Roshan COOLS Curriculum Vitae

PERSONAL DETAILS

Name: Prof. dr. Roshan Cools Address: Donders Centre for Cognitive Neuroimagiing, Kapittelweg 29, 6500 HB, Nijmegen Date and place of birth: 10/06/1975, Nijmegen Nationality: Dutch Birth country of parents: Email: [email protected]; Website: www.roshancools.com

AFFILIATIONS

Full Professor of Cognitive Neuropsychiatry Department of Psychiatry, Radboudumc Principle Investigator Motivational and Cognitive Control group, Donders Centre for Cognitive Neuroimaging Member Perception, Action and Control Theme, Donders Institute for Brain, Cognition and Behaviour Member Stress Disorders Theme, Radboudumc Member Advisory Council for Science, Technology and Innovation

EDUCATION

2003 Ph.D., Experimental Psychology, Univ Cambridge (10/05/2003). Title : ‘Parkinson’s disease as a model of -dependent fronto-striatal cognitive dysfunction’ 2000 M.Phil, Experimental psychology, Univ Cambridge UK (01/09/1999) 1998 M.A., Experimental psychology and neuropsychology Cum Laude (28/08/1998), Univ Groningen

WORK EXPERIENCE AND POSITIONS

2014-present Member of the Advisory Council of Science, Technology and Innovation 2011-present Full Professor of Cognitive Neuropsychiatry, Department of Psychiatry, Radboud University Medical Center, 2009-2011 Associate Professor, Department of Psychiatry, Radboud University Medical Center 2007-2009 Assistant Professor (tenured), Department of Psychiatry, Radboud University Medical Center 2007-present Principal Investigator, Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour Roshan COOLS Curriculum Vitae

2006-2007 Royal Society University Research fellow, University of Cambridge 2003-2005 Postdoctoral fellow, Helen Wills Neuroscience Institute, University of California, Berkeley 2002-20016 Royal Society Dorothy Hodgkin research fellow, University of Cambridge

Maternity leave April 2012-August 2012 Oct 2015 – February 2016

HONOURS AND RECOGNITIONS

2019 Member of F1000 2018 Elected Member of the Royal Netherlands Academy of Arts and Sciences (KNAW) Members the KNAW represent the full spectrum of scientific and scholarly endeavor and are selected on the basis of their scientific achievements. Members are appointed for life. 2018 Elected Member of the International Neuropsychological Society (INS) Promotes the international and interdisciplinary study of brain-behavioral relationships throughout the lifespan. 2018 Elected Member of the Academia Europaea The Academia Europaea is a European, non-governmental association academy of scientists and scholars who collectively aim to promote learning, education and research (2000 members, 40 Novel laureates). 2013 Fellow, Association for Psychological Science, UK Fellow status is awarded to APS members who have made sustained outstanding contributions to the science of psychology

SCIENTIFIC AWARDS AND PERSONAL FELLOWSHIPS

2017 KNAW Ammodo Award in Social Sciences This mid-career award is granted to individuals with outstanding scientific achievements and to support fundamental research 2015 Vici award from the Netherlands Organization for Scientific Research 2012 James McDonnell Scholar Award 2012 Young Investigator Award of the Cognitive Neuroscience Society 2011 Radboud Science Award for best research at Radboud University 2008 Vidi award from the Netherlands Organization for Scientific Research 2006 Royal Society University Research Fellowship, University of Cambridge UK 2002 Royal Society Dorothy Hodgkin Research Fellowship, University of Cambridge UK 2002 Junior Research Fellowship, St John’s College, Cambridge UK 2002 Human Frontiers Longterm Fellowship (declined) 1999 CD Marsden Studentship, Parkinson’s Disease Society of the UK 1999 Mary Ann Eward Studentship, Newnham College, Cambridge UK 1998 Cambridge European Trust Award, UK 1998 Dutch-British Partnership Award, Cambridge UK Roshan COOLS Curriculum Vitae

1998 MSc degree with Cum Laude

PERSONAL STATEMENT

Willpower. Scholars from a variety of disciplines have been fascinated by this phenomenon for centuries. It is considered to be one of the most distinct as well as most vulnerable aspects of the human mind. In psychology, it is a phenomenon intimately linked with functions such as cognitive control, motivation and choice. Cognitive control is an ill-defined term, but generally refers to the ability to direct our behaviour at our goals. A longstanding question concerns the driving force behind such goal-directed behaviour. What are the mechanisms by which we motivate ourselves to act in accordance with our goals? I have approached this question from a unique angle, studying effects of key brain chemicals, such as dopamine and serotonin.

CONTRIBUTION TO SCIENCE

I am in expert in chemical of human cognition and have approached timely questions about motivation, choice and cognitive control from a unique neuromodulatory angle, combining the most advanced, cutting-edge techniques for manipulating and quantifying the effects of dopamine and serotonin. Key specific breakthroughs include the discoveries that (i) dopamine can both enhance and undermine human cognitive control (compare dopamine’s role in the effects of smart drugs with that in drug addiction) (Cools and D’Esposito, 2011), (ii) effects of dopaminergic drugs depend on baseline levels of dopamine, improving cognition in low-dopamine subjects, but detrimentally overdosing cognition in high-dopamine subjects (Cools et al., 2009), (iii) individual differences in working memory capacity reflect individual variation in dopamine synthesis capacity (Cools et al., 2008), (iv) effects of reward motivation (the promise of reward) on human cognition depend on baseline dopamine levels, with low-dopamine subjects benefiting, but high-dopamine subjects being impaired by the promise of reward (Aarts et al., 2014), (v) effects of dopaminergic drugs depend on the target brain region, with striatal and prefrontal dopamine having opponent effects on the flexibility/stability tradeoff (Cools et al., 2007), (vi) smart drugs like methylphenidate improve cognitive stability but impair cognitive flexibility (Fallon et al., 2017) and (vii) dopaminergic drugs modulate cognitive control by changing the willingness rather than ability to exert control (Frobose et al., 2018).

