DOCSLIB.ORG

Roshan COOLS Curriculum Vitae

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Roshan COOLS Curriculum Vitae Roshan COOLS Curriculum Vitae PERSONAL DETAILS Name: Prof. dr. Roshan Cools Address: Donders Centre for Cognitive Neuroimagiing, Kapittelweg 29, 6500 HB, Nijmegen Date and place of birth: 10/06/1975, Nijmegen Nationality: Dutch Birth country of parents: Netherlands Email: [email protected]; Website: www.roshancools.com AFFILIATIONS Full Professor of Cognitive Neuropsychiatry Department of Psychiatry, Radboudumc Principle Investigator Motivational and Cognitive Control group, Donders Centre for Cognitive Neuroimaging Member Perception, Action and Control Theme, Donders Institute for Brain, Cognition and Behaviour Member Stress Disorders Theme, Radboudumc Member Advisory Council for Science, Technology and Innovation EDUCATION 2003 Ph.D., Experimental Psychology, Univ Cambridge (10/05/2003). Title thesis: ‘Parkinson’s disease as a model of dopamine-dependent fronto-striatal cognitive dysfunction’ 2000 M.Phil, Experimental psychology, Univ Cambridge UK (01/09/1999) 1998 M.A., Experimental psychology and neuropsychology Cum Laude (28/08/1998), Univ Groningen WORK EXPERIENCE AND POSITIONS 2014-present Member of the Advisory Council of Science, Technology and Innovation 2011-present Full Professor of Cognitive Neuropsychiatry, Department of Psychiatry, Radboud University Medical Center, 2009-2011 Associate Professor, Department of Psychiatry, Radboud University Medical Center 2007-2009 Assistant Professor (tenured), Department of Psychiatry, Radboud University Medical Center 2007-present Principal Investigator, Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour Roshan COOLS Curriculum Vitae 2006-2007 Royal Society University Research fellow, University of Cambridge 2003-2005 Postdoctoral fellow, Helen Wills Neuroscience Institute, University of California, Berkeley 2002-20016 Royal Society Dorothy Hodgkin research fellow, University of Cambridge Maternity leave April 2012-August 2012 Oct 2015 – February 2016 HONOURS AND RECOGNITIONS 2019 Member of F1000 2018 Elected Member of the Royal Netherlands Academy of Arts and Sciences (KNAW) Members the KNAW represent the full spectrum of scientific and scholarly endeavor and are selected on the basis of their scientific achievements. Members are appointed for life. 2018 Elected Member of the International Neuropsychological Society (INS) Promotes the international and interdisciplinary study of brain-behavioral relationships throughout the lifespan. 2018 Elected Member of the Academia Europaea The Academia Europaea is a European, non-governmental association academy of scientists and scholars who collectively aim to promote learning, education and research (2000 members, 40 Novel laureates). 2013 Fellow, Association for Psychological Science, UK Fellow status is awarded to APS members who have made sustained outstanding contributions to the science of psychology SCIENTIFIC AWARDS AND PERSONAL FELLOWSHIPS 2017 KNAW Ammodo Award in Social Sciences This mid-career award is granted to individuals with outstanding scientific achievements and to support fundamental research 2015 Vici award from the Netherlands Organization for Scientific Research 2012 James McDonnell Scholar Award 2012 Young Investigator Award of the Cognitive Neuroscience Society 2011 Radboud Science Award for best research at Radboud University 2008 Vidi award from the Netherlands Organization for Scientific Research 2006 Royal Society University Research Fellowship, University of Cambridge UK 2002 Royal Society Dorothy Hodgkin Research Fellowship, University of Cambridge UK 2002 Junior Research Fellowship, St John’s College, Cambridge UK 2002 Human Frontiers Longterm Fellowship (declined) 1999 CD Marsden Studentship, Parkinson’s Disease Society of the UK 1999 Mary Ann Eward Studentship, Newnham