2008 Research Publications & Research Profiles

United Arab Emirates University Faculty of Medicine and Health Sciences Office of the Associate Dean for Research & Graduate Studies PRODUCTION CREDITS

Editor: Prof. Wim Lammers Secretarial Management: Mr. P Rajagopalan Graphic Design: Ms. Ivanna Lizarriturri Graphic Assistant: Ms. Shaikha Al Mazrouei Photography: Mr. Ashok Prasad Arabic Translation: Mr. Mohammed Zaggar

Inside research images provided by the researchers

Cover neurons image by ©iStockphoto.com/ktsimage building by Ashok Prasad

Annual Publication of the Office of The Associate Dean for Research & Graduate Studies

Printed by Publication Department, UAE University Table of Contents

Preface I Dean’s message II

Research Publications by Department 0 Anatomy 1 Biochemistry 7 Community Medicine 16 Family Medicine 26 Internal Medicine 28 Medical Education 35 Medical Microbiology & Immunology 38 Obstetrics & Gynaecology 46 Pediatrics 48 Pathology 54 Pharmacology 62 Physiology 69 Psychiatry 79 Radiology 84 Surgery 87

Research Priority Groups 99 Diabetes and Cardiovascular 101 Genetics and Development 104 Immunology and Immunoregulation 109 MERGE 112 Neurosciences 114 Oncology 116 Trauma 118

Medical Student Research 123

National Medical Library and Impact Factors 129 Preface

This is the 18th yearly report on Research Publications and Research Profiles for the Faculty of Medicine & Health Sciences, United Arab Emirates University. This volume is a continuation of a series of annual reports, dating back to our very first report in 1991.

As usual, every year, we try to upgrade and maintain the quality of this directory and this year is no exception. We have continued to include the Departmental Profiles and the Reports from the Research Priority Groups, including a report on Student Medical Research.

The main change this year is the re-design of the booklet’s layout. The new layout carries a more uniform style with a consistent use of visual elements; it also uses a modern typographical selection and a more functional way to display information. With the new layout you should find it easier to identify chapters, sections and text categories. Furthermore, the list of impact factors, at the back of the booklet, has been changed from a strict alphabetical listing to one that lists the journals in which we have succeeded in publishing this year by their impact factors; there is no reason to hide our achievements!

As always, it is a pleasure to thank the indivuduals who have put this report together to transform it into one book. Ms Ivanna Lizarriturri was the Graphic Designer assisted by Ms Shaikha Butti. Mr Rajagopalan, as always, took care of editing the initial departmental contribution and the communication between all parties while Mrs Pamela Roberts reviewed the booklet for mistakes and conspicuous inconsistencies. Mr Ashook provided numerous photographs and Mr Mohamed Zaggar took care of the translation.

Dr Wim Lammers, Dr Sehamuddin Galadari, Editor Associate Dean for Research & Graduate Studies

Dean’s Message It is my pleasure in my final report as Dean to offer sincere thanks to faculty, students and technical staff for another very high level of research productivity during the calendar year 2008. Professor Wim Lammers is to be congratulated yet again for editing the diverse information into a cohesive document. Thanks also to Ms. Ivanna Lizarriturri for the improved style.

Grant sponsorship at FMHS involves a wide range of benefactors such as Sheikh Hamdan Awards for Medical Science, Terry Fox Cancer Funds in Dubai and Abu Dhabi and the Michael J Fox Foundation. The British Council in the UAE continues to enable student research electives to the United Kingdom in partnership with FMHS. Our dedicated students and their research mentors, both faculty and staff, should be suitably proud of their continued high level of achievement during 2008. Their efforts certainly paid off in the 6th GCC Medical Students Conference in Al Ain.

Major research conferences celebrate the efforts of our Research Priority Groups. Many international researchers attend these meetings as regular delegates to enjoy the well earned scientific reputations of the meetings. It is also a joy to see greater participation in the programs of UAEU graduate students, residents, research fellows and clinical colleagues from local hospitals whose contributions to oral presentations and posters match international standards.

A highlight of 2008 was the announcement of a Centre of Excellence funded by the National Research Foundation for a Genes and Disease collaboration from FMHS and Zayed University led by Professor Lihadh Al-Gazali and Dr. Bassam Ali.

The UAE University Research Affairs sector led by Her Excellency Dr. Maitha Al Shamsi, ably assisted by Professor Mohamed Fahim, and the FMHS research administration team led by Dr. Sehamuddin Galadari are warmly appreciated by all FMHS researchers.

It is the challenge of all good biomedical research to enhance the quality of patient care through improved diagnosis or better treatment. With growing support from Tawam Hospital - Johns Hopkins Medicine and Al Ain Hospital - Medical University of Vienna VAMED, there is clear evidence of positive steps in enhancing clinical research. Thank you!

S George Carruthers MD Dean

Research Publications by Department

Department of Anatomy

Research Profile

Academic staff in the Department of Anatomy Professor & Chair: pursue research interests in a number of Prof G Buzzell Professor: directions. We show considerable strength in the Prof E Adeghate fields of neurobiology, stem cells, cancer, diabetes, Prof S Karam and structure/function relations. Prof DE Lorke Associate Professor: Dr E Mensah-Brown Research by Dr S Shehab Eric Mensah-Brown has continued to be focused on the Medical Research mechanisms underlying autoimmune type 1 disease and the Specialist: role of microglia in experimental allergic encephalomyelitis (EAE). Mr RS Hameed Together wih collaborators in the Medical Microbiology and Dr RR John Immunology Department, we have shown that different Ms A Rifaat mechanisms regulate autoimmunity in C57BL/6 and BALB/c mice. Mr S Singh Using the multiple low dose streptozotocin model and Mr S Tariq cyclophosphamide, we have shown that whileT regulatory cells Mr W Wanniarachi prevent disease in C57BL6 mice, they are completely ineffective Medical Research in controlling diabetogenesis in BALB/C mice which seem to be Technician: controlled by the ST2/IL-33 paradigm of disease. The latter was Mr M Madathil demonstrated by showing that diabetes developed in normally Secretary: resistant BALB/c mice after deletion of the ST2 gene. We have also Ms L Ravindranathan demonstrated in rats that macrophages and dendritic cells, but Office Assistant: not microglia, are antigen presenting cells in EAE.We contend that Mr TV Basheer microglia remain as protective cells in the central nervous system.

Micrographs showing immunoreactivity to dendritic cells 14 days after disease induction in DA rats (Grade 3 disease) (a) and their absence in AO rats (b), which do not develop EAE. Department of Anatomy

The aim of Sherif Karam’s research focuses on the metabolic parameters in experimental some fundamental aspects of stem cell biology diabetes. He also examines the role of and their role in carcinogenesis, particularly in neuropeptides on insulin and glucagon the gastrointestinal tract and mammary glands. secretion from the pancreas, especially in The epithelial lining of these tissues is diabetic conditions. Recent results from his characterized by continuous production of new laboratory showed that visfatin is expressed in cells and loss of old cells by apoptosis. The many cells located in the central region of source of this continual cell renewal is a small pancreatic islet. The expression of visfatin is population of stem cells that are able to reduced significantly in pancreatic islet cells of proliferate and differentiate as required into diabetic rats compared to control. Visfatin the appropriate cell types. We are interested in appears to co-localize with insulin in pancreatic defining the molecules that regulate stem cells islet cells of normal rats. Visfatin is an adipose in the steady state, which are also those that are tissue hormone implicated in the pathogenesis perturbed during cancer development. of diabetes mellitus and its complications. The presence of visfatin in islet cells shows that Ernest Adeghate’s major research interest is visfatin may have a role to play in the on the effect of pancreas transplantation on metabolism of insulin.

Immunofluorescence images of pancreatic islets showing visfatin (red) and glucagon (green) immunopositive cells in normal (left) and diabetic (right) Wistar rats. Note that visfatin-immunoreactive cells are observed reduced significantly in the islet of Langerhans in diabetic rats.

2 Department of Anatomy

Jerry Buzzell’s research has benefited from cooperation with the Central Veterinary Research Laboratory in Dubai, and involves studies on the histology of the third eyelid and the pleural edge of the dromedary camel. He is also returning to his parasitological roots by investigating the surface anatomy of the larval form of a Habronema muscae, a nematode parasite of flies and horses.

Safa Shehab studies the reorganisation of the Habronema muscae larva neuronal circuitry in the dorsal horn of the spinal cord after peripheral nerve section. His findings do not support the notion that peripheral nerve section causes sprouting of either injured or adjacent uninjured primary afferents in the dorsal horn. He is currently investigating the pain pathways that are likely to be critical in the production of the neuropathic pain. He is characterises neurotransmitter expression in the also investigating the role of the basal ganglia central nervous system of different vertebrates in suppressing epileptic seizures. His recent and studies apoptotic cell death as well as findings showed that the subthalamic nucleus neurotransmitter changes during aging and in might not have critical role in suppressing tonic Alzheimer’s disease. In addition, he is involved in seizure. He is currently investigating whether cooperative clinical research, performing high frequency stimulation of the substantia experimental studies on the development, nigra can produce anticonvulsant effects, using imaging and therapy of malignant tumours and an animal model of epilepsy. on the morphological basis of injuries of the musculoskeletal system. Dietrich E. Lorke’s main research activities are in the area of neuroembryology. He studies developmental changes in the expression of neurotransmitters (GABA, catecholamines), of receptors (glycine receptor, nicotinic acetylcholine receptor, NMDA receptor, estrogen receptor-related receptor) and of functional parameters (functional MRI, c-fos) in different brain regions of rodents and humans. Together with his collaborators in Hamburg, he demonstrated that the transcription factor Nkx6.1 is not only required for the early specification of cranial motoneuron progenitors, but also controls their migration and axonal pathfinding. This collaboration also includes the investigation of altered brain development in mutant mouse strains, including knock-out mice, and studies on the reaction to injury in the spinal cord of mutant mice. His second research interest is concerned with the blood-brain barrier. In collaboration with the Department of Pharmacology, FMHS, he analyses factors influencing the passage of oximes into the brain. Oximes are important adjunct therapeutics in the treatment of organophosphorus poisoning. Together with his colleagues in Hong Kong, he

3 Department of Anatomy

Articles in Peer- gastric cancer. Ann N Y Acad Sci trimedoxime, methoxime and HI- reviewed Journal 1138; 162-168. 6. Clin Toxicol (Phila) 23; 1-7. Karam SM, Tomasetto C, Rio MC Nurulain SM, Lorke DE, Hasan MY, Adeghate E. (2008). Visfatin: (2008) Amplification and Shafiullah M, Kuca K, Musilek K, structure, function and relations invasiveness of gastric epithelial Petroianu GA (2008) Efficacy of to diabetes mellitus and other progenitors during eight experimental bispyridinium dysfunctions. Current Medicinal carcinogenesis in TFF1-knockout oximes against paraoxon-induced Chemistry 15; 1851-1862. mice. Cell Proliferation 41; 923- mortality: Comparison with the 935. conventional oximes pralidoxime Adeghate E, Sótonyi P, Kalász H. and obidoxime. Neurotox Res 14; 1- (2008). Chronic experimental Morrison JF, Shehab S, Sheen R, 9. diabetes accelerates urinary Dhanasekaran S, Shaffiullah M, elimination of deprenyl and its Mensah-Brown E. (2008). Sensory Polgar E, Al-Khater KM, Shehab metabolites. The Open Medicinal and autonomic nerve changes in S, Watanabe M, Todd AJ. (2008) Chemistry Journal 2; 1-5. the MSG-treated rat: A model of Large projection neurons in type II diabetes. Experimental lamina I of the rat spinal cord that Al-Dhaheri WS, Hassouna I, Al- Physiology. 93:213-22. lack the neurokinin 1 receptor Salam S, Karam SM (2008) are densely innervated by Characterization of breast cancer Lorke DE, Hasan MY, Arafat K, VGLUT2-containing axons and progression in the rat. Ann N Y Kuãa K, Musilek K, Schmitt A, possess GluR4-containing AMPA Acad Sci 1138; 121-131. Petroianu GA (2008) In vitro receptors. Journal of oxime protection of human red Neuroscience 28; 13150 –13160. Farook V, AlKhalaf M, Karam SM blood cell acetylcholinesterase (2008) Establishment of a gastric inhibited by diisopropyl- Raza H, John A, Brown EM, epithelial progenitor cell line fluorophosphate. J Appl Toxicol Benedict S, Kambal A. (2008). from a transgenic mouse 28; 422-429 Alterations in mitochondrial expressing the Simian virus 40 respiratory functions, redox large T antigen gene in the Lorke DE, Hasan MY, Nurulain SM, metabolism and apoptosis by parietal cell lineage. Cell Shafiullah M, Nagelkerke N, oxidant 4 - hydroxynonenal and Proliferation 41; 310-320. Petroianu GA (2008) Effect of antioxidants curcumin and intrathecal pralidoxime melatonin in PC12 cells. Fernandez-Cabezudo MJ, administration upon survival of Toxicology and Applied Azimullah S, Nurulain SM, rats exposed to the Pharmacology. 226:161-8. Mechkarska M, Lorke DE, Hasan organophosphate paraoxon. MY, Petroianu GA, Al-Ramadi BK. Neurotoxicology 29; 663-670. Schumacher U, Lukacs Z, (2008) The organo-phosphate Kaltschmidt C, Freudlsperger C, paraoxon has no demonstrable Lorke DE, Nurulain SM, Hasan MY, Schulz D, Kompisch K, Müller R, effect on the murine immune Kuãa K, Musilek K, Petroianu GA. Rudolph T, Santer R, Lorke DE, system following subchronic low (2008) Eight new bispyridinium Ullrich K. (2008) High dose exposure. Int J oximes in comparison with the concentrations of phenylalanine Immunopathol Pharmacol 21; conventional oximes pralidoxime stimulate peroxisome 891-901. and obidoxime: in vivo proliferator-activated receptor efficacy to protect from gamma: Implications for the Giannakis M, Chen SL, Karam SM, diisopropylfluorophosphat pathophysiology of Engstrand L, Gordon JI (2008) e toxicity. J Appl Toxicol 28; 920- phenylketonuria. Neurobiol Dis Helicobacter pylori evolution 928. 32; 385-390. during progression from chronic atrophic gastritis to gastric cancer Lorke DE, Ip CW, Schumacher U. Shehab SAS, Al-Marashda K, Al- and its impact on gastric stem (2008) Increased number of Zahmia A, Abdul-Kareema A, Al- cells. Proceedings of the National microglia in the brain of severe Sultan, MAH. (2008) Academy of Sciences USA 105; combined immunodeficient (SCID) Unmyelinated primary afferents 4358-4363. mice. Histochem Cell Biol 130; 693- from adjacent spinal nerves 697. intermingle in the spinal dorsal Howarth FC, Jacobson M, horn: A possible mechanism Shafiullah M, Adeghate E. (2008). Lorke DE, Hasan MY, Nurulain SM, contributing to neuropathic pain. Long-term effects of type 2 Kuãa K, Schmitt A, Petroianu GA. Brain Research 1208; 111-119. diabetes mellitus on heart (2008) Efficacy of two new rhythm in the Goto-Kakizaki rat. asymmetric bispyridinium oximes Experimental Physiology 93; (K-27 and K-48) in rats exposed to k 362-369. diisopropylfluorophosphate (DFP): comparison with Karam SM (2008) Cellular origin of pralidoxime, obidoxime,

4 Department of Anatomy

Langer R, Usmani A, v. Gorkom K, Books, Chapters, Nurulain SM, Petroianu G, Lorke Research Grants Reviews and DE, Azimullah S. (2008) In vitro study of the efficacy of adding FMHS Research Grants Editorials antibiotics to contrast media at discography to inhibit bacterial Prof DE Lorke. Investigation of the Lorke DE, Kalasz H; Petroianu GA, growth. Radiology, 249, Suppl: 976. development of nephrogenis Tekes K. (2008) Entry of oximes systemic fibrosis (NSF) after intra- into the brain: A Review. Curr Med Lorke DE, Schreiber J, Schumacher peritoneal administration of Chem. 15; 743-753. U (2008) ECM changes after spinal gadolinium-based contrast agents cord hemisection in Tenascin C- (GBCA). Petroianu GA, Lorke DE. (2008) knockout. Matrix Biology 27, Pyridinium oxime reactivators of Suppl. 1: 42 Dr E Mensah-Brown. The effects of cholinesterase inhibited by Toll-like receptor-2 ligand, diisopropyl-fluorophosphate peptidoglycan on the development (DFP): Predictive value of in-vitro of autoimmune diabetes: An testing for In-Vivo efficacy. Mini k analysis in multiple low dose Rev Med Chem. 8; 1328-42. streptozotocin-induced diabetes in wild type mice, interferon- k Proceedings, gamma and iNOS deficient mice. Conferences, Dr S Shehab. Neurochemical Invited lectures, plasticity in the dorsal horn of the spinal cord following the fifth Published Web Sites and lumbar spinal nerve injury. A Abstracts Others possible mechanism contributing letters and to neuropathic pain. Adeghate E, Hameed R, Shafiullah UAEU Individual Grants Correspondence M, Ali Al Kuwaiti A, Fayez Al Qassimi A, Saeed Al Shehhi F, Adeghate E, Hameed R, Shafiullah Prof E Adeghate. Effect of visfatin Mabkhout Al Sayeri N. (2008) M, Ali Al Kuwaiti A, Fayez Al and adiponectin on the metabolic Localization of gamma- Qassimi A, Saeed Al Shehhi F, parameter of diabetic rats aminobutyric acid and glutamic Mabkhout Al Sayeri N. (2008). acid decarboxylase in the Localization of gamma- Prof DE Lorke. In Vitro Study of the endocrine pancreas of Type 1 and aminobutyric acid and glutamic Efficacy of Adding Antibiotics to Type 2 animal models of diabetes. acid decarboxylase in the nonionic Contrast Media for 7th International Diabetes endocrine pancreas of Type 1 and intradiscal use at Discography in Federation Western Pacific Region Type 2 animal models of diabetes: order to reduce Bacterial Growth. Congress, Wellington, New 7th International Diabetes Zealand. Federation Western Pacific Region Dr E Mensah-Brown. Antigen Congress. Diabetes Res Clin Pr 79 presentation and CNS immune- Karam SM, Tomassetto C, Rio MC (Suppl. 1); S59-S60. mediated inflammation: The role (2008) Trefoil factor 1 controls of dendritic cells in experimental proliferation and differentiation Hasan MY, Lorke DE, Nurulain SM, allergic encephalomyelitis. of gastric stem cells. International Kuca K, Schmitt A, Petroianu GA Congress on Cell Biology. Seoul, (2008) Efficacy of two new UAEU Interdisciplinary Grants South Korea. asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to Prof SM Karam. Karam SM (2008) Interaction of diisopropylfluorophosphate (DFP): Ghrelin and recovery after anti- Helicobacter pylori and gastric Comparison with the established neoplastic and cytotoxic therapy cancer stem cells. The 3rd Al-Ain oximes pralidoxime, obidoxime, International Immunology trimedoxime, methoxime and Hi- Sheikh Hamdan Award for Conference, Al-Ain, UAE. 6. Clin Toxicol 46; 397-398. Medical Sciences Karam SM (2008) Relationship Hasan MY, Lorke DE, Arafat K, Kuca Prof E Adeghate. between gastric epithelial stem K, Musilek K, Schmitt A, Petroianu Effect of pancreatic beta cell cells and gastric carcinogenesis. GA (2008) In vitro oxime protection transplantation on the metabolic The 2nd Emirates Pathologists of red blood cell parameters of diabetic rats. Meeting, Dubai, UAE. acetylcholinesterase inhibited by diisopropyl-fluorophosphate. Clin Dr S Shehab. Toxicol 46; 397. Does high frequency stimulation k of the substantia nigra suppress

5 Department of Anatomy

tonic epileptic seizures? Terry Fox Fund for Cancer Research

Prof SM Karam. Role of gastric epithelial progenitors in gastric carcinogenesis

Prof SM Karam. Characterization of the early stages of mammary gland carcinogenesis

National Research Foundation

Prof SM Karam. Stem cell genes and gastric carcinogenesis k

Standing left to right: Safa Shehab, Eric Mensah-Brown, Rasheed Hameed, Saeed Tariq, Sherif Karam, Dietrich Lorke, Mohammed Madathil, Gerald Buzzell, Tayeb Mohamed, Ernest Adeghate. Seated left to right : Sarabjit Singh, WAJ Wanniarachi, Rony John, Laurence Garey (visiting Professor), Lakshmi Ravindranathan, Afaf Rifaat, TV Basheer. 2008Anatomy

http://www.fmhs.uaeu.ac.ae/Departments/Anatomy tel: 7672000 / Fax: 7672033

6 Department of Biochemistry

Research Profile Professor & Chair: Prof J M Conlon Professor: October, 2008 saw the return of Prof. J. Michael Prof H Raza Conlon from exile in Doha to resume his position Associate Professor: D. S Galadari as departmental chair. Prior to this time, Prof. Dr O M A El-Agnaf Haider Raza had served with distinction as acting Assistant Professor: chair. Dr Sehamuddin Galadari was appointed Dr A H Al-Marzouqi Dr M J Fernandez- Associate Dean for Research and Graduate Studies Cabezudo and Dr Omar El-Agnaf assumed the chairmanship Medical Research of the Neuroscience Research Priority Group. Specialist: Dr M Patel Ms M Mechkarska Mr M Qureshi Ms E Ahmed Molecular toxicology and cellular oxidative stress Ms N Al-Ghafari (Prof. H. Raza) Ms. A John My research is mainly focused on mitochondrial dysfunction in Medical Research oxidative stress conditions caused by chemicals, drugs, diseases Technician: and toxicity. I am using whole animal, cell culture and molecular Mr A Qader models in these studies. In this regard, I have interdepartmental Secretary: collaboration with other faculty members and also have Ms K Al-Baloushi developed an international collaboration with the University of Pennsylvania, Philadelphia, USA. In addition, I am also investigating the mechanisms of molecular/cellular defense against toxicity and/or diseases in oxidative stress-related complications by using known phytochemicals and dietary antioxidants.

Research Highlights: In our recent studies, we have demonstrated that mitochondrial dysfunction is tightly coupled to cell survival and apoptosis. Alterations in mitochondrial redox and respiratory metabolisms were found to be critical during oxidative stress. Some of our recent publications have highlighted the significant role of dietary antioxidants, such as EGCG (green tea), black tea polyphenols and curcumin to modulate cellular growth and functions. Department of Biochemistry

Mechanisms of transcriptional Protein misfolding and regulation by chromatin-modifying neurodegenerative diseases (Dr. complexes (Dr. A.H. Al-Marzouqi) O.M.A. El-Agnaf) The overall goal of my research is to understand Pathological studies in human neurodegenerative the basic concepts of how genes are controlled diseases such as Alzheimer's disease (AD), and how that affects cancer development. Our Parkinson’s disease (PD), dementia with Lewy genome is under the control of multiple bodies (DLB), the prion dementias (e.g. mad cow mechanisms. One of them is the control of the disease and its equivalent, CJD, in humans), British packaging of the DNA in our cells and involves dementia and Huntington’s disease, have revealed the chromatin-modifying protein complexes. abundant protein deposits (‘amyloid’) in the Defects in these proteins lead to the affected neurones. There is now substantial development of cancers such as leukemias and evidence from molecular genetics, transgenic lymphomas and some others. These protein animal and biochemical studies to suggest that complexes have been found to interact with the conversion of these amyloid proteins from some known tumor suppressors and oncogenic soluble monomers to aggregated, insoluble forms proteins showing that the chromatin remodeling in the brain is a key event in the pathogenesis of is important for cell regulation. We have been these diseases. This led us to hypothesize that studying the functions of these modifying small molecules that can block and/or reverse complexes in order to understand how they amyloid protein aggregation, particularly in its regulate genes and how their misregulation early stages, would provide an attractive leads to cancer formation. We are also interested therapeutic approach for targeting the underlying in identifying new chromatin-remodeling disease progression of neurodegenerative disease. proteins. These findings might be used in the Our research is concerned with the mechanism future to help cure some types of cancers. of formation and deposition of protein aggregates in these various diseases, and on Research Highlights: (1) Investigation the the potential relationship between protein importance of the Swi2/Snf2 bromodomain for aggregation, neurodegeneration and cell loss. the binding of the complex to acetylated We are also very interested in novel approaches nucleosomes. (2) Purification the SWI/SNF- to improved diagnosis and therapy for these related chromatin remodeling protein Fun30, diseases. A further aspect of our research is the and (3) Testing its DNA and chromatin binding development of novel techniques for detecting in vitro. amyloid aggregates, particularly in their early

Binding of SWI/SNF and Fun30 to GUB DNA and mononucleosomes.

8 Department of Biochemistry stages. We are assessing these methods for Peptides with therapeutic potential the detection of aggregated forms of Aβ and from frog skin (Prof. J.M. Conlon) α-synuclein in CSF and plasma samples from AD, The skins of certain species of frogs represent an PD and DLB patients as an aid to diagnosis of important source of biological active peptides these diseases. Our work also involves the that have the potential for development in development of peptide and non-peptide therapeutically valuable pharmaceutical agents. inhibitors of amyloid aggregation and toxicity These include bactericidal and fungicidal as potential novel therapeutics for these peptides as anti-infectives, peptides with potent neurodegenerative diseases. cytolytic activity against tumor cells as anti- cancer agents, and peptides with in vitro and in Research Highlights: We recently developed a vivo insulin-releasing activities as therapy for simple and novel ELISA method that patients with Type 2 diabetes. specifically recognizes only oligomeric species of α-synuclein. We employed this method to Research Highlights: A peptide belonging to probe for oligomeric forms of α-synuclein in the brevinin-2 family (brevinin-2GUb) from the human brain lysates. Interestingly, based on skin of the Asian frog Hylarana güntheri our results, the ELISA was able to detect α- (Ranidae) and a peptide of the phylloseptin synuclein oligomers in post mortem brain family (phylloseptin-L2) from the skin of the lysates from DLB patients, but, in contrast, only frog South American Hylomantis lemur a very weak signal was obtained from all control (Phyllomedusinae) stimulated the release of and AD samples tested (Paleologou, et al., 2009). insulin from BRIN-BD11 clonal β-cells at sub- Our data add further support to the idea that micromolar concentrations that were not toxic soluble oligomeric forms of α-synuclein play an to the cells. Both peptides when administered important role in the pathogenesis of the PD and to mice significantly (P < 0.05) increased total DLB.The methods developed in our laboratory release of insulin and improved glucose provide a reliable and sensitive technique for the tolerance during the 60 min period following an assay of α-synuclein oligomers in tissue extracts intraperitoneal injection of glucose. and body fluids that will be useful in many future studies.

Frogs of the Year- Hylomantis lemur (left) and Hylarana güntheri (right)

9 Department of Biochemistry

Modulation of the activation and Research Highlights. We have recently function of immune-competent demonstrated that exposure to some OPCs can cells by organophosphorus modulate the immune system of the host in compounds. (Dr. M.J. Fernandez- response to bacterial infections. The exact Cabezudo) mechanism(s) by which the OPCs mediate their My main research interest is the investigation of effect is currently under investigation. the effect of organophosphorus compounds Preliminary evidence indicates this on the immune system. Organophosphorus immunomodulation may well be due to changes compounds (OPCs) are extensively used as in AChE levels, suggesting a functional link between pesticides throughout the world. Toxic effects the nervous and immune systems. of the OPCs are due to inhibition of Differential activation of macrophages, the principal acetylcholinesterase (AChE) in the central and cells of the innate immune system, is currently one peripheral nervous system, with a consequent of the most intriguing subjects in that field. By increase in the levels of the neurotransmitter modulating the activity of these cells, it is possible acetylcholine (ACh) that leads to cholinergic to alter completely their effector functions, for hyperstimulation. Compared to the well- example from a predominantly pro-inflammatory documented neurological consequences of mediator (as in rheumatoid arthritis) to a cell that exposure to OPCs, the data on their potential can actively suppress immune responses (as in effect on the immune system remain tumor tissue). The potential of modulating controversial. We have recently demonstrated macrophage activity and function is an area of that paraoxon, a bioactive metabolite of the research interest in my laboratory.The approach that organophosphate pesticide parathion, is able to we have developed is to study the consequences modulate dramatically the immune response of the interaction between cytokine-expressing through its inhibitory effect on AChE activity. bacterial strains and macrophages, either using Another area of interest in my laboratory is to transformed macrophage cell lines or primary investigate signaling pathways in macrophages, peritoneal macrophages. We have so far the principal cells involved in the innate immune demonstrated the utility of this approach and we response. We are trying to elucidate the plan to continue to explore the specific intracellular biochemical mechanisms that govern the signaling pathways which are induced by the interaction between macrophages and bacterial different bacterial strains. pathogens.

Erythrocyte acteylcholinesterase (RBC- AChE) activity (expressed as percent of baseline) is inversely correlated with the percentage of survival following lethal infection. BALB/c mice were exposed to paraoxon (40 nmols/day) for different lengths of time, as indicated. Blood was collected weekly and analyzed for AChE activity. For survival studies, mice exposed to paraoxon for 1, 2, 3 or 6 weeks were challenged with a lethal dose of a virulent Salmonella strain and scored for survival for up to 60 days. The overall survival for each group is shown in comparison to control mice (0 weeks of exposure).

10 Department of Biochemistry

Signal transduction pathways and disease (Dr. Sehamuddin Galadari) Cellular homeostasis is dependent upon an array of intracellular communication pathways. Cells need to receive signals and send signals, and in that way they communicate with one another at the molecular level. This is achieved by an intricate network of enzymatically regulated biochemical signal pathways prone to regulation by specific messages. If one or more of these enzymes are abrogated or over-subscribed, then disease is set. Indeed, this is what happens at the molecular level of diseases such as cancer, where normal cell growth runs out of control, either due to over subscription of the growth signaling pathway or under subscription of the cell death signaling pathway, both of which may occur following deregulated activity Ceramide (cer) a pro-death lipid © of some enzymes in that pathway, thus leading to tumor formation. Our research effort is focused on studying the following:

Sphingolipids, a novel group of putative second messengers, their putative targets, and the enzymes that produce them. In particular, our effort is focused on ceramide, sphingosine, and sphingosine 1- phosphate, as well as, their targets. This group of messengers play vital signaling role in apoptosis, angiogenesis and stress responses. 0 15 30 60 120 180 (Time in min) We are applying the tools of molecular cell biology as well as classical biochemistry to elucidate the function of these messengers, the enzymes that generate them, and their targets.

Phytochemicals, are naturally occurring compounds that are extracted from fruits, vegetables, and herbs. Increasingly, evidence is being provided as to their importance in health.To that end, we are investigating the effects of different natural products on lipid signaling pathways involved in diseases such as cancer and diabetes.

Research Highlights. We have been investigating neutral ceramidases which regulate the levels of ceramide, sphingosine, and sphingosine 1-phosphate. Recently, we have purified the human neutral ceramidase from human cervical cancer cells and we are currently characterizing the reverse ceramidase activity of this Reverse activity of recombinant neutral ceramidase enzyme.

11 Department of Biochemistry

Biotechnology and Pharmacy, 2; (2008). The organophosphate Articles in Peer- 226-238. paraoxon has no demonstrable reviewed Journals effect on the murine immune Conlon JM. (2008). "Liberation" of system following subchronic low urotensin II from the teleost dose exposure. International urophysis: An historical overview. Journal of Immunopathology and Abdel-Wahab YHA, Power GJ, Flatt Peptides, 29; 651-657. Pharmacology 21; 891-901. PR, Woodhams DC, Rollins-Smith LA, Conlon JM. (2008). A peptide Conlon JM. (2008). A proposed Galadari S, Thayyullathil F, Hago A, of the phylloseptin family from nomenclature for antimicrobial Patel M, Chathoth S. (2008). Akt the skin of the frog Hylomantis peptides from frogs of the genus depletion is an important lemur (Phyllomedusinae) with Leptodactylus. Peptides, 29; 1631- determinant of L929 cell death potent in vitro and in vivo insulin- 1632. following heat stress.Annals of the releasing activity. Peptides, 29; New York Academy of Sciences 2136-2143. Conlon JM. (2008). Reflections on 1138; 385-392. a systematic nomenclature for Abdel-Wahab YH, Power GJ, Ng antimicrobial peptides from the Irvine GB, El-Agnaf OMA, Shankar MT, Flatt PR, Conlon JM. (2008). skins of frogs of the family GM, Walsh DM. (2008). Protein Insulin-releasing properties of the Ranidae. Peptides, 29; 1815-1819. aggregation in the brain - the frog skin peptide pseudin-2 and its molecular basis for Alzheimer's [Lys18]-substituted analogue. Conlon JM, Galadari S, Raza H, and Parkinson's Diseases. Biological Chemistry, 389; 143- Condamine E. (2008). Design of Molecular Medicine 14; 451-64. 148. potent, non-toxic antimicrobial agents based upon the naturally Kawasaki H, Iwamuro S, Goto Y, al-Ramadi BK, Fernandez- occurring frog skin peptides, Nielsen PF, Conlon JM. (2008). Cabezudo MJ, El-Hasasna H, Al- ascaphin-8 and peptide XT-7. Characterization of a hemolytic Salam S, Attoub S, Xu D, . Chouaib Chemical Biology and Drug protein, identified as histone H4, S. (2008). Attenuated bacteria as Design, 72; 58-64. from the skin of the Japanese tree effectors in cancer frog Hyla japonica (Hylidae). immunotherapy. Annals of the Conlon JM, Leprince J, Vaudry H, Comparative Biochemistry and New York Academy of Sciences, Coquet L, Jouenne T, Kolodziejek Physiology B 149; 120-125. 1138; 351-357. J Nowotny N, King JD. (2008). Characterization of antimicrobial Kawasaki H, Koyama T, Conlon Anderson WG, Leprince J, Conlon peptides from the skin secretions JM,Yamakura F, Iwamuro S (2008) JM. (2008). Purification, structural of the Malaysian frogs, Odorrana Antimicrobial action of histone characterization, and myotropic hosii and Hylarana picturata H2B in Escherichia coli: evidence activity of a peptide related to (Anura: Ranidae). Toxicon, 52; 465- for membrane translocation and des-Arg9-bradykinin from an 473. DNA-binding of a histone-2B elasmobranch fish, the little skate, fragment after proteolytic Leucoraja erinacea. Peptides, 29; Conlon JM, Power GJ, Abdel- cleavage by outer membrane 1280-1286. Wahab YHA, Flatt PR, Jiansheng proteinase T1. Biochemie 90; H, Coquet L, Leprince J, Jouenne 1693-1702. Austen BM, Paleologou KE, Ali SAE, T, Vaudry H. (2008). A potent, non- Qureshi MM, Allsop D, El-Agnaf toxic insulin-releasing peptide King JD, Leprince J, Vaudry H, OMA. (2008). Designing peptide isolated from an extract of the skin Coquet L, Jouenne T, Conlon JM. inhibitors for oligomerization and of the Asian frog, Hylarana (2008). Purification and toxicity of Alzheimer’s ‚-amyloid güntheri (Anura:Ranidae). characterization of antimicrobial peptide. Biochemistry, 47; 1984- Regulatory Peptides, 151; 153- peptides from the Caribbean frog, 1992. 159. Leptodactylus validus (Anura:Leptodactylidae). Peptides Awad S, Hassan AH. (2008). The Eley A, Ibrahim M, Kurdi SE, Conlon 29; 1287-1292. Swi2/Snf2 Bromodomain Is JM. (2008). Activities of the frog Important for the Full Binding and skin peptide, ascaphin-8 and its Le Mével JC, Lancien F, Mimassi N, Remodeling Activity of the lysine-substituted analogs against Leprince J, Conlon JM, Vaudry H. SWI/SNF Complex on H3- and H4- clinical isolates of extended- (2008). Central and peripheral acetylated Nucleosomes. Annals spectrum beta-lactamase (ESBL) cardiovascular, ventilatory, and New York Academy of Sciences, producing bacteria. Peptides 29; motor effects of trout urotensin- 1138; 366-375. 25-30. II in the trout. Peptides. 29; 830- 837. Chathoth S, Thayyullathil F, Fernandez-Cabezudo MJ, Galadari S. (2008). Curcumin cell Azimullah S, Nurulain SM, Mollenhauer B, Cullen V, Kahn I, signaling: a possible target for Mechkarska M, Lorke DE, Hasan Krastins B, Outeiro TF, Pepivani I, chemotherapy, Current Trends in MY, Petroianu GA, al-Ramadi BK. Ng J, Schulz-Schaeffer W,

12 Department of Biochemistry

Kretzschmar HA, McLean PJ, PL, Martin FL. (2008). Elevated Mechanisms of the anti-cancer Trenkwalder C, Sarracino DA, expression of CYP1A1 and activity of the clove extract. 9th Vonsattel JP, Locascio JJ,El-Agnaf gamma-synuclein in human UAEU conference, Al-Ain, UAE. OMA, Schlossmacher MG. (2008). ectopic (ovarian) endometriosis Direct quantification of CSF alpha- compared to eutopic Conlon JM. (2008). Dermal synuclein by ELISA and first cross- endometrium. Molecular Human peptides and the system of sectional study in patients with Reproduction 14; 655-663. innate immunity in amphibians. neurodegeneration. Experimental State-of-the-Art Lecture, 22nd Neurology 213; 315-25. Subasinghage AP, Conlon JM, Conference of European Hewage CM. (2008). Comparative Endocrinologists, Raza H, John A, Brown EM, Conformational analysis of the Genoa, Italy. Benedict S, Kambal A. (2008). broad-spectrum antibacterial Alterations in mitochondrial peptide, ranatuerin-2CSa: El-Hasasna, H, Fernandez- respiratory functions, redox Identification of a full length helix- Cabezudo MJ, Al-Salam S, Bashir metabolism and apoptosis by turn-helix motif. Biochimica G, Attoub S, Chouaib S, al- oxidant 4-hydroxynonenal and Biophysica Acta 1784; 924-929. Ramadi BK. (2008). The anti- antioxidants curcumin and tumor activity of systemically- melatonin in PC12 cells. Thayyullathil F, Chathoth S, Hago administered IL2-expressing Toxicology and Applied A, Wernery U, Patel M, Galadari S. Salmonella correlates with Pharmacology 226; 161-168. (2008). Investigation of heat stress decreased angiogenesis and response in the camel fibroblast enhanced tumor apoptosis. The Raza H, John A. (2008). In vitro cell line dubca. Annals of the New 3rd Al-Ain International effects of tea polyphenols on York Academy of Sciences 1138; Immunology Meeting, Al-Ain, redox metabolism, oxidative stress 376-384. UAE. and apoptosis in PC12 cells. Annals of the New York Academy Thayyullathil F, Chathoth S, Hago El-Hasasna H, Fernandez- of Sciences 1138; 358-365. A, Patel M, Galadari S. (2008). Cabezudo MJ, El-Wasila M, Al- Rapid reactive oxygen species Salam S, Bashir G, Chouaib S, Rizk DE, Hassan HA, Al-Marzouqi (ROS) generation induced by al-Ramadi BK. (2008). Oral AH, Ramadan GA, Al-Kedrah SS, curcumin leads to caspase- administration of TNF·- Daoud SA, Fahim MA. (2008). dependent and -independent expressing Salmonella inhibits Combined estrogen and ghrelin apoptosis in L929 cells. Free melanoma cell growth and administration restores number Radical Biology and Medicine 45; prolongs host survival of blood vessels and collagen type 1403-1412. independent of intra-tumoral I/III ratio in the urethral and anal bacterial accumulation. The 3rd canal submucosa of old Al-Ain International Immunology ovariectomized rats. International k Meeting, Al-Ain, UAE. Urogynecology Journal and Pelvic Floor Dysfunction 19, 547-552. Fernandez-Cabezudo MJ, Ullah A, Nurulain SM, al-Ramadi BK, Rizk DE, Hassan HA, Al-Marzouqi Proceedings, Petroianu GA. (2008). AH, Shafiullah M, Fahim MA. Conferences, Assessment of immunologic (2008). Combined estrogen and parameters following exposure ghrelin administration decreases Invited lectures, to organophosphate-containing expression of p27(kip1) and Web Sites and pesticides. The 3rd Al-Ain proportion of isomyosin type I in Immunology Meeting, Al-Ain, the striated urethral and anal Others UAE. sphincters and levator ani of old ovariectomized rats. International Attoub S, Al-Salam S, John A, Hassan AH, Awad S., Prochasson Urogynecology Journal and Pelvic Manjush S, Al Sultan M, Al Safi P., and Owen-Hughes T. (2008). Floor Dysfunction 19; 1363-1369. MM, John A, Raza H, Adem A. Fun 30 is a novel chromatin (2008). Thymoquinone induces remodeling protein with dimer Siddig A, Mohamed AO, Awad S, human cancer cell death and exchange activity that interacts Hassan A, Zilahi E, Al-Haj M, tumor growth inhibition. with ubiquitinated histones. Bernsen R, Adem A. (2008). American Association for Cancer Gordon Conference on Estrogen Receptor · Gene research (AACR) sponsored Chromatin Structure & Function Polymorphism and Breast cancer. International Conference on in Lucca (Barga), Italy. Annals of the New York Academy “Advances in Cancer Research: of Sciences 1138; 95-107. from the Laboratory to the Mechkarska M, al-Ramadi BK, Clinic”. Dead Sea, Jordan. Fernandez-Cabezudo MJ. (2008). Singh MN, Stringfellow HF,Taylor Invasion-Independent SE, Ashton KM, Ahmad M, Abdo Awad S, Al-Marzouqi A, Rizvi Modulation of Macrophage KR, El-Agnaf OMA, Martin-Hirsch TA, Hassan AH. (2008). Activation by Bacteria-Expressed

13 Department of Biochemistry

Cytokines. The 3rd Al-Ain UAEU University Lewy bodies MRI imaging agents Immunology Meeting, Al-Ain, Interdisciplinary Grants for the early diagnosis of UAE. Parkinson’s disease and related El-Agnaf OMA. Testing novel disorders Ojali SM, Ullah A, Bashir G, El- inhibitors of ·-synuclein Hasasna H, Fernandez-Cabezudo oligomerization and toxicity as a El-Agnaf OMA A strategy to MJ, al-Ramadi BK. (2008). novel treatment for Parkinson's develop a radiotracer targeting Enhancement of immune and related disorders alpha-synuclein responsiveness by attenuated interferon gamma-expressing Conlon JM. Detection and Salmonella vaccine.The 3rd Al Ain characterization of antimicrobial k International Immunology peptides from frog skin using Meeting, Al- Ain, UAE. pyrolysis liquid chromatography mass spectrometry Raza H, John A, Benedict S, Al- Otaiba A. (2008). Aspirin- Terry Fox Fund for Cancer induced cell cycle arrest, Research Grants mitochondrial dysfunction, oxidative stress and apoptosis Al-Marzouqi AH. Investigating in hepatoma HepG2 cells. 47th the mechanisms of action of the Annual Meeting of Society of Snf2-homolog protein Fun30 Toxicology, Seattle, Washington, USA, The Toxicologist Fernandez-Cabezudo MJ. Novel (supplement to Toxicological resistance biomarkers in human Sciences) 102, 1395. breast cancer

Ullah A, El-Hasasna H, Mechkarska M, Flavell R, Sheikh Hamdan Awards for Fernandez-Cabezudo MJ, al- Medical Research Grants Ramadi BK. (2008). Role of MyD88 expression and TLR Al-Marzouqi AH. Characterization signaling in immunity to and functional analysis of the Salmonella infection. The 3rd Al putative chromatin remodeling Ain International Immunology protein Fun30 Meeting, Al-Ain, UAE. El-Agnaf OMA. Designing inhibitors of ·-synuclein oligomerization and k toxicity in cell and animal models: implications for Parkinson's and related disorders therapy

Research Grants Conlon JM. Development of the frog skin peptide temporin-1DRa into a therapeutically valuable FMHS New Research Grants antimicrobial and antitumour agent: a structure-activity study. Conlon JM. Purification and characterization of novel Emirates Foundation Grants antimicrobial peptides from skin secretions of frogs of the Galadari S. Purification and genus Lithobates. (seed grant) characterization of a novel more hydrophobic isoform of Raza H. Impairment of cellular N-acylsphoingosine redox and respiratory functions amidohydrolase by acetaminophen: role of oxidative stress and Michael J. Fox Foundation for glutathione metabolism in the Parkinson’sResearch, USA Grants prevention of toxicity by antioxidants El-Agnaf OMA. Validation of CSF alpha-synuclein as a biomarker Galadari S. Characterization of for Parkinson’s disease. the human neutral ceramidase from Hela cells El-Agnaf OMA Development of

14 Department of Biochemistry

Standing left to right: H Raza, JM Conlon, A Qader, S Galadari, OMA El-Agnaf, Seated left to right: AH Al-Marzouqi, M Patel, A John, M Fernandez-Cabezudo, M Mechkarska, M Qureshi 2008Biochemistry

http://www.fmhs.uaeu.ac.ae/Departments/Biochemistry Tel: 7672000 / Fax: 7672033

15 Department of Community Medicine

Research Profile

Professor & Chair: The Department of Community Medicine has a Prof TC. Aw mission to train health professionals to protect and Professor: Prof N Nagelkerke improve the health of the population of the United Associate Professor: Arab Emirates, with special reference to the Dr P Barss vulnerable. A key element in achieving our Dr R Bernsen *Dr I Blair department's mission is providing good **Dr S Shah information about the main threats to health, Assistant Professor: particularly lifestyle-related chronic diseases, Dr M Grivna Dr J Schneider injury, and infectious diseases. This is the main ***Dr A Wheatley thrust of our research initiatives. Departmental Academic Assistant research expertise includes Epidemiology, Public Dr M El Sadig Medical Research Health, Occupational Health and Biostatistics. Our Specialist: multidisciplinary departmental staff are currently ****Mr H El Agab involved in the following research areas, with Office Assistant Mr M Jamal special emphasis on health issues of importance Medical Secretary: to the UAE: Ms A Kaljee

General Public Health Research: Surveys for infectious diseases include HIV/AIDS prevention, and occupational blood-born diseases. Health surveys to assess awareness about breast cancer, breast and other infant feeding, antenatal care, school hygiene, premarital screening, oral contraceptives, alternative medicine, folic acid intake during pregnancy, smoking hazards, healthy diet * Joined May 2008 and physical activity. Health care administration research includes ** Joined August 2008 patients' satisfaction with primary health care services, perinatal *** Joined August 2008 services and doctor-patient relationship. **** Departed March 2008 Chronic Diseases Prevention Research: Incidence, prevalence and risk factor analysis of asthma, obesity, osteoporosis, anemia, ischemic heart disease, stroke, hypertension, diabetes mellitus and DM complications.

