The major research division and ENT department of Tawam Johns focus of Professor Chris Howarth is diabetes Hopkins Hospital we are currently developing and heart function with particular emphasis on a set of clinical experimental and therapeutic experimental models of type 2 diabetes. TMS protocols for Multiple Sclerosis, stroke and chronic idiopathic tinnitus patients.

Aging and neurodegenerative disorders Studies on aging and neurodegenerative dis- orders have focused on synaptic plasticity and synaptic remodelling, particularly at the nerve- muscle junction in various peripheral neuropa- thies including those caused by diabetes, aging and heavy metal poisoning. Electrophysiologi- cal, laser confocal microscopy and electronmi- croscopy techniques are used in combination to focus on changes in muscular performance in these conditions. It is hypothesised that free radicals are involved in these nerve injuries and

Mapping laboratory Work has proceeded very well in 2010 with ma- jor research developments obtained both in Al Ain and through our collaborations with other laboratories in the world. Probably the most important development has been the work and publication of the first high- resolution recordings in the human stomach.

79 Department of Physiology

This work, that was performed on patients at the propagation of the slow wave in diabetic small University of Auckland, New Zealand, is the first intestine of the rat. In this study, we show that demonstration of the location of the stomach in spite of a reduction of Interstitial Cells of Cajal pacemaker and the propagation of the electri- at 3-months diabetes, there is no effect on the cal impulse, the slow wave, through the distal propagation of the slow wave. However, we re- fundus, the corpus and the antrum. We had cently discovered in this model the occurrence described last year similar variations in propa- of functional re-entries in these small intestines, gation in the canine model and this progress which could be the substrate for functional was further expanded by another study, again bowel obstruction. We hope to report this in achieved this year, on the pig stomach. All this more detail in next year’s edition. has led to an invitation to map the electrical e) As before, in the FMHS summer research propagation in gastroparetic patients, work that program, we collaborated, this year, with Ms is currently underway at the Mississippi Medical Shaikha Al-Sharif (then OSC2). Shaikha investi- Center, Jackson, MI, USA in collaboration with gated the spontaneous contraction pattern of the Farrugia group at the Mayo Clinic in Roches- the isolated pregnant rat uterus by placing 35- ter, USA 100 markers on their serosal surface and video mapping their displacements. This work led to

Figure: Description of the human gastric conduction system with a) high amplitude isotropic propagation in the pacemaker area, b) slow propagation in the corpus and c) fast propagation in the antrum. In addition, there are simultaneously present at least 4 different propagating wave fronts in the stomach as indicated by the brown lines. G O’Grady et al Am J Physiol Gastrointest Liver Physiol 299: G585-92, 2010

Other collaborative achievements, in Al Ain or the surprising finding that, in this model, con- elsewhere have been: traction does not always follow electrical propa- a) the analysis of contractions of isolated Inter- gation and that there is a mismatch between stitial Cells of Cajal, originally recorded by the electrical and contractile activity. We have legendary Lars Thuneberg, together with the lab submitted these initial results in an abstract of Jan Huizinga at McMaster, Hamilton, Canada that has meanwhile been accepted for presen- b) at FMHS, Al Ain, the on-going study with tation at the annual Society for Gynecological Fayez Hammad, dept of Surgery, on our ob- Investigations that will take place in March 2011 structed ureter model, work that is ongoing with in Miami, USA and wrote a new grant proposal a new attempt to map the urinary baldder for the annual FMHS research program that will c) a visit by Dr Hassiba Benabdallah, from the hopefully be awarded. Faculty of Science, University of Setif, Algeria, on f) Following on our successful presentation on the effects of Quercetin on intestinal motility. the origins of myometrial contractions in the d) With Professor Sherif Karam, the study of the pregnant guinea-pig uterus (Glasgow 2009),

80 Department of Physiology

we continued our work on the search of the gies are extensively publicized, the discussion pacemaker of the pregnant uterus of which we of the potential effects of the widespread use now have evidence that this is located along the of nanotechnology in consumer and industrial mesenteric border of that organ. products is just beginning to emerge. In my lab- g) We have continued our very successful col- oratory, we are investigating the biokinetics and laboration with the Bioengineering group in the pulmonary and cardiovascular toxicological Auckland, New Zealand (Pullan, Cheng, O’Grady potential of engineered nanoparticles. Studies et al) and expanded with a new collaboration on the pulmonary and extrapulmonary effects with the Gastroparesis group at Jackson, Mis- of particle shapes (e.g., spheres, tubes, rods), sissippi, USA where we are currently perform- chemistries (e.g., polystyrene, TiO2, FeTiO2, ing high resolution mapping of gastroparetic carbon) and surface characteristics (iron coating, patients who are refractory to drug treatments. charge) are being investigated. These studies involve in vivo and in vitro investigations. But the highlight of the year 2010 must undoubtedly be the invitation by the editorial board of our journal, Neurogastroenterology The cancer laboratory & Motility, to contribute to a special edition of The overall thrust of the pancreatic cancer “Emerging Excellence in Neurogastroenterology program is elucidating the molecular mecha- & Motility”, a prize that we shared with a group nisms underlying its rapid growth and invasion in Brazil and another in China. and in developing novel strategies to treat it. Prof. Adrian investigates various aspects of this pancreatic cancer, including growth and dif- Pathophysiologic mechanisms of particulate ferentiation signaling pathways, the role of the air pollution lipoxygenase pathways in tumor growth and es- Air pollution from road traffic is a serious health cape from apoptosis, the interactions between hazard, and particulates have become cause for pancreatic cancer cells and the pancreatic increasing concern. The UAE has seen tre- endocrine islet tissue, as well as the reasons for mendous growth in road traffic during the last the severe metabolic disturbance and cachexia fifteen years resulting in a significant increase in that accompany this devastating disease. With vehicular air pollution. In the major cities such as his collaborators, he has developed some novel Abu Dhabi, Dubai or Sharjah, vehicle emissions therapeutic agents, one of which recently en- are currently considered as one of the greatest tered clinical trials. New anti-cancer compounds contributors to urban air pollution. Inhaled par- have been isolated from marine organisms, ticulate air pollution with diameter below than including the sea cucumber. The mechanisms by 2.5 μm contributes to respiratory and cardiovas- which these agents cause cell cycle arrest and cular morbidity and mortality. induce apoptosis in cancer cells are currently Diabetes, hypertension and renal failure are under investigation. Recently, he has used oligo- considered as major health problems in the UAE nucleotide microarrays to identify novel growth- and the world at large. Not only the medical related genes from their expressed sequence complications life-threatening but the cost of tags and this has led to the discovery of a new treatment is imposing enormous and increasing tumor suppressor gene in the endoplasmic strains on national health budgets. In my labo- reticulum. ratory we are studying mechanisms underlying In other studies we have shown that the sea the effects of air pollution on diabetes, hyper- cucumber-derived triterpene glycoside, frondo- tension and renal failure. I also aim at searching side A causes marked growth inhibition of hu- novel pharmacological agents that can amel- man pancreatic cancer cells, both in vitro and in iorate or prevent the toxicity of air pollution. vivo. Frondoside A causes apoptosis of the can- Nanotechnology is a broad interdisciplinary area cer cells via the mitochondrial pathway. We have of research, grouping physical, chemical, bio- rectnly shown that frondoside A has synergistic logical, and engineering expertise involved in anti-cancer effects when combined with gem- manufacturing materials at a sub–100-nm scale. citabine, the standard therapeutic agent used Whereas benefits of nanotechnology in areas in this disease. Studies are underway to identify as diverse as diagnosis, imaging, drug delivery, the mechanism of action of frondoside A. and information and communication technolo-

81 Department of Physiology

Relative expression of mRNA for VIP, neuronal NOS (NOS1), NOS2, somatostatin, and CCK in pelvic ganglia from control rats and diabetic rats 12 weeks after treatment with streptozotocin. Real-time RT-PCR confirmation of low density gene expression array data, n=8 in each group. Early changes in expression of several genes, including calpain 3, and several crystallins, in the retina have been seen in three different models of diabetes in the rat. Changes in expression of these genes are likely to be involved in the pathophysiology of glaucoma and diabetic retinopathy.

Diabetic neuropathy and retinopathy with highest concentrations in the rectum. We Changes in gene expression in the diabetic eye, have previously shown that intracolonic infu- in sympathetic and dorsal root ganglia, corpus sion of bile salts in humans causes secretion of cavernosum and vascular tissues were investi- L-cell hormones, triggered via TGR5 membrane gated by low density expression array in studies receptors. Together with colleagues in the funded by the Emirates Foundation and the Department of Internal Medicine, Prof. Adrian FMHS by Professors Adrian and Morrison. Sever- has been investigating release of these lower GI al interesting early changes in gene expression hormones in obese patients with type 2 diabe- were seen, particularly in the retinas of diabetic tes mellitus. Using a simple and well-tolerated animals. Ongoing studies include confirmation agent, this group has shown substantial in- of the expression changes using fast real-time creases in circulating concentrations of GLP-1, RT-PCR and immunocytochemistry for the PYY and insulin. The release of the lower GI protein products of these genes in collaboration hormones resulted in a fall in circulating glucose with Dr. Eric Mensah-Brown in the Department levels and a marked reduction in spontaneous of Anatomy. Marked changes in gene expression caloric intake of a subsequent meal. This mecha- have been documented. For example, in the nism is likely to be valuable in the treatment pelvic ganglia from diabetic animals the expres- of type 2 diabetes and obesity. Investigations sion of vasoactive intestinal polypeptide (VIP) focused on the improvement of diabetic status and neuronal nitric oxide synthase (nNOS) are and reduction in body weight with chronic dramatically reduced in diabetic animals, while administration of bile salts are planned. expression of another transmitter, Cholecysto- kinin (CCK) is dramatically increased. Since VIP and nNOS play a role in penile erection and in control of bladder function, these changes are likely to explain the erectile dysfunction and for urinary retention that are seen in diabetics.

Clinical studies on lower gastointestinal hormones in diabetes and obesity Enteroendocrine L-cells produce glucagon gene products (GLP-1 and oxyntomodulin) as well as PYY. All are satiety factors. GLP 1 is also an incretin. The number of L-cells and hormonal contents increases distally through the gut

82 Department of Physiology

Articles in Peer- term exercise on ventricular myo- cyte shortening and intracellular O’Grady G, Du P, Cheng LK, Egbuji reviewed Journals Ca2+ in streptozotocin – induced JU, Lammers WJEP, Windsor JA, diabetic rat. Journal of Diabetes & Pullan AJ. (2010). The origin and Ali BH, Al-Salam S, Al Husseni I, its Complications 24(4): 278-285. propagation of human gastric Kayed R, Al-Masroori N, Al- Harthi slow wave activity defined by high T, Al Zaabi M, and Nemmar A. Huizinga JD, Lammers WJEP, resolution mapping. Am J Physiol (2010). Effects of Gum Arabic Mikkelsen HB, Zhu Y, Wang Gastrointest Liver Physiol 299: in Rats with Adenine-Induced XY. (2010). Toward a concept G585-G592. Chronic Renal Failure. Exp Biol of stretch-coupling in smooth Med (Maywood); 235: 373-382. IF: muscle: a thesis by Lars Thuneberg 2.635. Roginsky AB, Ding XZ, Wood- on contractile activity in neonatal ward C, Ujiki MB, Singh B, Bell interstitial cells of Cajal. Anat Rec RH Jr, Collin P, Adrian TE. (2010). Cheon EC, Strouch MJ, Barron 293, 1543-1552. MR, Ding Y, Melstrom LG, Krantz Anti-pancreatic cancer effects of a SB, Mullapadi B, Adrian K, Rao S, polar extract from the edible sea Adrian TE, Bentrem DJ, Grippo Lammers WJEP, Karam SM. (2010). cucumber, Cucumaria frondosa. PJ. (2010). Alteration of strain Neurogastroenterology and motil- Pancreas 39:646-52. background and a high omega-6 ity around the world; emerging fat diet induces earlier onset of excellence in neurogastroenterol- Salem KA, Qureshi A, Ljubisav- pancreatic neoplasia in EL-Kras ogy and motility research in the ljevic M, Oz M, Isaev D, Hussain transgenic mice. Int J Cancer. Arabian Peninsula. Neurogastro- M, Howarth FC. (2010). Alloxan [Epub ahead of print] PMID: enterology & Motility, 22, 946-949. reduces amplitude of ventricular 20725998. myocyte shortening and intracel- lular Ca2+ without altering L-type Ljubisavljevic M, Qureshi A, Ca2+ current, sarcoplasmic reticu- Egbuji JU, O’Grady G, Du P, Cheng Nagelkerke N. (2010) The effects of LK, Lammers WJEP, (2010). Windsor lum Ca2+ content or myofilament neuropeptide Y on skeletal muscle sensitivity to Ca2+ in Wistar rats. JA, Pullan AJ. Origin, propagation contractile properties in strep- and regional characteristics of Molecular & Cellular Biochemistry tozotocin diabetic rats. Mol Cell 340(1-2): 115-123. porcine gastric slow wave activity Biochem 333(1-2):27-32. determined by high-resolution mapping. Neurogastroenterology & Motility 22, e292-e300, 2010. Nemmar A, Al-Salam S, Zia S, k Dhanasekaran S, Ali BH. (2010). Time-course effects of systemically Hammad FT, Lammers WJ, administered diesel exhaust parti- Books, Chapters, Stephen B, Lubbad L. (2010). cles in rats. Toxicol Lett; 194(3):58- Propagation characteristics of the 65. IF: 3.479. Reviews and electrical impulse in the normal and obstructed ureter as deter- Editorials mined at high electrophysiological Nemmar A, Al-Salam S, Zia S, Yasin J, Al Husseni I, Ali BH. (2010). Die- Mantilla CB, Fahim MA, Sieck GC. resolution. BJU Int Nov, 2010. [in (2010). Functional Development press] sel exhaust particles in the lung aggravate experimental acute of Respiratory Muscles, Fetal and Neonatal Physiology [in press] Howarth FC, Jacobson M, Shafiul- renal failure. Toxicol Sci;13(1): 267- lah M, Ljubisavljevic M, Adeghate 77. IF: 4.814. E. (2010). Heart rate, body tem- perature and physical activity are Nemmar A, Melghit K, Al-Salam S, k variously affected during insulin Zia S, Dhanasekaran S, Attoub S, treatment in alloxan-induced Al-Amri I, Ali BH. (2010). Acute res- Published type 1 diabetic rat. Physiological piratory and systemic toxicity of Research (Epub ahead of print). pulmonary exposure to rutile Fe- Abstracts, doped TiO(2) nanorods,Toxicology. Letters and Howarth FC, Shafiullah M, Epub 2010 Nov 10. IF: 3.241. Adeghate E, Ljubisavljevic M, Correspondence Jacobson M. (2010). Heart rhythm O’Grady G, Du P, Egbuji JU, Mithra- disturbances in the neonatal ratne P, Lammers WJEP, Chen JDZ, Adrian TE, Gariballa S, Parekh KA, alloxan-induced diabetic rat. Patho- Cheng LK, Windsor JA, Pullan AJ. Thomas SA, Saadi H, Al Kaabi J, physiology (Epub ahead of print). (2010). High-resolution entrain- Nagelkerke N, Gedulin B, Young ment mapping of gastric pacing: AA. (2010). The Bile Acid Brake: A Novel Target for Treating Diabetes Howarth FC, Almugaddum FA, a new analytic tool. Am J Physiol Gastrointest Liver Physiol. 2010 and Obesity. Diabetes 59 (Supple- Qureshi MA, Ljubisavijevic M. ment 1) A164. (2010). The effects of heavy long- Jan; 298: G314-321.

83 Department of Physiology

Adrian TE, Gariballa S, Parekh KA, stomach: initial results. Neurogas- Hussien ZH, Qureshi ma, Howarth Thomas SA, Saadi H, Al Kaabi J, troenterol Motil 22: 11, 2010. FC. (2010). The chronic effects of Nagelkerke N, Gedulin BR, Young neonatal alloxan-induced diabetes AA. (2010). Can Diabetes be mellitus on ventricular myocyte treated through the rectum? shortening and intracellular Ca2+ Diabetologia 53 (Suppl 1) S44. k transport. Physiology 2010, Uni- versity of Manchester, UK, PC112, Al Shuaib WB, Hasan MY, Fahim P147-148. MA. (2010). Pottasium currents in Proceedings, wild-type and dunce drosophila Ljubisavljevic M, Cukic M, neurons. Neuroscience 40. Conferences, Filipovic S, and Ismail F. (2010) Invited Lectures, The effects of transcranial Egbuji JU, O’Grady G, Du P, Chen magnetic stimulation on elec- LK, Lammers WJEP, Windsor JA, Web Sites tromyographic characteristics in Pullan AJ. (2010). High resolution Primary writing tremor patients. mapping of regional variations and Others 14th International Conference of in porcine gastric slow wave Adrian TE. (2010). Project dis- Parkinson’s Disease and Move- activity. Gastroenterology 138/5, cussion: How to transform raw ment Disorders, Buenos Aires, S2073. data into a manuscript and a Argentina, Jun 13 to 17. ten minute talk. Pancreas 2000 Fahim MA, Karam S, al-Ramadi B. Conference, Fitzwilliam Collage, Marzouqi F, Al Dhaheri A, Zia S, (2010). Ghrelin enhances the re- Cambridge, England, September Dhanasekaran S, Kazzam EE, Al generative potential of stem cells. 18. Salam S, Nemmar A. (2010). As- FASEB J, 24: 1008. sessment of the acute pulmonary Ali, BH, Salam S, Nemmar A. and cardiovascular effects of Khan G, Rizvi TA, Blair I, Adrian (2010). The effect of diesel exhaust particulate air pollution. The 7th TE. (2010). Risk of blood-borne particles on cisplatin –induced International Scientific Confer- infections in barber shops. J Infect acute renal failure in rats. Present- ence for Medical Students in the Public Health. 3:88-9, Epub PMID: ed to the 2nd Pan-Arab Military GCC Countries, Jeddah, Saudi 20701897. Medicine, December, Jeddah, Arabia. Saudi Arabia. Lammers WJ, Al-Bloushi HM, Al- O’Grady G, Angeli T, Lahr C, Du P, Eisaei SA, Al-Dhaheri FA, Stephen Ali BH, Al Salam S, Alhusseni I, Cheng LK, Lammers WJ, Farrugia B, John R, Dhanasekaran S, Karam Nemmar A. (2010). Compara- G, Pullan AJ. (2010). High-resolu- SM. (2010). ICC and Slow Wave tive protective effect of N-acetyl tion mapping of slow wave activ- Propagation in the Small Intestine cysteine and tetramethailpyrazine ity in the gastroparetic stomach : of Diabetic Rats. Gastroenterology in rats with gentamicin nephro- initial results. Neurogastroenterol- 138/5, S2067. toxocity. Experimental Biology ogy & Motility Joint International Conference, April 24-28, 2010, Meeting, Boston. Lammers WJEP, Ver Donck L, Anaheim, California. Abstract Stephen B, Smets D, Schuurkes published in FASEB. Singh J, Howarth FC, Adeghate E, JAJ. (2010). Initiation and propa- D’Souza A. (2010), Morphological gation of secondary waves in the D’Souza A, Yanni J, Dobrynski H, changes in the hearts of diabetic canine stomach in vivo. Gastroen- Boyett M, Howarth FC, Singh J. rats, XX World Congress Interna- terology 138/5, W1937. (2010). Remodelling of the left tional Society Heart Research, ventricle in ageing type 2 diabetic Kyoto International Conference Nemmar A, Al-Dhaheri A, Mar- Goto-Kakizaki rats, XX World Con- Center, Kyoto, Japan, 71: P181. zouqi A, Zia S, Dhanasekaran S, gress International Society Heart Al-Salam S, Kazzam EE. (2010). Research, Kyoto International Acute cardiovascular effects of Conference Center, Kyoto, Japan, k pulmonary exposure to diesel 71: P292. exhaust particles: Protective ef- fect of thymoquinone. European Howarth FC, Ljubisavljevic M, RESEARCH GRANTS Respiratory Society Conference, Qureshi MA, Adeghate E, Shafiul- Barcelona, Spain, 18-22 Septem- lah M, Jacobson M. (2010). Heart FMHS Research Grants ber 2010. European Respiratory rhythm disturbances in two ex- Journal, No. 2543. perimental rat models of alloxan- Prof TE Adrian (PI), Dr Eric Mensah- induced diabetes, XX World Brown. O›Grady G, Angeli TR, Lahr C, Due Congress International Society Role of calpain 3 and other P, Cheng LK, Lammers WJ, Farrugia Heart Research, Kyoto Interna- apoptosis-related proteins in the G, Abell T, and Pullan AJ. (2010). tional Conference Center, Kyoto, changes preceding retinopathy in High-resolution mapping of slow Japan, 71: P353. diabetic rats. (NP/10/38). wave activity in the gastroparetic

84 Department of Physiology

Prof. E. Kazzam (PI), Dr I. Hassan, Dr dysfunction in the Zucker diabetic National Research Foundation A. Nemmar, Dr O. Trad fatty rat [2010-2011]. Grant Cardiac function in patients with thalasssemia major with special Drs A. Nemmar (PI), S. Al-Salam Prof Thomas E. Adrian (PI). emphasis on right ventricular and Prof. E. Kazzam Resolvins and protectins in cancer, remodelling and pulmonary hy- Mechanisms of adverse pulmo- 2010- 2011. pertension: relation to neurohor- nary and cardiovascular effects of mones and collagen markers. particulate air pollution Profs L Al-Gazali (PI), EA Adeghate, TE Adrian, BK Al-Ramadi, OM El- Prof WJEP Lammers (PI), Ms B Terry Fox Fund for Cancer Re- Agnaf and Dr. BR Ali. Stephen, Dr M Al Sultan. search Genes and Diseases Research Electrical activity in the pacemaker Center of Excellence. [2010-2015]. region of the pregnant guinea-pig Profs TE Adrian (PI), F Safi and Dr. uterus. P Collin. Dr S Shehab (PI) and Prof M. Ljubi- Effects and Mechanism of Frondo- savljevic (2010-2013) Prof Milos Ljubisavljevic (PI) side A, a Novel Anti-Cancer Agent. How does Deep Brain Stimulation Changes in nociception and pain [2009-2011]. work? in rotenone rat model of Parkin- son’s disease. Profs TE Adrian (PI), F Safi and Dr Profs M. Ljubisavljevic (PI), T P Collin Adrian and Dr S. Shehab Dr A. Nemmar (PI), Dr S. Al-Salam, Marine Mussel Oil for Cancer Treat- The mechanisms of Repetitive Dr Hammad. ment [2010-1013]. Transcranial Magnetic Stimula- Impact of particulate air pollution tion (rTMS) induced modulation on ischemic acute renal failure: Emirates Foundation Grant of brain plasticity in health and Possible protective effect of thy- disease (2010-2013) moquinone. Profs TE Adrian (PI), JFB Morrison, A Perrin and Dr. R Hennig. Profs M. Ljubisavljevic (PI), Dr S. UAEU Individual Grants The Expression of Genes in Shehab and Prof T Adrian Neurons and the Tissues they Improved Therapy for Brain Inju- Dr A. Nemmar (PI), Dr S. Al-Salam. Innervate During Development of ries. (2011) Grant 31M016. Time-course and mechanisms of Neuropathy in Two Animal Models pulmonary and extrapulmonary of Type 2 Diabetes and in Human toxicity of the systemically admin- Tissues [2010 -2012]. Others istered particulate air pollution in rats. Profs FC Howarth (PI), TE Adrian, Profs TE Adrian (PI), S Gariballa, H E Adeghate, Drs M Oz and Al- Saadi and Dr. J Al-Kaabi. UAEU Interdisciplinary Grants Minhali Release of Rectal Hormones for Progressive changes in expression Weight Loss and Improvement of Profs TE Adrian (PI), F Safi, J Per- of genes encoding Ca2+ signalling Type 2 Diabetes Mellitus. Satiogen mert and Dr. D Kelly. proteins and remodelling of Ca2+ Inc, San Diego, California, USA. Expression of Genes Predispos- proteins underlies cardiac muscle ing to Type 2 Diabetes in the UAE dysfunction in type 2 diabetic Awards [2008-2010]. heart. Prof Howarth received FMHS Prof MA Fahim (PI) Prof. E. Kazzam (PI), Dr I. Hassan Distinguished Research Award Ghrelin and recovery after antine- and Dr A. Nemmar. 2009-2010 oplastic and cytotoxic therapy. Cardiac remodeling and ven- tricular interaction in patients Department of Physiology re- Profs FC Howarth (PI), TE Adrian, with Thalassemia Major: Detailed ceived FMHS best teaching award Dr M Jacobson, Profs M Ljubisavi- Echocardiograific and Magnetic for 2010 jevic, E Adeghate Resonance Imaging Evaluation in Effects of exercise training on relation to Neurohormones and heart function in the Goto-Kakiza- Collagen markers. (2010-2012) ki type 2 diabetic rat [2010-2012] k Dr A. Nemmar (PI), Dr S. Al-Salam, Sheikh Hamdan Award for Profs. E. Kazzam and M. Lukic Medical Sciences Experimental studies on the interactions between pulmonary Prof C Howarth [PI], E Adeghate, TE exposure to particulate air pollu- Adrian, Drs M Jacobson, K Parekh, tion and hypertension: Pathophys- Mr A Qureshi iologic mechanisms and influence Remodeling of Ca2+ transport of protectant drugs proteins underlies cardiac muscle

85 Department of Physiology

2010Physiology

Standing left to right: Ms K Parekh, Mr Saeed, Professors FC Howarth, W Lammers, Dr A Nemmar, Professor M Ljubisavljevic, Mr S Dhanasekaran and Mr P Rajagopalan. Seated left to right: Ms SA Thomas, B Stephen, S Zia, Professors TE Adrian, M Fahim, Mr A Qureshi.

http://www.fmhs.uaeu.ac.ae/Departments/Physiology. Tel: 7672000 / Fax: 7671966

86 Department of Psychiatry and Behavioural Sciences

A. Departmental Profile and Research Themes: Professor and Chair: 1. Epidemiological aspects of common mental health disorders in Prof Omer El Rufaie primary health care and community settings Professor: Prof. Mohammad Reza (a) First-episode psychosis presenting at the psychiatric depart- Sadeghi ment of Al-Ain Hospital. (Dr. M.O. Salem). Associate Professors: Dr. Rafia Ghubash (b) A study of the prevalence, socio-demographic correlates and Dr. Ossama T. Osman co-morbidity of premenstrual dysphoric disorder in the primary Dr. Hamdy F. Moselhy care. (Dr. O. Osman). Dr. Mohamed Omar Salem Dr. Kanita Dervic (c) A 10-year Retrospective study of the prevalence and correlates Assistant Professor: of various psychiatric diagnoses among inpatient admissions to Dr. Leena Amiri Al-Ain Hospital. (Dr. O. Osman). Research Technician Mr Said Yousef (d) Suicidal behavior and suicide prevention in childhood and Ms. Fadwa Algid adulthood. (Dr. K. Dervic). Secretary Mr D. Ranganathan (e) Affective disorders in childhood and adulthood. (Dr. K. Dervic). Miss Aisha Al Shamsi Clerk II: (f ) Cross-cultural child and adolescent psychiatry (Dr. K. Dervic). Mr O. Pocker

(g) Affective and anxiety disorders in childhood and adolescence. (Dr. L. Amiri).

(h) Suicidal behaviour: An integrative approach. (Prof. M.R. Sadeghi)

(i) Effect of stress, depression, social support, and coping on psy- chological distress of patients with Ischemic heart disease. (Prof. M.R. Sadeghi).

(j) Prevalence of Teenager depression in Al Ain. (Prof. M.R. Sadeghi)

(k) Prevalence and correlates of suicidality in rural population of Pakistan. (Prof. M.R. Sadeghi).

(l) Life satisfaction among older adults in UAE. (Dr. H. Moselhy).

(m) The association of mental disorders with unhealthy behav- iours among adults in UAE (Dr. H. Moselhy).

87 Department of Psychiatry & Behavioural Sciences

2. Personality, psychosocial and 5. Psychotherapy trans-cultural aspects of physical illness Cognitive Behaviour Group Therapy (rCBGT) for (a) Association of Irritable Bowl Syndrome with Breast Cancer Patients with Psychiatric. Morbid- personality traits and with anxiety and depres- ity: Controlled Study- in collaboration with the sive disorders. (Prof. O. El Rufaie). Dept of psychiatry, Faculty of Medicine, Alexan- dria University. (Dr. M.O. Salem). (b) Psychological and social intervention in patients undergoing bariatric surgery. (Dr. O. 6. Women’s Mental Health Osman). (a) A study of Symptoms Expression of PMDD in Women in the Primary Care. (Dr. O. Osman). (c) Depressive disorders as a risk factor in susceptibility to coronary heart disease. (Dr. H. (b) Psychosocial study of pregnant women with Moselhy). foetal abnormalities. (Dr. O. Osman).