In my earliest contribution, a publication in Cerebral Cortex in 2001, I put forward the ‘dopamine overdose hypothesis’ to account for the contrasting cognitive effects of dopaminergic medication in patients with Parkinson’s disease. I discovered that the dopaminergic medication doses that are necessary to remediate the motor deficits of Parkinson’s disease detrimentally overdose dopamine levels in relatively intact brain regions, such as the ventral striatum and prefrontal cortex, impairing key cognitive functions. Such discoveries, in particular on the behavioural role of the major ascending neuromodulators dopamine and serotonin, have provided important empirical foundations for current theoretical thinking and computational modelling work about dopamine and serotonin. In my so far best cited paper (2011 Biological Psychiatry, 854 cites), I summarize key principles of dopamine function derived from this empirical work, including the baseline-dependency and neurochemical Roshan COOLS Curriculum Vitae opponency principles. SUPERVISION Academic staff PhDs Promotor Ongoing 10 Completed 15 Total 25 Postdoc’s Ongoing 6 Completed 13 Total 19 Associate PIs Ongoing 1

Cools has personally mentored 25 PhD students (15 completed, 10 current), and 19 post-doctoral Commented [RC1]: Payam Piray Esther Aarts fellows (including 6 current). She also has 1 associated principal investigator associated with her group Martine van Schouwenburg (Esther Aarts). In addition, she has mentored 23 research master students towards completing their Marieke van der Schaaf Katinka von Borries major internship (with project durations ranging from 6 to 12 months). Martine Hoogman Mirjam Bloemendaal Lieneke Janssen PhD Students (Completed) Dirk Geurts Jasper Winkel Daniel von Rhein Name Supervision Year of Title of thesis Current Mieke van Holstein team completion position Verena Ly Monique Timmer Jennifer Swart

1. Esther Aarts Ardi Roelofs 2010 Resisting temptation. The Assistant Lieke Hofmans Monja Froboese Roshan Cools role of the anterior professor, Ruben van den Bosch cingulate cortex in Radboud Lieke van Lieshout Marpessa Rietbergen adjusting cognitive University, Sofie Brolsma control Nijmegen Annelies van Nuland

2. Martine van Roshan Cools 2012 Frontostriatal Postdoctoral Jorryt Schouwenburg Hanneke den mechanisms of fellow, Patricia Romero-Verdugo Ouden attentional control University of Danae Papadopetraki Amsterdam 3. Martine Barbara Franke 2013 Imaging the effects of Assistant Hoogman Jan Buitelaar ADHD risk genes professor, Roshan Cools Radboudumc Nijmegen 4. Katinka van Robbert Jan 2014 Carrots and sticks. A Clinical Borries Verkes neurobehavioral psychologist, Roshan Cools investigation of affective Germany outcome processing in 5. Daniel von Jan Buitelaar 2015 Neural mechanisms of Research Rhein Roshan Cools reward processing in scientist, attention- Radboudumc deficit/hyperactivity Nijmegen Roshan COOLS Curriculum Vitae

disorder

6. Marieke van Roshan Cools 2015 Dopaminergic Postdoctoral der Schaaf modulation of reward fellow, and punishment learning Radboudumc Nijmegen 7. Verena Ly Roshan Cools 2016 Affective biasing of Assistant Karin Roelofs instrumental action. How Professor, emotion shapes behavior University of Leiden 8. Desiree Robbert Jan 2016 Individual differences in Postdoctoral Spronk Verkes the acute effects of fellow, Roshan Cools cannabis and cocaine on University of cognitive control Oxford 9. Mieke van Roshan Cools 2016 Neural circuitry and Postdoctoral Holstein neurochemistry of fellow, motivated cognitive University of control British Columbia, Vancouver 10. Payam Piray** Roshan Cools 2016 Compute to learn. Neural Postdoctoral Ivan Toni implementation of fellow, computations underlying Radboudumc, associative learning and Nijmegen decision making. 11. Dirk Geurts Roshan Cools 2016 Translational psychiatry. Clinical and When affect motivates research effect psychiatrist, Radboudumc Nijmegen 12. Mirjam Esther Aarts 2016 Neural mechanisms of Clinical Studies Bloemendaal Roshan Cools cognitive control: Researcher, modulation by age and Danone dopamine Nutricia Research 13. Lieneke Esther Aarts 2016 Breaking bad habits - a Postdoctoral Janssen Roshan Cools meditation on the Fellow, Max neurocognitive Planck Institute mechanisms of Leipzig compulsive behavior 14. Monique Roshan Cools 2018 Out of balance: Clinical Timmer Rianne Esselink Neurocognitive Neurologist, Bas Bloem mechanisms underlying Dept depression in Parkinson's Neurology, disease Radboud Roshan COOLS Curriculum Vitae

University Medical Center, Nijmegen 15. Jennifer Hanneke den 2018 To go or not to go: On Data scientist at Swart** Ouden motivational biases in Centraal Roshan Cools decision making Bureau voor de Statistiek ** Cum laude

PhD Students (ongoing)

Name Supervision Team Planned Topic year of completion 16. Monja Frobose Roshan Cools 2019 Role of dopamine in motivational and cognitive control

17. Annelies van Nuland Rick Helmich 2019 Neurobiological, neurochemical Roshan Cools and cognitive mechanisms of Ivan Toni Parkinson's disease Hanneke den Ouden 18. Marpessa Rietbergen Ardi Roelofs 2020 Interactions between motor and Roshan Cools cognitive control

19. Sophie Brolsma Aarts Schene 2020 Neurocognitive mechanisms of Roshan Cools depression and autism)

20. Lieke van Lieshout Floris de Lange 2020 Neurocognitive mechanisms of Roshan Cools curiosity

21. Lieke Hofmans Roshan Cools 2021 Role of dopamine in the cost and benefit of cognitive control

22. Ruben van den Bosch Roshan Cools 2022 Role of dopamine in learning Jan Booij

23. Danae Papadopetraki Roshan Cools 2022 Too much control in Parkinson’s disease

24. Patricia Romero Roshan Cools 2022 Exploring the function and Verdugo Floris de Lange mechanisms of information seeking 25. Naomi de Haas Christian Doeller 2021 Navigating conceptual space Roshan Cools