Injury Prevention Research: Incidence and risk factor research Department of Community Medicine of school related traffic injury, home injury, road Netherlands for many years before joining FMHS, crashes and use of safety belts, and drowning. and conducted studies in the Netherlands on risk factors for childhood asthma and allergy. She Occupational Health Research: The Department is organizing related studies in the UAE. has a 1 million USD grant to carry out a 600- household field epidemiology survey on Dr. Iain Blair: Public health specialist physician Environment and Health. This is being done with a background in UK health protection. He jointly with collaborators from the Gillings School has published articles on the surveillance and of Public Health at North Carolina University, control of infectious diseases and has co- Chapel Hill (UNC). The source of funding is the authored a textbook on health protection and Environment Agency of Abu Dhabi (EAD). The several book chapters. His current research field study is part of a larger project involving projects include the molecular epidemiology UNC, RAND Corporation, and our department as of Staphylococcal aureus infection and research partners. occupational health aspects of tuberculosis control. The Health Authority of Abu Dhabi (HAAD) has also awarded a research grant to our department Dr. Mohamed El-Sadig: Epidemiologist and for developing guidelines on preventing heat health economist, with special interest in traffic stress.This is an occupational and environmental safety and non-communicable diseases. He is health issue particularly relevant to the desert currently coordinating a collaborative research climate in the UAE and the surrounding region. project with Monash University Accident Research Center (MUARC) and co-investigating Biostatistics: Our team of statisticians / several safety research projects in collaboration epidemiologists provides advice on study design with stakeholders in the UAE. and statistical analyses to researchers at the Faculty of Medicine and to external Dr. Michal Grivna: Public health specialist organizations including government physician with a special interest in child injury departments and industry. control, school and community safety, bicycle- related and playground injuries and more Research Interests recently school traffic safety, trauma registration Dr. Fatma Al Maskari: Public health physician and HIV/AIDS prevention in the UAE. A founding and epidemiologist with interest in non- member of the European Child Safety Alliance communicable chronic diseases epidemiology and the Centre for Childhood Injury and prevention, lifestyle and health and Epidemiology and Prevention in the Czech evidence-based medicine. She is currently Republic. Dr. Grivna is a leading figure in the involved in research aiming to determine promotion and implementation of "WHO - Safe prevalence of DM complications among patients Community Programs". in Al-Ain. Recently received the best Oral Presentation Award at the First International Prof. Nico Nagelkerke: Senior Biostatistician with Conference for the Study of Diabetes, held in a special interest in statistical methodology and Dubai during February 2005. infectious disease modeling. Prof. Nagelkerke has provided input in biostatistics to a number of Prof. Tar-Ching Aw: US-Board certified in projects which resulted in peer reviewed occupational medicine. He has a special interest publications during 2008. He is collaborating with in occupational toxicology, occupational risks to the Department of Preventive Medicine on a study health-care workers, and training and education. on tuberculosis. Prof. Aw is a member of the International Advisory Board of Occupational Medicine. Dr. John Schneider: Occupational health physician. His main research interests are Dr. Roos Bernsen: Epidemiologist and occupational rehabilitation, organization and Biostatistician with special interest in allergy planning of occupational health services in rural and asthma. She provided consultations to the and remote work sites, work in hot Research Department of the Erasmus Medical environments, and impairment assessment at Center of the University of Rotterdam in the the workplace.

17 Department of Community Medicine

Dr. Syed Shah: Chronic disease epidemiologist the Department has established academic and with research interests in epidemiology of community service relations with the cardiovascular disease, work-related injuries Department of Medical Services of ADCO-Abu and mental health. Dhabi.This has resulted in training opportunities for students in occupational health. The Dr. Andrew Wheatley: Occupational hygienist Department also provides academic input to with a broad-based background in consultancy, the UAEU Masters program of Environmental teaching and research. Research interests include Sciences, the Arab Board Residency Programs, exposure and risk characterization for combustion Medical Laboratory Technology (MLT) Masters processes, metal industries and organic dusts. Degree and various CME programs within and Currently engaged in projects concerned with outside Al-Ain District. the health, safety and welfare of migrant workers in the UAE. The Department provides scientific input to the UAEU collaborative Road Safety Research Visiting Professors during 2008: include Prof. Centre (RTTSRC) which undertakes collaborative Ken Addley from the Faculty of Occupational research with agencies within and outside the Medicine, Royal College of Physicians (Ireland); UAE. and Dr. David Fishwick from the University of Sheffield, UK. Research Training An essential function of training in community Academic Collaboration Within and medicine is field research on target populations Outside the UAE University to assess incidence, prevalence, and risk factors The Department collaborates on clinical research for health, disease, and injury. The Department issues and works closely with the Health Authority provides research training for final year and Abu Dhabi, particularly the Preventive Medicine second year medical students, as well as Department of Al Ain, on projects assessing residents in Family and Community Medicine. infectious diseases, including HIV/AIDS, chronic The faculty members of the Department diseases, injury, mortality reporting and death supervise many field research projects for five certification, and occupational health. In addition, senior clerkship groups every year.

Senior Medical Student District in the UAE. Supervisors: police towards car restraints in Al Clerkship Research Projects Blair I (Principal), Wheatley A. Ain, UAE. Supervisors: Grivna M (Principal), Schneider J, Barss P,El- Adi MMMF, Al Khaili JRM, Al-Shrief Al Kaabi KMS, Al Haj EAIH, Khonji Sadig M, Nagelkerke N. KA. (2008). Women’s awareness, DMA, Al Sharhan RYR. (2008). attitude and practice regarding Prevalence of anxiety, depression Shemaili OM, Al-Rahoomi AM, Al- the risk of baby walkers: an and suicidal behavior among Kuwaiti MH, Al-Kuwaiti AH. (2008). interventional study. Supervisors: residents of labour camps in Al Ain Epidemiology, risk factors, and Grivna M (Principal), El-Sadig M, City, UAE. Supervisors: Al Maskari F prevention of injury from falls seen Bernsen R. & Shah S (Joint Principal), Schneider at hospital emergency J, Bernsen R. departments of Al Ain, United Al Awadhi AMSB, Al Neaimi KAAA, Arab Emirates. Supervisors: Barss Al Hammadi AAKO, Kazim BMMS. Al-Shamsi HS, Al-Ali MH, Al- P (Principal), Grivna M, Bernsen R. (2008). Knowledge, attitude and Hammadi AH, Al-Senani AS, Al- practice of poultry farm workers Obthani MM. (2008). Knowledge, towards avian influenza in Al Ain attitude and practice of traffic

18 Department of Community Medicine

Arab Emirates. The Open Sports risk factors in Al-Ain, United Arab Articles in Peer- Medicine Journal;2: 75-81. Emirates. An emerging health care reviewed Journals priority. Saudi Med J;29(8):1173-8. Al-Kaabi J, Al-Maskari F, Saadi H, Abdulle AM, Nagelkerke N, Afandi B, Parkar H, Nagelkerke N. Bernsen RM, Nagelkerke NJ, Thijs Obineche R,Yasin J, Obineche EN. (2008). Assessment of dietary C, van der Wouden JC. (2008). (2008). Biochemical markers and practice among diabetic patients Reported pertussis infection and lipid profiles in a multiethnic in the United Arab Emirates. The risk of atopy in 8- to 12-yr-old hypertensive population from the Review of Diabetic vaccinated and non-vaccinated United Arab Emirates. Journal of Studies;5(2):110-5. Epub 2008 Aug children. Pediatr Allergy Nephrology and Renal 10. Immunol;19(1):46-52. Transplantation (JNRT) 1; 23-31. Al-Maskari F, El-Sadig M, Obineche Bernsen RM, Nagelkerke NJ. (2008). Abdulle AM, Nagelkerke NJ, E. (2008). Prevalence and Impairment of regulatory T cells Abouchacra S, Obineche EN. determinants of microalbuminuria in cord blood of atopic mothers (2008). Potential benefits of among diabetic patients in the (2008). J Allergy Clin controlling coronary heart disease United Arab Emirates. BMC Immunol;122:841. risk factors in the United Arab Nephrology;29; 9:1. Emirates. Kidney Blood Press Bernsen RM, van der Wouden JC. Res;31(3):185-8. Barss P,Al-Obthani M, Al-Hammadi (2008). Measles, mumps and A, Al-Shamsi H, El-Sadig M, Grivna rubella (MMR) infections and Abdulrazzaq YM, Kendi AA, M. (2008). Prevalence and Issues atopic disorders in MMR- Nagelkerke N. (2008). Child care in Non-Use of Safety Belts and unvaccinated and MMR- practice in the United Arab Child Restraints in a Desert City in vaccinated children. Pediatr Emirates: the ESACCIPS study. Acta the United Arab Emirates. Traffic Allergy Immunol Pediatr Allergy Paediatr;97(5):590-5. Injury Prevention 2008;9:256-263. Immunol;19:544-51.

Abdulrazzaq YM, Moussa MA, Barss P, Djerrari H, Leduc BE, Chandrasekaran P, Dallabetta G, Nagelkerke N. (2008). National Lepage Yves, Dionne CE. (2008). Loo V, Mills S, Saidel T, Adhikary R, growth charts for the United Arab Risk factors and prevention for Alary M, Lowndes CM, Boily MC, Emirates. J Epidemiol.18(6):295- spinal cord injury from diving in Moore J. (2008). Avahan 303. swimming pools and natural sites Evaluation Partners. Evaluation in Quebec, Canada: a 44-year design for large-scale HIV Abdulrazzaq YM, Osman N, study. Accident Analysis & prevention programmes: the case Nagelkerke N, Kosanovic M, Adem Prevention 2008;40:787-797. of Avahan, the India AIDS initiative. A. (2008). Trace element AIDS;22 Suppl 5:S1-15. composition of plasma and breast Barss P, Grivna M, Al-Maskari F, milk of well-nourished women. J Kershaw G. (2008). Strengthening Clatney L, MacDonald H, Shah SM. Environ Sci Health A Tox Hazard public health medicine training (2008). Mental health care in the Subst Environ Eng;43(3):329-34. for medical students: development primary care setting: Family and evaluation of a lifestyle physicians' perspectives. J Adam SH, Eid HO, Barss P,Lunsjo K, curriculum. Medical Teacher; 30 Canadian Family Physicians: Grivna M,Torab FC, Abu-Zidan FM. (9-10):e196-218. 2008;54(6):884-9. (2008). Epidemiology of Geriatric Trauma in United Arab Emirates. Barss P, Subait OM, Al Ali MH, Denic S, Nagelkerke N, Agarwal Archives Gerontology Geriatrics Grivna M. (2008). Drowning in a MM. (2008). Consanguineous 2008;47(3):377-82. high-income developing country: marriages and endemic malaria: newspapers as an essential can inbreeding increase Al-Banna A, Al-Bedwawi S, Al-Saadi resource for injury surveillance. J population fitness? Malar J.;7:150. A, Al-Maskari F, Eapen V. (2008). Sci Med Sport;12:164-170. Prevalence and correlates of Eid HO, Barss P, Adam SH, Torab conduct disorder among inmates Bates G P, Schneider J. (2008). FC, Lunsjo K, Grivna M, Abu-Zidan of juvenile detention centres, Hydration status and physiological FM. (2008). Factors Affecting United Arab Emirates. Eastern workload of UAE construction Anatomical Region of Injury, Mediterranean Health Journal; workers: A prospective Severity, and Mortality for Road 14(5):1054-9. longitudinal observational study. Trauma in a High-Income J Occ Med and Tox 2008; 3:21 Developing Country: Lessons for Al-Falasi O, Al-Dahmani K, Al-Eisaei Prevention. Injury 2008 Dec 29. K, Al-Ameri S, Al-Maskari F, Baynouna LM, Revel AD, [Epub ahead of print] Nagelkerke N, Schneider J. (2008). Nagelkerke NJ, Jaber TM, Omar AO, Knowledge, attitude and practice Ahmed NM, Naziruldeen MK, Al- Ferguson LW, Rajput ML, of anabolic steroids use among Sayed MF, Nour FA. (2008). High Muhajarine N, Shah SM, Rajput A. gym users in Al-Ain District, United prevalence of the cardiovascular (2008). Clinical features at first visit

19 Department of Community Medicine

and rapid disease progression in what are the cultural and linguistic Evenhuis H. (2008). Combined Parkinson's disease. Parkinsonism barriers? Patient Educ sensory impairment (deaf- Relat Disord;14(5):431-5 Couns;72:155-62. blindness) in five percent of adults with intellectual disabilities. Am J Gaƒczak M, Barss P. (2008). Heidema AG, Nagelkerke N. (2008). Ment Retard;113:254-62. Nosocomial HIV infection: Developing a discrimination rule epidemiology and prevention - a between breast cancer patients Moses S, Ramesh BM, Nagelkerke global perspective. AIDS Reviews and controls using proteomics NJ, Khera A, Isac S, Bhattacharjee 2008 Jan-Mar;10(1):47-61. mass spectrometric data: a three- P, Gurnani V, Washington R, step approach. Stat Appl Genet Prakash KH, Pradeep BS, Blanchard Hadi U, Duerink DO, Lestari ES, Mol Biol;7(2):Article5. JF. (2008). Impact of an intensive Nagelkerke NJ, Keuter M, Huis In't HIV prevention programme for Veld D, Suwandojo E, Rahardjo E, HirbodT, Kaul R, Reichard C, Kimani female sex workers on HIV van den Broek P,Gyssens IC. (2008). J, Ngugi E, Bwayo JJ, Nagelkerke N, prevalence among antenatal clinic Antimicrobial resistance in Hasselrot K, Li B, Moses S; Kibera attenders in Karnataka state, south Indonesia: prevalence and HIV Study Group, MacDonald KS, India: an ecological analysis. AIDS prevention – audit of antibiotic Broliden K. (2008). HIV-neutralizing Dec;22 Suppl 5:S101-8. prescribing in two governmental immunoglobulin A and HIV- teaching hospitals in Indonesia. specific proliferation are Peters HO, Mendoza MG, Capina Clin Microbiol Infect;14(7):698-707. independently associated with RE, Luo M, Mao X, Gubbins M, reduced HIV acquisition in Kenyan Nagelkerke NJ, Macarthur I, Hadi U, Duerink DO, Lestari ES, sex workers. AIDS;22(6):727-35. Sheardown BB, Kimani J, Wachihi Nagelkerke NJ, Werter S, Keuter M, C, Thavaneswaran S, Plummer FA. Suwandojo E, Rahardjo E, van den Kimani J, Kaul R, Nagelkerke NJ, (2008). An integrative Broek P, Gyssens IC (2008).; Luo M, MacDonald KS, Ngugi E, bioinformatic approach for Antimicrobial resistance in Fowke KR, Ball BT, Kariri A, Ndinya- studying escape mutations in Indonesia: prevalence and Achola J, Plummer FA. (2008). human immunodeficiency virus prevention study group – survey of Reduced rates of HIV acquisition type 1 gag in the Pumwani Sex antibiotic use of individuals during unprotected sex by Kenyan Worker Cohort. J Virol;82(4):1980- visiting public healthcare facilities female sex workers predating 92. in Indonesia. Int J Infect population declines in HIV Dis;12(6):622-9. prevalence. AIDS;22(1):131-7. Rhodes A, AwTC, Allen C, Ridout M. (2008). Immunisation status of Hardie RA, Knight E, Bruneau B, Lacap PA, Huntington JD, Luo M, dental practice staff in Kent. Br Semeniuk C, Gill K, Nagelkerke N, Nagelkerke NJ, BielawnyT, Kimani Dent J;205(10). Kimani J, Wachihi C, Ngugi E, Luo J, Wachihi C, Ngugi EN, Plummer M, Plummer FA. (2008). A common FA. (2008). Associations of human Saadi H, Nagelkerke N, Carruthers human leucocyte antigen-DP leukocyte antigen DRB with SG, Benedict S, Abdulkhalek S, Reed genotype is associated with resistance or susceptibility to HIV- R, Lukic M, Nicholls MG. (2008). resistance to HIV-1 infection in 1 infection in the Pumwani Sex Association of TCF7L2 Kenyan sex workers. Worker Cohort. AIDS;22(9):1029- polymorphism with diabetes AIDS;22(15):2038-42. 38. mellitus, metabolic syndrome, and markers of beta cell function and Hardie RA, Luo M, Bruneau B, Le Cessie S, Nagelkerke N, insulin resistance in a population- Knight E, Nagelkerke NJ, Kimani J, Rosendaal FR, van Stralen KJ, Pomp based sample of Emirati subjects. Wachihi C, Ngugi EN, Plummer FA. ER, van Houwelingen HC. (2008). Diabetes Res Clin Pract;80(3):392-8. (2008). Human leukocyte antigen- Combining matched and DQ alleles and haplotypes and unmatched control groups in case- Siddig A, Mohamed AO, Awad S, their associations with resistance control studies. Am J Hassan AH, Zilahi E, Al-Haj M, and susceptibility to HIV-1 Epidemiol;168(10):1204-10. Bernsen R, Adem A. (2008). infection. AIDS;22(7):807-16. Estrogen receptor alpha gene Lorke DE, Hasan MY, Nurulain SM, polymorphism and breast cancer. Hardy AD, Farrant AJ, Rollinson G, Shafiullah M, Nagelkerke N, Ann N Y Acad Sci;1138:95-107. Barss P,Vaishnav R. (2008). A study Petroianu GA. (2008). Effect of of the chemical composition of intrathecal pralidoxime Siddig A, Mohamed AO, Kamal H, traditional eye cosmetics ("kohls") administration upon survival of Awad S, Hassan AH, Zilahi E, Al- used in Qatar andYemen. J Cosmet rats exposed to the Haj M, Bernsen R. (2008). HER- Sci 2008 Sep-Oct;59(5):399-418. organophosphate paraoxon. 2/neu Ile655Val polymorphism Neurotoxicology;29(4):663-70. and the risk of breast cancer. Ann Harmsen JA, Bernsen RM, N Y Acad Sci;1138:84-94. Bruijnzeels MA, Meeuwesen L. Meuwese-Jongejeugd A, van Van den Wijngaard C, van Asten L, (2008). Patients' evaluation of Splunder J, Vink M, Stilma JS, van van Pelt W, Nagelkerke NJ, Verheij quality of care in general practice: Zanten B, Verschuure H, Bernsen R, R, de Neeling AJ, Dekkers A, van

20 Department of Community Medicine der Sande MA, van Vliet H, Association, Kuala Lumpur, Koopmans MP.(2008). Validation of 2008;5:43-53. Proceedings, syndromic surveillance for Conferences, respiratory pathogen activity. Williams AN, Aw TC. (2008). Stress Emerg Infect Dis;14(6):917-25. among health care professionals. Invited lectures, In: Occupational Health for Health Web Sites and Van der Wouden JC, Uijen JH, Care Professionals 1st edition (eds. Bernsen RM,Tasche MJ, de Jongste Jayakumar G & Retneswari M), Others JC, Ducharme F. (2008). Inhaled Malaysian Medical Association, Abu-Zidan FM, Eid HO, Lunsjo K, sodium cromoglycate for asthma Kuala Lumpur, 2008;15:179-194. Torab FC, Barss M, Grivna M, in children. Cochrane Database Shaban S, Barka E. (2008). Syst Rev;4:CD002173. Establishment of a road traffic k injury registry in Al Ain city. Faculty Van Rijn RM, van Os AG, Bernsen Research Seminar, FMHS, UAE RM, Luijsterburg PA, Koes BW, University, 12 November 2008, Al Bierma-Zeinstra SM. (2008). What Ain, UAE. is the clinical course of acute ankle Published sprains? A systematic literature Abstracts, Abu-Zidan FM, Eid HO, Lunsjo K, review. Am J Med;121:324-331.e6. Torab FC, Barss M, Grivna M, Letters and Shaban S, Barka E. (2008). Vissers DC, Voeten HA, Nagelkerke Correspondence Establishment of a road traffic NJ, Habbema JD, de Vlas SJ. (2008). collision injury registry in Al Ain The impact of pre-exposure City. Proceedings from the 9th prophylaxis (PrEP) on HIV Arora P,Kumar R, Bhattacharya M, Annual UAE University Research epidemics in Africa and India: a Nagelkerke NJ, Jha P.(2008).Trends Conference, May 2008. simulation study. PLoS ONE in HIV incidence in India from 2000 7;3(5):e2077. to 2007. Lancet;372(9635):289-90. Bernsen RM, Nagelkerke NJ. (2008). Al-Belooshi SH, Al-Hosani SM, Al- Impairment of regulatory T cells Yamahi AR, Al-Zaabi MR, Barss P, k in cord blood of atopic mothers. J Grivna M. (2008). What are the real Allergy Clin Immunol;122(4):841. causes of death in the United Arab Emirates? Proceedings from the Denic S, Nagelkerke N, Nicholls 9th Annual UAE University Books, Chapters, MG. (2008). Germline genomic Research Conference, May 2008. homozygosity and cancer risk. Reviews and JAMA;300(2):169-70. Al-Hammadi S, Al-Maskari F, Editorials Bernsen R. (2008). Prevalence of Nowshad G, Shah SM, Bano R, Alam food allergy among children in Al- S, Alvi A, Jahan N. (2008). Ain City, UAE. Proceedings from Bates G, Schneider J. (2008). Correlates of access to antenatal the 9th UAE University Research Development, and scientific care in villages of Pakistan. Annals Conference, May 2008. validation for Gulf conditions, of of Epidemiology: 18(9);738. guidelines and protocols for the Al-Hosani SM, Al-Belooshi SH, Al- management of work in hot ShahSM,NishtarS,MerchantA.(2008). Yamahi AR, Al-Zaabi MR, Barss P, environments. Research Report for Role of diet and physical activity in Grivna M. (2008). What are the real the Health Authority of Abu Dhabi. patientswithcoronaryarterydisease causes of death in the United Arab 2008. in South Asian population: a case Emirates? Fifth Scientific controlstudy.AnnalsofEpidemiology: Conference for Medical Students in Grivna M, Barss P, El-Sadig M. 18(9);720-721. the GCC Countries, Bahrain, (2008). Epidemiology and January 2008. prevention of child injuries in the Shah SM, Whiting S, Vatanparast United Arab Emirates: A Report for H. (2008). Self-reported Alkaabi J, Al-Maskari F, Saadi H, SafeKids Worldwide. Faculty of hypertension among Canadians: Afandi B, Parker H. (2008). Medicine & Health Sciences and disparity across gender. The Assessment of physical activity Roadway Transportation & Traffic Canadian Journal of Cardiology;24 and dietary practices among Safety Research Centre, Al Ain. (Supplement E) 318E. diabetic patients among diabetic 2008:1-44. patients. 13th Annual Workshop Trakoli A, Aw TC. (2008). on Diabetes Mellitus - Diabetes Occupational blood-borne Mellitus and its Complications”. infections. In: Occupational Health k Faculty of Medicine & Health for Health Care Professionals, 1st Sciences, UAE University, Al Ain, edition (eds. Jayakumar G & UAE. Retneswari M). Malaysian Medical

21 Department of Community Medicine

Alkaabi J, Al-Maskari F, Saadi H, mate selection among University Barss P, Grivna M, Subait O, Al- Afandi B, Parker H. (2008). students in the United Arab Kuwaiti A, Al-Kuwaiti M, Al- Assessment of physical activity Emirates. Proceedings from the Rahoomi A. (2008). Epidemiology and dietary practices among 9th Annual UAE University of falls in a high-income Middle diabetic patients among diabetic Research Conference, May 2008. Eastern country: An Emergency patients. The 1st International Department Interview Survey. Conference on Advanced Barss P, Grivna M, Ali M, Nasser A, Third Australian and New Zealand Technologies and Treatments for Helal I, Karami A. (2008). Water Falls Prevention Conference, Diabetes (ATTD), Prague, Czech safety and drowning prevention: Melbourne, October, 2008. Republic. High school student survey. The 2nd Asia Pacific Injury Prevention Barss P, Grivna M. (2008). Al-Maskari F, El-Sadig M, Alkaabi J, Conference, Hanoi, Vietnam, 4-6 Traditional and epidemiological Afandi B. (2008). Knowledge, November 2008. concepts of causality and attitude and practices of diabetic preventability of injury, HIV, and patients in Al-Ain Medical District, Barss P, Grivna M, Subait O, Al- chronic disease among Arabs in a UAE. The Endocrine Society; 90th Kuwaiti A, Al-Kuwaiti M, Al- Middle Eastern country. Porto Annual Meeting, San Francisco, US Rahoomi A. (2008). Epidemiology Alegre, Brazil. 18th International Aw TC. (2008). Developments in of falls in a high-income Middle Epidemiologic Association World occupational health in the Middle Eastern country: an Emergency Congress, September 2008. East. 19th Asian Conference on Department interview survey. Occupational Health, Singapore, Third Australian and New Zealand Barss P, Grivna M. Epidemiology 17 to 19 September 2008. Falls Prevention Conference, and Prevention of Drowning in Melbourne, Australia, 12-14 Coastal Cities of a High-Income Aw TC. (2008). Challenges in October 2008. Middle Eastern Country. Asia- producing criteria for diagnosing Pacific Injury Prevention occupational diseases. The 18th Barss P,Grivna M. (2008). Letter to Conference, Hanoi, October 2008. World Congress on Safety and Editor –Trends in childhood injury Health at Work, Seoul, Korea, 29 mortality in a developing country: Bernsen RM. (2008). Characteristics June to 2 July 2008. United Arab Emirates. IENJ 2008 of non-participants in blood doi:10.1016/j.ienj.2008.12.003 testing in a cross-sectional study AwTC. (2008). Occupational health on the association between initiatives in the United Arab Barss P, Grivna M. (2008). childhood immunisations and Emirates. The 18th World Congress Traditional and epidemiological atopic disorders. EAP (European on Safety and Health at Work, concepts of causality and Academy of Pediatrics), Nice, Seoul, Korea, 29 June to 2 July preventability of injury, HIV, and France. 2008. chronic disease among Arabs in a Middle Eastern country. 18th Bernsen RM. (2008). EAACI. AwTC. (2008). Occupational health International Epidemiologic Measles, mumps and rubella workers as part of the community. Association World Congress, Porto (MMR) infections and risk of atopic Ninth International Conference on Alegre, Brazil, 18th International disorders in vaccinated and Chemical and Environmental Epidemiologic Association World unvaccinated children (poster Hazards: Working together, Congress, September 2008. presentation). European Academy Protecting Communities, The of Allergy and Clinical Health Protection Agency, Barss P,Musaab A, Nassar A, Helal Immunology, Barcelona, Spain. Manchester, UK, 20-21 May 2008. I, Karami A, Grivna M. (2008). Epidemiology and prevention of Black T, Shah SM, Lim H, Abony S, Barss P,Al-Hammadi M, Al-Atiq M, drowning in coastal cities of a Busch A, Metcalfe J. (2008). The Al-Awadhi H, Grivna M, Bernsen R. high-income Middle Eastern effect of a transfer, lifting and (2008). Evaluation of a short country. Second Asia-Pacific repositioning (TLR) injury educational intervention on Conference on Injury Prevention, prevention program on knowledge and attitudes of motor Hanoi, Vietnam, November 2008. musculoskeletal disorders in vehicle crashes and safety health care workers. Sixth restraints among high school Barss P, Al Hammadi M, Al Atiq M, International Symposium: Public students in the United Arab Al Awadhi H, Grivna M, Bernsen R. Health and the Agricultural Rural Emirates, 9th World Conference (2008). Evaluation of short Ecosystem. on Injury Prevention and Safety educational sessions to improve Promotion, Méridam Yucatán, knowledge and attitudes towards Blair I. (2008). Public health aspects Mexico, 15-18 March 2008. car safety restraints among grade of anthrax. Exercise Solent 12 students at government Regional Multiagency Conference Barss P,Al-Maskari F, Grivna M, Al- schools in United Arab Emirates. on Bio-terrorism, Southampton, Shehhi K, Al-Shamsi H, Al-Kaabi N, Ninth World Conference on Injury Hampshire, UK, 24 January 2008. Al-Suwaidi A. (2008). Smoking, Prevention and Safety Promotion, other high-risk behaviours, and Merida, Mexico, March 2008. Blair I. (2008). Public health

22 Department of Community Medicine response to avian influenza. population. AIDS 2008 - XVII Al Ain, United Arab Emirates. XVIII “Exercise Chicken Run” Regional International AIDS Conference, World Congress on Safety and Health Services Conference on Mexico City, 3-8 August 2008. Health at Work & 24th Asia Pacific Avian Influenza, Southampton, Safety and Health Organisation Hampshire, UK, 13 February 2008. Nagelkerke N, de Vlas S, Jha P , Luo Annual Conference, Seoul, Korea, Blair I. (2008). Environmental M , Plummer F , Kaul R. (2008). 29 June to 2 July 2008. health and health protection Heterogeneity in HIV host partnerships. Hampshire susceptibility as a potential Schneider J. (2008). Assessing heat Environmental Health Officers’ contributor to recent HIV stress during summer in UAE Meeting, Eastleigh, Hampshire, UK, prevalence declines. AIDS 2008 - construction workers. 24th Asia 16 January 2008. XVII International AIDS Pacific Safety and Health Conference, Mexico City, 3-8 Organisation Annual Conference, Blair I. (2008). Pandemic Influenza. August 2008. Seoul, Korea, 29 June 2008. “Exercise Eclipse” Multiagency Conference, Southampton, Nagelkerke N, Moses S , de Vlas S, Schneider J. (2008). Assessing heat Hampshire, UK, 18 January 2008. Bailey R. (2008). Modelling the stress in United Arab Emirates public health impact of male construction workers during El-Sadig M. (2008). The socio- circumcision for HIV prevention in summer. Combined Meeting of economic and environmental high prevalence areas. AIDS 2008 The Australasian Faculty of determinants of MVC injuries and - XVII International AIDS Rehabilitation Medicine & deaths among vulnerable road Conference Mexico City, 3-8 Australasian Faculty of users in Al-Ain, UAE. WHO-EMRO August 2008. Occupational and Environmental Seminar, Center for Social Studies Medicine, Adelaide, South (SRC) of the American University in Nagelkerke, N. (2008). Australia, 8 May 2008. Cairo and the IUSSP, Cairo, Egypt, Heterogeneity in host HIV 14 to 18 February 2008. susceptibility as a potential Schneider J. (2008). Critical success contributor to recent HIV factors in designing and Grivna M, Barss P, Al-Dhabab A, prevalence declines in Africa. implementing an defective Hanaee A, Al-Kaabi F, Al-Muhairi Tubingen Epidemics Workshop on occupational health Scheme for S. (2008). Babywalkers in the Spatio-temporal and Network your organization. Sixth Annual United Arab Emirates: A survey Modelling of Diseases, Baden- GCC Occupational Health among female high school Württemberg, Germany, 21-25 Conference, Dubai, UAE, 26 June students of prevalence, injuries, October 2008. 2008. and knowledge. 9th World Conference on Injury Prevention Nagelkerke, N. (2008). Modelling Schneider J. (2008). GCC and Safety Promotion, Merida, the public health impact of male Occupational Health Professionals Mexico, March 2008. circumcision for HIV prevention in Website - Dept Community high prevalence areas in Africa. Medicine, UAEU, Grivna M, Barss P, Stanculescu C, XVII International AIDS http://www.fmhs.uaeu.ac.ae/cmd/ Abu-Zidan F. (2008). Epidemiology Conference, Mexico City, 3-8 ohs/. of child and youth traffic injury in August 2008. a high-income Arab country: use of Shah SM, Afridi I, Nowshad G. a trauma registry to identify Nikpartow N, Shah SM, Koehncke (2008). Prevalence and correlates priorities for prevention. Second N, Lim H, Melenchuk J. (2008). of depression among married Asia-Pacific Conference on Injury Work-related ocular injuries in women in high mountain villages Prevention, Hanoi, Vietnam, Saskatchewan: disparity across of North Pakistan. The World November 2008. industry sectors. Sixth Psychiatric Association Section of International Symposium: Public Epidemiology and Public Health Hyder GM, Shah SM, Alvi R, Hussain Health and the Agricultural Rural Meeting “From Epidemiology A. (2008). Patterns of injuries in Ecosystem, Saskatoon, Canada, 19 Toward Mental Health Planning”, high mountain villages of to 23 October 2008. Saskatoon, Saskatchewan, Canada, Northern, Pakistan; a community- May 2008. based study. 12th National Health O’ Carroll R, Ulmer B, Shah SM, Sciences Research Symposium, Hundseth M. (2008). Role of above Shah SM, Hussain A, Midtry R, Injury in the Developing World: knee amputation as initial Walraven G, Nishtar N, Jafar T, from Prevention to Care, Karachi, treatment for ischemic lower Reeder B. (2008). Pakistan and Pakistan, 26 to 28 August 2008. extremity. The Canadian Society Canadian Teamwork (PACT) for for Vascular Surgery 2008 Annual CVD prevention: the way forward. Moses S, Ramesh B , Isac S, Meeting, Saskatoon, Canada, 12 15th Canadian Conference on Nagelkerke N, Bhattacharjee P. to 13 September 2008. International Health, Ottawa, (2008). Impact of an intensive, Canada. targeted HIV prevention program Schneider J. (2008). A survey of on HIV prevalence in the general upper limb injuries in carpenters in Shah SM, Koehncke N, Melenchuk

23 Department of Community Medicine

J, Lim H, Gordon JR, Dosman J. Dhabi (HAAD). (2008). Caring for care givers: Drs J Schneider (PI), G Bates. burden of work-related Development, and scientific musculoskeletal disorder in health validation for Gulf conditions, of care, Sixth International guidelines and protocols for the Symposium: Public Health and the management of work in hot Agricultural Rural Ecosystem, environments. Health Authority of Saskatoon, Canada. Abu Dhabi (HAAD).

Shah SM, Melenchuk J, Koehncke Drs M Grivna (PI), P Barss, M El- N, Lim H, Gordon JR, Dosman J. Sadig. (2008). Work-related The magnitude and risk factors of musculoskeletal disorders in childhood injuries in UAE. A agriculture in Saskatchewan, 1996- project funded by 2005. Sixth International Johnson&Johnson Middle East and Symposium: Public Health and the Safe Kids Worldwide through the Agricultural Rural Ecosystem, Scientific Research Affairs Sector of Saskatoon, Canada. the UAE University. (2007-2008).

Shah SM. (2008). Tobacco use Dr I Blair (PI). among women in rural Pakistan: Understanding S. aureus carriage trends between 1994 and 2007. in the community. United The 39th Union World Conference Kingdom Health Protection on Lung Health of the Agency, London. Local and International Union Against Regional Services Division R&D Tuberculosis and Lung Disease, Pump-Priming & Small Initiatives “Global threats to lung health: the Fund – 2007/08. importance of health system responses”,Paris, France. k k

Research Grants

FMHS Seed Money Grant

Profs TC Aw [PI], M McClean, Dr S Shaban. Comparison of preventive medicine curriculum in GCC medical schools.

UAEU Individual Grants

Drs SM Shah [PI], F Al-Maskari. Parents assisting children and teachers (PACT) for obesity prevention. (2008-2009).

Others Prof TC Aw [PI], Drs F Al-Maskari, J Schneider, M El-Sadig. Developing a National Strategy for Environment and Health in the UAE.

Prof TC Aw [PI], Drs Z Taimur, M Zaidi. Determining occupational health priorities for Abu Dhabi and the UAE. Health Authority of Abu

24 Department of Community Medicine

Standing left to right: Mr Hussein El Agab, Dr Michal Grivna, Dr Peter Barss, Dr Mohamed El Sadig, Prof Nico Nagelkerke, Dr John Schneider and Mr Jamal. Seattedlefttoright: Dr Roos Bernsen, Prof Tar-Ching Aw (Chair),Dr Fatma Al Maskari and Ms Arlene Kaljee. Community2008 Medicine

http://www.fmhs.uaeu.ac.ae/cmd/ Tel: 7672000 / Fax: 7672022

25 Department of Family Medicine

Research Profile

Professor & Chair: The Department of Family Medicine is fortunate Prof L Nasir to be able to draw on the talents of a diverse, Associate Professor: Dr C Ellis energetic and talented pool of faculty and staff for Dr C Leduc its teaching, service and research activities. The Dr S Major mission statement of our department integrates Dr A Prinsloo Dr B Raasch the discovery and propagation of knowledge Assistant Professor: important to clinical practice, education, and the Dr DM Mirza organization of health care as a core task. In Dr MJ Hashim Medical Secretary: addition, our leadership roles in medical education Ms MCT Cetra and teaching clinical skills complement the Medical Research provision of an outstanding clerkship experience Technician: Ms H Mustafa to medical students. We also play a leading role Mr J Cherian in supporting medical student community outreach efforts, and support for the community based Family Medicine Residency program.

The Department is also involved in service to the profession, including continuing medical education and licensing activities. Over the coming months and years, we hope to continue to expand our capabilities and activities. Faculty research interests encompass diverse topics that include child health and predictors of obesity, medical education, communication, primary care psychiatry, chronic disease management, informatics, professionalism and health literacy. Department of Family Medicine

Anxiety and Somatoform Nasir L. (2008). Depression, self Articles in Peer- Disorders in the Arab world. In: harm behavior and suicide. In: reviewed Journals Nasir L, Abdul Haq A. (eds). Caring Nasir L, Abdul Haq A,(eds). Caring for Arab Patients; A for Arab Patients; A Biopsychosocial Approach. Oxford: Biopsychosocial Approach. Oxford: Al-Qutob R, Nasir L. (2008). Radcliffe 2008. Radcliffe 2008. Provider Perceptions of Reproductive Health Service Nasir LS, Abdul-haq AK, (Eds) Quality in Jordanian Public (2008) Caring for Arab Patients; a Community Health Centers. Health k biopsychosocial approach. 1st Care for Women International, Edition. Radcliffe Publishing Ltd. Volume 29; 5: 539-550. February 2008. Elie AA, Maroun N, Major S, Afif C, Published Nasir L. (2008). Dysmenorrhea. In: Abdo A, et al. (2008). Post- Abstracts, Conn’s CurrentTherapy 60th (2008) graduation migration intentions Edition. Eds: Rakel,RE Bope, ET. of students of Lebanese medical letters and Saunders/Elsevier schools: a survey study. BMC Public Correspondence Health, 8:191doi:10.1186/1471- Nasir L. (2008). Globalization, 2458-8-19. Health and Culture. In: Nasir L, Mirza DM (2008).The Language of Abdul Haq A (eds). Caring for Arab Instruction (letter to the editor). Heath RL, Saliba M, Mahmassani Patients; A Biopsychosocial Medical Education. Published O, Major SC, Khoury BA. (2008). Approach. Oxford: Radcliffe 2008. Online: Dec 17 2008. Locus of control moderates the relationship between headache Nasir L, Al-Qutob R. (2008). Gender and depression. J Headache Pain, and Health. In: Nasir L, Abdul Haq 9 (5):301-308. k A. (eds). Caring for Arab Patients; A Major SC, Booton C. (2008). Biopsychosocial Approach. Oxford: Involvement of general practice Radcliffe 2008. Proceedings, (family medicine) in undergraduate medical education Conferences, Nasir L. (2008). Death and Dying. in the United Kingdom. J Ambul In: Nasir L, Abdul Haq A, (eds). Invited lectures, Care Manage, 31(3):269-75. CaringforArabPatients;A Web Sites and Biopsychosocial Approach. Oxford: k Radcliffe 2008. Others Nasir L, Abdul-Haq A. (2008). Mirza DM. (2008). Using a Western Approach to the patient in primary Curriculum in the Middle East- Books, Chapters, care psychiatry. what are the implications for In: Nasir L, AbdulHaq A.(eds). clinical skills teaching? Asia-Pacific Reviews and CaringforArabPatients;A Medical Education conference in Editorials Biopsychosocial Approach. Oxford: Singapore, January 2008. Radcliffe, 2008. Hamdy,S. Nasir,L. (2008). Culture and Health. In: Nasir,L. Abdul-Haq Nasir,L. (2008). Substance Abuse. k A. (eds) Caring for Arab Patients: A In: Nasir L, Abdul Haq A. (eds). Biopsychosocial Approach. Oxford: CaringforArabPatients;A Radcliffe 2008. Biopsychosocial Approach. Oxford: Radcliffe 2008. Khoury B, Khoury M, Nasir L. (2008).