(d) Relation of brain lesion and apathy, depres- (c) A study of the post-partum psychiatric disor- sion, cognition and daily function in stroke ders in Al Ain. (Dr. O. Osman). patients. (Dr. H. Moselhy). (d) Maternal Anxiety and Depression Following a 3. Cultural aspects of psychiatry Diagnosis of Gestational Diabetes Mellitus (Prof. (a) Help seeking behaviour of psychiatric pa- M.R. Sadeghi). tients before attending the psychiatric services at Al-Ain Hospital. (Dr. M.O. Salem). 7. Postgraduate Education and Training (a) Arab Board Curricular development in psy- (b) Colour preference of patients attending the chiatry (Dr. O. Osman). psychiatric Department of Al-Ain Hospital. (Dr. M.O. Salem). (b) Survey of Arab Board programs for structural and procedural organizations (Dr. O. Osman). (c) Time estimation of patients with psychiatric morbidity attending Al-Ain Hospital. (Dr. M.O. 8. Recent translation, development and Salem). validation of psychiatric instruments for use among Arabic speaking population. (d) Cross-cultural child and adolescent psychia- t
.JOJ*OUFSOBUJPOBM
/FVSPQTZDIJBUSJD
*OUFSWJFX
try. (Dr. K. Dervic). (MINI) (Dr. O. Osman).

(e) Cultural Aspects of Trauma: A Joint partner- 9. Biological Psychiatric Research: Dr. H. ship research project with Harvard Program on Moselhy) Refugee Trauma (Dr. O. Osman). t
(SPVQ
*7"
QIPTQIPMJQBTF
"
"
QPUFOUJBM
marker for schizophrenia 4. Dream Research (a) Effect of Dreams on psychiatric patients t
.PMFDVMBS
HFOFUJD
TUVEZ
PG
TDIJ[PQISFOJB
JO
presenting at Al Ain Hospital psychiatric clinic. Arab population. (Dr. M.O. Salem). t
4UVEZ
PG
UIF
4FSPUPOJO
USBOTQPSUFS
HFOFT
QSP- (b) Significance of dreams among UAE Univer- moter varian (5-HTTLPR) in sity students. (Dr.M.O. Salem). depression and anxiety (Dr. O. Osman).

(c) Effect of watching movies on the viewer’s 10. Trauma Research (Dr. O. Osman) dreams in a sample of UAE university students. t
*OUFSQFSTPOBM
WJPMFODF
BNPOH
USBVNB
QBUJFOUT
(Dr. M.O. Salem). in Al-Ain.

(d) Religious and Spiritual Dream Symbols in t
4VCTUBODF
BCVTF
BNPOH
USBVNB
QBUJFOUT
GSPN
Two Samples: Canadians and the United Arab Al-Ain Registry. Emirates. (Dr. M O Salem).

88 Department of Psychiatry & Behavioural Sciences

Original articles Pac J Public Health, 22S; 48-53. Proceedings, in peer reviewed Salem MO. (2010). Function of Conferences, Dreams: An Integrated approach, journals The Journal of the Islamic Medical Invited Lectures, Association of North America Web Sites Ali Younis, Hamdy Moselhy. (2010). (JIMA) 42(1);15-22. Pattern of attempted suicide in and Others Babylon in the last 6 years of sanc- tion against Iraq. The International k Carballo JJ, Muñoz-Lorenzo L, Blas- Psychiatry Journal 7(1);18-19. co-Fontecilla H, Lopez-Castroman J, Perez-Rodriguez MM, Dervic K, Blasco-Fontecilla H, Baca-Garcia Books, Chapters, Oquendo, MA. (2010). Continu- E, Duberstein P, Perez-Rodriguez ity of Depressive Disorders from MM, Dervic K, Saiz-Ruiz J, Cour- Reviews and Childhood and Adolescence to tet P, de Leon J, Oquendo MA. Adulthood: A Naturalistic Study at (2010). An exploratory study of the Editorials Community Mental Health Centers relationship between diverse life Osman OT. (2010). The skin as a in Madrid, Spain., 163rd Annual events and personality disorders Meeting of American Psychiatric in a sample of suicide attempters. mode of communication. Expert Rev. Dermatol. 5(5); 493-496. Association (APA), New Orleans, Journal of Personality Disorders USA. 24(6); 773-784. (Editorial). Dervic K. (2010). Suicide in Child- Elmahdy M, Elsayed O, Elgamal hood: An international perspec- R, Shahda M, Moselhy H. (2010). k tive. International Symposium of Family profile of heroin users in the Wiener Werkstaette for Suicide Mansoura, Egypt. Addictive disor- Research, 9 October, Vienna, ders and their treatment Journal 9 Published Austria (3);117-122. Abstracts, Dervic K. (2010). Epidemiology Fajkic A, Lepara O, Voracek M, Letters and and Clinical Characteristics of De- Kapusta ND, Niederkrotenthaler Correspondence pression and Suicidality in Child- T, Amiri L, Sonneck G, Dervic K. hood and Adolescence. Jubilee (2010). Child and adolescent sui- Dervic K, Fajkic A, Lepara O, Conference: 35 Years of Viennese cides in Bosnia and Herzegovina Voracek M, Kapusta N, Nieder- Child Psychiatry, 24.-25. Septem- before and after the war (1992- krotenthaler T, Amiri L, Sonneck ber, Medical University of Vienna, 1995). Crisis 31(3);160-4. G. (2010). Youth suicide in Bosnia Vienna, Austria and Herzegovina. Chinese Medical Gubash R, El Rufaie O, Zubaidi T, Journal, Vol. 123, Supplement 2, Dervic K. (2010). Assessment Sufian Sabri, Yousef S, Moselhy May 28, p.188. and Management of Suicidality H. (2010). Subjective life satisfac- in Childhood and Adolescence tion and mental disorder in old Dervic K, Al Hallami A, Al Mazrouei (Workshop). Jubilee Conference: age people in UAE. International A. (2010). Child and adolescent 35 Years of Viennese Child Psy- Journal of Geriatric Psychiatry.25; psychiatric services in United Arab chiatry, 24.-25 September, Medical 458-465. Emirates. Chinese Medical Journal, University of Vienna, Vienna, Vol. 123, Supplement 2, May 28, Austria Kapusta ND, Voracek M, Niederkro- p.159. tenthaler T, Dervic K, Etzersdorfer Dervic K. (2010). Religious affilia- E, Plener PL, Schneider E, Stein C, Salem MO, DeCicco TL, Latif tion: A protective factor against Sonneck G. (2010). Characteristics MA, Yousif S, Murkar A. (2010). suicidal behavior? 11th Pan-Arab of Police Officer Suicides in the Religious and Spiritual Dream Psychiatric Conference, Khartoum, Federal Austrian Police Corps. Symbols in Two Samples: Canadi- Sudan. Crisis 31(5); 265-71. ans and The United Arab Emirates. International Journal of Dream Dervic K, Lenz G, Friedrich MH. Moselhy H, Ehsan Fahmy, Victor Research, Vol 3, Suppl 1; S8-9. (2010). Residency research Samy, Hussain El Shiekh. (2010.) training in child and adolescent Impact of life events on the profile Salem MO, Salem OM, Yousef S. psychiatry. Annual Meeting of the of opiate dependence syndrome. (2010). Effects of Watching Films Association for Study of Medical American Journal of Drug and on Dreams of the UAE University Education (ASME), Cambridge, Alcohol Abuse 36; 7-12. Students. International Journal of United Kingdom. Dream Research, Vol 3, Suppl 1; S9. Osman OT, Afifi (2010). Mental Dervic K, Al Hallami A, Al Mazrouei health research in the United Arab A. (2010). A survey of child and Emirates from 1989 to 2008. Asia k

89 Department of Psychiatry & Behavioural Sciences

adolescent psychiatric services Recovery. Orvieto-Italy, Nov 9, UAE University, Al Ain. in United Arab Emirates. The 1st entitled: Mastery in Global Mental International Conference For Psy- Health: Trauma and Recovery. Salem MO, Salem OM. Yousef S. chological Sciences And Applica- (2010). Effects of Watching Films tions, Al Ain, UAE. Osman OT. (2010). Excellence in on Dreams of the UAE University Global Mental Health- keynote Students. 27th Annual Conference Dervic K. (2010). Suicide and sui- presentation invited by The Behav- for the International Association cide prevention among children: ioral Sciences Pavilion (Formerly of the Study of Dreams, Chicago, An international perspective.The Abu Dhabi Psychiatric Hospital) at USA . 1st International Conference For Sheikh Khalifa Medical City- Event: Psychological Sciences And Ap- World Mental Health Day Scientific Salem MO, DeCicco TL, Latif plications, Al Ain, UAE. Program, Abu Dhabi. MA, Yousif S, Murkar A. (2010). Religious and Spiritual Dream Moselhy HF. (2010). Association of Osman OT. (2010). The invisible Symbols in Two Samples. Canadi- life satisfaction and mental disor- injuries of war and disaster: 6th ans and The United Arab Emirates. ders of older adults in UAE. World Middle East Trauma, Accident and 27th Annual Conference of the Psychiatric Association, Beijing, Emergency (A&E) Conference, Abu International Association for the China. Dhabi. Study of Dreams, Chicago, USA. Moselhy HF.(2010). Impact of self Osman OT. (2010). Symptoms reported life events on the profile expression of and correlates of Salem MO. (2010). Workshop on of opioid dependence syndrome. Premenstrual Dysphoric Disorder Integrating Spiritual Techniques World Psychiatric Association in Al-Ain region. Al-Ain Hospital/ into Psychotherapy – Islamic (WPA International Congress) Medical University of Vienna CME Model. Proceedings of the 1st Beijing, China. research presentation, Al-Ain. International Conference of Saudi Psychiatric Association, Al Khobar, Moselhy HF.(2010). Creativity Sadeghi MR. (2010). Progressive Saudi Arabia. dissociation and suicide. 11th Muscle Relaxation Training for pan Arab Psychiatric congress. psychologist. 4th World Congress Salem MO. (2010). Workshop on Khartoum. of the A.P.P.A.C. Association of Psy- Dream Interpretation in Science chology and Psychiatry for Adults and Religion. Proceedings of the Osman OT. (2010). Development and Children, Athens, Greece. 11th Pan Arab Psychiatric Con- and Evaluation of the First Struc- gress, Khartoum, Sudan. tured UAE Psychiatric Residency Sadeghi MR. (2010). Cognitive- Training Program. First Interna- Salem MO, Hamdan AL. (2010). Behavior Therapy for Depression. Spiritual and Religious interven- tional Conference on Medical Edu- Iranian Psychological Association cation (ICME 2010), Abu Dhabi.. tions in Psychiatry and Psycho- series of workshops, September 8 therapy. 1st International Confer- and 9, Tehran, Iran. Osman OT. (2010). Psychiatric Re- ence on Psychological Sciences and Applications. Al Ain, UAE. search In the United Arab Emirates Sadeghi MR. (2010). Sui- 1989-2009 . International Confer- cidal behavior: An integrative ence on Global Health, Al-Ain. Salem MO. (2010). Integrating approach.1st International Confer- Spiritual Techniques into Psy- ence on Psychological Sciences Osman OT. (2010). Psycho-derma- chotherapy – Islamic Model. 1st and Applications, UAE University, International Conference of Saudi tologic Disorders: Skin as a mode Al Ain, UAE. of Communication. 10th annual Psychiatric Association, Al Khobar, Saudi Arabia. Dubai Derma international Confer- Sadeghi MR. (2010). Integrating ence, Dubai. Mental Health into Primary Health Salem MO. (2010). Dream Inter- Care. Invited contribution at 4th pretation in Science and Religion. Osman OT. (2010). Descriptive World Congress of the A.P.P.A.C.: Proceedings of the 11th Pan Arab Outcome of the First Psychiatry Association of psychology and Psychiatric Congress, Khartoum, Residency Training Program in the psychiatry for adults and Children, Sudan. United Arab Emirates. The Ottawa Athens, Greece. International Conference on Medi- Yousef S, Adem A, Eapen V, cal Education, Miami, Florida. Sadeghi MR (2010). Progres- Zoubeidi T, Kosanovic M, Mab- sive muscle relaxation training rouk AA, Souid AK. (2010). Impact Osman OT. (2010). Mastery of Glo- for medical students. The 7th of Heavy Metals on Childhood bal Mental Health and Psychiatric Scientific Conference for Medical Behaviors and Development: A Reasearch in the Gulf. Harvard Students in the GCC countries UAE Study. Globalization and University Program on Refugee Public Heath Conference, Beirut- and Trauma as part of their Har- Salem MO. (2010). Precognitive Lebanon. vard University -HPRT Advanced Dreams in science and Religion. Certificate Training in Trauma & The Arabic Literature Dept. of the

90 Department of Psychiatry & Behavioural Sciences

Yousef S, Adem A, Eapen V, Others Zoubeidi T, Kosanovic M, Mabrouk AA, Souid AK. (2010). Blood con- UAEU Global Health Institute centration of Heavy Metals and its Grant association with Behaviors of UAE Dr O.Osman (Co-PI) children. 11th Pan Arab Psychiatric Building Capacity and Partnership Congress- Mental Health services For Excellence in Mental Health: A in the Arab World (Challenges and joint Collaboration Between UAEU Prospects), Khartoum – Sudan. and Harvard Medical School- HRTP

UK, Aberdeen Research Group k Dr H Moselhy Group IVA phospholipase A2: A potential marker for schizophre- RESEARCH GRANTS nia: UAEU Individual Research Grant k Dr O Osman (PI) Psychiatric Morbidity and Cor- relates of Mental Health Problems Among Bariatric Surgery Patients.

2010Psychiatry http://www.fmhs.uaeu.ac.ae/Departments/Psychiatry Tel: 7672000 / Fax: 7672995

91 Department of Radiology

Research Profile

Professor & Chair: Our research interests are focussed on Prof P Corr common medical and health issues in the UAE. Professor: Prof R Langer Associate Professor: Sports Medicine Imaging Dr K V Gorkom We continue our interest in injuries sustained by sportsmen espe- Teaching Assistant cially long distance runners and soccer players. We are currently Dr T Al Mansour investigating changes in Hoffa’s fat pad in the knee joint follow- Administrative Assistant: ing trauma and osteoarthrosis of the knee. Ms R Qayed Contrast medium research We are active in this area of radiology. Two studies were per- formed during the year: An in vitro study of the efficiency of adding antibiotics to non-ionic contrast media for intradiscal [UAEU grant 2008/ completed]; collaboration with the FMHS De- partment of Pharmacology, and international collaboration with ‘Experimental Radiology’, Charité University, Berlin / Germany and an investigation of the development of NSF after IP admin- istration of various GBCA [FMHS grant 2008/ animal experiments ongoing]; collaboration with the FMHS Departments of Pharma- cology, Anatomy, and international collaboration with ‘Experi- mental Radiology’, Charité University, Berlin / Germany

Renal Calculi Analysis using Dual Source Computed Tomography We are currently investigating the usefulness of dual source CT in the detection of renal calculi of different composition in patients presenting with renal calculous disease at Al Ain Hospital with colleagues from Chemical pathology and physicians from Al Ain Hospital.

Investigation of Pharmaceutical and Herbal Agents that pre- vent the Pathogenesis of Hepatic Fibrosis and Liver Cancer in an Animal Model. This work, with colleagues in Molecular Biology and Medical Physics, involves the identification of herbal agents that may used to prevent the development of hepatic fibrosis and the progression of liver cancer in a rat model. Saffron herb used in cooking, has been found to have therapeutic effects preventing the development and progression of liver cancer within an animal model. Imaging of the microstructure of the

92 Department of Radiology liver is being performed using magnetic resonance imaging Articles in Peer- and the data processed with textural analysis. reviewed Journals Development of Nanoparticle Contrast Agents that de- Ali BR, Xu H, Akawi NA, John A, Karu- tect Cancer Angiogenesis vantevida NS, Langer R, Al-Gazali L, We are investigating with researchers from the Faculty of Leitinger B. (2010). Trafficking de- Engineering’s Centre for Nanotechnology rare earth gadolin- fects and loss of ligand binding are ium and iron nanoparticles for the detection of new blood the underlying causes of all reported DDR2 missense mutations found in vessels in cancers of the liver, breast and colon. These tagged SMED-SL patients. Human Molecu- nanoparticles can be detected by magnetic resonance imag- lar Genetics 2010 Jun1;19(11):2239- ing and may be useful in targeted therapy and monitoring 50, Epub2010 Mar 10. clinical treatment response of these cancers clinically. We are currently investigating intracellular and extracellular recep- tor sites for tagged nanoparticles in cancer cells. k

Thalassemia Published Thalassemia is one of the commonest inherited disorders Abstracts, affecting one in five residents and nationals of the UAE. With the researchers from Internal Medicine we have measured Letters and the quantity of iron deposited in the hearts of thalassemic Correspondence patients attending Tawam Hospital using cardiac magnetic resonance imaging. This is an important marker of iron Langer RD, Lorke DE, Neidl van Gorkom KFW, Petroianu G, Azimul- deposition as iron toxicity is a major cause of heart disease lah S, Nurulain SM, Speck U. (2010). in thalassemic patients. Chelating drugs are now available to Nephrogenic systemic fibrosis remove the excess iron and prevent this heart complication cannot be induced by administer- from occurring. ing Gadolinium bound contrast agents in rats. European Congress of Radiology [ECR] Vienna, Austria, Neuroimaging March 4-8/C-1138 Neuroimaging plays a key role in analysis, diagnosis and treatment of diseases of the central nervous system. Langer RD, Neidl van Gorkom Magnetic Resonance Imaging is the tool of choice for the KFW, Usmani A, Petroianu G, Lorke examination of the CNS in vivo without ionization radiation. DE, Baniyas MYH, Azimullah S, Nurulain SM. (2010). In vitro as- Computed assisted evaluation. In allows for morphometric, sessment of potential interactions fine-structural as well as for functional examinations. We are between radio contrast media and working at the implementation of sophisticated software antibiotics and their impact on (FSL & FreeSurfer) and adaptation to local needs and testing discography. European Congress with normative external data-sets is the first step of this of Radiology [ECR] Vienna, Austria, March 4-8/C-1129 project. In a second step a small number of dedicated local MRI examinations (Tawam, Al Ain Hospitals) will be evalu- Langer RD, Lorke DE, Neidl van ated. Gorkom KFW, Petroianu G, Azimul- lah S, Nurulain SM, SpeckU. (2010). Rats do not develop nephrogenic These efforts are also related to the upcoming projects in the systemic fibrosis after intraperito- field of cognitive sciences at the main university. neal administration of Gadolinium bound contrast agents. AJR 2010; 194 (5/Suppl), A 315

Langer RD, Neidl v Gorkom K, Usmani A, Lorke DE, Petroianu G, Banyias MYH, Azimullah S, Nurulain SM. (2010). Potential in- teractions between radio contrast media and antibiotics and their possible impact on discography - an in vitro study. AJR 2010; 194 (5/ Suppl), A 687

93 Department of Radiology

Langer RD, Lorke DE, Neidl nisms underlying Sponydylo-me- van Gorkom KFW, Petroianu G, ta-epiphyseal dysplasia with short RESEARCH GRANTS Azimullah S, Nurulain SM, Speck limbs and abnormal calcifications FMHS Research Grants U. (2010). Rats do not develop (SMED-SL). 3rd Pan Arab Genetics nephrogenic systemic fibrosis Conference, Dubai 13.–14. 03.2010 Prof P Corr (PI) after intraperitoneal administra- Investigation of integrin receptor tion of Gadolinium bound contrast Amin A, Mahmoud Ghoneim D, imaging of cancer cell using RGD agents. Fortschr Roentgenstr Corr P. (2010). Saffron protects tagged nanoparticles. (NP 10/13) 2010, 182(S 1), S306 against liver cancer in animal model: Molecular and imaging UAEU Individual Grant insights. 50th Annual Meeting of k the American Society for Cell Biol- Prof RD Langer (PI), Drs K F W Neidl ogy in Philadelphia, PA, December van Gorkom, M Fuchsjaeger, D 11-15. Muslih, S Joshi Proceedings, Dual energy CT (DECT) for non- Conferences, Amin A, Mahmoud Ghoneim D, invasive differentiation between Corr P. (2010). Preventive poten- renal tract stones composed of Invited Lectures, tial of local herbs against drug uric acid and non-uric acid calculi. Web Sites induced-liver fibrosis: Promising future for noninvasive MRI-based Dr K Neidl v Gorkom, Prof RD and Others texture analyses Abu Dhabi Langer Genomics and Systems Biology Determination of Gadolinium in Ali BR, Xu HF, Akawi NA, John A, Meeting January. the skin after long term adminis- Karuvantevida NS, Langer R, Al- tration of high dose Gadolinium Gazali L, Leitinger B. (2010). Traf- Corr P. (2010). Asian Musculoskel- contrast medium in rats ficking defects and loss of ligand etal Society Annual Scientific binding are the underlying causes Meeting February 2010 Muscat Emirates Foundation Grant of all reported DDR2 missense Oman Invited Lecture: Imaging mutations found in Spondylo-me- bone contusions in sports related Drs A Amin (PI), D Mahmoud ta-epiphyseal dysplasia with short knee injuries with diffusion MR Ghoneim, Prof P Corr limbs and abnormal calcifications Evaluation of the saffron-based [SMED-SL] patients. British Society Corr P. (2010). International Soci- chemoprevention against liver for Matrix Biology Meeting,UK, ety of Gastrointestinal Radiology cancer: A novel approach utilizing 2010 Meeting August 2010 Cape Town, computed tomography as assess- S Africa: CT Signs of Small Bowel ment tool. Ali BR, Xu HF, Akawi NA, John Wall Thickening A, Karuvantevida NS, Langer R, k Leitinger B, Al-Gazali L. (2010). The k cellular and biochemical mecha- 2010Radiology

Left to right: T Al Mansour, Dr KVan Gorkom, R Qayed, Prof R Langer, Prof P Corr (Chair)

http://www.fmhs.uaeu.ac.ae/Departments/Radiology. Tel: 7672000 / Fax: 76722067

94 Department of Surgery

Research Profile

Faculty members in the Department have now Professor & Chair: increased from four (1999) to ten currently, Prof FJ Branicki Professor: five of whom are UAE nationals, with five Prof F Safi previously advertised senior positions Prof F Abu-Zidan (breast/endocrine surgery, minimal access Associate Professor: Dr F Torab surgery, neurosurgery, orthopaedics and Dr F Hammad otorhinolaryngology) yet to be filled. Faculty Assistant Professor: members have Consultant privileges at Al Ain Dr A Al Belooshi Dr A Jawas Hospital , Tawam Hospital or both institutions. Dr S Al Thani Dr T Al Mahmoud Dr Z Al Fardan Teaching Assistant: Professor Frank Branicki Dr MA Al Ali Prof. Branicki’s clinical interests include the management of Research Support: gastrointestinal bleeding, peptic ulcer and benign and malignant Mr L Lubbad gastroduodenal disease in particular as well as acute care surgery Ms M Al Mansouri and trauma management. Principal practice is in the manage- Administrative Support: ment of oesophago-gastric cancers. His role as Course Director Ms R Al Mansouri for Advanced Trauma Life Support (ATLS) with involvement in Mr A C Jamal Advanced Trauma Care for Nurses (ATCN) courses has led to Mr C Aboobacker generation of data for presentation and publication. These activi- ties led to presentations in 2010 in Al Ain, Abu Dhabi, Dubai and Kampala (Uganda). Collaboration with Assoc Prof Fawaz Torab led to a publication relating to laparoscopy for gastric tumours. In addition, collaboration with Prof. Sherif Karam has involved experimental studies relating to gastric cancer conducted by a co-supervised Master’s student, now awarded, under supervi- sion in Prof Karam’s laboratory. This work, funded by a research grant from the Terry Fox Foundation, has been productive and a publication is in press. Prof Branicki is Emeritus Editor of the indexed Asian Journal of Surgery and regularly reviews articles for the World Journal of Surgery, the European Journal of Surgical Oncology, etc. He also serves as the Chair of the Undergraduate Curriculum Policy and Review Committee. In June 2010 he was the recipient of the Distinguished Performance Award in the Fac- ulty of Medicine and Health Sciences (FMHS) at UAE University.

95 Department of Surgery

Professor Farouk Safi Conference: Trauma Management, Critical Care Prof. Farouk Safi’s clinical interests in surgical and Prevention which is scheduled for February oncology in particular have generated mate- 2011, in Al Ain, Prof. Branicki being the Chair of rial for presentations at national and overseas the Scientific Committee (Trauma). meetings. His contributions have included the management of severe liver injuries, hepato- Professor Abu-Zidan’s research activities in cellular carcinoma and pancreatic carcinoma occupational injury and road traffic collisions with lectures in Al Ain, Dubai, Vienna (Austria) attracted a good deal of media attention in 2010 and Aleppo (Syria). Currently, Prof Safi’s clinical with major coverage of the need for trauma pre- practice has generated data relating to surgical vention in the UAE. He continued his scholarship interventions for hepatic, pancreatic malignancy activities being a Guest Editor for a symposium and colorectal resections. on emergency sonography for the Journal of Emergencies Trauma and Shock. Professor Fikri Abu Zidan In 2010 Professor Fikri Abu-Zidan continued Associate Professor Fayez Hammad his focused research activities in the areas of Assoc Prof. Fayez Hammad has particular clinical trauma management, ‘point-of-care’ critical interests in minimally invasive surgery for renal care ultrasound and acute care surgery. He is stone disease and oncology in particular. He is effectively leading the Trauma Research Group the Founding Program Director for our recently of the FMHS with collaborative work involving established Residency training program in the Departments of Community Medicine and Urology. Assoc Prof. Fayez Hammad completed Radiology (FMHS), and Departments of Surgery, a study of “The effect of NSAIDs (non-steroidal Critical Care, Emergency Medicine and Radiol- anti-inflammatory drugs) on the obstructed kid- ogy at both Tawam and Al Ain Hospitals. In 2010, ney” funded by a Seed Grant from FMHS, United he published 13 articles/reviews in international Arab Emirates University. The study commenced refereed Journals. At present he is studying in late 2008 and by the end of 2009 work in two seatbelt injuries, bicycle and motorcycle related groups of animals had been completed (control injuries, camel related injuries, and point-of- group (left ureteric obstruction for two days) care emergency abdominal ultrasound. He has and an NSAIDs group (left ureteric obstruction been able to raise external funds to appoint a for two days having received NSAIDs), data were Research Fellow (Dr Alaa Abbas) and a Senior published in Urological Research. Research Fellow (Dr Ashraf Hefny). Dr Hammad also continued his work on “Spatial Professor Abu-Zidan was the Local Chair of the and temporal electrical impulse propagation Disaster Management and Crisis Response Mid- in the normal and the obstructed ureter” in dle East Conference 2010 that was held in Abu collaboration with Prof. Wim Lammers from Dhabi (May), Chair of the Organizing Commit- the Department of Physiology, FMHS. The early tee of the 6th Middle East Trauma, in Accident phase of this project was completed in 2009 and Emergency Conference also in 2010 in and has resulted in two publications (Journal Abu Dhabi (October), and the Co-Chair of the of Urology and the British Journal of Urology – Organizing Committee of the 2nd International International). The research was funded by an

96 Department of Surgery

Individual Research Grant from the United Arab stone fragmentation by Shockwave Lithotripsy: Emirates University (2008). An in vitro study” (Journal of Endourology). In After receiving the required devices in late 2009 collaboration with Dr Jawas and Prof Abu Zidan, a model was developed for the project “The Dr Hammad has reported findings concerning effect of gradual restoration of blood flow on “Vascular injuries following road traffic collisions ischemia-reperfusion injury in the rat kidney”. in a high-income developing country: a pro- This work was supported by a research grant spective cohort study” accepted for publication from the FMHS. Work has now been completed in the World J Emerg Surg. by Assoc Prof. Hammad and his co-investigator, Mr Loay Lubbad, Laboratory Manager on a new Associate Professor Fawaz Torab project “The effect of curcumin on the ob- Associate Professor Fawaz Torab is the Chair structed kidney in the rat”. The study has been of the Al Ain Medical District (AAMD) Human accepted for publication in European Surgical Research Ethics Committee. This Committee in- Research. Work on the effect of curcumin on cludes members from Tawam and Al Ain Hospi- ischemia reperfusion injury in the rat com- tals in addition to Primary Health Care, Preven- menced in 2010 and is ongoing as are studies of tive Medicine, Zayed Military Hospital and Oasis the ‘Regional distribution of spontaneous elec- Hospital. All research projects performed by trical activities in the isolated guinea-pig urinary human investigators or in a Health institution in bladder’. The manuscript has now been submit- AAMD are reviewed and approved by this Com- ted for publication. In collaboration with Dr Has- mittee. A submission seeking renewal of accept- an Elbiss, Department of Obstetrics and Gynae- ance with the Federal Wide Assurance authori- cology, Dr Hammad is participating in a study ties in USA was successful. This will facilitate any related to the incidence of urinary incontinence research project carried out in collaboration and prolapse in UAE women. In collaboration with researchers in the USA. with Prof Abu Zidan, Dr Hammad has published data regarding the incidence of genitor-urinary Promoted to Associate Professor Dr Torab is injuries among general trauma patients and in the ‘Founder’ and ‘President’ of the Obesity and road traffic collisions (Turkish Journal of Trauma Metabolic Surgery Interest Group in the UAE & Emergency Surgery). In collaboration with the (OMSIG). This group was accredited in 2009 Urology team from Dubai Hospital, Dr Hammad through the International Federation of Obesity has continued his research activities a) “The role Surgery (IFSO) and the UAE has now become a of urologists in the management of urological member of this prestigious federation. He has injuries during obstetric and gynaecologic sur- been a member of the Technical and Scientific gery” (Int Urogynecol J Pelvic Floor Dysfunct), b) Committee of the Roadways, Transportation “the Development and validation of an Arabic and Traffic Safety Research Centre, UAE Univer- version of the International Prostate Symptom sity since 2005, and of the National Committee Score” (British Journal of Urology International), on Research Ethics, Ministry of Health, since c) “The effect of fat and non-fat components 2008. Assoc Prof Torab was also nominated for of the skin-to-stone distance on Shockwave membership of the National Research Commit- Lithotripsy success” (Journal of Endourology) tee of the UAE. and d) “The effect of fat, muscle and kidney on

97 Department of Surgery

Assoc Prof Fawaz Torab’s clinical interests are in investigation of pro-inflammatory mediators in acute care surgery, particularly pancreatitis and patients undergoing open or laparoscopic sur- abdominal sepsis. There is a principal interest in gery for perforated peptic ulcer. In 2010, he has laparoscopic procedures (bariatric surgery) for made significant contributions with presenta- morbidly obese patients, whose co-morbidities tions nationally in Al Ain, Abu Dhabi and Dubai affecting life style and life span can be amelio- and internationally in Syria and Iran. rated by surgical intervention. A prospectively collected large database relating to surgical Assistant Professor Ali Jawas procedures performed is accruing and Assoc Assistant Professor Ali Jawas successfully Prof Torab has pioneered, in the UAE, the use of completed Residency training in General and single incision laparoscopic surgery (SILS) for Vascular Surgery at the University of Toronto in various procedures. 2004 and was appointed Assistant Professor in December 2004. Following his training in Vascu- lar Surgery he has also completed a Fellowship in Toronto and rejoined us in Al Ain in October 2005. He is actively involved in the provision of vascular services in both Al Ain and Tawam Hos- pitals. Since 2008 he has been Program Director for our Integrated General Surgery Residency Training Program and was appointed by the Arab Board for Medical Specialization, Damas- cus, Syria as their representative for General Surgery training in the United Arab Emirates. He has been a member of the evaluation Commit- tee for surgical training programs in different emirates. Main research interests are related to the study of the management of peripheral arte- rial disease in Gulf countries. An Executive Board member in the Vascular Society he contributed to writing the “Guidelines for the Management of Peripheral Arterial Disease in the GCC coun- tries”. In addition he is involved with studies of vascular trauma epidemiology and its manage- ment in the UAE, data were presented at meet- ings in Turkey, Qatar and in the UAE. Dr Jawas is much involved as Coordinator and Chair of the Scientific Committee for the 5th Conference of the Gulf Vascular Society and the 5th Scientific Meeting of the Saudi Society for Vascular sur- gery, to be held in March 2011.

