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Annual Report 1983 Cold Spring Harbor Laboratory Box 100 Cold Spring Harbor, New York 11724 Editors, Elizabeth Ritcey, Dorothy Brown Photographers, Joan James, Rosemary Chan Photo editor, David Mick los Cover photo: Urey Cottage, renovated in 1983 under the supervision of Jack Richards and the Laboratory's Buildings and Grounds staff, provides offices for the Publications Department. (Photo by Herb Parsons) Photo page ii: Situated at the entrance to the Labora- tory, Davenport House is one of seven structures on the grounds dating from the 19th century. Annual Report 1983 LUMMINI 11111M1111 111111MIN, atalla COLD SPRING HARBOR LABORATORY Annual Report 1983 GOVERNANCE AND MAJOR AFFILIATIONS The Laboratory is governed by a 25-member Board of Trustees which meets three or four times a year. Authority to act for the Board of Trustees between meetings is vested in the Executive Committee of the Board of Trustees. The Executive Committee is composed of the Officers of the Board plus any other members who may be elected to the Executive Committee by the Board of Trustees. Additional standing and ad hoc committees are appointed by the Board of Trustees to provide guidance and advice in specific areas of the Laboratory's operations. Representation on the Board of Trustees itself is divided between community representatives and sci- entists from major research institutions. Ten such institutions are presently represented on the Board of Trustees: Albert Einstein College of Medicine, Columbia University, Duke University, Massachusetts Institute of Technology, Memorial Sloan-Kettering Cancer Center, New York University, The Rockefel- ler University, The State University of New York at Stony Brook, University of Wisconsin, and Yale University. Institutional Trustees were brought onto the Board during the 1960s-a difficult period when the Laboratory was undergoing reorganization as an independent entity. In addition to supplying scien- tific leadership to the governing body, participating institutions also provided emergency funds to help keep the Laboratory afloat during this crucial phase of development. Although participating institu- tions now give only token financial support, their Trustees continue to help steer the course of the Laboratory's scientific and administrative policies. Also represented as participating institutions are the Wawepex Society and the Long Island Biologi- cal Association (LIBA). The Wawepex Society was formed in the mid-nineteenth century as a philan- thropic arm of the Jones family, who supported the formation of the Laboratory. LIBA's origins began in 1890 when members of the local community became involved as friends and with membership on the Board of Managers of the Biological Station in Cold Spring Harbor, under the aegis of the Brooklyn Academy of Arts and Sciences. When the Brooklyn Academy withdrew its support of the Biological Station, community leaders, in 1924, organized their own association that actually administered the Laboratory until the Laboratory's reorganization as an independent unit in 1962. Today, LIBA remains a nonprofit organization organized under the Department of Social Welfare of the State of New York and represents a growing constituency of 'friends of the Laboratory." Its 450 members support the Laboratory through annual contributions and participation in fund drives to raise money for major construction projects. The Laboratory is chartered as an educational and research institution by the Board of Regents of the Education Department of the State of New York. It is designated as a 'public charity" by the Inter- nal Revenue Service and claims special status as a school under the Internal Revenue Code. OFFICERS OF THE CORPORATION Walter H. Page, Chairperson Dr. Bayard Clarkson, Vice-Chairperson Dr. Norton D. Zinder, Secretary Robert L. Cummings, Treasurer Roderick H. Cushman, Assistant Treasurer Dr. James D. Watson, Director William R. Udry, Administrative Director BOARD OF TRUSTEES Institutional Trustees Individual Trustees Albert Einstein College of Medicine Robert L. Cummings Dr. Matthew Scharff Roderick H. Cushman Duke University Oliver R. Grace Dr. Robert Webster Mary Jeanne Harris Long Island Biological Association Ambassador John P. Humes Edward Pulling John Klingenstein Massachusetts Institute of Technology Dr. Ralph Landau Dr. Boris Magasanik Mary Lindsay Memorial Sloan-Kettering Cancer Center Walter H. Page Dr. Bayard Clarkson William S. Robertson Columbia University Alexander C. Tomlinson Dr. Eric R. Kandel Dr. James D. Watson New York University Medical Center Taggart Whipple Dr. Claudio Basilico State University of New York, Stony Brook Dr. Thomas E. Shenk The Rockefeller University Dr. Norton D. Zinder University of Wisconsin Dr. Masayasu Nomura Wawepex