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Stratified Medicine for Mental Disorders Gunter Schumann, Elisabeth B

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Stratified Medicine for Mental Disorders Gunter Schumann, Elisabeth B Author's Accepted Manuscript Stratified Medicine for Mental Disorders Gunter Schumann, Elisabeth B. Binder, Arne Holte, E.Ronald de Kloet, Ketil J. Oedegaard, Trevor W. Robbins, Tom R. Walker-Tilley, Verity J. Brown, Jan Buitelaar, Roberto Ciccocioppo, Roshan Cools, Carles Escera, Wolfgang Fleischhacker, Herta Flor, Chris D. Frith, Andreas Heinz, Erik Johnsen, Clemens Kirschbaum, Torkel Klingberg, Klaus-Peter www.elsevier.com/locate/euroneuro Lesch, Shon Lewis, Wolfgang Maier, Karl Mann, Jean-Luc Martinot, Andreas Meyer-Lindenberg, Christian P. Müller, Walter E. Müller, David J. Nutt, Antonio Persico, Giulio Perugi, Mathias Pessiglione, Ulrich W. Preuss, Jonathan P.Roiser, Paolo M. Rossini, Janusz K. Rybakowski, Carmen Sandi, Klaas E. Stephan, Juan Undurraga, Eduard Vieta, Nic van der Wee, Til Wykes, Josep Maria Haro, Hans Ulrich Wittchen PII: S0924-977X(13)00276-9 DOI: http://dx.doi.org/10.1016/j.euroneuro.2013.09.010 Reference: NEUPSY10731 To appear in: European Neuropsychopharmacology Received date: 19 June 2013 Revised date: 9 September 2013 Accepted date: 26 September 2013 Cite this article as: Gunter Schumann, Elisabeth B. Binder, Arne Holte, E.Ronald de Kloet, Ketil J. Oedegaard, Trevor W. Robbins, Tom R. Walker-Tilley, Verity J. Brown, Jan Buitelaar, Roberto Ciccocioppo, Roshan Cools, Carles Escera, Wolfgang Fleischhacker, Herta Flor, Chris D. Frith, Andreas Heinz, Erik Johnsen, Clemens Kirschbaum, Torkel Klingberg, Klaus-Peter Lesch, Shon Lewis, Wolfgang Maier, Karl Mann, Jean-Luc Martinot, Andreas Meyer- Lindenberg, Christian P. Müller, Walter E. Müller, David J. Nutt, Antonio Persico, Giulio Perugi, Mathias Pessiglione, Ulrich W. Preuss, Jonathan P. Roiser, Paolo M. Rossini, Janusz K. Rybakowski, Carmen Sandi, Klaas E. Stephan, Juan Undurraga, Eduard Vieta, Nic van der Wee, Til Wykes, Josep Maria Haro, Hans Ulrich Wittchen, Stratified Medicine for Mental Disorders, European Neuropsychopharmacology, http://dx.doi.org/10.1016/j.euroneuro.2013.09.010 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. StratifiedMedicineforMentalDisorders EditedbyGunterSchumannandHansUlrichWittchen Gunter Schumann1*+, Elisabeth B. Binder2*, Arne Holte3*, E. Ronald de Kloet4*, Ketil J. Oedegaard5*,TrevorW.Robbins6*,TomR.WalkerTilley1*,VerityJ.Brown7,JanBuitelaar8, Roberto Ciccocioppo9, Roshan Cools10, Carles Escera11, Wolfgang Fleischhacker12, Herta Flor13, Chris D. Frith14, Andreas Heinz15, Erik Johnsen5, Clemens Kirschbaum16, Torkel Klingberg17, KlausPeter Lesch18, Shon Lewis19, Wolfgang Maier20, Karl Mann21, JeanLuc Martinot22,AndreasMeyerLindenberg13,ChristianP.Müller23,WalterE.Müller24,DavidJ. Nutt25, Antonio Persico26, Giulio Perugi27, Mathias Pessiglione28, Ulrich W. Preuss29, JonathanP.Roiser30,PaoloM.Rossini31,JanuszK.Rybakowski32,CarmenSandi33,KlaasE. Stephan34,JuanUndurraga35,EduardVieta35,NicvanderWee36,TilWykes37,JosepMaria Haro38andHansUlrichWittchen39* 1MRCRSGDPCentre,InstituteofPsychiatry,King’sCollegeLondon,UK2MaxPlanckInstitute of Psychiatry, Munich, Germany 3Norwegian Institute of Public Health, Oslo, Norway 4Department of Endocrinology and Metabolism, Leiden University Medical Centre and MedicalPharmacology,LACDR,LeidenUniversity,TheNetherlands 5DepartmentofClinical Medicine, Section of Psychiatry, University of Bergen and Psychiatric division, Health R Bergen,Norway 6BehaviouralandClinicalNeuroscienceInstitute,UniversityofCambridge, Cambridge, UK 7Department of Psychology, University of St Andrews, St Andrews, UK 8Department of Cognitive Neuroscience, University Medical Center, St Radboud and Karakter Child and Adolescent Psychiatry University Center, Nijmegen, The Netherlands 9Department of Experimental Medicine and Public Health, University of Camerino, Camerino,Macerata,Italy10DondersInstitute,Nijmegen,TheNetherlands11Departmentof Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain 12Department of Psychiatry and Psychotherapy, Medical University Innsbruck, Innsbruck, Austria 13Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health,MedicalFacultyMannheim,HeidelbergUniversity,Mannheim,Germany14Wellcome 1 Trust Centre for Neuroimaging, University College London, London, UK 15Berlin School of Mind and Brain, Bernstein Center for Computational Neuroscience (BCCN), Clinic for PsychiatryandPsychotherapy,Charité–Universitätsmedizin,Berlin,Germany16Technische Universität Dresden, Department of