DOCSLIB.ORG

Journal of Pharmacy and Pharmacology 1954 Volume.6 No.10

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Journal of Pharmacy and Pharmacology 1954 Volume.6 No.10 v i „ •• ' u i • \ The Journal of PHARMACY and PHARMACOLOGY W. C. 1 H §>W] M icroscopical S t a i n s A complete range of Microscopical Stains of uniform high quality and~reliabilittMMBfeavailahlc from stock. RevectoR dye-rjj.Ts aj\ maiiuLdured m our own laboratorics_or‘afir■ carei■.! ¡#Mfeed^<>hr:the basis of appr&pfnSpSps for idcn^BBaiPpMt;^ v ' K ' AMJRE ETHYL EOSIN ¿lEM SA pTA i \ , •■■"IP-' LEISHHAI^ISlN fMEIHYLENE b l u e TOLUIDl M BLUE For the full range write for list H.l. HOPKIN & WILLIAMS LTD. Manufacturers <ff/ing.àtwRtieàlsfyr ßepaQrch and Analysis. t :: : ............ FRESH WATER ROACC,* CHADWELL HEATH, ESSEX. The Journal of PHARMACY and PHARMACOLOGY Successor to The Quarterly Journal of Pharmacy and Pharmacology 33 BEDFORD PLACE, LONDON, W.C.l Telephone: CHAncery 6387 Telegrams: Pharmakon, Westcent, London Editor: C. H. Hampshire, C.M.G., M.B., B.S., B.Sc., F.P.S., F.R.I.C. Associate Editor: G. Brownlee, D.Sc., Ph.D., F.P.S. Annual Subscription 50s. Single Copies 5s. Vol. VI. No. 10 October, 1954 CONTENTS page Review Article T he P resent Status of the C hemotherapeutic D rug s. By S. R. M. Bushby, M.Sc. (Brist.), Ph.D. (Lond.)...................... 673 Research Papers A n In Vivo M ethod for the A ssay of H epa r in . By J. Erik Jorpes, Margareta Blomback and Birger Blomback .. .. 694 A lkaloid B iogenesis. Part III. T he P roduction of B io­ synthetic R adioactive H yoscine a n d M eteloidine. By W. C. Evans and M. W. Partridge.. .. .. .. .. 702 [Continued on page ii A fine crop of peppermint plants on Ransom's drug-growing farm. Before you buy PEPPERMINT OIL make sure of the quality W here quality really counts, Ransom’s Oil of Pepperm int is preferred because of its excellence and constant reliability. Its quality never varies— its reputation is bom of years of specialization in the cultivation and distillation of the finest peppermint plants grown on Ransom’s own farm. Whenever manufacturing requirements call for peppermint oil, specify Ransom ’s, and be sure of the quality. Growers o f Medicinal plants for over a century. Established 1846 WILLIAM RANSOM & SON LTD. HITCHIN • HERTFORDSHIRE • ENGLAND 11 T he Journal of Pharmacy and Pharmacology O ctober, 1954 CONTENTS page* Research Papers—{continued) Piperazine A d ip a t e : a N ew A nthelmintic A gent. P art I. Physicochemical P roperties. By M. T. Davies, J. Forrest, F. Flartley and V. Petrow . .. .. .. 70^7 Piperazine A dipate: a N ew A nthelmintic A g ent. P art II. T oxicological a n d Pharmacological Studies. By B. G . Cross, A. David and D. K. Vallance .. .. .. .. 711 P reliminary T rials w ith P iperazine A dipate as a V eterinary A nthelmintic. By J. E. N. Sloan, P. A. Kingsbury and D. W. J o lly ....................................................................................................718 O n the M aintenance of Sterility in E ye-d ro ps. By M . Klein, E. G. Millwoodand W. W. Walther .......................................... 725 T he Estimation of B arbituric A cid D erivatives in B iological M aterial for M edico-legal P urposes. By Norman E. W. McCallum .. .. .. .. .. .. .. 733 A nticonvulsant A ctivity. D erivatives of Succinim ide, G lut- arimide, T hiazolidinedione, a n d M ethanol, a n d some M iscellaneous C om pounds. By P. G. Marshall and D . K. Vallance .. .. .. .. .. .. .. .. 