Postdoctoral Fellows (Completed) Roshan COOLS Curriculum Vitae

Name Dates in the Cools lab Current position

1. Hanneke den 2009-2016 (funded by Associate Professor, Donders Centre for Cognition, Ouden my HFSP grant and Radboud University, Nijmegen own Veni fellowship) 2. Esther Aarts 2009-2016 (funded by Associate Principal Investigator, Donders Centre for own AXA and Veni Cognitive Neuroimaging fellowships) 3. Joost Wegman 2010-2018 (funded by Datascientist Rabobank our FOCOM and FCB grants) 4. Sean Fallon 2010-2014 (funded by Postdoctoral fellow (with Masud Husain), University my JSMF grant) of Oxford

5. Guillaume 2011-2017 (funded by Director of ‘cognitive neuroscience and behavioral Sescousse own Rubicon, DCCN addictions’ lab. Tenured researcher at the Centre and own NWO Veni de recherche en Neurosciences de Lyon (CNRS- fellowships) INSERM), Lyon 6. Martine van 2012-2013 (funded by Postdoctoral fellow, University of Amsterdam Schouwenburg my Vidi grant)

7. Jennifer Cook 2013-2014 (funded by Assistant Professor, Psychology, University of own AXA fellowship) Birmingham

8. Ruth van Holst 2014-2017 (funded Senior postdoctoral fellow (with Damiaan Denys), from personal NWO Dept of Psychiatry, Univ of Amsterdam Rubicon award and subsequently from my Vici award) 9. Romain Ligneul 2015-2017 (funded by Postdoctoral fellow (with Zach Mainen) at Fundacao own Fyssen fellowship) Champalimaud System Neuroscience Program, Lisbon, Portugal 10. Zheng Ye 2016 (funded by Peter Principal Investigator, Division of Mental Health and Hagoort) Behavior Genetics, Chinese Academy of Sciences, Beijing 11. Payam Piray 2016-2017 (funded by Postdoctoral fellow (with Nathaniel Daw), Dept my NWO Vici grant) Psychology, Princeton University

12. Andrew 2016-2017 (funded by Postdoctoral fellow (NRSA, with Michael Frank), Westbrook my NWO) Vici grant) Dept Psychology, Brown University, Providence

13. Eliana Vassena 2016-2019 (funded by Postdoctoral fellow (with Erno Hermans), Donders Marie Curie Individual Institute, Cognitive Neuroscience Dept, Fellowship) Radboudumc Nijmegen

Postdoctoral Fellows (Ongoing) Roshan COOLS Curriculum Vitae

Name Start date Funding

13. Bram Zandbelt 2014 Personal Marie Curie Individual Fellowship

15. Yingying Tan 2016 Funded by Peter Hagoort

16. Alya Vlassova 2018 Funded by Floris de Lange

17. Marieke van der 2019 Personal KWF research grant Schaaf

18. Ceyda Sayali 2019 My NWO Vici grant

19. Rebecca Calcott 2019 My KNAW Ammodo award

INTERNATIONAL ACTIVITIES

2005-2007 Royal Society university research fellow at the University of Cambridge, UK 2003-2005 Visiting postdoctoral research fellowship at the University of California, Berkeley, USA 1999-2003 PhD degree at the University of Cambridge, UK 1998-1999 M Phil degree at the University of Cambridge, UK, with a Dutch-British Partnership Award ‘Talent Program’ (1998)

International collaborations 2015 New York University, USA (Prof dr Liz Phelps, evidenced by joint publication Goldfarb et al., 2016) 2008-now Brown University, USA (Prof dr Michael Frank, who spent his sabbatical with us in 2015; collab evidenced by joint postdoc (Andrew Westbrook) and joint publications (e.g. Cools et al., 2009; Robinson et al., 2010; Swart et al., 2017) 2009-now University of Zurich, Switzerland (Dr. Quentin Huys, evidenced by joint publications in the Journal of Cognitive Neuroscience (Geurts et al., 2013), the Journal of Neuroscience (Geurts et al., 2013) and PloS Comput Biol (Huys et al., 2011)); 2011-2014 University of California, San Diego (Prof.dr. Adam Aron, evidenced by joint publication in the Journal of Cognitive Neuroscience (Chiu et al., 2014)) 2011 – now Washington University St Louis (Prof dr Deanna Barch; evidenced by joint publication Culbreth et al., 2016) 2009-2013 New York University, USA (Prof.dr. Nathanial Daw, formalized by Human Frontiers Program Grant, PI was Prof.dr. Kae Nakamura, and evidenced by joint publications in Neuropsychopharmacology (Cools et al., 2011) and Neuron (Den Ouden et al., 2013)); 2009-2013 Kansai Medical School, Japan (Prof Kae Nakamura, formalized by Human Frontiers Program Grant, PI was Prof Kae Nakamura, and evidenced by joint publications in Roshan COOLS Curriculum Vitae

Neuropsychopharmacology (Cools et al., 2011)); 2007-2013 University of Oxford, UK (Prof Matthew Rushworth and Dr Jacinta O’Shea, evidenced by joint publication in the Journal of Neuroscience (Van Schouwenburg et al., 2012)); 2006-2011 University of California, Berkeley (formal co-PI on NIH RO1 grant; formal collaborator on NIH Programme grant with PIs Prof.dr. Mark D’Esposito, Prof.dr. Rich Ivry, Prof.dr. William Jagust; Prof Joni Wallis); 1999 – now University of Cambridge, UK (; joint publications)