Assistant Professor Tahra AlMahmoud Assistant Professor Tahra AlMahmoud com- He has also continued oversight of basic and pleted Residency training in Ophthalmology advanced laparoscopic surgical workshops and at McGill University, Montreal and a Fellowship courses in the UAE and elsewhere for Residents period in Ottawa concerned with disease of the in training and more experienced surgeons. anterior chamber of the eye. Appointed Assist- Research interests in collaboration with depart- ant Professor, Dr. Tahra returned to Al Ain in mental, basic sciences and hospital colleagues 2006 and is now practising at Al Ain and Tawam at Al Ain and Tawam Hospital include clinical Hospitals. Dr. AlMahmoud’s main research activi- outcomes of primary and revisional bariatric ties are in the area of Ophthalmology. Together surgery and single port procedures, experimen- with colleagues in Canada, she is involved in tal models of peritoneal sepsis, experimental collaborative clinical research comparing clini- studies of treatment of breast cancer, and the cal outcomes of various refractive procedures

98 Department of Surgery

such as Advanced Corneal Surface Ablation in August 2008 and is actively participating and Femtosecond Thin-Flap LASIK. In addition, in clinical services at Tawam Hospital. Dr Al- Dr AlMahmoud is performing, in collabora- Fardan’s main research areas are wound healing tion with Prof. M Lukic at FMHS, experimental and clinical outcome of reconstructive surgery. studies with an animal model of Experimental His principal clinical interests are in breast Autoimmune Uveitis in Galactin-3 Knockout reconstructive surgery and hand surgery. Dr Mice. Currently she is completing a fellowship in Al-Fardan is a co-founder and academic officer Uveitis in Montreal. for the ‘Hand Surgery Club, UAE’ and co-founder of the ‘Abu Dhabi Plastic Surgery Club’. He is also Assistant Professor Saeed Al Thani an active faculty member of AO-trauma Middle Assistant Professor Saeed Al Thani completed East which conducts hand surgery workshops Residency Training in Orthopaedics at the countrywide, and he is an active member of University of Toronto and was appointed Assist- the Canadian Society of Plastic Surgery. Dr ant Professor in July 2004. Following Fellow- Al-Fardan has also conducted workshops for ship training in ‘sports injuries, hand and joint injectable fillers in the GCC countries. replacement surgery’ at the same institution in Toronto he rejoined the Faculty in Al Ain in Dr. Mohamad Al Ali January 2006 and has been able to establish a Dr. Mohamad Al Ali, the most recently ap- busy Sports Injuries clinic and surgical practice pointed Teaching Assistant in the Department, in Tawam Hospital. undertook a short term period of training in Toronto for three months in 2007 and has com- Dr Al Thani is Vice President of the AO UAE menced Residency training in Otorhinolaryn- Alumni, Vice President of the National Sports gology at the Sahlgrenasks University Hospital, Medicine Committee and currently is President Sweden. of the Al Ain Orthopaedic Club. A senior medical laboratory specialist, Mr Loay Assistant Professor Ali Abbas Al Beloushi Lubbad took up appointment in the Depart- Assistant Professor Ali Al Belooshi completed ment in May 2008 and is much involved, in his Residency training in Toronto (Orthopaedic particular, with experimental studies of smooth Surgery) and having been appointed as an muscle function conducted by Dr. Fayez Ham- Assistant Professor, he undertook an extended mad. Ms. Mahra Al Mansouri is a General Techni- period of subspecialty Fellowship training in cian and assists with other duties relating to lower limb arthoplasty including revisional sur- teaching as well as research. Mr. Abdulla Jamal gery and is actively participating in elective and has been working for some years as Depart- emergency clinical services at Tawam Hospital. mental Secretary and, facilitates both teaching In 2009 he took on the role of Coordinator for activities in the Clerkships, workshops and vari- the Junior Surgical Clerkship. A number of pres- ous CME activities with dedicated service to a entations (oral and poster) were made regard- high standard, with assistance from Mr. Aboo- ing hip arthroplasty in Al Ain, Dubai and in the backer in office duties. Ms Raisa Al Mansouri USA. Dr Al Beloushi also serves as an Instructor joined the Department as Secretary in May for an AO Course for Orthopedic Trauma man- 2008 following secretarial duties in the Depart- agement. He is currently enrolled in an MBA ment of Mathematics at the UAE University and program with a focus in health sector manage- is now taking on more departmental adminis- ment (Duke University, USA). He is also the Chair trative responsibilities. Ms Mansouri is actively of the Malpractice Committee in Orthopedic engaged with administrative arrangements for Surgery for the Dubai Health Care Authority. teaching and CME activity, and this included the highly successful Trauma, Critical Care and Assistant Professor Zuhair Al Fardan Injury Prevention Conference which took place Assistant Professor Zuhair Al-Fardan completed in February 2009. Residency training in Plastic and Reconstruction Surgery in Toronto, and subsequently Breast Skills and Procedural Training Reconstruction Fellowship training including In April 2004 the Department hosted inaugural experience in microvascular surgery. Appointed back to back Provider and Instructor courses Assistant Professor he returned to the Faculty in the UAE for the Advanced Trauma Life

99 Department of Surgery

Support (ATLS). Four invited Faculty and staff from the Original Peer-Re- USA and one from Canada participated in the teaching and Provider courses have since been held again in the viewed Scientific Faculty and in Fujairah. These courses are training Emirati Articles graduates and others in trauma care and will help reduce the burden of disabling illness and mortality from motor Abu-Zidan FM, Elzubeir MA. vehicle crashes. In March 2008 the FMHS was the site for (2010). An interactive problem- solving approach to teach trauma- inauguration of the Advanced Trauma Provider Course for tology for medical students. World Nurses (ATCN) in the UAE. J Emerg Surg,13;5:24.

These activities run in concert with ATLS courses are Abu-Zidan FM, Hefny AF, made possible with the enthusiastic participation of Saadeldinn YA, El-Ashaal YI. (2010). Sonographic findings of superior Instructors from Tawam Hospital. In 2010 the Department mesenteric artery syndrome caus- hosted five ATLS and three ATCN courses in Al Ain and ing massive gastric dilatation in a members also participated as Instructors in courses held young healthy girl. Singapore Med in Fujairah. J, 51(11):e184-6. With the support of Faculty Administration it has been Bernieh B, Al Hakim MR, Boobes possible to establish a Clinical Skills and Procedural Train- Y, Abu Zidan FM. (2010). Fasting ing Centre which is a multidisciplinary venture to foster in Ramadan in chronic kidney training for undergraduates and particularly Residents in disease patients: clinical and bio- a variety of clinical disciplines. Dr. Fawaz Torab, who re- chemical effects. Saudi J Kidney ceived the Faculty Award for Teaching in April 2007, is the Dis Transpl, 21(5):898-902. Director of the Center with basic and advanced laparo- Branicki FJ, Torab FC. (2010). Diag- scopic courses planned in collaboration with industry nostic and therapeutic Laparos- who have strongly supported the project financially. Both copy in the Management of Gatric FAST and ATLS courses are accommodated as need be, Tumours. Arab Health (Show and also courses in laparoscopic gynaecological surgery Issue), 96-100. and fetal ultrasonography. FAST trainers include, cardiolo- El-Ashaal YI, Saadeldin YA, Abu-Zi- gists, nephrologists, obstetrician/gynaecologists, radiolo- dan FM. (2010). Rectovesical tract gists and surgeons. This exciting initiative has been made caused by trans-anal metallic rod possible with donations from instrument and equipment impalement. J Trauma, 68(5):1265. manufacturers. A number of Interns and Residents in the Hammad FT, Eid H, Jawas A, Abu- General Surgery training program have successfully com- Zidan F. (2010). Genitourinary pleted ATLS, FAST and laparoscopic training Courses. injuries following road traffic col- lisions: a population-based study from the Middle East. Turkish Journal of Trauma and Emergency Surgery, 16(5):449-52.

Hammad FT, Lubbad L. (2010). The effect of diclofenac sodium on renal function in reversible unilat- eral ureteric obstruction. Urol Res. [Epub ahead of print].

Hammad FT, Lammers W J, Stephen B, Lubbad L. (2010). Prop- agation of the electrical impulse in reversible unilateral ureteral obstruction as determined at high electrophysiological resolution. Journal of Urology,185(2):744-50.

Hammad FT, Lammers W J, Stephen B, Lubbad L. (2010). Propagation characteristics of the electrical impulse in the normal

100 Department of Surgery

and obstructed ureter as deter- Zidan FM. (2010). Vascular injuries Abu-Zidan FM. (2010). Trauma mined at high electrophysiological following road traffic collisions in a in child-bearing age in a high- resolution. British Journal of Urol- high-income developing country: income developing country. 2nd ogy International. [Epub ahead of a prospective cohort study. World Annual Abu Dhabi Health Service print]. J Emerg Surg, 5(1):13. (SEHA) Research Conference. Abu Dhabi, UAE. Hammad FT, Balakrishnan A. Lewis PM, Al-Belooshi A, Olsen (2010). The effect of fat and non- M, Schemitsch EH, Waddell JP. Abu Zidan FM. (2010). Biomecha- fat components of the skin-to- (2010). Prospective randomized nism of road traffic collisions. stone distance on Shockwave trial comparing alumina ceramic- Middle East Surgery, Arab Health Lithotripsy success. Journal of on-ceramic with ceramic-on-con- Congress 2010. Dubai. UAE. Endourology, 24(11):1825-9. ventional polyethylene bearings in total hip arthroplasty. Journal of Abu Zidan FM. (2010). Child- Hammad FT, Eid H., Jawas A, Arthroplasty, 25(3): 392-397. hood Trauma in the Gulf. Setting Abu-Zidan F (2010). Genitourinary Standards in Surgery Conference, injuries following road traffic col- Shaban S, Eid HO, Barka E, Abu- Dubai, UAE. lisions: A population-based study Zidan FM. (2010). Towards a from the Middle East. Turkish national trauma registry for the Abu Zidan FM. (2010). Clinical Journal of Trauma & Emergency United Arab Emirates. BMC Res reasoning in trauma management. Surgery, 16 (5):449-452. Notes, 10;3:187. Al Rahba Hospital Polytrauma Conference. Abu Dhabi, UAE. Hammad FT, Alqaiwani KM, Tadros AM, Eid HO, Abu-Zidan FM. Shirodkar SS. (2010). The role of (2010). Epidemiology of foot injury Abu Zidan FM. (2010). Critical urologists in the management of in a high-income developing thinking in ICU. Updates in Critical urological injuries during obstetric country. Injury, 41(2):137-40. Care Medicine. Al-Ain, UAE. and gynaecologic surgery. Int Uro- gynecol J Pelvic Floor Dysfunct, Abu Zidan FM. (2010). Pediat- 21(10):1237-41. k ric trauma research in the GCC countries. Arab Children Health Hammad FT, Kaya M. (2010). Congress 2010. Child Accident Development and validation of an Published Prevention. Dubai, UAE. Arabic version of the International Prostate Symptom Score. British Abstracts (Oral and Abu Zidan FM. (2010). Role of Journal of Urology International, Poster), Letters, ‘point-of-care’ ultrasound in the 105(10):1434-8. management of shock. Al Rahba Correspondence Hospital Polytrauma Conference. Hammad FT, Al Najjar A. (2010). Abu Dhabi, UAE. The effect of fat, muscle and Torab FC, Fardoun A, Branicki F. kidney on stone fragmentation by (2010). Revisional Bariatric Sur- Abu Zidan FM. (2010). Role of pre- Shockwave Lithotripsy: An in vitro gery: an experience of a tertiary hospital ultrasound in disasters. study. Journal of Endourology, bariatric center. Surgery for Obes- Disaster Management and Crisis 24(2):289-92. ity and Related Diseases 6(2): 229. Response, Middle East 2010. Abu- Dhabi, UAE. Hefny AF, Al-Ashaal YI, Bani- Hashem AM, Abu-Zidan FM. k AlMahmoud T, Al-Fazari A, Branicki (2010). Seatbelt syndrome associ- F. (2010). Postgraduate Medical ated with an isolated rectal injury: Education in the United Arab case report. World J Emerg Surg, Proceedings, Emirates: guidelines for a code of 5(1):4. ethics and professional conduct. Invited Lectures International Conference on Resi- Hefny AF, Abu-Zidan FM. (2010). and Others dency Education. Ottawa, Canada. Necrotizing fasciitis as an early manifestation of tuberculosis: Abbas AK, Hefny AF, Abu-Zidan AlMahmoud T, Munger R, Jackson report of two cases. Turkish Jour- Abbas AK, Hefny AF, Abu-Zidan WB. (2010). Comparison of ad- nal of Trauma and Emergency FM. (2010). Seatbelt compliance vanced corneal surface ablation Surgery, 16(2):174-6. and mortality in the Gulf Coop- and femtosecond Thin-Flap LASIK: eration Council countries in com- clinical outcome and changes in Hefny AF, Eid HO, Al-Bashir M, parison with other high-Income higher-order aberrations for myo- Abu-Zidan FM. (2010). Blast inju- countries. 2nd Annual Abu Dhabi pia. American Society of Cataract ries of large tyres: case series. Int J Health Service (SEHA) Research and Refractive Surgery. Boston, Surg, 8(2):151-4. Conference. Abu Dhabi, UAE. USA.

Jawas A, Hammad F, Eid HO, Abu- Abbas AK, Mirghani H, Eid HO, AlMahmoud T, Munger R. (2010).

101 Department of Surgery

Comparison of wavefront and Dhabi Trauma and Emergency Medi- Belgium. corneal aberration changes after cine Conference. Abu Dhabi, UAE. advanced corneal surface ablation El-Ashaal Y, Abu-Zidan FM. (2010). and femtosecond Thin Flap LASIK. Branicki FJ, Abu-Zidan F, Eid H, Management of trans-anal rectal The VI World Cornea Congress. Bashir M. (2010). Camel Related injuries. 2nd Annual Abu Dhabi Boston, USA. Injuries. 11th Annual Scientific Health Service (SEHA) Research Conference and AGM, College Conference. Abu Dhabi, UAE. AlMahmoud T, Munger R. Lafon- of Surgeons of East, Central and taine M, Taylor S, Jackson BW. Southern Africa/ 61st Annual Hefny A, Grivna M, Abbas KA, (2010). Advanced corneal surface Meeting Association of Surgeons Branicki FJ, Abu-Zidan FM. (2010). ablation efficacy in myopia: clinical of East Africa. Kampala, Uganda. Pediatric trauma research in outcome and changes in higher or- the Gulf Cooperation Council der aberrations. Emirates Ophthal- Branicki F, Shaban S, Ashour M, Countries. 2nd Annual Abu Dhabi mological Conference. Dubai. UAE. Bashir M, El-Ashaal Y, Abu-Zidan Health Service (SEHA) Research F. (2010). The Long Term Impact Conference. Abu Dhabi, UAE. AlMahmoud T. (2010). Allergic of an Early Analysis of a Trauma Conjunctivitis. Update in Allergy Registry. 11th Annual Scientific Hefny A, Eid H, Al-Bashir M, Abu- &Pulmonology. Al Ain, UAE. Conference and AGM, College Zidan F. (2010). Blast injuries of of Surgeons of East, Central and large tyres. A case series. 11th AlMahmoud T. (2010). Update in Southern Africa/ 61st Annual European Congress of Trauma dry eye management. Vision –X. Meeting Association of Surgeons and Emergency Surgery, Brussels, Dubai, UAE. of East Africa. Kampala, Uganda. Belgium.

AlMahmoud T, Deschenes J. Branicki FJ. (2010). Role of Surgery Hefny A, Barss P, Eid HO, Abu-Zi- (2010). Case of Uveitis. Multidisipli- for Upper Gastrointestinal Tu- dan FM. (2010). Motorcycle-related nary Meeting. Montreal, Canada. mours (GIST). 11th Annual Scien- Injuries in a High-income Develop- tific Conference and AGM, College ing Country. 2nd Annual Abu Dhabi Al Belooshi AA. (2010). Resurfacing of Surgeons of East, Central and Health Service (SEHA) Research total hip arthroplasty, is a fad or a Southern Africa/ 61st Annual Conference. Abu Dhabi, UAE. good operation? Arab Health An- Meeting Association of Surgeons nual Congress. Dubai, UAE. of East Africa. Kampala, Uganda. Jackson WB, AlMahmoud T, Munger R. (2010). Correlation Al Belooshi AA. (2010). Scaphoid Eid H, Shaban S, Lunsjo K, Barss P, between visual acuity and ocular fracture update. Upper extremity Torab F, Grivna M, El Ashaal Y, Bran- aberrations following advanced update meeting. Abu Dhabi, UAE. icki, FM Abu Zidan. (2010). Trauma surface ablations and thin flap patterns in the United Arab Emir- (femtosecond) LASIK. The Asso- Branicki FJ. (2010). Evolving Strat- ates: data from hospital-based ciation for Research in Vision and egy for Esophago-gastric GIST. trauma registry. 11th European Ophthalmology (ARVO) Confer- Gastroenterology - Part 1. 9th Mid- Congress of Trauma and Emergen- ence. Florida, USA. dle East Surgery Conference. Arab cy Surgery, Brussels, Belgium. Health. Dubai, UAE. Kayyal Y, Branicki F. (2010). Trauma Eid H, Hefny A, Idris K, Abu-Zidan F in a Morbidly Obese patient. 6th Branicki FJ. (2010). Camel related (2010). Factors affecting mortal- Middle East Abu Dhabi Trauma injuries. Grand rounds – Tawam ity of Critical Care Unit Trauma and Emergency Medicine Confer- Hospital. Al Ain, UAE. Patients. 2nd Annual Abu Dhabi ence. Abu Dhabi, UAE. Health Service (SEHA) Research Branicki FJ. (2010). Surgery for Gas- Conference. Abu Dhabi, UAE. Safi F. (2010). Biliary tract injury tric Cancer in 2010. 6th Emirates following laparoscopic surgery. Gastroenterology and Hepatology Eid H, Hefny A, Grivna M, Abu- International Surgical Conference. Conference. Dubai, UAE. Zidan F. (2010). Bicycle-related Aleppo, Syria. Injuries of hospitalized patients in Branicki F, Taji H, Al-Ashaal Y, a high-income developing coun- Safi F. (2010). Pancreatic Surgery, Ahmed I, Abu-Zidan F. (2010). try. 2nd Annual Abu Dhabi Health personal experience. International Delayed Diagnoses and Missed Service (SEHA) Research Confer- Surgical Conference. Aleppo, Syria. Injuries. 1st National Trauma Con- ence. Abu Dhabi, UAE. ference (Al Rahba Hospital). Abu Safi F. (2010). International Confer- Dhabi, UAE. El-Ashaal Y, Hefny A, Saadeldinn ence for study of the liver. Vienna, Y, Abu-Zidan F. (2010). Supe- Austria. Branicki FJ, Abu Zidan FM, Torab rior mesenteric artery syndrome. FC, Abdulla J, Kazim S, Gautam S. causing massive gastric dilatation Safi F. (2010). Surgical approach for (2010). Advanced Trauma Life Sup- in a young healthy female. 11th HCC. UAE Oncology, Dubai. UAE. port (ATLS) Courses in the United European Congress of Trauma Arab Emirates. 6th Middle East Abu and Emergency Surgery, Brussels, Safi F. (2010). Treatment of inguinal

102 Department of Surgery

hernia, what’s worthwhile? Al Noor Torab F, Fardoun A. (2010). Com- the UAE started at Tawam Hospital. Hospital. Al Ain. UAE. plications of bariatric surgery and 2nd SEHA Annual Research Con- solution. 12th World Congress of ference. Abu Dhabi. UAE. Shaban S, Ashour M, Bashir M, El endoscopic Surgery, (SAGES Meet- Ashaal Y, Branicki F and Abu Zidan ing). Washington, USA. Varghese A, AlMahmoud T, Eata- FM. (2010). The long term impact madi H, Najab I. (2010). Meibomian of early analysis of a Trauma Torab F, Fardoun A. (2010). Single gland dysfunction in pseudo- Registry. 11th European Congress incision cholecystectomy versus hypoaldosteronism. Emirates of Trauma and Emergency Surgery, laparoscopic. 12th World Congress Ophthalmological Conference. 15-18 May 2010, Brussels, Belgium. of endoscopic Surgery, (SAGES Dubai, UAE. Meeting). Washington, USA. Torab FC. (2010). SILS: Internation- al and Preliminary Local Results. Torab F, Fardoun A. (2010). Single k Arab Health Congress, Dubai, UAE. port access cholecystectomy. 12th World Congress of endoscopic Sur- Torab FC. (2010). Single Incision gery, (SAGES Meeting)Washington, RESEARCH GRANTS Laparoscopic Surgery (SILS): Inter- USA. national and UAE results. Annual United Arab Emirates University meeting of the Lebanese Endo- Torab F, Fardoun A. (2010). Morbid- scopic Surgery Association. Beirut, ity and mortality related to bariat- The effect of curcumin on the Lebanon. ric surgery: Experience of bariatric obstructed kidney in the rat surgeons in the UAE. 12th World F. T. Hammad (PI), L. Lobbad Torab FC. (2010). Training in the Congress of endoscopic Surgery, UAE. Setting Standards in Surgery (SAGES Meeting) Washington, Faculty of Medicine & Health Conference, Dubai, UAE. USA. Sciences, United Arab Emirates Torab F, Fardoun A. (2010). Single University Torab FC. (2010). Complications Incision laparoscopic surgery of Bariatric Surgery. 2nd SKMC- (SILS). International and UAE Impact of particulate air pollution Cleveland Clinic Annual Obesity results. 12th World Congress of on ischemic acute renal failure: Symposium, Abu Dhabi, UAE. endoscopic Surgery, (SAGES Meet- Possible protective effect of thy- ing). Washington, USA. moquinone Torab FC. (2010). Seminar on A. Nemmar (PI), F. T. Hammad, S. Single Incisional Laparoscopic Torab FC. (2010). Preliminary Al-Salam Surgery (SILS), 10th Mediterranean results of SILS bariatric surgery. and Middle Eastern Endoscopic 4th IFSO-EC congress, Lausanne, Others Surgery Congress, Tehran, Iran. Switzerland. Ultrasound training and Torab FC. (2010). Live Surgery on Torab FC. (2010). Gastric band education. SILS Sleeve Gastrectomy. 10th erosion: A case report, the second Mediterranean and Middle Eastern SKMC-Cleveland Clinic Annual Obes- F.M. Abu-Zidan Endoscopic Surgery Congress, ity Symposium, Abu Dhabi, UAE. Education Grant SonoSite Ltd. Tehran, Iran. Torab FC. (2010). Morbidity and Torab FC. (2010). Factors affecting mortality related to bariatric sur- k ethics in surgery. The First Annual gery: experience of surgeons in the Medical & Professional Ethics Con- UAE. 2nd SEHA Annual Research ference. Al Ain, UAE. Conference. Abu Dhabi, UAE. Torab F, Fardoun A. (2010). SILS Bariatric Surgery. 12th World Torab FC. (2010). Single Incision Congress of Endoscopic Surgery, Laparoscopic Surgery (SILS): (SAGES Meeting). Washington, USA. Results of innovative surgery in

103 Department of Surgery

2010Surgery

Standing left to right: Mr Abdulla Jamal, Mr Aboobacker CK, Prof Fikri Abu-Zidan, Dr Ali Abbas, Mr Loay Lubbad, Dr Fawaz Torab, Dr Zuhair Al Fardan, Dr Alaa Kamal Seated left to right: Prof Frank Branicki, Ms Raisa Al Manosuri, Dr Tahra Almahmoud, Prof Farouk Safi

http://www.fmhs.uaeu.ac.ae/DepartmentsSurgery Tel: 7672000 / Fax: 7672067

104 Research Priority Groups

20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICALDiabetes RESEARCH and AT Cardiovascular FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICALGenetics RESEARCH and AT Development FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICALImmunology RESEARCH AT and FMHS Immunoregulation I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICALMERGE RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICALNeurosciences RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICALOncology RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICALTrauma RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I

Diabetes and Cardiovascular Research Priority Group

Introduction Core members: The Diabetes and Cardiovascular Research Priority Group (DCRG) Prof Hussain Saadi was established on January 27, 2002, after an initial meeting Prof Abdu Adem called by the Dean in the autumn of 2001. The DCRG works Prof Chris Howarth closely with the Al Ain Diabetes Research Group and the Emirates Dr Juma Al Kaabi Diabetes Society. Dr Syed Mehboob Ali Shah Aims of the Group Prof Thomas Adrian Facilitate diabetes and cardiovascular research in the faculty. Dr Fatma Al Maskari Enhance the clinical and basic research capabilities of established Prof El-Sadig Kazzam diabetes investigators. Prof Farouk Safi Act as a channel for research funding. Prof Ernest Adeghate Act as a resource for new faculty members and for those who (Chair) may want to start research in diabetes/cardiovascular diseases. Present scientific research at national and international scientific In addition to the core members, conferences. group membership includes Publish scientific research in national and international scientific 44 other faculty members from journals. within the FMHS. Cooperate and liaise with any local, national or international agency with similar research interests. Train post-doctoral, doctoral, masters and bachelors degree students. Act as a resource unit on diabetes and cardiovascular diseases.

Activities Annual Workshop on “Update on Diabetes Mellitus Management”, March 13, 2010 The DCRG organized a one-day Annual Workshop on “Update on Diabetes Mellitus Management” on Saturday, March 13, 2010 at the Faculty of Medicine & Health Sciences, United Arab Emirates University. The Workshop attracted more than 390 delegates across the UAE and abroad. In addition to local delegates, we hosted 2 international figures in the field of diabetes, Anne Belton of Anne B Belton & Associates, Calgary, Canada and Helen McGuire, Global Education Manager, International Diabetes Federation.