740 Abstracts of Scientific Literature C hemistry .................................................................................................................747 B iochemistry .................................................................................................................751 C hemotherapy .. .. .. .. .. .. .. 753 P harmacy .................................................................................................................754 P harmacology a n d T herapeutics .........................................................756 B acteriology a n d C linical T ests .. .. .. .. 759 Book Review .. .. .. .. 760 EDITORIAL COMMITTEE C. W. M a p l e t h o r pe , f .p .s ., F.R.i.c. (Chairman), H. B e r r y , b .sc., Dip.Bact.(Lond.), F.P.S., F.R.I.C., G. R. BOYES, L.M.S.S.A., B.Sc., F.P.S., F.R.I.C., J. H. BURN, M.A., m.d ., f.r .s ., G. A. H. B u t t l e , o . b .e., m .a ., m .r .c .s ., l .r .c .p ., S ir H e n r y H. D a l e , o .m ., g .b .e., m .d ., f .r .c .p ., f .r .s ., H . D a v is, c .b .e ., b .sc., ph.D., f.p .s ., f.r .i.c ., J. H . G a DDUM, M.A., Sc.D., M.R.C.S., L.R.C.P., F.R.S., F. HARTLEY, B.SC., Ph.D., F.P.S., F.R.I.C., W. H. L iNNELL, D.Sc., Ph.D., F.P.S., F.R.I.C., SlR HUGH LiNSTEAD, O.B.E., f.p .s ., m .p ., A. D. M a c d o n a l d , m .d ., m .a ., m .sc., H . G . R o l fe , b .sc., f .p .s ., f .r .i .c ., T. E . W a l l is, d .sc., f .p .s ., f .r .i.c . S e c r e t a r y : F . W. A d a m s , b .sc., f .p .s ., a .r .i .c . A b s t r a c t o r s : A. H. B ec k e t t , b .sc., Ph.D., f.p .s ., f .r .i .c ., G. B r o w n , B.pharm., b .sc., f .p .s ., H. T reves B r o w n , b .sc., f.p .s ., H. D e a n e , b .sc., f .p .s ., f .r .i .c ., J. W, F a IRBAIRN, B.sc., Ph.D., F.P.S., J. R. FOWLER, B.Pharm., F.P.S., E. HAYES. B.Sc., M.P.S.I., A.R.I.C., G. R. KlTTERINGHAM, B.Se.. F.P.S., A.R.I.C., M . M ANN, B.pharm., Ph.D., G. MIDDLETON, B.Sc., F.R.I.C., G. PATERSON, B.Sc., M.Sc., G. R. A. S h o r t , f .p .s ., G . F . S om ers, b .sc., Ph.D., f .p .s ., J. B . S t e n l a k e , b .sc., Ph.D., f .p .s ., a .r .i .c ., R. E. S t u c k e y , b . sc., Ph D ., f .p .s ., f.r .i .c ., T. E. W a l l is, d .sc., f .p .s ., f.r.i .c., S. L. W a r d . Jetober , 1954 T he Journal of Pharmacy and Pharmacology M A L A R I A * * a boto tö p t w f l t m Increasing evidence from endemic regions indicates that ‘ Daraprim ’ can play a major part in eradicating malaria. This new drug has proved an excellent suppressant in a dosage of one product once a week ; when administered under supervision to an entire community it has been shown capable of breaking the malarial cycle. ‘ Daraprim ’ is tasteless and well tolerated ; it causes no discoloration of the skin. It is supplied as compressed products of 25 mgm., in packs of 6, 30, 250 and 1000. ‘DARAPRIM’B8AH0 PYRIMETHAMINE Issued in the French Union and in Tunisia and Morocco as ‘ Malocide ’ brand Pyrimethamine BURROUGHS WELLCOME & CO. (The Wellcome Foundation Ltd.) LONDON Associated Houses : New York • Montreal • Sydney • Cape Town • Bombay ■ Buenos Aires • Cairo • Dublin • Auckland The Journal of Pharmacy and Pharmacology O ctober, 1954 In the manufacture of drags and medicines, where purity is essential, rapid, precise and complete details of analysis are equally important to the research worker and the chemist in charge of production. The SP.600 Spectrophotometer allows methods developed in the laboratory to be applied in the factory with the same ease, accuracy and economy. The graph above illustrates the performance of the instrument which is equipped with a glass prism monochromator and two vacuum photocells, and may be operated from suitably stabilised mains or a 12V battery. UNICAM INSTRUMENTS LTD