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DRUGS TO BE AVOIDED BY CONGENITAL LONG QT PATIENTS

CredibleMeds® has reviewed all available evidence and has placed the following drugs in designated risk categories for their risk of causing torsades de pointes (TdP): Known Risk of TdP (KR), Possible Risk of TdP (PR), Conditional Risk of TdP (CR) or Special Risk (SR). The full description of these categories can be found on the CredibleMeds website. We recommend that patients with Congenital Long QT Syndrome avoid use of these medicines if at all possible or take them under close medical observation.

Generic Name Brand Name Generic Name Brand Name Generic Name Brand Name Albuterol (salbutamol) Bepridil (KR) Vascor Degarelix (PR) Firmagon Proventil and others (SR) Bortezomib (PR) Velcade and others Delamanid (PR) Deltyba Alfuzosin (PR) Uroxatral Bosutinib (PR) Bosulif (PR) Pertofrane and others (CR) Symmetrel and others (PR) Butrans and others Deutetrabenazine Austedo Amiodarone (KR) Cordarone and others (PR) Cabozantinib (PR) Cometriq (CR) Solian and others Dexmedetomidine Capecitabine (PR) Xeloda Precedex and others (PR) Elavil (Discontinued (CR) Ceritinib (PR) Zykadia 6/13) and others Dexmethylphenidate Focalin and others Aquachloral and (SR) (CR) Adderal-XR and others others (Amfetamine) (SR) Dextroamphetamine Dexedrine and others Chloroquine (KR) Aralen (Dexamfetamine) (SR) Amphotericin B (CR) Fungilin and others (KR) Thorazine and others Anagrelide (KR) Agrylin and others Benadryl and others Cilostazol (KR) Pletal (CR) (PR) Apokyn and others Ciprofloxacin (KR) Cipro and others Disopyramide (KR) Norpace Arformoterol (SR) Brovana (KR) Propulsid Dobutamine (SR) Dobutrex (PR) Abilify and others Citalopram (KR) Celexa and others Dofetilide (KR) Tikosyn Arsenic trioxide (KR) Trisenox Clarithromycin (KR) Biaxin and others (PR) Anzemet Artenimol+piperaquine Eurartesim (KR) Motilium and others (PR) (PR) Anafranil Donepezil (KR) Aricept (PR) Saphris and others (PR) Clozaril and others (SR) Intropine (KR) Hismanal (KR) Cocaine (CR) Sinequan and others Atazanavir (CR) Reyataz and others Crizotinib (PR) Xalkori Dronedarone (KR) Multaq Atomoxetine (PR) Strattera (cyamepromazine) Tercian (KR) Inapsine and others Azithromycin (KR) Zithromax and others (PR) Droxidopa (SR) Northera Bedaquiline (PR) Sirturo Dabrafenib (PR) Tafinlar (PR) Sustiva and others Bendamustine (PR) Treanda and others Dasatinib (PR) Sprycel Eliglustat (PR) Cerdelga Bendroflumethiazide or Aprinox bendrofluazide (CR) Ephedrine (SR) Rynatuss and others

If list is printed, check website at www.crediblemeds.org • Please see Disclaimer below • List continued over Generic Name Brand Name Generic Name Brand Name Generic Name Brand Name Epinephrine (adrenaline) Hydrochlorothiazide (CR) Apo-Hydro and others Lithium (PR) Eskalith and others Primatene and others (SR) - ER (PR) Hysinglaâ„¢ ER and others Imodium and many other OTC Loperamide (CR) Epirubicin (PR) Ellence and others and Rx brands Hydroxychloroquine (CR) Plaquenil and others Eribulin mesylate (PR) Halaven (PR) Bunil and others (CR) Atarax and others Erythromycin (KR) E.E.S. and others (KR) Serentil (KR) None Escitalopram (KR) Cipralex and others Metaproterenol (orciprenaline) Ibutilide (KR) Corvert Metaprel and others (SR) Esomeprazole (CR) Nexium and others (PR) Fanapt and others (KR) Dolophine and others Ezogabine (Retigabine) Potiga and others (melipramine) (PR) Tofranil Methamphetamine (PR) Desoxyn and others (Metamfetamine) (SR) Famotidine (PR) Pepcid and others Arcapta Neohaler (US) and Indacaterol (SR) Methylphenidate (SR) Ritalin and others Felbamate (PR) Felbatol others (CR) Reglan and others (SR) Pondimin and others Indapamide (CR) Lozol and others Metronidazole (CR) Flagyl and many others Fingolimod (PR) Gilenya Isoproterenol (SR) Medihaler-Iso and others Midodrine (SR) ProAmatine and others Flecainide (KR) Tambocor and others Isradipine (PR) Dynacirc Midostaurin (PR) Rydapt Fluconazole (KR) Diflucan and others Itraconazole (CR) Sporanox and others Mifepristone (PR) Korlym and others (CR) Prozac and others Ivabradine (CR) Procoralan and others Mirabegron (PR) Myrbetriq (PR) Depixol and others (PR) Sufrexal (PR) Remeron Fluvoxamine (CR) Faverin and others Ketoconazole (CR) Nizoral and others Moexipril/HCTZ (PR) Uniretic and others Formoterol (SR) Foradil and others Lansoprazole (CR) Prevacid Moxifloxacin (KR) Avelox and others (frusemide) Lapatinib (PR) Tykerb and others Lasix and others (CR) Necitumumab (PR) Portrazza Lenvatinib (PR) Lenvima (CR) Reminyl and others Nelfinavir (CR) Viracept Leuprolide (PR) Lupron and others Garenoxacin (CR) Geninax (PR) Cardene Levalbuterol (levsalbutamol) Xopenex and others Gatifloxacin (KR) Tequin (SR) Nilotinib (PR) Tasigna Gemifloxacin (PR) Factive Levofloxacin (KR) Levaquin and others Norepinephrine (SR) Levophed (PR) Kytril and others (KR) Nosinan and others Norfloxacin (PR) Noroxin and others Grepafloxacin (KR) Raxar Levomethadyl acetate (KR) Orlaam (PR) Pamelor and others Halofantrine (KR) Halfan Levosulpiride (KR) Lesuride and others Nusinersen (PR) Spinraza Haldol (US & UK) and Lisdexamfetamine (SR) Vyvanse Ofloxacin (PR) Floxin (KR) others