The Workshop covered different areas of diabetes including: t
5IF
JNQPSUBODF
PG
1SJNBSZ
$BSF
JO
BO
JOUFHSBUFE
SFTQPOTF
UP
UIF
diabetes epidemic t
4DSFFOJOH
TUSBUFHZ
GPS
5ZQF

EJBCFUFT
NFMMJUVT
JO
UIF
6"&

107 Diabetes and Cardiovascular

t
5IF
DPNJOH

ZFBST
TUSBUFHZ
UP
QSFWFOU
BOE
on the metabolic parameters of diabetic rats. care for diabetes in the GCC states (2009-2010). t
.BOBHFNFOU
PG
5ZQF

EJBCFUFT
5SBOTMBUJOH
the recent guidelines into clinical practice Emirates Foundation Grant t
6QEBUF
PO
UIF
NBOBHFNFOU
PG

EJBCFUJD
Prof Chris Howarth [PI] dyslipidaemia 1SPHSFTTJWF
DIBOHFT
JO
FYQSFTTJPO
PG
HFOFT
t
1SFWBMFODF
PG
QFSJQIFSBM
WBTDVMBS
EJTFBTF
encoding Ca2+ signalling proteins and among type 2 diabetic in Al Ain Medical remodelling of Ca2+ proteins underlies cardiac district. muscle dysfunction in type 2 diabetic heart. t
%JBCFUFT
BOE
QFSJPEPOUBM
EJTFBTF
o
"
DPNQMFY
(2010). two-way connection. t
5ZQF

EJBCFUFT
NFMMJUVT
BOE
IZQFSUFOTJPO
Dr Fatima Al-Maskeri [PI] From guidelines to clinical practice for primary National survey of Diabetes and its care providers. complications in the UAE-Abu Dhabi phase. (2010). Themes of research include the following Neuropeptides and neurotransmitters in Collaboration with local and international diabetes institutions Trace elements in diabetes Immunology of diabetes Local Clinical pharmacology of diabetes Al Ain Diabetes Research Group Insulin and glucagon secretion Emirates Diabetes Society (Emirates Medical Effects of diabetes on cardiac muscle function Association) Epidemiology of diabetes Tawam and Jimi Hospitals, Al Ain, UAE Diabetic complications (nephropathy, Neuroscience Research Group, FMHS, UAEU neuropathy and angiopathy) Faculty of Science, UAEU -JQJET
JO
IVNBO
BOE
FYQFSJNFOUBM
EJBCFUFT
Faculty of Engineering, UAEU Metabolic syndrome and obesity Pancreas transplantation International Hypertension University of Manchester, UK Gestational diabetes James Cook University, Queensland, Australia University of Bristol, UK Grants obtained by members University of Leeds, UK FMHS Research Grant University of Central Lancashire, UK Prof Ernest Adeghate [PI] Karolinska Institut, Sweden Modulation of streptozotocin-induced diabetes Semmelweis University, Hungary CZ
PSFYJO
SFDFQUPS
 
CNRS, France

UAEU Interdisciplinary Grant Future plans Establishment of a Diabetes Research Centre Prof Chris Howarth [PI] The group is planning to establish a Diabetes &òFDUT
PG
FYFSDJTF
USBJOJOH
PO
IFBSU
GVODUJPO
JO
Research Centre. The centre will provide the Goto-Kakizaki type 2 diabetic rat. (1426-08- a facility that enables and facilitates a 02-10). multidisciplinary approach to the study of diabetes and its complications and to Sheikh Hamdan Bin Rashid Al Maktoum provide the infrastructure for diabetes related Award for Medical Sciences undergraduate and post-graduate research and Prof Chris Howarth [PI] teaching activities. Remodeling of Ca2+ transport proteins underlies cardiac muscle dysfunction in the Publications Zucker diabetic fatty rat. (2009-2010). Members of the DCRG published more than 36 diabetes-related papers in top quality Prof Ernest Adeghate [PI] peer-reviewed journals including but not Effect of pancreatic beta cell transplantation limited to BMC Public Health, Asia Pac J Public

108 Diabetes and Cardiovascular

Health, Journal of Diabetes & its Complications, The cumulative impact factors of these journals Molecular and Cellular Biochemistry, FYDFFEFE

4FF
%FQBSUNFOUT
PG
"OBUPNZ
Physiology Research, PLoS ONE, Current Biochemistry, Community Medicine, Pathology, .FEJDJOBM
$IFNJTUSZ
&YQFSJNFOUBM
BOE
$MJOJDBM
Pharmacology, Physiology, Psychiatry, Internal Endocrinology and Diabetes, Journal of Tropical Medicine and Medical Microbiology for relevant Pediatrics, Health Society Care Community, publications). Metabolic Syndrome and Related Disorders, Nutrition Metabolism and Cardiovascular Disorders, Review of Diabetes Studies in 2010.

Transmission electron micrographs of ventricular myocytes of normal (A) and diabetic (B) rats. Note severe degeneration of mitochondria (arrow) in diabetic rat. Vacuolization (arrowheads) of cytoplasmic organelles can also be observed. Magnification: X 14,000

109 Genetics and Development Research Group

Mission of the Group Consanguineous marriages are prevalent in UAE population and therefore recessive single gene disorders occur more frequently in the UAE than in other populations with over 160 recessive disorders have been reported so far. In addition, local population has a high frequency of alpha and beta thalassemia mutations and hemoglobin S. Furthermore, the incidence of multifactorial diseases such as type 2 diabetes, obesity, certain cancers, neurodegenerative and cardiovascular diseases have been steadily rising in the UAE over the past three decades. This is mainly due to the rapid socioeconomic growth and a significant SJTF
JO
MJGF
FYQFDUBODZ
5IF
SBQJE
JODSFBTF
JO
UIF
QSFWBMFODF
PG
multifactorial diseases also suggest genetic predisposition to those diseases revealed by rapid changes in lifestyle and diet. The mission of the Genetics and Development Research Group is to provide the highest quality research into the basis of genetic diseases, provide high quality health care and education. In TVQQPSU
PG
JUT
NJTTJPO
UIF
HSPVQ
TUSJWFT
UP

EFöOF
UIF
FYUFOU
of genetic, developmental and multifactorial disorders in the country; (2) be the leading source of research into the causes and pathogenesis of these disorders and (3) to seek new approaches to diagnosis, treatment and prevention of such disorders. Our NJTTJPO
JT
BMTP
UP
FEVDBUF
UIF
OFYU
HFOFSBUJPO
PG
IFBMUI
DBSF
leaders by providing continuing professional development to physicians with up to date courses and to educate the public by providing information on different genetic disorders and approaches to prevention.

Members of the Group Principal investigators members of the Genetics and Development Research Group are affiliated to different departments within the Faculty of Medicine and Health Sciences of the UAE University. The current membership of the group is:

Dr. Bassam R Ali (Pathology Department); Associate Professor of Molecular Genetics and Leader of the Genetics and Development Research Group Research interests: (1) Elucidation of the molecular defects re- sponsible for genetic disorders in the UAE and Arab populations and (2) Establishing the cellular mechanisms of genetic disorders.

110 Genetics and Development

Prof. Yousef M Abdulrazzaq (Paediatrics De- and aggregation in neurodegenerative diseases partment); Professor Dr. Sehamuddin Galadari (Biochemistry Research interests: (1) The genetics of truncus Department); Professor and Associate Dean for arteriosus (2) Metabolic disorders (3) Birth de- Research and Postgraduate Studies fects with vigabatrin, lamotrigine and gabapen- Research interest: Cell signaling and human UJO
BOE

"øBUPYJO
FòFDUT
PO
UIF
GFUVT
disease

Prof. Thomas E Adrian (Physiology Depart- Prof. Mohammad Y Hassan (Pharmacology ment); Professor and Chair of Physiology and Therapeutics Department); Professor of Research interests: Identification of diabetes Pharmacology and Therapeutics, Vice Provost susceptibility genes in UAE nationals for Medical Sciences and Dean of Medicine Research interest: The roles of neurotransmitters Prof. Lihadh Al-Gazali (Paediatrics Depart- in diabetes, epilepsy, aging and neurodegenera- ment); Professor and Senior Consultant in Clini- tive diseases cal Genetics Research interests: Delineation of the clinical Prof. Ruth Langer (Radiology Department); and molecular aspects of congenital malforma- Professor, Associate Dean for Administration tions in the UAE. and senior consultant Radiologist

Dr. Fatima Al-Jasmi, (Paediatrics Department) Dr. Hisham Mirghani (Obs/Gyne Department); Assistant Professor Associate Professor Research interests: Inborn errors of metabolism Research interest: prenatal diagnosis

Dr. Ahmad Hassan Al-Marzoouqi (Biochemis- Dr. Hassib Narchi (Paediatrics Department); As- try Department); Associate Professor sociate Professor and Acting Chair of Paediatrics 3FTFBSDI
JOUFSFTU
1SPUFJO
$PNQMFYFT
UIBU
Research interests: Causes and mechanisms of Modify Chromatin for Transcription Regulation common diseases in Middle Eastern populations

Dr. Suhail Al-Salam (Pathology Department); Prof. Tahir A Rizvi (Medical Microbiology De- Associate Professor partment); Professor Research interests: Molecular pathology of Research interest: Retroviral/lentiviral vectors for cancers in UAE human gene therapy.

Dr. Samir Attoub (Pharmacology and Thera- Dr. Hussain Saadi (Internal Medicine Depart- peutics Department); Associate Professor ment); Professor and Senior Consultant Endo- Research interest: The roles of Akt signaling in crinologist the mechanisms of cancer Research interest: The genetic causes of com- mon diseases in UAE and Arab populations Dr. Salim Bastaki (Pharmacology and Thera- peutics Department); Associate Professor Dr. Sami Shaban (Medical Education); Assistant 3FTFBSDI
JOUFSFTUT

0YJEBUJWF
QIFOPUZQJOH
Professor and genotyping UAE nationals using antide- Research Interests: Biomedical informatics, pressant drugs 2) Teratogenic effects of antiepi- health registries, e-learning, database-driven leptic drugs website design and relational databases

Dr. Srdjan Denic (Internal Medicine Depart- Prof. Abdul-Kader Souid (Paediatric Depart- ment); Associate Professor ment); Professor Research interests: (1) Effect of human inbreed- Research interests: Mechanisms of diseases ing on selection of alpha-thalassemia (2) The genetics of neutropenia Collaborations of the group members with UAE, regional and international Dr. Omar M El-Agnaf (Biochemistry Depart- organizations ment); Professor Local collaborations Research interest: The role of protein misfolding t
.JOJTUSZ
PG
)FBMUI

111 Genetics and Development

t
#JSNJOHIBN
6OJWFSTJUZ
6,
t
*NQFSJBM
$PMMFHF
-POEPO
6,
t
6OJWFSTJUZ
$PMMFHF
-POEPO
.FEJDBM
4DIPPM
6,
t
/BUJPOBM
)VNBO
(FOPNF
3FTFBSDI
*OTUJUVUF
t
/BUJPOBM
*OTUJUVUF
PG
)FBMUI
#FUIFTEB
64"
t
*OTUJUVUF
PG
)VNBO
(FOFUJDT
&SMBOHFO
Germany t
.PVOU
4JOBJ
4DIPPM
PG
.FEJDJOF
/FX
:PSL
USA t
5FMFUIPO
*OTUJUVUF
PG
(FOFUJDT
BOE
.FEJDJOF
Naples, Italy t
65
4PVUIXFTUFSO
.FEJDBM
$FOUFS
BU
%BMMBT
64"
t
*OTUJUVUF
GVS
.FEJ[JOJTDIF
(FOFUJL
#FSMJO
Germany t
$JODJOOBUJ
$IJMESFOT
)PTQJUBM
0)
64"
t
6OJWFSTJUZ
PG
0UUBXB
$BOBEB
t
.FEJDBM
6OJWFSTJUZ
PG
4PVUI
$BSPMJOB
Charleston, South Carolina

The Group Activities for 2009/2010 Seminars Dr. Umit Yasar, MD, PhD, associate Professor, Hacettepe University, Turkey Pharmacogenetics of drug-metabolizing enzymes: Implications for a safer drug therapy Date: Sunday, February 7, 2010

Dr. Bassam Ali, Associate Professor, Department of Pathology, FMHS, UAE University, UAE Trafficking Defects and Loss of Ligand Binding are the Underlying Causes of All Reported DDR2 Missense Mutations Found in SMED-SL Patients Date: Wednesday, March 10, 2010

Prof. Joseph G. Gleeson, Professor of Neuroscience & Pediatrics, University of t
4DIPPM
)FBMUI
"VUIPSJUJFT
California, San Diego, USA and Investigator, t
4IFJLI
)BNEBO
"XBSET
GPS
.FEJDBM
4DJFODFT
Howard Hughes Medical Institute t
$FOUFS
GPS
"SBC
(FOPNJD
4UVEJFT
Putting Together the Human Brain: t
$FOUSBM
7FUFSJOBSZ
3FTFBSDI
-BCPSBUPSZ
Collaboration for Discovery Date: Tuesday, April 20, 2010 Regional collaborations Sultan Qaboos University, Muscat, Sultanate of Dr. Sawsan Khuri, Bioinformatics Senior Oman Scientist, Center for Computational Science & King Faisal Specialist Hospital and Research Assistant Professor, The Dr. John T. Macdonald Center, Saudi Arabia Foundation Department of Human Genetics, University of Miami, USA International collaborations Practical Bioinformatics in the Life Sciences t
*OUFSOBUJPOBM
$MFBSJOH
)PVTF
GPS
#JSUI
%FGFDU
Date: Tuesday, April 27, 2010 Monitoring System [member] t
)BSWBSE
6OJWFSTJUZ
64"
Workshop on Bioinformatics Tools t
6OJWFSTJUZ
PG
$BMJGPSOJB
4BO
%JFHP
The group organized a workshop at FMHS on t
$BNCSJEHF
6OJWFSTJUZ
6,
“Bioinformatics Tools” (16-18th May 2010). The

112 Genetics and Development

workshop was attended by over 30 participants PhD in Genetics Program (mainly FMHS PhD and MSc students, research The group established an interdepartmental staff and faculty). The workshop was delivered PhD program in Human Genetics. The primarily by Dr. Sawsan Khuri, a bioinformatics compulsory courses for the program will be scientist associated with the University of provided by the Departments of Pathology (2 Miami, USA. The workshop provided the courses), Pediatrics (1 course) and Biochemistry participants with theoretical background and (1 course). The students will select their electives practical training in relevant bioinformatics from a pool of courses offered by various FMHS tools such as navigating genomic databases, departments. We already have two students DNA and Protein sequence alignments, protein enrolled in this program. and DNA motif discovery, protein structure/ function relationships.

Diagrma 2 shows confocal microscopy images captured using the FMHS confocal microscope illustrating the effects of several pathogenic mutations on the cellular trafficking of the DDR2 receptor (Ali et al., 2010, Hum Mol Genet., 19:2239-2250).

113 The Immunoregulation and Infection Research Priority Group

Group Leader: The main aim of the Immunoregulation and Infection Research Professor Basel al-Ramadi Priority Group (IIRPG) is to promote basic and clinical research in the immunology, microbiology, and related disciplines. Through Core Members: its wide membership, which encompasses investigators in a Professor Miodrag Lukic diverse number of departments in the Faculty of Medicine Professor Senarath Dissanayake and Health Sciences and affiliated hospitals, the Group aims to Professor Tahir Rizvi facilitate inter-departmental collaborations in basic and clinical Professor Tibor Pal research broadly related to immunological disorders, infectious Dr Gulfaraz Khan diseases, and microbial pathogenesis. Dr Mariam Al-Shamsi Dr Agnes Sonnevend In order to foster closer interactions between group members, Dr Ahmed Al-Qahtani the IIRPG launched a Lunch Seminar series in 2009. These Professor Michael Conlon Seminars have continued to attract interest and attendees Dr Maria Cabezudo now encompass everyone involved in microbiology/infectious Dr Suleiman Al Hammadi diseases/immunology research, including faculty members, Dr Eric Mensah-Brown postgraduate students, postdoctoral trainees, undergraduate Dr Fawaz Torab medical students and research assistants. Dr Suhail Abdullah Dr Ahmed Deemas Al Suwaidi A list of the lunch seminars held in 2010 is given below: Dr Walter Conca February 24, 2010 “Development of glycan adjuvants for immunotherapy” by Professor Senarath Dissanayake.

April 28, 2010 “IL-33/ST2 Signaling in Tumor Immunity and Autoimmunity” by Professor Miodrag Lukic.

September 28, 2010 “The MyD88 protein: a key regulator of immune responses” by Professor Basel al-Ramadi.

0DUPCFS


i/PWFM
NFUIPE
GPS
NFBTVSJOH
PYZHFO
consumption by cells and tissues, biological applications” by Dr Mariam al-Shamsi.

November 23, 2010 “Functional analysis of estrogen receptor- alpha using conditional knockout mice” by Dr Sohaib Khan, PhD, Professor & Vice Chair, Department of Cancer & Cell Biology, Vontz Center for Molecular Studies, UC College of Medicine, Cincinnati.

Original Publications by IIRPG members: Publication details of the members of the Immunoregulation and Infection Research Priority Group can be found under

114 Immunoregulation & Infection

their respective FMHS departments (refer to departmental reports as below):

Professor Basel al-Ramadi (Microbiology & Immunology) Professor Miodrag Lukic (Microbiology & Immunology) Professor Senarath Dissanayake (Microbiology & Immunology) Professor Tahir Rizvi (Microbiology & Immunology) Professor Tibor Pal (Microbiology& Immunology) Dr Gulfaraz Khan (Microbiology & Immunology) Dr Mariam Al-Shamsi (Microbiology & Immunology) Dr Agnes Sonnevend (Microbiology & Immunology) Dr Ahmed Al-Qahtani (Microbiology & Immunology) Dr Eric Mensah-Brown ((Anatomy) Dr Maria Cabezudo (Biochemistry) Dr Walter Conca (Internal Medicine) Dr Suleiman Al Hammadi (Paediatrics) Dr Ahmed Deemas Al Suwaidi (Paediatrics) Dr Suhail Abdullah (Pathology)

115 Medical Education Research Group

Chair Mission of the Group Prof M McLean To act as a co-ordinating body within the Faculty of Medicine and Health Sciences (UAEU) for individuals or groups interested Core members in medical education in order to promote scholarly activities in Dr E Abuwari teaching and learning locally, regionally and internationally. Dr T Al Mahmoud Dr M Grivna PRIMARY AIMS include Prof C Howarth t
%FWFMPQJOH
BO
FUIPT
PG
NFEJDBM
FEVDBUJPO
SFTFBSDI
XJUIJO
UIF
Dr H Narchi FMHS Dr S Shaban Dr A Shehab t
1SPWJEJOH
TUBò
EFWFMPQNFOU
UP
QSPNPUF
NFEJDBM
FEVDBUJPO
Ms G Kershaw research through workshops, journal clubs, etc.

t
1SPWJEJOH
HVJEBODF
BOE
SFTPVSDFT
GPS
UIPTF
JOUFSFTUFE
JO
medical education research

t
1SPNPUJOH
BOE
GBDJMJUBUJOH
UFBDIJOH
BOE
MFBSOJOH
TDIPMBSTIJQ
by publishing research in peer-reviewed journals, conference attendance, etc.

t
$PPSEJOBUJOH
NFEJDBM
FEVDBUJPO
SFTFBSDI
BDUJWJUJFT
XJUIJO
UIF
FMHS

t
1SPNPUJOH
NFEJDBM
FEVDBUJPO
SFTFBSDI
XJUI
UIF
(VMG
SFHJPO
BOE
internationally by establishing networks of collaborators

t
4FDVSJOH
GVOEJOH
GPS
NFEJDBM
SFTFBSDI
BDUJWJUJFT

t
&TUBCMJTIJOH
GPDVT
BSFBT
JO
SFTFBSDI
JO
UFSNT
PG
UIF
DVSSFOU
BOE
future trends in medical education

t
$PNNVOJDBUJOH
SFTVMUT
PG
SFTFBSDI
BDUJWJUJFT
UP
EFDJTJPO
BOE
policy-makers

t
*OWPMWJOH
TUVEFOUT
JO
UIF
BDUJWJUJFT
PG
.&3(&
XIFSFWFS
appropriate

Activities The group meets every two months, usually discussing a topic of interest suggested by members of the group.

116 Medical Education

January: Student evaluation of faculty. A survey display, and timetabling of sessions. [http:// was circulated to faculty and students to gauge www.fmhs.uaeu.ac.ae/fmhscms/]: Shaban perceptions (Abuwari, McLean) March: Assessment of professionalism. Dr Tahra 6. Effective use of electronic assessment for Al Mahmoud has applied for ethical approval to the Faculty of Medicine and Health Sciences, survey interns and residents about witnessing UAEU. Electronic assessment involves or practicing unprofessional behaviour question management and data banks as well May: A visiting PhD student, Dr Sereen Al Khalili as assessment delivery and analysis: Shaban (USA) presented a seminar entitled ““The historic teaching of Anatomy and the trend towards more digital media”. She demonstrated some of the 3D material she is developing and evaluating. There is the possibility of FMHS students being included in the project.

RESEARCH ACTIVITIES

1. Medical students’ perceptions of their first encounter in the Anatomy dissection room: McLean, Shehab (Anatomy)

2. Higher-achieving medical students’ perceptions of their success: McLean

3. Student and staff perceptions of faculty evaluation: Aburawi (Paediatrics), Shaban, McLean

4. Preparedness for medical practice: Final year medical students, McLean

 Effective use of a medical school curriculum management system for the Faculty of Medicine and Health Sciences, UAEU. A database-driven secure website allows multiple level access for administrators, faculty, and students. Features include managing teaching session information, student attendance, instructor conflict

117 Neuroscience Research Group

Group Leader The UAE University Neuroscience Group was officially formed in Professor Omar El-Agnaf 2006 by a Decree from the Vice Chancellor of the UAE University. (Biochemistry Department) Core Members Prof. Milos Ljubisavljevic The group consists of basic scientists and clinicians with a com- (Physiology Department) mon interest in the nervous system. The primary goal of the Dr. Murat Oz group is to strengthen collaborative research ties between its (Pharmacology Department) members and promote neuroscience research in the UAE and Prof. Peter Corr the region. The group develop educational programs at the UAE (Radiology Department) Dr. Ossama Osman University that lead to higher degrees in Neuroscience, organ- (Psychiatry Department) ize seminars, congresses and workshops, participate in scientific Members: activities of other groups in the field of neuroscience Moreover, Prof. Abdu Adem the group develops educational programs, provides professional Dr. Safa Shehab development activities, information and educational resources Dr. Eric Mensah-Brown Prof. Wim Lammers for neuroscientists at all stages of their careers in the UAE and the Prof. Ernest Adeghate Region. Prof. Omer El-Rufaie Dr. Fadwa El-Mughairibi Major Achievements for 2010 Dr. Fatima Aljasmi Dr. Maria Cabezudo Besides the monthly journal clubs meetings and the evening Prof. Basel Al Ramadi seminars, the group activities for 2010 was mainly focusing on Dr. Gururaj Aithala launching two major activities: First the “2nd IBRO-UAE Neu- Dr. Taha Amir SPTDJFODF
4DIPPM
o
'VOEBNFOUBMT
PG
#BTJD
BOE
$MJOJDBM
/FVSP- Dr. Sami Abdel-Kawi TDJFODFw
GSPN
+BOVBSZ
UI
UP
'FCSVBSZ
UI

BU
UIF
'BDVMUZ
PG
Prof. Lihadh Al-Gazali Prof. Mohamed Fahim .FEJDJOF
BOE
)FBMUI
4DJFODFT
o
6"&
6OJWFSTJUZ
BOE
TFDPOE
UIF
Prof. Mohammed Hassan “1st IBRO Middle East Neuroscience Conference” from February Dr. Sehamuddin Galadari 
o


Dr. Chris Howarth Dr. AbdelAzim Mabrook “2nd IBRO-UAE Neuroscience School – Fundamentals of Basic Dr. Salim Bastaki Dr. Juman Kubba and Clinical Neuroscience” Dr. Amr A. Amin The 2nd UAE-IBRO Neuroscience School has been jointly organ- Dr. Ahmed Al Marzouqi ized by UAEU Neuroscience Group and the International Brain Dr. Klaus van Gorkom Research Organization (IBRO). It brought together 32 students, Dr. Mahmoud Al Sultan clinicians, and young scientists from different countries in the Dr. Hamdy Moselhy Dr. Mohamed Omar Salem region, including Algeria, Egypt, Iraq, Libya, Jordan, Lebanon, Dr. Amin Bahi .PSPDDP
0NBO
1BMFTUJOF
4BVEJ
"SBCJB
5VOJTJB
6"&
BOE
:FNFO
Prof. Johann Braun Dr. Leena Amiri The primary goal of the School was to provide students with a Dr. Kanita Dervic general understanding of the basic principles of neuroscience, Prof. Sehamdduin Galadari Por. John Conlon and to encourage them to pursue careers in research and Dr. Bassam Ali academia. Through a series of lectures, practical workshops, and Dr. Suhail Al Salam EJTDVTTJPO
TFTTJPOT
TUVEFOUT
XFSF
FYQPTFE
UP
UIF
GVOEBNFOUBMT
Prof. Mohamed Y Hasan Baniyas of neuroscience, from the molecular to the behavioral and clinical

118 Neuroscience

levels. The course provided students with four and neurological disorders. Current issues and general skill sets: challenges in these fields were debated during t
/FVSPTDJFODF
FEVDBUJPO
the Conference in order to set better standards t
&YQFSJNFOUBM
XPSL
in research, medical service and education. The t
0SBM
QSFTFOUBUJPOT
conference themes included: t
1SPGFTTJPOBM
EFWFMPQNFOU
t
/FVSPEFHFOFSBUJWF
EJTFBTFT
t
/FVSPQTZDIJBUSZ
BOE
CFIBWJPS
The goal of the school is also to bring young t
/FVSPUSBOTNJUUFST
BOE
OFVSPQFQUJEFT
JO


neuroscientists from the Middle East and North health and disease Africa (MENA) together to build future collabo- t
/FVSPJNBHJOH
JO
IFBMUI
BOE
EJTFBTFT
rations between them. The School will provide t
/FVSPJNNVOPMPHZ
TUVEFOUT
B
GPSVN
GPS
UIF
FYDIBOHF
PG
JEFBT
t
/FVSPFOEPDSJOPMPHZ
through interaction with colleagues from the re- t
/FVSPQBUIJD
1BJO
gion and with renowned international scientist The conference provided local scientists with

and clinicians in the field of neuroscience. In this the opportunity to network and establish col- event we had strong representations and par- laborations with leading international scientists ticipation of Neuroscientists from MENA region JO
UIF
öFME
BT
XFMM
BT
FYQBUSJBUF
OFVSPTDJFOUJTUT
working abroad. We feel strongly that a partner- from the region. According to the IBRO officers ship between the two communities is crucial for and the organizers of the School and Confer- advancing neuroscience research and capacity FODF
UIF
OFVSPTDJFODF
DPNNVOJUZ
UIBU
FYJTUT
building in the region. In addition to the scien- within the Middle East, while fragmented, is tific program, the school represents a unique highly dedicated and eager to help pave the opportunity to collectively assess the current way for improved infrastructure and develop- state of training and research in the region and ment programs for future generations of neuro- formulate various programs and initiatives to 1) scientists. To help advance and coordinate these promote the field of neuroscience in the region; efforts, the leadership of IBRO has committed to 2) support neuroscientists and neuroscience the establishment of an IBRO Middle East chap- programs in the region; 3) develop programs/ ter. The conference participants also discussed initiatives to attract young scientists to pursue the preparation for developing a Middle East academic and research careers in the field of Society of Neuroscience. neuroscience. IBRO is the global neuroscience federation “1st IBRO Middle East Neuroscience dedicated to the promotion of neuroscience Conference” and communication between brain research- The aim of the Conference was to bring togeth- ers around the world, with special emphasis on er neuroscientists from the Middle East, North assisting young investigators in the developing Africa and the rest of the world to discuss the world. Incorporated in 1961, IBRO now counts advances in the field of basic and clinical neu- 84 member societies in 61 countries around the roscience. The Conference presented a balance world, with a total membership of more than between the recent advances in basic neuro-  
OFVSPTDJFOUJTUT
science research and treatments of psychiatric

119 Neuroscience

International Research Collaboration The Faculty of Medicine and Health Sciences - United Arab Emirates signed MoU with the Faculty of Medicine, Lund University Sweden to promote their cooperation in academic education and research in the field of Neurosciences. The cooperation also includes:


&YDIBOHF
PG
HSBEVBUF
BOE
Center of Molecular Neurobiology, University of Glasgow postgraduate students University of Hamburg, Germany University of Groningen, Nether- - Joint teaching activities Harvard Medical School, USA lands - Joint supervision of PhD students Imperial College, London University of Turin, Italy - Joint research activities *OTUJUVU
1BTUFVS
EF
-JMMF
$FEFY
University of Xi'an, China  7JTJUT
CZ
BOE
FYDIBOHF
PG
France Utrecht Medical Centre, Nether- scholars, teachers and other staff. Institutes for Medical Research lands BOE
/FVSPMPHZ
#FMHSBEF
:VHP- Scientific Collaboration slavia Summary of Grants & Several members of the group Iowa Medical School, USA Publications 2010 hold membership in prestigious James Cook University, Queens- (refer to departmental reports as organizations and serve on the land, Australia below): editorial board of international Lancaster University, UK Shehab S (Anatomy). journals and committees. Also the Kyoto Prefectural University of Adeghate E (Anatomy). group members collaborate with a Medicine, Kyoto, Japan Mensah-Brown E (Anatomy). number of research groups, insti- Laboratory of Neurogenetics, Dietrich Lorke (Anatomy). tutions and organizations within National Institute on Aging, Mary- Conlon JM (Biochemistry). the UAE & abroad. land, USA El-Agnaf O (Biochemistry). Mayo Clinic, Florida, USA Galadari S (Biochemistry). UAE: Manchester University, UK Nicholls MG (Internal Medicine). Al Ain Hospital, Al Ain McMaster University, Canada Lukic M (Medical Microbiology). Central Veterinary Research Labo- National Institute of Health, USA Al-Gazali L (Paediatrics). ratory, Dubai Royal Free & University College Gururaj A (Paediatrics). Centre for Arab Genomic Study London Medical School, UK Petroianu G (Pharmacology). Faculty of Science, UAEU SGHMS, University of London, UK Adem A (Pharmacology). Hamdan Award for Medical Sci- Sultan Qaboos University, Muscat, )BTBO
.: 1IBSNBDPMPHZ 
ences Oman Bastaki S (Pharmacology). Tawam Hospital, Al Ain The Karolinska Institute, Sweden Attoub S (Pharmacology). Zayed University, Dubai 5IF
2VFFOT
6OJWFSTJUZ
PG
#FMGBTU
Murat Oz (Pharmacology). UK Fahim M (Physiology). Abroad: University of Manchester, UK Lammers W (Physiology). Lund University Medical School, University of Aarhus, Denmark Ljubisavljevic M (Physiology). Sweden Universita La Sapienza, Rome El-Rufaie O (Psychiatry). Boston College, MA, USA University of Aalborg, Denmark Raguram R (Psychiatry). Bogomeletz Institute, Ukraine University of Amsterdam, Nether- Osman O (Psychiatry). Conway Institute, Dublin, Ireland lands Moselhy H (Psychiatry). $PMVNCJB
6OJWFSTJUZ
/:
64"
University of Bonn, Germany Salem M (Psychiatry). Chapman University, USA University of California and San Corr P (Radiology). Chinese University of Hong Kong, Diego, USA Gorkom van K (Radiology). China University of Gevle, Sweden

120 Oncology Research Group

Introduction Group Leader: The Oncology Research Group (ORG) comprises colleagues at Prof Thomas E Adrian FMHS and the Abu Dhabi Health Authority, who share an interest in oncology research. The Chair of this group is Prof. Thomas Members: Adrian and the Vice-Chair is Prof. Frank Branicki. Dr. Sanjay Jain at Faculty of Medicine and Tawam Hospital is the Deputy Chair. Health Sciences: Prof Frank Branicki Objectives Prof Basel al-Ramadi t
5P
QSPNPUF
DBODFS
SFTFBSDI
o
CFJOH
B
DBUBMZTU
GPS
SFTFBSDI
Prof Farouk Safi activity Prof Haider Raza Prof John M. Conlon t
5P
DSFBUF
B
GPSVN
GPS
DPMMBCPSBUJPO
CFUXFFO
'BDVMUZ
NFNCFST
Prof Mohammad-Reza Sadeghi basic scientists and colleagues in clinical disciplines, Faculty Prof Omar El-Agnaf staff and colleagues of the Abu Dhabi Health Authority dealing Prof Ruth Langer with oncology. Prof Sherif Karam Prof Tahir Rizvi t
5P
DSFBUF
BOE
NBJOUBJO
BO
JOWFOUPSZ
PG
Dr Ahmed Al-Marzouqi - research activities Dr Fawaz Torab - resources available Dr Gulfaraz Khan 
CBTJD
SFTFBSDI
FYQFSUJTF
Dr Maria JF Cabezudo - available clinical services Dr Samir Attoub 
TQFDJBMUZ
JOUFSFTUT
o
TVCTQFDJBMUJFT
Dr Sehamuddin Galadari 
JOEJWJEVBMT
o
SFHJTUSZ
PG
JOUFSFTU
JO
0ODPMPHZ
Dr Srdjan Denic Dr Suhail Al-Salam t
5P
BDU
BT
B
SFGFSFODF
HSPVQ
SFHBSEJOH
DBODFS
SFTFBSDI
BOE
UAE University: funding Dr Amr Amin Dr Mohammad Khasanneh t
5P
BDU
BT
BO
"EWJTPSZ
CPEZ
UP
UIF
"CV
%IBCJ
)FBMUI
"VUIPSJUZ
Dr Rabah Iratni regarding cancer issues of national interest, e.g. breast cancer Dr Soleiman Hisaindee screening, cervical screening, risk factors Tawam Hospital: Dr Sanjay Jain [Dep. Chair] t
5P
DSFBUF
B
VOJöFE
MJTU
PG
BMM
DBODFSSFMBUFE
FEVDBUJPOBM
BDUJWJUJFT
Dr Anjum Naveed countrywide Dr Hakam El Taji Dr Karim Elmasry t
5P
BDU
BT
BO
"EWJTPSZ
CPEZ
GPS
FEVDBUJPO
SFHBSEJOH
DBODFS
Dr Mohammed Jaloudi organizing lectures on cancer, cancer conferences and meetings Dr Saad G. Aswad at a local and national level t
5P
QSPNPUF
RVBMJUZ
DPOUSPM
JO
UIF
NBOBHFNFOU
PG
QBUJFOUT
XJUI
cancer

121 Oncology

Membership Research Activities This year has seen an increase in membership, During 2010, members of the ORG received partly with members from the Department of a total of 31 research grants for their work, 0ODPMPHZ
JO
UIF
+PIOT
)PQLJOT
5BXBN
)PTQJUBM
JODMVEJOH
OJOF
BXBSET
GSPN
UIF
5FSSZ
'PY
and partly from our colleagues in the faculty Fund for Cancer Research, two UAE University of Science that are working in the cancer area. Interdisciplinary Awards, three UAE University The group is inclusive and is very pleased to Individual Awards, two from the Emirates welcome these new members into the fold. Foundation, two from the Sheikh Hamdan Awards, Three from the National Research Cancer Database Foundation/EAEU, and one form the US National Members of the group are supporting efforts Cancer Institute. In 2010, members of the ORG to improve the national cancer register at published 21 papers in peer-reviewed journals. Tawam hospital. This is considered to be the cornerstone of cancer surveillance in the UAE BOE
XJMM
QSPWJEF
UIF
UPPM
UP
NFBTVSF
UIF
OBUJPOT
progress against cancer. A committee has been set up under the leadership of Dr. Sanjay Jain to work on all aspects of the registry. The group recently enlisted our local bioinformatics FYQFSU
%S
4BNJ
4IBCBO
UP
IFMQ
UP
JNQSPWF
the database. In the future all government and private healthcare providers in the UAE will contribute to the registry.

Tissue Bank The group considers this to be a valuable resource for oncology research in the UAE. The bank will provide for the collection, processing and storage of human tumors and appropriate control tissues for research. The bank will help to foster collaborations between clinical oncologists and basic scientists at the FMHS. Approval for the tissue bank from the human ethics committee is in place, although approval for individual projects utilizing tissue will have to be obtained by the project investigators. The equipment and staff for the tissue procurement bank are in place. A subcommittee has developed protocols for tissue collection and storage as well as other issues, such as ethical approval, consent, maintenance of records, authorship recognition for surgeons and pathologists participating in tissue collection, etc.

Research Day for Projects Funded by the Terry Fox Fund for Cancer Research A cancer research day is being planned for the autumn of 2011. This meeting will focus on presentations of research projects currently GVOEFE
CZ
UIF
5FSSZ
'PY
'VOE
GPS
$BODFS
Research.

122 Trauma Research Group

Summary Core Members: During 2010 the Trauma Group has made major contributions in trauma education and research both nationally and Faculty of Medicine and Health internationally. The “hands on training” in point-of-care Sciences ultrasound has continued to flourish. The members of the Trauma Professor Fikri Abu-Zidan Group published 10 papers related to trauma in international Professor Frank Branicki refereed journals, and presented more than thirty abstracts at Professor Peter Corr national and international meetings. Trauma Group members Professor Elsadig Kazzam were actively involved in the preparation of the Second Assoc Prof Fawaz Torab International Conference on Trauma Management, Critical Care Assoc Prof Fayez Hammad and Prevention which will be held in 2011. Assoc Prof Michael Grivna Asst Prof Ali Jawas Mission Asst Prof Sami Shaban Our mission is to promote and perform research and education of Dr Mohamed Sadig a high standard in the field of trauma so as to improve patient care. Dr Ashraf Hefny Dr Alaa Abbas Major achievements of the Trauma Group in 2010 include: Mr Abdulla Jamal A) Road Traffic Collision Registry: This project has run as planned and was successfully completed. Al Rahba Hospital, Abu Dhabi We have collected detailed information on more than 1000 Dr Masoud Bashir patients involved in road traffic collisions and pre-event Tawam Hospital information. A full time Senior Research Fellow, Dr Ashraf Hefny, Dr Said Abuhasna and a Research Fellow, Dr Alaa Abbas, have been appointed to Dr Mohammad Al Bashir analyze the data of this registry. The Trauma Group carried their Dr Abdel Norueldin FYQFSJFODF
JO
UIJT
BSFB
UP
PUIFS
IPTQJUBMT
BOE
BTTJTUFE
5BXBN
Dr Masoud ur Rahman Hospital, Al-Ain Hospital, Al-Rahba Hospital (Abu Dhabi) and Dr Hani Eid Rashid Hospital (Dubai) to start their Registries. Our ultimate goal is the establishment of a nationwide registry. Al Ain Hospital Professor Stefan Marlovits B) Participation in trauma training courses Dr Yousef El Ashaal The Trauma Group was actively involved in the organization and Dr Mohammad Kamal Idris conduct of numerous courses.

1) ATLS Provider and Instructor Courses: It was deemed essential to train UAE doctors using ATLS principles to improve UIF
NBOBHFNFOU
PG
USBVNB
QBUJFOUT
&MFWFO
IVOESFE
TJYUZ
TFWFO
doctors have taken the Provider Course to date countrywide in UAE. We have been encouraged by the increasing support and popularity of ATLS in the UAE. This course has been conducted at the Faculty of Medicine and Health Sciences several times every year since 2004 (Fig 1). A greater awareness of the value of

123 Trauma

ATLS enhancement of the early management of severe trauma is more evident in our setting.

2) Point-of-Care Ultrasound Courses. Twenty five courses have been run since 2004. 427 doctors have received “hands on” training on Point-of-Care ultrasound (Fig 2). The majority were senior registrars from Emergency Medicine (Fig 3). We have noticed increasing support and popularity for Point-of-Care Ultrasound in clinical practice in our setting. The demand from participants, local and overseas, is increasing. These activities run under the umbrella of The Fig 1: ATLS Provider course has been conducted several times Clinical Skills Training Centre at the Faculty of every year at the Faculty of Medicine and Health Sciences. Medicine and Health Sciences, UAE University.

3) Advanced Trauma Operative Management (ATOM) Course: Members of the Trauma Group were actively involved as instructors of the ATOM Course of the American College of Surgeons which is regularly run in Dubai. This course teaches surgeons techniques, decision making, and operative skills for penetrating trauma (Fig 4).

C) Preparation for the Second International Fig 2: Training on inserting ultrasound guided Conference on Trauma Management, Critical intravenous cannulation. Care and Prevention The Trauma Group has been actively involved in planning the Second International Conference on Trauma Management, Critical Care and Prevention. The above conference will take place at the Danat Hotel and Resort at Al-Ain on 21-24 February 2011. The Conference is an initiative of the Trauma Group at the Faculty of Medicine and Health Sciences (FMHS), United Arab Emirates University. Fig 3. Specialty and rank of trained participants of Point of Care Ultrasound Courses. Five organizations are involved in the preparation of this conference: 1. Critical Care Department, Tawam Hospital in affiliation with Johns Hopkins Medicine. 2. Trauma Group, Faculty of Medicine and Health Sciences, UAE University. 3. Al-Ain Hospital managed by University of Vienna/Va Med. 4. Health Authority Abu Dhabi (HAAD). 
4IFJLI
)BNEBO
"XBSET
GPS
.FEJDBM
4DJFODFT

The scientific program was built on controversial themes. Parallel sessions will cover three main areas: Critical Care, Trauma Management, and Fig 4: Members of the Trauma Group were actively Injury Prevention. Four workshops are to be involved as instructors of the ATOM Course. held on 21 February 2011. These will include

124 Trauma

AIBOET
PO
USBJOJOH
JO
GPVS
BSFBT
'PDVTFE
relevant Departmental Reports (Department Assesment Sonography of Trauma, Critical Care of Surgery, and Department of Community Ultrasound, High Frequency Ventilation, and Medicine). reading a trauma chest-X-ray. F) International recognition: 4JYUFFO
XFMM
LOPXO
JOUFSOBUJPOBM
FYQFSUT
GSPN
1. Professor Abu-Zidan was the Local Chair of North America, Europe, Asia, Africa, Australia, the Disaster management and Crisis Response New Zealand and the GCC countries have Middle East Conference 2010, Abu Dahbi, 24- accepted the participation in the conference. 
UI
.BZ

This International Conference will provide a 2. Professor Abu-Zidan was the Chair of the GPSVN
GPS
UIF
FYDIBOHF
PG
JEFBT
BOE
LOPXMFEHF
Organizing Committee of the 6th Middle concerning trauma management and critical East Trauma, Accident and Emergency care as well as strategies for optimization Conference, 17-19 October 2010, Abu Dhabi, prevention. The meeting will focus on recent UAE. advances and controversies through interaction 3. Professor Abu-Zidan has been invited to be with renowned international speakers. The the Guest Editor for a special symposium on Conference will be of interest in particular to Emergency Sonography for the Journal of Emergency Physicians, Critical Care Physicians, Emergencies Trauma and Shock. Radiologists, Surgeons, Nursing Staff, Pre- hospital Staff as well as Epidemiologists. Issues Awards: to be addressed include management and A poster entitled “Seatbelt Compliance and critical care of trauma patients, abdominal Mortality in the Gulf Cooperation Council trauma, angioembolization, and new trends Countries in Comparison with Other High- in trauma research. Specific important topic Income Countries” by Alaa K Abbas, Ashraf F sessions including psychological aspects of Hefny, Fikri M Abu-Zidan, won the first prize of trauma, clinical reasoning, trauma education the 2nd SEHA conference, Abu-Dhabi 12-13 and training, and injury prevention will also be December 2010 over 78 posters (Fig 5). featured. Fig 5: Dr Alaa Abbas (middle) D) Successful Grants has won the best poster Grants prize for the second t
&EVDBUJPOBM
(SBOU
UP
TVQQPSU
1PJOU
PG
$BSF
SEHA conference on his work on the role Ultrasound courses, Sonosite, Middle East. of seatbelts on injury t
8PNFOT
BXBSFOFTT
BUUJUVEF
BOE
QSBDUJDF
prevention in the GCC regarding the risk of baby walkers: A post- countries. interventional study. UAE University. Media Reports on Trauma Group activities Details of these grants are to be found in the The Trauma Group research activities on relevant Departmental Reports (Department Trauma Registries and occupational injuries of Surgery and Department of Community have attracted considerable Media attention Medicine). last year with major coverage on the need for national statistics regarding trauma patients. E) Publications and Abstracts This included: In 2010, the group has published 10 papers related to trauma in international refereed 1. ‘Statistics help deliver health messages journals. Both quality and quantity of research CFUUFS
,IBMFFK
5JNFT
UI
0DUPCFS

has improved. These papers stemmed from http://www.khaleejtimes.com/displayarticle. collaborative work with Tawam and Al-Ain BTQ YöMFEBUBUIFVBF0DUPCFS
Hospitals networking between the University UIFVBF@0DUPCFSYNMTFDUJPOUIFVBFDPM
and these two institutions. The group has 2. UAE : Safety Fears for High-Rise Cleaners. The presented more than thirty abstracts and oral National, Tuesday, September 07, 2010 presentations at national and international http://www.daijiworld.com/news/news_disp. meetings in 2010. Details of these publications BTQ O@JEO@UJU6"& " 4BGFUZ 'F
and presentations are also to be found in the ars+for+High-Rise+Cleaners

125

Medical Student Research

20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I

Medical Student Research

We believe that research is becoming an increasingly important part of career development for medical students. The Faculty of Medicine & Health Sciences (FMHS) provides a wide variety of opportunities for students to participate in research which includes both curricular and FYUSBDVSSJDVMBS
SFTFBSDI
4UVEFOUT
BSF
HJWFO
BO
JOUSPEVDUJPO
UP
SFTFBSDI
JO
.FEJDBM
4DJFODFT
ZFBS

6OJU

UP
QSPWJEF
UIF
OFDFTTBSZ
CBDLHSPVOE
UP
QMBO
BOE
FYFDVUF
SFTFBSDI
QSPKFDUT
4UVEFOUT
BSF
told about the research interests of faculty and the special interest groups. Planning and design of research projects, research ethics, research project funding and biostatistics are introduced. The program culminates with visits to the research laboratories.

0QQPSUVOJUJFT
GPS
FYUSBDVSSJDVMBS
SFTFBSDI
laboratory of Professor Saadeh Suleiman at include laboratory attachments, summer the Bristol Heart Institute, University of Bristol research projects and the UK Research and Shaikha Ahmed Saif Al-Eisaei visited the Scholarship program. Students are encouraged laboratory of Professor Malcolm Alison at the to join research laboratories and to shadow Centre for Diabetes, Barts & The London School research activities. It is hoped that some of of Medicine. these attachments will lead to long term ‘The 7th Scientific Conference for Medical attachments. The summer holidays are a 4UVEFOUT
JO
UIF
($$
$PVOUSJFT
XBT
IFME
JO
good time for student research and more UIF
A$FSFNPOJBM
)BMM
BOE
$POGFSFODF
$FOUSF
UIBO

TUVEFOUT
XFSF
JOWPMWFE
JO
SFTFBSDI
at King Abdulaziz University, Jeddah, Saudi activities during the summer of 2010. The "SBCJB

o

'FCSVBSZ

5IF
TMPHBO
GPS
UK Research Scholarship program provides the conference was ‘When students become opportunities for selected students to visit TDJFOUJTUT
5IF
FWFOU
BUUSBDUFE
NPSF
UIBO
 
UK Research Laboratories during the summer. delegates mainly from the GCC Countries Typically students will have been working in but a few from other countries including FMHS laboratories and would like to visit a UK Czechoslovakia, India, Pakistan, Iran and laboratory to learn new techniques and develop /JHFSJB
5IF
DPOGFSFODF
JODMVEFE

LFZOPUF
their research. During the summer of 2010 QSFTFOUBUJPOT

PSBM

QPTUFST

XPSLTIPQT
UISFF
TUVEFOUT
WJTJUFE
6,
o
"MBB
4FIBNVEEJO
and a variety of social events. The keynote Husain Galadari visited the laboratory of speakers included: Professor Philip Agop Philip Professor Howard Morris at Imperial College, (Wayne State University, USA), Doctor Ilham Salama Abdulbasit Al-Majed visited the Saleh Abuljadayel (1996-2000 headed TriStem

129 Medical Student Research

Research at the London Hospital, Kings College, University, Turkey), Doctor Delia Wolf (Harvard Downing College, University of Cambridge and School of Public Health, USA). The themes of Addenbroke Hospital, UK), Doctor Salwa B. Al- the keynote speakers were; Cancer, Stem cells, Aidarous (King Khalid National Guard Hospital, Osteoporosis, Medical Education and Medical Jeddah, Saudi Arabia), Professor Sabri Kemahli Ethics, respectively. (Al-Kharj University, Saudi Arabia and Ankara Our delegation of 76 students contributed 9 oral and 14 poster abstracts. Professor Reza Sadeghi kindly provided a workshop entitled: A1SPHSFTTJWF
NVTDMF
SFMBYBUJPO
USBJOJOH

Our students received three awards for oral and poster presentations. Al-Ketbi MI, Dhanya S, Fernandez-Cabezudo MJ, al-Ramadi BK. FMHS, UAE University won first prize for an oral presentation entitled: ‘The role of MyD88 protein and TLR signaling pathway in QSPUFDUJPO
BHBJOTU
CBDUFSJBM
JOGFDUJPOT
Marzouqi FM, Al Mansouri A, Shaban S, Harvey S, Souid A-K. FMHS, UAE University XPO
öSTU
QSJ[F
GPS
B
QPTUFS
FOUJUMFE
A0YZHFO
measurements via phosphorescence: biological BQQMJDBUJPOT
Al Ameri MMSS, Al Ahbabi S, Al Dhaheri A, Al Zaabi A, Al Mansouri L, Hameed R, Laleye L, Abbas T, Adeghate E. FMHS, UAE University won third prize for a poster entitled: ‘Effect of camel milk on the metabolic parameters of type 1 EJBCFUFT
NFMMJUVT

In December 2010 some of our students BUUFOEFE
A5IF
UI
6"&
.FEJDBM
4UVEFOU
$POGFSFODF
XIJDI
XBT
IFME
JO
3BT
"M
,IBJNBI
Mariam Salem Khamis Matar Alkaabi won first prize for her poster entitled: ‘Cigarette smoking BOE
JUT
DPSSFMBUFT
BNPOH
ZPVUI
JO
6"&
5IF
project was supervised by Dr Syed Ali Shah (Community Medicine). During the 2nd SEHA conference in Abu Dhabi 
"MEIBIFSJ
8
"EJ
.
"MLFOEJ
'
"MLBBCJ
M, Karam SM won best oral presentation for an oral presentation entitled: ‘Alteration of DBSCPIZESBUF
FYQSFTTJPO
BOE
TUFN
DFMMT
EVSJOH
CSFBTU
DBODFS
EFWFMPQNFOU
130 Medical Student Research

Biomedical Science Research Day

Dr. Abdullah Saad Al-Khanbashi, Vice Chancellor of the United Arab Emirates University and Prof. Mohamed Yousif Hasan Baniyas, Vice Provost, Medical Sciences and Dean, Faculty of Medicine and Health Sciences during the Students Scientific poster sessions at the Biomedial Research Day held at the FMHS on May, 2011.

1 2 3

UK Research Scholarship Program Summer 2010 1- Alaa Sehamuddin Husain Galadari visited the laboratory of Professor Howard Morris at Imperial College. FMHS Research Supervisor – Professor Sehamuddin Galadari (Department of Biochemistry)

2- Salama Abdulbasit Al-Majed visited the laboratory of Professor Saadeh Suleiman at the Bristol Heart Institute, University of Bristol. FMHS Research Supervisor - Professor Chris Howarth (Department of Physiology)

Summer Research FMHS Laboratories 3- Mey Khalfan Al Ketbi working in the laboratory of Professor Ernest Adeghate (Department of Anatomy)

4- Salem Rashed Yammahi and Jasem Bani Shemaili working in the laboratory of Professor Tom Adrian (Department of Physiology) 4

131

Research Support

20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICALThe Analytical RESEARCH AT Services FMHS I 20 (Central YEARS OF Facilities) MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICALThe Electrophysiology RESEARCH AT FMHS I 20Centre YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICALThe Electron RESEARCH and AT FMHS Confocal I 20 YEARS Laser OF MicroscopyMEDICAL RESEARCH Imaging AT FMHS Unit I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICALThe Molecular RESEARCH AT Cellular FMHS I 20 Biology YEARS OF Facility MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICALThe National RESEARCH MedicalAT FMHS I Library20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS The Analytical Services (Central Facilities)

Central Facilities in the Faculty of Medicine, United Arab Emirates University (UAEU) managed by department of pharmacology under the directorship of Prof. Abdu Adem, is to cater the need of analytical requirements of various departments within the institution and other divisions of the UAEU. It had also rendered TFSWJDF
UP
FYUFSOBM
SFTFBSDI
PSHBOJTBUJPOT
JO
UFSNT
PG
SFTFBSDI
collaborations. Primarily the central facility in the Faculty of .FEJDJOF
JT
VTFE
FYUFOTJWFMZ
GPS
UIF
NFEJDBM
SFTFBSDI
BOE
BMTP
UP
UIF
SFRVJSFNFOU
PG
TUVEFOUT
MFBSOJOH
JO
UIFJS
TVNNFS
QSPKFDUT

Components of Central Facilities include :

t
)1-$
)JHI
1SFTTVSF
-JRVJE
$ISPNBUPHSBQIZ
t
*$1.4
*OEVDUJWFMZ
$PVQMFE
1MBTNB.BTT
TQFDUSPNFUSZ
t
($.4
(BT
$ISPNBUPHSBQIZ.BTT
4QFDUSPNFUSZ 

High Pressure Liquid Chromatography (HPLC)

Introduction HPLC is the sensitive analytical equipment which is used to iden- UJGZ
BOE
NFBTVSF
WBSJPVT
DIFNJDBMT
BOE
ESVHT
JO
UIF
NJYUVSFT
5IJT
JOTUSVNFOU
JT
BO
FYDFMMFOU
BOE
DPNNPOMZ
VTFE
JO
TFQBSBUJOH
the components of interest to its pure form in a given particular NJYUVSF
0VS
SFHVMBS
VTF
PG
UIF
FRVJQNFOU
JT
UP
TUVEZ
UIF
DPODFO- trations of the drug in the biological samples obtained during the SFTFBSDI
FYQFSJNFOUT
FJUIFS
GSPN
IVNBO
PS
BOJNBM
NPEFMT

On a regular basis, under the annual maintenance contracts, our NBDIJOFT
BSF
NBJOUBJOFE
CZ
UIF
GBDVMUZ
BOE
UIF
FYQFOEJUVSF
allotted through the central budget. However, the day to day run- ning costs for a given research projects are met by the end users. This unit used to collaborate with research organisations outside the University, and had in the past, generated funds which were later used for FMHS research activities.

134 The Analytical Services

Present Status: ally. Tissues can be digested in nitric acid and The following HPLC assays are run on a regular assayed. This instrument is ideal to estimate basis, by Departments of Pharmacology, Physi- trace elements and heavy metals. ology, Obstetrics and Gynaecology, Surgery, Paediatrics and Anatomy.

Estimations of 1- Catecholamines in plasma and animal tissues. 2- Rotenone in rat plasma 3- Antipyrene, Erythromycin and other antibiotics in the human placental perfusion model. 4- Vitamin C in rat blood plasma 
7JUBNJO
&
JO
SBU
CMPPE
QMBTNB
6- Analysis of Allantoin. 7- Analysis of Uric acid.

Method Development for antibiotics such as "NPYZDJMMJO
BOE
/PSøPYBDJO
XFSF
BMTP
CFFO
performed for quick and effective output. 3FTPVSDFT
BOE
UFDIOJDBM
FYQFSUJTF
BSF
BWBJMBCMF
for developing and validating methods for other applications on demand.

Gas Chromatograph Mass Spectrometer (GC-MS) A full scale GC-MS (Jeol) and a mini version of the GC-MS (HP) are available. The new one (Jeol) is commissioned, but not being used regularly. The mini version was used to run pesticide analysis, mostly. Currently it is being set up for organic acid analysis from biological samples. Operator level assistance is available for GC-MS, at the moment.

Inductively Coupled Plasma Mass Spectrometer (ICP-MS) ICP-MS is one of the most useful tools for trace element analysis. Detection sensitivity of ICP-MS is of the order of parts per billion (ppb). Current- ly equipped to handle aqueous samples and CJPMPHJDBM
TBNQMFT
UP
B
MJNJUFE
FYUFOU
#JPMPHJDBM
samples have to be treated and diluted manu-

135 The Electrophsyiology Centre

"O
A&MFDUSPQIZTJPMPHZ
$FOUSF
IBT
CFFO
SFDFOUMZ
FTUBCMJTIFE
in the Faculty of Medicine & Health Sciences. Establishing this centre has been the result of a collaborative initiative between colleagues in Physiology and Pharmacology Departments. The centre includes a wide range of facilities to conduct studies using in vivo biotelemetry, tissue culture, cell isolation, and in vitro elec- trophysiology. State-of-the art techniques such as isolated heart hemodynamic measurements, two-electrode voltage clamping in oocytes, patch clamping, and electrophysiological recordings from brain slices, dissocated cells and mammalian cell lines are routinely used in the center. An imaging facility for video edge motion detection and fluorescence photometry is also located within the facility. Ongoing research projects include investigations of the mecha- nisms that underlie cardiac muscle dysfunction in diabetic heart; actions of the endogenous cannabinoid neurotransmitter anandamide on the electrophysiology of cardiac myocytes; the effects of nanoparticles on electrophysiology of cardiac myo- cytes, effects of psychoactive drugs on various receptors and ion channels. Work in the centre is supported by technical staff, and by under- graduate medical students and graduate students in our PhD. and M.Sc. programs. The centre has ongoing research collabora- tions with various international research laboratories in U.S.A., Canada, U.K., Ukraine and other countries.