ARBURY WORKS CAM BRIDGE UI3OE REVIEW ARTICLE THE PRESENT STATUS OF THE CHEMOTHERAPEUTIC DRUGS By S. R. M. Bushby, M .S c. (Brist.), Ph.D. (Lond.) Wellcome Research Laboratories, Beckenham, Kent T he Sulphonamides T he sulphonamides may eventually be replaced by antibiotics with wider antibacterial activity but they continue to be very popular in general practice because of the ease with which they are administered, and their relative freedom from serious side effects. Hypersensitivity is probably their only common disadvantage especially when applied locally in skin infections. Although experimentally the sulphonamides are the least active of the chemotherapeutic agents they are sometimes more efficient clinically than the antibiotics. For instance, in a recent comparison1 between the sulphonamides and penicillin for the treatment of pneumonia, there was no difference amongst males in the incidence of pleural complications but in females for some unexplained reason the sulphonamides were superior to penicillin; and again in controlled trials2 in the treatment of infantile diarrhoea, sulphadiazine has proved to be superior to chlortetracycline or chloramphenicol. Also because succinylsulphathiazole and phthalyl- sulphathiazole provide good cover with little risk of serious side effects they have been regarded3 as more desirable than the wide-spectrum antibiotics for prophylactic therapy against bowel infection in abdominal surgery. The sulphonamides are also recommended for combined therapy, e.g., with streptomycin in H. influenza meningitis4 and in brucellosis5, or with neomycin as an intestinal antiseptic6. P enicillin Penicillin is often reputed to be the least toxic of all the antibacterial drugs and therefbre it may be surprising to read that “To-day penicillin heads the list of medicinal agents in the frequency, diversity and severity of the sensitivities which it induces.
Load more

Recommended publications
  • Peptide Chemistry up to Its Present State
    Appendix In this Appendix biographical sketches are compiled of many scientists who have made notable contributions to the development of peptide chemistry up to its present state. We have tried to consider names mainly connected with important events during the earlier periods of peptide history, but could not include all authors mentioned in the text of this book. This is particularly true for the more recent decades when the number of peptide chemists and biologists increased to such an extent that their enumeration would have gone beyond the scope of this Appendix. 250 Appendix Plate 8. Emil Abderhalden (1877-1950), Photo Plate 9. S. Akabori Leopoldina, Halle J Plate 10. Ernst Bayer Plate 11. Karel Blaha (1926-1988) Appendix 251 Plate 12. Max Brenner Plate 13. Hans Brockmann (1903-1988) Plate 14. Victor Bruckner (1900- 1980) Plate 15. Pehr V. Edman (1916- 1977) 252 Appendix Plate 16. Lyman C. Craig (1906-1974) Plate 17. Vittorio Erspamer Plate 18. Joseph S. Fruton, Biochemist and Historian Appendix 253 Plate 19. Rolf Geiger (1923-1988) Plate 20. Wolfgang Konig Plate 21. Dorothy Hodgkins Plate. 22. Franz Hofmeister (1850-1922), (Fischer, biograph. Lexikon) 254 Appendix Plate 23. The picture shows the late Professor 1.E. Jorpes (r.j and Professor V. Mutt during their favorite pastime in the archipelago on the Baltic near Stockholm Plate 24. Ephraim Katchalski (Katzir) Plate 25. Abraham Patchornik Appendix 255 Plate 26. P.G. Katsoyannis Plate 27. George W. Kenner (1922-1978) Plate 28. Edger Lederer (1908- 1988) Plate 29. Hennann Leuchs (1879-1945) 256 Appendix Plate 30. Choh Hao Li (1913-1987) Plate 31.
