Roshan COOLS Curriculum Vitae PERSONAL DETAILS Name: Prof. dr. Roshan Cools Address: Donders Centre for Cognitive Neuroimagiing, Kapittelweg 29, 6500 HB, Nijmegen Date and place of birth: 10/06/1975, Nijmegen Nationality: Dutch Birth country of parents: Netherlands Email: [email protected]; Website: www.roshancools.com AFFILIATIONS Full Professor of Cognitive Neuropsychiatry Department of Psychiatry, Radboudumc Principle Investigator Motivational and Cognitive Control group, Donders Centre for Cognitive Neuroimaging Member Perception, Action and Control Theme, Donders Institute for Brain, Cognition and Behaviour Member Stress Disorders Theme, Radboudumc Member Advisory Council for Science, Technology and Innovation EDUCATION 2003 Ph.D., Experimental Psychology, Univ Cambridge (10/05/2003). Title thesis: ‘Parkinson’s disease as a model of dopamine-dependent fronto-striatal cognitive dysfunction’ 2000 M.Phil, Experimental psychology, Univ Cambridge UK (01/09/1999) 1998 M.A., Experimental psychology and neuropsychology Cum Laude (28/08/1998), Univ Groningen WORK EXPERIENCE AND POSITIONS 2014-present Member of the Advisory Council of Science, Technology and Innovation 2011-present Full Professor of Cognitive Neuropsychiatry, Department of Psychiatry, Radboud University Medical Center, 2009-2011 Associate Professor, Department of Psychiatry, Radboud University Medical Center 2007-2009 Assistant Professor (tenured), Department of Psychiatry, Radboud University Medical Center 2007-present Principal Investigator, Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour Roshan COOLS Curriculum Vitae 2006-2007 Royal Society University Research fellow, University of Cambridge 2003-2005 Postdoctoral fellow, Helen Wills Neuroscience Institute, University of California, Berkeley 2002-20016 Royal Society Dorothy Hodgkin research fellow, University of Cambridge Maternity leave April 2012-August 2012 Oct 2015 – February 2016 HONOURS AND RECOGNITIONS 2019 Member of F1000 2018 Elected Member of the Royal Netherlands Academy of Arts and Sciences (KNAW) Members the KNAW represent the full spectrum of scientific and scholarly endeavor and are selected on the basis of their scientific achievements. Members are appointed for life. 2018 Elected Member of the International Neuropsychological Society (INS) Promotes the international and interdisciplinary study of brain-behavioral relationships throughout the lifespan. 2018 Elected Member of the Academia Europaea The Academia Europaea is a European, non-governmental association academy of scientists and scholars who collectively aim to promote learning, education and research (2000 members, 40 Novel laureates). 2013 Fellow, Association for Psychological Science, UK Fellow status is awarded to APS members who have made sustained outstanding contributions to the science of psychology SCIENTIFIC AWARDS AND PERSONAL FELLOWSHIPS 2017 KNAW Ammodo Award in Social Sciences This mid-career award is granted to individuals with outstanding scientific achievements and to support fundamental research 2015 Vici award from the Netherlands Organization for Scientific Research 2012 James McDonnell Scholar Award 2012 Young Investigator Award of the Cognitive Neuroscience Society 2011 Radboud Science Award for best research at Radboud University 2008 Vidi award from the Netherlands Organization for Scientific Research 2006 Royal Society University Research Fellowship, University of Cambridge UK 2002 Royal Society Dorothy Hodgkin Research Fellowship, University of Cambridge UK 2002 Junior Research Fellowship, St John’s College, Cambridge UK 2002 Human Frontiers Longterm Fellowship (declined) 1999 CD Marsden Studentship, Parkinson’s Disease Society of the UK 1999 Mary Ann Eward Studentship, Newnham College, Cambridge UK 1998 Cambridge European Trust Award, UK 1998 Dutch-British Partnership Award, Cambridge UK Roshan COOLS Curriculum Vitae 1998 MSc degree with Cum Laude PERSONAL STATEMENT Willpower. Scholars from a variety of disciplines have been fascinated by this phenomenon for centuries. It is considered to be one of the most distinct as well as most vulnerable aspects of the human mind. In psychology, it is a phenomenon intimately linked with functions such as cognitive control, motivation and choice. Cognitive control is an ill-defined term, but generally refers to the ability to direct our behaviour at our goals. A longstanding question concerns the driving force behind such goal-directed behaviour. What are the mechanisms by which we motivate ourselves to act in accordance with our goals? I have approached this question from a unique angle, studying effects of key brain chemicals, such as dopamine and serotonin. CONTRIBUTION TO SCIENCE I am in expert in chemical neuromodulation of