1 2 3

1-2. Lina Kury (Ph.D student) performing experiments using the patch clamp system and Dr Oleg Voitychuk (Post-doctoral scientist) visiting from Bogomoletz Institute of Physiology, Ukraine. 3. Anwar Qureshi (Technician) performing experiments using the video edge detection system

136 The Electron and Confocal Laser Microscopy Imaging Unit

The FMHS Imaging Unit provides electron microscopy service to For help please contact: a wide variety of individuals and organizations in FMHS, Faculty Dr. Safa Shehab, MBChB, PhD of Science & Engineering, UAEU, Tawam Hospital and Central Director of the image unit. Veterinary Research Laboratory, Dubai, UAE. This is the only trans- Associate Professor Department of Anatomy mission electron microscopy service in the UAEU, and possibly in Faculty of Medicine & Health the whole of the UAE. Sciences For this, we have two Philips CM10 transmission electron microscopes U.A.E. University and one Environmental Scanning Electron microscope, XL 30. P.O. Box 17666 In addition, we have recently acquired one confocal laser Scan- Al Ain, United Arab Emirates ning microscope, Nikon Eclipse C1. The Confocal Laser Scan- Tel : 00 971 3 7137186 ning Imaging System is a microscope that uses laser to visualize Fax : 00 971 3 7672033 fluorescent markers inside cells. The images are recorded directly e-mail: [email protected] into the hard drive of a computer that also controls the micro- or scope. This system is used by several members of FMHS in various Mr Said Tariq Image unit research disciplines. Tel : 00 971 3 7137186 The workload on the Imaging Unit is considerable and continues e-mail: [email protected] to increase.

2 3

1. A transmission electron micrograph of a heart muscle, showing cytoplasmic organelles including mitochondria, myofibrils and T tubules.

2. Scanning electron micrograph of the testis showing the sperms.

3. Confocal image of a section of the pancreas showing the cells of islet of Langerhans which contain insulin (green) and glucagon (blue). 1

137 The Molecular & Cellular Biology Facility

The Molecular & Cellular Biology Facility Unit at the FMHS supports investigators in their research endeavors by providing high quality services and access to state of the art technology. In this facility, located on the 4th floor (Block E) of the Faculty of medicine and Health Sciences (FMHS), the following equipment are available:

BD FACSCanto II (Fluorescence-Activated Cell Sorter) Real Time Quantitative PCR (Applied Biosystems) DNA Sequencing Image Analyzer System (Bio-Rad) FPLC (fast protein liquid chromatography) AKTA System Ultra Centrifuges (Beckman Coulter) High Speed Centrifuges (Beckman Coulter) Micro Analytical Balance Orbital Shakers (Thermo Scientific) NenoDrop Spectrofluorometer Spectrophotometers + general facilities equipment such as Autoclave, High Purity Ultra Milli-Q Water System, -80 Freezers, Cryo Storage Liquid Nitrogen Tanks, Cold Rooms, etc.

Currently at the FMHS Molecular & Cellular Biology Facility, we support the use of the flow cytometry, and other services such as the real time quantitative PCR and DNA sequencing are supported through investigators on the 4th floor. These include running TBNQMFT
JOTUSVNFOU
USBJOJOH
USPVCMFTIPPUJOH
BOE
FYQFSJNFOUBM
design.

BD FACSCanto II Recent technology acquired by the facility includes a BD FACS- Canto II. Flow cytometry is routinely used in the diagnosis of health disorders, especially blood cancers, but has many other applica- tions in both research and clinical practice including molecular biology, pathology, immunology, etc. It has broad application in medicine especially in transplantation, hematology, tumor im- munology and chemotherapy, genetics and sperm sorting. The '"$4$BOUP
**
GFBUVSFT
B
öYFEPQUJDT
EFTJHO
BOE
BEWBODFE
EJHJUBM
electronics to support multi-colour analyses of up to 8 fluorescent markers and two scattered parameters per assay with two lasers; blue and red and the instrument functions are controlled by BD FACS Diva software.

138 The National Medical Library (NML)

The NML staff has many reasons to be proud of itself for its Director achievements during 2010, not the least of which was suc- Ms. Marybeth Gaudette cessfully navigating the challenges of providing services to an Health Sciences Ref Librarian incoming student class more than twice the size of any previous Mr. Mohammed Salih classes. Solutions included dividing orientation into three cohort Circulation Librarians groups for both the male and female populations, having all staff Mr. Osama Kayal USBJOFE
UP
FYQMBJO
UIF
NPTU
QPQVMBS
SFTPVSDFT
BOE
FYQBOEJOH
Ms. Muna Hameed our electronic resources license agreements to allow access by an Catalogue Librarian unlimited number of users at any one time. M. Khurshid Iqbal Acquisition Librarian In order to keep the students aware throughout the year of Mr. Khalid Pasha resources that can assist them in their studies, the NML took on Document Delivery Librarian the challenge of integrating information literacy and library skills Mr. Abdul Salim into the course modules. At the beginning of each course and Library Technical Assistants module, NML staff demonstrated to students how to access and Mrs. Eben Prasad use resources applicable to the topic of the module. Mr. Abdurahiman Mr. Koya Kariyankandy NML met the challenge of serving the students enrolled in the '.)4T
TFWFSBM
OFX
1I%
BOE
.BTUFS
EFHSFF
QSPHSBNT
CZ
QVS- chasing a site license to Embase, a citation database particularly strong in the areas of pharmacology, biochemistry, and public IFBMUI
BSUJDMFT
JOEFYJOH

Another challenge to the NML has been to train faculty, students, and staff on how to effectively and efficiently use the numerous electronic resources that are increasingly replacing traditional printed resources. To that end, the NML staff undertook an inten- sive program of staff training on major e-resources during 2010. As a result, all NML staff members are now able to teach skills for FòFDUJWFMZ
VTJOH
1VC.FE
FCSBSZ
BOE
0WJE#PPLT
UP
UIF
-JCSBSZT
users. Several training sessions on those resources were offered throughout the year. Also introduced, and especially popu- MBS
XJUI
'.)4
GBDVMUZ
BOE
HSBEVBUF
TUVEFOUT
XFSF
UIF
/.-T
EndNote Web training session. For 2011, the goals are to have all staff trained to teach users how to search the Cochrane Library of Systematic Reviews and Embase.

As for individual staff achievement, the NML is very proud that our Interlibrary-Loan Librarian, Mr. Abdul Salim, was honored XJUI
POF
PG
UISFF
&NQMPZFFPGUIF:FBS
GPS
&YDFMMFODF
BXBSET
CZ
the Faculty of Medicine and Health Sciences.

139 The National Medical Library

Successful as 2010 was, it ended on a bitter- DFTT
UP
MJTUJOHT
PG
UIF
/.-T
FMFDUSPOJD
BOE
QSJOU
sweet note as the NML said good-bye to Mr. SFTPVSDFT
JT
BWBJMBCMF
GSFF
UP
BMM
WJB
UIF
/.-T
Altilathu Varughese Thomas, who retired in Web Site at http://nml.uaeu.ac.ae. During 2010, December to his family home in India. Mr. Tho- visitors, students, and faculty had access to over: mas gave the FMHS Faculty and students over 4.000 licensed electronic journals, 400 print twenty years of devoted service. While we regret KPVSOBMT
 
QSJOUFE
CPPLT
BOE
 
IFBMUI his leaving, we treasure his legacy of wisdom sciences and microbiology e-books and many contributions to the NML. Housed within the NML is the Learning Re- In February, 2011, the NML welcomed Dr. source Centre (LRC), whose two computer labs Muhammed Salih Thiyyakanidi to its staff as its can accommodate 31 users each and can be Health Sciences Reference Librarian. With 24 reserved for hands-on computer training. Two ZFBST
PG
MJCSBSZ
FYQFSJFODF
BOE
NBOZ
QVCMJ- more classrooms are equipped with state-of- cations to his credit, Dr. Salih specializes in the-art video equipment that allows broad- performing mediated searches for FMHS faculty. casting of lectures to linked facilities. There are His research areas of interest include digital also dedicated rooms set aside for multimedia- libraries, institutional repositories, and open- resources viewing, clinical-skills practice, and source applications. problem-based learning sessions. While the main floor is designed to be conducive to teach- Meeting its commitment as the National Medi- ing and collaborative learning, private study cal Library of the Emirates, the NML has avail- and quiet reading areas are available on the first BCMF
GPS
WJTJUPST
TJY
QVCMJDBDDFTT
DPNQVUFST
WJB
floor of the NML. XIJDI
BMM
UIF
/.-T
FMFDUSPOJD
SFTPVSDFT
DBO
CF
accessed. Visitors can also use within the NML any of its print and multimedia resources. Ac-

“An FMHS student captures the moment when Mr. Thomas cuts the first slice in the cake baked in his honor to celebrate his 20-plus years of service to the NML and the FMHS.”

“His fellow NML male staff members gather with Mr. Thomas at the NML Farewell Open House held in his honor in December. Pictured from left to right are Mr. Khurshid Iqbal, Mr. Abdul Salim, Mr. Ahmed Fathy, Mr. A. V. Thomas, Mr. Osama Kayal, Mr. Pattarathil Abdulrahiman, Mr. Koya Kariankandy, and Mr. Khalid Pasha. Not shown are NML staff members, Mrs. Widad El Jaily, Mrs. Eben A. Prasad, Mrs. Mona Abdul Hameed, Dr. Muhammed Salih, and NML Director, Ms. Marybeth Gaudette”

140 Impact Factor

YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 Impact Factor

Impact Factor

Jornal Impact Factor Jornal Impact Factor Cell 31.152 Reprod Toxicol 3.367 Cancer Cell 25.288 Neuroscience 3.292 Brit Med J 13.660 Immunology 3.276 PLoS Med 13.050 Adv Anat Pathol 3.221 Am J Hum Genet 12.303 Mol Immunol 3.202 Nat Struct Mol Biol 12.273 Mini Rev Med Chem 2.971 Brain 9.490 Brit J Urology Intl 2.865 Proc Natl Acad Sci USA 9.432 J Neuroimmunol 2.841 Neurology 8.172 BMC Med Genet 2.840 Stem Cells 7.747 Bioorgan Med Chem 2.822 Hum Mol Genet 7.386 Pancreas 2.733 Arthritis Rheum 7.332 Peptides 2.705 Hum Mutat 6.887 Med Educ 2.696 Diabetes Care 6.718 Horm Metab Res 2.686 Allergy 6.380 Ann NY Acad Sci 2.670 J Med Genet 5.751 Exp Biol Med 2.635 J Biol Chem 5.328 J Trauma 2.626 AIDS 4.909 Eur J Pharmacol 2.585 Toxicol Sci 4.814 Comp Biochem Phys C 2.582 J Med Chem 4.802 Biochem Biophys Res Commun 2.548 Endocrinology 4.752 Int Arch Allergy Immunol 2.542 Curr Med Chem 4.708 Int Urogynecol J Pelvic Floor 2.412 Am J Public Health 4.371 Dysfunct J Clin Microbiol 4.162 Histol Histopathol 2.404 J Pharmacol Exp Ther 4.093 Injury 2.383 J Urology 4.016 Trop Med Int Health 2.328 J Neurochem 3.999 J Gastroenterol Hepatol 2.317 J Mol Biol 3.871 Cell Tissue Res 2.308 Histopathology 3.855 Virchows Arch 2.305 Chem Res. Toxicol 3.740 Vet Parasitol 2.278 Front Biosci 3.736 BMC Public Health 2.223 J Inherit Metab Dis 3.598 J Pediatr Gastrenterol Nutr 2.183 Neurogastroenterol Motil 3.568 Regul Pept 2.160 Anal Bioanal Chem 3.480 Pediatr Blood Cancer 2.134 Toxicol Lett 3.479 Toxicon 2.128 Int J Cardiol 3.469 Food Chem Toxicol 2.114 J Mass Spectrom 3.411 J Diabetes Complicat 2.110 Int Immunol 3.403 Bri J Radiol 2.105

142 Impact Factor

Jornal Impact Factor Jornal Impact Factor World J Gastroenterol 2.092 Biochem Biophys Acta - J Appl Toxicol 2.073 BMC Med Educ - J Biomed Sci 2.007 BMC Res Notes - Microb Drug Resist 1.989 Case Report Med - Int J Geriatr Psychiatry 1.981 Crisis - Respiration 1.935 East Mediterr Health J - J Comp Physiol B 1.897 Education for Health - Mol Cell Biochem 1.896 Head Neck Pathol - Pharmacology 1.833 Health Soc Care Community - J Arthroplasty 1.787 Ibnosina J Med Biomed Sci - J Endourol 1.754 Int J Global Harmony - J Perinat Med 1.736 Int J Health Care Qual Assur - BMC Health Serv Res 1.660 Int J Surgery - Lung 1.583 Int Psych J - Fam Pract 1.515 J Community Genetics - Rheumatol Int 1.493 J Infect Public Health - Anat Rec 1.490 J Immunopathol & Pharmacol - Urol Res 1.465 J Islamic Med Assoc of North - Physiol Res 1.430 America Anticancer Res 1.428 J Med Sci - J Matern Fetal Neo M 1.362 J Pediatr Sci - Med Teach 1.333 J Pers Disord - Int J Toxicol 1.243 J Pharmacol Toxicol Method - Pediatr Cardiol 1.151 Learning & Teaching in Higher - Biomed Res 1.146 Education: Gulf Perspectives Comput Methods Programs Biomed 1.144 Methods Mol Biol - Nutr Neurosci 1.143 Open Inf Dis J - Ann Hum Biol 1.064 Pathophysiology - Int Urol Nephrol 1.053 Public Health Genomics - Arch Gynecol Obstet 0.912 Saudi J Kidney Dis & Transpl - Biomark Med 0.861 Scoliosis - Asia Pacific J Pub Health 0.763 SHAMS J Med Sci - Eur J Emerg Med 0.733 Singapore Med J - J Obstet Gynaecol 0.431 South Afr J Epidemiol Infect - ACS Med Chem Lett - Turk J Trauma Emerg Surg - Addictive Disorder & Their Treatment - World J Emerg Surg - Am J Drug Alcohol Abuse - Arab Health -

143

YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 ﻣﻌﻬﺪ ﺟﺎﻣﻌﺔ ﺍﻹﻣﺎﺭﺍﺕ ﻟﻠﺼﺤﺔ ﺍﻟﻌﺎﻣﺔ



ﺍﺳﺘﻀﺎﻓﺔ ﺟﺎﻣﻌﺔ ﺍﻹﻣﺎﺭﺍﺕ ﺍﻟﻌﺮﺑﻴﺔ ﺍﻟﻤﺘﺤﺪﺓ ﻓﻲ ﺷﻬﺮ ﻳﻨﺎﻳﺮ ﺍﻟﻤﺎﺿﻲ ٢٠١٠ ﻣﺆﺗﻤﺮ ٠١٠ ٢ ﺍﻟﺼﺤﺔ ﺍﻟﻌﺎﻟﻤﻴﺔ ﻭﺍﻹﻣﺎﺭﺍﺕ: ﺁﺳﻴﺎ ﻭﺭﺍﺑﻄﺔ ﺍﻟﺸﺮﻕ ﺍﻷﻭﺳﻂ ﻭﺍﻟﺬﻱ ﻳﻌﺪ ﻣﺆﺗﻤﺮﺍ ﻓﺮﻳﺪ ﻣﻦ ﻧﻮﻋﻪ ﺣﻴﺚ ﻧﺎﻗﺸﺖ ﺍﻟﻮﻓﻮﺩ ﺍﻟﻤﺸﺎﺭﻛﺔ ﻣﺸﺎﻛﻞ ﺍﻟﺼﺤﺔ ﺍﻟﻌﺎﻟﻤﻴﺔ ﺍﻟﺘﻲ ﻇﻬﺮﺕ ﻋﻨﺪ ﺍﻛﺘﺸﺎﻑ « ﻃﺮﻳﻖ ﺍﻟﺤﺮﻳﺮ ﺍﻟﺠﺪﻳﺪ « ﺍﻟﺬﻱ ﻳﺮﺑﻂ ﺑﻴﻦ ﺍﻟﻤﺪﻥ ﺍﻟﻌﺎﻟﻤﻴﺔ ﻟﺪﻭﻟﺔ ﺍﻹﻣﺎﺭﺍﺕ .ﻭﺍﻟﺸﺮﻕ ﺍﻷﻭﺳﻂ ﻣﻊ ﻣﻮﻣﺒﺎﻱ ﻭﻛﻮﺍﻻﻟﻤﺒﻮﺭ ﻭﺳﻨﻐﺎﻓﻮﺭﺓ ﻭﺷﻨﻐﻬﺎﻱ ﻭﻫﻮﻧﺞ ﻛﻮﻧﺞ ﻭﻓﻲ ﺧﺘﺎﻡ ﺍﻟﻤﺆﺗﻤﺮ ﺗﻢ ﻭﺿﻊ ﺍﻷﺳﺲ ﻟﻤﻌﻬﺪ ﺍﻟﺼﺤﺔ ﺍﻟﻌﺎﻟﻤﻴﺔ ﻛﻤﺤﻮﺭ ﺭﺋﻴﺴﻲ ﻓﻲ ﺍﻟﺸﺒﻜﺔ ﺍﻟﻌﺎﻟﻤﻴﺔ، ﻭﺗﻌﺘﺒﺮ ﺟﺎﻣﻌﺔ ﺍﻹﻣﺎﺭﺍﺕ ﺍﻟﻌﺮﺑﻴﺔ ﺍﻟﻤﺘﺤﺪﺓ ﺍﻟﻤﻜﺎﻥ ﺍﻟﻤﺜﺎﻟﻲ ﻻﺳﺘﻀﺎﻓﺔ ﻭﺗﺄﺳﻴﺲ ﻫﺬﺍ ﺍﻟﻤﻌﻬﺪ ﺍﻟﺠﺪﻳﺪ ﻋﻠﻰ ﺃﺭﺿﻬﺎ، ﺣﻴﺚ ﺃﻧﻬﺎ ﺳﺘﺒﺪﺃ ﺑﺘﻌﻴﻴﻦ ﺧﺒﺮﺍﺀ ﻭﻋﻠﻤﺎﺀ ﻟﺒﺤﺚ .ﺍﻟﻘﻀﺎﻳﺎ ﺍﻟﺼﺤﻴﺔ ﺍﻟﺘﻲ ﺗﻮﺍﺟﻪ ﺍﻷﻣﺔ ﻭﺍﻟﻤﻨﻄﻘﺔ ﻋﻠﻰ ﻧﻄﺎﻕ ﺃﻭﺳﻊ

ﻭﻣﻦ ﺃﻫﻢ ﻣﺠﺎﻻﺕ ﺍﻟﺒﺤﺚ ﺍﻟﺮﺋﻴﺴﻴﺔ ﻟﻠﻤﻌﻬﺪ ﻫﻲ ﺻﺤﺔ ﺍﻟﺴﻜﺎﻥ ﻭﺧﺎﺻﺔ ﺃﻧﻤﺎﻁ ﻭﻋﻮﺍﻣﻞ ﺧﻄﺮ ﻣﺮﺽ ﺍﻟﺴﻜﺮﻱ ﻭﺃﻣﺮﺍﺽ ﺍﻟﻘﻠﺐ ﻭﺍﻷﻭﻋﻴﺔ ﺍﻟﺪﻣﻮﻳﺔ ﻭﺍﻻﺿﻄﺮﺍﺑﺎﺕ ﺍﻟﻮﺭﺍﺛﻴﺔ ﻭﺍﻹﺻﺎﺑﺎﺕ، ﻭﺑﺎﻹﺿﺎﻓﺔ ﻟﻠﻌﻮﺍﻣﻞ ﺍﻻﺟﺘﻤﺎﻋﻴﺔ ﻭﺍﻷﺳﺮﻳﺔ ﺍﻟﺘﻲ ﺗﺆﺛﺮ ﻋﻠﻰ ﺍﻟﺴﻠﻮﻙ ﺍﻟﺼﺤﻲ ﻭﺻﺤﺔ ﺍﻟﻤﻬﺎﺟﺮﻳﻦ ﻭﺍﻷﻣﺮﺍﺽ ﺍﻟﻮﺑﺎﺋﻴﺔ ﻭﺍﻟﻤﺘﻌﻠﻘﺔ ﺑﺎﻟﺴﻔﺮ ﻭﺍﻟﺼﺤﺔ ﺍﻟﺒﺪﻧﻴﺔ ﻭﺍﻟﻌﻘﻠﻴﺔ .ﻟﻼﺟﺌﻴﻦ ﻭﺍﻟﺘﺤﺪﻳﺎﺕ ﺍﻟﺘﻲ ﺗﻮﺍﺟﻪ ﻧﻈﻢ ﺍﻟﺼﺤﺔ ﺍﻟﻤﺤﻠﻴﺔ ﻭﺣﺎﻟﻴﺎ ﻳﺴﻌﻰ ﺍﻟﻤﻌﻬﺪ ﺟﺎﻫﺪﺍ ﻓﻲ ﺍﻟﺒﺤﺚ ﻋﻠﻰ ﺭﻋﺎﻳﺔ ﻭﺗﺄﺳﻴﺲ ﻭﻇﻴﻔﺔ ﺟﺪﻳﺪﺓ ﻓﻲ ﺍﻟﻜﻠﻴﺔ ﻟﻌﻠﻢ ﺍﻻﺛﻨﻮﻏﺮﺍﻓﻴﺎ ﻭﺍﺳﺘﻜﺸﺎﻑ ﺍﻟﺮﻭﺍﺑﻂ ﺍﻟﺪﻭﻟﻴﺔ، ﺣﻴﺚ ﻗﺎﻡ ﺍﻟﻤﻌﻬﺪ ﺑﺘﻤﻮﻳﻞ ﻣﺸﺮﻭﻋﻴﻦ ﺃﺳﺎﺳﻴﻴﻦ ﻟﻠﺒﺤﻮﺙ ﻛﻤﺎ ﻭﺍﻓﻖ ﺍﻟﺴﻴﺪ ﺭﻳﺘﺸﺎﺭﺩ ﻓﻴﺸﻢ ﺃﺳﺘﺎﺫ ﺍﻟﺼﺤﺔ ﺍﻟﻌﺎﻟﻤﻴﺔ ﺑﺠﺎﻣﻌﺔ ﻛﺎﻟﻴﻔﻮﺭﻧﻴﺎ ﻋﻠﻰ ﺍﻟﻌﻤﻞ ﺑﺠﺎﻧﺐ ﺟﺎﻣﻌﺔ ﺍﻹﻣﺎﺭﺍﺕ ﺍﻟﻌﺮﺑﻴﺔ ﺍﻟﻤﺘﺤﺪﺓ ﻭﺍﻟﻤﺴﺎﻋﺪﺓ ﻓﻲ ﺗﺄﺳﻴﺲ . ﺍﻟﻤﻌﻬﺪ ﻋﻠﻰ ﻣﺪﻯ ﺍﻟﺜﻼﺙ ﺳﻨﻮﺍﺕ ﺍﻟﻤﻘﺒﻠﺔ

ﻳﺮﺣﺐ ﺍﻟﻤﻌﻬﺪ ﺑﺠﻤﻴﻊ ﺃﻋﻀﺎﺀ ﻫﻴﺌﺔ ﺍﻟﺘﺪﺭﻳﺲ ﻭﺍﻟﻤﻮﻇﻔﻴﻦ ﻓﻲ ﺟﺎﻣﻌﺔ ﺍﻹﻣﺎﺭﺍﺕ ﻭﻛﻠﻴﺔ ﺍﻟﻄﺐ ﺑﺎﻹﺿﺎﻓﺔ ﺇﻟﻰ ﺍﻟﻤﻬﺘﻤﻴﻦ ﺑﺎﻟﺼﺤﺔ ﺍﻟﻌﺎﻟﻤﻴﺔ ﻟﻠﻤﺴﺎﻫﻤﺔ ﻓﻲ ﻋﻤﻞ ﺍﻟﻤﻌﻬﺪ ﻟﻜﻲ ﻳﺼﺒﺤﻮﺍ ﺷﺮﻛﺎﺀ ﺗﺎﺑﻌﺔ ﻟﻪ. ﻭﻣﺎﺯﺍﻝ ﺍﻟﻤﻮﻗﻊ ﺍﻻﻟﻜﺘﺮﻭﻧﻲ ﻟﻠﻤﻌﻬﺪ ﻗﻴﺪ ﺍﻹﻧﺸﺎﺀ (www.fmhs.uaeu.ac.ae/globalhealth) ﻭﻟﻠﻤﺰﻳﺪ ﻣﻦ ﺍﻟﻤﻌﻠﻮﻣﺎﺕ ﻳﺮﺟﻰ ﺍﻟﺘﻮﺍﺻﻞ ﻣﻊ ﺍﻟﺪﻛﺘﻮﺭ ﺍﻳﺎﻥ ﺑﻠﻴﺮ، ﺍﻷﺳﺘﺎﺫ ﺍﻟﻤﺸﺎﺭﻙ ﺑﻘﺴﻢ ﻃﺐ ﺍﻟﻤﺠﺘﻤﻊ ﺑﻜﻠﻴﺔ ﺍﻟﻄﺐ ﻭﺍﻟﻌﻠﻮﻡ ﺍﻟﺼﺤﻴﺔ ([email protected])

ﻛﻠﻤﺔ ﺍﻟﻌﻤﻴﺪ

ﺍ ﻧﻪ ﺍﻭﺩﻟﻤﻦ ﺃﻥﺃﻱﺭﻭﺳﺮﻋﻲ ﻳﺪﺃﺑﻴﻦﺿﻊ ﻣﻘﺪﻳﻜﻢ ﻣﺔ ﻃﺒﻌﺔ 2010 ﺻﺔﻟﺨﺎﺍ ﺑﺤﺎﻷﺑﺎ ﺍﺙ ﺍﻟﻜﻠﻴﺔﻟﻌﻠﻤﻴﺔ .ﻟﺼﺤﻴﺔﺍﻡﻟﻌﻠﻮﺍﻭﻟﻄﺐ ﺍﻟﻜﻠﻴﺔﻟﻌﻠﻤﻴﺔ ﺍﺙ ﺑﺤﺎﻷﺑﺎ