Roshan COOLS Curriculum Vitae

Other academic activities

Scientific Memberships 2018-present Elected Member, Royal Netherlands Academy of Arts and Sciences (KNAW) 2018-present Elected Member, International Neuropsychological Symposium (INS) 2016-present Elected Member, Academia Europaea (Section Behavioural Sciences) 2014-present Member, (Government) Advisory Council for Science and Technology Policy, NL 2012-present Member, Board of the Rathenau Institute (research, debate on Science and Technology) 2010,2014 Member, Rubicon grant selection Committees (Social Sciences), Netherlands Organisation for Scientific Research 2017 Member, Vidi grant selection committee (social sciences), NWO 2011-present Member, Advisory Council Attention and Performance, US 2012 – 2014 Contributor to Research Network “A Roadmap on Mental Health Research in Europe”, EU 2011-present Member, PI Selection Committee, Radboudumc, NL 2008 - 2013 Member, Steering Committee of 1 of 4 Themes (‘Perception, Action and Control’) at Donders Institute, Radboud University, NL 2008-2017 Member, Education Committee, Radboud University, NL 2008 – 2012 Member, Research Infrastructure Committee, Radboud University, NL 2013-present Fellow, Association for Psychological Science, UK 2003-present Member, Society for Neuroscience, US 2003-present Member, Cognitive Neuroscience Society, US

Conference Organisation 2019 Organizer of the international conference on Control Processes, Brown University, Providence 2017 Organizer of the international conference on Control Processes, Amsterdam 2017 Chair symposium at NVP ‘Motivation for effort: Neuro-computational mechanisms, physiology and social dynamics’ 2016 Founder and organizer of the international conference on Control Processes, UC San Diego 2016 Chairperson Symposium on Dopamine and Cognition, Dopamine 2016, Vienna, Austria 2015 Organiser of Summerschool on Computational Approaches to Decision Making, Donders Inst, NL 2014 Organiser of Symposium on Ageing, Donders Inst, Radboud University, NL 2010 Organiser and chairperson of Symposium at 7th Forum European Neuroscience (FENS), EU 2006 Organizer, Symposium Annual Meeting of the Cognitive Neuroscience Society, US

Editorial services 2019-present Member of the Cognitive Neuroscience section of F1000Prime 2017-present Reviewing Editor, Journal of Neuroscience 2017-present Editor, Computational Psychiatry 2014-present Member, Editorial Board Current Opinion in Behavioral Sciences 2010-present Active Editor, Journal of Cognitive Neuroscience Roshan COOLS Curriculum Vitae

2017-2018 Guest Editor, Special Issue on Cognitive Effort, Neuropsychologia 2014-2017 Editor, Royal Society Open Science 2014-2015 Member, Editorial Board Motivation Science 2012 – 2014 Associate Editor, special issue Frontiers Behavioral Neuroscience 2009 – now Consulting Editor, Cognitive, Affective, & Behavioral Neuroscience 2003 – now Regular grant reviewer for Dutch, UK, US and other funding agencies (e.g NWO, FWO, DFG, Welcome Trust etc) 2001– now Regular journal reviewer for Nat Commun, Curr Biol, Elife, Neuron, Brain, Science and many other journals

Search committees 2019 Chair: Professor of Developmental Neuroscience, Radboudumc 2019 Member: Professor of Clinical Neuropsychiatry, Radboudumc 2018 Member: Principle Investigator Systems Neurosci, Donders Inst Brain, Cogn and Behav 2018 Member: Professor of Nuclear Medicine, Radboud University Medical Center 2017 Member: Professor First Language Acquisition, Radboud University 2017/2019 Member: Professor of Biostatistics, Radboud University Medical Center 2013/2014 Member: Head of Department of Neurology, Radboud University Medical Center 2011 Member: Professor Functional Imaging Analysis, Dept of Radiology, Radboudumc 2011 Member: Professor of Child Neurology, Radboudumc 2011 Member: Professor Clinical Neurophysiology, Radboudumc

Doctoral thesis/Defense Committees 2018 Jeroen Verharen, ‘Neuroeconomic mechanisms of reward and aversion’ Univ Utrecht (regular member) 2018 Sophie Akkermans, ‘The role of the frontostriatal circuitry in impulsive and compulsive syndromes’, Radboudumc (chair) 2017 Freek Nieuwhof, ‘The complexity of walking. Cognitive control of gait in aging and Parkinson’s disease’, Radboudumc (chair) 2017 Linda de Voogd, ‘Do you remember what you did last summer? On the formation and alteration of memories for stressful experiences’ Radboudumc (regular member) 2017 Raimon Pruim, ‘ Disentangling the functional architecture of the brain in psychiatric disorders’, Radboudumc (chair) 2016 Elexa St John-Saaltink, ‘When the past influences the present: Modulations of the sensory response by prior knowledge and task set’, Radboud University (regular member) 2016 Jesper Hopstaken, Univ Leiden (regular member) 2016 Lizanne Schweren, ‘Stimulants and the developing brain’, Univ Groningen (regular member) 2016 Linda Boekhoudt, ‘Behavioural effects of chemogenetic dopamine neuron activation’, Univ Utrecht (regular member) 2016 Stella de Wit, ‘In the Loop: Neuroimaging Cognitive Control in Obsessive-Compulsive Disorder’, Free Univ Amsterdam (regular member) 2016 Ruud van Zessen, ‘Dopamine neuronal activity and food seeking’, Univ Utrecht, (regular member) 2015 Janita Bralten, Radboudumc (chair) 2015 Mathias Ekman, Radboud University (chair) Roshan COOLS Curriculum Vitae