College, Cambridge UK 1998 Cambridge European Trust Award, UK 1998 Dutch-British Partnership Award, Cambridge UK Roshan COOLS Curriculum Vitae 1998 MSc degree with Cum Laude PERSONAL STATEMENT Willpower. Scholars from a variety of disciplines have been fascinated by this phenomenon for centuries. It is considered to be one of the most distinct as well as most vulnerable aspects of the human mind. In psychology, it is a phenomenon intimately linked with functions such as cognitive control, motivation and choice. Cognitive control is an ill-defined term, but generally refers to the ability to direct our behaviour at our goals. A longstanding question concerns the driving force behind such goal-directed behaviour. What are the mechanisms by which we motivate ourselves to act in accordance with our goals? I have approached this question from a unique angle, studying effects of key brain chemicals, such as dopamine and serotonin. CONTRIBUTION TO SCIENCE I am in expert in chemical neuromodulation of human cognition and have approached timely questions about motivation, choice and cognitive control from a unique neuromodulatory angle, combining the most advanced, cutting-edge techniques for manipulating and quantifying the effects of dopamine and serotonin. Key specific breakthroughs include the discoveries that (i) dopamine can both enhance and undermine human cognitive control (compare dopamine’s role in the effects of smart drugs with that in drug addiction) (Cools and D’Esposito, 2011), (ii) effects of dopaminergic drugs depend on baseline levels of dopamine, improving cognition in low-dopamine subjects, but detrimentally overdosing cognition in high-dopamine subjects (Cools et al., 2009), (iii) individual differences in working memory capacity reflect individual variation in dopamine synthesis capacity (Cools et al., 2008), (iv) effects of reward motivation (the promise of reward) on human cognition depend on baseline dopamine levels, with low-dopamine subjects benefiting, but high-dopamine subjects being impaired by the promise of reward (Aarts et al., 2014), (v) effects of dopaminergic drugs depend on the target brain region, with striatal and prefrontal dopamine having opponent effects on the flexibility/stability tradeoff (Cools et al., 2007), (vi) smart drugs like methylphenidate improve cognitive stability but impair cognitive flexibility (Fallon et al., 2017) and (vii) dopaminergic drugs modulate cognitive control by changing the willingness rather than ability to exert control (Frobose et al., 2018). In my earliest contribution, a publication in Cerebral Cortex in 2001, I put forward the ‘dopamine overdose hypothesis’ to account for the contrasting cognitive effects of dopaminergic medication in patients with Parkinson’s disease. I discovered that the dopaminergic medication doses that are necessary to remediate the motor deficits of Parkinson’s disease detrimentally overdose dopamine levels in relatively intact brain regions, such as the ventral striatum and prefrontal cortex, impairing key cognitive functions. Such discoveries, in particular on the behavioural role of the major ascending neuromodulators dopamine and serotonin, have provided important empirical foundations for current theoretical thinking and computational modelling work about dopamine and serotonin. In my so far best cited paper (2011 Biological Psychiatry, 854 cites), I summarize key principles of dopamine function derived from this empirical work, including the baseline-dependency and neurochemical Roshan COOLS Curriculum Vitae opponency principles. SUPERVISION Academic staff PhDs Promotor Ongoing 10 Completed 15 Total 25 Postdoc’s Ongoing 6 Completed 13 Total 19 Associate PIs Ongoing 1 Cools has personally mentored 25 PhD students (15 completed, 10 current), and 19 post-doctoral Commented [RC1]: Payam Piray Esther Aarts fellows (including 6 current). She also has 