    [Show full text]
  • Polyuria) Mellitus – Sweet
    Hormones: the birth of a concept and how it gained recognition U3A Course, Spring Series 2017 Gil Barbezat What I plan to talk about: • First Session: History of hormones; concepts to chemicals Stories behind some key discovery milestones Technological help in advances • Second Session: How hormones work Hormones’ role in digestion Gut hormones in excess (tumours) What do you associate with the word ‘Hormone’ • Sex, Puberty, Menopause? • Body building, Athletes? • Maybe? Digestion Urine production Blood production and BP Brain function • Regulates our entire metabolism Early ‘application’ - Eunuchs • Intentional castration • Summerian city of Lagash in 21st C BCE Southern Mesopotamia (Iraq) • Applications: Guardians of rulers or women Singers Courtiers and domestics Why did this happen? Albrecht von Haller (1708 – 77) • Swiss poet, naturalist, theologian, anatomist, physiologist • “Father of experimental physiology” • Body ‘emanations’: Bile digests fat Body a reactive organism Salivary gland duct a blood vessel (MD) Theophile de Bordeu (1722 – 76) • French poet, philosopher, physician • Organs specific sensibilities • Each organ of the body produced a specific ‘emanation’ (humour) which it secreted into the bloodstream Claude Bernard (1813 – 78) Claude Bernard • Vaudeville comedy to medicine Med School in Paris 1834; physiology • Father of “Experimental medicine” Vivisection • ‘Milieu interieur’ Walter Bradford Cannon (1871 – 1945) • American physiologist at Harvard • Worked in lab of Henry Bowditch, a pupil of Bernard • Enlarged Bernard’s
    [Show full text]
  • Galanin Gaianin
    WENNER-GREN CENTER INTERNATIONAL SYMPOSIUM SERIES VOLUME 58 GALANIN GAIANIN A New Multifunctional Peptide in the Neuro-endocrine System Proceedings of an International Symposium at the Wenner-Gren Center, Stockholm, June 14-16, 1990 Edited by Tomas Hokfelt Department of Histology and Neurobiology Karolinska Institute Stockholm, Sweden Tamas Bartfai Department of Biochemistry, ArrheniusLaboratory University of Stockholm, Sweden David Jacobowitz Laboratory of Clinical Science NIMH, Bethesda, USA David Ottoson Wenner-Gren Center Foundation Stockholm, Sweden M MACMILLAN PRESS Scientific & Medical ©The Wenner-Gren Center 1991 Softcover reprint ofthe hardcover 1st edition 1991 978-0-333-56427-1 All rights reserved. No reproduction, copy or transmission of this publication may be made without permission. No paragraph of this publication may be reproduced, copied or transmitted save with written permission or in accordance with the provisions of the Copyright, Design and Patents Act 1988, or under the terms of any licence permitting limited copying issued by the Copyright Licensing Agency, 90 Tottenham Court Road, London WlP 9HE. Any person who does any unauthorized act in relation to this publication may be liable to criminal prosecution and civil claims for damages. First published 1991 by MACMILLAN ACADEMIC AND PROFESSIONAL LTD Houndmills, Basingstoke, Hampshire RG21 2XS and London Companies and representatives throughout the world ISBN 978-1-349-12666-8 ISBN 978-1-349-12664-4 (eBook) DOI 10.1007/978-1-349-12664-4 ISSN 0-0083-7989 A catalogue record of this book is available from the British Library. Contents Preface ix Participants X Vilctor Mutt by Bertil Aberg xvi Part I Discovery, Biochemistry and Molecular Biology 1.