Family Medicine http://www.fmhs.uaeu.ac.ae/Departments/Family Medicine 2008Tel: 7672000 / Fax: 7672022

27 Department of Internal Medicine

Departmental Profile

Professor & Chair: This Department has been highly active in the three fields of Prof M Ellis Teaching, Research and Clinical Duties through 2008. Professor: Prof E N Obineche The following is a list of continuing education activities Prof I Galadari organised by departmental members in 2008: Prof E E Kazzam Prof S Gariballa Prof A Bellou -Coordinator, 13th Annual Workshop on Diabetes Mellitus. Associate Professor: Activity organized by the Al Ain Diabetes Research Group; March Dr W Conca 22, 2008, Faculty of Medicine and Health Sciences, Al Ain, UAE. Dr I Hassan (Dr H Saadi) Dr H Saadi Dr J Braun -Member, Scientific Committee for The Fourth Pan Arab Dr S Denic Osteoporosis Conference; March 3, 2008; Dubai, UAE. (Dr H Dr J Alkaabi Saadi) Dr S Al-Suwaidi Assistant Professor: -Stroke CME. May 10, 2008. Al Ain Hospital, Al Ain, UAE. (Dr J Dr A Shehab Braun) Dr A Al-Fazari Dr H Galadari Teaching Assistant: Dr A Shehab organised the following 10 approved CME’s Dr A Al-Dhanhani (32 approved credit hours) in cardiology including Dr S Al-Karam hypertension, heart failure and myocardial infarction: Dr G Al Mansouri Dr M Al Houqani -Endocrine Medicine Rapid Review Course. 6 hours CME HAAD. Medical Research Saturday, December 27, 2008. Venue: Rotana Hotel, Al Ain, UAE. SpecialistI Dr S Benedict -Acute coronary syndrome in UAE. 2 hours CME HAAD. Friday, Dr A M Abdulle March 7, 2008. Venue: Rotana Hotel, Al Ain, UAE. Mr J Yasin Research Nurse Mr A Alessa -Hypertension update. 4 hours CME HAAD. Friday, May 9, 2008. Research Assistant Venue: Hilton Hotel, Al Ain, UAE. Ms M Kutty Ms S Al Marar -Lipids update. 2 hour CME HAAD. Friday, June 27, 2008. Venue: Administrative Assistant Jabal Hafeet Hotel, Al Ain, UAE. Mr H Hassan Medical Secretary: -Complications post MI and practical approach. 2 hour CME Ms S Ogilvie HAAD. Wednesday, November 26, 2008. Venue: Intercontinental Ms R John Hotel, Al Ain, UAE. Secretary -Heart failure. 2 hour CME HAAD. Friday, January 25, 2008. Department of Internal Medicine

Venue: Rotana Hotel, Al Ain, UAE. Dr S Benedict (Medical Research Specialist I), Dr A M Abdulle (Medical Research Specialist II) -ECG course and workshop. 6 hour CME HAAD. and Mr J Yasin (Medical Research Specialist II) Saturday, April 5, 2008. Venue: Rotana Hotel, Al have been enmeshed in the research activities Ain, UAE. of various faculty within and outside the Department. Their workload increases steadily -Valve replacement update. 2 hour CME. with time. Mr Awad Al-Essa (Research Nurse), is Tuesday, December 16, 2008. Venue: Rotana busily occupied with several research projects. Hotel, UAE. Ms Mary Kutty (Research Assistant) has been funded by an external grant. -Emirates Cardiac Society Intercity Meeting 25 - 26 April, Venue: Hilton Hotel, RAK, UAE. Ms Shaikha Al-Marar (Research Assistant) is actively involved with faculty research projects. -Hypertension update. 4 hour CME HAAD. Friday, December 19, 2008. Venue: Hotel JAL, Ms Sheena Ogilvie and Ms Reena John continue Fujairah, UAE. to provide secretarial services and Mr Hisham Hassan vital administrative services for the The MRCP(UK) PACES Centre at Al Ain Hospital Department. is firmly established and is providing 2 diets per year. Four examiners have been approved The Departmental laboratory is located on from the Department: Professor M Ellis, the 3rd floor and research interests and Professor S Gariballa, Professor E N Obineche and publications covered in 2008 were: Dr A Shehab. Professor E N Obineche also examines in the Arab Boards Internal Medicine.

A Professorial Medical Unit (PMU) has been GENETICS VASOACTIVE PEPTIDES established at Al Ain Hospital under the Clinical DERMATOLOGY DIABETES Directorship of Professor S Gariballa. This clinical CYTOKINES HYPERTENSION unit will provide resources for clinical care, postgraduate residency teaching and clinical CANCER OSTEOPOROSIS research. INFECTIONS, INCLUDING FUNGI CARDIOVASCULAR DISEASE LIPIDS CHRONIC RENAL FAILURE In relation to Teaching Assistants, we have PLEURAL DISORDERS RHEUMATIC DISEASE five who are studying abroad. They are as follows:

-Dr A Al-Dhanhani /Teaching Assistant (Canada) -Dr S Al-Karam/Teaching Assistant (Canada) The Department members published 24 papers -Dr G Al Mansoori/Teaching Assistant (Canada) in peer-reviewed journals, 3 book chapters, -Dr M Al Houqani/Teaching Assistant (Canada) reviews or editorials, 9 abstracts and 46 -Dr S Al-Shamsi/Teaching Assistant (Canada) conference presentations and 7 clinical grants are held.

29 Department of Internal Medicine

Sciences 1; 18-21. MPT, Sulaiman M, Al-Rokhaimi M. Articles in (2008). Leptin, lipid and lipid Peer-reviewed Bukachi F,Waldenström A, Morner metabolism-related hormones in S, Lindqvist P,Henein MY, Kazzam chronic renal failure in Arabia. Journals E. (2008). Age dependency in the Nephrology (Online) 7(3); 115-120. timing of mitral annular motion in Abdulle AM, Nagelkerke NJ, relation to ventricular filling in Obineche EN, Saadi H, Benedict S, Abouchakra S, Obineche EN. healthy subjects. Umeå General Pathan JY, Frampton CM, Nicholls (2008). Potential benefits of Population Heart Study. Eur J MG. (2008). Inter-relationships controlling coronary heart disease Echocardiogr 9(4); 522-529. between B-type natriuretic risk factors in the United Arab peptides and vitamin D in patients Emirates. Kidney & Blood Pressure Denic S, Nagelkerke N, Agarwal on maintenance peritoneal dialysis. Research 31(3); 185-188. MM. (2008). Consanguineous Perit Dial Int 28(6); 617-621. marriages and endemic malaria: Abdulle AM, Nagelkerke N,Yasin J, can inbreeding increase Raza H, John A, Brown E, Benedict Obineche E. (2008). Biochemical population fitness? Malaria S, Kambal A. (2008). Alterations in markers and lipid profiles in a Journal 7;150. mitochondrial respiratory multiethnic hypertensive functions, redox metabolism, and population from the United Arab Denic S, Nagelkerke N, Agarwal apoptosis by oxidant 4- Emirates. Journal of Nephrology MM. (2008). Consanguineous hydroxynonenal, and antioxidants and Renal Transplantation (JNRT) marriages: do genetic benefits curcumin and melatonin in PC12 1(1); 23-31. outweigh its costs in populations cells. Toxicol Applied Pharmacol with alpha+-thalassemia, 15; 226(2):161-168. Al-Kaabi J, Al-Maskari F, Saadi H, hemoglobin S, and malaria? Afandi B, Parkar H, Nagelkerke N. Evolution and Human Behavior Saadi H, Nagelkerke N, Carruthers (2008). Assessment of dietary 29(5); 364-369. SG, Benedict S, Abdulkhalek S, practice among diabetic patients Reed R, Lukic M, Nicholls MG. in the United Arab Emirates. Rev Ellis M, Ramadi B, Finkelman M, (2008). Association of TCF7L2 Diabet Stud 5(2); 110-115. Hedstrom U, Kristensen J, Ali- polymorphism with diabetes Zadeh H, Klingspor L. (2008). mellitus, metabolic syndrome, and Al-Maskari FN, Obineche E, El- Assessment of the clinical utility markers of beta cell function and Sadig MA. (2008). Prevalence and of serial ‚-D-glucan concentrations insulin resistance in a population- determinants of microalbuminuria in patients with persistent based sample of Emirati subjects. among diabetic patients in the neutropenic fever. J Med Microbiol Diabetes Research and Clinical United Arab Emirates. BMC 57; 287-295. Practice 80(3); 392-398. Nephrol 9; 1. Gariballa SE, Forster SJ. (2008). Sajwani S, El Houni A, Gariballa S. Awad MA, Denic S, ElTaji H. (2008). Dietary intake of older patients in (2008). Not just a case of Validation of the European hospital and at home: the validity thyrotoxicosis. Emirate Medical Organization for research and of patient kept food diaries. J Nutr Journal 26(2); 129-130. treatment of cancer quality of life Health Aging 12(2); 102-106. questionnaires for Arabic-speaking Shehab A, Elnour AA, Sadiq A, populations. Annals of New York Gariballa S. (2008). Refeeding Ellahham NH. (2008). Monitoring Academy of Sciences 1138;146-54. syndrome: a potentially fatal the doctors’prescribing patterns in condition but remains outpatient polyclinic setting. Barnes S, Gott M, Payne S, Parker C, underdiagnosed and Khartoum Pharmacy Journal 11(1); Seamark D, Gariballa S, Small N. undertreated. Nutrition 24(6); 604- 6-11. (2008). Predicting mortality among 606. Epub 2008 Mar 24. a general practice-based sample of Shehab A, Elnour AA, Struthers A. people with heart failure. Chronic Gariballa SE. (2008). Homocysteine (2008). Randomised controlled Illn 4(1); 5-12. and Stroke. Current Topics in double-blind cross over pilot study Naturaceutical Research; 6 (4): 211- assessing the effect of Braun JS, Bauknecht H-C. (2008). 218. Spironolactone, Losartan and their Cancer and incontinence. The combination on heart rate Lancet 372; 1272. Mörner S, Lindqvist P,Waldenström variability (HRV) and QT dispersion A, Kazzam E. (2008). Right in patients with chronic heart Braun JS, Herzog KH. (2008). E2F1 ventricular dysfunction in failure (CHF). Cardiovascular mediated pneumococcal-induced hypertrophic cardiomyopathy as Journal of South Africa 19(6); 302- brain damage. Acta evidenced by the myocardial 306. Neuropathologica 116; 133-134. performance index. J Cardiol 124(1); 57-63. Braun JS. (2008). Cryptococcal k meningitis. Journal of Medical Obineche EN, Abdulle AM, Gillett

30 Department of Internal Medicine

population from the United Arab Alkaabi JM. (2008). Knowledge, Books, Chapters, Emirates. American Journal of attitude and practices of diabetic Reviews and Kidney Diseases 51(4); B75-B75. Patients in Al-Ain City, United Arab Emirates.The 90th annual meeting Editorials Obineche EN, Saadi H, Benedict of the Endocrine Society. San S, Pathan J, Frampton C, Nicholls Francisco, USA. Ellis M. (2008). Human avian M. (2008). Inter-relations between influenza infection. In ‘Clinical B-type natriuretic peptides & Vit D Al Wedami M, Al Emadi B, Bakathir Medicine’. Online Chapter. Editors in patients on maintenance S, Al Abdouli F, AlYammahi AM, Al Kumar and Clark M. 7th edition. peritoneal dialysis & in women Medhani T, Al Yammahi AA, Al Elsevier Saunders. post-partum. American Journal Abdouli A, Al Yamahi S, Al Anee K, of Kidney Diseases 51(4); A75. Shah G, Kazzam E. (2008). Heart Ellis M. (2008). New dosing Failure: Etiology, Risk factors and strategies for liposomal Saadi H, Nagelkerke N. (2008). Management in Al Ain Hospital, amphotericin B in high-risk Correlation coefficients are not World Heart Failure Congress, patients. Clin Microbiol Infect appropriate for assessing February 2008, Al Ain, UAE. 14(S); 55-64. differences among populations. Letter to the Editor. J Clin Braun JS. (2008). TLR-2 mediates Ellis ME. (2008). Febrile Endocrinol Metab. CSF inflammation and neuronal neutropenia: evolving strategies. damage. 3rd Al Ain International Ann NY Acad Sci 2 1138; 329-350. Saadi H, Afandi B, Houssami L, Immunology Meeting. Al Ain, UAE. Saleh N, Mohamadiyeh M, Benedict S. (2008). Effects of Braun JS. (2008). Stroke k isotretinoin on bone turnover Conference. Sanofi Aventis Video markers and bone mineral density Conference, Al Ain Hospital, in women with acne vulgaris and Tawam Hospital and Sheikh Khalifa Published, vitamin D deficiency. Osteoporosis Medical City, UAE. International 19(2). Abstracts, Conca W. (2008). Pathogenesis, letters and diagnosis and management of SLE. k 3rd Al Ain International Correspondence Immunology Meeting. Al Ain, UAE.

Al-Sarraj T, Saadi H, Volek JS, Denic S. (2008). Selection of a+- Fernandez ML. (2008). Prevalence Proceedings, thalassemia in inbreeding of the metabolic syndrome in the Conferences. population. 2nd Genetics United Arab Emirates. The FASEB Conference. Al Ain, UAE. Journal. 2008;22:1083.10 Invited lectures, Web Sites and Denic S, Saad S, Takala M. (2008). Carruthers G, Saadi H. (2008). Re: Prevalence of neutropenia in Continuity of Care Literature Others Arabs. 19th International Congress review and Implications. Letter to on Anti Cancer Treatment. Paris, the Editor. Sultan Qaboos Al Abdouli F, Al Yammahi AM, Al France. University Medical Journal 8(2). Medhani T, Al Yammahi AA, Al Abdouli A, Al Yammahi S, Al Ellis M. (2008). TB: Clinical Denic S, Nagelkerke N, Nicholls Wedami M, Al Emadi B, Bakathir S, orientation and UAE focus. Clinical MG. (2008). Germline genomic Al-Anee K, Shah G, Kazzam E. workshop on TB. 3rd Al Ain homozygosity and cancer risk. (2008). Pattern of Cardiovascular International Immunology Journal of American Medical Diseases in Al Ain City. World Heart Meeting. Al Ain, UAE. Association 300(2); 169-70. Failure Congress, Frbruary 2008, Al-Ain, UAE. Gariballa S. (2008). Effects of Henein M, Calcuttea A, Kaba A, smoking on nutritional status and Maras D, Stanton M, Kelly M, Alkaabi J, AlMaskari F, Saadi H, response to dietary supplements. Kazzam ES, Waldenstrom A, Afandi B, Parker H. (2008). British Nutrition Society Meeting. Henein MY. (2008). Atrial Assessment of physical activity Nottingham, UK. fibrillation (mechanistic view and dietary practices among point). Int J Cardiol. diabetic patients. First Gariballa S. (2008). Nutritional and International Conference on quality of life in older people. Obineche E, Pathan J, Obineche R, Advanced Technologies and International Conference for Abdulle A. (2008). Biochemical Treatments for Diabetes (ATTD). Aging. Abu Dhabi, UAE. markers and lipid profiles in a Prague, Czech Republic. multiethnic hypertensive Gariballa S. (2008). Effects of acute phase response on nutritional

31 Department of Internal Medicine

status and clinical outcome of Meeting of the Egyptian Society Prof S Gariballa [PI]. The effects of hospitalised patients. The 3rd Al for joint diseases and arthritis. dietary supplements on Ain International Immunology Sharm Al Sheikh, Egypt. cardiovascular disease risk factors Conference. Al Ain, UAE. and infections of subjects with Saadi H. (2008). Diabetes and type 2 diabetes mellitus. Gariballa S. (2008). Public health hypertension. Harvard CME nutrition: Prevention and Symposium on “Recent advances treatment of disease. Al Ain in cardiometabolic risk Dr A Shehab [PI]. Improving Paramedical Professional management”. Cairo, Egypt. medication Development Conference. Al Ain, adherence/compliance and UAE. Saadi H. (2008). Osteoporosis and concordance in family practice vitamin D deficiency in Arab clinics: The leadership perspective. Gariballa S. (2008).The fetal origins Women. The fourth Pan Arab of adult disease hypothesis. Osteoporosis Conference. Dubai, Update on Nutrition. Dubai, UAE. UAE. HAMDAN AWARD MEDICAL Gariballa S. (2008). Associations Saadi H, Nagelkerke N. (2008). RESEARCH GRANT between smoking, nutritional Association of TCF7L2 status and clinical outcome polymorphism with diabetes Prof EN Obineche [PI]. Hamdan following acute illness. mellitus, metabolic syndrome, and Award to Support Medical Proceedings of the Nutrition markers of beta cell function and Research (Achievement Award). Society 67; OCEE8. insulin resistance in a population- 25 March 2008. based sample of Emirati subjects. Gariballa S. (2008). Prevalence of Commentary. The International OTHERS (including international folate deficiency and Atherosclerosis Society (IAS); funding agencies) hyperhomocystinemia in http://www.athero.org; May 2008. hospitalized acutely ill patients at Prof M Ellis [PI]. A study of Al Ain. International Students Shehab A. (2008). Aspirin status bacteremia in cancer patients. Conference. Bahrain. for primary and secondary Wyeth unrestricted grant. prevention. 24th Oman heart Kazzam E. (2008). Heart failure in association annual conference. Dr H Saadi [PI]. High prevalence of the Middle East; Right Ventricular Oman. rickets and sub-clinical maternal Failure; Diabetes Mellitus and and childhood vitamin D Heart Failure. World Heart Failure, Shehab A.. (2008). Acute coronary deficiency in the Middle East: a Al Ain, UAE. syndrome practical approach. 2nd randomized controlled trial of Fujaira Cardiovascular Symposium. prenatal vitamin D Kazzam E. (2008). Left atrial Fujaira, UAE. supplementation to prevent aneurysm an unusual location and vitamin D deficiency in mothers detection using tran-thoracic Shehab A. (2008). Multimodality and their infants. Co-Principle echocardiograpjy: Case imaging in cardiology. 3rd Investigator. Funded by the presentation. 24th Annual International Congress of Thrasher Research Fund (USA) International Conference on Cardiology and Cardiovascular (2008-2011). Recent Advances in Imaging. Echocardiograpy. Dr H Saadi, Co-investigator. Shehab A. (2008). Stent Release of rectal hormones for Obineche EN. (2008). The cardio- thrombosis. 2nd live weight loss and improvement of renal syndrome - Nephrologists demonstration course in Basic and type 2 diabetes mellitus; Satiogen, viewpoint. World Heart Failure Advanced Interventional San Diego, CA, USA Congress (World Heart Failure Cardiology. Society). Al Ain, UAE. k Saadi H. (2008). Glycemic target: is k lower better? Cardiometabolic risks CMR phase II program. Organized by the Egyptian Diabetes Center in collaboration Research Grants with the American Diabetes Association. Muscat, Oman. FMHS RESEARCH GRANT

Saadi H. (2008). Osteoporosis: A Drs S Denic [PI], S Saad, M Takala. debilitating disease that can be Prevalence of neutropenia in adult prevented and treated. Satellite Arabs from United Arab Emirates. symposium at the 30th Annual

32 Department of Internal Medicine

Standing left to right: Ms S Ogilvie, Mr Abubaker, Mr J Yasin, Mr H Hassan, Dr H Saadi, Dr A M Abdulle, Mr A Al-Essa, Dr S Denic, Professor E Kazzam, Dr S Benedict, Ms R John, Dr I Hassan Seatted left to right: Dr A Al Fazari, Dr J Braun, ProfessorSGCarruthers, Professor E N Obineche, Professor M Ellis, 2008InternalDr S Alsowaidi, Dr W Conca, Dr J Alkaabi Medicine

http://www.fmhs.uaeu.ac.ae/Departments/Internal Medicine Tel: 7672000 / Fax: 7672995

33 Department of Medical Education

Research Profile

Acting Chair: The main research activities of the Department of Dr Beverly Raasch Professor: Medical Education can be found in the MERGE Prof Michelle McLean (Medical Education Research Group) report. Assistant Professor: Dr Sami Shaban Research that has been completed or is in progress Medical Communication in the Department includes: and Study Skills Lecturer: Ms Geraldine Kershaw Mr David Christie Administrative Assistant: Mr CP Nair • Development of transferable/generic skills in undergraduate Mr Mohammad Nazimuddin medical students (McLean, Shaban). Incoming MSC1 students are Ms N Seifelnasr surveyed and followed up in MSC2 to check for skills Secretary: development. The project is in its third year. Results for the first Ms Soni Lal two cycles will be available shortly. Office Assistant: Mr T Usman • Perceptions of the practice of medicine for FMHS male and MEDIA CENTER female students and graduates (McLean). This project began in AV Specialist: 2007 when most final year medical students were interviewed. Mr Musa Yassin Follow-up of these students into their internship has begun. Graphic Designer: Ms Ivanna Lizarriturri • Predictors of student success in the FMHS. By looking at a Ms Shaikha Butti number of variables, such as high school grades, interview Photographer: scores, NBME examination results, it may be possible to find Mr Ashok Prasad predictors of academic success (Shaban, McLean). This work is Reprographic Technician: ongoing. Mr Madhatil Aboobacker

SKILLS AND TEACHING • Emirati patients’ physician preference and attitudes towards LABORATORIES students in the clinical encounter.This work commenced in July Laboratory Supervisor: 2008 as a summer project (4 Medical Science students). These Mr Kunnath Unnikrishnan students interviewed female Emirati patients. Two male students Mr Athiq Wahab will continue the study with male Emirati patients. LaboratoryAssistant: Mr Shanmugam Pandian • Faculty and student perceptions of where the CanMEDS Mr Babuhan Abubakkar competencies are being met. A group of Medical Science students LEARNING RESOURCE CENTER undertook this research during the summer and the first semester Medical Resource Specialist: of the 2008/2009 academic year. Mr Ahmad Fathy Ms Widad El Gaili • Mapping medical school curricula (Shaban, McLean). Department of of Medical Education

• Development of a trauma registry (Abu-Zidan, Shaban).

• Development of a residency management website which includes resident personal information, rotations, assessments, evaluations, and a logbook (Shaban, Safi).

Technical support The Department of Medical Education provides technical assistance for research and researchers through the Media Center, an in-house production unit. The Center offers the graphics, photography and audiovisual services. Faculty members and students make use of these services for journal submissions, poster presentations at professional conferences, seminars, workshops and conferences , student research activities and other Faculty reports.

The Graphics section assists faculty and students with the preparation of scientific posters. The 100 or more posters generated each year are electronically archived and accessible to FMHS members. This section also provides support for PowerPoint presentations and image editing on a daily basis, as well as producing artwork, leaflets and brochures to support student and staff professional activities.

During 2008 academic year, the Audio-Visual section in conjunction with the photography section serviced all research related activities organized by the FMHS. A photographic record of these events is published on a regular basis on the FMHS website.The photography section also produces a significant number of laboratory specimen photographs and is responsible for digitizing radiology material for journal publication.

The Audio-Visual section provides complete audio-visual equipment and support for auditoria, theaters, classroom and other units such as surgical skills and teaching laboratories and other activities. Video filming, editing and duplication, video streaming production and audio recording, among others for research presentations are also services provided by this section.

35 Department of Medical Education

McLean M. (2008). Innovations in Articles in Peer- medical education: yesterday, reviewed Journals today and tomorrow. University of Monash, Churchill, Australia. Barss P, Grivna M, Al Maskari F, Kershaw GE. (2008). Strengthening McLean M, Shaban S. (2008). public health medicine training Developing generic skills in medical for medical students: development students: How do we do this? and evaluation of a lifestyle International Medical Education curriculum. Medical Teacher 30: Conference, Kuala Lumpur. e196 – e218. McLean M. (2008). Trends in McLean M, Cilliers FJ, van Wyk JM. Medical Education: Past, Present (2008). AMEE Guide 36. Faculty and Future. First Saudi development, yesterday, today International Conference on and tomorrow. Medical Teacher Medical Education, Riyadh, Saudi 30: 555-584. Arabia.

McLean M. (2008). Student role in k curriculum development. First Saudi International Conference on Medical Education, Riyadh, Saudi Arabia.

Proceedings, McLean M, Higgins-Opitz SB, van Conferences. Wyk JM, Moodley K, Soornarain S. (2008). Male and female Invited lectures, students and graduates Web Sites and perceptions of the practice of medicine. AMEE Conference, Others Prague, Czech Republic.

Kershaw GE. (2008). Why do Shaban S, McLean M. (2008). students plagiarise?TESOL Arabia Predictors of medical school 14th Annual Conference Dubai, performance. Annual UAEU UAE. Research Day, April 2008.

McLean M, Al Fazari A. (2008). Shaban S, Torab F. (2008). Trainee Preparing consultants for Opinions on LaparoscopyTraining supervising and assessing in clinical using the LapSim Virtual Reality teaching units in Internal Medicine. Simulator versus the Traditional 13th Ozzawa Conference, Box Trainer. Proceedings of the Melbourne, 5-8 March 2008. American Medical Informatics Association 2008 Annual McLean M, Al Kaabi J. (2008). Symposium. Washington DC, USA, Improving internal medicine Nov 2008. residents’success for international board examinations: use of a ‘mock’examination. 13th Ozzawa k Conference, Melbourne, 5-8 March 2008. Poster presentation.

36 Department of Medical Education

Standing left to right: Mr A Wahab, Mr K Unnikrishnan, Mr M Nazimuddin, Mr M Aboobacker, Dr Sami Shaban, Mr CP Nair, Mr K Pandian, Mr M Yassin, Mr B Abubakkar, Mr T Usman, Mr A Prasad Seatted left to right: Ms Nasa Seifelnasr, Ms Ivanna Lizarriturri, Prof Michelle Mc Lean, 2008DrMedical Beverly Rasch, Ms G Kershaw, Ms Education S Lal

http://www.fmhs.uaeu.ac.ae/Departments/Medical Education Tel: 7672000 / Fax: 76723167

37 Department of Medical Microbiology & Immunology

Research Profile

Professor & Chair : Department of Medical Microbiology and Prof M L Lukic Immunology was understaffed and the arrival of Professor: Prof S Dissanayake Professor Tibor Pal, Drs Gulfaraz Khan and Agnes Prof T Pal Maria Sonnevend significantly enhanced research Prof BK al-Ramadi activities and postgraduate teaching and Prof T A Rizvi Associate Professor: supervision. The department at present has six Dr G Khan graduate students working in departmental Assistant Professor: research laboratories. Development of National Dr Ahmed Al Qahtani Dr M al-Shamsi researchers and faculty remain one of the main Dr Agnes Sonnevend focuses of the department. Dr Qahtani is in his Medical Research final stage of his postdoctoral training at the Specialist: Ms Akela Al Ghazawi University of California which has also resulted in Mr A Al-Haj a publication in the prestigious journal Nature Mr H S El-Hasasna Immunology. Ms M Ibrahim Mr M K Jahabar Mr A Shahin Under the leadership of Professor al-Ramadi, the department was Dr E Zilahi involved in organization of the 3rd Al Ain International Medical Research Immunology Meeting. International exposure of the department Assistant: was enhanced by publications in major journals (most of them Ms G Bashir published at the beginning of 2009 rather than in 2008), Secretary collaboration with major research universities (University of Ms G K Dawood Cambridge, Harvard Medical School, University of Glasgow, etc) Ms N J S Al-Dhafri and invited editorship of the important journals in our field of Office Assistant: research. MrMHMajeed Research activities and achievements of the departmental laboratories were as follows:

Professor Basel al-Ramadi - A major focus of research in Professor al-Ramadi’s laboratory has been on identifying means by which the innate immune response can be used to boost anti-cancer immunity. They have demonstrated that an attenuated strain of Salmonella typhimurium, which has been genetically engineered to express interleukin-2 (IL-2), was Department of Medical Microbiology & Immunology effective in inhibiting the growth of malignant Professor Senarath Dissanayake -Dr. melanoma.They have also shown that this form Dissanayake’s research interests are in parasite of immunotherapy is active when given orally, glycan immunobiology and tuberculosis. which is of significant benefit as it decreases Current emphasis in glycan immunobiology is the toxicity often associated with systemic on molecular characterization of parasite cytokine therapies.The exact mechanism(s) by glycans with respect to upregulation of the which recombinant Salmonella strains inhibit transcription factor NF-kB and signaling effects tumor growth are not yet fully known. However, and mechanisms leading to IFN-g and IL-6 evidence to date indicates that the process is expression (Figure 2). With respect to IFN-Á, independent of T lymphocytes but is dependent one specific area of research is negative on Toll-like receptors (TLRs), implying a critical regulation ofTLR signaling. Long-term objective role for the innate immune response in the anti- is development of synthetic immunoadjuvants tumor effect. A report describing the with definedTh-1 andTh-2 immunomodulatory experimental model system and findings was properties. Based on the previous finding that published recently in Clinical Immunology terminal ‚-(1-4) galactose residues on GlcNAc 130:89-97, 2009 (Figure 1). backbones is an epitope regulating IFN-Á (aTh- 1 cytokine), a panel of synthetic glycans is being investigated for further development as adjuvants. In tuberculosis research, epidemiological studies are being carried out to determine the source(s) of infection, patterns of transmission and the possible causes of likely re- activation in long-term residents of UAE.

Figure 1: Treatment of B16 melanoma-bearing mice with Figure 2: Taenia crassiceps glycans were precoated on to multiple low doses of IL2-expressing Salmonella 96 well microtitre plates and 2 million mouse spleen cells typhimurium (strain GIDIL2) prolongs host survival and were added to each well. An antibody to mouse TLR2 was inhibits tumor growth. Tumor-bearing mice were given three added (blue line, triangles). At lower concentrations of i.p. injections at the indicated days (arrows) of either saline antibody (minimal cross linking), IFN-Á synthesis was or low doses (103-104 per mouse) of the GIDIL2 strain. Tumor stimulated while at higher concentrations of anti-TLR volume (A) and animal survival (B) were then followed over antibody, IFN-Á synthesis was inhibited. This effect was the next 60 day s. Each data point represents the mean ± more specific to TLR2, compared to TLR4 (violet). SEM of 8–10 mice per group. Asterisks denote statistically Microtitre plate coated Taenia glycans were IFN-Á significant differences from saline control group (***, p < stimulatory over a 100 fold concentration (green) less than 0.001; **, p <0.01). when added in solution (red).

39 Department of Medical Microbiology & Immunology

Professor Miodrag Lukic - The main focus of Professor Lukic was mentor of two graduate Professor Lukic’s laboratory in 2008 was the students in the FMHS Graduate Program. He has analysis of the role of galectin-3 in the induction co-edited with Professor Ramadi a thematic of organ-specificT cell mediated autoimmunity. issue of Clinical Immunology and was Scientific In the two experimental models, low dose Chair of the 2nd EFIS Meeting on streptozotocin inducted diabetes and MOG35- Immunuregulation entitled “Chronic 55 peptide induced experimental allergic Inflammation at the Interface of Innate and encephalomyelitis. They have shown that Gal- Acquired Immunity”. 3-/- mice exhibit significant resistance to the induction of disease (Clinical Immunology Professor Tahir Rizvi - The focus of Professor 130:83-88, 2009). Molecular and cellular analysis Rizvi’s research concerns the basic steps in of this resistance demonstrated that galectin- retroviral replication with the ultimate goal of 3 preferentially limit IL-10 synthesis by dendritic developing improved retroviral vector systems cells which in turn bases the production of IL- for human gene therapy. Specifically Prof. Rizvi’s 17 and IFN-Á and inhibit development of Th-2 laboratory is attempting to unravel how and regulatory cells (J. of Immunology, 182: retroviruses/lentiviruses package their genomic 1167-1173, 2009) (Figure 3). RNAs into a virus particle and what are some of the underlying differences in RNA packaging The other line of research include the dissection among retroviruses/lentiviruses. Over the years, of the role of Th-1 and Th-17 cells and the effect these studies have included a number of of attenuation of Th-2 signaling in induction of retroviruses/lentiviruses including HIV, SIV, FIV, experimental diabetes (Molecular Immunology, and MPMV. These studies have been further in press). expanded to include analyses of cross- and co-

FIGURE 3: Gal-3–/– mice developed less severe EAE than did WT mice. Mice were immunized with MOG35–55 peptide and CFA. A, Clinical scores show that Gal-3–/– mice had a reduced EAE severity. However, all mice in both groups developed EAE (B). Results are mean clinical scores ± SEM (n = 11/group). *, p < 0.05 and **, p < 0.01, representative of four experiments. C, Pathology of spinal cord sections of WT (a and b) and Gal- 3–/– mice (c and d) were examined 18 days after immunization using H&E staining at low (a and c) and high magnification (b and d). WT mice exhibited typical perivascular and subpial infiltrates of different sizes, while Gal-3–/– developed only single cell and rare small subpial mononuclear cell infiltrates. D, Semiquantitative assessment of the histological sections from the spinal cord of WT and Gal-3–/– mice. Ten noncontiguous sections per spinal cord were scored. ***, p < 0.001 (n = 3) - (J. Immunol, 182: 1167, 2009).

40 Department of Medical Microbiology & Immunology packaging among retroviruses/lentiviruses. in this country investigating strains collected Over the years, Prof. Rizvi has been able to from five different hospitals (Figure 4). In successfully compete for and acquire both these studies molecular based typing intramural and extramural grant support for methods, such as various PCR-based his work on retroviruses. Currently Prof. Rizvi techniques and macro-restriction analysis holds a prestigious Wellcome Trust Grant in are being used. The other project aims to collaboration with Professor Andrew Lever reveal the mechanisms of antibiotic of Addenbrooke's Hospital, University of resistance in these strains and the regulation Cambridge, UK. Prof. Rizvi has been very how these genes, mostly beta lactamases of active in supervising and mentoring both the various spectra, are expressed. It is graduate and undergraduate student. His anticipated that the results will aid to design current studies on RNA packaging have been and implement better strategies to control published in journals of international repute. the spread of this emerging pathogen.

Professor Tibor Pal - Since 2008 Professor Dr Gulfaraz Khan joined the department in Pal’s laboratory has been engaged in research November 2008. His main research interest is in on antibiotic resistant Gram negative bacteria oncogenic viruses and viral tumour biology, in causing mostly nosocomial infections. The particular, Epstein-Barr virus (EBV) and its model organism is an opportunistic association with human malignancies of pathogen, Acinetobacter baumannii epithelial and lymphoid origin. The current responsible for an alarmingly increasing projects being pursued in Dr Khan’s laboratory number of urinary tract, blood stream, wound are:

Figure 4: Clonal typing of local isolates (NM90-96) of Acinetobacter baumannnii by a combination of multiplex PCR reactions.

and pulmonary infections with high mortality. (1) The role EBV plays in the pathogenesis of It is a highly clonal organism; the strains breast cancer and Hodgkin lymphoma. causing outbreaks worldwide represent a few (2) The mechanisms by which the two genetic lineages only. The outbreak clones are abundantly expressed non-protein-encoding multidrug resistant, often resistant to drugs, EBV RNA molecules (EBER-1 and EBER-2) inhibit such as carbepenems, also apoptosis and promote cell transformation. We considered as last reserves for serious Gram have developed a highly plausible model which negative infections. In one of our projects we are currently testing (Figure 5). we study the clonal distribution of the isolates

41 Department of Medical Microbiology & Immunology

Figure 5: Proposed model for the regulation of apoptosis by the EBERs and PKR. EBV infection results in two important phenomena (amongst many others), viz. high level expression of EBERs -1 and -2 and induction of IL-10. IL-10 activates Stat1, which promotes apoptosis, and Stat3, which inhibits it. The balance between these two opposing activities falls in favour of cell survival. The phosphorylation-dependent activation of the Stats requires PKR activity, although PKR can also cause Stat dephosphorylation via the protein phosphatase TC-PTP. High level expression of the EBERs is suggested to inhibit preferentially the activation of Stat1 and/or the inactivation of Stat3, through the ability of the viral RNAs to prevent PKR activation, favouring the inhibition of apoptosis. Blockade of the mTOR pathway by rapamycin is proposed to favour apoptosis through inhibition of the anti-apoptotic effects of IL-10.

Dr Mariam Al-Shamsi: Dr Al-Shamsi’s research suppression of the development and interest and activity include: pathogenesis of Type 1 diabetes either through regulation of IL-10 production from IL-10 1. Understanding the role of interleukin-27 producing cells or through regulation of (IL-27) anti-inflammatory role of IL-27 during macrophages activation and function. the effector phase in the model of MLD-STZ induced diabetes. So far, our preliminary Dr Agnes Sonnevend: data shows enhanced diabetes induction in Dr Sonnevend’s laboratory has been interested C57BL/6 male mice as presented by elevated in the molecular epidemiology of various, mostly blood glucose levels in the experimental antibiotic resistant pathogens. They actively mouse groups treated with exogenous took part in the development of one of the first recombinant IL-27 as compared to the control Multi Locus Sequence Typing system for group (Figure 6). Our theory based on Campylobacter jejuni. Currently, in cooperation evidence that IL-27 inhibits autoimmunity with a Hungarian group they are carrying out by immunoregulating the secretion of the detailed molecular analysis on human isolates potent pro-inflammatory IL-17 by TH-17 in to reveal the role of different topoisomerase EAE. In addition, reports in EAE suggested mutation in the development of rapidly that immunoregulatory role of IL-27 is increasing fluoroquinolone resistance. controlled by time of administration. When joining the FMHS last year, Dr Sonnevend 2.Studying the role of B lymphocyte induced started investigating the incidence of Panton- maturation protein-1 (Blimp-1) in the possible Valentine Leukocidin (PVL)-producing Staphylococcus aureus (SA) and has found it high in methicillin sensitive SA (MSSA) and methicillin-resistant S.aureus (MRSA), as well. Currently the laboratory carries out molecular genetic investigations to find the possible link between the PVL production in the two groups i.e. the antibiotic sensitive and resistant groups of strains. Also, they are investigating the possible role of biofilm formation in association of PVL production in methicillin-sensitive as well as methicillin-resistant S.aureus.

Beyond that is cooperation with Prof. Michael Conlon , Department of Biochemistry, to study the effect of various peptides on different microorganisms.