If list is printed, check website at www.crediblemeds.org • Please see Disclaimer below • List continued over Generic Name Brand Name Generic Name Brand Name Generic Name Brand Name (CR) Zyprexa and others (KR) Diprivan and others Telaprevir (CR) Incivo and others Olodaterol (SR) Striverdi Respimat (PR) Dominal and others Telavancin (PR) Vibativ Omeprazole (CR) Losec and others Pseudoephedrine (SR) PediaCare and others Telithromycin (PR) Ketek (KR) Zofran and others (CR) Seroquel Terbutaline (SR) Brethine and others Osimertinib (PR) Tagrisso Quinidine (KR) Quinaglute and others Terfenadine (KR) Seldane Oxaliplatin (KR) Eloxatin Quinine sulfate (CR) Qualaquin Terlipressin (KR) Teripress and others Oxytocin (PR) Pitocin and others Ranolazine (CR) Ranexa and others Terodiline (KR) Micturin and others (PR) Invega and others Ribociclib (PR) Kisqali Tetrabenazine (PR) Nitoman and others (PR) Aloxi Rilpivirine (PR) Edurant and others (KR) Mellaril and others Panobinostat (PR) Farydak (PR) Risperdal Tiapride (PR) Tiapridal and others Pantoprazole (CR) Protonix and others Ritodrine (SR) Yutopar Tipiracil and Trifluridine (PR) Lonsurf Papaverine HCl (Intra- Ritonavir (CR) Norvir Tizanidine (PR) Zanaflex and others none coronary) (KR) Romidepsin (PR) Istodax Tolterodine (PR) Detrol and others Paroxetine (CR) Paxil and others Roxithromycin (KR) Rulide and others Toremifene (PR) Fareston Pasireotide (PR) Signifor Salmeterol (SR) Serevent and others torsemide (CR) Demadex and others Pazopanib (PR) Votrient Saquinavir (PR) Invirase(combo) Desyrel (discontinued 6/13) (CR) Pentamidine (KR) Pentam and others (PR) Serdolect and others Perflutren lipid Trimethoprim- Definity and others Sertraline (CR) Zoloft and others Septra and others microspheres (PR) Sulfamethoxazole (SR) (KR) Ultane and others (PR) Trilafon and others (PR) Surmontil and others Sibutramine (SR) Meridia Phentermine (SR) Adipex P and others Tropisetron (PR) Navoban and others Solifenacin (CR) Vesicare Phenylephrine (SR) Neosynephrine Valbenazine (PR) Ingrezza Sorafenib (PR) Nexavar Phenylpropanolamine (SR) Acutrim and others Vandetanib (KR) Caprelsa Sotalol (KR) Betapace and others Pilsicainide (PR) Sunrythm Vardenafil (PR) Levitra Sparfloxacin (KR) Zagam (PR) Nuplazid Vemurafenib (PR) Zelboraf Sulpiride (KR) Dogmatil and others (KR) Orap Venlafaxine (PR) Effexor and others Sultopride (KR) Barnetil and others (PR) Dipiperon (E.U) and others Vilanterol/fluticasone furoate Breo Ellipta Sunitinib (PR) Sutent (SR) Piperacillin/Tazobactam Tazosyn and Zosyn (CR) Tacrolimus (PR) Prograf and others Voriconazole (CR) VFend Posaconazole (CR) Noxafil and others Nolvadex(discontinued Vorinostat (PR) Zolinza (PR) 6/13) and others Probucol (KR) Lorelco (CR) Geodon and others Procainamide (KR) Pronestyl and others (PR) Losizopilon and others Note: Medicines (PR) on this listPhenergan are reviewed on an ongoing basis to assure that the available evidence supports their continued placement on this list. The list changes regularly and we recommend checking the website at crediblemeds.org for the most up-to-date information. There may be many additional brand names that are not listed on this form.

Disclaimer and Waiver: The information presented is intended solely for the purpose of providing general information about health-related matters. It is not intended for any other purpose, including but not limited to medical advice and/or treatment, nor is it intended to substitute for the users relationships with their own health care providers. To that extent, by use of this website and the information it contains, the user affirms the understanding of the purpose and releases AZCERT, Inc. from any claims arising out of his/her use of the website and its lists. The absence of drugs from these lists should not be considered an indication that they are free of risk of QT prolongation or torsades de pointes. Many medicines have not been tested for this risk in patients, especially those with congenital long QT syndrome. Generated: August 24, 2017. List last revised: August 23, 2017