Society Honorary Trustees Townsend J. Knight Dr. Harry Eagle Yale University Dr. H. Bentley Glass Dr. Charles F Stevens Dr. Alexander Hollaender COMMITTEES* Audit Finance Plant Molecular Biology Alexander C. Tomlinson, Chairman Robert L. Cummings, Chairman Dr. Norton D. Zinder, Chairman Ambassador John P. Humes Roderick H. Cushman Dr. Ralph Landau Townsend J. Knight Oliver R. Grace Dr. Thomas E. Shenk Ambassador John P. Humes Dr. James Hicks Banbury Program Townsend J. Knight Dr. Russell Malmberg William S. Robertson Dr. Norton D. Zinder, Chairman Alexander C. Tomlinson Dr. Bayard Clarkson Tenure & Appointment William R. Udry Robert L. Cummings Taggart Whipple Dr. Norton D. Zinder, Chairman Mary Lindsay Dr. Claudio Basilico Walter H. Page Dr. Boris Magasanik Dr. Matthew Scharff Building Infrastructure & Future Plans Edward Pulling, Chairman Robertson House Roderick H. Cushman Dr. Bayard Clarkson, Chairman William S. Robertson, Chairman Oliver R. Grace Mary Lindsay Mary Jeanne Harris Mary Jeanne Harris Robert L. Cummings John Maroney Mary Lindsay Roderick H. Cushman Anne Meier Elizabeth Watson Ambassador John P. Humes Dr. Ralph Landau Jack Richards Dr. Michael Shodell Commercial Relations John Maroney Jack Richards Townsend J. Knight, Chairman William R. Udry Robertson Investment Dr. Ralph Landau Dr. James D. Watson Dr. Richard Roberts Robert L. Cummings, Chairman Dr. Matthew Scharff Oliver R. Grace William S. Robertson Dr. Jeffrey Strathern Neurobiology Taggart Whipple William R. Udry Dr. Charles F. Stevens, Chairman Taggart Whipple Executive (Elected) Dr. Matthew Scharff Dr. James D. Watson Dr. Ronald McKay Walter H. Page, Chairman Dr. Joseph Sambrook Dr. Bayard Clarkson Robertson Research Fund Robert L. Cummings (Laboratory Representatives) Roderick H. Cushman Nominating Robert L. Cummings, Chairman Dr. Charles F. Stevens Walter H. Page William R. Udry Edward Pulling, Chairman Alexander C. Tomlinson Dr. James D. Watson Mary Lindsay William R. Udry Dr. Norton D. Zinder Dr. Matthew Scharff Dr. James D. Watson *Committees and membership as of October 21, 1983. LABORATORY STAFF First row: A. Klar, J. Strathern, J. Hicks; D. York, N. Cap lin Second row: D. Lukralle, C. Jackson; (top) F. Matsumura, J.J. Lin; (bottom) B. Stillman, T. Grodzicker, Y. Gluzman First row: J. Feramisco, W. Welch, D. Helfman, (foreground) G. Binns, J.L. Lin; 0. Fasano, S. Powers, E. Taparowski, T. Kataoka, C. Birchmeier, M. Wig ler, (foreground) L. Edlund, D. Birnbaum Second row: J.-Z. Li, W. Addison, E. Nozik, D. Danna, D. Matkovich; R. Gerard, M. DeLuca Third row: R. McKay, K. Frederiksen, A. Hishinuma, S. Hockfield, E. Waldvogel; (top) J. Garrels, S. Blose; (bottom) J. Wood James D. Watson, Director Joseph Sambrook, Assistant Director for Research William R. Udry, Administrative Director John Maroney, Assistant Administrative Director Michael Shodell, Banbury Center Director Research Staff Postdoctoral Yamada, Masao Research Fellows Yamashiro-Matsumura, Shigeko Beach, David Zerler, Bradley Blose, Stephen Adams, Timothy Bonitz, Susan Addison, William Broker, Thomas Bautch, Victoria Bukhari, Ahmadt Bhagwat, Ashok Chow, Louise Birchmeier, Carmen Visiting Scientists Daldal, Fevzi Birnbaum, Daniel Feramisco, James Dellaporta, Stephen Cai, Guang-Yun Garrels, James Flanagan, Thomas Fasano, Ottavio Gething, Mary-Jane Franza, Robert Frederiksen, Kristen Gluzman, Yakov Freyer, Gregory Hanahan, Douglas Goldfarb, Mitchell Gerard, Robert Hinton, Stephen Grodzicker, Terri Guilfoyle, Richard Kataoka, Tohru Harlow, Edward Helfman, David Li, Jin-Zhao Hicks, James Herr, Winship Lin, Pei Mao Hockfield, Susan Hiatt, Andrew Hughes, Stephen Huse, William Mar, Amar Ivy, John Kurtz, David Kamata, Tohru Support Staff Lewis, John Kataoka, Yuriko Lin, James Kiss, Antal Balamuth, Michael Lundell, Daniel Koka, Prasad Balke, Deborah Mathews, Michael Krangel, Michael Bird, Patricia Malmberg, Russell Livi, George Borruso, Robert Matsumura, Fumio Maclnnes, Janet Brings, Arthur McKay, Ronald Maihle, Nita Dalessandro, Louisa Roberts, Richard Mains, Paul Dellaporta, Joanne Rossini, Mara Martin, Kathy Donohue, Jeanne Ruley, Earl Maruyama, Kazuo Dulis, August Silver, Lee Moran, Elizabeth Goodwin, Marilyn Stillman, Bruce Patterson, Thomas Greene, David Strathern, Jeffrey Powers, Scott Jackson, Catherine Tamanoi, Fuyuhiko Roth, Michael Keller, Christopher Thomas, Paul Sadaie, Reza Lukralle, Deborah Topp, William Sundin, Olof Mickus, Raymond Welch, William Taparowski, Elizabeth Ockler, Michael Wigler, Michael Watts, Susan Renna, Philip Youvan, Douglas Weisbrod, Stuart Rubino, Marlene Zipser, Birgit Weiss, Robert Schubert, Richard Zoller, Mark White, Eileen Schwarz, Regina t We note with sorrow the death of Dr. Bukhari in November 1983. ix Suhan, Joseph Schley, Carol Dumser,
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