ﺃﻟﻄﺒﻌﺔﺍهﻟﻬﺬ ﺧﺎﻫﻤﻴﻪ ﺻﺔ ﻟﻀﻮﺍﺳﺘﻠﻘﻲﺣﻴﺚ ﻥﻭﻟﻌﺸﺮﺍﺕﺍﺭﺍﺻﺪﻹﺍﻋﻠﻰﺀ ﻟﻀﻮﺍﺳﺘﻠﻘﻲﺣﻴﺚ ﺻﺔ ﺧﺎﻫﻤﻴﻪ ﺃﻟﻄﺒﻌﺔﺍهﻟﻬﺬ ﻟﺴﺎﺍ ﺍﻟﻠﺒﺤﺚﺑﻘﺔ ﺃﻛﻤﺎﻟﻌﻠﻤﻲ ﺃﺗﺸﻜﻞﻧﻬﺎ ﻫﻤﻴﺔ ﻟﻌﻠﻤﻲﺍﺝﻧﺘﺎﻹﺍﻓﻲﺣﻘﻴﻘﺔ ﻫﻤﻴﺔ ﺃﺗﺸﻜﻞﻧﻬﺎ ﺃﻛﻤﺎﻟﻌﻠﻤﻲ ﺍﻟﻠﺒﺤﺚﺑﻘﺔ ﻟﺴﺎﺍ ﺍﻟﻤﺴﺘﻤﺮ ﺍﻟﻜﻠﻴﺔ ﻟﺼﺤﻴﺔﺍﻡﻟﻌﻠﻮﺍﻭﻟﻄﺐ ﺃﻭ، ﺃﻱﺭﻭﺑﺪﻧﺎ ﺀﻋﻀﺎﺃﺟﻤﻴﻊﻫﻨﺊ ﺃﻱﺭﻭﺑﺪﻧﺎ ﺃﻭ، ﻟﺼﺤﻴﺔﺍﻡﻟﻌﻠﻮﺍﻭﻟﻄﺐ ﺍﻟﻜﻠﻴﺔ ﻟﺬﺍﻳﺲﺭﻟﺘﺪﺍﻫﻴﺌﺔ ﺍﺟﻴﺔﻧﺘﺎﻹﺍﺀﺍﺛﺮﺇﻓﻲﺍﻫﻤﻮﺳﺎﻳﻦ ﺻﻮﻭﻭﻟﺒﺤﺜﻴﺔ ﻋﻠﻰﻷﻟﻬﺎ ﺻﻮﻭﻭﻟﺒﺤﺜﻴﺔ ﺍﺟﻴﺔﻧﺘﺎﻹﺍﺀﺍﺛﺮﺇﻓﻲﺍﻫﻤﻮﺳﺎﻳﻦ ﻟﺬﺍﻳﺲﺭﻟﺘﺪﺍﻫﻴﺌﺔ .ﺕﻳﺎﻟﻤﺴﺘﻮﺍ ﻟﻔﺮﺍﻏﺘﻨﻢﺍﻛﻤﺎ ﻟﺒﺎﺍﺷﻜﺮﻷﺻﺔ ﻭﻟﺘﻌﺎﺑﺎﺣﺜﻴﻦ ﻥ ﺕﺳﺎﺍﺭﻟﺪﺍﺏﻃﻼﻣﻊ ﻥ ﻭﻟﺘﻌﺎﺑﺎﺣﺜﻴﻦ ﻟﺒﺎﺍﺷﻜﺮﻷﺻﺔ ﻟﻔﺮﺍﻏﺘﻨﻢﺍﻛﻤﺎ .ﺕﻳﺎﻟﻤﺴﺘﻮﺍ ﺍ ﺍﺏﻃﻼﻭﻟﻌﻠﻴﺎ ﺍﻭﻟﻄﺐ ﻟﻔﻨﻴﻴﻦ ﻣﻮﻗﺪﻟﻤﺎ ه ﻫﻤﺎﻣﺴﺎﻣﻦ ﻫﺎﺕ ﻡﻟﻌﻠﻮﺍﻓﻲﻣﺔ ﻫﺎﺕ ﻫﻤﺎﻣﺴﺎﻣﻦ ه ﻣﻮﻗﺪﻟﻤﺎ ﻟﻔﻨﻴﻴﻦ ﺍﻭﻟﻄﺐ ﺍﺏﻃﻼﻭﻟﻌﻠﻴﺎ ﺍ ﻳﺮﻟﺴﺮﺍ ﺍﻡﻟﺘﻘﺪﺍﻭﻳﺔ ﺍﻟﺼﻌﻴﺪﺍﻋﻠﻰﻟﻌﻠﻤﻲ .ﻟﻲﻭﻟﺪﺍﻭﻟﻤﺤﻠﻲ ﺃﺣﻴﺚ ﻧﻴﻬﻢﺗﻔﺎﻥ ﺃﺣﻴﺚ .ﻟﻲﻭﻟﺪﺍﻭﻟﻤﺤﻠﻲ ﺍﻟﺼﻌﻴﺪﺍﻋﻠﻰﻟﻌﻠﻤﻲ ﺍﻡﻟﺘﻘﺪﺍﻭﻳﺔ ﻳﺮﻟﺴﺮﺍ ﺍﻟﻤﺘﻮﺍ ﻧﺘﺎﺇﻭﺻﻞ ﺟﻬﻢ ﺑﻘﺎﻳﻜﻔﻞ ﺍﻛﻠﻴﺔﺀ ﻟﻄﺐ ﻣﻮﻟﻤﺮﺍﻧﺘﻬﺎﻣﻜﺎﻓﻲ ﻣﻦﻗﺔ ﺣﻴﺚ ﻣﻦﻗﺔ ﻣﻮﻟﻤﺮﺍﻧﺘﻬﺎﻣﻜﺎﻓﻲ ﻟﻄﺐ ﺍﻛﻠﻴﺔﺀ ﺑﻘﺎﻳﻜﻔﻞ ﺟﻬﻢ ﻧﺘﺎﺇﻭﺻﻞ ﺍﻟﻤﺘﻮﺍ ﻟﺒﺤﻮﺍﺕﺍﺯﻧﺠﺎﺍ ﺙ .ﺿﻴﻴﻦﻟﻤﺎﺍﻳﻦﻟﻌﻘﺪﺍﻯﻣﺪﻋﻠﻰ ﺙ ﻟﺒﺤﻮﺍﺕﺍﺯﻧﺠﺎﺍ

ﻣﺆﻳﻌﺪ ﺟﺎﺗﻤﺮ ﻟﻌﺎﺍﻟﺼﺤﺔﺍ”ﺓﻟﻤﺘﺤﺪﺍﺑﻴﺔﻟﻌﺮﺍﺕﺍﺭﻣﺎﻹﺍﻣﻌﺔ ﺳﻴﺎﺃ:ﺕﺍﺭﻣﺎﻹﺍﻭﻟﻤﻴﺔ ﻟﻌﺎﺍﻟﺼﺤﺔﺍ”ﺓﻟﻤﺘﺤﺪﺍﺑﻴﺔﻟﻌﺮﺍﺕﺍﺭﻣﺎﻹﺍﻣﻌﺔ ﺟﺎﺗﻤﺮ ﻣﺆﻳﻌﺪ “ﺳﻂﻭﻷﺍﻕﻟﺸﺮﺍﺑﻄﺔﺍﺭﻭ ﺍﺣﺪﺃﺯﺑﺮﺍﻣﻦ ﻋﺎﺙ ﻡ 2010 ﻟﺬﺍﻭ ﺀﻟﻀﻮﺍﺳﻠﻂﻱ ﻋﻠﻰ ﺀﻟﻀﻮﺍﺳﻠﻂﻱ ﻟﺬﺍﻭ ﺗﺞﻟﻨﺎﺍﻱﻟﻔﻜﺮﺍﻝﺩﻟﺘﺒﺎﺍﻭﻑﺍﻋﺮﻷﺍﻭﺏﻟﺸﻌﻮﺍﻑﺧﺘﻼﺍ ﻋﻦ ﺗﺞﻟﻨﺎﺍﻱﻟﻔﻜﺮﺍﻝﺩﻟﺘﺒﺎﺍﻭﻑﺍﻋﺮﻷﺍﻭﺏﻟﺸﻌﻮﺍﻑﺧﺘﻼﺍ ﻟﻬﺎﺍﻉﺗﻔﺎﺭﻻﺍ ﺋﻞ ﻟﺴﻜﺎﺍﺩﻋﺪﻓﻲ ﻥ ﺇﻱﺩﻳﺆﻣﻤﺎ ﺗﻔﺎﻟﻰ ﻣﺸﺎﻗﻢ ﻛﻞ ﻟﻤﻴﺔﻋﺎﺻﺤﻴﺔ ﻛﻞ ﻣﺸﺎﻗﻢ ﺗﻔﺎﻟﻰ ﺇﻱﺩﻳﺆﻣﻤﺎ ﻥ ﻟﺴﻜﺎﺍﺩﻋﺪﻓﻲ ﺋﻞ ﻟﻬﺎﺍﻉﺗﻔﺎﺭﻻﺍ ﺓﻳﺪﺟﺪ ، ﺳﺎﻓﻘﺪ ﺗﺄﻭﺡﻧﺠﺎﻫﻢ ﺇﺗﻤﺮﻟﻤﺆﺍﺍﻫﺬﺛﻴﺮ ﺩﻻﻭﻟﻰ ﺓ ﻓﻜﺎﺃﻭﺧﻄﻂ ﺀﻧﺸﺎﻹﺭ ﻓﻜﺎﺃﻭﺧﻄﻂ ﺓ ﺩﻻﻭﻟﻰ ﺇﺗﻤﺮﻟﻤﺆﺍﺍﻫﺬﺛﻴﺮ ﺗﺄﻭﺡﻧﺠﺎﻫﻢ ﺳﺎﻓﻘﺪ ، ﺓﻳﺪﺟﺪ ﻟﻌﺎﺍﻟﺼﺤﺔﺍﻣﻌﻬﺪ ﻟﺬﺍﻭﻟﻤﻴﺔ ﻻﻣﺠﺎﻛﺰﺳﺘﺘﻤﺮﻱ ﻟﺮﺍﺑﺤﺜﻪﺕ ﻝﺣﻮﺋﻴﺴﻴﺔ ﺻﺤﺔ ﻝﺣﻮﺋﻴﺴﻴﺔ ﻟﺮﺍﺑﺤﺜﻪﺕ ﻻﻣﺠﺎﻛﺰﺳﺘﺘﻤﺮﻱ ﻟﺬﺍﻭﻟﻤﻴﺔ ﻟﻌﺎﺍﻟﺼﺤﺔﺍﻣﻌﻬﺪ ﻟﺒﺪﺍﻥﻟﺴﻜﺎﺍ ﺍﻭﻧﻴﺔ ﻟﻌﻘﻠﻴﺔ ﺍﻋﻮﻭﻁﻧﻤﺎﺃﻟﺘﺸﻤﻞ ﺓﺻﺮﻟﻤﻌﺎﺍﺽﺍﻣﺮﻷﺍﺧﻄﺮﻣﻞ ﺍﻋﻮﻭﻁﻧﻤﺎﺃﻟﺘ ﺸﻤﻞ .ﺋﻴﺔﺑﺎﻟﻮﺍﻭ ﻛﻤﺎ ﺟﻬﻮﺗﺴﺘﻤﺮ ﺍﺭﻣﺎﻹﺍﻣﻌﺔﺟﺎﺩ ﺕ ﻗﺎﺣﻴﺚ ﻛﺘﻮﻟﺪﺍﺑﺘﻌﻴﻴﻦﻣﺖ ﻳﻦﻻﺭ ﻛﺘﻮﻟﺪﺍﺑﺘﻌﻴﻴﻦﻣﺖ ﻗﺎﺣﻴﺚ ﺕ ﺍﺭﻣﺎﻹﺍﻣﻌﺔﺟﺎﺩ ﺟﻬﻮﺗﺴﺘﻤﺮ ﻛﻤﺎ .ﺋﻴﺔﺑﺎﻟﻮﺍﻭ ﺍﺑﺮ ﺭﻟﺘﺪﺍﻟﻬﻴﺌﺔﺍﻋﻀﻮﻳﻦ ﻳﺴﻴﺔ ﺍﻃﺐﺑﻘﺴﻢ ﻟﻤﺠﺘﻤﻊ ﺍﺑﻜﻠﻴﺔ ﻡﻟﻌﻠﻮﺍﻭﻟﻄﺐ ﺍﺑﻜﻠﻴﺔ ﺍ ﻛﺮﻟﺼﺤﻴﺔ ﻣﺆﺋﻴﺲ .ﻟﻤﻲﻟﻌﺎﺍﻟﺼﺤﺔﺍﻟﻤﻌﻬﺪﻗﺖ ﻣﺆﺋﻴﺲ ﻛﺮﻟﺼﺤﻴﺔ ﺍ

ﺗﻘﺪ ﺍﻳﺔﻟﻮﻭﻷﺍﺕﻋﺎﻣﺠﻤﻮﻡ ﺍﺑﻜﻠﻴﺔﻟﺒﺤﺜﻴﺔ ﺍﻡﻟﻌﻠﻮﺍﻭﻟﻄﺐ ﺍﻓﺰﺣﺎﻟﺼﺤﻴﺔ ﺍﻡﻟﻌﻠﻮﺍﻭﻟﻄﺐ ﺍﺑﻜﻠﻴﺔﻟﺒﺤﺜﻴﺔ ﺍﻳﺔﻟﻮﻭﻷﺍﺕﻋﺎﻣﺠﻤﻮﻡ ﺗﻘﺪ ﺍﻟﻠﻤﺠﺘﻤﻊ ﻟﻌﻠﻤﻲ ﺍﺭﻣﺎﻹﺍﻟﺔﻭﺩﻓﻲ ﻭﺕ ﺍﺫﻫﻲ ﺕ ﻛﺒﻴﺮﺻﻠﺔ ﻟﺼﺤﻴﺔﺍﻳﺎﻟﻘﻀﺎﺑﺎﺓ ﻛﺒﻴﺮﺻﻠﺔ ﺕ ﺍﺫﻫﻲ ﻭﺕ ﺍﺭﻣﺎﻹﺍﻟﺔﻭﺩﻓﻲ ﻟﻌﻠﻤﻲ ﺍﻟﻠﻤﺠﺘﻤﻊ ﻭﻟﺪﺍﻓﻲ ﺃﺣﻴﺚﻟﺔ ﺗﻘﻮﻧﻬﺎ ﺍﻟﺼﺤﻴﺔﺍﻳﺎﻟﻘﻀﺎﺍﻟﺠﺔﺑﻤﻌﺎﻡ ﻣﺔﻷﺍﻕﺭﺗﺆﻟﺘﻲ ﻓﻲ ﻣﺔﻷﺍﻕﺭﺗﺆﻟﺘﻲ ﺍﻟﺼﺤﻴﺔﺍﻳﺎﻟﻘﻀﺎﺍﻟﺠﺔﺑﻤﻌﺎﻡ ﺗﻘﻮﻧﻬﺎ ﺃﺣﻴﺚﻟﺔ ﻭﻟﺪﺍﻓﻲ ﺍﺭﻟﻮﺍﺽﺍﻣﺮﺃ:ﻟﻴﺔﻟﺘﺎﺍﺕﻻﻟﻤﺠﺎﺍ ﻡﻟﻌﻠﻮﺍﻭ،ﻡﺍﺭﻭﻷﺍﻭ،ﺕﺑﺎﺻﺎﻹﺍﻭ،ﻟﻨﻤﻮﺍﻭﺛﺔ ﺍﺭﻟﻮﺍﺽﺍﻣﺮﺃ:ﻟﻴﺔﻟﺘﺎﺍﺕﻻﻟﻤﺠﺎﺍ ﻟﻤﻨﺎﺍﻭ،ﻟﻌﺼﺒﻴﺔﺍ ﺍﺽﺍﻣﺮﺃﻭﻱﻟﺴﻜﺮﺍﻭ،ﻯﻭﻟﻌﺪﺍﻭﻋﺔ ﻳﺔﻣﻮﻟﺪﺍﻋﻴﺔﻭﻷﺍﻭﻟﻘﻠﺐ ﺍﺽﺍﻣﺮﺃﻭﻱﻟﺴﻜﺮﺍﻭ،ﻯﻭﻟﻌﺪﺍﻭﻋﺔ ﻟﻤﻨﺎﺍﻭ،ﻟﻌﺼﺒﻴﺔﺍ .ﻟﻄﺒﻲﺍﻟﺘﻌﻠﻴﻢﺍﻭ

ﺃﺩﻧﻮ ﻧﻌﺮﻥ ﻣﺘﻨﺎﺍﻋﻦﺏ ﻟﺸﺪﺍﻧﻨﺎﻓﺎﻋﺮﻭﻧﻨﺎ ﺫﻭﺓﻋﺎﻟﻠﺮﻳﺪ ﻳﺔﻋﺎﻟﺮﺍﻳﻢﻟﺘﻘﺪﻟﻚ ﺫﻭﺓﻋﺎﻟﻠﺮﻳﺪ ﻟﺸﺪﺍﻧﻨﺎﻓﺎﻋﺮﻭﻧﻨﺎ ﻣﺘﻨﺎﺍﻋﻦﺏ ﻧﻌﺮﻥ ﺃﺩﻧﻮ ﺍﻟﻤﺘﻮﺍ ﻟﺪﺍﻭﺻﻠﺔ ﺛﻨﺎﺑﺤﺎﻷﻋﻢ ﻟﺪﺍﻭﺻﻠﺔ ﺍﻟﻤﺘﻮﺍ :ﻫﻢﻭ :ﻫﻢﻭ • ﺍﺓﺋﺰﺟﺎ ﺍﺣﻤﺪﻟﺸﻴﺦ ﻟﻄﺒﻴﺔﺍﻡﻟﻠﻌﻠﻮﻥ ﺍﺣﻤﺪﻟﺸﻴﺦ ﺍﺓﺋﺰﺟﺎ • • ﻭﺻﻨﺪ ﺗﻴﺮﻕ ﻃﺎﻟﻠﺴﺮﻱ ﻥ ﺩﻓﻲ ﺑﻮﺍﻭﺑﻲ ﺍﻛﻨﺪﻭﻇﺒﻲ ﺑﻮﺍﻭﺑﻲ ﺩﻓﻲ ﻥ ﻃﺎﻟﻠﺴﺮﻱ ﺗﻴﺮﻕ ﻭﺻﻨﺪ • ﻳﻠﻜﻮﻭ• ﺗﺮﻡ ﺑﺎﺳﺖ –ﺓﻟﻤﺘﺤﺪﺍﻟﻤﻤﻠﻜﺔ ﺗﻄﻮ ﺳﻲﻭﻟﻔﻴﺮﺍﺛﺔﺍﺭﻟﻮﺍﻋﻠﻢﻳﺮ ﺗﻄﻮ –ﺓﻟﻤﺘﺤﺪﺍﻟﻤﻤﻠﻜﺔ ﺑﺎﺳﺖ ﺗﺮﻡ ﻳﻠﻜﻮﻭ• ﺕﺣﺎﻟﻠﻘﺎﺍﻭ • ﻣﺆ ﻣﺎﺳﺴﺔ ﻳﻜﻞ ﻓﻮﺟﻴﻪ ﻣﺮﻷﺍﺓﻟﻤﺘﺤﺪﺍﺕﻳﺎﻻﻟﻮﺑﺎﻛﺲ ﻳﻜﻴﺔ -- ﺽﻣﺮ

ﻣﻘﺪﻣﺔ ﺍﻟﻌﻤﻴﺪ ﺍﻟﻤﺸﺎﺭﻙ ﻟﺸﺆﻭﻥ ﺍﻟﺒﺤﺚ ﺍﻟﻌﻠﻤﻲ ﻭ ﺍﻟﺪﺭﺍﺳﺎﺕ ﺍﻟﻌﻠﻴﺎ

ﻳﺸﺮﻓﻨﻲ ﺃﻥ ﺃﻗﺪﻡ ﻟﻜﻢ ﺍﻟﻄﺒﻌﺔ ﺍﻟﺴﻨﻮﻳﺔ ﺍﻟﻌﺸﺮﻳﻦ ﺍﻟﺨﺎﺻﺔ ﺑﻤﻼﻣﺢ ﺑﺤﻮﺙ ﻭﺇﺳﻬﺎﻣﺎﺕ ﻛﻠﻴﺔ ﺍﻟﻄﺐ ﻭﺍﻟﻌﻠﻮﻡ ﺍﻟﺼﺤﻴﺔ ﺑﺠﺎﻣﻌﺔ ﺍﻹﻣﺎﺭﺍﺕ ﺍﻟﻌﺮﺑﻴﺔ ﺍﻟﻤﺘﺤﺪﺓ

ﻧﺤﻦ ﻻﺯﻟﻨﺎ ﻧﺤﺎﻓﻆ ﻓﻲ ﻫﺬه ﺍﻟﺴﻨﺔ ﺍﻟﻌﺸﺮﻭﻥ ﻭﻛﻤﺎ ﻋﻬﺪﺗﻢ ﻓﻲ ﺍﻟﺴﻨﻮﺍﺕ ﺍﻟﺘﺴﻊ ﻋﺸﺮ ﺍﻟﻤﺎﺿﻴﺔ ﻋﻠﻰ ﺃﻥ ﻧﺴﺘﻤﺮ ﻓﻲ ﻧﻬﺠﻨﺎ ﻟﺘﻮﻋﻴﺔ ﺍﻟﻤﺠﺘﻤﻊ ﺑﺈﺳﻬﺎﻣﺎﺕ ﺍﻟﺒﺤﻮﺙ ﺍﻟﻌﻠﻤﻴﺔ ﻓﻲ ﺟﺎﻣﻌﺔ ﺍﻹﻣﺎﺭﺍﺕ ﺍﻟﻌﺮﺑﻴﺔ ﺍﻟﻤﺘﺤﺪﺓ ﺑﻤﺸﺎﺭﻛﺔ ﺍﻟﺒﻴﺌﺔ ﺍﻷﻛﺎﺩﻳﻤﻴﺔ ﻓﻲ ﺩﺍﺧﻞ ﺍﻟﺪﻭﻟﺔ ﻭﺧﺎﺭﺟﻬﺎ، ﻭﺫﻟﻚ ﻣﻦ ﺧﻼﻝ ﺍﻟﻌﺪﻳﺪ ﻣﻦ ﺍﻟﻤﻨﺸﻮﺭﺍﺕ ﺍﻟﺒﺤﺜﻴﺔ ﻭﺍﻟﻤﺴﺎﻫﻤﺎﺕ ﺍﻟﺪﻭﻟﻴﺔ ﻭﺍﻟﻮﻃﻨﻴﺔ ﻓﻲ ﺍﻟﻠﻘﺎﺀﺍﺕ ﺍﻟﻌﻠﻤﻴﺔ ﻭﺍﻷﻧﺸﻄﺔ ﺍﻷﻛﺎﺩﻳﻤﻴﺔ ﺍﻷﺧﺮﻯ، ﻛﻤﺎ ﻧﺤﺎﻓﻆ ﻋﻠﻰ ﻣﻮﻗﻌﻨﺎ ﺍﻟﺮﺍﺋﺪ ﻛﺄﻓﻀﻞ ﻣﺮﻛﺰ ﻟﻠﺒﺤﻮﺙ ﺍﻟﻄﺒﻴﺔ ﺍﻟﺤﻴﻮﻳﺔ ﻓﻲ ﺩﻭﻟﺔ ﺍﻹﻣﺎﺭﺍﺕ ﻭﺇﺣﺪﻯ ﺍﻋﻠﻲ ﺍﻟﻤﺮﺍﻛﺰ ﻓﻲ ﻣﻨﻄﻘﺔ ﺍﻟﺸﺮﻕ ﺍﻷﻭﺳﻂ.

ﻭﻫﺬﺍ ﺍﻟﺠﻬﺪ ﺍﻟﻤﺸﺘﺮﻙ ﻻ ﻳﻤﻜﻦ ﺗﺤﻘﻴﻘﻪ ﻭﺍﻟﺤﻔﺎﻅ ﻋﻠﻴﻪ ﺇﻻ ﻓﻲ ﺑﻴﺌﺔ ﺗﻘﺪﻣﻴﺔ ﻭﺗﻌﺎﻭﻧﻴﺔ ﺣﻴﺚ ﻳﻬﺪﻑ ﻣﻜﺘﺐ ﺍﻟﺒﺤﻮﺙ ﻭﺍﻟﺪﺭﺍﺳﺎﺕ ﺍﻟﻌﻠﻴﺎ ﺇﻟﻰ ﺗﻌﺰﻳﺰ ﻫﺬه ﺍﻟﺒﻴﺌﺔ ﺍﻟﻌﻠﻤﻴﺔ ﻋﻦ ﻃﺮﻳﻖ ﺗﺨﺼﻴﺺ ﺍﻟﻤﻮﺍﺭﺩ ﺑﺼﻮﺭﺓ ﺣﻜﻴﻤﺔ ﻭﺫﻟﻚ ﻟﺮﻋﺎﻳﺔ ﻗﻮﺓ ﺟﺪﻳﺪﺓ ﻭﺗﻮﻓﻴﺮ ﺍﻟﻤﻮﺍﺭﺩ ﻟﻠﺤﻔﺎﻅ ﻋﻠﻰ ﺍﻟﻤﻌﺪﺍﺕ ﺍﻟﻘﺪﻳﻤﺔ ﻭﺗﺮﻛﻴﺐ ﺍﻟﻤﻌﺪﺍﺕ ﺍﻟﺤﺪﻳﺜﺔ ﻟﺘﺴﻴﻴﺮ ﺫﺧﺎﺋﺮ ﺍﻟﻜﻠﻴﺔ ﻟﻼﺳﺘﻬﻼﻙ ﺍﻟﻌﺎﻡ. ﻟﻘﺪ ﺍﻟﻘﻴﻨﺎ ﺍﻟﻀﻮﺀ ﻓﻲ ﻫﺬه ﺍﻟﺬﻛﺮﻯ ﺍﻟﺴﻨﻮﻳﺔ ﻟﻠﻄﺒﻌﺔ ﺍﻟﻌﺸﺮﻭﻥ ﻋﻠﻰ ﻣﺮﺍﻓﻖ ﺍﻟﺒﺤﻮﺙ ﺍﻟﻤﺮﻛﺰﻳﺔ ﻣﺜﻞ ﻭﺣﺪﺓ ﺍﻷﺑﺤﺎﺙ ﺍﻟﺘﺤﻠﻴﻠﻴﺔ ﻭﻣﺮﻛﺰ ﻓﺴﻴﻮﻟﻮﺟﻴﺎ ﺍﻟﻜﻬﺮﺑﺎﺀ ﻭﻭﺣﺪﺓ ﺍﻟﺘﺼﻮﻳﺮ ﻭﺍﻷﺷﻌﺔ ﻭﻣﺮﻓﻖ ﺍﻟﺨﻠﻴﺔ ﺍﻟﺠﺰﺋﻴﺔ ﺍﻟﺤﻴﻮﻳﺔ، ﻛﻤﺎ ﻗﻤﻨﺎ ﺑﺘﺨﺼﻴﺺ ﺟﺰﺀ ﻣﻦ ﺍﻟﻤﺠﻠﺪ ﻷﻫﻢ ﺍﻧﺠﺎﺯﺍﺕ ﻭﻣﺸﺎﺭﻛﺎﺕ ﺍﻟﻤﻜﺘﺒﺔ ﺍﻟﻮﻃﻨﻴﺔ ﺍﻟﻄﺒﻴﺔ.

ﻧﻮﺩ ﺃﻥ ﻧﻌﺒﺮ ﻋﻦ ﺍﻣﺘﻨﺎﻧﻨﺎ ﻟﻺﺳﻬﺎﻣﺎﺕ ﻭﺍﻟﺪﻋﻢ ﺍﻟﻤﺘﻮﺍﺻﻞ ﻟﺠﺎﻣﻌﺔ ﺍﻹﻣﺎﺭﺍﺕ ﺍﻟﻌﺮﺑﻴﺔ ﺍﻟﻤﺘﺤﺪﺓ ﻭﺍﻟﺘﻲ ﺗﻌﺘﺒﺮ ﺳﺒﺎﻗﻪ ﻓﻲ ﺗﻨﻔﻴﺬ ﺍﻟﺒﺤﻮﺙ ﻭﻫﺬﺍ ﻳﻌﻜﺲ ﺭﺅﻳﺔ ﻣﻌﺎﻟﻲ ﺍﻟﺸﻴﺦ ﻧﻬﻴﺎﻥ ﻣﺒﺎﺭﻙ ﺁﻝ ﻧﻬﻴﺎﻥ ﺍﻟﺬﻱ ﺻﺮﺡ ﻣﺮﺍﺭﺍ ﻭﺗﻜﺮﺍﺭﺍ ﻋﻦ ﺍﻷﻭﻟﻴﺔ ﺍﻟﻘﺼﻮﻯ ﻟﻠﺒﺤﺚ ﺍﻟﻌﻠﻤﻲ ﺑﺠﺎﻣﻌﺔ ﺍﻹﻣﺎﺭﺍﺕ ﺍﻟﻌﺮﺑﻴﺔ ﺍﻟﻤﺘﺤﺪﺓ.