42 Department of Medical Microbiology & Immunology

Rotimi VO, Jamal W, Pál T, for the Use of MMTV Vectors in Articles in Sonnevend A, Dimitrov TS, Albert Human Gene Therapy. Presented Peer-reviewed MJ. (2008). Emergence of at the Fifth Scientific Conference for multidrug-resistant Salmonella GCC Medical Students, Bahrain. Journals spp. and isolates with reduced susceptibility to ciprofloxacin in al-Ramadi B. (2008). Immunotherapy al-Ramadi BK, Fernandez-Cabezudo Kuwait and the United Arab of Cancer. 5th Dubai International MJ, El-Hasasna H, Al-Salam S, Emirates. Diagn Microbiol Infect Conference for Medical Sciences, Attoub S, Xu D, Chouaib S. (2008). Dis. 60:71-7. Dubai, UAE. Attenuated bacteria as effectors in cancer immunotherapy. Annals Rotimi VO, Jamal W, Pál T, al-Ramadi B. (2008). Tumor New York Academy of Sciences. Sonnevend A, Dimitrov TS, Albert Immunotherapy Using Cytokine- 1138:351-357. MJ. (2008). Emergence of CTX-M- Expressing Bacteria. 3rd Al Ain 15 type ESBL producing International Immunology Meeting, Ellis M, al-Ramadi B, Finkelman F, Salmonella spp. in Kuwait and the Al Ain, UAE. Hedstrom U, Kristensen J, Alizadeh United Arab Emirates. J Med H, Klingspor L. (2008). Assessment Microbiol 57:881-886. Al Dhaheri N, Al Shamsi N, Al Awadi of the clinical utility of serial ‚-D F, Rizvi TA. (2008). Reciprocal glucan concentrations in patients Saadi H, Nagelkerke N, Carruthers Packaging of Mouse Mammary with persistent neutropenic fever. SG, Benedict S, Abdulkhalik S, Reed Tumor Virus (MMTV) by Journal of Medical Microbiology R, Lukic, M Nicholls MG. (2008). Heterologous Mason-Pfizer Monkey 57: 287-295. Association of TCF7L2 Virus (MPMV) Proteins. Presented at polymorphism with diabetes the Ninth UAE University Annual Fernandez-Cabezudo MJ, mellitus, metabolic syndrome, and Research Conference, Al Ain. Azimullah S, Nurulain SM, markers of beta cell function and Mechkarska M, Lorke DE, Petroianu insulin resistance in a population- El-Hasasna H, Fernandez-Cabezudo GA, al-Ramadi BK. (2008). The based sample of Emirati subjects. MJ, Al-Salam S, Bashir G, Attoub S, organophosphate Paraoxon has Diabetes Research and Clinical Chouaib S, al-Ramadi BK. (2008).The no demonstrable effect on the Practice 80: 392 – 398. anti-tumor activity of systemically- murine immune system following administered IL2-expressing subchronic low dose exposure. Int. Salmonella correlates with J. Immunopathology & decreased angiogenesis and Pharmacology 21:891-901. k enhanced tumor apoptosis.The 3rd Al Ain International Immunology Kenyon JC, Ghazawi A, Cheung Meeting, Al Ain, United Arab WKS, Phillip PS, RizviTA, Lever AML. Emirates. (2008). The secondary structure Books, Chapters, of the 5’ end of the FIV genome Reviews and El-Hasasna H, Fernandez-Cabezudo reveals a long range interaction MJ, El-Wasila M, Al-Salam S, Bashir G, between R/U5 and gag sequence, Editorials Chouaib S, al-Ramadi BK. (2008). and a large, stable stem loop. RNA, al-Ramadi B, Hayday A, Schwaeble Oral administration of TNF·- 14: 2597-2608, 2008. W. (2008). Immunology in the expressing Salmonella inhibits Arabian desert. Nature melanoma cell growth and prolongs Nagy G, Pál T. (2008). Immunology 9:699-703. host survival independent of intra- Lipopolysaccharide: a tool and tumoral bacterial accumulation.The target in enterobacterial vaccine 3rd Al Ain International Immunology development. Biological Meeting, Al Ain, United Arab Chemistry 389:513-520. k Emirates. Nagy G, EmŒdy L, Pál T. (2008). Fernandez-Cabezudo MJ, Ullah A, Strategies for the development of Proceedings, Nurulain SM, al-Ramadi BK, vaccines conferring broad- Petroianu, GA. (2008). Assessment of spectrum protection. Int. J. Med. Conferences, immunologic parameters following Microbiol, 298:379-395. Invited lectures, exposure to organophosphate- containing pesticides.The 3rd Al Ain Nagy G, Palkovics T, Otto A, Kusch Web Sites and International Immunology Meeting, H, Kocsis B, Dobrindt U, Engelmann Others Al Ain, United Arab Emirates. S, Hecker M, Emödy L, PálT, Hacker J. (2008). "Gently Rough": The Al Dhaheri N, Al Shamsi N, Al Awadi Fernandez-Cabezudo MJ, Vaccine Potential of a Salmonella F, Rizvi TA. (2008). Cross Packaging Mechkarska M, al-Ramadi BK. (2008). enterica Regulatory of Mouse Mammary Tumor Virus Modulation of macrophages pro- Lipopolysaccharide Mutant. J (MMTV) RNA by Mason-Pfizer inflammatory functions by cytokine- Infect Dis. 198:1699-1706 MonkeyVirus (MPMV): Implications expressing bacteria. Frontiers in

43 Department of Medical Microbiology & Immunology

Immunology Research International [2008]. streptozotocin induced diabetes Meeting. Florence, Italy. and spontaneous diabetes in NOD Khan G. (2008). Hodgkin Lymphoma Prof.TA Rizvi [PI]. mice. and Cervical Lymphadenopathy. Pak Role of the Intervening Sequences J Med Sci. 24: 348-350. between the Major Packaging Terry Fox Cancer Research Grant Determinants of Mason-Pfizer 2008 Kenyon JC, Ghazawi A, RizviTA, Lever Monkey Virus (MPMV) in RNA AML. (2008). The FIV Packaging Packaging and Propagation [2007- Prof BK al-Ramadi [PI]. Determinants: A Structure/Function 2008] Cytokine-expressing Salmonella Analysis. RNA Meeting, Berlin. strains as effective biological Dr A Sonnevend [PI]. therapy against cancer: analysis Kenyon JC, Ghazawi A, RizviTA, Lever Incidence and characteristics of of the mechanisms underlying the AML. (2008). The FIV Packaging Panton-Valentine Leukocidine inhibition of tumor growth. Determinants: A Structure/Function positive Staphylococcus aureus in Analysis. Society for General Al Ain [2008-2009]. Others Microbiology Meeting, Edinburgh. Dr A Sonnevend [PI]. Arab Science & Technology Mechkarska M, al-Ramadi BK, and Prevalence of different pheno- and Foundation, Sharjah, UAE. Fernandez-Cabezudo, MJ. (2008). genotypes of macrolide- Invasion-independent modulation lincosamide-streptogramin B Dr H El-Taji & Prof BK al-Ramadi of macrophage activation by resistance among Staphylococcus [PIs]. bacteria-expressed cytokines. The aureus clinical isolates in Al Evaluation of the effect of honey 3rd Al Ain International Ain.[Seed Grant] alone or in combination with Immunology Meeting, Al Ain, United standard chemotherapy on Arab Emirates. Dr G Khan [PI]. Establishment of a inhibition of proliferation and sensitive protocol for the viability of estrogen receptor- Ojali SM, Ullah A, Bashir G, El- detection of EBV in paraffin- negative breast cancer cell line. Hasasna H, Fernandez-Cabezudo embedded material for MJ, al-Ramadi BK. (2008). investigating the role of the virus Wellcome Trust Collaborative Enhancement of immune in the pathogenesis of EBV- Project Grant responsiveness by attenuated associated Hodgkin lymphoma. interferon gamma-expressing [Seed Grant] Prof TA Rizvi and Dr A Lever [PIs]. Salmonella vaccine. The 3rd Al Ain Structure and Function Analysis International Immunology Meeting, UAEU individual Grant 2008 of RNA Packaging in the Lentivirus Al Ain, United Arab Emirates. FIV. Prof TA. Rizvi [PI]. Ullah A, El-Hasasna H, Mechkarska Role of FIV Gag stem loop M, R. Flavell, Fernandez-Cabezudo structure in RNA packaging and k MJ, al-Ramadi BK. (2008). Role of propagation: Implications for the MyD88 expression andTLR signaling design of FIV-based vectors for in immunity to Salmonella infection. human gene therapy. The 3rd Al Ain International Immunology Meeting, Al Ain, United Prof ML Lukic [PI]. Arab Emirates. Galectin-3 in Autoimmune Inflammation in the Central k Nervous Systems. UAEU Interdisciplinary Grant Research Grants 2008 Prof ML Lukic [PI]. FMHS New Research Grant Galectin-3 in Autoimmune Inflammation in the Central Prof. B. K. al-Ramadi [PI]. Nervous Systems. The role of Toll-like receptors in host defence against microbial Hamdan Award Medical infections. [2006-2008] Research Grant 2008

Prof. T Pal [PI]. Prof ML Lukic [PI]. Geno-, and phenotyping of Roles ofTh-1 andTh-17 cells in the atypical Enteropathogenic pathogenesis of diabetes: an Escherichia coli isolated in the UAE analysis in multiple low dose

44 Department of Medical Microbiology & Immunology

Standing left to right: Jahabar Ali, Allen Shahin, Ahmed El-Haj, Ahmed Al-Hakim, Tibor Pal, Basel al-Ramadi, Tahir Rizvi, Hashik Majeed Seated left to right: Professor M L Lukic (Chairman), Pretty Susan Philip, Nawal Juma, 2008MaureenMicrobiology Dawood, Erika Zilahi, Preethi Jayanth, Senarath Dissanayake,

http://www.fmhs.uaeu.ac./Department of Microbiology/Immunology Tel: 7672000 / Fax: 7671966

45 Department of Obstetrics & Gynaecology

Research Profile

Professor & Chair The Research interests in the department are in Prof Mutairu Ezimokhai Obstetrics, Fetal Medicine, and Minimal Access Associate Professor: Dr Hisham Mirghani Gynaecology Surgery, Women’s Health Education Assistant Professor: and Awareness. Dr Sami J George Teaching Assistant: Dr Munira Mohammed Obstetrics Medical Research Specialist: a) Pathophysiology of Pregnancy Dr Nawal Osman Professor M. Ezimokhai is interested in Pathophysiology of Research Nurse: Pregnancy and medical disorder in Pregnancy. Expertise is in Mrs Flora D Lone working with vascular and uterine smooth muscles. Medical Secretary: Ms Kamala Manickam b) Fetal Medicine Secretary: Dr. H. Mirghani’s major area of research interest is Mrs Jiji George • Fetal response to maternal fasting and maternal blood glucose • Research interest in Fetal changes in GDM. • Interest in ultrasound training and assessment. We have demonstrated for the first time the use of cumulative sum (CUSUM) analysis in assessing trainees’ proficiency at fetal biometry measurements. • Fetal anomalies

c) Minimal Access Gynaecology Surgery, Women’s Health Education and Awareness, Dr. S. George is interested in • women’s Health Education and awareness. • Special interest in Endometriosis, Polycystic Ovary Syndrome and infertility, • Contraception and Urogynecology, • All Gynecologic laparoscopic and hysteroscopic surgeries. Department of Obstetrics and Gynaecology

Articles in Peer- Proceedings, reviewed Journals Conferences, Invited lectures, Hamdan MA, Almalik MH, Mirghani HM. (2008). Early administration Web Sites and of enzyme replacement therapy Others for Pompe disease: Short-term follow up results. J Inherit Metab Mirghani H, Bekdache G, Begum Dis ;Dec 12. (Epub ahead of print). M, Khan F. (2008). Fetal body measurement in gestational Lammers WJ, Mirghani H, Stephen diabetes. 18th World Congress on B, Dhanasekaran S, Wahab A, Al Ultrasound in Obstetrics & Sultan MA, Abazer F. (2008). Gynecology.Chicago, USA (Poster), Patterns of electrical propagation August 24th – 28th 2008. in the intact pregnant guinea pig uterus. Am J Physiol, March;294(3): Mirghani H. (2008). Management R919-R928. of IUGR. Fetal Medicine: A multidisciplinary approach. International meeting for World k Association of Perinatal Medicine, Khartoum, Sudan, 14-16 November 2008.

George S. (2008). Pelvic floor dysfunction. Role of Laparoscopy in Gynaecology. Arab Health Congress organized by Dubai International Convention and Exhibition, Dubai, UAE.

George S. (2008). Expert Meeting, Mirena IUD, Rome, Italy. k

Obs & Gyn http://www.fmhs.uaeu.ac.ae/Departments/Obs&Gyn2008 Tel : 7672000 / Fax : 7672067

47 Department of Paediatrics

Research Profile

Professor & Chair: Genetics/Birth Defects Prof P Sasidharan (including Neuro-Genetics) Professor: The department has a strong research interest in Prof Y M Abdulrazzaq Prof A Souid the area of birth defect/dysmorphology and brain Prof L Al-Gazali malformations including nervous system Prof S A Uduman dysgenesis. Several disorders have been studied Associate Professor: Dr E Aburawi at the clinical and molecular level. Dr S Bharwani Dr H Narchi Assistant Professor: For example, familial and sporadic forms of cerebral dysgenesis Dr S Al-Hammadi were studied and a new type of agyria-pachygyria associated with Dr F Al-Jasmi agenesis of corpus callosum was characterized, a severe form of Dr R Al- Mahmoud a syndrome of myotonia and bone dysplasia [Stüve-Wiedemann Dr M Al-Samri Syndrome (SWS)] was identified to be common in the population Dr A Al-Suwaidi of the UAE. Founder mutation in the Leukemia inhibitory factor Dr G Balhaj receptor (LIFR) was found in all families affected with SWS in this Research Medical population. A birth defect registry for Al Ain Medical District was Specialist: established by the department, which has gained membership Mr T Pramathan of the International Clearing House for Birth Defects. Several Mr J Kochiyil studies from this register were published identifying the Research Assistant: incidence and pattern of the various types of birth defects in this Ms A Al-Kendi population together with establishing risk factors involved in Medical Secretary: their etiology. Ms R Clemente Secretary: In addition, the group has been investigating the reasons why some Ms M Al-Badwawi anti-epileptic drugs (vigabatrin, lamotrigine) ingested by women during pregnancy cause neural tube and other defects. Departmental researches have already established that these drugs are teratogenic. It was established that methionine was 5 times lower in embryo of treated pregnant mice than in non- treated controls. Studies are ongoing to determine the impact of folic acid and vitamin B12 supplementation on the frequency of occurrence of anomalies in animal models.

Aflatoxins are commonly found in nuts, grains and have been found to be increased in pregnant women and their offspring. Study is ongoing to determine teratogenic effects of aflatoxins in mice. Department of Pediatrics

The department is also interested in mapping status of Vitamin D levels among adolescents recessive genetic disorders using the concept of and female pediatric patients in UAE. Since Vit. homozygosity mapping, particularly disorders D has a pluripotent role in the body and has which are common or unique to this population. been found to be deficient among women and For example, a gene for Joubert syndrome, newborns in UAE (from previous studies from which seems to be common in Arabs, was our department), this important project will mapped to chromosome 9q34.3 and genetic provide information which will lead to heterogeneity was established. Subsequently interventional studies in the future. other genes for Joubert Syndrome were mapped and mutations were identified in families from Role of Vitamin D in Lung Development UAE. Another new type of epiphyseal dysplasia Since the majority of alveolar development was described in a family from UAE and a gene occurs postnatally, the interaction between Vit. was mapped to chromosome 15q26. Several D and factors responsible for alveolarization, other disorders are currently being investigated particularly VEGF will be studied. Thus the role using the same concept. of Vit. D in the epithelial and mesenchymal interactions during early lung development will Metabolic disorders are common in the UAE. be investigated.This study has significant clinical The department is active in establishing the implications in Pediatrics as abnormal lung prevalence of different metabolic disorders in development and airway reactivity frequently the UAE population. lead to significant morbidity in later life. We have observed a very high incidence of asthma An ongoing study aims to determine prevalence among the pediatric population in Al Ain. of alcaptonuria within UAE population. Other areas of research Perinatal nutrition and nutritional Other areas of research include clinical and disorders immunological aspects of hepatitis C, The department is involved in studies on seroepidemiology and neonatal screening of micronutrients abnormalities in pregnancy and CMV and other congenital infections. Clinical the effect on the fetus/newborn.The preliminary research in neurology includes profile of results suggest that micronutrient deficiency is epilepsy and drug therapy of epilepsy in the common in pregnancy and outcome studies are UAE as well as brain imaging and epidemiology in progress. of cerebral palsy.

The department has been active through the Other activities of the department include years in experiments involving amino acids establishing normal growth charts for children levels at different ages in the UAE population from the UAE from ages 0-18 years, and the size and showed that some amino acids were at birth of infants born to UAE nationals. These abnormally high in newborn infants using the growth charts will provide the first standards for then available parenteral amino acid solution. assessing intrauterine and postnatal physical This led to a change in the solutions used in growth of UAE newly born infants and children. the Medical District. The role of food allergy and airway reactivity is The group working on reproductive toxicology another area of interest in our department.This has established that aflatoxin (a fungus toxin) is being investigated in a population based contamination of foods is very common, and approach. that aflatoxins have been detected in blood of pregnant women and their offspring in larger Factors responsible for inflammatory bowel amounts than is acceptable. Measurement of disease in the pediatric population is an area of aflatoxin in breast milk of lactating mothers is interest and studies on animal models are being in progress.The results will give a much clearer initiated now. picture of exposure of infants to aflatoxins. Outcomes of prematurity, especially in the very- Vitamin D status among pediatric low birthweight and extremely low birthweight population in UAE groups in the local population. This population based study will reveal the

49 Department of Pediatrics

Disorders (JSRD) Study Group, urinary tract infections: do they Articles in Peer- Valente EM, Woods CG, Gleeson have different antibiotic reviewed Journals JG (2008). Mutations in the cilia susceptibilities?” J Chemother, gene ARL13B lead to Joubert 20(4):472-7. Abdulrazzaq YM, Al Kendi A, syndrome and related disorders. Nagelkerke N (2008). Child Care Am J Hum Genet.,83(2):170-179. Narchi H, Basak R (2008). Bacterial Practice in the United Arab tracheitis- Not always primary.Turk Emirates:The ESACCIPS study. Acta Dawodu A, Bener A, Koutouby GA, J Pediatr, 50: 409-411. Paediatrica; 97: 590–595. Varady E, Abdulrazzaq Y (2008). Size at birth in a rapidly developing Narchi H, Donovan R (2008). Renal Abdulrazzaq YM, Moussa M, economy: Intrauterine growth power doppler ultrasound does Nagelkerke N (2008). National pattern of UAE infants born to not predict renal scarring after Growth Charts for the United Arab healthy mothers. Annals of Human urinary tract infection. Scot Med J, Emirates. Journal of Biology; 35(6): 615 – 623. 53(4):7-10. Epidemiology;18(6):295-303. Hatchette T, Tipples G, Peters G, Narchi H (2008). Assessment and Abdulrazzaq YM, Osman N, Alsuwaidi A, Zhou J, Mailman T management of non-nephrotic Kosanovic M, Adem A (2008).Trace (2008). Foscarnet SalvageTherapy range proteinuria in children. Sri element content in plasma and for Acyclovir-Resistant Varicella Lanka Journal of Child Health; 37: breast milk of well nourished Zoster: Report of a Novel 85-92. women. J Environ Sci Health 2008; Thymidine Kinase Mutation and A43 (5):329-334. Review of the Literature. Pediatric Padmanabhan R, AbdulrazzaqYM, Infectious Diseases Journal;27(1). Bastaki SMA, Shafiullah MM (2008). Al-Gazali L, Hertecant J, Algawi K., Intrauterine Growth Restriction El Teraifi H (2008). A new Khetyar M, Tinworth L, Syrris P, and Skeletal Variations in Mouse autosomal recessive syndrome of Abushaban L, Abdulazzaq Y, Fetuses Induced by Vigabatrin ocular colobomas. Ichhthyosis, Silengo M, Carvalho J, Carter N Administered at Preimplantation brain malformations and (2008). NKX2.5/NKX2.6 Mutations Stages of Development. Congenit endocrine abnormalities in an are not a Common Cause of Anom;48(1):29-39. inbred emirati family. Am J Med IsolatedType 1Truncus Arteriosus Genet Part A, 146A:813-819. in a Small Cohort of Multiethnic Rauch A,Theil CT, Schindler D, Wick Cases. Genet Test;12(4):467-469. U, Crow YJ, Ekici AB, van Essen Aj, Amirlak I, Al Dhaheri W, Narchi H Goecke TO, Al-Gazali L, (2008). Dilated cardiomyopathy Kosanovic M, Adem A, Jokanovic Chrzanowska KH, Zweier C, secondary to nutritional rickets. M, Abdulrazzaq YM (2008). Brunner HG, Becker K, Curry CJ, Ann Trop Paediatr., 28:227–230. Simultaneous determination of Dallapiccola B, Devriendt K, Dorfler cadmium, mercury, lead, arsenic, A, Kinning E, Megarbane A, Amirlak I, Narchi H (2008). Isolated copper and zinc in human breast Meinecke P, Semple RK, Spranger orbital pseudotumor as the milk by ICP-MS/microwave S, Toutain A, Trembath RC, VoB E, presenting sign of systemic lupus digestion. Analytical Letters; Wilson L, Hennekam R, de Zegher erythematosus. J Pediatr Ophthalmol 41(3):406 – 416. F, Dorr HG, Reis A (2008). Strabismus, 45(1):51-54. “Mutations in the pericentrin Murthy SK, Malhotra AK, Jacob PS, (PCNT) gene cause primordial Brancati F,Travagilini L, Zablocka D, Naveed S, Al-Rowaished EEM, Mani dwarfism.”Science, 319(5864)816- Boltshauser E, Accorsi P,Montagna S, Padariyakam S, Pramathan R, 819. G, Silhavy JL, Barrano G, Bertini E, Lyndell S, Nath R, Ridha A, Al-Ali Emma F, Rigoli L, International JSRD MT, Al-Gazali L (2008). Anaploid Sasidharan P (2008). Evaluation Study Group, Dallapiccola B, supernumerary marker of Newborn Cyanosis. BMJ Gleeson JG, Valente EM (2008). chromosome characterized by Monograph, July 2008. RPGRIP1L mutations are mainly array-CGH and FISH as inv dup associated with the cerebello-renal (3)(qter-q26.1::q26.1-qter) in a Sugimoto N, Rui T, Yang M, phenotype of joubert syndrom – child with dysmorphic features Bharwani S, Handa O, Yoshida N, related disorders. Clin Genet., and streaky pigmentation. Yoshikawa T, Kvietys PR (2008). 74(2):164-170. Molecular Cytogenetics, 1(1):19. Points of control exerted along the macrophage-endothelial cell- Cantegrel V, Silhavy JL, Bielas SL, Narchi H, Al Marah M (2008). Does polymorphonuclear neutrophil Swistun D, Marsh SE, Bertrand JY, vesicoureteral reflux increase axis by PECAM-1 in the innate Attie-BitachT, Holden KR, Dobyns antibiotic resistance in pediatric immune response of acute colonic WB, Traver D, Al-Gazali L, Ali BR, urinary tract infections. MAM. inflammation. J Immunol; Linder TH, Caspary T, Otto EA, Paediatrics me; 13 (4): 91-94. 181(3):2145-54. Hildebrandt F, Gooding C, Johnson CA, Bennett C, The International Narchi H, Al-Hamdani M (2008). Suryadevara M, Schurman SJ, Joubert Syndrome Related First and recurrent pediatric Landas SK, Philip A, Gerlach CB,

50 Department of Pediatrics

Tavares T, Souid A-K (2008). Sadowitz PD, Souid A-K (2008). Systemic calciphylaxis. Pediatric Acute childhood immune Proceedings, Blood and Cancer; 51-548-550. thrombocytopenic purpura and Conferences, other platelet disorders. In: Baren Tao Z, Goodisman J, Souid A-K JM, Rothrock SG, Brennan JA, Invited lectures, (2008). Oxygen measurement via Brown L, eds: Pediatric Emergency Web Sites and phosphorescence: reaction of Medicine. 1st ed. Saunders sodium dithionite with dissolved (Elsevier); 912-916. Others. oxygen. The Journal of Physical Abdulrazzaq YM. (2008). Chemistry A;112:1511-1518. Sadowitz PD, Souid A-K (2008). Alkaptonuria in the UAE: XXI Cancer and cancer-related European Congress of Perinatal Tao Z, Jones E, Goodisman J, Souid complications in children. In: Medicine Istanbul, Turkey, A-K (2008). Quantitative measure Baren JM, Rothrock SG, Brennan September 10 - 13, 2008. of cytotoxicity of anticancer drugs JA, Brown L, eds: Pediatric and other agents. Analytical Emergency Medicine. 1st ed. Abdulrazzaq YM. (2008). Breast Biochemistry; 381:43-52. Saunders (Elsevier);905-911. feeding in Premature infants, The 5th Arab Neonatal Forum Tao Z, Morrow MP,AsefaT, Sharma Souid A-K, Rosales LG, Bou Aram B Conference, Bahrain, 15-17 KK, Duncan C, Anan A, Penefsky (2008). Utilizing blood bank January 2008. HS, Goodisman J, Souid A-K (2008). resources, transfusion reactions Mesoporous silica nanoparticles and complications. In: Baren JM, Abdulrazzaq YM. (2008). inhibit cellular respiration. Nano Rothrock SG, Brennan JA, Brown Ghostwriting- a bane or a boon? Letter; 8:1517-1526. L, eds: Pediatric Emergency The Fourth Regional Conference Medicine. 1st ed. Saunders on Medical Journals in the Eastern van Haelst MM, Maiburg M, Baujat (Elsevier); 931-935. Mediterranean Region, Kingdom G, Jadeja S, Monti E, Bland E, Pearce of Bahrain, 5-7 November 2008. K, Fraser Syndrome Collaboration Souid A-K (2008). Disorders of Group, Hennekam RC, Scambler coagulation. In: Baren JM, AbdulrazzaqYM. (2008). Neonatal PJ. (2008). Molecular study of 33 Rothrock SG, Brennan JA, Brown database, comparison with that of families with Fraser syndrome new L, eds: Pediatric Emergency Vermont Oxford Network, 10th data and mutation review. Am J Medicine. 1st ed. Saunders anniversary of the National Med Genet, 146A(17):2252-2257. (Elsevier); 917-926. Collaboration Perinatal Neonatal Network, Beirut, Lebanon, 20-22 k k November 2008. Abdulrazzaq YM. (2008). R58fs mutation in HGO gene in a family Published in the UAE. 2nd Al-Ain Books, Chapters, International Genetics Conference, Abstracts, Al Ain, UAE, 28-30 October 2008. Reviews and letters, Editorials Abdulrazzaq YM. (2008). Random Correspondence Sample Screening and Genotyping Confirming an Old Mutation of an Bou Aram B, Souid A-K (2008). Narchi H, Skinner A, Williams B Old Disease. 2nd Congress of the Hemolytic uremic syndrome. In: (2008). Small for gestational age European Academy of Paediatrics- Baren JM, Rothrock SG, Brennan neonates- Are we missing some EAP, Nice, France, 24-28 October JA, Brown L, eds: Pediatric by only using standard population 2008. Emergency Medicine. 1st ed. growth standards- and does it Saunders (Elsevier);927-930. matter? Abstracts of the XXI Abdulrazzaq YM. (2008).Feeding European Congress on Perinatal in Premature infants, 1st RAK Hingre B, Reiners CH, Souid A-K Medicine, 2008. In: the Journal of PanArab congress in pediatric (2008). Newborn evaluation. In: Maternal-Fetal and Neonatal gastroenterology, Hepatology and Ebell MH, Editor: Evidence At Hand Medicine; 21(1): 52-53. Nutrition, Ras Al Khaima, 11-13 (John Wiley & Sons). March 2008.

Ross AM, Bharwani S, Abdulrazzaq YM. (2008). Late Gastrointestinal Disorders. In: k preterm infants and their Alario AJ, ed., Practical Guide to complications, 10th anniversary of the Care of the Pediatric Patient: the National Collaboration Mosby Elsevier, Inc., 2nd Edition Perinatal Neonatal Network, Beirut, August; 433-469. Lebanon, 20-22 November 2008.

51 Department of Pediatrics

Al-Awadhi AM, Al-Suwaidi SS, Victoria, BC, Canada. ultrasound. 9th Annual Research Hume AN, Buttgereit John, Bader Conference, United Arab Emirates A, Al-Gazali L, Ali BR (2008). John A, Hertecant J, Al-Gazali L, University, Al Ain, UAE, April 2008. Defective Cellular Trafficking of Karuvanterida NS, Ali BR. (2008). NPR-B is the Major Mechanism A novel Mutation in ARG1 gene is Narchi H. (2008). Changes in Underlying Anomeromelic Responsible for Arginase antibiotic resistance of Dysplasia Maroutex Type. Deficiency in an Asian family from uropathogens. 9th Annual International Genetic Conference, UAE. International Genetic Research Conference, United Arab Al Ain, Oct. 27-30, 2008. Conference, Al Ain, Oct. 27-30, Emirates University, Al Ain, UAE, 2008. April 2008. Al-Gazali L. (2008). Autosomal Recessive Disorders: The UAE Langer RD, Al-Gazali L, Raupp P, Narchi H. (2008). Small for Perspective. International Genetic Varady E. (2008). Radiographic gestational age neonates- are we Conference, Al Ain, Oct. 27-30, findings in Newborns and missing some by only using 2008. Survivors with Stuve-Wiedemann standard population growth Syndrome. International Genetic standards and does it matter? XXI Al-Gazali L. (2008). Autosomal Conference, Al Ain, Oct. 27-30, European Congress of Perinatal Recessive Disorders: an overview 2008. Medicine. Istanbul, Turkey. from the UAE. French Academy of September 2008. Science, March 2008. Narchi H. (2008). Constipation and defecation disorders in childhood. Pober BR, Noonan KM, Al-Gazali L, Al-Gazali L, Akawi NA, Shather B, 11th Annual Congress of the Sri Bieth E, Chassning C, Clark R, Kaplan N, Algawi K, Ali BR. (2008). Lanka College of Paediatricians. Coletti C, Devriendt K, Donnai D, Anterior Segment Anomalies of Kandy, Sri Lanka, June 2008. Furey A, Golabi M, Graham JM, the eye Growth Retardation Holder S, Hofer H, Norner M, Associated with Hypoplastic Narchi H. (2008). Non-nephrotic Kantarei S, Lacassie Y, Longoni M, Pituitary Gland and Endocrine range proteinuria. 11th Annual Mcpherson E, Prescot K, Ragee N, Abnormalities: Jung Syndrome or Congress of the Sri Lanka College Russel M, Scott DA,Teebi A,Toriello a New Syndrome? International of Paediatricians. Kandy, Sri Lanka, H, van der Crabben SN, Yates L, Genetic Conference, Al Ain, Oct. June 2008. Donahoe PK (2008). Findings 27-30, 2008. amongst LRP2 Mutation Positive Narchi H. (2008). Recent advances versus LRP2 Mutation Negative Al-Hammadi S (2008). Prevalence in the diagnosis of tuberculosis. Cases Referred for the Diagnosis of of Food Allergy Among Children of 11th Annual Congress of the Sri Donnai-Barrow Syndrome. Al Ain City, UAE. The 9th ARC, UAE Lanka College of Paediatricians. Manchester Birth Defect University, Al Ain City, UAE. Kandy, Sri Lanka, June 2008. Conference, Manchester, UK, Oct. 2008. Al-Hammadi S (2008). Food Narchi H. (2008). Large for Allergy (2008). The 2nd Annual gestational age neonates- are we Sasidharan P (2008). Role of Pediatric Conference of Tawam- diagnosing them all by using Antenatal Steroids in women at Johns Hopkins Medicine, Al Ain standard population growth 32-34 wks of gestation: neonatal City. standards? 2nd Congress of the outcome. Annual meeting of the European Academy of Paediatrics PAS at Honolulu, May, 2008. Al-Hammadi S (2008). Bronchial (EAP). Nice, France, October 2008. Asthma in Children. The 3rd Sasidharan P, Al Haqani N. (2008). Yemeni-Saudi Conference of Narchi H. (2008). Which red blood Impact of the introduction of a Clinical Immunology and cell indices better indicate iron Private Health Care Insurance on Allergology, Sana’a, Yemen. deficiency in a population with a Pediatric Health care Delivery in a high prevalence of alpha developing country. Annual PAS Al-Hammadi S (2008). Natural thalassaemia? 2nd Congress of meeting at Honolulu, May 2008. History of Atopic Diseases (Allergic the European Academy of March). The 3rd Yemeni-Saudi Paediatrics (EAP). Nice, France, Sasidharan P, Saleh L, Salman N. Conference of Clinical October 2008. (2008). Role of Palivizumab Immunology and Allergology, administration when there is an Sana’a, Yemen. Narchi H. (2008). Third trimester RSV outbreak in the NICU: short antenatal ultrasound scan and term neonatal outcome in a Al Harbi S, Alsuwaidi A, Casseele P, foetal urinary tract anomalies. 9th developing country. Annual PAS Aranetta R. (2008). Adenovirus Annual Research Conference, meeting at Honolulu, May 2008. Lower respiratory tract infections United Arab Emirates University, in children: 15 years Manitoba Al Ain, UAE, April 2008. Uduman S, Sasidharan P. (2008). experience. 85th annual Role of adult contacts in pediatric conference of the Canadian Narchi H. (2008). Renal scarring tuberculosis in UAE. Annual PAS Pediatric Society, June 2008, after UTI and renal power meeting at Honolulu, May, 2008.

52 Department of Pediatrics

Uduman S, Sasidharan P. (2008). Off- season RSV outbreak in a tertiary care NICU in UAE. Annual meeting of PAS at Honolulu, May 2008. k

Research Grants

Sheikh Hamdan Award for Medical Sciences Abdulrazzaq YM, Padmanahan R, Bastaki S, et al (2008). Reproductive Toxicologic Studies on Lamotrigine (LTG) in the Mouse: Effect of Folate Supplementation. k

Standing left to right: Dr. A. Al Suwaidi; Dr. S. Al Hammadi; Ms. Rose Clemente; Dr. S. Bharwani; Prof. A. Souid; Dr. H. Narchi; Mr. J. Kochiyil; Mr. T. Pramathan; Dr. M. T. Al Samri; Mr. Jamal CK Seated left to right: Dr. F. Al Jasmi; Prof. L. Al Gazali; Prof. S. A. Uduman; Prof. P. Sasidharan; Prof. Y.M. Abdulrazzaq; Dr. E. Aburawi 2008Pediatrics

http://www.fmhs.uaeu.ac.ae/Departments/Paediatrics Tel : 7672000 / Fax : 7672067

53 Department of Pathology

Research Profile

Associate Professor & Pathology is a wide-ranging discipline of Acting Chair: laboratory medicine. It covers several research Dr A Castella Professor: fields, including histopathology, cytology, Prof MM Agarwal laboratory hematology, clinical chemistry, Associate Professor: genetics and molecular biology. Dr Bassam Ali Dr SM Chong Assistant Professor: Hematopathology: (Dr. Antonio Castella) Dr S Al Salam Lymphomas are malignant monoclonal disorders of the lymphatic Teaching Assistant: system, which show diverse clinical features, pathology and Dr A Al Bawardi outcome. The pathological classifications are controversial, Dr S Al Marzooqi especially with regard to non-Hodgkin's lymphomas (NHL). In Medical Research recent years new classifications have been proposed which are Specialist: based on modern concepts of lymphocyte function. The latest Ms A Mathew classifications of lymphomas (REALand WHO) are an attempt Ms M Sudhadevi to resolve the lack of uniformity in the reporting of malignant Medical Secretary: lymphomas by defining the different types according to Ms K Al Ghanem morphology and immunology as well as cytogenetics. Research Assistant: Ms N Akawi Although lymphomas show a worldwide distribution, geographical Mr N Karavantevide variations in their histopathologic pattern, especially NHL, are well recognized. However, in the Middle East, and specifically in the Gulf countries, there was a paucity of data concerning the patterns of histopathologic subtypes of lymphomas.

The Pathology Department undertook a project, in collaboration with Tawam and Al Ain Hospitals, to study the pattern of lymphomas in the UAE.

The aim of this study was to analyze the distribution of the various pathologic types of lymphoma in the native Arab population of the UAE. More than 200 National patients with lymphoma were studied. The cases were examined morphologically and immunohistochemically with an extensive panel of monoclonal antibodies, and are classified according to the revised European-American classification of lymphoid neoplasms (REAL). The results were compared with the distribution of lymphomas in other Asian and Western countries. Department of Pathology

In addition, a second project studied the protein- I and in situ hybridization for EBV differences of the distribution pattern of NHL encoded RNA (EBER). EBV was seen in 17 of 45 between native UAE cases and a similar number (38%) cases of HL and was predominately seen of cases diagnosed in expatriates living in the in the MC subtype followed by NS, LD and LR UAE. No differences are found between the two subtypes, respectively. population groups suggesting that environmental factors may play a role in the Clinical chemistry: (Prof. Mukesh M. Agarwal) developing of NHL in the UAE. In the UAE, the prevalence of diabetes mellitus (DM) is the second highest in the world. This The results of some of this work have already remains a major epidemiological challenge for been published in peer-reviewed journals and the country. Multiple studies agree that presented in International pathology and aggressive life-style changes (after delivery) in oncology conferences. women with gestational diabetes (GDM) can delay and even prevent the onset ofType 2 DM. The expression of EBV in Hodgkin lymphoma Much of our research efforts are directed to among UAE nationals was studied in GDM. How to screen a large population in a collaboration with Dr. Suhail Al-Salam (PI), by cost-effective manner? We are continually immunohistochemistry for the latent membrane studying the value of various simple screening tests for GDM, which have a high degree of sensitivity. Ultimately, not missing any pregnant woman with GDM will help us to start prevention for DM, after childbirth. This will help our main objective: to decrease the epidemic ofType 2 DM in the UAE.

Histopathology/lymph node and bone marrow pathology: (Dr. S. M. Chong) The incidence of malignant lymphomas is increasing worldwide. Curiously, however, there are pronounced differences in the incidence of the different types of lymphoma in different parts of the world.

A pilot study has been performed of the differences between lymphoma in the UAE and in Singapore and the findings presented at the 23rd World Congress of Pathology and Laboratory Medicine in Istanbul in May 2005.

In collaboration with Dr. Suhail Al-Salam from the Department and Dr YC Lim of the Department of Pathology of the National University of Singapore, I am studying the role of leukotriene B4 in malignant lymphoma growth and survival; the role of lipid mediators, LTB4 and LXA4 as inflammatory and immune Figure: above, classic binucleated Reed-Sternberg cell in a modulators in Hodgkin lymphoma; and the case of Hodgkin’s disease (arrow) (H & E x 40), below, immunohistochemistry with CD30 antibodies highlights the expression of CD137 on Hodgkin and Non- Reed-Sternberg cells (dark brown color). Hodgkin lymphoma Cells. Dr. Lim and I are also continuing our previous studies on lymphoma cell interactions with endothelial adhesion molecules under flow.

55 Department of Pathology

Histopathology/Lymphoma/Breast aim of our study was to determine the Pathology/CNS pathology/Renal Pathology/ epidemiology of HL inThe population of United Molecular Pathology (Dr. Suhail Al-Salam) Arab Emirates (UAE) nationals, an early industrialized country in the Arabian Gulf, and 1. Expression of EBV in Hodgkin Lymphoma to delineate the extent of its association with among UAE nationals EBV. We review the cases of HL for the period The epidemiology of Hodgkin’s lymphoma (HL) 1988 through 2004 for histological classification shows wide geographic variation in histological and demographic data. All Cases diagnosed as subtypes and in its association with the Epstein- Hodgkin’s lymphoma were examined for the Barr virus (EBV).The proportion of EBV positive presence of EBV using immunohistochemistry HL is low in industrialized countries, high in (IHC) for the latent membrane protein I (LMPI) non-industrialized countries and intermediate and in-situ hybridization (ISH) for EBV encoded in early-industrialized countries. Reports from RNA (EBER) to determine the prevalence of EBV the Arabian Gulf and Middle East are few. The in Hodgkin cells and its possible role in the

Figure: (A) Hodgkin lymphoma with classical Reed–Sternberg cell showing dark-purple nuclear staining for EBER, in situ hybridization, X400. (B) Classical Reed–Sternberg cell showing membranous, cytoplasmic and Golgi immunoreactivity to LMP-1, streptavidin–biotin, X400

pathogenesis of Hodgkin’s lymphoma. EBV was and the most common cancer among females seen in 17 of 45 (38%) cases of HL and was The age specific incidence ratio for females in predominately seen in the MC subtype followed UAE was 19.4 per 100,000 population. It is by NS, LD and LR subtypes, respectively. currently estimated that 5–10% of all breast cancers are hereditary and attributable to 2. Types of mutations in BRCA 1 and BRCA 2 mutations in several high penetrance genes in breast carcinoma among United Arab susceptibility genes, of which only two have Emirates nationals and their correlation with been identified BRCA1 and BRCA2. Earlier P53, Ki 67, bcl2, nm2, c-erb-B2, estrogen receptors estimates suggested that BRCA1 and BRCA2 and progesterone receptors expression. mutations were responsible for 75% of site- Breast carcinoma is the most common specific breast cancer families and the majority malignant tumor and the leading cause of of breast and ovarian cancer families. The aim cancer death in women all over the world. It is of this study is to identify the types of mutations the commonest cancer among UAE population in BRCA 1 and BRCA 2 genes in breast carcinoma 56 Department of Pathology among United Arab Emirates nationals and their carcinomas. We expect that our suggested correlation with the expression P53,Ki studies will clarify and elucidate the role of 67,bcl2,nm2, c-erb-B2, estrogen receptors and galectin 1, 3, 4, 7 and 10 in the pathogenesis and progesterone receptors. progression of human uterine cervical carcinoma. In this project, we will verify this 3. Role of Trefoil Factor Peptides in the hypothesis by extending our experiments on Development and Progression of Glioma. peritumoral stromal mononuclear cells as well Gliomas are the most common primary central as non-neoplastic and dysplastic uterine cervical nervous system tumors. They are the second tissues. most common cancer among children in UAE. They are graded into four grades from grade 1 5. Expression of estrogen receptors alpha which is the most benign to grade 4 which is the and beta and progesterone receptors in most malignant. They are characterized by thyroid carcinoma among UAE Nationals progression from low grade to high grade within Thyroid carcinoma (TC) is the sixth most the same tumor. This progression is not well common cancer among the United Arab understood. Furthermore, the pathogenesis of Emirates (UAE) nationals and the second among glioma is obscure. Several studies have shown UAE national females. The striking gender the transforming potential ofTFF peptides which differences in the incidence of differentiated is illustrated in tissues involved in cancer thyroid cancer, particularly for papillary thyroid progression, while other studies have shown carcinoma (PTC), suggests a possible influence tumor suppressor action of TFF peptides. How of hormone related factors because the higher can the apparent contradiction between the overall incidence of female PTC is established tumor-promoting and tumor-suppressing through a sharp increase during the fertile years functions ofTFF peptides be resolved? We hope of life. We found a high preponderance of that this project will answer some of these differentiated thyroid carcinoma among UAE queries. There is nearly no published data female nationals during the child – bearing age, concerning the expression of TFFs in human which was much higher than expatriates and gliomas. In addition there were no previous other studies else where. We think that this reports concerning the role of trefoil factors in finding suggests a possible hormonal influence the pathogenesis or progression of glioma. Our and needs to be thoroughly investigated. We will preliminary study on few cases of gliomas using review the cases of thyroid carcinoma which immunohistochemical stains have shown were diagnosed in the Pathology Department expression of TFF 3 in gliomas with difference at Tawam Hospital for the period 1988 through in the expression between low grade and high 2007 for histological classification and grade gliomas. demographic data. All cases diagnosed as thyroid carcinoma will be examined for the expression of estrogen receptors alpha and 4. Role of Galectin 1, 3, 4, 7 and 10 in the beta, progesterone receptors, EGFR, c-erb-B2, c- development and progression of uterine kit, cyclin D1, bcl- xL and p53 using cervical carcinoma immunohistochemistry (IHC) as well as Uterine cervical cancer is the second most fluorescent in situ hybridization (FISH) for EGFR, common cancer in women worldwide, and the c-erb-B2 and cyclin D1 to determine the fifth most common cancer among females in frequency of expression of estrogen and UAE. Although high-risk human progesterone receptors in relation to the papillomaviruses (HPVs) are associated with expression of EGFR, c-erb-B2, c-kit, cyclin D1, bcl- cervical carcinoma, HPV infection alone is xL and p53 in different types of thyroid insufficient for the malignant transformation. carcinoma among UAE nationals and in Hence other molecular alterations are required comparison with their expression among for the development of cervical carcinoma and expatriates. This study will enable us to galectins may play an important role in these understand the role of sex steroid hormones processes.The main purpose of this proposal is and various growth factors in the development to study the expression of galectin-1, 3, 4, 7 and of thyroid carcinoma among UAE nationals. 10 in the neoplastic cells of different types, grades and stages of human uterine cervical

57 Department of Pathology

The Genetic and Molecular Basis of Diseases Articles in Peer- prevalent in UAE (Dr. Bassam R. Ali) Current Research Focus: reviewed Journals