2015 Chris Vriend (regular member) 2014 Gail Alvares, ‘Autonomic and Behavioural Inflexibility in Social Anxiety Disorder’, University of Sydney (regular member) 2014 Marlies van Bochove, Univ Gent (regular member 2013 Inti Brazil, Radboud Univ (regular member) 2013 Cathelijne Thesink, Radboud Univ (regular member0 2013 Henk Cremers, Radboudumc 2013 Jannelle van Wel, Radboudumc 2013 Martijn Figee, Univ Amsterdam 2013 Sarah Jahfari, Univ Amsterdam 2013 Zsuzika Sjoerds, Free Univ Amsterdam 2012 Marijn Kroes, Raboudumc (chair) 2011 Henk van Steenbergen, Univ Leiden (regular member) 2011 Bram Zandbelt, Univ Utrecht (regular member) 2011 Lindsey Ossewaarde, Radboud Univ 2011 Amy Bilderbeck, Univ Oxford 2011 Giorgio Tommasi, Univ Verona 2010 Geoffrey van der Plasse, Univ Amsterdam 2010 Shaozeng Qin, Radboudumc 2009 Edita Poljac, Rdboud Univ 2009 Janneke Koertz, Univ Groningen 2009 Van Leijenhorst, Univ Leiden 2009 Ruth van Holst, Univ Amsterdam

Grants and scholarships Total amount of grants: >€ 9.400,000

Grant, scholarship, prize Role Amount Year of award KNAW Ammodo Award Sole PI €300,000 2017 (5 yrs) KNAW Sole PI €6.000 2015 Congressubsidiefonds Vici grant (NWO) Sole PI €1.500.000 2015 (5 yrs) James McDonnell Scholar Sole PI $600,000 (USD)= 2012 (6 yrs) Award €452,000 Hersenstichting fellowship Sole PI €150,000 2009 (2 yrs) Vidi (+ Aspasia) grant Sole PI €700,000 2008 (5 yrs) (MagW, NWO) Royal Society University Sole PI £481,939 (GBP)= 2006 (5 yrs) Research Fellowship (Royal €603,000 Society of London) Royal Society Dorothy Sole PI £118,174 (GBP) = 2002 (4 yrs) Hodgkin Research €148,000 Fellowship (Royal Society of London) Human Frontiers Science Sole PI Full fellowship 2002 (3 yrs) (declined Program Long Term after receipt Dorothy Fellowship Hodgkin fellowship) Roshan COOLS Curriculum Vitae

Research Talent grant PI €177,362 2014 (3 yrs) (Social Sciences, NWO) AGIKO grant (Social PI €63,530 2011 (3 yrs) Sciences, NWO) Open competition grant PI € 209,513 2010 (4 yrs) (Social Sciences, NWO) Parkinson’s Disease Society PI £ 10,000 (GBP)= 2007 (1 yr) Fast Track Grant (Parkinson € 12,500 Disease Society of the UK) Subtotal >€ 4.315.905 Internal competition Co-PI ±€ Donders Centre for 200,000 Medical Neuroscience with Rick Helmich, Radboudumc junior researcher round 2019 DI Internal TopTalent PhD Supervisor € 240,000 grant (Patricia Romero Verdugo) DI Internal Toptalent PhD Supervisor € 240,000 2015 (4 yrs) grant (Lieke van Lieshout) Internal competition PhD Co-PI ±€ 200,000 2014 (4 yrs) grant Donders Centre for Neuroscience with Aart Schene Internal competition PhD Co-PI € 340,000 2013 (3 yrs) grant Gravitation Programme Language in Interaction with Ardi Roelofs International Parkinson’s Co-PI € 187,500 2012 (3 yrs) disease Foundation Research Grant with Rianne Esselink and Bas Bloem FOCOM Consortium Grant Co-PI € 1.360,000 2012 (3 yrs) (Europees Fonds voor Regionale Ontwikkeling) Open Competition Grant Co-PI € 208,000 2011 (4 yrs) (Social Sciences, NWO) Human Frontiers Research Co-PI $ 1.000,000 (USD)= 2009 (4 yrs) Program grant € 755,000 Open competition grant Co-PI € 238,000 2009 (4 yrs) (Life Sciences, NWO) RO1 grant National Institute Co-PI $ 1.459,498 (USD) = 2006 (4 yrs) of Health € 1.101,570 Roshan COOLS Curriculum Vitae

American Parkinson’s Co-PI $ 50,000 (USD)= 2004 (1 yr) Disease Association € 37,738 Research Grant Subtotal >€5.107,5 Fellowship of the Recipient Nonstipendary 2013 Association for Psychological Science Young Investigator Award of Recipient $500 (USD) 2012 the Cognitive Neuroscience Society Radboud Science Award for Recipient €10,000 2011 (1 yr) best research at Radboud University Nijmegen (Wetenschapsknooppunt RadboudUMC Nijmegen) Junior Research Title A Recipient Nonstipendary 2002 (3 yrs) Fellowship fellowship CD Marsden Full Recipient Full studentship 1999 (3 yrs) studentship (Parkinson’s (amount unknown) Disease Society of the UK) Mary Anne Eward Award Recipient Full studentship 1999 (3 yrs) (Newnham College (amount unknown) Cambridge) Cambridge European Trust Recipient €500 1998 Award Dutch-British Partnership Recipient Full studentship 1998 (1 yr) Award ‘Talent Program’ (amount unknown) (1998) (British Council & Nuffic) Subtotal € 10.876 Total >€ 9.434,400

Roshan COOLS Curriculum Vitae

OUTPUT Total # refereed publications: 139 Citations (per 11-10-2018): 13,015 H-index googlescholar(per 11-10-2018): 53

A Thomson Reuters InCites analysis confirmed Roshan Cools’ substantial impact. Her articles are cited more than 2.5 times as often as papers of her peers world-wide, while the proportion of her articles in the categories top-1% and top-10% mostly cited is almost six times respectively more than four times above the average within her field of research.