1 associated principal investigator associated with her group Martine van Schouwenburg (Esther Aarts). In addition, she has mentored 23 research master students towards completing their Marieke van der Schaaf Katinka von Borries major internship (with project durations ranging from 6 to 12 months). Martine Hoogman Mirjam Bloemendaal Lieneke Janssen PhD Students (Completed) Dirk Geurts Jasper Winkel Daniel von Rhein Name Supervision Year of Title of thesis Current Mieke van Holstein team completion position Verena Ly Monique Timmer Jennifer Swart 1. Esther Aarts Ardi Roelofs 2010 Resisting temptation. The Assistant Lieke Hofmans Monja Froboese Roshan Cools role of the anterior professor, Ruben van den Bosch cingulate cortex in Radboud Lieke van Lieshout Marpessa Rietbergen adjusting cognitive University, Sofie Brolsma control Nijmegen Annelies van Nuland 2. Martine van Roshan Cools 2012 Frontostriatal Postdoctoral Jorryt Schouwenburg Hanneke den mechanisms of fellow, Patricia Romero-Verdugo Ouden attentional control University of Danae Papadopetraki Amsterdam 3. Martine Barbara Franke 2013 Imaging the effects of Assistant Hoogman Jan Buitelaar ADHD risk genes professor, Roshan Cools Radboudumc Nijmegen 4. Katinka van Robbert Jan 2014 Carrots and sticks. A Clinical Borries Verkes neurobehavioral psychologist, Roshan Cools investigation of affective Germany outcome processing in psychopathy 5. Daniel von Jan Buitelaar 2015 Neural mechanisms of Research Rhein Roshan Cools reward processing in scientist, attention- Radboudumc deficit/hyperactivity Nijmegen Roshan COOLS Curriculum Vitae disorder 6. Marieke van Roshan Cools 2015 Dopaminergic Postdoctoral der Schaaf modulation of reward fellow, and punishment learning Radboudumc Nijmegen 7. Verena Ly Roshan Cools 2016 Affective biasing of Assistant Karin Roelofs instrumental action. How Professor, emotion
Load more

Recommended publications
  • Aberrant Reward Processing in Parkinson's Disease Is Associated with Dopamine Cell Loss
    NeuroImage 59 (2012) 3339–3346 Contents lists available at SciVerse ScienceDirect NeuroImage journal homepage: www.elsevier.com/locate/ynimg Full-length Article Aberrant reward processing in Parkinson's disease is associated with dopamine cell loss Esther Aarts a,b,⁎,1, Rick C. Helmich a,c,1, Marcel J.R. Janssen a,d, Wim J.G. Oyen a,d, Bastiaan R. Bloem a,c, Roshan Cools a,b a Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behavior, Kapittelweg 29, 6525 EN Nijmegen, The Netherlands b Radboud University Nijmegen Medical Centre, Department of Psychiatry, Reinier Postlaan 10, 6525 GC Nijmegen, The Netherlands c Radboud University Nijmegen Medical Centre, Department of Neurology, Parkinson Centre Nijmegen (ParC), Reinier Postlaan 4, 6525 GC Nijmegen, The Netherlands d Radboud University Nijmegen Medical Centre, Department of Nuclear Medicine, Geert Grooteplein 8, 6525 GA Nijmegen, The Netherlands article info abstract Article history: Dopamine has been implicated in reward-related impulsivity, but the exact relationship between dopamine, Received 3 August 2011 reward and impulsivity in humans remains unknown. We address this question in Parkinson's disease (PD), Revised 14 November 2011 which is characterized by severe dopamine depletion. PD is associated primarily with motor and cognitive Accepted 24 November 2011 inflexibility, but can also be accompanied by reward-related impulsivity. This paradoxical symptom of PD Available online 6 December 2011 has often been attributed to dopaminergic overstimulation by antiparkinson medication, which is necessary to relieve the motor and cognitive inflexibility. However, factors other than medication may also contribute Keywords: fl Impulsivity to aberrant impact of reward. Here we assess whether cognitive in exibility and aberrant reward impact in Dopamine PD are two sides of the same coin, namely dopamine cell loss.