    [Show full text]
  • January-February 2013 Volume 35 No
    CHEMISTRY International March-April 2006 Volume 28 No. 2 The News Magazine of IUPAC The News Magazine of the International Union of Pure and November-December 2012 Applied Chemistry (IUPAC) Volume 34 No. 6 InternationalCHEMISTRY InternationalThe News Magazine of IUPAC January-February 2009 Art and Science Volume 31 No. 1 Looking in the Same Direction ALCHEMISTS are US January-February 2013 Volume 35 No. 1 May-June 2007 March-April 2008 March-April 2011 Volume 29 No. 3 Volume 30 No. 2 Atomic Weights Volume 33 No. 2 No Longer Constants November 2012 covers.indd 1 10/29/2012 11:07:56 AM of Nature Roald Hoffmann’s Should’ve Ethics and Science on Stage Where Would We Be without Chemistry? Chemistry The Chemical Industry Assuring Quality of for Biology Scientifi ques Sans Frontières The International Year of and Sustainable Analytical Measurement Solubility Data Compilations Chemistry Begins! Development Results: The IUPAC Role May-June 2009 March-April 2005 January-Februa stry? Volume 31 No. 3 Volume 27 No. 2 Volume 33 March 2011 cover.indd iii 2/28/2011 3:32:55 PM e Responsible Care 10 YEARS IN in Canada Marie Skłodowska a special issue commemorating the 100 anniversary of her Nobel Prize in Chemis Beyond COLOR the Book Role Models in Pure and Applied Chemistry: Linus Pauling Chemistry: Citation Highlights 1998–2003 ii CHEMISTRY International September-October 2003 November-December 2003 September-October 2005 November-December 2006 Volume 25 No. 6 Volume 27 No. 5 Volume 28 No. 6 January 2011 cover.indd ii 1/3/2011 11:03:01 AM An Update on the Kilogram “It's A Chemical World!” GEOTRACES Chemistry Takes Center Stage in Marine Science The Overwhelming Success of A Poster Competition Crop Protection Chemistr in Latin America Would Einstein Nanotechnology: Lessons Challenges for Have Approved? from Mother Nature Chemists May-June 2011 Volume 33 No.
    [Show full text]
  • Richard K. Forster, MD: a Life Through the Lens of an Ophthalmologist
    The Newsletter of the Senior Ophthalmologist Spring 2020 | Volume 24 | Issue 2 SCOPE Richard K. Forster, MD: A Life Through which furthered his interest in bird anatomy. Although he did some the Lens of an Ophthalmologist hunting, trapping and fishing in his and Nature Photographer youth, he decided at the age of 11 to restrict his enjoyment of the out- By M. Bruce Shields, MD doors to observing his surround- ings and wildlife and participating s ophthalmologists, we in the woods and fields of his fam- in environmental conservation. have spent much of our ily’s 68 acres, enjoying the wildlife Acareers looking through that included a variety of birds: This early decision to admire and lenses in the office and the operat- chickadees, nuthatches, blue jays, preserve the wonders of nature, he ing room. And I suspect we have crows and occasional pheasants. In reflects, may have had something all shared the sense of awe as we 1949, he won a trip to the Eastern to do with his choice of medicine beheld the exquisite beauty and Poultry Judging contest in Boston, as a career. After graduating from intricacy of the human eye. Dartmouth College, he earned his medical degree at Boston University The thousands of examinations School of Medicine and, follow- that each of us have performed ing an internship at Boston City over the years have not only Hospital, joined the U.S. Public given us a respect for the Health Service and was fortu- elegance of nature, but itously assigned to Miami for has sharpened our two years.