1. Identification of the molecular defects Agarwal MM, Dhatt GS, Safraou MF. (2008). Gestational underlying single gene disorders in UAE and diabetes: using a portable Arab populations. Recessive disorders are highly glucometer to simplify the prevalent in Arab populations including UAE approach to screening. mainly due to high levels of consanguinity and Gynecologic and Obstetric lack of prenatal and/or pre-conception diagnosis. Investigation, 66:178-183. We are developing a molecular genetics research Al-Dhaheri WS, Hassouna I, Al- laboratory to look at the molecular defects Salam S, Karam SM. (2008). causing recessive disorders found in the UAE Characterization of breast population with emphasis on mental retardation cancer progression in the rat. phenotypes, metabolic and dysmorphology Ann N Y Acad Sci, 1138:121-31. disorders. We are collaborating with major Al-Ramadi BK, Fernandez- research groups at Harvard Medical School, Cabezudo MJ, El-Hasasna H, Al- University of California in San Diego and Salam S, Attoub S, Xu D, Cambridge University. Chouaib S. (2008). Attenuated bacteria as effectors in cancer immunotherapy. Ann N Y Acad 2. The cellular mechanisms of human Sci, 1138:351-7. monogenic disorders. We are interested in protein trafficking and quality control within Al-Salam S, Alashari M. (2008). eukaryotic cells. The protein quality control at the Expression of Galectin-3, endoplasmic reticulum level is responsible for CD138, P16 INK4a and TTF-1 in Mucinous Bronchioloalveolar the development of several human genetic adenocarcinoma following diseases including cystic fibrosis and Hodgkin's lymphoma. Applied emphysema. We recently elucidated the cellular Immunohistochemistry & mechanisms underlying Robinow syndrome and Molecular Morphology. [ePub Acromesomelic Dysplasia type Maroteaux, 2008] recessive disorders that have been found in Al-Salam S, John A, Daoud S, several parts of the Middle East including Oman Chong SM, Castella A. (2008). and Saudi Arabia. We are currently looking to Expression of Epstein-Barr virus establish the mechanisms underlying Familial in Hodgkin lymphoma in a Hypercholesterolemia, Hereditary Hemorrhagic population of United Arab Emirates nationals. Leuk Telangiectasia and other ER-associated Lymphoma, 49(9):1769-77. degradation diseases. In addition, we are exploring ways of manipulation of ER quality Al-Salam S, Algawi K, Alashari control for potential therapy of such diseases. M. (2008). Malignant Non- Teratoid Medulloepithelioma of ciliary body with Retinoblastic 3. Pharmacogenetics. With Dr. S. Bastaki and differentiation - A case report Prof.Y. Abdulrazzaq, we started establishing the and review of literature. alleles for CYP2D6 gene and other drug Neuropathology, 28(5):551-6. metabolizing enzymes prevalent in UAE population. Al-Salam S, Nowotny N, Sohail M R, Kolodziejek J, Berger T G. (2008). Ecthyma contagiosum Departmental Undertaking: (orf) – report of a human case Drs Alia Al Bawardi and Saeeda Al Marzooqi from the United Arab Emirates (resident trainees) are completing their training and review of the literature. in Pathology at McGill University, Montreal, Cutan Pathol, 35(6):603-7. Canada. Al-Salam S, Al Ashari M, Ghazal- Aswad S. (2008). Expression of

58 Department of Pathology

Insulin-like growth factor-1 the United Arab Emirates. Ann Ali BR, Al-Mazrooei SS, Saadi H, receptors, Wilm's tumor-1 N Y Acad Sci, 1138:108-13. Benedict S, Kazzam E, protein, c-kit and p16 in Khazanehdari KA. (2008). The Primary Fallopian tube Genetic Basis of Familial carcinoma in diabetic patients. k Hypercholesterolemia in the Arch Gynecol Obstet, United Arab Emirates Arab 277(5):449-55. Populations. Proceedings of the 9th UAE University Al-Zaher N, Al-Salam S, El Teraifi Proceedings, Conference, 23-25th April 2008, H. (2008). Thyroid carcinoma Conferences, Al Ain, UAE. in the United Arab Emirates:Perspectives and Invited lectures, Ali BR. (2008). Retention of experience of a tertiary care Web Sites and mutated proteins in the hospital. Hematol Oncol Stem endoplasmic reticulum is a Cell Ther, 1(1): 14-21. Others common mechanism for numerous monogenic diseases. Attoub S, Gaben AM, Al-Salam Abdulrazzaq YM, Ibrahim A, Al- The 2nd Al Ain International S, Al Sultan MA, John A, Nicholls Khayat A, Nagelkerke N, Ali BR. Genetics Conference, Al Ain, MG, Mester J, Petroianu G. (2008). R58fs mutation in HGO UAE. (2008). Captopril as a potential gene in a family with inhibitor of lung tumor growth alkaptonuria in the UAE. The 2nd Al-Mazrooei SS, Karuvantevida and metastasis. Ann N Y Acad Al-Ain International Genetics NS, John A, Akawi NA, Saadi H, Sci, 1138:65-72. Conference, Al Ain, UAE. Khazanehdari KA, Habshi ZH, Ali BR. (2008). The genetic basis Cantagrel V, Silhavy JL, Bielas Agarwal MM. (2008). of familial SL, Swistun D, Marsh SE, Gestational diabetes: using the hypercholesterolemia in the Bertrand JY, Audollent S, Attié- portable glucometer to simplify United Arab Emirates Bitach T, Holden KR, Dobyns WB, the approach to screening. The population. The 2nd Al Ain Traver D, Al-Gazali L, Ali BR, Eighth Annual Research International Genetics Lindner TH, Caspary T, Otto EA, Conference at UAE University, Conference, Al Ain, UAE. Hildebrandt F, Glass IA, Logan Al Ain, UAE. CV, Johnson CA, Bennett C, Al-Zaher N, Al-Salam S (2008). Brancati F; International Al Awadhi AM, Al-Suwaidi S, Thyroid Nodules and Joubert Syndrome Related John A, Hume AN, Al Gazali L, Malignancies, the Road from Disorders Study Group, Valente Bader M, Ali BR. (2008). the Needle Aspiration to EM, Woods C G, Gleeson JG Defective cellular trafficking of Treatment Completion. The (2008). Mutations in the cilia NPR-B is the major mechanism Sixth Annual Middle East gene ARL13B lead to the underlying Acromesomelic Update in Otolaryngology - classical form of Joubert Dysplasia type Maroteaux. The Head and Neck Surgery, 1-3 syndrome. Am. J. Hum. Genet., 2nd Al Ain International April 2008. 83, 170-179. Genetics Conference, Al Ain, UAE. Attoub S, Al-Salam S, John A, Denic S, Nagelkerke N, Agarwal Manjush S, Al Sultan M, Al Safi MM. (2008). Consanguineous Al-Gazali L, Akawi NA , Shather B, M, Raza H, Adem A. (2008). marriages and endemic malaria: Kaplan W, Algawi K, Ali BR. (2008). Thymoquinone induces human can inbreeding increase Anterior segment anomalies of the cancer cell death and tumor population fitness? Malaria eye, growth retardation associated growth inhibition. 9th UAE Journal, 7:150. with hypoplastic pituitary gland University research conference. and endocrine abnormalities: Jung 23-25th April 2008, Al Ain, UAE. Denic S, Nagelkerke N, Agarwal Syndrome or a new syndrome? MM. (2008). Consanguineous The 2nd Al Ain International John A, Hertecant J, Al-Gazali marriages: do genetic benefits Genetics Conference, Al Ain, UAE. L, Karuvantevida NS, Ali BR. outweigh its costs in (2008). Identification of a novel populations with a+- Ali BR. (2008). Cellular mutation in ARG1 gene thalassemia, hemoglobin S, and organelle disease genomics: responsible for arginase malaria? Evolution and Human retention of mutated proteins deficiency in an Asian family Behavior 29: 364-369. in the endoplasmic reticulum from United Arab Emirates. The is a common mechanism for 2nd Al Ain International Faour I, Al-Salam S, El-Terifi H, El numerous monogenic diseases. Genetics Conference, Al Ain, Taji H. (2008). The use of a The 4th EMBO Conference: UAE. vacuum-assisted biopsy device From Functional Genomics to Karuvantevida NS, Al-Mazrooei (Mammotome) in the early System Biology, Heidelberg, SS, John A, Hume AN, Al-Allaf detection of breast cancer in Germany. F, Ali BR. (2008). The Cellular

59 Department of Pathology

Basis of Familial Hypercholesterolemia. The 2nd Al Ain International Genetics Conference, Al Ain, UAE.

Lin JHR, Chong SM, Lim YC. (2008). E-selectin-B cell interactions under defined flow conditions is mediated by L- selectin & ‚1-integrin. NHG Annual Scientific Congress, Singapore. k

Research Grants

FMHS New Research Grant 2008 Prof MM Agarwal [PI], Drs G Dhatt, N Bali. Gestational diabetes mellitus: value of serum fructosamine as a screening test.

Dr BR Ali [PI], Prof L Al-Gazali. Establishing mammalian cell lines expressing ERAD substrates for evaluating ER quality control escape as a therapeutic target for genetic diseases.

Dr S Al-Salam [PI]. Role of Galectin 1, 3, 4, 7 and 10 in the development and progression of uterine cervical carcinoma.

UAEU Individual Grant 2008

Dr S Al-Salam [PI]. Expression of estrogen receptors alpha and beta and progesterone receptors in thyroid carcinoma among UAE Nationals and their relation with the expression of EGFR, c-erb-B2, c-kit, cyclin D1, bcl- xL and p53.

National Research Foundation Dr Ali BR, Prof L. Al-Gazali [PI], Dr O El-Agnaf, Profs TE Adrian, E Adeghate, B al-Ramadi. Genes and Diseases Research Center of Excellence.

60 Department of Pathology

Standing lef to right: Dr Bassam Ali, Dr Suhail Al Salam, Dr Antonio Castella, Prof Mukesh Agarwal, Dr Chong Siew Meng. Seatted lef to right: Mr Noushad, Ms Anne Mathew, Ms Manjusha Sudhadevi, Ms Khaula Al Ghanem 2008Pathology

http://www.fmhs.uaeu.ac.ae/Departments/Pathology Tel: 7672000 / Fax: 7671966

61 Department of Pharmacology

Research Profile

Professor & Chair: The Pharmacology Department has special Prof G Petroianu interests in Diabetes and Degenerative Professor: Prof A Adem Diseases, Neuroscience, Clinical Toxicology, Prof MY Hasan Gastroenterology and Oncology. The research is Associate Professor: done with state of the art equipment in purpose- Dr S Bastaki Dr M Oz built laboratories with good technical and other Assistant Professor: support. Dr S Attoub Medical Research Specialist: Prof. Abdu Adem Ms N Amir Diabetes Ms K Arafat Mechanisms of Apoptotic Cell Death in Diabetes Mr SM Nurulain In almost all multicellular organisms, cell suicide or apoptosis Mr A Shamsllisam appears to play an important role in the maintenance of cellular Medical Secretary: homeostasis. Apoptosis is tightly regulated by a set of genes that Ms S Duncan either promote apoptosis or promote cell survival. Although a number of stimuli appear to trigger the process of apoptosis, Central Facilities there are two major signaling pathways of apoptosis: the death Medical Research receptor pathway and the death receptor-independent or Specialist: mitochondrial pathway. Mechanisms of apoptotic cell death are Dr M Kosanovic being studied in kidneys of an animal model of diabetes.The ultra structural features in the tubules seem to implicate apoptosis in Animal House the pathology of renal nephropathy. In addition we reported, for Veterinarian: the first time, a significant loss of foot processes of podocytes Dr M Al Sultan (*) in the diabetic rat kidney (Fig.1 left). These findings could Medical Research contribute to the understanding of the patho-physiology of Specialist: diabetic nephropathy. Mr M El Wasila Mr M Shafiullah Neurodegenerative Diseases Novel Selective Ligands for Muscarinic Acetylcholine Receptors Five muscarinic acetylcholine receptor subtypes (M1- M5) have been cloned and are found in the brain. However, the pharmacological identification of the subtypes responsible for the various central effects of the muscarinic drugs is difficult due to the lack of highly selective muscarinic agonists and antagonists. We have isolated muscarinic M1 and M4 receptor Department of Pharmacology subtype selective toxins from mamba snake properties are tested in conjunction with (Dendroaspis) venoms. At present the status of benzamides to increase survival in exposed M1 and M4 receptors in health and disease animals. states in humans are being investigated. Our results show significant decrease of M4, but not Prof. MY Hasan of M1 receptors in the hippocampus of Neuroscience Alzheimer’s patients compared to controls. The main line of research has been focusing on Moreover, changes in these receptors in neurotransmission. We have been applying adrenalectomized animal models which have behavioral, biochemical and electro- been shown to have a selective loss of physiological and morphological techniques in hippocampal neurons. Attempts to isolate and understanding the role of neurotransmitters in characterize M2, M3, and M5 selective toxins is various disorders (diabetes, epilepsy, aging, also in progress. Behavioral, biochemical and neurodegenerative diseases). Findings indicated electrophysiological techniques are also used in significant modification of specific understanding the role of other neurotransmitters in many of the disorders. It neurotransmitters in diabetes, epilepsy, appears that alteration in calcium mobilization aggressive behavior, aging, and degenerative and free radical system may be a common factor diseases. accounting for some of the changes observed in aging, diabetes and Parkinson's disease. Prof. Georg Petroianu Another line of research has been toxicological Clinical toxicology studies and impact of toxins on muscle the Therapy of acute organophosphate nervous system. We have investigated the effects poisoning of heavy metal intoxication in relation to Organophosphorus cholinesterase inhibitors (organophosphates) are widely used in agriculture, in industry and technology, and in military technology. According to the WHO, more than one million casualties per year are due to organophosphates exposure. Countries of the Indian subcontinent and adjacent regions top the list. While use of atropine in the therapy of acute organophosphate poisoning is well- established clinical practice, the use of oxime enzyme reactivators (pralidoxime, obidoxime) is a hotly debated issue. Recent in vivo data from our laboratory shows that oximes produce a spurious signal when ChE activity is determined photometrically. True enzyme FIGURE 1 protection/reactivation is thus less than assumed. Furthermore high dose oxime increases the “time-to-extubation (TTE)” and mortality as compared to identical therapy degenerative diseases. We studied impact of without oxime (animal data). The paradigm of heavy metal toxicity on nervous system and enzyme reactivation in organophosphate muscle and observed that free radicals may be poisoning must be reassessed and alternatives involved in metal toxicity and antioxidants like developed. Screening of benzamide ascorbic acid and alpha-tocopherol may have a compounds with cholinesterase protective protective role against metals effects Also we capabilities is a present priority of our group. have been looking at neurotoxicity and general Preliminary experiments performed in our toxicity from organophosphates and nerve laboratory in vitro and in vivo suggest that the gases. We have been screening antidotes for benzamide compound tiapride is partially organophosphate poisoning and implication protective against esterase inhibition by for treating exposure to nerve gas agents. organophosphates. In addition newly Furthermore my interest covered broad areas in synthesized oximes with superior reactivating medical education and community health. Some

63 Department of Pharmacology

of the projects performed included; drug polymorphic and numerous mutant CYP2D6 utilization and rational use of antibiotics and alleles are currently known including defective analgesics in health care centers and alleles which yield no functional protein product community, developing Sickness Impact Profile and duplicated active alleles which cause for studying quality of life in infertile patients, ultrarapid oxidation. Two CYP2D6 oxidation studying views of medical students and phenotypes EM (extensive metabolisers) and PM physicians of clinical skills teaching at the (poor metabolisers) are commonly recognized. medical colleges and surveying patient’s These phenotypes can be accurately predicted attitudes towards students involvement in by genotyping. The clinical implications of the medical practice. CYP2D6 polymorphism are of potential importance to psychiatric practice in the UAE Dr. Salim Bastaki since tricyclic antidepressants are widely Gastroenterology: Gastrointestinal diseases prescribed for treatment of depression. These have increased in recent years. Work stress, drugs have a small therapeutic index and alcohol, non-steroidal anti-inflammatory drugs unpleasant side-effects or therapeutic failure is (NSAIDS) strong tea or coffees have contributed commonly encountered when fixed dose to the pathology. Our research is based on regimens are used. There are only very few and gastrointestinal secretion and the mechanism conflicting data concerning the distribution of of action of PPIs and other acid inhibitors on acid CYP2D6 phenotypes in Arab populations and no secretion. In the early years, Histamine H2- genotyping studies have ever been carried out. receptor antagonist, Sucralfate and Muscarinic We aim to determine the frequency of the most receptor antagonists were used more often. common CYP2D6 alleles in the local population But with the introduction of the proton pump using allele specific PCR methodology and to inhibitors (PPIs) their use has declined owing assess the relevance of the CYP2D6 to the potent anti-secretory and anti-ulcer polymorphism to psychiatric practice in the UAE. activity of the PPIs. Recently we published the work on new proton pump inhibitor, Dr. Murat Ahmed Oz esomeprazole, Astra-Zeneca (accepted for Research interest of Dr. Oz focuses on the publication [2008]). At present we are studying identification of ion channels and neuronal the interactions of aspirin in combination with networks upon which neuropharmacologically ibuprofen on gastric acid and ulcer formation in active agents act to modulate neuronal the rat in vivo and in vitro (manuscript in excitability.To this end, actions of neuropeptides preparation). In the near future we are planning such as vasopressin, angiotensin, and to study the effect of stress on the mucosa of FSL cholecystokinin on the spinal cord preparations and FRL rats and the healing rate of alcohol-and and the effects of bioactive lipids such as indomethacin-induced ulcers in the same rats. endocannabinoids on the functions of ion Teratology: Epilepsy affects approximately 1% of channels are the major research topics the world’s population and it is the second most investigated in his laboratory. common neurologic disorder after stroke. It is a heterogeneous symptom complex a chronic Dr. Samir Attoub disorder characterized by chronic seizures. Cancer research Approximately 0.5% of all pregnancies occur in My research is focused on the role of women with epilepsy. It is known that epileptic PI3K/Akt/NFKB‚ pathway as a driving force behind women demonstrate a higher liability to obstetric lung and colon cancer progression (apoptosis, complication than non-epileptic females and invasion, angiogenesis and metastasis) using congenital malformations are more common in siRNA technology and in parallel screening of their offspring than those of women who do not potential anti-cancer drugs. take anti-epileptic drugs. Pharmacogenetics: Oxidation by enzymes 1. Identification of Akt isoforms involved in encoded at the CYP2D6 locus is the main route colon cancer survival and invasion of elimination for a large number of drugs The PI3K/Akt/NFKB signaling cascade is including many commonly prescribed in constitutively activated in cancers. Akt is linked psychiatric practice such as antidepressants and to the transforming activity of c-src, c-kit, c-met neuroleptics. The CYP2D6 locus is highly oncogenes and growth factors, such as EGF and

64 Department of Pharmacology

IGF receptors. Drugs targeting receptor tyrosine using microarray analysis and confirm the results kinases (ErbB2/HER2 and ABL/c-kit) impact the by real-time RT-PCR. It is anticipated that this PI3K/Akt pathway. Consequently, the inhibition project will provide evidence that targeting of Akt is considered to be an attractive cancer Akt-1 and/or -2 is a promising strategy for the therapeutic target. Three isoforms of Akt treatment of colon and lung cancer. (Akt1/PKB·, Akt2/PKB‚, and Akt3/PKBÁ) are over- expressed and activated in cancers, but the 2. Screening of potential anti-cancer degree of functional redundancy between them compounds using in vitro and in vivo assays on cancer cell survival and invasion are unclear. The overall goals of this part of my research are The identification of the Akt isoform that is the directed towards studying the in vitro and in vivo most promising target for cancer therapy is cytotoxic properties of the synthesized/purified unknown and will be addressed in the following drugs (Luteolin,Thymoquinone and Frondoside specific objectives: A). The effective drugs will be further investigated in order to determine their a. To explore the respective roles of Akt-1, -2 mechanisms of action using various molecular and -3 in cancer cell survival, invasion, tumor biological techniques. In addition, we will growth and metastasis, studies will be attempt to investigate the effects of these drugs conducted using RNA interference technology on cell survival and invasion in vitro and on in LNM35 human lung cancer cells and HT29 tumor growth in vivo.The effects on metastasis human colon cancer cells. in nude mice using various cancer cell lines will also be investigated. b.To characterize the ability of different isoforms of Akt (Akt-1, -2 and -3) to transactivate different subsets of target genes to orchestrate either cell survival or invasion.This will be investigated in colon and lung cancer cells using microarray analysis.

The effects of knockdown of Akt-1, -2 or -3 on cellular survival will be determined by cellular viability, DNA fragmentation, cell cycle and TUNEL assays, caspases activity, PARP cleavage, cytochrome-c release and expression of pro- and anti- apoptotic proteins.The impact of Akt- 1, -2 or -3 silencing on invasion will be investigated using the collagen type I and the chick heart invasion assays, cell-cell and cell- matrix adhesion and expression of E-Cadherin. The effect of knock down of the Akt’s on HT29 cell line on tumour growth will be tested in nude mice. In addition, we will assess the development of new blood vessels (CD31 antibody), the presence of apoptotic cells (caspase 3 activity), and proliferative activity (ki67 antibody). We’ll test the therapeutic impact of the Akt isoforms inhibition on metastasis using the highly invasive and metastatic lung cancer cell line LNM35 targeting the lymph nodes and lungs. This cell line is stably transfected with a vector encoding luciferase, to allow a rapid and reliable quantification of micro-metastases. To identify the mechanisms underlying the effects of Akt isoform inhibition, we will search for differentially expressed genes

65 Department of Pharmacology

Chang M, Sun XJ, Adem A, Lorke DE, Nurulain SM, Hasan MY, Articles in Peer- Winblad B, Zhu J.(2008).The role Kuca K, Musilek K, Petroianu GA. reviewed Journals of IL-12 and TNF-alpha in AIDP (2008). Eight new bispyridinium and AMAN. Eur J Neurol. 15; 1100- oximes in comparison with the 5. conventional oximes pralidoxime and obidoxime: in vivo efficacy Abdulrazzaq YM, Osman N, Fernandez-Cabezudo MJ, to protect from Nagelkerke N, Kosanovic M, Adem Azimullah S, Nurulain SM, diisopropylfluorophosphate A. (2008). Trace element Mechkarska M, Lorke DE, Hasan toxicity. J Appl Toxicol. 28; 920-8. composition of plasma and breast MY, Petroianu GA, Al-Ramadi BK. milk of well-nourished women. J (2008). The organophosphate Lu MO, Zhang XM, Mix E, Quezada Environ Sci Health. A43 (5); 329- paraoxon has no demonstrable HC, Jin T, Zhu J, Adem A.(2008). 34. effect on the murine immune TNF-alpha receptor 1 deficiency system following subchronic low enhances kainic acid-induced Al-Ramadi BK, Fernandez- dose exposure. Int J hippocampal injury in mice. J Cabezudo MJ, El-Hasasna H, Al- Immunopathol Pharmacol. 21; Neurosci Res. 5;1608-14. Salam S, Attoub S, Xu D, Chouaib 891-901. S.(2008). Attenuated bacteria as Padmanabhan R, Abdulrazzaq YM, effectors in cancer Jackson SN, Singhal SK, Woods Bastaki SM, Shafiullah MM. (2008). immunotherapy. Ann N Y Acad AS, Morales M, Shippenberg T, Intrauterine growth restriction Sci. 1138; 351-7. Zhang L, Oz M.(2008). Volatile and skeletal variations in mouse anesthetics and endogenous fetuses induced by vigabatrin Attoub S, De Wever O, Bruyneel cannabinoid anandamide have administered at preimplantation E, Mareel M, Gespach C. (2008). additive and independent stages of development. Congenit The transforming functions of PI3- inhibitory effects on alpha(7)- Anom (Kyoto). 48; 29-39. kinase-gamma are linked to nicotinic acetylcholine receptor- disruption of intercellular mediated responses in Xenopus Petroianu GA. (2008). The history adhesion and promotion of oocytes. Eur J Pharmacol. 17; 42- of cholinesterase inhibitors: who cancer cell invasion. Ann N Y Acad 51. was Moschnin(e)? Pharmazie. 63; Sci. 1138: 204-13. 325-7. Lorke DE, Hasan MY, Arafat K, Kuca Attoub S, Gaben AM, Al-Salam S, K, Musilek K, Schmitt A, Petroianu R Padmanabhan, YM Abdulrazzaq, Al Sultan MA, John A, Nicholls MG, GA.(2008). In vitro oxime SMA Bastaki, M Shafiullah, SI Mester J, Petroianu G. (2008). protection of human red blood Chandranath. (2008). Captopril as a potential inhibitor cell acetylcholinesterase inhibited Experimental Studies on of lung tumor growth and by diisopropyl-fluorophosphate. Reproductive Toxicologic Effects metastasis. Ann N Y Acad Sci. J Appl Toxicol. 28: 422-9. of Lamotrigine in mice. 1138; 65-72. Congenital Abnorm, 48: 29-39. Lorke DE, Hasan MY, Nurulain SM, Bastaki SM, Chandranath IS, Singh Kuca K, Schmitt A, Petroianu GA. Siddig A, Mohamed AO, Awad S, J. (2008). The anti-secretory and (2008). Efficacy of two new Hassan AH, Zilahi E, Al-Haj M, anti-ulcer activities of asymmetric bispyridinium oximes Bernsen R, Adem A. (2008). esomeprazole in comparison with (K-27 and K-48) in rats exposed Estrogen receptor alpha gene omeprazole in the stomach of rats to diisopropylfluorophosphate: polymorphism and breast cancer. and rabbits. Mol Cell Biochem. comparison with pralidoxime, Ann N Y Acad Sci. 1138; 95-107. 309; 167-75. obidoxime, trimedoxime, methoxime, and HI-6. Clin Toxicol Siddig A, Mohamed AO, Kamal H, Butt C, Alptekin A, Shippenberg T, (Phila). 23; 1-7. Awad S, Hassan AH, Zilahi E, Al-Haj Oz M (2008). Endogenous M, Bernsen R, Adem A. (2008). cannabinoid anandamide inhibits Lorke DE, Hasan MY, Nurulain SM, HER-2/neu Ile655Val nicotinic acetylcholine receptor Shafiullah M, Nagelkerke N, polymorphism and the risk of function in mouse thalamic Petroianu GA. (2008). Effect of breast cancer. Ann N Y Acad Sci. synaptosomes. J Neurochem. 105; intrathecal pralidoxime 1138: 84-94. 1235-43. administration upon survival of rats exposed to the Stegmeier-Petroianu A, Petroianu Csermely T, Kalász H, Petroianu organophosphate paraoxon. GA. (2008). Hiccups and GA, Kuca K, Darvas F, Ludányi K, Neurotoxicology. 29; 663-70. dopamine. Am J Health Syst Mudhafar AA, Tekes K. (2008). Pharm. 15; 2092-4. Analysis of pyridinium aldoximes Lorke DE, Kalasz H, Petroianu GA, - a chromatographic approach. Tekes K. (2008). Entry of oximes Curr Med Chem. 15; 2401-18. into the brain: a review. Curr Med k Chem. 15; 743-53. Deng H, Yang X, Jin T, Wu J, Hu LS,

66 Department of Pharmacology

Manjusha S, Al Sultan MAH, Al Safi to Channelopathies, 25 Years of Books, Chapters, MM, John A, Raza H, Adem A. Research Advanced Workshop in Reviews and (2008). Thymoquinone induces Kyiv, Ukraine, June 2008. human cancer cell death and Editorials tumor growth inhibition. The 9th Oz M. (2008). Ion Current UAEU Annual Research Measurements Using Patch-Clamp Petroianu GA, Lorke DE. (2008). Conference, Al-Ain, United Arab Technique, 2nd International Pyridinium oxime reactivators of Emirates, April 2008 Congress on Cell Membranes and cholinesterase inhibited by Oxidative Stress Focus on Calcium diisopropyl-fluorophosphate Attoub S. (2008). Selective Signaling and TRP Channels in (DFP): Predictive value of in-vitro depletion of Akt-1 and -2 uncover Isparta, Turkey. testing for In-Vivo efficacy. Mini their respective contribution to Rev Med Chem. 8; 1328-42. colon and lung cancer progression Oz M, Jaligam V, Shippenberg, TS. AACR International Conference on (2008). The endogenous "Advances in Cancer Research: cannabinoid anandamide inhibits k From the Laboratory to the Clinic". dopamine transporter function Dead Sea, Jordan, March 2008. and cell surface expression. Soc. for Neurosci. Proceedings, MY Hasan, GP Petroianu, Al Junaibi Conferences, F, Al Ahbabi F, Al Kuwaiti N, Al Petroianu G. (2008). Maamari S, A Adem, M Fahim, Neuropharmacology review: The Invited lectures, Praquat exposure induces Newer AEDs Web Sites and alterations in brain 9th Cairo International Neurology catecholamines: Implications for Conference. The Egyptian Society Others. Parkinson’s disease ?The 9th UAEU of Neurology Psychiatry & UAEU Annual Research Neurosurgery, Cairo, Egypt. Adem A, Lu MO, Zhang XM, Mix E, Conference, Al Ain, United Arab Quezada HC, JinT, Zhu J.TNF alpha Emirates. (2008) Petroianu G. (2008). receptor 1 deficiency enhances Antihistaminika aus kainic acid induced hippocampal Bastaki MA, Adeghate E, pharmakologischer Sicht. 5th HNO injury in mice. 6th FENS, Forum of Chandranath I, Tariq S, Adem A. Symposium. St. Joseph-Stift, European Neuroscience, Geneva, (2008). Evaluation of the Bremen, Germany. Switzerland, July 12-16, 2008. morphological changes in the glandular stomach of Prévost GP, Damian M, Attoub S, A Adem, M. Al Haj, I. S. streptozotocin-induced long-term Ayoub M.A, Pin J.P, Banères J-L, Chandranath, E. Kazzam, E. diabetic rats. The United European Petit M, Depierre G, De Giorgi F, Obineche. Effect of Long-term gastroenterology Week in Vienna, Brezak M-C, Coulomb H, Dehydration on Hormones in the Austria. Chaumeron S, Ferrandis E, Roubert One-humped Camel.The 9th UAEU P, Demarquay D, Lavergne O, UAEU Annual Research El-Hasasna H, Fernandez- Thurieau C, Ichas ¬F,Silvente-Poirot Conference, Al Ain, United Arab Cabezudo MJ, Al-Salam S, Bashir G, S, Favre G, Poirot M, Carlson M, De Emirates. (2008) Attoub S, Chouaib S , al-Ramadi Wever O, Geiseler F, Gespach C & BK. (2008).The anti-tumor activity Kasprzyk P. (2008). Blocking Attoub S, Al-Salam S, John A, of systemically-administered IL2- heterotrimeric G-protein complex Manjush S, Al Sultan M, Al Safi MM, expressing salmonella correlates by a small-molecule inhibitor as a John A, Raza H, Adem A. (2008). with decreased angiogenesis and potential therapy for human Thymoquinone induces human enhanced apoptosis. 3rd Al-Ain tumors. 99th AACR Annual cancer cell death and tumor International Immunology Meeting, San Diego, California, USA. growth inhibition. AACR Meeting, Al-Ain, UAE. International Conference on "Advances in Cancer Research: Fernandez Cabezudo MJ, Ullah A, k From the Laboratory to the Clinic". Nurulain SM, AlRamadi BK, Dead Sea, Jordan. Petroianu GA. (2008). Assessment of immunologic parameters Attoub S, Al-Salam S, John A, following exposure to Research Grants Manjush S, Al Sultan M, Gaben AM, organophosphate containing John A, Raza H, Adem A. (2008). pesticides. Al Ain International Thymoquinone induces human Immunology Meeting. cancer cell death and tumor FMHS Research grant growth inhibition. EUROCANCER, Oz M. (2008). Voltage-gated Paris, France. Prof A Adem [PI] calcium channels are novel targets Immunological responses in brain for endocannabinoids T-type after adrenalectomy. Attoub S, Al-Salam S, John A, Calcium Channels: from Discovery

67 Department of Pharmacology

Dr S Attoub [PI] in the UAE. (07/148). pathogenesis of excitotoxic Effect of Frondoside A on tumour neurodegeneration: a model of cell survival and invasion in vitro FMHS Seed Grant Alzheimer’s disease. 2008 and in vivo. Dr M Oz [PI] UAEU Individual Grant Arachidonic Acid Modulation of Others Serotonin Type Three Receptors Dr S Bastaki.The protective effects Prof A [PI] Expressed in Xenopus Oocytes. of omeprazole (or Role of inflammatory molecules UAEU Interdisciplinary Grant Lansoprazole)/ranitidine/CCK-B and their receptors in Prof A Adem. Enhancement of receptor antagonists on adrenalectomy. Solubility, Stability, Dissolution aspirin/NSAID/stress-induced Rate, and Bioavailability of Poorly ulcer in Flinder rats. Dr S Attoub [PI] Water-soluble Antifungal Drugs Investigation of Luteolin as a by Complexation with potential inhibitor of cell survival Cyclodextrins. (PI: Dr. Ali Al- k and tumour growth. Marzouqi).

Dr S. Bastaki. [PI]The occurrence of Sheikh Hamdan Award mutant alleles at the CYP2D6 gene Prof A Adem. Potential role of locus in UAE Nationals and its immune response and implication for Psychiatric practice inflammatory molecules in

Standing left to right: Mr C Saeed, Prof A Adem, Dr M Al Sultan, Mr Azim, Mr M Elwasila, Dr S Attoub, Dr. Murat Oz, Dr Huba, Mr SM Nurulain Seated left to right: Ms Sumia, Ms Naheed, Ms S Duncan, Prof M Y Hasan, Prof G Petroianu, Dr M Kosanovic, 2008PharmacologyMs K Arafat and Dr S Bastaki.

http://www.fmhs.uaeu.ac.ae/Departments/Pharmacology Tel : 7672000 / Fax : 7672033

68 Department of Physiology

Research Profile

Members of Staff of the Physiology Department Professor & Chair: have interests in neuroscience and muscle Prof TE Adrian Professor: (including skeletal, cardiac and smooth muscle). Prof M Fahim The experimental work includes normal Prof W Lammers physiology as well as pathophysiology, particularly Prof M Ljubisavijevic Prof FC Howarth in relation to the peripheral nerves, autonomic Prof J Morrison nervous system, and heart in the diabetic state, Associate Professor: which is a common disorder in the United Arab Dr A Nemmar Medical Research Emirates. The work requires complex Specialist: electrophysiological and cellular methodologies, Mr S Dhanasekaran as well as electron microscopy, using in vitro and Ms K Parekh Mr MA Qureshi in vivo techniques. Other departmental research Ms B Stephen interests include uterine smooth muscle Ms Shaheen Zia physiology, cardiovascular and pulmonary effects Research Assistant: Ms Sneha Ann Thomas of particulate air pollution and cancer biology. Secretary: Mr P Rajagopalan Office Assistant: Mr Saeed Aging and neurodegenerative disorders Studies on aging and neurodegenerative disorders have focused on synaptic plasticity and synaptic remodelling, particularly at the nerve-muscle junction in various peripheral neuropathies including those caused by diabetes, aging and heavy metal poisoning. Electrophysiological, laser confocal microscopy and electronmicroscopy techniques are used in combination to focus on changes in muscular performance in these conditions. It is hypothesised that free radicals are involved in these nerve injuries and antioxidants like vitamin E & C may have a protective role. Studies on the cerebral microcirculation include changes in the susceptibilty to thrombus formation in the brain, and the effects of metals, aspirin and heat. Department of Physiology

Electrophysiology and clinical exercise and fatigue. The work focuses on neurophysiology laboratories mechanisms associated with sensorimotor The research activities of the electrophysiology integration and maladaptive plasticity in central laboratory focuses on skeletal muscle function fatigue. In collaboration with colleagues from and muscle pain.The main techniques employed the Institute for Neurology, University Clinical are classical electrophysiological techniques Center Belgrade, we are investigating the (EMG, ENG, muscle force and velocity, single character of pathophysiological maladaptive fiber and single unit-extracellular/intracellular cortical processes in Parkinson’s dystonia and recordings). We have also recently introduced tremor. Finally, in collaboration with neurology at FMHS the set of small animal behavioral division and ENT department of Tawam Johns techniques including Morris Water Maze,T and Hopkins Hospital we are currently developing Y maze, coordination and balance motor testing a set of clinical experimental and therapeutic etc. We are also planning to introduce multiunit TMS protocols for Multiple Sclerosis, stroke and recording by implementing multisite cell chronic idiopathic tinnitus patients. recordings in order to investigate in more details the plasticity changes of spinal cord pain Mapping laboratory processing neural networks. We are particularly As in previous years, work has steadily interested to elucidate differences between progressed in the mapping laboratory. A major cervical and spinal neural networks as they may achievement this year has been that we finalized exhibit differential processing in chronic muscle and published a study on the patterns of pain conditions which are clinically quite electrical propagations in the whole intact and different in these two regions. isolated small intestine, describing and explaining the well-known contraction The newly formed clinical neurophysiology frequency gradient in this organ. Another laboratory uses Transcranial Magnetic milestone was the publication of the mechanism Stimulation (TMS) and other classical clinical of rhythm disturbances (arrhythmias) in the neurophysiology methods (H and F wave, stomach. The recordings had been performed Evoked potentials) to investigate mechanisms in the research laboratories of Johnson & of human nervous system plasticity and the Johnson in Beerse, Belgium and the analysis possibilities to remodel these processes in performed in Al Ain. healthy subjects and several diseases primarily focusing on movement disorders. Dr. More collaborations were initiated or expanded Ljubisavljevic’s special interests over the years and visits were made to several laboratories were cortical processes related to volition in including the Arbeitsgruppe Enterisches

70 Department of Physiology

Nervensystem Kinderchirurgie in Zweibrucken, In the UAE, research collaboration has developed Germany (January 2008; motility mapping of with Dr Sandeep Subramanya, Assistant neonatal rat small intestine seeded with stem Professor, department of Physiology, RAK cells, Professor H Schafer), the Division of Medical School, to study the effects of cholera Cardiovascular and Endocrine Sciences, University toxin on the electrical and mechanical activities of Manchester, in Manchester, UK (July 2008, in the rat small intestine, a project for which electrical mapping of the knock-out murine SA- we have also submitted together a Hamdan node, Dr Ming) and the Bioengineering Laboratory, grant. At FMHS, a collaborative project is Auckland University, Auckland NZ (December ongoing with Dr Fayez Hammad investigating 2008; electrical mapping of the porcine and the the acute and long-term effects of permanent human stomach; Professors Pullan, Cheng and or reversible unilateral ureter obstruction on Windsor). The laboratory also hosted one visitor the electrical activity proximal and distal to the last November; Professor Jan Huizinga, Director of obstruction, with a first presentation expected the Farncombe Family Intestinal Health Research in Stockholm in March 2009 Institute, McMaster University, Hamilton, Canada who gave a talk to the faculty.

Figure: Slow wave propagation during irregular tachygastria. Upper traces display continuous variations in waveform amplitudes and directions. Four periods (A-D) were selected and the corresponding maps presented in the lower panels. Map A shows a large waveform originating from the distal antrum propagating retrogradely, and colliding with a second slow wave descending from the corpus. Map B shows again a slow wave with a distal antral origin and two premature waves originating simultaneously close to the corpus (blue isochrone). These three waveforms then merged in the middle of the antrum. Map C: shows two waveforms, one propagating close to the lesser curvature and another one propagating close to the greater curvature; they collided with each other in the distal antrum. In map D, a re-entrant wave (red isochrone; t = 34.0 seconds), revolved as a large counter clockwise loop in the middle of the antrum. Lower inset: location of the 240-mapping electrode system on the stomach (Lammers et al, Gastroenterology 135, 1601-1611, 2008).

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The cancer laboratory novel growth-related genes from their expressed The overall thrust of the pancreatic cancer sequence tags and this has led to the discovery program is elucidating the molecular of a new tumor suppressor gene in the mechanisms underlying its rapid growth and endoplasmic reticulum. invasion and in developing novel strategies to treat it. Prof. Adrian investigates various aspects Recently we have shown that the gene for the of this pancreatic cancer, including growth and BLT2 leukotriene receptor is switched on in all differentiation signaling pathways, the role of pancreatic intraepithelial neoplasias (PanIN the lipoxygenase pathways in tumor growth lesions), which are the precursor lesions for and escape from apoptosis, the interactions pancreatic cancer. The BLT2 receptor is also between pancreatic cancer cells and the upregulated in pancreatic cancer tissues. pancreatic endocrine islet tissue, as well as the Overexpression of these BLT2 receptors provides reasons for the severe metabolic disturbance a growth advantage compared with the wild and cachexia that accompany this devastating type cells, while knockdown of overexpression disease. With his collaborators, he has developed using siRNA causes growth inhibition. These some novel therapeutic agents, one of which findings suggest that the BLT2 receptor would recently entered clinical trials. New anti-cancer be valuable target for chemoprevention or compounds have been isolated from marine therapy of pancreatic cancer. organisms, including the sea cucumber. The mechanisms by which these agents cause cell In other studies we have shown that the sea cycle arrest and induce apoptosis in cancer cells cucumber-derived triterpene glycoside, are currently under investigation. Recently, he frondoside A causes marked growth inhibition has used oligonucleotide microarrays to identify of human pancreatic cancer cells, both in vitro

Immunohistochemical localization of BLT2 in human pancreatic tissues stained by the AP-Red system. Pictures include an unstained duct in normal pancreas; a PanIN-3 lesion with intense cytoplasmic staining; infiltrating tumor cells in a pancreatic cancer with marked positive staining in the cytoplasm; positive stained tumor cells in a lymph node metastasis (all x400);

72 Department of Physiology and in vivo. Frondoside A causes apoptosis of the investigated the translocation of inhaled ultrafine cancer cells via the mitochondrial pathway. pollutant particles in humans and hamsters, and New studies on the 5-lipoxygenase (5-LOX) the mechanisms of their acute cardiopulmonary pathway have focused on colonic cancer. 5-LOX effects. Dr Nemmar intends to further clarify the expression was detected in all adenomatous acute and chronic cardiopulmonary effects of colonic polyps that were studied but not in pollutant particles, and to develop normal colonic mucosa or in hyperplastic polyps. pharmacological approaches capable of These adenomas are the precursor lesions for preventing particle-induced cardiorespiratory human colonic cancer. Inhibitors of the 5-LOX complications. Moreover, epidemiological pathway block growth of colonic cancer cells in studies indicate that the effects of air pollution vitro and also when transplanted into athymic are more pronounced in“susceptible”subjects, mice. These important findings suggest that 5- such as the elderly, diabetics or hypertensive. Dr LOX inhibitors may be valuable in the Nemmar will verify this hypothesis by extending chemoprevention of colonic cancer in humans. his experiments in a relevant animal model of enhanced susceptibility (spontaneously hypertensive and diabetic animals). Pathophysiologic mechanisms of particulate air pollution The main research topic of Dr Nemmar is related Diabetic Neuropathy to the pathophysiologic mechanisms underlying Professor John Morrison is interested in the the respiratory and cardiovascular effects of air physiology and patho-physiology of the pollution. Within the last two decades, autonomic nervous system and its various target environmental factors such as air pollution have organs, particularly those in the lower urinary been shown to contribute to cardiorespiratory tract. He is PI on a grant for Sheikh Hamdan morbidity and mortality. A growing body of Medical Awards (together with Professor Wim epidemiological data implicates particulate Lammers) on the generation of spontaneous matter air pollution (PM) as yet another factor in activity in the bladder, and the relative roles of the pathogenesis of respiratory and intramural nerves and spontaneous smooth cardiovascular diseases. PM influences muscle activity. These investigations map the susceptibility to hard events and may be spread of electrical activity in the bladder, the particularly harmful to high-risk groups such as sites of pacemakers and the effects of distension people with diabetes, people with hypertension, on the spread of excitation. Another long-term and elderly people. However, the interest is in diabetic neuropathy, and the STZ pathophysiologic mechanisms underlying these model of Type I diabetes and the MSG and GK associations are not fully understood. Recently, models of Type II diabetes have been studied. through a series of experimental studies, with his For the STZ model it takes about 12 weeks for collaborators, Dr Nemmar provided biological clear significant changes in peripheral nerve plausibility for the associations between markers to appear, while in the Type II models, particulate air pollution and cardiorespiratory these changes appear around the time that events. In this context, Dr Nemmar has glucose tolerance becomes evident, usually

73 Department of Physiology

around one year of age in the rat. These investigations have included studies on catecholamine metabolism and handling at nerve endings, the levels of peptide markers as well as sensory testing. More recently changes in gene expression in sympathetic and dorsal root ganglia have been studied using real time RT-PCR. There have been dramatic differences in the expression of genes encoding neurotransmitter synthesis, transport, metabolism and reuptake in different parts of the sympathetic chain.