    [Show full text]
  • Striatal Dopamine and the Interface Between Motivation and Cognition
    REVIEW ARTICLE published: 14 July 2011 doi: 10.3389/fpsyg.2011.00163 Striatal dopamine and the interface between motivation and cognition Esther Aarts1*, Mieke van Holstein 2 and Roshan Cools 2,3 1 Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA 2 Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands 3 Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands Edited by: Brain dopamine has long been known to be implicated in the domains of appetitive motivation Wim Notebaert, Ghent University, and cognition. Recent work indicates that dopamine also plays a role in the interaction between Belgium appetitive motivation and cognition. Here we review this work. Animal work has revealed an Reviewed by: K. Richard Ridderinkhof, University of arrangement of spiraling connections between the midbrain and the striatum that subserves a Amsterdam, Netherlands mechanism by which dopamine can direct information flow from ventromedial to more dorsal Patrick Santens, Gent University, regions in the striatum. In line with current knowledge about dopamine’s effects on cognition, Belgium we hypothesize that these striato-nigro-striatal connections provide the basis for functionally *Correspondence: specific effects of appetitive motivation on cognition. One implication of this hypothesis is Esther Aarts, Helen Wills Neuroscience Institute, University of California at that appetitive motivation
    [Show full text]
  • Visiting KNAW Professor from Newcastle University
    78 BCN - School for Behavioral and Cognitive Neurosciences june 2010 Interview with prof. dr. Daniel Nettle Visiting KNAW professor from r Newcastle University e Could you shortly introduce yourself? My name is Daniel Nettle. I am a behavioural scientist t from Newcastle University and I am a KNAW visiting professor this year, here in the Psychology Department. t I am here for some time now, but the KNAW professorship allows me to make several visits during the year, so I will be back later this year. e In my career, I started out as an anthropologist, but then I went to psychology and now I work in neuroscience. l For me, the fundamental issues are: How do we understand human behaviour; what part of behaviour comes from the situation people are in and what s part comes from the properties of the individual; the way their brain is set up. Whichever way you study behaviour, it is going to involve many disciplines, like biology, psychology, neuroscience, anthropology. When I worked on different problems concerning behaviour, w it just was easier to be attached to different institutes. You cannot isolate psychology from anthropology, neuroscience and biology. It is all kind of a mixture. e they live in. The ways we have of deciding in such Can you tell us about your research? questions will have been subject to natural selection My recent work is on reproductive decisions, specifically over many thousands of years. how do we decide when to have a baby. Do you have your first baby at 18 or 28 and if you have had one, Do you see that as a conscious decision? how long do you keep breastfeeding and when do you I think it is a funny old mixture.
    [Show full text]
  • Serotonergic Modulation of Prefrontal Cortex During Negative Feedback in Probabilistic Reversal Learning
    Neuropsychopharmacology (2005) 30, 1138–1147 & 2005 Nature Publishing Group All rights reserved 0893-133X/05 $30.00 www.neuropsychopharmacology.org Serotonergic Modulation of Prefrontal Cortex during Negative Feedback in Probabilistic Reversal Learning 1 ,2,3 3 1 1 Elizabeth AT Evers , Roshan Cools* , Luke Clark , Frederik M van der Veen , Jelle Jolles , 4 3 Barbara J Sahakian and Trevor W Robbins 1Brain and Behavior Institute, University of Maastricht, Maastricht, The Netherlands; 2Department of Psychology, University of California, 3 4 Berkeley, CA, USA; Department of Experimental Psychology, University of Cambridge, Cambridge, UK; Department of Psychiatry, Addenbrooke’s Hospital, Cambridge, UK This study used functional magnetic resonance imaging to examine the effects of acute tryptophan (TRP) depletion (ATD), a well- recognized method for inducing transient cerebral serotonin depletion, on brain activity during probabilistic reversal learning. Twelve healthy male volunteers received a TRP-depleting drink or a balanced amino-acid drink (placebo) in a double-blind crossover design. At 5 h after drink ingestion, subjects were scanned while performing a probabilistic reversal learning task and while viewing a flashing checkerboard. The probabilistic reversal learning task enabled the separate examination of the effects of ATD on behavioral reversal following negative feedback and negative feedback per se that was not followed by behavioral adaptation. Consistent with previous findings, behavioral reversal was accompanied by significant signal change in the right ventrolateral prefrontal cortex (PFC) and the dorsomedial prefrontal cortex. ATD enhanced reversal-related signal change in the dorsomedial PFC, but did not modulate the ventrolateral PFC response. The ATD-induced signal change in the dorsomedial PFC during behavioral reversal learning extended to trials where subjects received negative feedback but did not change their behavior.