    [Show full text]
  • Die Bekämpfung Der Thrombose Durch Anticoagulantia, Heparin Und Dikumarin
    Die Bekämpfung der Thrombose durch Anticoagulantia, Heparin und Dikumarin Autor(en): Jorpes, J. Erik Objekttyp: Article Zeitschrift: Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften = Bulletin de l'Académie Suisse des Sciences Medicales = Bollettino dell' Accademia Svizzera delle Scienze Mediche Band (Jahr): 3 (1947-1948) Heft 4-5 PDF erstellt am: 29.09.2021 Persistenter Link: http://doi.org/10.5169/seals-306903 Nutzungsbedingungen Die ETH-Bibliothek ist Anbieterin der digitalisierten Zeitschriften. Sie besitzt keine Urheberrechte an den Inhalten der Zeitschriften. Die Rechte liegen in der Regel bei den Herausgebern. Die auf der Plattform e-periodica veröffentlichten Dokumente stehen für nicht-kommerzielle Zwecke in Lehre und Forschung sowie für die private Nutzung frei zur Verfügung. Einzelne Dateien oder Ausdrucke aus diesem Angebot können zusammen mit diesen Nutzungsbedingungen und den korrekten Herkunftsbezeichnungen weitergegeben werden. Das Veröffentlichen von Bildern in Print- und Online-Publikationen ist nur mit vorheriger Genehmigung der Rechteinhaber erlaubt. Die systematische Speicherung von Teilen des elektronischen Angebots auf anderen Servern bedarf ebenfalls des schriftlichen Einverständnisses der Rechteinhaber. Haftungsausschluss Alle Angaben erfolgen ohne Gewähr für Vollständigkeit oder Richtigkeit. Es wird keine Haftung übernommen für Schäden durch die Verwendung von Informationen aus diesem Online-Angebot oder durch das Fehlen von Informationen. Dies gilt auch für Inhalte Dritter, die über dieses Angebot zugänglich sind. Ein Dienst der ETH-Bibliothek ETH Zürich, Rämistrasse 101, 8092 Zürich, Schweiz, www.library.ethz.ch http://www.e-periodica.ch D.K. 6I6.C0S.6; 617.089.168; 615.71 Aus der chemischen Abteilung des Karolinischen Instituts, Stockholm Die Bekämpfung der Thrombose durch afVnticoagulantia, Heparin und Dikumarin Von J.
    [Show full text]
  • Nobel Laureate Information From
    Dr. John Andraos, http://www.careerchem.com/NAMED/NobelAnecdotes2.pdf 1 Nobel Laureate Anecdotes Part 2 © Dr. John Andraos, 2003 - 2011 Department of Chemistry, York University 4700 Keele Street, Toronto, ONTARIO M3J 1P3, CANADA For suggestions, corrections, additional information, and comments please send e-mails to [email protected] http://www.chem.yorku.ca/NAMED/ Source : Hargittai, Istvan The Road to Stockholm: Nobel Prizes, Science, and Scientists , Oxford University Press: Oxford, 2002 Note: This compilation fills in some missing details not given in Hargittai's book. I have also amplified and clarified some ideas presented in the book where appropriate. Used with permission. Growth of Nobel Prize Money 2 VALUE OF NOBEL PRIZE (SEK) 1901 - 2000 9000000 8000000 7000000 6000000 5000000 4000000 3000000 2000000 1000000 0 1901 1910 1920 1930 1940 1950 1960 1970 1980 1990 1995 2000 YEAR How Do Nobel Laureates Spend Their Winnings? Albert Einstein (Physics, 1921) used his winnings as part of his divorce settlement from Mileva Maric in 1919. Michael Smith (Chemistry, 1999) donated his winnings to research on schizophrenia, science outreach programs, and the encouragement of women in science. Dorothy H. Crowfoot (Chemistry, 1964) donated her winnings to various charities. Günther Blobel (Medicine, 1999) used his winnings to help in the reconstruction of Dresden, Germany after its destruction in World War II. Philip W. Anderson (Physics, 1977) bought a new family home. Frederick Banting (Medicine, 1923) shared part of his prize money with his graduate student Charles Best and J.J.R. Macleod (Medicine, 1923) shared his part with the biochemist J.B. Collip who found a method of isolating insulin from the islets of Langerhans in pancreas tissue.