Changes in gene expression in the diabetic eye, in sympathetic and dorsal root ganglia, corpus cavernosum and vascular tissues are being investigated by low density expression array in studies funded by the Emirates Foundation and the FMHS by Professors Adrian and Morrison.

Diabetes and heart function Human and animal studies have shown that diabetes can be associated with altered cardiac function that is independent of vascular complications. A variety of techniques including biotelemetry, electrophysiology, molecular biology and confocal microscopy are being employed to investigate the cellular and sub- cellular mechanisms which may be responsible for contractility and heart rhythm defects in the diabetic heart.

Acquisition of electrocardiography data in the Biotelemetry Laboratory

74 Department of Physiology

Howarth FC, Almugaddum FA, McLean M, Howarth FC. (2008). Articles in Peer- Qureshi MA, Ljubisavijevic M. Does undergraduate research reviewed Journals (2008). Effects of varying intensity constitute scholarship? Drawing exercise on shortening and on the experiences of one medical intracellular calcium in ventricular faculty. Journal of the Scholarship Ali BH, Blunden G, Tanira MO, myocytes from streptozotocin ofTeaching and Learning, 8: 72-87. Nemmar A. (2008). Some (STZ) – induced diabetic rats, phytochemical, pharmacological Molecular & Cellular Biochemistry, Melstrom LG, Bentrem DJ, Salabat and toxicological properties of 317: 161-167. MR, Kennedy TJ, Ding XZ, Strouch ginger (Zingiber officinale Roscoe): M, Rao SM, Witt RC, Ternent CA, a review of recent research. Food Howarth FC, Qureshi MA. (2008). Talamonti MS, Bell RH, Adrian TE. Chem Toxicol, 46 (2):409-20. 6. Myofilament sensitivity to Ca2+ in (2008). Overexpression of 5- ventricular myocytes from the lipoxygenase in colon polyps and Ali BH, Al-Moundhri M, Tageldin Goto-Kakizaki diabetic rat, cancer and the effect of 5-LOX M, Al Husseini IS, Mansour MA, Molecular & Cellular Biochemistry, inhibitors in vitro and in a murine Nemmar A, Tanira. (2008). 315: 69-74. model. Clin Cancer Res. 15:14, Ontogenic aspects of cisplatin- 6525-6530. induced nephrotoxicity in rats. Howarth FC, Jacobson M, Food ChemToxicol, 46(11):3355-9. Shafiullah M, Adeghate E. (2008). Morrison JFB, Dhanesekeran SM, Long-term effects of type 2 Howarth FC. (2008). Neuropeptide Ali BH, Al-Moundhri M, Eldin MT, diabetes mellitus on heart rhythm Y and CGRP concentrations in the Nemmar A, Al-Siyabi S, Annamalai in the Goto-Kakizaki rat, rat tail artery: effects of age and K. (2008). Amelioration of cisplatin- Experimental Physiology, 93: two type of diabetes, Peptides. induced nephrotoxicity in rats by 362-369. ePub November 2008. tetramethylpyrazine, a major constituent of the Chinese herb Lammers WJEP, Ver Donck L, Nemmar A, Melghit K, Ali BH. Ligusticum wallichi. Exp Biol Med Stephen B, Smets D, Schuurkes JAJ. (2008).The acute proinflammatory (Maywood), 233(7):891-896. (2008). Focal activities and re- and prothrombotic effects of entrant propagations as pulmonary exposure to rutile TiO2 Cukic M, Kalauzi A, Ilic T, Miskovic mechanisms of gastric nanorods in rats. Exp Biol Med M, Ljubisavljevic M. (2008). The tachyarrhythmias. (Maywood), 233(5):610-9. influence of coil-skull distance on Gastroenterology, 135, 1601-1611. transcranial magnetic stimulation Nemmar A, Inuwa IM. (2008). motor-evoked responses. Exp Lammers WJEP Michiels B, Voeten Diesel exhaust particles in blood Brain Res. 2008 Sep 12. [Epub J, Ver Donck L, Schuurkes JAJ. trigger systemic and pulmonary ahead of print] (2008). Mapping slow waves and morphological alterations.Toxicol spikes in chronically instrumented Lett., 176 (1):20-30. Geys J, Nemmar A, Verbeken E, conscious dogs. Part II: Automated Smolders E, Ratoi M, Hoylaerts M, on-line electrogram analysis. Med Rizk DE, Hassan HA, Al-Marzouqi Nemery B, Hoet PH. (2008). Acute Biol Eng & Comp 2008. AH, Shafiullah M, Fahim MA. Toxicity and Prothrombotic Effects (2008). Combined estrogen and of Quantum Dots: Impact of Lammers WJEP,Stephen B. (2008). ghrelin administration decreases Surface Charge. Environ Health Origin and propagation of expression of p27(kp1) and Perspect, 116(12):1607-13. individual slow waves along the proportion of isomyosin type I in intact feline small intestine. Exp the striated urethral and anal Hennig R, Osman T, Esposito I, Physiol 93: 334-346. sphincters and levator ani of old Giese N, Rao SM, Ding XZ, Tong ovariectomized rats. Int WG, Büchler MW, Yokomizo T, Lammers WJEP, Cheng LK. (2008). Urogynecol J Pelvic Floor Dysfunct, Friess H, Adrian TE. (2008). BLT2 is Simulation and analysis of spatio- Oct 19(10): 1363-9, Epub 2008. expressed in PanINs, IPMNs, temporal maps of gastrointestinal pancreatic cancer and stimulates motility. Biomedical Engineering Rizk DE, Fahim MA. (2008). Ageing tumour cell proliferation. Br J Online. 7.2. of the female pelvic floor: towards Cancer. 99:1064-73. treatment a la carte of the Li X, Roginsky AB, Ding XZ, “geripause”.Int Urogynecol J Pelvic Howarth FC, Chandler NJ, Kharche Woodward C, Collin P, Newman Floor Dysfunct, Apr 19(4): 455-8, S,Tellez JO, Greener ID, Yamanushi RA, Bell RH Jr, Adrian TE. (2008). Epub 2008. TT, Billeter R, Boyett MR, Zhang H, Review of the apoptosis pathways Dobrzynski H. (2008). Effects of in pancreatic cancer and the anti- Rizk DE, Hassan HA, Al-Marzouqi streptozotocin-induced diabetes apoptotic effects of the novel sea AH, Ramadan GA, Al-Kedrah SS, on connexin43 mRNA and protein cucumber compound, Frondoside Daoud SA, Fahim MA. (2008). expression in ventricular muscle, A. Ann N Y Acad Sci. 1138: 181- Combined estrogen and ghrelin Molecular & Cellular Biochemistry, 198. administration restores number 319: 105-114. of blood vessels and collagen type

75 Department of of Physiology

I/III ratio in the urethral and anal International Conference on 2008, Auckland, New Zealand. canal subvmucosa of old Transcranial Magnetic Stimulation ovariectomized rats. Int and Direct Current Stimulation. Egbuji JU, Du P, O’Grady G, Urogynecol J Pelvic Floor Dysfunct, October 1-4, Gottingen, Germany. Lammers WJ, Cheng LK, Windsor Apr 19(4): 547-52, Epub 2007. Brain Stimulation, 1(3): 305-306. JA, Pullan AJ. (2008). In-vivo high- density mapping of gastric Nemmar A, Melghit K, ALI BH. electrical activity. Asia-Oceania k (2008).The Acute Proinflammatory Top University League on and Prothrombotic Effects of Engineering (AOTULE) Pulmonary Exposure to RutileTiO2 Postgraduate Conference, Nanorods in Rats. International Auckland. Books, Chapters, Conference of the American Reviews and Thoracic Society,Toronto, Ontario, Egbuji J, Du P,O’Grady G, Lammers May 16-21, 2008. Am. J. Respir. Crit. WJ, Cheng L, Windsor JA, Pullan A. Editorials Care Med., 177: A163. (2008). In-vivo high density mapping of gastric electrical Ljubisavljevic M. (2008). activity. Engineering & Physical Transcranial Magnetic Stimulation. k Sciences in Medicine, Christchurch. In: Encyclopedia of Neuroscience edited by U. Windhorst, M. Binder Fahim MA, Mantilla CB, Zhan W, and N. Hirokawa. Pub: Springer Proceedings, Shokat KM, Ginty DD, Sieck GC. Berlin Heidelberg. ISBN 978-3-540- (2008). Inhibition ofTrkB signaling 23735-8 pp 4091-4096. Conferences, alters neuromuscular junction Invited lectures, ultrastructure. Society for k Web Sites and Neuroscience, 22: 2008. Others Fahim MA. (2008). Inhibition of TrkB signaling alters Adrian TE. (2008). Discovery and neuromuscular junction Published Characterization of a Novel Growth ultrastructure,The FASEB Journal. Abstracts, letters Related Cancer Gene. Pancreas 2000 Conference: Karolinska Howarth FC, Zilahi E, El Haj MA, and Institute, Angavallen, Sweden. Nowotny N, Lei M. (2008). Correspondence Remodeling of ion channel Adrian TE. (2008). Studies on a proteins may partly underlie Novel Growth-Related Gene electrophysiological defects in the Cravero J, Adrian K, Quinn C, in Pancreatic Cancer. Department diabetic rat heart, The 9th UAE Pelham C, Adrian TE, Grippo P. of Physiology, University of University Research Conference, (2008). COX-2 expression in el- Southern Illinois School of 56. positive cells induces aberrant Medicine, Carbondale, IL, USA. duct development. Pancreas 37: Howarth FC, Ljubisavijevic M, 466, 2008. Al-Shuaib WB, Hasan MY, Fahim Qureshi MA, Almugaddum FA. MA. (2008). Modulation of (2008). Effects of varying intensity neuronal potassium current by exercise on shortening and Heiferman MJ, Ujiki MB, Salabat vitamins. Society of Neuroscience, intracellular calcium in ventricular MR, Strouch MJ, Heiferman DM, 18:2008. myocytes from streptozotocin- Cheon EC, Zarlengo DJ, Silveramn induced diabetic rats,The 9th UAE R, Adrian TE, Bentrem DJ. Du P, J.U. Egbuji, O’Grady G, University Research Conference, Sansalvamide analog induces G1 Lammers WJ, Pullan AJ, Windsor 58 cell-cycle arrest through JA, Cheng LK. (2008). upregulation of P21 and doen Computational simulation of Howarth FC, Qureshi M, Nowotny regulation of CDK4 and cyclin E in gastric electrical activity. Asia- N, Zilahi E, Al Haj A, Lei M. (2007). pancreatic cancer cells. Pancreas OceaniaTop University League on Altered expression of ion transport 37: 475, 2008. Engineering (AOTULE) genes may partly underlie heart Postgraduate Conference, rhythm disturbances in the Ljubisavljevic M, Dhanasekaran S, Auckland. streptozotocin-induced diabetic Maric J, Blesic S, Filipovic S. (2008). rat heart, Life Sciences, Glasgow, The effects of two different Egbuji J, O’Grady G, Du P,Cheng L, PC165. repetitive TMS stimulation Wahab A, Lammers WJ, Pullan A, protocols on muscle fatigue Windsor J. (2008). Laparoscopic O’Grady G, Du P,Egbuji J, Cheng L, associated changes in excitability measurement of human gastric Wahab A, Lammers WJ, Pullan A, of motor cortex in man. electrical activity. HealtheX Windsor J. (2008). A novel device Proceeding of the Third Conference, September 12th, for the laparoscopic measurement

76 Department of Physiology of gastric electrical activity and in- P Collin vivo validation in a porcine model. UAEU individual Grant Effects of and Mechanism of Engineering and Physics in Science Frondoside A, a Novel Anti- and Medicine, and the Australasian Prof C Howarth Cancer Agent. [2007-2010]. Bioengineering Conference, Altered gene expression of ion Christchurch, New Zealand. transport proteins underlies Profs TE Adrian (PI), F Safi and Dr ventricular arrhythmias in P Collin O’Grady G, Egbuji JU, Du P, alloxan-induced non-insulin- Marine Mussel Oil for Cancer Cheng LK, Wahab A, Lammers dependent diabetic rats”. Grant Treatment. [2009-2012]. WJ, Pullan AJ, Windsor JA. (01-05-8-11/09) (2008). A novel laparoscopic Emirates Foundation device for the measurement of Prof C Howarth gastrointestinal slow wave Sinoatrial node dysfunction in Profs TE Adrian (PI), JFB Morrison, activity and in-vivo validation the streptozotocin-induced A Perrin and Dr R Hennig. in a porcine model. Asia- diabetic rat heart. (01-05-8- The expression of genes in Oceania Top University League 11/07) neurons and the tissues they on Engineering (AOTULE) innervate during the development Postgraduate Conference, Drs A Nemmar (PI), S. Al-Salam. ofType 2 diabetic neuropathy and Auckland. Effect of diesel exhaust particles retinopathy in two animal models on cerebral microvessel and in human tissues. Emirates thrombosis, pulmonary and Foundation grant (2009-2011). k systemic oxidative stress: Influence of a cysteine prodrug, Drs A Nemmar (PI), S Al-Salam, Prof L-2-oxothiazolidine-4-carboxylic E Kazzam. acid. [2008-2009] Experimental studies on the Research Grants interactions between pulmonary UAEU Interdisciplinary Grant exposure to particulate air FMHS New Research Grant pollution and hypertension: Profs TE Adrian, F Branicki, J Pathophysiologic mechanisms and Profs TE Adrian (PI), JFB Morrison. Permert, and Dr D Kelly influence of protectant drugs. Gene Expression in Diabetic Expression of Genes Emirates Foundation grant (2009- Retinopathy and Cataract. Predisposing to Type II diabetes 2011). (NP/08/10) in the UAE. [2007-2009] National Research Foundation Prof C Howarth Prof C Howarth (PI), Prof. M. Remodelling of ion transport Ljubisavljevic, Dr. M. Jacobson Profs L Al-Gazali (PI), EA Adeghate, proteins underlies abnormal Exercise induced remodelling of TE Adrian (Co-PI), BK Al Ramadi, electrical conduction in the diabetic cardiomyopathy in STZ- and Drs BR Ali, OM El-Agnaf streptozotocin-induced diabetic induced diabetic rats. (01-03-8- Genes and Diseases Research rat heart. (NP/08/01) 12/06) Center of Excellence (2009-2114).

Prof C Howarth Hamdan Award Medical Others Progressive effects of type 2 Research Grant diabetes mellitus on heart function Profs TE. Adrian (PI), S Gariballa, in the Goto-Kakizaki rat (NP/07/10) Profs JFB Morrison (PI), WJEP and Drs H Saadi, J Al Kabbi. Lammers, Ms B Stephen, Mr S Release of Rectal Hormones for Prof. M Ljubisavljevic Dhanasekaran. Weight Loss and Improvement of rTMS induced modulation of The generation and spread of Type II Diabetes Mellitus. Satiagen fatigue-induced cortical plasticity. electrical and contractile Inc, San Diego, California, USA Neurophysiological and activities in smooth muscles of (2008-2009). behavioural correlates. the lower urinary tract and the effects of aging and diabetes Dr F Hammad (PI), Prof WJEP k Lammers, Ms B Stephen Prof. M Ljubisavljevic, Dr. S. Spatial and temporal electrical Shehab (P.I.) impulse propagation in the normal Does high frequency stimulation and the obstructed ureter. of the substantia nigra suppress tonic epileptic seizures? Prof WJEP Lammers (PI), Dr H Mirghani, Ms B.Stephen Terry Fox Cancer Research The effects of oxytocin on the Grant electrical and contractile activities in the pregnant guinea-pig uterus. Profs TE Adrian (PI), F Safi and Dr

77 Department of Physiology

Standing left to right: Ms S Zia, Mr A Qureshi, Mr Saeed Ali Kutty, Prof C Howarth, Prof W Lammers, Prof M Ljubisavljevic, Ms B Stephen, Ms Fadwa A Almugaddam Seated left to right: Ms Sneha Ann Thomas, Ms Khatija Parekh, Prof TE Adrian, Prof M Fahim, Mr P Rajagopalan, Mr S Dhanasekaran, (Dr2008 Nemmar and Prof MorrisonPhysiology were not available for the photograph)

http://www.fmhs.uaeu.ac.ae/Departments/Physiology Tel: 7672000 / Fax: 7671966

78 Department of Psychiatry and Behavioural Sciences

Departmental Profile

Departmental Profile and Research Themes: Professor & Chair: Prof Omer El-Rufaie 1. Epidemiological aspects of common mental health disorders Professor: in primary health care and community settings Prof Rafia Ghubash Prof M Reza Sadeghi (a) First-episode psychosis presenting at the Psychiatric Associate Professor: Department of Al-Ain Hospital. (Dr. M.O. Salem). Dr Kanita Dervic Dr Hamdy F. Moselhy (b) A study of the prevalence, socio-demographic correlates Dr Ossama T. Osman and co-morbidity of premenstrual dysphoric disorder in the Assistant Professor: primary care. (Dr. O. Osman). Dr Lina Amiri Dr Hanan Hassanin (c) A 10-year retrospective study of the prevalence and correlates Dr Mohamed O Salem of various psychiatric diagnoses among inpatient admissions to Research Assistant: Al-Ain Hospital.(Dr. O. Osman). Dr Sufyan Sabri Mr Saeed Yousef (d) Suicidal behavior and suicide prevention in childhood, Medical Secretary: adolescence and adulthood. (Dr. K. Dervic ). Miss Aisha Al-Shamsi Secretary: (e) Affective and anxiety disorders in childhood and Mr D Ranganathan adolescence.(Dr. K. Dervic and Dr. L. Amiri). Office Assistant: Mr O Pocker (f) Effect of stress, depression, social support, and coping on psychological distress of patients with Ischemic heart disease. (Prof. M.R. Sadeghi).

(g) Prevalence of teenager depression in Al Ain. (Prof. M.R. Sadeghi)

(h) Prevalence and correlates of suicidality in rural population of Pakistan. (Prof. M.R.Sadeghi).

(i) Life satisfaction among older adults in UAE. (Dr. H. Moselhy).

2. Personality, psychosocial and transcultural aspects of physical illness

(a) Association of Irritable Bowl Syndrome with personality traits and with anxiety and depressive disorders. (Prof. O. El Rufaie). Department of Psychiatry and Behavioural Sciences

(b) Psychological and social intervention in 6. Women’s Mental Health patients undergoing bariatric surgery. (Dr. O. Osman). (a) A study of symptoms expression of PMDD in women in the Primary Care. (Dr. O. Osman). (c) Personality disorders, life-events and suicidal behaviour. (Dr. K. Dervic) (b) Psychosocial study of pregnant women with foetal abnormalities.(Dr. O. Osman). (d) Depressive disorders as a risk factor in susceptibility to coronary heart disease. (Dr. H. (c) A study of the post-partum psychiatric Moselhy). disorders in Al Ain.(Dr. O. Osman).

(e) Relation of brain lesion and apathy, (d) Maternal anxiety and depression Following depression, cognition and daily function in a diagnosis of Gestational Diabetes Mellitus stroke patients. (Dr. H. Moselhy). (Prof. M.R. Sadeghi).

3. Cultural aspects of psychiatry 7. Postgraduate Education and Training

(a) Help seeking behaviour of psychiatric (a) Arab Board curricular development in patients before attending the psychiatric psychiatry (Dr. O.Osman). services at Al-Ain Hospital. (Dr. M.O. Salem). (b) Survey of Arab Board programs for structural (b) Colour preference of patients attending the and procedural organizations (Dr. O. Osman). Psychiatric Department of Al-Ain Hospital. (Dr. M.O. Salem). (c) Research training in Child & Adolescent Psychiatry at the Medical University of Vienna, (c) Time estimation of patients with psychiatric Austria. (Dr. K. Dervic). morbidity attending Al-Ain Hospital. (Dr. M.O. Salem). 8. Recent translation, development and (d) Cross-cultural child and adolescent validation of psychiatric instruments for use psychiatry. (Dr. K. Dervic). among Arabic speaking population.

4. Dream Research • Mini-International Neuropsychiatric Interview (MINI) (Dr. O. Osman). (a) Effect of dreams on psychiatric patients presenting at Al Ain Hospital psychiatric clinic. 9. Genetic Study: (Dr. M.O. Salem). (a) Molecular genetic study of schizophrenia in an Arab population (Dr. H. Moselhy) (b) Significance of dreams among UAE University students. (Dr.M.O. Salem).

(c) Effect of watching movies on the viewer's dreams in a sample of UAE University students.(Dr.M.O.Salem).

5. Psychotherapy

• Cognitive Behaviour GroupTherapy (rCBGT) for Breast Cancer Patients with Psychiatric. Morbidity: Controlled Study- in collaboration with the Dept of Psychiatry, Faculty of Medicine, Alexandria University.(Dr. M.O.Salem).

80 Department of Psychiatry and Behavioural Sciences

Islamic Medical Association of in Childhood. Psychiatric Articles in Peer- North America (JIMA). 40(4);1- Clinics of North America 31(2); reviewed Journals 12. 271-91.

Voracek M, Loibl LM, Kapusta Salem MO. (2008). Light on the N, Niederkrotenthaler T, Dervic Path: My second book on Blasco-Fontecilla H, Baca- K, Sonneck G. (2008). Not supported self-help for rCBT, Garcia E, Dervic K, Perez- carried away by a moonlight (336 pages, in Arabic), Al- Rodriguez M, Saiz-Gonzalez D, shadow: no evidence for Resallah Publications, Beirut. Saiz-Ruiz J, Oquendo MA, de associations between suicide Leon J. (2008). Severity of prevalence and lunar phase personality disorders and among more than 65,000 suicide attempt. Acta k suicide cases in Austria, 1970- Psychiatrica Scandinavica 2008 2006.Wiener Klinische Nov 10. [Epub ahead of print]. Published Wochenschrift 120/11-12; 343- 349. Abstracts, Eapen V, El Rufaie O. (2008). United Arab Emirates (UAE). letters and Younis A, Moselhy H. (2008). International Psychiatry Vol.5, Benzhexol-dependence Correspondence No.2; 38-40. resulting from self-medication of intermittent explosive Kapusta ND, disorder. International journal El Rufaie OEF. (2008). Somatisation Niederkrotenthaler T, of psychiatry in clinical practice and Somatised Mental Disorder. Etzersdorfer E, Voracek M, 1-5 (Epub ahead of print). Psychosomatic Medicine Vol 70; Dervic K, Jandl-Jager E, No3.A. Sonneck G. (2008). Influence of Younis A, Moselhy H. (2008). Psychotherapist Density and Lycanthropy alive in Babylon: Osman OT. (2008). Premenstrual Antidepressant Sales on the existence of archetype. Dysphoric Disorder in the UAE Suicide Rates. Acta Psychiatrica ACTA Psychiatrica Scandinivia primary care women. Scandinavica 2008 Dec 4. Journal 1-4; (Epub ahead of Psychosomatic Medicine Vol 70; [Epub ahead of print]. print). No. 3A. Niederkrotenthaler T, Till B, Herberth A, Kapusta N, Voracek M, Dervic K, Etzersdorfer E, k k Sonneck G. (2008). Can Media Effects Counteract Legislation Reforms? The Case of Proceedings, Adolescent Firearm Suicide in Books, Chapters, the Wake of the Austrian Reviews and Conferences, Firearm Legislation. Journal of Editorials Invited lectures, Adolescent Health 2009 Jan; Web Sites and 44(1); 90-3. Epub 2008 Oct 18. Akkaya-Kalayci T, Dervic K, Friedrich MH. (2008). Others. Osman OT, Younis A, Almirii Z. Modellprojekt "Ambulanz für (2008). Infanticide Attempt by transkulturelle Psychiatrie und Dervic K. (2008). Presuicidal A Postpartum Depressed migrationsbedingte Störungen Syndrome in Childhood and Mother. J. Emergency Med, des Kindes- und Jugendalters" Adolescence. Annual Meeting Trauma and Acute Care an der Wiener Universitätsklinik of the Austrian Association of (JEMTAC) Vol June No.2; 122- für Psychiatrie des Kindes- und Pediatricians, Seggau, Austria. 123. Jugendalters. In:Von Gemeinsamkeiten und Dervic K. (2008). Annual Salem MO, Moselhy HF, Attia H, Unterschieden. Sammelband; Symposium of the Austrian Yousef S. (2008). Clinical 1. Kongress der Association of Child and Characteristics of first episode transkulturellen Psychiatrie im Adolescent Psychiatry – psychosis: a study in Al Ain, deutschsprachigen Raum 6-9. (ÖGKJP), Suicidal Behaviour in UAE. Arab Journal of Psychiatry September 2007, Universität Children and Adolescents in Vol. 19 (2); 25-35. Witten/Herdecke; Verlag für Austria, Pollau, Austria. Wissenschaft und Bildung Salem MO, Ali MM. (2008). (VWB). Dervic K. (2008). Epidemiology Psycho-Spiritual Strategies in in Child and Adolescent treating Addiction patients: Al- Dervic K, Brent DA, Oquendo Psychiatry on Example of Amal Hospital experience, MA. (2008). Completed Suicide Suicide Research. Annual Saudi Arabia. Journal of the Meeting of the Austrian

81 Department of Psychiatry and Behavioural Sciences

Association of Child and Moselhy H. (2008). Aripiprazol and organization. 13th Adolescent Psychiatry (ÖGKJP), treatment in 12 patients with International - 2nd World Linz, Austria. obsessive compulsive disorder. conference of A.P.P.A.C. 13th Pacific Rim College of Dervic K. (2008). Suicidality in Psychiatric Scientific Meeting Sadeghi MR. (2008). Cognitive Childhood and Tokyo, Japan. behavior therapy: the most Adolescence,Viennese Social effective psychological Pedagogues Meeting, Vienna, Moselhy H. (2008). Comorbidity treatment for moderate and Austria. of anticholinergic abuse and severe depression. Taravat intermittent explosive Bahar Institute (NGO). Mashhad. Dervic K. (2008). disorders. 13th Pacific Rim Psychopharmacological College of Psychiatric Scientific Sadeghi MR. (2008). Behavioral Treatment of Children and Meeting, Tokyo, Japan. modification program for Adolescents. Annual management of problem Symposium of the Austrian Osman OT. (2008). Symptoms behavior of persons with Association of Child and Expression in Premenstrual intellectual disability. Tawam- Adolescent Psychiatry – Dysphoric Disorder in the UAE. Yab Welfare Institute, Mashhad. (ÖGKJP) , Invited Workshop, The American Psychosomatic Pöllau, Austria. Society 66th Annual Scientific Sadeghi MR. (2008). Meeting. Baltimore, USA. Occupational Stress Dervic K. (2008). Suicidal Assessment of ADMA-OPCO behaviour in childhood and Osman OT. (2008). Prevalence Staff: Implications and adolescence – risk factors, of Premenstrual Dysphoric Recommendations. ADMA prevention and treatment Disorder Among Primary Care Occupational Stress Campaign. Viennese Medical Chamber, Patients in Al-Ain. The XI Pan Abu Dhabi. Continuing Medical Education Arab Conference in Psychiatry, course for school doctors, Damascus. Salem MO, Mustafa AK. (2008). Vienna, Austria. Workshop on the Spiritual Osman OT. (2008). Cognitive interventions in psychotherapy. Dervic K, Kapusta ND, Decline Among the Elderly: The 4th International Niederkrotenthaler T, Aysel M, from Senility to dementia. Abu Conference on Psychiatry, SGH, Voracek M, Loibl LM, Meng H, Dhabi International Aging Jeddah, Saudi Arabia. Sonneck G, Friedrich MH. Conference. (2008). Are there temporal Salem MO, Younis AA, El Banna variations in youth suicides? Osman OT. (2008). Post-partum A, Saleh B, Yousif S. (2008). Abstract book,18. World Depression. 3rd International Effect of Dreams on psychiatric Congress of the International Conference of Al Noor: Patients in a UAE Study, Dreams Association for Child and Psychiatry in General Practice, without Borders. The 25th Adolescent Psychiatry and Abu Dhabi. Annual Conference of the Allied Professions (IACAPAP), International Association for Istanbul, Turkey. Osman OT. (2008). Developing the Study of Dreams (IASD), the Arab Board Curriculum for Montreal, Canada. El Rufaie OEF. (2008). The 3rd Psychiatry. The XI Pan Arab Biennial Conference of the Conference in Psychiatry, Salem MO. (2008). Cognitive International Society of Bipolar Damascus. aspects of sleep and dreaming. Disorder. Prevalence of 5th International Conference cognitive function and mental Osman OT. (2008). Participation on Information Technology and disorders among the UAE in the Lundbeck Institute Cognitive Sciences, Al Ain, UAE. elderly Population. Delhi, India. Conference on: Evidence Based Medicine in Schizophrenia, Salem MO. (2008). Workshop on: El Rufaie OEF. (2008). Hurghada, Egypt. Theories and methods of dream Somatisation and somatised research. The 5th Alexandria mental disorder. American Osman OT. (2008). Prevalence International Congress on Psychosomatic Society. 66th and correlates of premenstrual Psychiatry, Alexandria, Egypt. Annual Scientific Meeting dysphoric disorder in Al Ain Baltimore USA. primary care. Program Salem MO. (2008). Workshop on Abstracts. XI Pan Arab the Spiritual aspects of Moselhy H. (2008). The profile of Conference in Psychiatry, psychiatry for the elderly. Iraqi juvenile delinquents Damascus, Syria. Elderly Home Care Conference, during the sanction period. RAK, UAE. 13th Pacific Rim College of Sadeghi MR. (2008). Psychiatric Scientific Meeting Occupational stress and its Salem MO. (2008). Participation Tokyo, Japan. consequences on employees in the Lundbeck Institute

82 Department of Psychiatry and Behavioural Sciences

Conference on: Evidence Based Medicine in Schizophrenia, Hurghada, Egypt. k

Research Grants

UAEU Interdisciplinary Grant

Eapen V, Moselhy H [PI], Ali Basam. Association of serine race mase gene, PDLIM5 gene and PICK 1 gene polymorphism and schizophrenia. (2007-2009] k

Psychiatry 2008http://www.fmhs.uaeu.ac.ae/psy/psych.htm Tel: 7672000 / Fax: 7672995

83 Department of Radiology

Research Profile

Professor & Chair: Our research interests are focussed on common Prof P Corr medical and health issues in the UAE. Professor: Prof R Langer Associate Professor: Trauma Dr K N van Gorkom Trauma imaging is an important part of our daily work and road Teaching Assistant: traffic accidents a major cause of morbidity and mortality in Dr T Al Mansoor the UAE. We have been working with colleagues in orthopaedic Administrative surgery to establish the role of radiographs and three dimensional Assistant: computed tomographic models of the skeleton in assessing the Ms R Ahmed type and extent of fractures. Sports Medicine Imaging We continue our interest in injuries sustained by sportsmen especially long distance runners and soccer players. We investigated knee injuries in runners this year and are currently investigating changes in Hoffa’s fat pad in the knee joint following trauma and osteoarthrosis of the knee.

Osteoporosis and Body Fat Composition in Peri- Menopausal Women Osteoporosis is an under recognized health problem in UAE national women and is the major cause of bone fractures in older women. We are currently measuring the bone density and body fat composition of peri-menopausal women living in Al Ain to determine if there is a direct correlation between the body composition values (percentage body fat and lean mass) and bone mineral density using dual energy X-ray absorption (DEXA) scans.This study will provide a databank of bone mineral density measurements for women living in Al Ain and we hope this study will confirm the correlation between percentage body fat and bone density in women older than 40 years.

Contrast medium research We are active in this area of radiology. Two studies were performed during the year: An in vitro study of the efficiency of adding antibiotics to non-ionic contrast media for intradiscal [UAEU grant 2008/ completed]; collaboration with the FMHS Department of Pharmacology, and international collaboration Department of Radiology with‘Experimental Radiology’,Charité University, Articles in Berlin, Germany and an investigation of the development of NSF after IP administration of Peer-reviewed various GBCA [FMHS grant 2008/ animal Journals experiments ongoing]; collaboration with the FMHS Departments of Pharmacology, Anatomy, Langer R, Neidl v Gorkom K, Raupp P. (2008). Cerebral MRI and international collaboration with manifestations in neonatal ‘Experimental Radiology’, Charité University, tuberous sclerosis. Iran J Radiol, 5: Berlin, Germany. 25ff. We are also currently investigating tumour angiogenesis in vitro cancer cell lines and an Rijke A, Hagemann G, Corr P. (2008). Do knees survive the animal model using a novel MR contrast agent Comrades Marathon? A MR consisting of paramagnetic iron oxide study. S Afr M J;98:872-875. nanoparticles attached to RGD peptide that can potentially be used to detect early cancers in solid organs such as the liver. k

Molecular Imaging We are actively involved in the forthcoming Published PET-CT installation in Tawam Hospital. Clinical Abstractss, research in oncology and neuroscience is letters and pending with this new facility. Correspondence

Neuroimaging Langer RD, Petroianu G, Lorke DE, Neuroimaging plays a key role in analysis, Neidl van Gorkom K, Usmani A, diagnosis and treatment of diseases of the Azimullah S, Nurulain SM. (2008). central nervous system. Magnetic Resonance In Vitro study of the efficacy of Imaging is the tool of choice for the examination adding antibiotics to contrast media at discography to inhibit of the CNS in vivo without ionization radiation. bacterial growth Radiology; Computed assisted evaluation allows for 249(S), 976 morphometric, fine-structural as well as for functional examinations. We are working at the implementation of sophisticated software (FSL k & FreeSurfer) and adaptation to local needs and testing with normative external data-sets is the first step of this project. In a second step a small Proceedings, number of dedicated local MRI examinations Conferences, (Tawam, Al Ain Hospitals) will be evaluated. Invited lectures, These efforts are also related to the upcoming projects in the field of cognitive sciences at the Web Sites and main university. Others.

Textural Analysis in Liver Fibrosis Corr P. (2008). 8th Middle East We have completed a study this year with the Medical Imaging Conference departments of physics and molecular biology 2008, Dubai to assess whether we could quantify textural Invited lecture: Advances in CT disruption of the liver parenchyma in an animal Technology, Assessment of Radiation Dose, Risk vs Benefits model of liver fibrosis. Textural analysis uses digital data from CT and MR images to assess the Corr P. (2008). Musculoskeletal degree of disruption of organ patterns from manifestations of HIV/AIDS. 15th pathological processes such as cancer or fibrosis. Annual Meeting European Society This novel technique improves the sensitivity of for Musculoskeletal Radiology June 2008, Galway, Ireland. digital images in detecting subtle changes in solid organ structures.

85 Langer RD, Neidl van Gorkom K, with Stuewe-Wiedemann syndrome. administration of gadolinium- Obaid Al Kaabi H, Czechowski J, 2nd International Genetics based contrast agents (GBCA). Torab F. (2008). Prospective Conference 2008: 33 comparative study of two imaging UAEU Individual Research Grant protocols in patients with acute stroke. 67th Annual Meeting of the k Prof R Langer [PI], G Petroianu, K Japanese Radiological Society Neidl v Gorkom, D Lorke, A Usmani, (JRS): 24 SM Nurulain, S Azimullah. In vitro study of the efficacy of adding Langer RD, Neidl van Gorkom K, Research Grants antibiotics to nonionic contrast Obaid Al Kaabi H, Czechowski J, media for intradiscal use at Torab F. (2008). Prospective FMHS Research Grant discography in order to reduce comparative study of two imaging bacterial growth protocols in patients with acute Prof R Langer [PI], G Petroianu, D stroke. 67th Annual Meeting of the Lorke, K Neidl v Gorkom, M Japanese Radiological Society (JRS) Agarwal, N Nagelkerke, SM k Nurulain, U Speck: Investigation Langer RD, Al-Gazali L,Varady E, Neidl of the development of van Gorkom K. (2008). Radiographic nephrogenic systemic fibrosis findings in newborns and survivors‘ (NSF) after intra-peritoneal

From left: Dr T Al Mansoor, Dr K N van Gorkom, Ms R Ahmed, Prof R Langer, Prof P Corr 2008Radiology

http://www.fmhs.uaeu.ac.ae/Departments/Radiology Tel : 7672000 Fax : 76722067

86 Department of Surgery

Research Profile

From 1999 until 2001 Prof. Branicki was the sole General Surgeon Professor & Chair: in the Faculty. The appointments of Dr. Fawaz Torab (March Prof Frank J Branicki 2001) and Dr. Fikri Abu Zidan (July 2001) and Professor Farouk Professor: Safi (September 2002) have now enabled the pursuit of Prof Fikri Abu-Zidan subspeciality interests in upper gastrointestinal/bariatric surgery, Prof Farouk Safi trauma care and hepatobiliary/colorectal surgery. Professor Associate Professor: Derek Younge (August 2002) has expertise in the management Dr Fayez Hammad of hand and brachial plexus injuries and musculoskeletal tumours Assistant Professor: in particular, returning to practise in Canada in August 2008. Dr. Dr Ali Al Belooshi Fayez Hammad joined the Department in August 2007, being the Dr Zuhair Al Fardan first Faculty appointee in Urology. Faculty members in the Dr Saeed Al Thani Department have now increased from four (1999) to ten currently, Dr Ali Jawas five of whom are UAE nationals, with five advertised senior Dr Tahira Mahmoud positions (breast/endocrine surgery, minimal access surgery, Dr Fawaz Torab neurosurgery, orthopaedics and otorhinolaryngology) yet to Teaching Assistant: be filled. Dr Mohamed Ali Al Ali Medical Research All Faculty members have Consultant privileges at Al Ain and Specialist: Tawam Hospitals. Teaching Assistant Dr. Ali Jawas successfully Mr Loay Lubbad completed Residency training in General and Vascular Surgery General Technician: at the University ofToronto in 2004 and was appointed Assistant Ms Mahra Al Mansouri Professor in December 2004. Following his training in Vascular Medical Secretary: Surgery he has also completed a Fellowship in Toronto and Ms. Raisa Al Mansouri rejoined us in Al Ain in October 2005. He is actively involved in Secretary: the provision of vascular services. Teaching Assistant Dr. Saeed Mr Abdulla C Jamal Al Thani completed Residency Training in Orthopaedics also at Office Assistant: the University ofToronto and was appointed Assistant Professor Mr Cherukunnumal in July 2004. Following Fellowship training in‘sports injuries, hand Aboobacker and joint replacement surgery’at the same institution inToronto he rejoined the Faculty in Al Ain in January 2006 and has been able to establish a busy Sports Injuries clinic and surgical practice in Tawam Hospital. In Canada, Teaching Assistant Dr. Tahira Mahmoud completed Residency training in Ophthalmology at McGill University, Montreal and a Fellowship period in Ottawa concerned with disease of the anterior chamber of the eye. Appointed Assistant Professor, Dr.Tahra returned to Al Ain in 2006 and is now practising at Al Ain and Tawam Hospitals.

Dr. Zuhair Al Fardan completed Residency training in Plastic Department of Surgery

and Reconstruction Surgery in Toronto, and Fikri Abu Zidan. A question bank that has been subsequently Fellowship training including established is now being consolidated. Dr. Torab, experience in microvascular surgery. Appointed a member of the Faculty CME Committee, has Assistant Professor he returned to the Faculty in also been a member of a Committee which has August 2008 and is actively participating in developed a course in ethics in the General clinical services at Tawam Hospital. Dr. Ali Al Basic University Teaching Year (UGRU). He has Belooshi has also completed his Residency also functioned as a Subcommittee member training in Toronto (Orthopaedic Surgery) and for implementation of Ethics and having been appointed as an Assistant Professor, Professionalism in the Curriculum and is now he undertook an extended period of Chair of the Research Ethics Committee for the subspecialty Fellowship training in lower limb Al Ain Medical District. He has also been arthoplasty including revisional surgery. Dr. appointed to the Research Committee of the Mohamad Al Ali, the most recently appointed Harvard Medical Foundation in Dubai. Teaching Assistant, completed an attachment at Sheikh Khalifa Medical Centre in Abu Dhabi and Prof. Safi took on the role as Director of also underwent training atTawam Hospital. He Postgraduate Training in the Department with undertook a short term period of training in the establishment in June 2005 of a local Toronto for three months in 2007 and has now Residency training program in General Surgery commenced a Residency training opportunity under the auspices of the Arab Board with the for Otorhinolaryngology at the Sahlgrenasks future possibility of Associate MRCS University Hospital in Sweden. accreditation by the Senate of Surgery in the United Kingdom. The Program has been A senior medical laboratory specialist, Mr Loay accredited by the Arab Board in Surgery and Lubbad took up appointment in the Department five Residents were appointed to the first year in May 2008 and is much involved, in particular, of the program in October 2005 and four more with experimental studies of smooth muscle joined the program in 2006. In 2007 Prof. Safi function conducted by Dr. Fayez Hammad. Ms. became the Chair of the Postgraduate Medical Mahra Al Mansouri is a General Technician and Education Committee. Professor Branicki assists with other duties relating to teaching as assumed the role of Acting Program Director well as research. Mr. Abdulla Jamal has been in April 2007 in a revitalized program which has acting for some years as Departmental Secretary been restructured along North American lines. and, facilitates both teaching activities in the In April 2008, Dr. Ali Jawas accepted the Clerkships, workshops and various CME activities invitation to take on responsibilities as Program with dedicated service to a high standard, with Director. Five new Residents joined the program assistance from Mr. Aboobacker in office duties. in July 2007 and following some earlier attrition Ms Raisa Al Mansouri joined the Department the complement of the Residents in the Program as Secretary in May 2008 following secretarial is now thirteen (PGY 1-3), with more highly duties in the Department of Mathematics at the organized Viva Voce and MCQ assessments UAE University. Ms Mansouri is actively engaged during “In Service” training. A Residency with administrative arrangements for teaching Advisory Committee was established in August and CME activity, including the pendingTrauma, 2007 for the new Integrated Training Program Critical Care and Injury Prevention Conference with membership of surgeons from both Sheikh scheduled for February 2009. Khalifa Medical City and Mafraq Hospital in Abu Dhabi and Tawam and Al Ain Hospitals. The Educational Activity: teaching and Program is thus expanding to other sites with training a strong spirit of enthusiasm for these The Department has computerized its teaching collaborative efforts to provide training materials (Blackboard) and is involved in clinical opportunities for Residents in General Surgery. and as well as basic science research activities. The Junior Surgical Clerkship was reorganized Two new initiatives in the UAE, the first with an emphasis on small group teaching and Residency Training Program in Urology case discussion with new initiatives introduced commenced in July 2008 with Dr. Fayez Hammad by the then Clerkship Coordinator, Dr. Fawaz the designated Program Director. A second new Torab, who was succeeded in this role by Dr. program - Residency Training Program in

88 Department of Surgery

Ophthalmology under the directorship of Dr. Tahra Mahmoud commenced in October 2008.