    [Show full text]
  • CNS 2013 Program
    Cognitive Neuroscience Society 20th Annual Meeting, April 13-16, 2013 Hyatt Regency Hotel, San Francisco, California 2013 Annual Meeting Program Contents 2013 Committees & Staff . 2 Schedule Overview . 3 Keynotes. 5 George A. Miller Prize. 7 Distinguished Career Contributions Award . 8 Young Investigator Award . 9 General Information. 12 Exhibitors . 15 Invited-Symposium Sessions. 16 Mini-Symposium Sessions . 23 Poster Schedule . 31 Poster Session A . 32 Poster Session B . 62 Poster Session C . 92 Poster Session D . 121 Poster Session E . 151 Poster Session F . 180 Poster Session G . 209 Poster Session H . 238 Poster Topic Index . 267 Author Index . 269 Hyatt Regency Floorplan . 280 A Supplement of the Journal of Cognitive Neuroscience Cognitive Neuroscience Society c/o Center for the Mind and Brain 267 Cousteau Place, Davis, CA 95616 ISSN 1096-8857 © CNS www.cogneurosociety.org 2013 Committees & Staff Governing Board Mini-Symposium Committee Roberto Cabeza, Ph.D., Duke University Elizabeth Kensinger, Ph.D., Boston College (Chair) Marta Kutas, Ph.D., University of California, San Diego David Badre, Ph.D., Brown University Helen Neville, Ph.D., University of Oregon Clayton Curtis, Ph.D., New York University Daniel Schacter, Ph.D., Harvard University Lila Davachi, Ph.D., New York University Michael S. Gazzaniga, Ph.D.,University of California, Scott Huettel, Ph.D., Duke University Santa Barbara (ex offi cio) Gina Kuperberg, Ph.D., Harvard University George R. Mangun, Ph.D., University of California, Kia Nobre, Ph.D., University of Oxford Davis (ex offi cio) Thad Polk, Ph.D., University of Michigan Patti Reuter-Lorenz, Ph.D., University of Michigan (ex offi cio) Marty Woldorff, Ph.D., Duke University Program Committee Young Investigator Award Committee George R.
    [Show full text]
  • Decomposing Effects of Dopaminergic Medication in Parkinson’S Disease on Probabilistic Action Selection – Learning Or Performance?
    European Journal of Neuroscience European Journal of Neuroscience, Vol. 35, pp. 1144–1151, 2012 doi:10.1111/j.1460-9568.2012.08043.x Decomposing effects of dopaminergic medication in Parkinson’s disease on probabilistic action selection – learning or performance? P. Smittenaar,1 H. W. Chase,2 E. Aarts,3 B. Nusselein,4 B. R. Bloem5 and R. Cools4,6 1The Wellcome Trust Centre for Neuroimaging, University College London, London, UK 2Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA 3Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA 4Donders Institute for Brain, Cognition and Behavior, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, The Netherlands 5Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands 6Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands Keywords: decision-making, dopamine, reinforcement learning, valence, value-based performance Abstract Dopamine has long been implicated in reward-based learning and the expression of such learned associations on performance. Robust evidence supports its effects on learning and performance, but teasing these apart has proved challenging. Here we have adapted a classic test of value-based learning, the probabilistic selection task, to disentangle effects of dopamine on value-based performance from effects on value-based learning. Valence-specific effects of dopamine on this specific task cannot be accounted for by modulation of learning, and therefore must reflect modulation of performance. We found that dopaminergic medication, consisting of levodopa and ⁄ or dopamine agonists taken at own dose, in 18 patients with mild Parkinson’s disease (Hoehn and Yahr < 2.5) potentiated reward-based approach in terms of both accuracy and reaction times, while leaving punishment-based avoidance unaffected.