ﻭﻳﺸﺮﻓﻨﻲ ﻓﻲ ﺍﻟﺬﻛﺮﻯ ﺍﻟﺴﻨﻮﻳﺔ ﻟﻠﻄﺒﻌﺔ ﺍﻟﻌﺸﺮﻭﻥ ﺃﻥ ﺃﻋﺮﺏ ﻋﻦ ﺷﻜﺮﻱ ﻟﺠﻤﻴﻊ ﺯﻣﻼﺋﻲ ﺍﻟﺬﻳﻦ ﻛﺎﻧﻮﺍ ﻓﻲ ﻫﺬﺍ ﺍﻟﻤﻨﺼﺐ ﻭﺍﻟﺬﻳﻦ ﺑﺪﺀﻭﺍ ﻫﺬﺍ ﺍﻟﻤﺸﺮﻭﻉ ﺍﻟﻄﻤﻮﺡ ﻣﻨﺬ ﺳﻨﻮﺍﺕ ﻋﺪﺓ:

ﺃ.ﺩ ﻭﻳﻢ ﻻﻣﺮﺯ (١٩٩٠ )١٩٩٤- ﺃ.ﺩ ﺍﻧﺪﺭﻳﻮ ﺟﺎﺭﻧﺮ (١٩٩٥ )١٩٩٧- ﺩ.ﺳﻬﺎﻡ ﺍﻟﺪﻳﻦ ﻛﻠﺪﺍﺭﻱ (١٩٩٨ )٢٠٠٠- ﺃ.ﺩ ﻣﻴﻮﺩﺭﺍﺝ ﻟﻮﻛﻴﺘﺞ (٢٠٠١ )٢٠٠٧- )٢٠٠٧-

ﺍﻷﺳﺘﺎﺫ ﺍﻟﺪﻛﺘﻮﺭ/ ﺳﻬﺎﻡ ﺍﻟﺪﻳﻦ ﻛﻠﺪﺍﺭﻱ ﻣﺴﺎﻋﺪ ﺍﻟﻌﻤﻴﺪ ﻟﻠﺒﺤﻮﺙ ﻭﺍﻟﺪﺭﺍﺳﺎﺕ ﺍﻟﻌﻠﻴﺎ (٢٠٠٨ )٢٠١١-

ﻛﻨﺴﻮﺭﺑﺎ ﻥ ﻛﻨﺴﻮﺭﺑﺎ ﻳﻄﺎﻟﺒﺮﺍﻓﻲﻟﺜﻘﺎﺍﻟﻤﺠﻠﺲﺍ• ﻧﻲ ﺓﻟﻤﺘﺤﺪﺍﺑﻴﺔﻟﻌﺮﺍﺕﺍﺭﻣﺎﻹﺍﻟﺔﻭﺩﻓﻲ ﻧﻲ ﻳﻄﺎﻟﺒﺮﺍﻓﻲﻟﺜﻘﺎﺍﻟﻤﺠﻠﺲﺍ• • ﻟﻴﺴﻜﻮﺃ -- ﻟﻌﺼﺒﻴﺔﺍﻡﻟﻌﻠﻮﺍ • ﻭﻟﺪﺍﺩﺭﻓﺎﺭﻫﺎ ﻟﻴﺔ -- ﻥﻃﺎﻟﺴﺮﺍﻓﺤﺔﻟﻤﻜﺎ • ﺑﻲﺩﺩﻓﺮﺭﻫﺎ -- ﺛﺔﺍﺭﻟﻮﺍﻋﻠﻢ • ﺑﺤﺎﺃﻕﻭﺻﻨﺪ ﺷﺮﺍﺛﺮﺙ -- ﺕﻣﻴﻨﺎﻟﻔﻴﺘﺎﺍﻧﻘﺺ • ﺗﻴﺠﻦﺳﺎ -- ﻱﻟﺴﻜﺮﺍﺽﻣﺮ • ﻳﺖﻧﻴﺴﺎﺳﻮ -- ﺕﺑﺎﺻﺎﻹﺍ ﺣﻤﺮﻷﺍﻝﻟﻬﻼﺍ• -- ﺕﺑﺎﺻﺎﻹﺍ • ﺑﻮﺃﻫﻴﺌﺔ ﻇﺒﻲ ﻟﻠﺒﻴﺌﺔ -- ﻟﺒﻴﺌﻴﺔﺍﻟﺼﺤﺔﺍ • ﺟﺎ ﺭﻧﻮﻣﻌﺔ ﻟﻴﻨﺎﻭﺭﻛﺎﺙ -- ﻟﺒﻴﺌﻴﺔﺍﻟﺼﺤﺔﺍ • ﺟﺎ ﻧﻴﺎﺭﻟﻴﻔﻮﻛﺎﻣﻌﺔ -- ﺛﺔﺍﺭﻟﻮﺍﻋﻠﻢ • ﻃﻔﺎﻷﺍﻣﺴﺘﺸﻔﻰ ﻝ ﺳﻄﻦﺑﻮﻓﻲ -- ﺛﺔﺍﺭﻟﻮﺍﻋﻠﻢ • ﺍﻫﻴﺌﺔ ﻇﺒﻲﺑﻮﺑﺄﻟﺼﺤﺔ -- ﻟﻤﻬﻨﻴﺔﺍﻟﺼﺤﺔﺍ • ﺑﻮﺃﻫﻴﺌﺔ ﻏﺬﻟﻸﻇﺒﻲ ﻳﺔ -- ﺍ ﺍﺩﻭﻟﺘﻤﺮ ﻱﻟﺴﻜﺮﺍﻭﺀ ﺍﺩﻭﻟﺘﻤﺮ ﺍ ﻭﻟﺪﺍﻛﺰﻟﻤﺮﺍ• ﺍﺭﻟﻮﺍﺳﺔﻟﻠﻬﻨﺪﻟﻲ ﻳﺔﻟﺤﻴﻮﺍﻟﺘﻘﻨﻴﺔﺍﻭﺛﻴﺔ -- ﺍﺭﻟﻮﺍﻋﻠﻢ ﻥﻃﺎﻟﺴﺮﺍﻭﺛﺔ ﺍﺭﻟﻮﺍﻋﻠ ﻢ

ﻭ ﺗﻌﻠﻤﻮﻛﻤﺎ ﻓﺈﻥ ﺟﺎﻥ ﻟﻤﺘﺤﺪﺍﺑﻴﺔﻟﻌﺮﺍﺕﺍﺭﻣﺎﻹﺍﻣﻌﺔ ﺃﻟﻲﺗﻮﺓ ﻯﻛﺒﺮﻫﻤﻴـﺔ ﺃﻟﻲﺗﻮﺓ ﻟﻤﺘﺤﺪﺍﺑﻴﺔﻟﻌﺮﺍﺕﺍﺭﻣﺎﻹﺍﻣﻌﺔ ﺟﺎﻥ ﻓﺈﻥ ﺗﻌﻠﻤﻮﻛﻤﺎ ﻭ ﻟﻠﺒﺤﻮ ﺍﺙ ﻭﻟﻌﻠﻤﻴﺔ ﻟﻌﺎﺍﺓﺩﻟﺠﻮﺍﻳﻴﺮﻣﻌﺎﻓﻖ ﻭﻟﻤﻴﺔ ﻧﺤﻦ ﺍﻛﻠﻴﺔﻓﻲ ﻡﻟﻌﻠﻮﺍﻭﻟﻄﺐ ﺍﻛﻠﻴﺔﻓﻲ ﻧﺤﻦ ﻭﻟﻤﻴﺔ ﻟﻌﺎﺍﺓﺩﻟﺠﻮﺍﻳﻴﺮﻣﻌﺎﻓﻖ ﻭﻟﻌﻠﻤﻴﺔ ﺍﺙ ﻟﻠﺒﺤﻮ ﺍ ﻭﺭﻓﺨﻮﻟﺼﺤﻴـﺔ ﺭﺑﻘﺪﻥ ﺗﻨﺎ ﺍﻣﻮﻋﻠﻰ ﻟﺘﺤﺪﺍﺍﻫﺬﻛﺒﺔ ﻭﻱ ﻣﻴﻦﻣﻠﺘﺰﺳﻨﺒﻘﻰ ﺑﺘﺤﻘﻴﻖ ﻣﻴﻦﻣﻠﺘﺰﺳﻨﺒﻘﻰ ﻭﻱ ﻟﺘﺤﺪﺍﺍﻫﺬﻛﺒﺔ ﺍﻣﻮﻋﻠﻰ ﺗﻨﺎ ﺭﺑﻘﺪﻥ ﻭﺭﻓﺨﻮﻟﺼﺤﻴـﺔ ﺍ ﻳﺎﻟﻮﻭﺃ ﻭﺗﻨﺎ ﺍﻓﻲًﺍﺟﻬﺪﺍﻟﻮﻧﺄﻟﻦ ًﻣﺎﻗﺪﻟﻤﻀﻲ ﺗﻄﻮﻓﻲ ﺍﺭﻗﺪﻳﺮ ﻟﺒﺤﺜﻴـﺔﺍﺗﻨﺎﻧﺎﻣﻜﺎﺇﻭﺗﻨﺎ ﺍﺭﻗﺪﻳﺮ ﺗﻄﻮﻓﻲ ًﻣﺎﻗﺪﻟﻤﻀﻲ ﺍﻓﻲًﺍﺟﻬﺪﺍﻟﻮﻧﺄﻟﻦ ﻭﺗﻨﺎ ﻳﺎﻟﻮﻭﺃ ﺗﻘﺎﺭﻻﺍﻭ ﺀ ﺑﻬﺎ ﺗﻌﺰﻭ ﺍﻟﺒﺤﺚﺍﻉﻗﻄﺎﻳﺰ ﺭﻭﻟﻌﻠﻤﻲ .ﺗﻪﺟﺎﻣﺨﺮﻭهﺍﻣﺴﺘﻮﻓﻊ ﺭﻭﻟﻌﻠﻤﻲ ﺍﻟﺒﺤﺚﺍﻉﻗﻄﺎﻳﺰ ﺗﻌﺰﻭ ﺑﻬﺎ ﺀ ﺗﻘﺎﺭﻻﺍﻭ ﻭ ﻻ ﺳﻮﻳﺴﻌﻨﻲ ﺍﻯ ﻟﺸﺪﺍﺑﻲﻋﺠﺎﺇﻋﻦﻟﺘﻌﺒﻴﺮ ﻟﻤﺤﺎﺑﺎﻳﺪ ﻓﻈـﺔ ﺩﺟﻮﻋﻠﻰ ﺋﺞﻧﺘﺎﺓ ﺩﺟﻮﻋﻠﻰ ﻓﻈـﺔ ﻟﻤﺤﺎﺑﺎﻳﺪ ﻟﺸﺪﺍﺑﻲﻋﺠﺎﺇﻋﻦﻟﺘﻌﺒﻴﺮ ﺍﻯ ﺳﻮﻳﺴﻌﻨﻲ ﻻ ﻭ ﺍﻟﻌﻠﻤﻴـﺔﺍﺙﻟﺒﺤﻮﺍ ﻳﺠﺮﻟﺘﻲ ﻧﻮﻟﻤﺘﻔﺎﺍﻧﺎﺣﺜﻮﺑﺎﻳﻬﺎ ﻟﺮﺑﺎﻥ ﻏﻢ ﻣﺔﺯﻷﺍﻑﻭﻇﺮﻣﻦ ﻏﻢ ﻟﺮﺑﺎﻥ ﻧﻮﻟﻤﺘﻔﺎﺍﻧﺎﺣﺜﻮﺑﺎﻳﻬﺎ ﻳﺠﺮﻟﺘﻲ ﺍﻟﻌﻠﻤﻴـﺔﺍﺙﻟﺒﺤﻮﺍ .ﻟﻤﻴﺔﻟﻌﺎﺍﻟﻴﺔﻟﻤﺎﺍ ﺗﻬﺎ ﻧﻴﻨﺎ ﻟﻜﻢ ﻋﺮﺃﻭﺟﻤﻴﻌﺎ ﺏ ﻳﺮﺗﻘﺪﻭﻱﺷﻜﺮﻋﻦ ﺗﻜﻢﺍﺯﻧﺠﺎﻻﻱ ﻳﺮﺗﻘﺪﻭﻱﺷﻜﺮﻋﻦ ﺏ ﻋﺮﺃﻭﺟﻤﻴﻌﺎ ﻟﻜﻢ ﻧﻴﻨﺎ ﺗﻬﺎ .ﻟﻤﻴﺔﻟﻌﺎﺍﻟﻴﺔﻟﻤﺎﺍ .ﺻﻠﺔﺍﻟﻤﺘﻮﺍ

ﺍﻷﺳﺘ ﺪﻛﺍﻟﺎﺫ ﺘﻮﺭ/ ﻳﺪﻤﺤﻣ ﻮﺳ ﻳﻲﻨﺑﻦﺴﺣﻒ ﺎﺱ ﻧﺎ ﻣﺪﺋﺐ ﺭﻟﻤﺸﺎﺍﻣﻌﺔﻟﺠﺎﺍﻳﺮ ﺍﻡﻟﻠﻌﻠﻮﻙ ﻭﻟﻄﺒﻴﺔ ﺍﻛﻠﻴﺔﻋﻤﻴﺪ ﻟﺼﺤﻴﺔﺍﻡﻟﻌﻠﻮﺍﻭﻟﻄﺐ ﺍﻛﻠﻴﺔﻋﻤﻴﺪ ﻭﻟﻄﺒﻴﺔ ﺍﻡﻟﻠﻌﻠﻮﻙ ﺭﻟﻤﺸﺎﺍﻣﻌﺔﻟﺠﺎﺍﻳﺮ ﻣﺪﺋﺐ ﻧﺎ ﻣﻘﺪﻣﺔ ﺍﻟﻌﻤﻴﺪ ﺍﻟﻤﺸﺎﺭﻙ ﻟﺸﺆﻭﻥ ﺍﻟﺒﺤﺚ ﺍﻟﻌﻠﻤﻲ ﻭ ﺍﻟﺪﺭﺍﺳﺎﺕ ﺍﻟﻌﻠﻴﺎ

ﻳﻌﺘﺒﺮ ﻫﺬﺍ ﺍﻟﺘﻌﺮﻳﻒ ﺍﻟﺒﺤﺜﻲ ﺩﻻﻟﺔ ﻋﻠﻰ ﺍﻟﻤﺴﺎﻫﻤﺎﺕ ﻭﺍﻟﻤﺴﺎﻋﻲ ﺍﻷﻛﺎﺩﻳﻤﻴﺔ ﻷﻋﻀﺎﺀ ﻫﻴﺌﺔ ﺍﻟﺘﺪﺭﻳﺲ ﻭﻣﻮﻇﻔﻲ ﻛﻠﻴﺔ ﺍﻟﻄﺐ ﻭﺍﻟﻌﻠﻮﻡ ﺍﻟﺼﺤﻴﺔ.

ﻭﺇﻧﻨﺎ ﻧﺘﺒﻊ ﻣﻨﺬ ﻋﺎﻣﺎ19 ً ًﺗﻘﻠﻴﺪﺍ ﻟﺘﻮﻋﻴﺔ ﺍﻟﻤﺠﺘﻤﻊ ﺧﺎﺭﺝ ﺃﺳﻮﺍﺭ ﺍﻟﺠﺎﻣﻌﺔ ﺑﺎﻹﺳﻬﺎﻣﺎﺕ ﺍﻟﺘﻲ ﺗﻘﺪﻣﻬﺎ ﻛﻠﻴﺔ ﺍﻟﻄﺐ ﻭﺍﻟﻌﻠﻮﻡ ﺍﻟﺼﺤﻴﺔ ﻟﻠﻤﻌﺮﻓﺔ ﻭﻟﻸﻣﺔ، ﻓﻤﻦ ﺧﻼﻝ ﺇﻧﺘﺎﺟﻨﺎ ﺍﻟﺒﺤﺜﻲ، ﻭﺍﻟﻌﺮﻭﺽ ﺍﻟﺘﻲ ﻧﻘﺪﻣﻬﺎ ﻓﻲ ﺍﻟﻤﺆﺗﻤﺮﺍﺕ ﺍﻟﺪﻭﻟﻴﺔ ﻭﺍﻷﻧﺸﻄﺔ ﺍﻷﻛﺎﺩﻳﻤﻴﺔ ﺍﻷﺧﺮﻯ ﻓﺈﻧﻨﺎ ﻧﺴﻬﻢ ﻓﻲ ﺇﺛﺮﺍﺀ ﺍﻷﻣﺔ، ﻭﻣﺎ ﻫﺬه ﺍﻟﻄﺒﻌﺔ ﺇﻻ ﻋﺮﺽ ﻟﻨﺎ ﻭﻹﻧﺠﺎﺯﺍﺗﻨﺎ ﻓﻲ ﻧﻮﺭ ﺳﺎﻃﻊ.

ﺃﻥ ﻫﺬﺍ ﺍﻟﻤﺴﺘﻮﻯ ﻣﻦ ﺍﻹﻧﺘﺎﺟﻴﺔ ﻻ ﻳﻤﻜﻦ ﺃﻥ ﻳﺘﺤﻘﻖ ﺇﻻ ﻓﻲ ﺑﻴﺌﺔ ﺗﻘﺪﻣﻴﺔ ﻭﺗﻌﺎﻭﻧﻴﺔ، ﻭﻧﺤﻦ ـ ﻓﻲ ﻣﻜﺘﺐ ﺍﻟﺒﺤﻮﺙ ﻭﺍﻟﺪﺭﺍﺳﺎﺕ ﺍﻟﻌﻠﻴﺎ ـ ﻧﺴﻌﻰ ﺟﺎﻫﺪﻳﻦ ﻟﺘﻮﻓﻴﺮ ﺗﻠﻚ ﺍﻟﺒﻴﺌﺔ، ﻭﻳﺘﺤﻘﻖ ﺫﻟﻚ ﻣﻦ ﺧﻼﻝ ﺗﺨﺼﻴﺺ ﺍﻟﻤﻮﺍﺭﺩ ﺑﺼﻮﺭﺓ ﺣﻜﻴﻤﺔ، ﻭﺗﻮﻓﻴﺮ ﻭﺩﻋﻢ ﻣﺮﺍﻓﻖ ﺍﻟﺒﺤﺚ ﺍﻟﻌﻠﻤﻲ، ﻭﺗﺸﻤﻞ ﻫﺬه ﺍﻟﺠﻬﻮﺩ ﺗﻘﺪﻳﻢ ﺩﻋﻢ ﻟﻠﺒﺤﻮﺙ ﻣﺜﻞ ﻭﺣﺪﺓ ﺍﻟﺘﺼﻮﻳﺮ، ﻭﺍﻟﻤﺨﺘﺒﺮ ﺍﻟﺘﺤﻠﻴﻠﻲ، ﻭﻣﺮﻓﻖ ﺣﺠﺰ ﺍﻟﺤﻴﻮﺍﻧﺎﺕ، ﻭﺍﻟﻤﺨﺰﻥ ﺍﻟﻤﺮﻛﺰﻱ ﻟﻠﺒﺤﻮﺙ، ﻭﻣﻮﺭﺩ ﺍﻟﻤﻌﺪﺍﺕ ﺍﻷﺳﺎﺳﻴﺔ، ﺑﺎﻹﺿﺎﻓﺔ ﺇﻟﻰ ﺫﻟﻚ ﻓﺈﻧﻨﺎ ـ ﺑﺎﺗﺒﺎﻉ ﺃﺳﻠﻮﺏ ﺍﻟﺸﻔﺎﻓﻴﺔ ـ ﺭﺣﺒﻨﺎ ﺑﺎﻟﻨﻘﺪ ﺍﻟﺒﻨﺎﺀ ﻭﺑﺮﺩﻭﺩ ﺃﻓﻌﺎﻝ ﻭﺁﺭﺍﺀ ﺃﻋﻀﺎﺀ ﻫﻴﺌﺔ ﺍﻟﺘﺪﺭﻳﺲ ﺍﻟﺘﻲ ﻧﺮﻯ ﺃﻧﻬﺎ ﺗﻮﻓﺮ ـ ﻋﻠﻰ ﺍﻟﻤﺪﻯ ﺍﻟﻄﻮﻳﻞ ـ ﺍﻟﺒﻴﺌﺔ ﺍﻟﻤﻨﺎﺳﺒﺔ ”ﻟﻠﻤﺴﺎﺀﻟﺔ“ ﻭﺍﻟﺘﻲ ﺗﺮﻛﺰ ﻋﻠﻰ ﺗﻌﺰﻳﺰ ﺇﻧﺘﺎﺟﻴﺔ ﺍﻟﺒﺤﻮﺙ.

ﻟﻘﺪ ﺑﺪﺃ ﺍﻟﺪﻛﺘﻮﺭ ﺭﻭﺭﻱ ﻫﻴﻮﻡ ـ ﻧﺎﺋﺐ ﻣﺪﻳﺮ ﺍﻟﺠﺎﻣﻌﺔ ـ ﻓﻲ ﺍﻟﺴﻨﺔ ﺍﻟﻤﺎﺿﻴﺔ ﺍﻟﺘﻨﻔﻴﺬ ﺍﻟﻔﻌﻠﻲ ﻟﺮﺅﻳﺔ ﻣﻌﺎﻟﻲ ﺍﻟﺮﺋﻴﺲ ﺍﻷﻋﻠﻰ ﻟﻠﺠﺎﻣﻌﺔ ـ ﺍﻟﺸﻴﺦ ﻧﻬﻴﺎﻥ ﻣﺒﺎﺭﻙ ﺁﻝ ﻧﻬﻴﺎﻥ ـ ﻭﺍﻟﺘﻲ ﺣﺪﺩﺕ ﺟﺎﻣﻌﺔ ﺍﻹﻣﺎﺭﺍﺕ ﻋﻠﻰ ﺃﻧﻬﺎ ﺍﻟﺠﺎﻣﻌﺔ ﺍﻟﺮﺍﺋﺪﺓ ﻓﻲ ﺩﻭﻟﺔ ﺍﻹﻣﺎﺭﺍﺕ ﺣﻴﺚ ﺗﻜﻮﻥ ﺍﻷﻭﻟﻮﻳﺔ ﻹﻧﺘﺎﺝ ﻧﻮﻋﻴﺔ ﻋﺎﻟﻴﺔ ﻣﻦ ﺍﻟﺒﺤﺚ ﺍﻟﻌﻠﻤﻲ، ﻭﻗﺪ ﻭﻓﺮ ﺍﻟﺪﻋﻢ ﺍﻟﻤﺴﺘﻤﺮ ﻟﻤﻜﺎﺏ ﺷﺆﻭﻥ ﺍﻷﺑﺤﺎﺙ ﺑﺠﺎﻣﻌﺔ ﺍﻹﻣﺎﺭﺍﺕ ـ ﺑﺮﺋﺎﺳﺔ ﺍﻟﺪﻛﺘﻮﺭﺓ ﻣﻴﺜﺎﺀ ﺍﻟﺸﺎﻣﺴﻲ ـ ًﻣﺼﺪﺭﺍ ﻻ ﻳﻘﺪﺭ ﺑﺜﻤﻦ ﻟﺠﻬﻮﺩ ﻛﻠﻴﺔ ﺍﻟﻄﺐ ﻭﺍﻟﻌﻠﻮﻡ ﺍﻟﺼﺤﻴﺔ ﺍﻟﺮﺍﻣﻴﺔ ﺇﻟﻰ ﺗﻤﻜﻴﻦ ﺭﺅﻳﺔ ﺍﻟﺮﺋﻴﺲ ﺍﻷﻋﻠﻰ ﻣﻦ ﺃﻥ ﺗﺆﺗﻲ ﺛﻤﺎﺭﻫﺎ.

ﻭﻛﻤﺎ ﻫﻮ ﺍﻟﺤﺎﻝ ًﺩﺍﺋﻤﺎ، ﻓﺈﻧﻨﺎ ﻣﺪﻳﻨﻮﻥ ﻟﻠﺮﻋﺎﺓ ﺍﻟﺬﻳﻦ ﻳﻤﻜﻨﻮﻧﻨﺎ ﻣﻦ ﺍﻻﺳﺘﻤﺮﺍﺭ ﻓﻲ ﺟﻬﻮﺩﻧﺎ ﺍﻟﺒﺤﺜﻴﺔ، ﻓﺒﺪﻭﻧﻬﻢ ﻟﻢ ﻳﻜﻦ ﺑﻤﻘﺪﻭﺭ ﺑﺎﺣﺜﻴﻨﺎ ﻣﻮﺍﺻﻠﺔ ﻣﺴﺘﻮﺍﻫﻢ ﺍﻹﻧﺘﺎﺟﻲ ﺍﻟﻔﺬ ﻭﻻ ﺗﻘﺪﻳﻢ ﻣﺜﻞ ﺗﻠﻚ ﺍﻟﻌﺮﻭﺽ ﺍﻟﻔﻌﺎﻟﺔ ﻓﻲ ﺍﻟﻤﺆﺗﻤﺮﺍﺕ ﺍﻟﺒﺤﺜﻴﺔ ﺍﻟﺮﺋﻴﺴﻴﺔ ﺍﻟﺘﻲ ﺗﻌﻘﺪ ًﺩﻭﻟﻴﺎ ًﻭﻣﺤﻠﻴﺎ. ﺍﻟﻤﺤﺘﻮﻳﺎﺕ

ﻛﻠﻤﺔ ﺍﻟﻌﻤﻴﺪ ﻣﻘﺪﻣﺔ ﺍﻟﻌﻤﻴﺪ ﺍﻟﻤﺸﺎﺭﻙ ﻟﺸﺆﻭﻥ ﺍﻟﺒﺤﺚ ﺍﻟﻌﻠﻤﻲ ﻭ ﺍﻟﺪﺭﺍﺳﺎﺕ ﺍﻟﻌﻠﻴﺎ ﺗﻤﻬﻴﺪ ﻣﻌﻬﺪ ﺟﺎﻣﻌﺔ ﺍﻹﻣﺎﺭﺍﺕ ﻟﻠﺼﺤﺔ ﺍﻟﻌﺎﻟﻤﻴﺔ

114 ﺑﺤﻮﺙ ﻋﻠﻢ ﺍﻟﻤﻨﺎﻋﺔ ﻭ ﺍﻟﺘﻨﻈﻴﻢ ﺍﻟﻤﻨﺎﻋﻲ 1 ﺍﻟﻤﻨﺸﻮﺭﺍﺕ ﺍﻟﻌﻠﻤﻴﺔ ﻟﻸﻗﺴﺎﻡ 116 ﺑﺤﻮﺙ ﺍﻟﺘﻌﻠﻴﻢ ﺍﻟﻄﺒﻲ 3 ﺍﻟﺘﺸﺮﻳﺢ 118 ﺑﺤﻮﺙ ﺍﻟﻌﻠﻮﻡ ﺍﻟﻌﺼﺒﻴﺔ 8 ﺍﻟﻜﻴﻤﻴﺎﺀ ﺍﻟﺤﻴﻮﻳﺔ 121 ﺑﺤﻮﺙ ﻋﻠﻢ ﺍﻷﻭﺭﺍﻡ 18 ﻃﺐ ﺍﻟﻤﺠﺘﻤﻊ 123 ﺑﺤﻮﺙ ﺍﻷﺻﺎﺑﺎﺕ 26 ﻃﺐ ﺍﻟﻌﺎﺋﻠﺔ 32 ﺍﻟﻄﺐ ﺍﻟﺒﺎﻃﻨﻲ 127 ﺑﺤﻮﺙ ﺍﻟﻄﻠﺒﺔ 38 ﺍﻟﺘﻌﻠﻴﻢ ﺍﻟﻄﺒﻲ 41 ﺍﻷﺣﻴﺎﺀ ﺍﻟﺪﻗﻴﻘﺔ ﻭ ﺍﻟﻨﺎﻋﺔ 133 ﺩﻋﻢ ﺍﻷﺑﺤﺎﺙ 50 ﺃﻣﺮﺍﺽ ﺍﻟﻨﺴﺎﺀ ﻭ ﺍﻟﺘﻮﻟﻴﺪ 134 ﻭﺣﺪﺓ ﺍﻷﺑﺤﺎﺙ ﺍﻟﺘﺤﻠﻴﻠﻴﺔ 53 ﻃﺐ ﺍﻷﻃﻔﺎﻝ 136 ﻣﺮﻛﺰ ﻓﺴﻴﻮﻟﻮﺟﻴﺎ ﺍﻟﻜﻬﺮﺑﺎﺀ 64 ﻋﻠﻢ ﺍﻷﻣﺮﺍﺽ 137 ﻭﺣﺪﺓ ﺍﻟﺘﺼﻮﻳﺮ ﺑﺎﻷﺷﻌﺔ 71 ﻋﻠﻢ ﺍﻷﺩﻭﻳﺔ 138 ﻣﺮﻓﻖ ﺍﻟﺨﻠﻴﺔ ﺍﻟﺠﺰﻳﺌﻴﺔ ﺍﻟﺤﻴﻮﻳﺔ 78 ﻋﻠﻢ ﻭﻇﺎﺋﻒ ﺍﻷﻋﻀﺎﺀ 139 ﺍﻟﻤﻜﺘﺒﺔ ﺍﻟﻄﺒﻴﺔ ﺍﻟﻮﻃﻨﻴﺔ 87 ﺍﻟﻄﺐ ﺍﻟﻨﻔﺴﻲ 92 ﻋﻠﻢ ﺍﻷﺷﻌﺔ 141 ﻋﻮﺍﻣﻞ ﺍﻟﺘﺄﺛﻴﺮ 95 ﺍﻟﺠﺮﺍﺣﺔ

105 ﻓﺮﻕ ﺃﻭﻟﻮﻳﺎﺕ ﺍﻟﺒﺤﻮﺙ ﺍﻟﻌﻠﻤﻴﺔ 107 ﺑﺤﻮﺙ ﺍﻟﺴﻜﺮﻱ ﻭ ﺃﻣﺮﺍﺽ ﺍﻟﻘﻠﺐ ﻭ ﺍﻷﻭﻋﻴﺔ ﺍﻟﺪﻣﻮﻳﺔ 110 ﺑﺤﻮﺙ ﻋﻠﻢ ﺍﻟﻮﺭﺍﺛﺔ ﻭ ﺍﻟﺘﻄﻮﻳﺮ

هيئة التحرير PRODUCTION CREDITS المحرر: Editor: األستاذ ويم المرز Prof Wim Lammers السكرتير اإلداري: Secretarial Management: السيد راجاغوباالن Mr P Rajagopalan التصميم: Graphic Design: السيدة إفانا ليزاريتوري Ms Ivanna Lizarriturri التخطيط والتنسيق: :Layout and Formatting السيدة ادريانا كازكي Ms Adriana Khazki التصوير: Photography: السيد أشوك براساد Mr Ashok Prasad الترجمة: Arabic Translation: اآلنسة العنود الجابري Ms Al-Anood Al-Jaberi

Inside research images provided by the individual researchers

الصور المدرجة بالداخل من قبل الباحثين

المنشورات السنوية لمكتب العميد المشارك Annual Publication of the Office of The Assistant Dean لشؤون البحث العلمي و الدراسات العليا for Research & Graduate Studies

طبع بواسطة وحدة المطبوعات Printed by Publication Department, جامعة االمارات العربية المتحدة UAE University 2010 2010 Research Publications & Research of Medicine 2010 - Faculty and Health Sciencies Profiles

YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20 YEARS OF MEDICAL RESEARCH AT FMHS I 20