Skills and Procedural Training In April 2004 the Department hosted inaugural back to back Provider and Instructor courses in the UAE for the Advanced Trauma Life Support (ATLS). Four invited Faculty and staff from the USA and one from Canada participated in the teaching and Provider courses have since been held again in the Faculty and in Fujairah. These courses are training Emirati graduates and others in trauma care and will help reduce the burden of disabling illness and mortality from motor vehicle crashes. In 2005 the Department hosted two ATLS courses in Al Ain and members also participated as Instructors in two courses held in Fujairah. Courses were held in the Faculty in March, April, November and December 2006. In addition, Prof. Branicki participated as Faculty for two Instructor Courses held in Abu Dhabi in May 2006. Dr. Ali Jawas and Prof. Derek Younge successfully completed the Instructor Course. In 2006 participation in Courses (teaching activities and assessments) conducted over 2.5 days at weekends was as follows: Dr. Fikri Abu Zidan (4), Prof. Derek Younge (5), Assistant Professors Fawaz Torab (4), Ali Jawas (2) with Frank Branicki who is a Course Director for the Emirate of Abu Dhabi, directing and teaching In March 2008 the FMHS was the site for courses in Al Ain (6), Sheikh Khalifa Medical City inauguration of the Advanced Trauma Provider (5) and Fujairah (1). Course for Nurses (ATCN) in the UAE, followed by an ATCN Instructor course and a second In 2007 ATLS activities continued with Provider Course in November 2008. These participation of Faculty members as follows: activities run in concert with ATLS courses are Prof. Fikri Abu Zidan (2), Prof. DerekYounge (4), made possible with the enthusiastic Prof. Frank Branicki (6) being the Course Director participation of Instructors fromTawam Hospital. and Faculty for courses in Al Ain as well as In addition, the Pre-HospitalTrauma Life Support teaching courses in Fujairah (2). In 2008 Faculty Course (PHTLS) has been conducted in Tawam participation as Instructors continued in Al Ain Hospital with Prof. Branicki acting as Faculty in with courses taught by Dr. Ali Jawas (1) and December 2008. Prof. Branicki (2) and Fujairah Dr. Fawaz Torab (1) and Prof. Branicki (1). By December 2008 a total The Department has organized a number of of 889 doctors had been trained in 41 Provider CME/CPD activities including an International and 5 Instructor courses – all of this made Surgical Conference with more than 600 possible with active participation of Instructors delegates held in Abu Dhabi in October 2003. (Anaesthetists, Emergency Medicine Physicians This was highly successful with fourteen invited and Surgeons) at Tawam Hospital. Several international Faculty and 72 free paper Faculty also participated in an international presentations of research activity from the UAE Emirates Trauma and Emergency Surgery and elsewhere. The Department raised 75% of Conference which took place in Fujairah in May funding required for the meeting from corporate 2006. Data relating to ATLS courses and training sponsorship. Members of the Department were have been presented nationally and at involved in Pre-conference Surgical Skills International Surgical Congresses. workshops in January and November 2004 and

89 Department of Surgery

Dr. Fawaz also organized the 1st Middle East generously sponsored an education grant for Forum and Workshop on “Virtual Reality for administrative support, etc, to enable CME/CPD Skills Training in Medicine”in May 2004. activity in the recently established Clinical Skills Training Center at FMHS. By the end of 2008 a The Department is now designated a training total of 10 FAST courses had been conducted centre for laparoscopic surgery simulation and with 216 doctors trained. practice by the European Association of Endoscopic Surgeons (EAES). Dr. Torab is the With the support of Faculty Administration it has Founding President of the recently established been possible to establish a Clinical Skills and entity – the UAE Chapter of the European Procedural Training Centre which is a Association for Endoscopic Surgery (EAES-UAE), multidisciplinary venture to foster training for with 42 members, and has organized 17 basic undergraduates and particularly Residents in and advanced laparoscopic workshops involving a variety of clinical disciplines. Dr. FawazTorab, bench top trainers, surgery in animal models and who received the Faculty Award forTeaching in ‘Virtual Reality’surgical simulations. April 2007, is the Director of the Center with basic and advanced laparoscopic courses Prof. Fikri has received two ultrasound machines planned in collaboration with industry who donated by the Red Crescent Society to the have strongly supported the project financially. Department of Surgery which are to be used for Both FAST and ATLS courses are accommodated the detection of free intrabdominal fluid (FAST) as need be, and also courses in laparoscopic in trauma. The machines have also helped to gynaecological surgery and fetal facilitate teaching and research activities in ultrasonography. FAST trainers include, trauma and other fields. Two FAST workshops for cardiologists, nephrologists, obstetrician/ training in ultrasonography have been gynaecologists, radiologists and surgeons. This conducted by Dr. Fikri Abu Zidan and colleagues exciting initiative has been made possible with in 2004, 2005, and again in 2006. Dr. Fikri donations from instrument and equipment organized a FAST workshop at a meeting of the manufacturers. A number of Interns and 7th European Congress of Trauma and Residents in the General Surgery training Emergency Surgery which took place in Malmo, program have successfully completed ATLS, Sweden in September 2006. Subsequently, he FAST and laparoscopic training Courses. was instrumental in facilitating the donation by SonoSite of six portable, hand held, Education and Research ultrasound machines for education purposes Administration in the Faculty of Medicine and Health Sciences Many Faculty are also heavily involved in at UAE University. SonoSite have since administration of research activities – these

90 Department of Surgery

include the Chairs of Research Grants AtTawam Hospital Prof. Branicki is a member of Committee, (Prof. Branicki, 2000-2004), Research the Ethics and Consultation Committee, the Ethics Committee (Dr. FawazTorab, 2002-2004), Trauma Committee and also chairs the Quality Trauma Strategic Research Priority Group (Dr. Improvement Committee for the Department of Fikri Abu Zidan, 2002-to date) and Oncology Surgery, Dr. Fawaz Torab also being a member Strategic Research Priority Group (Prof. of this Committee. He is also a member of the Tjernstrom, 2002-2007), and the Postgraduate Infection Control Committee and the Nutritional Education Committee (Prof. Farouk Safi, 2007 – Committee atTawam. Dr. Fikri is Co-chair of the to date), Drs. Torab and Fikri are members of Trauma Committee. the Research Advisory Board (RAB). Prof. Branicki , a former member of the RAB, also Prof. Branicki acted as Chair of three chairs the Undergraduate Curriculum Policy Subcommittees for Sheikh Hamdan Awards in and Review Committee (2006 – to date), Dr. 2004 funded externally by the Arab Health Torab also held membership of this Committee Foundation, and Dr. Torab acted as (2005-08) as well as the Health Informatics Subcommittee members for the consideration Group. Prof. Branicki was also a member of the of various Awards. Prof. Branicki was again Budget and Finance Committee and currently involved as Chair of a Subcommittee for the sits on the Education Advisory Board and Faculty 2006 Awards and Dr.Torab was also involved as Council. Prof. Safi also sat as a member of the a Subcommittee member. Prof. Branicki once Budget and Finance Committee and has been more acted as a Subcommittee Chair for the a member of various committees, including 2008 Awards with Dr. Torab being a Education Advisory Board, Research Grants Subcommittee member. Committee, Promotion Committee, Health and Welfare Committee and the Oncology Research Prof. Derek Younge held nationwide Group, Prof. Branicki and Torab also being responsibilities for theTerry Fox Fund for Cancer members of this Strategic Research Priority Research and was also the Director of the Clinical Group for Oncology. Drs. Fawaz and Fikri are Sciences Course (2005 – 2007) and oversaw members of the Medical Education Research activities of the Al Ain Orthopaedic Club. This Group. Prof. Safi has completed commitments was founded recently and was previously as Coordinator of the Gastrointestinal Module. chaired by Associate Professor Karl Lunsjo, who Dr. Fikri Abu Zidan, also a member of the Medical returned to Sweden in April 2006 after four Informatics Committee, was awarded the successful years in the Department. Prof. Safi and Faculty’s Distinguished Performance Award for Prof. Tjernstrom organized an Oncology Teaching and Research for 2004 and Special Research Day held in Al Ain in November 2005 Endeavours in Human Services Prize at 5th with presentations from holders of Terry Fox Annual Research Conference, April 2004. Cancer Fund awards.

91 Department of Surgery

Continuing Medical Education University and the University of Newcastle Prof. Branicki chaired the Organizing Committee (Northern Institute of Cancer Research). for a highly successful International Conference Speakers from continental Europe came from – Recent Advances in Clinical Oncology Belgium (University of Leuven), France (Hospital Conference which took place in February 2007, Center of Le Havre), Germany (University of Prof.Tjernstrom, Prof. Safi, Prof.Younge and Dr. Heidelberg, University of Leipzig), Italy Torab, Chair of the Sponsorship Committee, also (University of Turin), and Spain (University of being involved in the organization of the Navarra). Invited Faculty also traveled from Conference and its program.This was held in Al Japan (Keio University), Korea (Pohang Ain United Arab Emirates, from February 19-22, University of Science and Technology) and 2007. The meeting was organized by the Australia (University of Queensland). In all, Oncology Research Group, an initiative of the presentations were made by 31 International Faculty of Medicine and Health Sciences at the Overseas Faculty from Australia, Belgium, Canada, France, Germany, Italy, Spain, Japan, Korea, the UK, the USA and regionally from Saudi Arabia and Qatar. Sixteen UAE based speakers participated by invitation from Abu Dhabi (two), Dubai (three), Al Ain (eleven), all being Faculty members at FMHS. This was the largest group of Invited Internationally distinguished clinicians with Oncology interests ever to gather in the UAE.The meeting attracted 1000 delegates from around the world.

The Conference was deemed a great success. Financial assistance to host the meeting came from a variety of sources, substantial support came from the Faculty of Medicine and Health Sciences, UAE University, Tawam Hospital in affiliation with Johns Hopkins Medicine, and the General Authority for Health for Health United Arab Emirates University. The Group Services for the Emirate of Abu Dhabi. We are comprises those with a particular interest in most grateful for the help of many of our Oncology and membership includes basic colleagues in the Oncology Research Group, scientists and clinical faculty at the Faculty of UAE University and Tawam/Johns Hopkins Medicine and Health Sciences (FMHS) and Medicine. Abstracts of Invited Faculty clinicians from Tawam Hospital in affiliation presentations, free papers and posters were with Johns Hopkins Medicine. published in a special supplement of the Emirates Medical Journal [EMJ 2007; Vol 25(1 suppl.)] with the support of the Sheikh Hamdan Foundation. The Proceedings of the meeting Invited Faculty included eminent overseas (Eds: Prof. Branicki, Dr. Saad Aswad, Dr. Fawaz speakers, many of whom are in the forefront Torab, Prof. Abdu Adem) were published in a internationally of their respective fields of volume of the Annals of the NewYork Academy interest. Those emanating from North America of Sciences (Vol 1138) in September 2008 more included clinicians from Johns Hopkins Hospital than 40 chapters (403pp) being included. (Baltimore), MD Anderson Cancer Center (Houston), Memorial Sloan Kettering Cancer The Trauma Group is actively involved in Center (New York), Case Western Reserve planning an international Conference entitled University (Cleveland), the Mayo Clinic ‘Trauma Management, Critical Care and (Rochester), and the University of Toronto Prevention. The above conference will take (Canada). Invited Faculty from the UK came place at the Intercontinental Hotel and Resort from the University of London (St Bartholomew’s at Al-Ain on 17-19 February 2009. The Hospital and University College), Cardiff Conference is an initiative of theTrauma Group

92 Department of Surgery at the Faculty of Medicine and Health Sciences 2005. Studies to measure endotoxin in both (FMHS), United Arab Emirates University and human and rat plasma and sera using the planning for the conference began on 4 Limulus Amoebocyte Lysate Test (LAL) are also February 2007. Prof. Fikri Abu Zidan is the Chair underway. This involves a quantitative of the Organizing Committee, Prof. Branicki spectrophotometric assay for endotoxin in Chair of the Scientific Committee and Dr Fawaz human plasma, modified and standardized for Torab Chair of the Sponsorship Committee. The murine plasma. Dr. Torab is collaborating with scientific program was built on controversial Prof. Ellis (Department of Medicine) and Dr. themes. Parallel sessions will cover four main Ramadi (Department of Microbiology) in an areas: Disaster Medicine, Trauma Management, analysis of the tolerability and efficacy of human Critical Care and Injury Prevention. Four recombinant interleukin II in the management workshops are to be held on 16 February 2009. of sepsis in leukemia patients undergoing These will include ‘hands on training’ in four consolidation chemotherapy. areas: Focused Assesment Sonography of Trauma, Critical Care Ultrasound, Percutaneous Prof. Fikri has a major interest in research Tracheostomy and Establishing a Trauma concerning trauma and has recently presented Registry. initial results following the establishment of The main conference will be three full days. the firstTrauma Registry in the UAE.The project Sixteen well known international experts from has received international attention when North America, Europe, Canada, South Africa, findings have been presented national and Australia and GCC countries have accepted an overseas. Profs. Fikri and Younge collaborated invitation to participate in the conference.This with former colleague Assoc. Prof. Lunsjo in International Conference will provide a forum prospective studies of patients treated in Al Ain for the exchange of ideas and knowledge Hospital having sustained scapular or pelvic concerning trauma management.The meeting fractures. These have come to fruition and are will focus on recent advances and controversies now the two largest prospective series in the through interaction with renowned literature. Prof. Younge is currently writing up international speakers. The conference will be his experiences with novel operative procedures of a multidisciplinary nature as Surgeons, he has devised for the management of Emergency Physicians, Critical Care Physicians, musculoskeletal tumours. Radiologists, Epidemiologists, prehospital staff as well as hospital based medical and nursing Several research projects and activities have staff in the United Arab Emirates and those from been fruitful and these include endotoxin and other GCC are expected to participate. A website cytokine measurement in chemical peritonitis of the conference has been designed with intraperitoneal injection of interleukin 6, http://www.traumaconf.uaeu.ac.ae similar studies in gram positive peritonitis with endotoxin and interleukin 6 injections, as well Research and Scholarship Activity as measurement of endotoxin, interleukin 6 and Dr. Torab is completing studies to evaluate tumour necrosis factor alpha in patients with resorption capacity of inflamed peritoneum in critical limb ischaemia. Studies also involve the the pathogeneses of systemic sepsis in an acute investigation of endotoxaemia and peritonitis model. This work involves inflammatory conditions in patients with measurement of endotoxin and cytokines, the peritonitis and treatment of infection in the gastrointestinal tract being the primary source feet of diabetic patients. of endotoxin as a result bacterial translocation. The work was facilitated by summer electives Prof. Fikri and Dr. Fawaz are Principal undertaken in 2003 and 2004 by female medical Investigators for research projects funded from students at the Faculty. Results were presented different sources – the Research Grants in the GCC Students Conference in January 2004. Committee (Faculty of Medicine and Health One of his supervised students won a poster Sciences) Individual and Interdisciplinary award at the GCC Medical Students Conference Research Proposals (United Arab Emirates held in Kuwait (January 2005). One student also University) and the Sheikh Hamdan Awards. presented the findings, under the supervision More recently, Dr. Torab has been awarded a of Dr. Torab, at a meeting in Germany in March Individual Faculty Research Grant by the UAE

93 Department of Surgery

University for research relating to laparoscopic Articles in Peer- treatment of perforated peptic ulcer. He has also collaborated in studies with Faculty in reviewed Journals Medical Microbiology regarding in vitro investigations of breast cancer. Abu-Zidan FM, Al-Hussona M, Eid HO, Czechowski J. (2008). Massive Associate Professor Fayez Hammad commenced necrotizing fasciitis. J Trauma. research activities in 2008 with two new projects. 64:241. The first of these -“The effect of NSAIDs (nonsteroidal antinflammatory drugs) on the Adam SH, Eid HO, Barss P,Lunsjo obstructed kidney”was supported by a Faculty K, Grivna M, Torab FC, Abu-Zidan FM. (2008). Epidemiology of Seed Grant. The appointment of our research geriatric trauma in United Arab assistant Mr. Loay Lubbad in April 2008, enabled Emirates. Arch Gerontol Geriatr. the commencement of this work. This project 47:377-82. investigates the effect of NSAIDS on the function of the kidney in a rat model of unilateral ureteric Ahmed I, Branicki FJ, Ramadhan K, El-Ashaal Y, Abu Zidan F. (2008). obstruction. The main indicators of renal Pancreatic injuries in the United function being measured in this study are Arab Emirates. Scand J Surg. glomerular filtration rate (GFR), renal blood flow 97(3):243-7. (RBF) and fractional execretion of sodium. GFR and RBF are measured using the clearance of Al Hanaei A, Hefny AF, El Teraifi H, Abu Zidan FM. (2008). Small- inulin and para-aminohippuric acid, respectively. bowel obstruction due to The model has now been established and bilharziasis. Scand J studies commenced with the first group of Gastroenterol. 43:382-3. control animals. The second new project - “Spatial and temporal electrical impulse Botden SM, Torab F, Buzink SN, Jakimowicz JJ (2008). The propagation in the normal and the obstructed importance of haptic feedback ureter” being carried out in collaboration with in laparoscopic suturing training Prof. Wim Lammers from the Department of and the additive value of virtual Physiology was supported by a Faculty Research reality simulation. Surg Endosc. Grant. The project investigates the effect of 22:1214-1222. ureteric obstruction on electrical activities of the Eid HO, Lunsjo K, Chikh Torab F, ureter. We are using small surface probes which Abu-Zidan FM. (2008). Trauma have 160 microelectrodes on the surface to map research in United Arab Emirates: the electrical impulses of the normal and Reality and vision. Sing Med J. 49 obstructed ureter.The work is almost in its final (9):1-5. stages and an abstract has been accepted for Eid HO, Hefny AF, Joshi S, Abu- presentation in the Annual meetings of both Zidan FM. (2008). Non traumatic the American Urological Association and the perforation of the small bowel. European Association of Urology. Afr Health Sci. 8: 36-39 Departmental research interests are thus diverse, El-Ashaal YI, Al-Olama AK, Abu- currently encompassing general surgery, Zidan FM. (2008). Trans-anal oncology, ophthalmology, trauma and urology. rectal injuries. Singapore Med J. Dr. Mahmoud has ongoing research 49:54-6. collaboration in Canada in Ophthalmology. As the Department grows in stature with a new Hammad FT. (2008). Radical Prostatectomy, Oncological medical laboratory specialist in post to act as Outcomes, Annals of New York laboratory manager and surgeons with Academy of Sciences, 1138: subspeciality interests, it is perceived that 267–277. experimental research initiatives will expand in keeping with strategic themes which have Hefny AF, Eid HO, Salim K, Abu- Zidan FM. (2008). Medical image. been adopted in the Faculty. Fatal tyre blast injuries including

94 Department of Surgery bowel evisceration and forearm Complete Blunt Renal Artery amputation. N Z Med J.121:72-3. Published Occlusion in Multiple Trauma Abstracts,letters Patients. ANZJ Surg 2008, 78 Hefny A.F., Ahmed I, Branicki F.J., (Suppl 1): A147(TS44P) Ramadan K, Czechowski J, Abu- Correspondence Zidan F.M. (2008). Management of Rahman M, Abu-Zidan F, IbrahimY, Abu-Zidan FM, Eid H, Masoud B, Mesenteric Vascular Occlusion. Abuhasna S. (2008). Care of Branicki FJ. (2008). Camel bite Singapore Med J, 49(4):316-9. terminally ill patients: an opinion injuries: a six year prospective survey among healthcare study of 33 patients. ANZJ Surg Jawas A, Abu-Zidan FM. (2008). providers in the Middle East. 2008, 78 (Suppl 1): A145(TS37P) Management algorithm for Critical Care 12 (Suppl 2):519. complete blunt renal artery Abu Zidan FM, El-Houni A, Al- occlusion in multiple trauma Ayyan M, Faour I, Neidl van patients: case series. Int J Surg. Gorkom K, El-Taji H. (2008). k 6:317-22. Adrenal Insufficiency following Blunt Abdominal Trauma: Report Oulaqi NS, Hefny AF, Joshi S, Salim of two Cases and Review of the K, Abu Zidan FM. (2008). Literature. ANZJ Surg 2008, 78 Proceedings, Endometriosis of the appendix. (Suppl 1): A145(TS35P) Invited lectures Afr Health Sci; 8: 196-198. Al-AshaalY, Joshi S,Tjenstrom NO, and Others Saleh A, Potemkowski A, Abu- Abu-Zidan FM. (2008). Papillary Zidan FM. (2008). Endovascular Abu Zidan FM, El-Houni A, Al- thyroid carcinoma presenting as aortic stent graft repair for blunt Ayyan M, Faour I, Neidl van a lateral neck cyst. ANZJ Surg 2008, traumatic thoracic aortic Gorkom K, El-Taji H. (2008). 78 (Suppl 1): A46(ES25P) transection. Sing Med J. 49:847- Adrenal Insufficiency following 8. Blunt Abdominal Trauma: Report Branicki FJ, Ahmed I, Ramadan K, of two cases and review of the Al-AshaalY, Abu-Zidan FM (2008). Tadros AM, Lunsjo K, Czechowski literature. Royal Australasian Pancreatic injuries in United Arab J, Abu-Zidan FM. (2008). Causes of College of Surgeons and the Emirates. ANZJ Surg, 78 (Suppl 1): delayed diagnosis of scapular College of Surgeons of Hong Kong A140(TS11) fractures. Injury. 39:314-8. Conjoint Annual Scientific Congress, Hong Kong, China. Eid HO, Adam SH,Torab FC, Lunsjo Torab F.C., Bokobza B., Branicki K, Barss P, Michal Grivna M, Abu- F.J. (2008). Laparoscopy in Abu-Zidan FM, Eid H, Masoud B, Zidan FM. (2008). Factors affecting Gastrointestinal Malignancies. Branicki FJ. (2008). Camel Bite mortality in motor vehicle Annals of New York Academy of Injuries: a six year prospective collisions in Al-Ain City. ANZJ Surg Sciences, 1138:155-61. study of 33 patients. Royal 2008, 78 (Suppl 1): A146(TS41P) Australasian College of Surgeons and the College of Surgeons of k Eid HO, Lunsjo K,Torab FC, Barss P, Hong Kong Conjoint Annual Grivna M, Abu-Zidan FM. (2008). Scientific Congress, Hong Kong, Pre-incident behavior and China. mechanism of injury in drivers Books, Chapters, involved in vehicle collisions in Abu-Zidan FM, Barss P. (2008). United Arab Emirates. ANZJ Surg Occupational Injury Prevention. Reviews and 2008, 78 (Suppl 1): A143(TS24P) Trauma and Accident and Editorials Emergency Conference, Abu- Hammad F, Kaya M, Kazim E. Dhabi, UAE. (2008). Extracorporeal Shockwave FJ Branicki, S. Aswad, F.C.Torab, A, lithotripsy: another confirmation Abu-Zidan FM. (2008). Damage Adem, Eds. Recent Advances in of its efficiency in children. Control Surgery. Second Emirates Clinical Oncology. Annals of the European Urology. 7 (3): 82. Emergency Surgery and Trauma New York Academy of Sciences, Conference. Fujairah, UAE. September 2008, Vol 1138, pp 403. Hefny AF, Eid HO, Abu-Zidan FM. Published by Blackwell Publishing (2008). Severe tyre blast injuries Abu-Zidan FM, Branicki FJ, Torab on behalf of the New York during servicing: report of three FC , Albarracin F, Kazim S, Gautam Academy of Sciences. ISBN 978-1- cases and review of the literature. SC (2008). Advanced Trauma Life 57331-700-9 ANZJ Surg 2008, 78 (Suppl 1): Support Courses in the United A147(TS49P) Arab Emirates. 9th College of Surgeons of East, Central and k Jawas A, Abu-Zidan FM. (2008). Southern Africa (COSECSA) / 59th Management Algorithm for Association of Surgeons of East

95 Department of Surgery

Africa (ASEA) Annual General Conference of Laparo-endoscopic Association of Urology. Milan, Italy. Meeting and Scientific Conference. Surgery. Emirates Medical Maputo, Mozambique. Association. Dubai, UAE. Hefny AF, Eid HO, Abu-Zidan FM. (2008). Severe tyre blast injuries Ahmad I, Branicki FJ, Ramadhan K, Branicki FJ. (2008). Pancreatic during servicing: report of three El-AshaalY, Abu-Zidan FM. (2008). Injuries in the United Arab cases and review of the literature. Pancreatic injuries in the United Emirates. Royal Australasian Royal Australasian College of Arab Emirates. 9th College of College of Surgeons and the Surgeons and the College of Surgeons of East, Central and College of Surgeons of Hong Kong Surgeons of Hong Kong Conjoint Southern Africa (COSECSA) / 59th Conjoint Annual Scientific Annual Scientific Congress. Hong Association of Surgeons of East Congress. Hong Kong, China. Kong, China. Africa (ASEA) Annual General Meeting and Scientific Conference. Branicki FJ. (2008). Pancreatic Hefny AF, Ahmed I, Branicki FJ, Maputo, Mozambique. injuries, Al Ain experience. 2nd Ramadan K, Czechowski J, Abu- Emirates Emergency Surgery and Zidan F.M. (2008). Management of Al-AshaalY, Joshi S,Tjenstrom NO, Trauma Conference. Fujairah, UAE. Mesenteric Vascular Occlusion. 9th Abu-Zidan FM. (2008). Papillary College of Surgeons of East, thyroid carcinoma presenting as Branicki FJ. (2008). Gastric Cancer- Central and Southern Africa a lateral neck cyst. Royal from minimal access to (COSECSA) / 59th Association of Australasian College of Surgeons multimodality therapy. 9th College Surgeons of East Africa (ASEA) and the College of Surgeons of of Surgeons of East, Central and Annual General Meeting and Hong Kong Conjoint Annual Southern Africa (COSECSA) / 59th Scientific Conference. Maputo, Scientific Congress. Hong Kong, Association of Surgeons of East Mozambique. China. Africa (ASEA) Annual General Meeting and Scientific Conference. Jawas A, Abu-Zidan FM. (2008). Branicki FJ. (2008). Management Maputo, Mozambique. Management algorithm for of early Complications following complete blunt renal artery Gastro-duodenal Surgery. 7th Eid HO, Adam SH,Torab FC, Lunsjo occlusion in multiple trauma International Surgical Update. K, Barss P, Michal Grivna M, Abu- patients. Royal Australasian Royal Hospital Muscat and Omani Zidan FM. (2008). Factors affecting College of Surgeons and the Chapter of the Royal College of mortality in motor vehicle College of Surgeons of Hong Kong Surgeons of Edinburgh. Muscat, collisions in Al-Ain City. Royal Conjoint Annual Scientific Oman. Australasian College of Surgeons Congress, Hong Kong, China. and The College of Surgeons of Branicki FJ. (2008). Barrett’s Hong Kong Conjoint Annual Jawas A, Abu-Zidan FM. (2008). oesophagus – medical, endoscopic Scientific Congress, Hong Kong, Management algorithm for or laparoscopic intervention? 7th China. complete blunt renal artery International Surgical Update. occlusion in multiple trauma Royal Hospital Muscat and Omani Eid HO, Lunsjo K,Torab FC, Barss P, patients. 7th International Chapter of the Royal College of Grivna M, Abu-Zidan FM. (2008). Symposium on Vascular Surgery Surgeons of Edinburgh. Muscat, Pre-incident behavior and Update, Riyadh, Saudi Arabia. Oman. mechanism of injury in drivers involved in vehicle collisions in Jawas A, Abu-Zidan FM. (2008). Branicki FJ. (2008). Gastric Cancer: United Arab Emirates. Royal Management algorithm for Case presentation and Moderator Australasian College of Surgeons complete blunt renal artery Panel Discussion. Decision Making and The College of Surgeons of occlusion in multiple trauma in Oncology: Evidence and Hong Kong Conjoint Annual patients. 6th Gulf Heart Consensus. National Scientific Congress. Hong Kong, Association Conference, Sana’a, Comprehensive Cancer Network China. Yemen. (NCCN). 1st Annual Asia and Middle East Guidelines in Hammad FT, Hani O Eid, F Abu- Shobhana PK, Nair D, AlMahmoud Oncology Symposium. Al Ain, UAE. Zidan. (2008). Epidemiology of T, Azeem A, Moh’d AA, Al-Shamsi H. genitourinary injuries following (2008). Visual out come of ocular Branicki FJ. (2008). Gastric Cancer road traffic collisions: a study from trauma in camel hit and robot Surgery. Proceedings: Cleveland the Middle East. 2nd Emirates jockey hit injuries. World Clinic Surgical Symposium. Emergency Surgery and Trauma Ophthalmology Congress (WOC). Advances in Surgery. Abu Dhabi, Conference, Fujairah, UAE. Hong Kong. UAE. Hammad FT, Kaya M, Kazim E Torab FC, (2008). Is type II Diabetes Branicki FJ. (2008). (2008). Extracorporeal shockwave now a surgical disease? Arab Gastroesophageal reflux disease lithotripsy: another confirmation Health Conference. Dubai, UAE. – medical, endoscopic or surgical of its efficiency in children. 23rd intervention. 2nd International Annual Meeting European Torab FC. (2008). Is type 2 diabetes

96 Department of Surgery

a surgical disease? 13th Annual Congress of the International Workshop on Diabetes Mellitus Federation for the Surgery of Research Grants and its Complications. Al Ain, UAE. Obesity and Metabolic Diseases, FMHS NEW Research Grant Buenos Aires, Argentina. Dr F Hammad (PI), Prof W Lammers, Torab FC. (2008). Bariatric Surgery. Ms B Stephen, Mr L Lubbad. 2nd International Conference of Torab FC. (2008). Obesity surgery Spatial and Temporal electrical Emirates Society of Laparo- in a country of high prevalence of impulse propagation in the normal Endoscopic Surgeons. Dubai, UAE. obesity and diabetes. International and the obstructed ureter. Surgical Week 2007. Montréal, Torab FC. Fardoun A, Branicki F. Canada. (2008). Results of laparoscopic gastric banding versus bypass in a k country with high prevalence of k obesity and diabetes. XII World

Standing left to right: Mr. Abdulla Jamal, Mr. Loay Lubbad, Dr. Fayez Hammad, Dr. Zuhair Al Fardan, Mr. Cherukunnummal Aboobacker Seated left to right: Ms. Mahra Al Mansouri, Ms. Reesa Al Mansouri, Prof. Frank Branicki, Dr. Fawaz Torab, Dr. Ali Al Beloushi, Prof. Fikri Abu Zidan Absent: Prof. Farouk Safi, Dr. Ali Jawas, Dr. Saeed Al Thani, Dr. Tahra Mahmoud 2008Surgery

http://www.fmhs.uaeu.ac.ae/Departments/Surgery Tel: 7137558 / Fax: 7672067

97

Research Priority Groups 100 Diabetes and Cardiovascular Research Priority Group

Annual Report

Introduction Core members: Prof. Enyioma Obineche Aims of the Group Dr. Hussain Saadi Facilitate diabetes and cardiovascular research in the Faculty. Prof. Abdu Adem Enhance the clinical and basic research capabilities of established diabetes investigators. Prof. Chris Howarth Act as a channel for research funding. Prof. El-sadig Kazzam Act as a resource for new faculty members and for those who may Prof. Farouk Safi want to start research in diabetes/cardiovascular diseases. Dr. Juma Al Kaabi Present scientific research at national and international scientific Prof. Thomas Adrian conferences. Dr. Fatma Al Maskari Publish scientific research in national and international scientific Dr. Syed Mehboob Ali Shah journals. Prof. Ernest Adeghate Cooperate and liaise with any local, national or international (Chair) agency with similar research interests. Train post-doctoral, doctoral, masters and bachelors degree In addition to the core students. members, group membership Act as a resource unit on diabetes and cardiovascular diseases. includes 40 other faculty members from within the Activities FMHS.

Annual Workshop on Diabetes Mellitus and Its Complications, March 22, 2008 The DCRG organized a one-day Annual Workshop on Diabetes Mellitus and Its Complications on Saturday, March 22, 2008 at the Faculty of Medicine & Health Sciences, United Arab Emirates University. The Workshop attracted more than 400 delegates across the UAE and abroad. The Workshop covered different areas of diabetes including New Treatment options for Type 2 Diabetes, Hypertension in Diabetes: A double jeopardy and Assessment of Physical Activity and Dietary Practices among Diabetic Patients in Al-Ain District Diabetes and Cardiovascular

Themes of research include the Exercise-induced remodelling of diabetic following cardiomyopathy in STZ-induced diabetic rats. Neuropeptides and neurotransmitters in UAE University Interdisciplinary Grant (Howarth diabetes FC, Adeghate E) Trace elements in diabetes Immunology of diabetes Impairment of cellular redox and respiratory Clinical pharmacology of diabetes functions by acetaminophen: role of oxidative Insulin and glucagon secretion stress and glutathione metabolism in the Effects of diabetes on cardiac muscle function prevention of toxicity by antioxidants. FMHS Epidemiology of diabetes (Raza H) Diabetic complications (nephropathy, neuropathy and angiopathy) High prevalence of rickets and sub-clinical Lipids in human and experimental diabetes maternal and childhood vitamin D deficiency in Metabolic syndrome and obesity the Middle East: a randomized controlled trial Pancreas transplantation of prenatal vitamin D supplementation to Hypertension prevent vitamin D deficiency in mothers and Gestational diabetes their infants.TheThrasher Research Fund (USA) $377,974. (Saadi H) Grants obtained by members National strategy for Environment and Health in Release of rectal hormones for weight loss and the United Arab Emirates. The Environment improvement of type 2 diabetes mellitus Agency of Abu Dhabi. 5 million USD. 2008 (Aw Externally funded project (Adrian T, Saadi H). TC, Al-Maskari F, Schneider J, El-Sadig M and Faculty of Public Health, University of North Effect of pancreatic beta cell transplantation Carolina Chapel Hill) on the metabolic parameters of diabetic rats. Shekh Hamdan Award for Medical Sciences Parents Assisting Children andTeachers (PACT) (Adeghate E) for obesity Prevention. One Year. Individual grant. UAE University. 2008 (Shah SM, Al-Maskari The effect of visfatin and adiponectin on FandBernsenR). metabolic parameters of an animal model of type 2 diabetes. UAE University Individual Grant Altered gene expression of ion transport (Adeghate E) proteins underlies ventricular arrhythmias in alloxan-induced non-insulin-dependent The effect of incretin on gene expression in diabetic rats. UAE University Individual Grant pancreatic islet cells in diabetes mellitus. UAE (Howarth FC) University Individual Grant (Adeghate E)

Remodelling of ion transport proteins underlies Collaboration with local and abnormal electrical conduction in the international institutions streptozotocin-induced diabetic rat heart. FMHS Local Project Grant (Howarth FC) Al Ain Diabetes Research Group Emirates Diabetes Society (Emirates Medical Progressive effects of type 2 diabetes mellitus Association) on heart function in the Goto-Kakizaki rat. FMHS Tawam and Jimi Hospitals, Al Ain, UAE (Howarth FC, Adeghate E) Neuroscience Research Group, FMHS, UAEU Faculty of Science, UAEU Sinoatrial node dysfunction in the Faculty of Engineering, UAEU streptozotocin-induced diabetic rat heart, UAE International University Individual Grant (Howarth FC) University of Manchester, UK

102 Diabetes and Cardiovascular

James Cook University, Queensland, Australia reviewed journals including but not limited to University of Bristol, UK Annals of New York Academy of Sciences, BMC University of Leeds, UK Nephrology, Chemical Biology & Drug Design, University of Central Lancashire, UK Clinical Immunology, Current Medicinal Karolinska Institut, Sweden Chemistry, Diabetes Research and Clinical Semmelweis University, Hungary Practice, Endocrine Practice, Experimental CNRS, France Physiology, Gynecological & Obstetrics Investigation, Molecular and Cellular Future plans Biochemistry, Peptides, Peritoneal Dialysis The group is planning to establish a Diabetes International, Reviews in Diabetes Studies, The Research Centre.The centre will provide a facility Endocrinologist, Toxicology and Applied that enables and facilitates a multidisciplinary Pharmacology in 2008. The cumulative impact approach to the study of diabetes and its factors of these journals exceeded 79 (See complications and to provide the infrastructure Departments of Anatomy, Biochemistry, for diabetes related undergraduate and post- Community Medicine, Pathology, Pharmacology, graduate research and teaching activities. Physiology, Psychiatry, Internal Medicine and Medical Microbiology for relevant publications). Publications Members of the DCRG published more than 36 diabetes-related papers in top quality peer-

A B

Glutamic acid decarbioxylase (GAD)-positive cells are present in normal Goto-Kakizaki rat (A). Some GAD-positive (green) cells co-localize with insulin-positive cells (red) in pancreatic islets (B).

103 Genetics and Development Research Group

Annual Report

Mission of the Group The UAE is a young modern society, with traditional customs and beliefs, in which consanguineous marriages are still the norm. As a result, autosomal recessive disorders occur more frequently in the UAE than in other populations with over 150 recessive disorders having been reported so far. In addition, the local population has a high frequency of alpha and beta thalassemia mutations and hemoglobin S. Furthermore, the incidence of multifactorial diseases such as type 2 diabetes, obesity, certain cancers, neurodegenerative and cardiovascular diseases has been steadily rising in the UAE over the past three decades.This is mainly due to the rapid socioeconomic growth and a significant rise in life expectancy. The rapid increase in the prevalence of multifactorial diseases also suggests genetic predisposition to those diseases revealed by rapid changes in lifestyle and diet. The mission of the Genetics and Development Research Group is to conducts the highest quality research into the basis of genetic diseases and provide high quality health care and education. In support of its mission, the group strives to (1) define the extent of genetic, developmental and multifactorial disorders in the country; (2) be the leading source of research into the causes and pathogenesis of these disorders; and (3) to seek new approaches to diagnosis, treatment and prevention of such disorders. Our mission is also to educate the next generation of health care leaders by providing continuing professional development to physicians with up to date courses and to educate the public by providing information on different genetic disorders and approaches to prevention. The Group Principal Investigators Principal investigators members of the Genetics and Development Research Group are affiliated to different departments within the Faculty of Medicine and Health Sciences Genetics and Development

of the UAE University. The current membership Research interest: The roles of Akt signaling in of the group is: the mechanisms of cancer

Dr. Bassam R Ali Dr. Salim Bastaki (Pharmacology and (Pathology Department); Associate Professor Therapeutics Department); Associate Professor of Molecular Genetics and Leader of the Research interests: 1) Oxidative phenotyping Genetics and Development Research Group. and genotyping UAE nationals using Research interests: (1) Elucidation of the antidepressant drugs 2) Teratogenic effects of molecular defects responsible for genetic antiepileptic drugs in collaboration with disorders in the UAE and Arab populations; (2) Professor Abdulrazzaq. Development of molecular diagnostics for mutations underlying genetic diseases Dr. Srdjan Denic (Internal Medicine Depart- prevalent in Arab populations and (3) ment); Associate Professor Establishing the cellular mechanisms of genetic Research interests: (1) Effect of human disorders. inbreeding on selection of alpha-thalassemia (2) The genetics of neutropenia Prof. Yousef M Abdulrazzaq (Paediatrics Department); Professor Dr. Omar M El-Agnaf (Biochemistry Depart- Research interests: (1) The genetics of truncus ment); Associate Professor arteriosus (2) Metabolic disorders (3) Birth Research interest: The role of protein misfolding defects with vigabatrin, lamotrigine and and aggregation in neurodegenerative diseases gabapentin and (4) Aflatoxin effects on the fetus. Dr. Sehamuddin Galadari (Biochemistry Department); Associate Professor and Associate Prof. Thomas E Adrian (Physiology Depart- Dean for Research ment); Professor and Chair of Physiology Research interest: Cell signaling and human Research interests: Identification of diabetes disease susceptibility genes in UAE nationals. Prof. Mohammad Y Hassan (Pharmacology Prof. Lihadh Al-Gazali (Paediatrics and Therapeutics Department); Professor and Department); Professor and Senior Consultant Vice Dean of Faculty of Medicine and Health in Clinical Genetics Sciences Research interests: Delineation of the clinical Research interest: The roles of neurotransmitters and molecular aspects of congenital in diabetes, epilepsy, aging and neuro- malformations in the UAE. degenerative diseases

Dr. Ahmad Hassan Al-Marzouqi Prof. Ruth Langer (Radiology Department); (Biochemistry Department); Assistant Professor, Associate Dean for Clinical Affairs Professor and senior consultant Radiologist Research interest: Protein complexes that modify chromatin for transcription regulation Prof. Miodrag Lukic (Medical Microbiology Department); Professor, Chair of Medical Dr. Suhail Al-Salam (Pathology Department); Microbiology Assistant Professor Research interests: Molecular pathology of Dr. Hisham Mirghani (Obs/Gyne Department); cancers in UAE Associate Professor

Dr. Samir Attoub (Pharmacology and Dr. Hassib Narchi (Paediatrics Department); Therapeutics Department); Assistant Professor Associate Professor

105 Genetics and Development

Research interests: Causes and mechanisms of factors play a major role in the etiology of most common diseases in Middle Eastern health problems affecting Middle Eastern populations populations. According to the March of Dimes Survey of 2006, most Middle Eastern countries Prof. Tahir A Rizvi (Medical Microbiology have the highest rates of birth defects in the Department); Professor world, mainly due to genetic causes. In addition, Research interest: Retroviral/lentiviral vectors common diseases with clear genetic for human gene therapy. predispositions such as diabetes, cancer and age-related diseases are on the increase Dr. Hussain Saadi (Internal Medicine Depart- worldwide. Therefore, a detailed understanding ment); Associate Professor and Senior of the genetic basis of birth defects, as well as Consultant Endocrinologist common diseases, is essential for the Research interest: The genetic causes of development of better diagnosis, treatment common diseases in UAE and Arab populations and prevention strategies. The conference programme was focused on both the molecular Group activities for 2008 and cellular basis of those diseases and the Most of the group activities for this year have applications of new technologies and been focused on organizing the 2nd Al-Ain knowledge, gained through extensive research, International Genetics Conference, 28-30th for the benefit of the scientific community and October 2008. The conference was held under patients. The organizing and scientific the patronage of His Excellency Sheikh Nahayan committees of the conference have set the Mabarak Al Nahayan, Minister of Higher following aims: Education and Scientific Research and 1.To disseminate recent research findings in Chancellor of the UAE University. The inaugural human genetics among local, regional and address was delivered by Her Excellency Dr. international scientists and clinicians with a Fatima Al Shamsi, the UAE University Secretary focus on the applications and molecular General stressing the importance of genetics mechanisms research to the UAE society. The opening 2. To promote interactions between geneticists ceremony and the first session were held at and healthcare workers in the UAE and the FMHS building and the rest of the conference region for the benefit of families affected by at Al-Ain Rotana Hotel. The relevance of the genetic diseases conference is based on the fact that genetic 3.To promote the practice of genetic

106 Genetics and Development

diagnostics and genetic counseling among and CNRS in France on the genetics of type 2 healthcare workers to reduce the occurrence diabetes, a disease that affect over 30% of the of new cases of genetic diseases UAE adult population. The conference ended 4.To create opportunities for collaborative with closing remarks by Prof. S. George research activities between scientists in the Carruthers, the conference president and the UAE with regional and international leading Dean of the Faculty of Medicine and Health scientists in the field Sciences.