    [Show full text]
  • CNS-2020-Program-Booklet.Pdf
    Cognitive Neuroscience Society 27th Annual Meeting, March 14-17, 2020 Sheraton Hotel, Boston, Massachusetts Contents 2020 Committees & Staff………………………………. 2 Schedule Overview……………………………………... 3 Code of Conduct………………………………………... 8 Keynote………………………………………………….. 9 George A Miller Prize………………………………….. 10 The Fred Kavli Distinguished Career 11 Contributions Award………………………………….... Young Investigator Award…………………………….. 12 Workshops & Special Events…………………..…….. 13 Special Session…………………………………….….. 14 Data Blitz Sessions...………………………………….. 16 General Information……………………………….…... 19 Invited-Symposium Sessions………………………… 21 Symposium Sessions…………………………………. 26 Exhibits……………………………………………….… 44 GSA/PFA Awards………………………………….….. 44 Poster Schedule……………………………………..… 45 • Poster Session A…………………………… 45 • Poster Session B…………………………… 51 • Poster Session C…………………………… 57 • Poster Session D…………………………… 63 • Poster Session E…………………………… 69 • Poster Session F…………………………… 75 Advertisements……………………………………...… 7, 9, 84 A Supplement of the Journal of Cognitive Neuroscience Cognitive Neuroscience Society c/o Center for the Mind and Brain 267 Cousteau Place, Davis, CA 95616 ISSN 1096-8857 © CNS www.cogneurosociety.org 2020 Committees & Staff Governing Board Art Shimamura, Ph.D., University of California, Berkeley Marie Banich, Ph.D., University of Colorado at Boulder Roberto Cabeza, Ph.D., Duke University CNS Trainee Association (CNSTA) Marta Kutas, Ph.D., University of California, San Diego Alexandra (Lesya) Gaynor, Memorial Sloan Kettering George R. Mangun, Ph.D., University
    [Show full text]
  • Li Eke Van Lieshou T the Cognitive and Neural Mechanisms of Information
    Lieke van Lieshou t The cognitive and neural mechanisms of information seeking DONDERS SE RIES Radboud University ltJ Radboudumc O e_; -ttJN6·� LIEKE VAN LIESHOUT Why so curious? The cognitive and neural mechanisms of information seeking Why so curious? The cognitive and neural mechanisms of information seeking Coverdesign | Floortje Bouwkamp Opmaak | Proefschriftenbalie, Michel Wolf Print | Ipskamp Printing ISBN 978-94-6421-206-8 © Lieke van Lieshout (2021) Why so curious? The cognitive and neural mechanisms of information seeking Proefschrift ter verkrijging van de graad van doctor aan de Radboud Universiteit Nijmegen op gezag van de rector magnificus prof. dr. J.H.J.M. van Krieken, volgens besluit van het college van decanen in het openbaar te verdedigen op woensdag 9 juni 2021 om 14.30 uur precies door Lieke Lucia Francisca van Lieshout geboren op 1 februari 1991 te Geldrop Promotoren Prof. dr. Roshan Cools Prof. dr. Floris P. de Lange Manuscriptcommissie Prof. dr. Alan G. Sanfey Prof. dr. Sabine Hunnius Dr. Matthias J. Gruber (Cardiff University, Verenigd Koninkrijk) Contents CHAPTER 1 9 General introduction CHAPTER 2 33 Curiosity varies with uncertainty, but not with expected value of information CHAPTER 3 49 Induction and relief of curiosity elicit parietal and frontal activity CHAPTER 4 73 Curiosity or savouring? Information seeking is modulated by both uncertainty and valence CHAPTER 5 115 Curiosity: An appetitive or an aversive drive? CHAPTER 6 139 Does dopamine synthesis capacity predict individual variation in curiosity? CHAPTER 7 165 General discussion Nederlandse samenvatting 187 Acknowledgements 195 About the author 201 List of Publications 202 Data Research Management 203 Donders Graduate School for Cognitive Neuroscience 204 CHAPTER 1 General introduction This chapter is adapted from: van Lieshout, L.L.F., de Lange, F.P., & Cools, R.