Psychology, Dresden, Germany 17Cognitive Neuroscience, KarolinskaInstitutet, Stockholm, Sweden 18Division of Molecular Psychiatry, LaboratoryofTranslationalNeuroscience,UniversityofWürzburg,Würzburg,Germanyand Department of Neuroscience, School of Mental Health and Neuroscience (MHENS), MaastrichtUniversity,Maastricht,TheNetherlands19UniversityofManchester,Manchester, UK 20Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany 21Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Mannheim,Germany 22Institut National dela Santéet de laRechercheMédicale, INSERM CEA Unit 1000 “Imaging & Psychiatry”, University Paris Sud, Orsay, and APHP Department of Adolescent Psychopathology and Medicine, Maison de Solenn, University Paris Descartes, Paris, France 23Psychiatric University Hospital, FriedrichAlexander University ErlangenRNuremberg, Erlangen, Germany UK 24Department of Pharmacology, Biocenter Niederursel, University of Frankfurt, Frankfurt, Germany 25NeuropsychopharmacologyUnit,DivisionofBrainSciences,ImperialCollege,London,UK 26 Child and Adolescent Neuropsychiatry Unit & Laboratory of Molecular Psychiatry and Neurogenetics, University Campus BioMedico, Rome, Italy 27Department of Psychiatry, UniversityofPisa,Pisa,Italy28InstitutduCerveauetdelaMoelleépinière(ICM),Hôpitalde la PitiéSalpêtrière, Paris, France 29Department of Psychiatry, Psychotherapy and Psychosomatics, MartinLutherUniversity of HalleWittenberg, Halle/Saale, Germany 30InstituteofCognitiveNeuroscience,UniversityCollegeLondon,London,UK31Department ofGeriatrics,Neuroscience&Orthopaedics,CatholicUniversityofSacredHeart,Policlinico A. Gemelli, Rome, Italy 32Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland 33Laboratory of Behavioral Genetics, Brain Mind Institute, EPFL, Lausanne, Switzerland 34Translational Neuromodeling Unit (TNU), Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland 35Bipolar Disorders Program, Institute of Neuroscience, Hospital Clínic Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Barcelona, Catalonia, Spain 36Leiden Institute for Brain and Cogntion/PsychiatricNeuroimaging,Dept.ofPsychiatry,LeidenUniversityMedicalCenter 37Department of Psychology, Institute of Psychiatry, King’s College London, UK 38Parc 2 SanitariSantJoandeDéu,UniversityofBarcelona,CIBERSAM,Barcelona,Spain39Instituteof Clinical Psychology and Psychotherapy, TU Dresden, Dresden, Germany * Convenor for workpackagesubgroups+Correspondingauthor +Addresscorrespondenceto ProfessorGunterSchumann MRCRSocialGeneticDevelopmentalPsychiatryCentre InstituteofPsychiatry,King’sCollegeLondon PO80,16DeCrespignyPark LondonSE58AF UnitedKingdom Tel:+442078485314 Email:[email protected] 3 Abstract There is recognition that biomedical research into the causes of mental disorders and their treatment needs to adopt new approaches to research. Novel biomedical techniqueshaveadvancedourunderstandingofhowthebraindevelopsandisshapedby behaviour and environment. This has led to the advent of stratified medicine, which translates advances in basic research by targeting aetiological mechanisms underlying mentaldisorder.Theresultingincreaseindiagnosticprecisionandtargetedtreatmentsmay provideawindowofopportunitytoaddressthelargepublichealthburden,andindividual sufferingassociatedwithmentaldisorders. While mental health and mental disorders have significant representation in the “health, demographic change and wellbeing” challenge identified in Horizon 2020, the framework programme for research and innovation of the European Commission (2014 2020), and in national funding agencies, clear advice on a potential strategy for mental healthresearchinvestmentisneeded.Thedevelopmentofsuchastrategyissupportedby the ECRfunded “Roadmap for Mental Health Research” (ROAMER) which will provide recommendationsforaEuropeanmentalhealthresearchstrategyintegratingtheareasof biomedicine,psychology,publichealthwellbeing,researchintegrationandstructuring,and stakeholderparticipation. Leading experts on biomedical research on mental disorders have provided an assessmentofthestateoftheartincorepsychopathologicaldomains,includingarousaland stress regulation, affect, cognition social processes, comorbidity and pharmacotherapy, Theyhaveidentifiedmajoradvancesandpromising methodsand pointedout gapsto be addressedinordertoachievethepromiseofastratifiedmedicineformentaldisorders. 4 1 Introduction The worldwide disease burden (DALY) of mental disorders among non communicable diseases is 28% (Prince et al., 2007) and the cost of mental disorders in Europein2010was€523.3billion(Gustavssonetal.,2011).Thisisaseverepublichealth
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