To fulfill these objectives, the conference Scientific programme of the conference: committees assembled a three-day scientific 33 Invited speaker presentations (see the list programme in the form of plenary lectures, below) symposia, workshops, oral and poster 12 Oral presentations selected from submitted presentations covering a wide variety of themes abstracts (out of 118 received) such as the genetics of diabetes, obesity, 8 Workshop presentations osteoporosis, cancer, cardiovascular and skin 98 Poster presentations diseases as well as the genetics of congenital Invited Speakers at the conference: malformation and mental retardation. During Prof. John Hardy, University College London, UK the three day conference, over 30 outstanding Prof. Philippe Froguel, Imperial College London, international and regional leaders in the field UK, and CNRS, France of human genetics delivered their latest Dr. Joseph G. Gleeson, San Diego, USA scientific findings. In addition, several sessions Dr. I. Sadaf Farooqi, Cambridge University, UK and workshops were devoted to the genetic Prof. Serge Ferrari, Geneva University, diseases prevalent in Middle Eastern countries Switzerland including prevention and genetic counseling Dr. J. Clay Stephens, Motif BioScience, USA approaches. The speakers came from Prof. Stephen B. Liggett, University of prestigious international and regional Maryland School of Medicine, USA institutions. The opening session started with Dr. C. Geoff Woods, Cambridge University, UK remarks on the importance of genetics and Prof. Christopher A. Walsh, Harvard Medical genomics research by Professor Christopher A. School, USA Walsh from Harvard Medical School and the Dr. Berthold Streubel, Medical University of opening lecture was delivered by Professor Vienna, Austria Philippe Froguel from Imperial College London Prof. Christine Mannhalter, Medical University

107 Genetics and Development

of Vienna, Austria King Faisal Specialist Hospital and Research Dr. Kathleen Barnes, Johns Hopkins, USA Center, Saudi Arabia Prof. Gary Cutting, Johns Hopkins, USA Prof. M. Elizabeth Ross, Weill Cornell Medical International collaborations College, New York, USA • International Clearing House for Birth Defect Prof. Nabil G. Seidah, Montreal, IRCM, Canada Monitoring System [member] Prof. Peter Bruade, King’s College London, UK • Harvard University Prof. John A. McGrath, King’s College London, UK • University of California, San Diego Dr. Raghu Kalluri, Harvard Medical School, USA • Cambridge University, UK Prof. Hossein Najmabadi, Genetics Research • Birmingham University, UK Center, Tehran, Iran • Imperial College London Dr. Moien Kanaan, Bethlehem University, • University College London Medical School Palestine • National Human Genome Research Institute Dr. Tawfeg Ben-Omran, Weill Cornell Medical • National Institute of Health, Bethesda, USA College in Qatar, Qatar • Institute of Human Genetics, Erlangen, Dr. Hatem El-Shanti, Shaffalah Center, Qatar Germany Dr. Moeen Al-Sayed, Kingdom of Saudi Arabia • Mount Sinai School of Medicine, New York Dr. Said Al-Yahyaee, SQU, Sultanate of Oman • Telethon Institute of Genetics and Medicine Dr. Erol Baysal, Dubai Genetic Center, UAE Naples, Italy Dr. Ghazi Tadmouri, Center for Arab Genomic • UT Southwestern Medical Center at Dallas, USA Studies, UAE • Institute fur Medizinische Genetik, Berlin, Prof. Lihadh Al-Gazali, UAE University, UAE Germany Dr. Omar El-Agnaf, UAE University, UAE • Cincinnati Children’s Hospital, OH, USA Dr. Srdjan Denic, UAE University, UAE • University of Ottawa, Canada Dr. Hussein Saadi, UAE University, UAE • Medical University of South Carolina, Dr. Bassam Ali, UAE University, UAE Charleston, South Carolina

Conference attendance: Grants and Publications Total attendees including delegates, speakers, Refer to departmental reports for individual organizers and sponsors over the three day members of the group. period was 394 (our target was 250-300). Genetics Diagnosis and Counseling Workshop Other major achievements in 2008 was attended by over 75 delegates (our target The Genetics and Development Research was 50-60). Priority group members led the application for the establishment of a research center of Collaborations of the group members excellence in “Genes and Diseases” from the with UAE, regional and international newly established National Research organizations Foundation. The total fund approved by NRF is 37.5 million AED over five year period. Prof. Local collaborations Lihadh Al-Gazali was the principal applicant • Ministry of Health and the co-applicants were: Professors Basel • School Health Authorities al-Ramadi, Thomas Adrian and Ernest Adeghate • Sheikh Hamdan Awards for Medical Sciences and Drs Omar El-Agnaf and Bassam Ali. • Center for Arab Genomic Studies • Central Veterinary Research Laboratory (pictures are from the various activities of the 2nd Al-Ain International Genetics Conference). Regional collaborations Sultan Qaboos University, Muscat, Sultanate of Oman

108 The Immunoregulation and Infection Research Group

Group Leader: Annual Report Prof. Basel al-Ramadi Dept. of Microbiology & Immunology Core Members: Prof. Miodrag L. Lukic Dept. of Microbiology & Immunology Prof. Senarath Dissanayake Dept. of Microbiology & The main aim of the Immunoregulation and Infection Research Immunology Priority Group is to promote basic and clinical research in the Prof. Michael Ellis Dept. of Internal Medicine fields of immunology, microbiology, and related disciplines. Prof. S. Uduman Through its wide membership, which encompasses investigators Dept. of Paediatrics in a diverse number of departments in the Faculty of Medicine Prof. J. Michael Conlon and Health Sciences and affiliated hospitals, the Group aims to Dept. of Biochemistry facilitate inter-departmental collaborations in basic and clinical Prof. Tahir A. Rizvi Dept. of Microbiology & research broadly related to immunological disorders, infectious Immunology diseases, and microbial pathogenesis.The group also undertakes Prof. Tibor Pal sponsorship of international and regional visitors and speakers Dept. of Microbiology & to FMHS and periodically becomes responsible for organizing Immunology international medical scientific conferences. Dr. Walter Conca Dept. of Internal Medicine Dr. Eric Mensah-Brown I. Original Publications by Group Members in Dept. of Anatomy the year 2008 Dr. Gulfaraz Khan Publication details of the members of the Immunoregulation and Dept. of Microbiology & Infection Research Priority Group can be found under their Immunology Dr. Maria J. Fernandez- respective FMHS departments. Cabezudo Dept. of Biochemistry II. Sponsored Events Dr. Suleiman Al-Hammadi 1. The Third International Immunology Meeting Dept. of Paediatrics The major event during 2008 which occupied much of the group Dr. Mariam Al-Shamsi Dept. of Microbiology & members’ time was the hosting of the 3rd Al-Ain International Immunology Immunology Meeting, held under the title "Immunoregulation Dr. Fawaz Chikh Torab in Chronic Inflammatory Disorders" over the period 17-20 March Dept. of Surgery 2008. The meeting was held under the patronage of HE Sheikh Dr. Suhail A. Al-Salam Nahayan Mabarak Al Nahayan, Minister of Higher Education Dept. of Pathology Dr. Ahmed Al-Qahtani and Scientific Research and Chancellor of the UAE University, and Dept. of Microbiology & represented the third in a series, the first two having been held Immunology in 1993 and 2002 in Al-Ain, United Arab Emirates. The meeting Dr. Ahmed Al-Suwaidi was organized under the umbrella of the International Union of Dept. of Paediatrics Immunological Societies and was supported by Nature Dr. Agnes Sonnevend Dept. of Microbiology & Immunology, the premium scientific journal in the field.Twenty Immunology Immunoregulation and Infection

eight international speakers from the USA (Dr. more than 30 countries in North America, South David A. Brenner, University of California San America, Europe, Asia and Africa. Diego, San Diego; Dr. Richard A. Flavell, Yale University School of Medicine, New Haven; Dr. Meeting Report Giorgio Trinchieri, National Cancer Institute, A report on the meeting was commissioned by Bethesda; Dr.Yang Liu, University of Michigan Nature Immunology. The report summarized Health System, Ann Arbor; Dr. Ruslan the major scientific findings discussed during Medzhitov,Yale University School of Medicine, the conference. The meeting report was New Haven; Dr. Emad Alnemri, Thomas published in the July 2008 issue of Nature Jefferson University, Philadelphia; Dr. Noel Rose, Immunology and was accompanied by a short Johns Hopkins Bloomberg School of Public editorial praising the positive steps taken by Health, Baltimore; Dr. Hamid Rabb, Johns the UAE authorities in promoting the culture Hopkins University School of Medicine, of scientific inquiry. Baltimore; Dr. Paolo Casali, University of California, Irvine; Dr. Yuri Sykeluv, Thomas {Ref: Basel al-Ramadi, Adrian Hayday, and Jefferson University, Philadelphia; Dr. Zacharie Wilhelm Schwaeble. Immunology in the Arabian Brahmi, Indiana University School of Medicine, desert. Nature Immunology 9:699-703, 2008}. Indianapolis; Dr. Mercedes Rincon, University of Vermont, Burlington), the UK (Dr. Adrian Meeting Proceedings: Special Issue of Clinical Hayday, King's College London, London; Dr. Immunology Foo Y Liew, University of Glasgow, Glasgow; A special, regular, issue of the journal Clinical Dr. Fiona Powrie, University of Oxford, Oxford; Immunology, will be devoted for the publication Dr. Graham A. W. Rook, University College of selected reviews and original articles London, London; Dr. Wilhelm Schwaeble, contributed by invited speakers at the University of Leicester, Leicester), Switzerland Dr. conference.The journal Clinical Immunology is Marc Y Donath, University Hospital Zürich, the official journal of the USA-based "Clinical Zurich, France Dr. Salem Chouaib, Institute Immunology Society" and has an impact factor Gustave-Roussy, INSERM, Paris, France; Dr. of 3.6. The special edition was published in Pierre Miossec, Hopital Edouard Herriot, Lyon), January 2009 under the guest editorship of Prof. Australia (Dr. Leonard C Harrison, The Walter Basel al-Ramadi and Prof. Miodrag Lukic. and Eliza Hall Institute of Medical Research, Melbourne), Germany (Dr. Martin Herrmann, 2. Sponsored Events – cont. University Hospital Erlangen, Erlangen), Austria The following international speakers were (Dr. Hannes Stockinger, Medical University of hosted by the Immunoreglation and Infection Vienna, Vienna),Tunisia, (Dr. Ridha Barbouche, Research Priority Group during 2008. University of Tunis, Tunisia), Finland (Dr. Malcolm Richardson, University of Helsinki, February 13, 2008 Helsinki), India (Dr. Narinder Mehra, All India Prof. Andrew Lever Institute of Medical Sciences, New Delhi), Brazil Professor of Infectious Diseases (Dr. Jorge Kalil University of Sao Paulo, Sao Director Addenbrooke’s Hospital, University of Paulo) and Egypt (Dr. Ahmed El Gohary,Suez Cambridge, UK Canal University, Cairo) participated in the Title of Presentation: conference. In addition, 15 local speakers from “HIV and its Relatives: Turning Molecular and FMHS, Tawam hospital, and Department of Structural Biology to Clinical Use" Preventive Medicine participated in the conference. All in all, a total of 58 plenary April 16, 2008 seminars, 18 short talks and 89 posters were Prof. Bared Safieh-Garabedian presented during the conference. The number Professor of Neuroimmunology of registrants for the meeting was 423 from American University of Beirut, Lebanon

110 Immunoregulation and Infection

Title of Presentation: “Neuroimmune Role and Anti-inflammatory Actions of Thymulin”

June 2, 2008 Professor Hannes Stockinger Chair, Department of Molecular Immunology, Medical University of Vienna, Austria Title of Presentation: “Differentiation Factors of Regulatory T cells”

November 3, 2008 Professor Janko Nikolich-Zugich MD, Ph.D. Chairman, Department of Immunobiology, Bowman Professor in Medical Research College of Medicine, University of Arizona, USA. Title of Presentation: “Detecting and fixing the age-related defects in T-cell immunity”

111 Medical Education Research Group

Annual Report

Mission of the Group To act as a co-ordinating body within the Faculty of Medicine and Health Sciences (UAEU) for individuals or groups interested in medical education in order to promote scholarly activities in teaching and learning locally, regionally and internationally. Members of the Group PRIMARY AIMS include Chair Prof M McLean • Developing an ethos of medical education research within the FMHS Core members • Providing staff development to promote medical education Prof E Adeghate research through workshops, journal clubs, etc. Prof D Lloyd • Providing guidance and resources for those interested in Prof R Sadeghi medical education research Dr P Barss • Promoting and facilitating teaching and learning scholarship Dr M Grivna by publishing research in peer-reviewed journals, conference Dr C Howarth attendance, etc. Dr S Shaban • Co-ordinating medical education research activities within Ms G Kershaw the FMHS Dr Narchi • Promoting medical education research with the Gulf region and internationally by establishing networks of collaborators • Securing funding for medical research activities • Establishing focus areas in research in terms of the current and future trends in medical education • Communicating results of research activities to decision- and policy-makers • Involving students in the activities of MERGE, wherever appropriate

Research profile

1. Transferable/generic skills audit: Data collection is in its Medical Education

third year and involves a follow-up of Year 1 manuscripts are in the process of being students into year 2. The study assesses completed (McLean) students experience and confidence in 31 6.Student project 2: Meeting the identified skills. A year later, students are competencies of the CanMEDS roles in the FMHS asked to reflect on these skills (particularly curriculum. Where are they being met? What where they thought they lacked experience) activities contribute to their development? and indicate what activities contributed to MSC1 students began during the summer. A the development of these skills. Two complete poster was presented at the GCC conference years of data have been completed (McLean, in January 2009 (McLean) Shaban) 7. Community Medicine Health Promotion 2. Student perceptions of research: With Project: Evaluation. This project was projects now only voluntary, we are looking implemented a few years ago. The intention at why students choose to do research and any is to publish the outcomes of this project difficulties they may encounter (McLean, (Barss, Grivna). Kershaw)

3. Female and male medical students’ perceptions of the practice of medicine: Collaborative work with the University of KwaZulu-Natal. Final year students at the two institutions were interviewed in terms of being male and female students in their different cultures. The analysis began in November 2008. The follow-up of students as interns will begin in December 2009. A submission was been made to the UAEU Research Day (McLean)

4. Community Medicine curricula around the Gulf: Collaboratively with Dr Shaban and funded by a FMHS grant from Prof Aw. The survey has been piloted and distributed to the Deans of the various medical schools in the GCC. The aim is to collect data on what is included in the curriculum and how students learn different aspects of Community Medicine (e.g. projects in the community, tutorials, etc.) (Aw, McLean, Shaban)

5. Student project 1: Female Emirati patient choice of a physician and their experience with medical students. MSC 1 students undertook this project in the summer. 220 patients were interviewed. Data have been analysed and presented as a poster at the GCC Students’ Conference. A submission was made to the UAEU Research Day. An abstract will be submitted for the 2009 AMEE conference. Two

113 Neuroscience Research Group

Annual Report

Mission The mission of the Group shall be to: • Support and promote neuroscience in Al Ain and the UAE • Give encouragement and assistance to, and strengthen ties between, its members • Organize seminars, congresses and workshops in the field of neuroscience • Collaborate with and participate in scientific activities of other groups in the field of neuroscience nationally and internationally. • Develop educational programs at the UAE University that lead to higher degrees in Neuroscience

Major Achievements In the year 2008 the members of the group have presented several abstracts in national and international meetings and a number of publications have resulted from their research activities. Several members of the group have received major research grants from local and international bodies including Michael J. Fox Foundation for Parkinson’s Research, USA, Shaikh Hamdan Award for Medical Sciences, Terry Fox Grant, Emirates Foundation, and several FMHS & UAE University Research Grants.

Several members of the group hold membership in prestigious organizations and serve on the editorial board of international journals and committees. Also the group members collaborate with a number of research groups, institutions and organizations within the UAE & abroad.

UAE: Al Ain Hospital, Al Ain Central Veterinary Research Laboratory, Dubai Centre for Arab Genomic Study Neuroscience

Faculty of Science, UAEU University of Aarhus, Denmark El-Agnaf O (Biochemistry). Tawam Hospital, Al Ain Universita La Sapienza, Rome Galadari S (Biochemistry). Zayed University, Dubai University of Aalborg, Denmark Nicholls MG (Internal University of Amsterdam, Medicine). Abroad: Netherlands Lukic M (Medical Boston College, MA, USA University of Bonn, Germany Microbiology). Bogomeletz Institute, Ukraine University of California and San Al-Gazali L (Paediatrics). Conway Institute, Dublin, Diego, USA Gururaj A (Paediatrics). Ireland University of Gevle, Sweden Petroianu G (Pharmacology). Columbia University, NY, USA University of Glasgow Adem A (Pharmacology). Chapman University, USA University of Groningen, Hasan MY(Pharmacology). Chinese University of Hong Netherlands Bastaki S (Pharmacology). Kong, China University of Turin, Italy Attoub S (Pharmacology). Center of Molecular University of Xi'an, China Murat Oz (Pharmacology). Neurobiology, University of Utrecht Medical Centre, Fahim M (Physiology). Hamburg, Germany Netherlands Lammers W (Physiology). Harvard Medical School, USA Ljubisavljevic M (Physiology). Imperial College, London Summary of Grants & El-Rufaie O (Psychiatry). Institut Pasteur de Lille, Cedex, Publications 2008 (refer to Raguram R (Psychiatry). France departmental reports as Osman O (Psychiatry). Institutes for Medical Research below): Moselhy H (Psychiatry). and Neurology, Belgrade, Shehab S (Anatomy). Salem M (Psychiatry). Yugoslavia Adeghate E (Anatomy). Amri L (Psychiatry). Iowa Medical School, USA Mensah-Brown E (Anatomy). Corr P (Radiology). James Cook University, Dietrich Lorke (Anatomy). Gorkom van K (Radiology). Queensland, Australia Conlon JM (Biochemistry). Janssen Research Foundation, Belgium Lancaster University, UK Kyoto Prefectural University of Medicine, Kyoto, Japan Laboratory of Neurogenetics, National Institute on Aging, Maryland, USA Mayo Clinic, Florida, USA Manchester University, UK McMaster University, Canada National Institute of Health, USA Royal Free & University College London Medical School, UK SGHMS, University of London, UK Sultan Qaboos University, Confocal image of a section of the fifth lumbar dorsal root ganglion Muscat, Oman showing isolectin B4 (IB4) labelled neurons (green) and cholera toxin The Karolinska Institute, subunit B (CTb) labelled neurons (red) from a rat which had IB4 and CTb injection into the sciatic nerve. IB4 and CTb were used as Sweden neuroanatomical tracers to label umyelianted neurons which are The Queen’s University of involved in pain sensation and myelinated neurons which are Belfast, UK involved in touch sensation respectively. University of Manchester, UK (Courtesy of Dr Safa Shehab)

115 Oncology Research Group

Annual Report

Introduction

The Oncology Research Group (ORG) comprises colleagues at FMHS and the Abu Dhabi Health Authority, who share an interest in oncology research. The Chair of this group is Prof. Thomas Adrian and the Vice-Chair is Prof. Frank Branicki. Dr. Jorgen Kristensen at Tawam Hospital is the Deputy Chair.

Objectives

• To promote cancer research – being a catalyst for research activity • To create a forum for collaboration between Faculty members, basic scientists and colleagues in clinical disciplines, Faculty staff and colleagues of the Abu Dhabi Health Authority dealing with oncology. • To create and maintain an inventory of - research activities - resources available - basic research expertise - available clinical services - specialty interests – subspecialties - individuals – registry of interest in Oncology • To act as a reference group regarding cancer research and funding • To act as an Advisory body to the Abu Dhabi Health Authority regarding cancer issues of national interest, e.g. breast cancer screening, cervical screening, risk factors • To create a unified list of all cancer-related educational activities countrywide • To act as an Advisory body for education regarding cancer, organizing lectures on cancer, cancer conferences and meetings at a local and national level Oncology

•To promote quality control in the of the ORG members were included in the management of patients with cancer recently-funded, National Research Foundation, Genes and Diseases Research Cancer Database Center of Excellence Award. Members of the group are supporting efforts to improve the national cancer register at CANCER-RELATED PUBLICATIONS AND Tawam hospital. This is considered to be the PRESENTATIONSOF ORG MEMBERS IN 2008 cornerstone of cancer surveillance in the UAE This year members of the ORG published 30 and will provide the tool to measure the publications in peer-reviewed journals nation’s progress against cancer. A committee including the Lancet, Cancer Research, Clinical has been set up under the leadership of Dr. Cancer Research, Proceedings of the National Jorgen Kristensen to work on all aspects of the Academy of Sciences, Journal of the American registry. In the future all government and Medical Association, British Journal of Cancer private healthcare providers in the UAE will and the Annals of the New York Academy of contribute to the registry. Sciences. The group also made 21 presentations at International meetings during the year. Tissue Bank The group considers this to be a valuable resource for oncology research in the UAE. The bank will provide for the collection, processing and storage of human tumors and appropriate control tissues for research. The bank will help to foster collaborations between clinical oncologists and basic scientists at the FMHS. Approval for the tissue bank from the human ethics committee is in place, although approval for individual projects utilizing tissue will have to be obtained by the project investigators. The equipment and staff for the tissue procurement bank are in place. A subcommittee has developed protocols for tissue collection and storage as well as other issues, such as ethical approval, consent, maintenance of records, authorship recognition for surgeons and pathologists participating in tissue collection, etc.

Cancer Research Day A cancer research day is being planned for the autumn of 2009.

CANCER-RELATED GRANT AWARDS OF ORG MEMBERS IN 2008 During 2008, members of the ORG received a total of 17 research grants for their work, including six awards from the Terry Fox Fund for Cancer Research, two UAE University Interdisciplinary Awards, one from the Sheikh Hamdan Awards. In addition, the projects of six

117 Trauma Research Group

Annual Report

Summary During 2008 the Trauma Group has made major contributions in trauma education and research both nationally and internationally. The“hands on training”in point of care ultrasound continued to flourish with introduction of a new course on Emergency Ultrasound.The group has run four courses in 2008, now published 14 papers related to trauma in international refereed journals, and presented more than twenty five abstracts with oral presentations at national and international meetings. The results of a major interdisciplinary grant “road traffic collision injuries”were analyzed and presented internationally and were highly appreciated. This includes full details of 1007 motor vehicle collisions collected over one and a half years .

Mission Our mission is to promote and perform research and education of a high standard in the field of trauma so as to improve patient care.

MAJOR ACHIEVEMENTS OF THE TRAUMA GROUP IN 2008 INCLUDE:

A) Road Traffic Collision Registry This project has run as planned and was successfully completed. We have collected detailed information on 1007 patients involved in road traffic collisions and pre-event information over one and a half years and data were analyzed. These data were presented at national and international meetings. A web-based road traffic collision registry has been established (Fig 1).

B) Participation in Scientific Courses The Trauma Group was actively involved in the organization and conduct of numerous courses.

118 Trauma

1) AdvancedTrauma Life Support (ATLS) Provider Sciences, UAE University. and Instructor Courses: It was deemed essential 2. Critical Care Department, Tawam Hospital in to train UAE doctors using ATLS principles to affiliation with Johns Hopkins Medicine. improve the management of trauma patients. 3. Al-Ain Hospital managed by University of More than 889 doctors have taken the Provider Vienna/Va Med. Course to date in UAE. We have been 4. Health Authority Abu Dhabi (HAAD). encouraged by the increasing support and 5. Sheikh Hamdan Award for Medical Sciences. popularity of ATLS in the UAE. This course has been conducted at the Faculty of Medicine and Health Sciences four times every year. A greater awareness of the value of ATLS enhancement of the early management of severe trauma is more evident in our setting.

2) Course on Focused Assessment Sonography (FAST) forTrauma.Twelve courses have been run since the establishment of this course. 216 doctors have received“hands on”training on the use of FAST.The majority were senior registrars from Emergency Medicine (Fig 2). We have noticed increasing support and popularity for FAST in clinical practice in our setting. We have increased the annual number of point of care ultrasound courses from two to four. The demand from participants, local and overseas, is increasing. Sonosite has loaned four advanced Sonosite hand-held ultrasound machines to Fig 1. Establishing a Road Traffic Collision Registry of Al-Ain City was one of the major help us run our courses. These activities led to achievements of the Trauma Group. the establishment ofThe Clinical SkillsTraining Centre at the Faculty of Medicine and Health Sciences, UAE University (www.fmhs.uaeu.ac.ae/cstc) C) Preparation of an International Conference on Trauma Management, The scientific program was built on controversial Critical Care and Prevention themes. Parallel sessions will cover four main The Trauma Group is actively involved in areas: Disaster Medicine,Trauma Management, planning an international Conference entitled Critical Care and Injury Prevention. Four ‘Trauma Management, Critical Care and workshops are to be held on 16 February 2009. Prevention. The above conference will take These will include ‘hands on training’ in four place at the Intercontinental Hotel and Resort areas: Focused Assesment Sonography of at Al-Ain on 17-19 February 2009. The Trauma, Critical Care Ultrasound, Percutaneous Conference is an initiative of theTrauma Group Tracheostomy and Establishing a Trauma at the Faculty of Medicine and Health Sciences Registry. (FMHS), United Arab Emirates University and planning for the conference began on 4 The main conference will be three full days. February 2007. Sixteen well known international experts from North America, Europe, Canada, South Africa, Five organizations are involved in the Australia and the GCC countries have accepted preparation of this conference: the participation in the conference. 1.Trauma Group, Faculty of Medicine and Health This International Conference will provide a

119 Trauma

Fig 2. Specialty and rank of trained participants of the FAST Courses

forum for the exchange of ideas and knowledge organs. A website of the conference has been concerning trauma management.The meeting designed (http://www.traumaconf.uaeu.ac.ae). will focus on recent advances and controversies through interaction with renowned D) Successful Grants international speakers. The conference will be Grants of a multidisciplinary nature as Surgeons, • Road Traffic Collision Injury Registry in Al-Ain Emergency Physicians, Critical Care Physicians, City, Interdisciplinary University Research Radiologists, Epidemiologists, prehospital staff Grant. as well as hospital based medical and nursing • The magnitude and risk factors of childhood staff in the United Arab Emirates and those from injuries in UAE. Funded by Johnson & Johnson other GCC are expected to participate. The Middle East and Safe Kids Worldwide program has been structured in the form of • Educational Grant to support Point of Care plenary and parallel lectures and symposia, as Ultrasound courses, Sonosite, Middle East. well as oral and poster presentations. Issues Details of these grants are to be found in the addressed will include evidence based diagnosis relevant Departmental Reports (Department and management of trauma patients, damage of Surgery and Department of Community control surgery and angioembolization, Medicine). abdominal compartment syndrome, and new trends in trauma research including E) Publications and Abstracts management of coagulopathy and sepsis. In 2008, the group has published 14 papers Specific important topic sessions such as related to trauma in international referred prehospital care, trauma education and training, journals and one research monograph. Both trauma registries and systems, disaster quality and quantity of research has improved. management, injury prevention, biomechanics These papers stemmed from collaborative work and road safety will also featured as well as with Tawam and Al-Ain Hospitals networking dealing with trauma management of specific between the University and these two

120 Trauma

institutions. The group has presented more than twenty five abstracts and oral presentations at national and international meetings in 2008. Details of these publications and presentations are also to be found in the relevant Departmental Reports (Department of Surgery, and Department of Community Medicine).

E) Clinical Service Role: Professor Branicki (member) and Professor Abu- Zidan (Co-Chair) continue to serve on the Trauma Committee of Tawam Hospital. The members of the Trauma Group are actively participating in the Trauma CME program of Tawam Hospital. Furthermore, The Trauma Group has established a hospital-based trauma registry in Tawam Hospital. Dr Hani Eid has moved to Tawam Hospital to work in the Emergency Department as well as establishing this registry.TheTrauma Group has also helped Al-Rahba Hospital (Abu Dhabi) and Rashid Hospital (Dubai) to start their Registries. Our ultimate goal is the establishment of a nationwide registry.

121

Medical Students Research 124 Medical Student Research

2008 has been a very busy year for student research. A major activity has been the preparations leading up to“The 6th International Scientific Conference for Medical Students in the GCC Countries”.The summer was also a busy time for research. “The 6th International Scientific Conference for Medical Students in the GCC Countries”

Nearly 200 students have been involved in the organisation of the conference which was held in the Faculty of Medicine & Health Sciences (FMHS), United Arab Emirates University (UAEU), January 18-21st, 2009. More than 1600 delegates from more than 35 countries were registered to attend the event which included 6 international keynote speakers, 74 oral and 198 posters, 17 workshops, 2 plenary sessions, a Medical Exhibition and a variety of social events.

The keynote speakers included: Professor Sir Bruce Ponder, Director of Cancer Research UK Cambridge Research Institute, UK; Professor David C. Dale, Professor of Medicine, University of Washington, USA; Doctor Joyce Pickering, Associate Dean, Medical Education & Student Affairs, Faculty of Medicine, McGill University, Canada; Professor Adekunle Dawodu, Professor of Paediatrics, Director of International Patient Care and Education, Cincinnati Children’s Hospital Medical Centre, USA; Professor Ronald Harden, Director, Centre for Medical Education, University of Dundee, Scotland; Professor Ronald Berk, Professor of Biostatistics & Measurement, Former Assistant Dean forTeaching, The Johns Hopkins University, USA. Medical Students Research

FMHS students contributed 14/74 Oral and 18/198 Poster presentations and two of our presentations won awards:

“The cellular mechanisms of Missense mutation in ALK1 causing hereditary HemorrhagicTelangiectasiaType 2”, Al-Awadhi A, Al- Suwaidi S, John A, Karuvantevida N, Allistair N & Ali B. Supervisor: Doctor Bassam Ali, Department of Pathology. Basic Science, Oral Award.

“Mutational analysis of the predicted secondary RNA structure of Feline immunodeficiency virus (FIV) packaging signal”, Al Shamsi N, Al Neyadi A. Supervisor: Professor Tahir Rizvi, Department of Medical Microbiology. Doctor Rafia Ghubash, Oral Award.

Abstracts from the conference were published in a special edition of the “Journal of Medical Sciences”, the official publication of Sheikh Hamdan Bin Rashid Al Maktoum Award for Medical Sciences.

The event was supported by a variety of generous sponsors including: Health Authority – Abu Dhabi, Sheikh Hamdan Award for Medical Sciences, Sheikh Khalifa Medical City, Abu Dhabi Company for Onshore Oil Operations, Al Ain Hospital Medical University of Vienna, Tawam Hospital in affiliation with John Hopkins Medicine, The British Council, Lagap SA, Lari, FMHS, UAEU and others. ETIHAD Airlines were the official carriers for the conference.

Summer Research

Around 50 students took part in research activities during the summer and many of the projects were carried out in FMHS Research Laboratories. Four students were selected to join the UK Research Scholarship Program.This initiative is supported by the British Council and FMHS and provides opportunities for selected students to participate in research activities in‘cutting- edge’research laboratories in the UK during the summer holidays. Fatima Rashid Ali Al Kindi visited the laboratory of Professor Catherine Sarraf, Department of Biomedical Sciences, University of Westminster, London; Hind Saif Sultan Al Dhaheri visited the 126 Medical Students Research

laboratory of Professor Saadeh Suleiman, Bristol Heart Institute, University of Bristol, Bristol; Mariam Saleh Ali Al Harbi visited the laboratory of Professor Peter Ellaway, Division of Neurosciences & Mental Health, Faculty of Medicine, Imperial College London; Sarah Khamis Mohd Alsuwaidi visited the laboratory of Professor Miguel C. Seabra, Molecular & Cellular medicine, National Heart & Lung Institute, Faculty of Medicine, Imperial College London.

Some of our students contributed presentations at the “Chancellors Undergraduate Research Awards”(CURA) and“The 9th Annual UAE University Research Conference”.

Harvard Medical School Dubai Centre Tamayoz Award

In recognition of his research activities Ahmed Al Hammadi, now a senior Medical Student, received the Harvard Medical School Dubai Center Tamayoz Award in the category Trainee Award for Research (2008). Ahmed spent three years working in the field of diabetes and heart function in the laboratory of Professor Chris Howarth. In 2007 Ahmed was selected for a UK Research Scholarship and spent the summer holidays working in the laboratory of Professor Saadeh Suleiman at the Bristol Heart Institute, University of Bristol. He contributed to the publication of a full paper in the Journal of Molecular & Cellular Biochemistry (2007) and has presented his research at various national and international conferences.

127 Medical Students Research

Examples of Recent Publications

Omar Al-Falasi, Khalid Al- Ganczak M, Barss P, Alfaresi F, Dahmani, Khalid Al-Eisaei, Almazrouei S, Muraddad A & Salem Al-Ameri, Fatma Al- Al-Maskari F (2007) Break the Maskari, Nicholas Nagelkerke silence: HIV/AIDS knowledge, and John Schneider (2008) attitudes, and educational Knowledge, Attitude and needs among Arab university Practice of Anabolic Steroids students in United Arab Use Among Gym Users in Al- Emirates. J Adolesc Health, Ain District, United Arab 40: 572.e1-8. Emirates, The Open Sports Medicine Journal, 2, 75-81. Ganczak M, Barss P, Al- Marashda A, Al-Marzouqi A & Barss P, Subait OM, Al Ali MH Al-Kuwaiti N (2007) Use of & Grivna M (2008) Drowning the haddon matrix as a tool in a high-income developing for assessing risk factors for country: newspapers as an sharps injury in emergency essential resource for injury departments in the United surveillance. J Sci Med Sport, Arab Emirates. Infect Control doi:10.1016/j.jsams.2007.08.0 Hosp Epidemiol, 28: 751-4. 16. Howarth FC, Al-Sharhan R, Howarth FC, Al Ali S, Al Al-Hammadi A & Qureshi MA Sheryani S, Al Dhaheri H, Al (2007) Effects of Junaibi A, Almugaddum FA, streptozotocin-induced Qureshi MA & Ljubisavijevic diabetes on action potentials M (2007) Effects of voluntary in the sinoatrial node exercise on heart function in compared with other regions the streptozotocin-induced of the rat heart, Molecular & diabetic rat, International Cellular Biochemistry, 300: Journal of Diabetes & 39-46. Metabolism, 15: 32-37. Kosanovic M, Hasan MY, Conlon JM, Al-Dhaheri A, Al- Subramanian D, Al Ahbabi Mutawa E, Al-Kharrge R, AA, Al Kathiri OA, Aleassa EM Ahmed E, Kolodziejek J, & Adem A (2007) Influence of Nowotny N, Nielsen PF & urbanization of the western Davidson C (2007) peptide coast of the United Arab defenses of the Cascades Emirates on trace metal frog, Rana cascadae: content in muscle and liver implications for the of wild Red-spot emperor evolutionary history of frogs (Lethrinus lentjan). Food of the Amerana species Chem Toxicol, 45: 2261-2266. group, Peptides, 28: 1268- 1274.

128 National Medical Library and Impact Factors National Medical Library

Research Profile

Director The National Medical Library (NML) together with TBA the Faculty of Medicine and Health Science Sr. Ref Librarian Mr. A.V. Thomas continued to provide wide and efficient access to Circulation Librarian information to all Health Science Professionals in Mr. Osama Kayal the country. Ms. Muna Abdul Hameed Catalogue Librarian Mr. Khurshid Iqbal The NML houses a print collection of medical books and journals Acquisition Librarian along with a growing collection of e-resources and medical Mr. Khalid Pasha databases accessible via NML website. In addition, the NML Reference Librarian hosts a growing number of learning resources for the educational Ms. Hessa Ahmed needs of the faculty such as DVD’s, models and charts. Library Library Technical Assistant services may be obtained through physically visiting the library Mr. Koya Kariankandy or by requesting them online. A staff of professional and para- Mr. Abdul Salim professionals are available to assist all library users. Mr Abdurahiman In recent years, the NML has also housed the simulcast digital Ms Eben Prasad classrooms and the student computer laboratories, both developments that have ensured a much more prominent and lively attendance of students than is usual in a traditional library. In fact, as with other libraries in the world, the NML is witnessing a rapid change towards multi media contents than ever before, providing information services at a distance, typically at the desktop of individual faculty or closer by as with the growing collections of learning materials such as CD’s, DVD’s, anatomical and pathophysiological models. Finally it is hoped that with the arrival of the new librarian, this development may continue thereby ensuring that the NML will enter the digital age as befits the largest medical repository of the nation.

130 National Medical Library

Standing Left to right: Mr. Abdurahiman, Mr. Khurshid Iqbal, Mr. Ahmed Fathy (LRC), Mr. Abdul Salim, Mr. Khalid Pasha Sitting Left to right: Mr. Osama Kayal, Ms. Widad Al Jaili (LRC), Ms. Muna Abdul Hameed, Ms. Eben Prasad, Mr. A.V.Thomas Abcent: Ms. Hessa Ahmed 2008National Medical Library

http://www.fmhs.uaeu.ac.ae/nml/ Tel: 00971 3 7672000 Fax: 00971 3 7678755

131 Impact Factor

Journal Impact Factor Journal Impact Factor

Lancet 28.638 Int J Med Microbiol 2.524 Science 26.372 Malar J 2.473 Pediatr Allergy Immunol 2.454 Gastroenterology 11.673 Diagn Microbiol Infect. Dis 2.448 Am J Hum Genet 11.092 Am J Med Genetic Part A 2.440 Nano Letters 9.627 Regul Peptides 2.422 J Allergy Clin Immunol 8.115 J Adolescent Health 2.387 J Neurosci 7.490 Eur J Pharmacol 2.376 J Immunol 6.068 Peptides 2.368 J Infect Dis 6.035 Comparative Biochem & Physiol C 2.345 AIDS 5.842 J Trauma 2.334 RNA 5.840 Int J Infection 2.250 Emerg Infect Dis 5.775 Toxicon 2.246 Env Health Perspect 5.636 Surg Endosc 2.242 J Virol 5.332 Brain Res 2.218 Am J Epidemiol 5.285 Food & Chem Toxicol 2.186 Cell Mol Life Sci 5.239 Stat Appl Genet Mol Biol 2.167 Pediatr Blood and Cancer 2.164 Current Med Chem 4.944 Nutrition 2.104 Am J Med 4.907 J Med Microbiol 2.091 Free Radical Biol & Med 4.813 Mol Medicine 2.078 Int J Immunopathol Pharmacol 4.665 Chem Biol & Drug Design 2.043 Cochrane Database Sys Rev 4.654 Exp Brain Res 2.027 J Neurochem 4.451 Neurobiol Dis 4.377 Parkinsonism Relat. Disordr 2.021 Biochem Journal 4.009 Perit Dial Int 1.995 Exp Neurology 3.982 Exp Biol Med (Maywood) 1.979 Toxicology & Applied Pharmacol 3.846 J Appl Toxicol 1.942 Acta Psychiatrica Scandinavica 3.782 J Epidemiol 1.906 AIDS Reviews 3.714 Diabetes Res. Clin. Pract 1.823 Am J Physiol Reg 1 3.661 Patient Educ Coums 1.792 J Neurosci Research 3.268 Scan J Gastroenterol 1.758 Clin Genet 3.181 Ann NY Acad Sci 1.731 Acta Neuropathologica 3.179 Am J Health Sys Pharm 1.708 Cell Proliferation 3.120 Mol Cell Biochem 1.707 Pediatr Infect Dis J 3.086 Clin Toxicol 1.706 Mini Rev Med Chem 3.060 J Inherit Metab Dis 1.668 Exp Physiol 3.014 BMC Public Health 1.633 Neurotoxicology 3.009 Leuk Lymphoma 1.512 Anal Biochem 3.002 Injury 1.509 Clin Microbiol Infect 2.980 J Nutrition Health Ageing 1.475 J Physical Chemistry A 2.918 Appl Immunochem & Mol Morphology 1.474 Biochemie 2.899 Acta Paediatr 1.411 Mol Human Reprod 2.871 Anal Letters 1.362 Biological Chem 2.840 Neuropathology 1.326 Toxicol Lett 2.826 Archives of Gerontology & Geriatrics 1.289 Eur J Neurol 2.580 Nephrology 1.241 Evolution & Human Behav 2.529 Med Teacher 1.229

132 Journal Impact Factor Journal Impact Factor

Genet Test 1.218 J Emergency Med,Trauma & Acute Care - Gyn & Obs Investigation 1.157 J Headache Pain - Kidney Blood Press Res 1.092 J Islamic Med Assoc of N.A. - J Sci & Med in Sport 1.091 J Medical Sci - Ann Hum Biol 1.060 J Nephrology & RenalTransplantation - Br Dental J 1.018 JOccMed&Tox - J Environ Sci Health A Tox Hazard J Scholarship ofTeaching & Learning - Subst EnvironEng 0.967 Khartoum Pharmacy J - Med Biol Eng & Comp 0.943 MAM Paediatic Med - J Chemotherapy 0.922 Mol Cytogene - Wiener Klinische Wochenschrift 0.885 NZ Med J - Pharmazie 0.775 Open Medicinal Chem J - J Pediat Ophthalmol. Strabismus 0.765 Open Sports Med J - Ann Trop Paediatric 0.737 PLoS ONE - Archives of Gynecology and Obstetrics 0.666 Review of Diabetic Studies - Scot Med J 0.500 Scan J Surg - Int J Psychiatry in Clin Practice 0.446 Singapore Med J - Turk J Pediatr 0.408 South Afri Med J - Saudi Med J 0.329 Sri Lanka J of Child Health - J Cosmet Sci 0.283 Traffic Injury Prevention - Accident Analysis and Prevention - Afri Health Sci - Am J Ment. Retard - Arab J Psychiatry - Biochemica Biophysica Acta - Biomed Eng. Online - BMC Nephrol - BMJ Monograph - Cardio J South Africa - Chronic Illin - Congenit Anom - CurrentTopics in Naturaceutical Res - CurrentTrends in Biotech & Pharmacy - Cutan Pathol - Eastern Medit Health J - Emirates Med J - Eur J Echocardiogr - Health Care for Women Intl - Health Info Library J - Hematol Oncol Stem Cell Ther - Int Psychiatry - Int J Surgery - Int Urogynecol J Pevic Flr Dysfunction - Iran J Radiol - J Ambul Care Manage - J Canadian Family Physicians - J Cardiology -

133

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