    [Show full text]
  • Learning Jennifer L Cook1*, Jennifer C Swart2, Monja I Frobo¨ Se2, Andreea O Diaconescu3,4,5, Dirk EM Geurts2,6, Hanneke EM Den Ouden2†, Roshan Cools2,6†
    RESEARCH ARTICLE Catecholaminergic modulation of meta- learning Jennifer L Cook1*, Jennifer C Swart2, Monja I Frobo¨ se2, Andreea O Diaconescu3,4,5, Dirk EM Geurts2,6, Hanneke EM den Ouden2†, Roshan Cools2,6† 1School of Psychology, University of Birmingham, Birmingham, United Kingdom; 2Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, Netherlands; 3Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland; 4Department of Psychiatry, University of Basel, Basel, Switzerland; 5Krembil Centre for Neuroinformatics,CAMH, University of Toronto, Toronto, Canada; 6Department of Psychiatry, Radboud University Medical Centre, Nijmegen, Netherlands Abstract The remarkable expedience of human learning is thought to be underpinned by meta- learning, whereby slow accumulative learning processes are rapidly adjusted to the current learning environment. To date, the neurobiological implementation of meta-learning remains unclear. A burgeoning literature argues for an important role for the catecholamines dopamine and noradrenaline in meta-learning. Here, we tested the hypothesis that enhancing catecholamine function modulates the ability to optimise a meta-learning parameter (learning rate) as a function of environmental volatility. 102 participants completed a task which required learning in stable phases, where the probability of reinforcement was constant, and volatile phases, where probabilities changed every
    [Show full text]
  • A Balancing Act with Dopamine
    high da: stable prefrontal cortex dopamine: cognitive stability low da: distractible functional and neurochemical reciprocity low da: inflexible striatum dopamine: cognitive flexibility high da: flexible A balancing act with dopamine Human beings are extremely capable of adapting to their constantly aim to provide more insight into this proc- changing environment. But often we need to ignore those changes, ess, with the ultimate aim of understanding stay as we are, and continue acting as normal. So how do we know the neurobiological basis of neuropsychiat- when it’s appropriate to change our behaviour and how do we balance ric disorders such as ADHD and Parkinson’s fl exibility and stability? Roshan Cools is working on the hypothesis disease. One characteristic of these disorders that this is mediated by the brain substance dopamine, which regu- is a neurochemical imbalance, leading to in- lates the dynamic interaction between two regions of the brain. flexibility, impulsivity and/or compulsivity. We hope that our approach will eventually lead to individualized treatment strategies that target the complex cognitive deficits ‘Things developed so quickly’, Cools associated with these conditions. ’ observes, referring to her position as Prin- cipal Investigator at the Donders Institute, Two interacting regions where she started only two years ago, ‘We appear to need both cognitive flexibility soon after which she obtained a NWO and stability. If we’re too flexible, we tend Vidi grant. ‘There are fourteen people in to be distracted and our behaviour becomes my group if I include my affiliated and unstable and, if we’re too stable, we become Master’s students,’ she says.