    [Show full text]
  • Lychnos 2019
    Mobilising skill and making skill mobile Crafoord’s surgical tours in South America, 1950–1965 !"#$%& #'()"(** Introductory letter On 23 February 1949, the 31-year-old Argentinian physician Rafael Alascio Escobar wrote a letter to the Swedish professor of thoracic surgery Clar- ence Crafoord (1899–1984). Alascio had graduated from Universidad Nacional de Córdoba, Argentina, in 1942, to begin his surgical training with Professor Juan Martín Allende (1895–1990), a respected thoracic surgeon in Córdoba,! followed by general surgery practice at a military hospital under the supervision of Dr Oscar Ivanissevich (1895–1976)." With Allende, Alascio specialised in thoracic surgery, which he further developed at Instituto de Tisiología and the British Hospital in Buenos Aires, and the San Juan Hospital in the city of La Plata.# Alascio was therefore an active surgeon when he wrote to Crafoord. However, to improve his skills he desired to travel abroad, and requested to be allowed to work under the supervision of the Swedish professor in his ward at the Sabbatsberg Hospital in Stockholm. Initial contacts and introductory letters seldom reveal the trajectory and outcomes of relationships and ensuing actions. Alascio’s is no excep- tion in this regard. Still, this apparently simple request might be also regarded as the starting point of the story I tell in this paper: how the Swedish surgeon Clarence Crafoord made four tours to South America. My overall goal is to unveil aspects of the design and execution of those tours, which partly planned, partly
    [Show full text]
  • Discovery and Purification of Heparin
    MILESTONES A transmission electron micrograph of an activated mast cell releasing granules containing heparin and histamine. Science Photo Library /Alamy Stock Photo MILESTONE 1 Discovery and purification of heparin Heparin was the first anticoagulant agent In 1922, Howell described an aqueous was used in a human for the first time: a saline to be discovered and isolated for medical extraction protocol and, in 1926, refined solution of heparin infused into the brachial use, and is one of the oldest drugs still to be this protocol and identified a water-soluble artery resulted in a significantly increased in widespread clinical use. Indeed, heparin polysaccharide anticoagulant, which he also clotting time, with no toxic adverse effects. remains on the WHO Model List of Essential termed ‘heparin’ (despite being different from A Swedish physiologist Erik Jorpes had vis- Medicines — the safest and most effective the compounds previously isolated in 1916 ited Best in Canada in 1929 and then returned medicines needed in a health-care system. and 1918). to the Karolinska Institute in Stockholm. In Heparin is a naturally occurring glycos- 1935, Jorpes published his research into the aminoglycan produced in the body by baso- heparin infused into structure of heparin, which allowed a Swedish phils and mast cells (image). The substance company to begin commercial production of was identified a centenary ago, although the brachial artery resulted heparin for intravenous use. By 1949, Peter who should be credited with the discovery in a significantly increased Moloney and Edith Taylor had patented a remains controversial. clotting time method to produce heparin with a high yield In 1916, Jay McLean was a second-year and at a low cost, which established the medical student working with the physiolo- widespread availability and use of the drug.
    [Show full text]
  • Periprocedural Prophylactic Antithrombotics in Arterial Procedures: the Road to Consensus
    Periprocedural prophylactic antithrombotics in arterial procedures: The road to consensus ... Arno M. Wiersema Periprocedural prophylactic antithrombotics in arterial procedures: The road to consensus… Periprocedurele profylactische antitrombotica in arteriële procedures: De weg naar consensus… (met een samenvatting in het Nederlands) Arno Mac Wiersema ! 1 ISBN 978-90-393-6136-8 App: Uitleg-video: http://vimeo.com/101308261 App design: Harm Ebben @ http://www.thesisapps.com Uitleg-video design: Kees Post & Matthijs Panhuis @ http://www.emations.nl Design of thesis: Kees Post @ www.keespost.nl Printing: GVO/Ponsen & Looijen @ www.proefschriften.nl Cover image: Painting of Zomer en Puck (daughters of author and his wife) on the beach of Los Angeles, on their road to consensus Painter: Paul Bruijninckx@ http://www.haagsekunstenaars.nl/cv/33330/Paul+Robbert+Bruijninckx Photography: Dr. Jeroen de Haan Financial support for research in this thesis was obtained by kind contributions from: Dr. G.J. van Hoytema Stichting W.L. Gore & Associates BV, Scovas Medical BV Excen BV: Wond Expertise Centra Nederland BV, Westfriesgasthuis Cook Medical, Medtronic NL BV, Angiodynamics, Lohmann & Rauscher Nederland BV, Lamepro BV Vascutek Nederland, Cordis-Johnson & Johnson BV, Angiocare BV, Chipsoft BV, Urgo Medical, Macquet Netherlands BV, Biotronik Nederland BV, B. Braun Medical BV, Spring Medical 2 Periprocedural prophylactic antithrombotics in arterial procedures: The road to consensus… Periprocedurele profylactische antitrombotica in arteriële procedures: De weg naar consensus… (met een samenvatting in het Nederlands) Proefschrift ter verkrijging van de graad van doctor aan de universiteit Utrecht op gezag van de rector magnificus, prof. dr. G.J. van der Zwaan, ingevolge het besluit van het college voor promoties in het openbaar te verdedigen op donderdag 4 september 2014 des middags te 2.30 uur door Arno Mac Wiersema geboren op 17 juli 1964 te Amsterdam 3 Promotor: Prof.