human cognition and have approached timely questions about motivation, choice and cognitive control from a unique neuromodulatory angle, combining the most advanced, cutting-edge techniques for manipulating and quantifying the effects of dopamine and serotonin. Key specific breakthroughs include the discoveries that (i) dopamine can both enhance and undermine human cognitive control (compare dopamine’s role in the effects of smart drugs with that in drug addiction) (Cools and D’Esposito, 2011), (ii) effects of dopaminergic drugs depend on baseline levels of dopamine, improving cognition in low-dopamine subjects, but detrimentally overdosing cognition in high-dopamine subjects (Cools et al., 2009), (iii) individual differences in working memory capacity reflect individual variation in dopamine synthesis capacity (Cools et al., 2008), (iv) effects of reward motivation (the promise of reward) on human cognition depend on baseline dopamine levels, with low-dopamine subjects benefiting, but high-dopamine subjects being impaired by the promise of reward (Aarts et al., 2014), (v) effects of dopaminergic drugs depend on the target brain region, with striatal and prefrontal dopamine having opponent effects on the flexibility/stability tradeoff (Cools et al., 2007), (vi) smart drugs like methylphenidate improve cognitive stability but impair cognitive flexibility (Fallon et al., 2017) and (vii) dopaminergic drugs modulate cognitive control by changing the willingness rather than ability to exert control (Frobose et al., 2018). In my earliest contribution, a publication in Cerebral Cortex in 2001, I put forward the ‘dopamine overdose hypothesis’ to account for the contrasting cognitive effects of dopaminergic medication in patients with Parkinson’s disease. I discovered that the dopaminergic medication doses that are necessary to remediate the motor deficits of Parkinson’s disease detrimentally overdose dopamine levels in relatively intact brain regions, such as the ventral striatum and prefrontal cortex, impairing key cognitive functions. Such discoveries, in particular on the behavioural role of the major ascending neuromodulators dopamine and serotonin, have provided important empirical foundations for current theoretical thinking and computational modelling work about dopamine and serotonin. In my so far best cited paper (2011 Biological Psychiatry, 854 cites), I summarize key principles of dopamine function derived from this empirical work, including the baseline-dependency and neurochemical Roshan COOLS Curriculum Vitae opponency principles. SUPERVISION Academic staff PhDs Promotor Ongoing 10 Completed 15 Total 25 Postdoc’s Ongoing 6 Completed 13 Total 19 Associate PIs Ongoing 1 Cools has personally mentored 25 PhD students (15 completed, 10 current), and 19 post-doctoral Commented [RC1]: Payam Piray Esther Aarts fellows (including 6 current). She also has 1 associated principal investigator associated with her group Martine van Schouwenburg (Esther Aarts). In addition, she has mentored 23 research master students towards completing their Marieke van der Schaaf Katinka von Borries major internship (with project durations ranging from 6 to 12 months). Martine Hoogman Mirjam Bloemendaal Lieneke Janssen PhD Students (Completed) Dirk Geurts Jasper Winkel Daniel von Rhein Name Supervision Year of Title of thesis Current Mieke van Holstein team completion position Verena Ly Monique Timmer Jennifer Swart 1. Esther Aarts Ardi Roelofs 2010 Resisting temptation. The Assistant Lieke Hofmans Monja Froboese Roshan Cools role of the anterior professor, Ruben van den Bosch cingulate cortex in Radboud Lieke van Lieshout Marpessa Rietbergen adjusting cognitive University, Sofie Brolsma control Nijmegen Annelies van Nuland 2. Martine van Roshan Cools 2012 Frontostriatal Postdoctoral Jorryt Schouwenburg Hanneke den mechanisms of fellow, Patricia Romero-Verdugo Ouden attentional control University of Danae Papadopetraki Amsterdam 3. Martine Barbara Franke 2013 Imaging the effects of Assistant Hoogman Jan Buitelaar ADHD risk genes professor, Roshan Cools Radboudumc Nijmegen 4. Katinka van Robbert Jan 2014 Carrots and sticks. A Clinical Borries Verkes neurobehavioral psychologist, Roshan Cools investigation of affective Germany outcome processing in psychopathy 5. Daniel von Jan Buitelaar 2015 Neural mechanisms of Research Rhein Roshan Cools reward processing in scientist, attention- Radboudumc deficit/hyperactivity Nijmegen Roshan COOLS Curriculum Vitae disorder 6. Marieke van Roshan Cools 2015 Dopaminergic Postdoctoral der Schaaf modulation of reward fellow, and punishment learning Radboudumc Nijmegen 7. Verena Ly Roshan Cools 2016 Affective biasing of Assistant Karin Roelofs instrumental action. How Professor, emotion