    [Show full text]
  • Stratified Medicine for Mental Disorders Gunter Schumann, Elisabeth B
    Author's Accepted Manuscript Stratified Medicine for Mental Disorders Gunter Schumann, Elisabeth B. Binder, Arne Holte, E.Ronald de Kloet, Ketil J. Oedegaard, Trevor W. Robbins, Tom R. Walker-Tilley, Verity J. Brown, Jan Buitelaar, Roberto Ciccocioppo, Roshan Cools, Carles Escera, Wolfgang Fleischhacker, Herta Flor, Chris D. Frith, Andreas Heinz, Erik Johnsen, Clemens Kirschbaum, Torkel Klingberg, Klaus-Peter www.elsevier.com/locate/euroneuro Lesch, Shon Lewis, Wolfgang Maier, Karl Mann, Jean-Luc Martinot, Andreas Meyer-Lindenberg, Christian P. Müller, Walter E. Müller, David J. Nutt, Antonio Persico, Giulio Perugi, Mathias Pessiglione, Ulrich W. Preuss, Jonathan P.Roiser, Paolo M. Rossini, Janusz K. Rybakowski, Carmen Sandi, Klaas E. Stephan, Juan Undurraga, Eduard Vieta, Nic van der Wee, Til Wykes, Josep Maria Haro, Hans Ulrich Wittchen PII: S0924-977X(13)00276-9 DOI: http://dx.doi.org/10.1016/j.euroneuro.2013.09.010 Reference: NEUPSY10731 To appear in: European Neuropsychopharmacology Received date: 19 June 2013 Revised date: 9 September 2013 Accepted date: 26 September 2013 Cite this article as: Gunter Schumann, Elisabeth B. Binder, Arne Holte, E.Ronald de Kloet, Ketil J. Oedegaard, Trevor W. Robbins, Tom R. Walker-Tilley, Verity J. Brown, Jan Buitelaar, Roberto Ciccocioppo, Roshan Cools, Carles Escera, Wolfgang Fleischhacker, Herta Flor, Chris D. Frith, Andreas Heinz, Erik Johnsen, Clemens Kirschbaum, Torkel Klingberg, Klaus-Peter Lesch, Shon Lewis, Wolfgang Maier, Karl Mann, Jean-Luc Martinot, Andreas Meyer- Lindenberg, Christian P. Müller, Walter E. Müller, David J. Nutt, Antonio Persico, Giulio Perugi, Mathias Pessiglione, Ulrich W. Preuss, Jonathan P. Roiser, Paolo M. Rossini, Janusz K. Rybakowski, Carmen Sandi, Klaas E.
    [Show full text]
  • Rational Inattention and Tonic Dopamine
    bioRxiv preprint doi: https://doi.org/10.1101/2020.10.04.325175; this version posted October 5, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Rational Inattention and Tonic Dopamine John G. Mikhael1;2∗, Lucy Lai1, Samuel J. Gershman3 1Program in Neuroscience, Harvard Medical School, Boston, MA 02115 2MD-PhD Program, Harvard Medical School, Boston, MA 02115 3Department of Psychology and Center for Brain Science, Harvard University, Cambridge, MA 02138 ∗Corresponding Author Correspondence: john [email protected] 1 bioRxiv preprint doi: https://doi.org/10.1101/2020.10.04.325175; this version posted October 5, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. 1 Abstract 2 Slow-timescale (tonic) changes in dopamine (DA) contribute to a wide variety of processes in reinforce- 3 ment learning, interval timing, and other domains. Furthermore, changes in tonic DA exert distinct 4 effects depending on when they occur (e.g., during learning vs. performance) and what task the subject 5 is performing (e.g., operant vs. classical conditioning). Two influential theories of tonic DA|the average 6 reward theory and the Bayesian theory in which DA controls precision|have each been successful at 7 explaining a subset of empirical findings. But how the same DA signal performs two seemingly distinct 8 functions without creating crosstalk is not well understood. Here we reconcile the two theories under the 9 unifying framework of `rational inattention,' which (1) conceptually links average reward and precision, 10 (2) outlines how DA manipulations affect this relationship, and in so doing, (3) captures new empirical 11 phenomena.
    [Show full text]