Publications (refereed, non-refereed, professional, public, other) See separate document

Invited presentations at international conferences/schools > 80

11/2019 Glasgow departmental seminar series Fall/2019 Affective Brain seminar series, Univ College London 09/2019 Motivational and Cognitive Control meeting, Berlin 09/2019 Computational Cognitive Neuroscience, Berlin 07/2019 Research seminar, Wellcome Centre for Integrative Neuroimaging (WIN) at University of Oxford 06/2019 Keynote lecture OHBM, Rome, Italy 05/2019 Control Processes, Brown Univ, Providence 03/2019 Decision making workshop, Cosyne, Cacais Portugal 03/2019 Serotonin workshop, Cosyne, Cascais Portugal 02/2019 Computational Psychiatry working group meeting, Barbury Center at Cold Spring Harbor 01/2019 Department seminar series, Dept of Experimental Psychology, Univ Oxford 10/2018 Computational Properties of the Prefrontal Cortex, Vanderbilt Univ, Nashville 08/2018 Keynote lecture. Imaging@Brisbane Conference (declined) 07/2018 Symposium talk. European Society for Cognitive and Affective Neuroscience. Leiden 06/2018 8th Summer School in Cognitive Neuroscience, International Max Planck Research School on Neuroscience of Communication (IMPRS NeuroCom) at the Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig 06/2018 2nd Treatment Selection Idea Lab (TSIL2018), University College London 06/2018 Dusseldorf Symposium on Decision Neuroscience. 06/2018 Symposium talk on intellectual doping. Dutch Neuroscience meeting, Lunteren 01/2018 The Institute for Brain and Behaviour Amsterdam (iBBA) lecture series. Faculty of Behavioural and Human Movement Sciences of the VU of Amsterdam. 01/2018 Symposium talk. Winter Conference on Brain Research (WCBR) Annual Meeting, Whistler Canada. 10/2017 Keynote speaker. Brain Prize Meeting 2017. Rewarding Neuroscience. 08/2017 Computational Psychiatry Course, the Translational Neuromodeling Unit (TNU), Zürich 06/2017 FENS SfN summer school on Chemical Neuromodulation, Bertorinoro Italy Roshan COOLS Curriculum Vitae

02/2017 Department seminar series, Dept Psychology, Univ Birmingham 09/2016 Dopamine workshop, UCL Gatsby Computational Neuroscience Unit, London, UK 09/2016 Dopamine 2016, Vienna, Austria 08/2016 6th Motivational and Cognitive Control Meeting, St Andrews, Scotland, UK 06/2016 International Neuropsychologia Symposium 2016, Baiona, Spain 06/2015 Reward, Motivation and Dopamine, EPFL Brain Mind Symposium Lausanne 04/2015 British Neuroscience Association, Edinburgh 03/2015 Oxford outcome prediction workshop Nick Yeung 9/2014 Computational Psychiatry and Aging, Schloss Ringberg Germany 08/2014 Enhancing Responsibility Project conference, Technical University Delft 06/2014 European Open Form Neuroenhancement, Copenhagen Denmark 05/2014 4th International symposium on the biology of decision making, Paris 04/2014 Seminar series, Laboratory for Social and Neural Systems Research University of Zurich 03/2014 2nd Dresden Spring School on Cognitive-Affective Neuroscience; Technical University Dresden 01/2014 Bernstein Centre Berlin 10/2013 Reinforcement Learning Decision Making workshop Princeton 10/2013 Neuroeconomics Seminar NYU (Glimcher, Phelps etc) 10/2013 Rutgers Newark Departmental seminar (Gluck) 05/2013 Mechanisms of Motivation, Cognition, and Aging Interactions (MOMCAI), Washington Univ, St Louis 04/2013 Keynote lecture Annual Meeting Cognitive Neuroscience Society, San Francisco, US 05/2013 Dopamine 2013, Alghero, Italy 02/2013 Neuroenhancement meeting, Bochum Germany 11/2012 3rd International Symposium on Prefrontal Cortex, Kyoto, Japan 11/2012 ESF-FENS Conference ‘The Neurobiology of Emotion’, Stresa, Italy 12/2011 Keynote. Nederlandse Vereniging voor Psychonomie, Egmond aan Zee 07/2011 11th Intern’l Conference on Cognitive Neuroscience (ICON XI), Mallorca, Spain 06/2011 The Movement Disorders Society, Toronto, ON, Canada 03/2011 Symposium, UC Berkeley 02/2011 Ernst Strüngmann Forum on Cognitive Search, Frankfurt 12/2010 7th Internat’l Congress, Mental Dysfunctions in Parkinson’s Disease, Barcelona 12/2010 American College Neuropsychopharmacology Plenary Lecture, Miami Florida 11/2010 Annual meeting, Society for Neuroscience. Minisymposium speaker; San Diego 09/2010 Decision Neuroscience Workshop. MPI for Human Development, Berlin 08/2010 9th Charité Conference on Psychiatric Research: Emotional Neuroscience, Berlin 06/2010 7th Forum of European Neuroscience (FENS). Symposium speaker; Amsterdam 06/2010 FENS-IBRO Summer School 2010. Speaker; Dubrovnik 05/2009 Annual symposium, MIT McGovern Inst Brain Research, Boston 04/2009 Behavioural neurobiology lab seminar; ETH Zurich 02/2009 Annual Cosyne (Computational and systems neuroscience) meeting; Workshop ‘ The computational role of dopamine’, Salt Lake City 01/2009 Departmental seminar, Institute of Movement Neurosciences, Queen Square London Roshan COOLS Curriculum Vitae

12/2008 Departmental seminar, Centre de Neurosciences Cognitives, Lyon 10/2008 Departmental seminar, Department of Psychology, Aberdeen UK 09/2008 International Conference on Cognitive Neuroscience, Bodrum Turkey 08/2008 ECNP Targeted Expert Meeting on addiction; Invited discussant; Barcelona 07/2008 Human Brain Mapping; Melbourne Australia (declined) 07/2008 Attention and Performance XXIII on decision making; Stowe, Vermont 07/2008 Friday Seminar; Nederlands Institute for Neuroscience Amsterdam; 4 July 2008 06/2008 Dutch Endo-Neuro-Psycho meeting; Doorwerth, 4-6 June 2008 05/2008 Workshop Neurocognitive Approaches to Control and Working Memory; Leiden; 29 May 2008 05/2008 Workshop The Attentive Speaker; Nijmegen; 8-9 May 2008 03/2008 Departmental seminar; Institute for Empirical Research in Economics, University of Zurich 02/3008 Wednesday lunchtime seminar; MRC Cognition and Brain sciences Unit Cambridge 12/2007 LIBC Colloquiem; Departmental seminar; Leiden 12/2007 Aging and dementia symposium; Douglas Institute Montreal Canada 06/2007 Workshop ‘Theoretical and Experimental Perspectives on Serotonin Function’, Lisbon Portugal 05/2007 Society for Biological Sciences, Cambridge UK 06/2006 British Association for Psychopharmacology, Oxford 07/2006 Mental Dysfunction in Parkinson’s Disease, Amsterdam 03/2006 Chair and speaker of symposium on dopamine at the Cognitive Neuroscience Annual Meeting 2005 Departmental seminar, Psychology and Neuroscience, Rutgers Univ? 10/2004 Annual Meeting, Memory Disorders Research Society, New York 2004 Lab seminar, Brian Knutson’s group Stanford 2002 Sackler Institute, New York