    [Show full text]
  • A Historical Look at the Department of Veterans Affairs Research and Development Program
    A Historical Look at the Department of Veterans Affairs Research and Development Program Acknowledgement to Author This book was compiled and written by Marguerite T. Hays, M.D., for the VA Office of Research & Development (ORD). ORD is grateful to the author, Dr. Hays, for her relentless work and dedication to make this publication possible. Her outstanding efforts as a physician, researcher, and writer have produced a lifetime of invaluable information about the inception of VA research. We are proud to present this book to the VA and non-VA community alike. Copyright Marguerite T. Hays, M.D. authored this book, at first in the course of her duties as a federal government employee, then as a contractor for the federal government. This book is hereby irrevocably dedicated to the public domain by the Department of Veterans Affairs and Marguerite T. Hays, M.D. This dedication is intended to be an overt act of relinquishment in perpetuity of all present and future rights under copyright law, whether vested or contingent. It is understood that relinquishment of all rights includes the relinquishment of all rights to enforce (by lawsuit or otherwise) those copyrights in this book. It is recognized that, once placed in the public domain, its works may be freely reproduced, distributed, transmitted, used, modified, built upon, or otherwise exploited by anyone for any purpose, commercial or non-commercial, and in any way, including by methods that have not yet been invented or conceived. Table of Contents Table of Contents i Preface iii Introduction iv Commonly Used Acronyms vi Part I, Ancestral roots, 1925-1945 1 1.
    [Show full text]
  • 1984/85:21 Redog. 1984/85:21
    Redog. 1984/85:21 Redogörelse 1984/85:21 Styrelsens för Stiftelsen Riksbankens jubileumsfond berättelse över fondens verksamhet och förvaltning under år 1984 1985-02-11 Till riksdagen Styrelsen för Riksbankens jubileumsfond får härmed avge berättelse över fondens verksamhet och förvaltning under år 1984. Ledamöter och suppleanter i styrelsen var vid årets utgång: professor Staffan Helmfrid (ordförande) suppleant: professor Inge Jonsson riksbankschefen Bengt Dennis (vice ordförande) suppleant: avdelningsdirektör Thomas Franzen riksdagsledamot Stig Gustafsson suppleant: riksdagsledamot Birger Rosqvist riksdagsledamot Helge Hagberg suppleant: riksdagsledamot Margit Sandehn riksdagsledamot Lars-Ingvar Sörenson suppleant: riksdagsledamot Margot Wallström riksdagsledamot Lars Ahlmark suppleant: riksdagsledamot Birger Hagård riksdagsledamot Gunnar Biörck suppleant: riksdagsledamot Hugo Hegeland ri ksdagsledamot Einar Larsson suppleant: riksdagsledamot Ulla Ekelund professor Leif Lewin suppleant: professor Ulf Olsson professor David Magnusson suppleant: professor David H. Ingvar professor Solveig Wikström suppleant: professor Jan Erik Kihlström Filosofie doktorn, docent Nils-Eric Svensson har under året varit fondens direktör och chef för dess kansli. l Riksdagen 1984185.2 samt. Nr 21 Redog. 1984/85:21 2 fondens uppgift Enligt sina stadgar har Riksbankens jubileumsfond till ändamål att främja och understödja till Sverige anknuten vetenskaplig forskning. Därvid gäller bl. a. att företräde skall ges åt forskningsområden, vilkas medelsbehov icke
    [Show full text]