TEACHING

2007-present I have mentored 23 research master students (Cognitive Neuroscience, Biomedical Sciences, Medical Biology, Medicine, Biology Psychology) towards completing their major research internship (with project durations ranging from 6 to 12 months).

2014-present I serve as regular independent mentor of PhD students or early career scientists seeking advice (during a number of years) across disciplines and across campuses, for example in the context of the Radboud University Mentor Program (currently 3 mentees at research institutes with which I am not affiliated), or the Bielefeld University Commented [RC2]: Nina Belei, Anke van Mil, Tamara Woezik mentoring program movement (1 mentee) Commented [RC3]: Nienke Debats

Lectures and courses 2017-present Lecture. ‘Geluksneuronen en -’ Interdisciplinary, university-wide bachelor course on Gelukkig Leven. 4 hours per year. 2017-present Coordinator and lecturer. Faculty of Medical Sciences. Biomedical Science research master-level course on ‘Higher-order Cognition and Emotion’. 3EC Roshan COOLS Curriculum Vitae

2014-2017 Lecture and assignment. Medical Faculty. Medical bachelor level course: 5KNW2 Neurobiologie en Psychiatrie. 60 hours per year 2014-2015 Lecture. Medical Faculty. Medical bachelor level course ‘Capita Selecta’ (4 hours per year) 2013-present Coordinator and lecturer. Faculty of Social Sciences. Cognitive Neuroscience research master-level course on ‘Cognitive Control and Decision Making’. 6EC 2013-2017 Coordinator Donders Toolkit ‘Advanced functional neuroimaging analyses’ (2 weeks per year) 2008-2017 Coordinator and lecturer. Faculty of Social Sciences. Cognitive Neuroscience research master-level course on ‘Neuroimaging II. fMRI in practice’. 14 hours per year 2011-2012 Program director Honours Masters Programme ‘Wider implications of Neuroscience: Human enhancement’ 2010-2014 Lecture ‘Frontal lobe function in neuropsychiatry’. Research master level course ‘Cognitive neuroscience of memory’. 4 hours per year. 2011-present Lecture and assignment ‘Affective and decision functions of serotonin’. Cognitive Neuroscience Research master level course ‘Trends in Cognitive Neurosciences’ 2010 Guest lectures. Ghent University. 10 hours. 2009-2010 Guest Lectures. University of Maastricht. Psychology Bachelor level course ‘Neuroscience of action. 4 hours per year. 2007-2009 Guest Lecture. Faculty of Natural Sciences and Maths. Bachelor-level course ‘How the brain works’. 4 hours per year

OUTREACH ACTIVITIES I combine my basic science expertise with clinical and societal interests, evidenced by my active membership of the Advisory Council for Science, Technology and Innovation (AWTI), which advises the Dutch government on STI policy. I am also a board member of the KNAW Rathenau Institute, which promotes the formation of political and public opinion on STI. My commitment to public engagement is further evidenced by regular (i) activities via social and regular media (www.roshancools.com), (ii), public lectures, consider for example her TedX talk in 2013 on trust in basic science and most recently her talks at the 2018 Betweter Festival in Utrecht and the 2018 PhD Day in Utrecht; and (ii) primary school activities. My work tackles two EU "Grand Challenges”: (a) promoting innovation in society and (b) advancing personalized health. Finally, her work will have implications for educational policy and science, because failures of (motivated) cognitive control in the context of education can have life-long consequences. Currently, I am working on developing a proxy-model of dopamine for individualized risk-profiling and predicting dopaminergic drug effects. In this context, I have had various consulting contracts with pharmaceutical (Abbvie and Pfizer) and food industry.

Memberships of councils/boards 2014 - now Member, Advisory Council for Science, Technology and Innovation, NL 2012 – now Member, Board of the Rathenau Institute (research, debate on Science and Technology), NL

Invited public lectures 10/2018 Speaker Betweter Festival, Tivoli Vredenburg & Studium Generale, Utrecht 09/2018 Speaker 2018 PhD day Groningen, Oosterpoort 09/2018 Speaker/discussant. Who’s afraid of Neuroscience. Lux, Nijmegen 10/2017 KNAW symposium “Freud and Neuroscience anno 2017” Roshan COOLS Curriculum Vitae

09/2017 Speaker ‘Donders meets Education 2017’ 03/2017 Speaker ‘Professoren op het Podium’, theater Orpheus, Apeldoorn 02/2017 Discussant Reuring!Café (with Mark Frequin), Glazen Zaal, Den Haag 12/2016 Speaker 5e Kenniscongres Stoornissen, Reehorst Ede 10/2016 Science Café Wageningen on ‘Addiction: A Disease of Free Will?’ 09/2016 Speaker Rathenau Institute ‘Local Ethics for Global Technology’ 09/2016 Chairperson steeringcommittee on ‘Balans van de Wetenschap’ (Rathenau, AWTI) 06/2015 Radboud Research Round 03/2015 NVH lezing Lindenberg 11/2014 Speaker ParkinsonNet Congres 2014 10/2014 Mystery X (Science4Kids) lecture (link) 06/2014 Speaker ESOF 2014 Copenhagen Euroscience Open Forum, DM, (link) 03/2014 Science Café on ‘Brain Doping’, Nijmegen, NL, (link) 02/2014 Public lecture, Soeterbeeck Programme, Nijmegen,‘Gij Zult Impulsief Zijn’ (link) 10/2013 Public Lecture Radboud University Alumni, Radboud University, NL (link) 12/2013 Discussant at the Symposium Cognitive Neuroscience: Science, society and policy makers, Rathenau Institute visits Radboud University, NL 05/2013 Talk at TedXRadboudU ‘Trusting Science’, Radboud University, NL (link) 05/2013 Public Lecture or 90 primary school children at RadboudKids, Meet the Professor, Radboud University, NL 09/2011 Guest contribution to the Social Sciences Council, advising the Royal Science Academy of NL on the topic of Cognitive Enhancement (Sept 2011); 2009 Studium Generale, Maastricht University

Other outreach activities 07/2018 Organized public dissemination workshop at labretreat for training supervisees 09/2018 Followed public speaking training by theatre maker Ruud Moesbergen in preparation for Betweter festival 02/2017 Discussiesessie OCW. Kennisagenda 11/2013 Followed NWO media training course ‘Spread the News’ by ElroyCOM

Selection of media coverage See www.roshancools.com/blog

Television: 04/2015 NOSop3 Breindoping 02/2015 Kennis van Nu. ‘Het afgeleide Brein’ 03/2010 Nieuwslicht TV Ned3, Ritalin als pepmiddel? link

Internet: 05/2018 Psychology Today. On our paper on curiosity: https://www.psychologytoday.com/us/blog/our-innovating- minds/201805/why-do-you-ask 2015 Various online-media in 2015 in relation to the Vici award, see www.roshancools.com/blog 11/2014 People Behind The Science Podcast with Marie McNeely 2015 (link) Roshan COOLS Curriculum Vitae

02/2014 Various online-media in February 2014 in relation to our Psych Sci paper, e.g. (e.g. http://www.kijkopkennis.nl/wp/) 12/2013 Notes & Theories. Dispatches from the science desk of The Guardian. ‘ In praise of uncertainty’(link) 11/2013 Various online-media in relation to our Neuron paper (e.g. ‘Who learns from the carrot, and who from the stick?’ AlphaGalileo (link)) 03/2012 Socialevraagstukken.nl ‘De psychiatrie is toe aan vernieuwing’ (link) 03/2013 Science Guide 02/2013 Various online-media in January-March 2012 in relation to my inaugural lecture, (e.g. Eos magazine opiniestuk ‘De psychiatrie is toe aan vernieuwing’) Radio: 2015 EenVandaag. In verband met Vici award 02/2014 Radio 5, NTR Academie, in relation to Soeterbeeck Preeck 03/2012 Radio 1 Labyrinth RC with Damiaan Denys 10/2012 Radio 1 ‘Onderzoek: De hersenen van een gokker’ http://www.radio1.nl/items/63054-onderzoek- de-hersenen- van-een-gokker 08/2012 Radio 5 Hoe?Zo! Zesde aflevering van de serie ‘Wetenschap in de familie’ waarin Hoe?Zo! Radio familiebanden van academici onder de loep neemt (augustus 2012); Lex en Roshan Cools (link) 02/2009 Radio 5 Hoe?Zo! Radio NTR met Karin Roelofs ‘Vernieuwing in de psychiatrie’ (februari 2012); http://www.wetenschap24.nl/programmas/hoezo- radio/Uitzendingen/2012/februari/08-02-2012-Vernieuwing-in-de- psychiatrie.html 02/2009 Interview for Radio 1 ‘De Praktijk’ on ‘de slotvraag’ published article over gambling in Neuron

Music: 09/2015 Inspiratiebron voor Kinderen voor kinderen 35: ‘M’n hart slaat sneller dan ik rennen kan’. Door Christiaan Coenraadts

Newspapers, magazines and books: 10/2018 Nominated for Viva 400 Topwomen 07/2018 LEF Magazine. https://www.lef-magazine.nl/nieuws/actueleverslavingsnieuws/amc-gok-en drugsverslaving-wezenlijk-anders 12/2017 Interview met Elsevier maandblad ‘Juist’ met Elisabeth Wytzes. 05/2017 Interview voor maandblad ‘Psychologie’ met Door Malou van Hintum. “Laat je eens vaker afleiden” 09/2016 Interview voor boek ‘IMPACT! VIA DE NIEUWSMEDIA. Een HOE-en DOE Boek voor wetenschappers. ElroyCOM uitgeverij. 2015 Interview voor boek ‘Kijken in het brein: mythen en mogelijkheden‘. Authors: Sandra van Aalderen, Meike Grol en Nienke van Atteveldt 06/2015 NWO Quest 03/2014 ‘Ontdoel’. Interview voor de Volkskrant – Sir Edmund Bijlage - met Iante Sahadat (link) 11/2013 De Telegraaf, katern gezondheid ‘Straf en Beloning’. Roshan COOLS Curriculum Vitae

11/2012 Zin. ‘Prof. dr. leuker leven’

11/2012 Genomineerd Viva 400 Topvrouwen onder de 40.

10/2012 Viva. ‘Single, moeder, professor’. 01/2012 Volkskrant ‘Een pil slaat niet altijd aan’ Malou van Hintum 04/2012 Glamour. ‘Woman of the month’. 11/2011 De Psychonoom (link) 12/2008 Interview met Malou van Hintum in het kenniskatern van De Volkskrant over ‘Geluk en het brein’ 10/2008 Interview in blad voor hoogbegaafde kinderen

University newspapers: 10/2108 Vox ‘De Relaxte professorenbuurt’ (https://www.voxweb.nl/nieuws/de-relaxte- professorenbuurt) 11/2013 Radboudnews (link) 02/2012 ‘Uitgelicht’ RadboudMagazine 01/2012 Vox ‘In de toga van opa’ (link) 2012 Radbode/alumniblad