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Title (En) Noribogaine in the Treatment of Pain and Drug Addiction

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Title (En) Noribogaine in the Treatment of Pain and Drug Addiction Title (en) Noribogaine in the treatment of pain and drug addiction Title (de) Noribogain zur Behandlung von Schmerzen und Drogenabhängigkeit Title (fr) Noribogain utilisée pour le traitement de la douleur et de la toxicomanie Publication EP 2338494 A1 20110629 (EN) Application EP 10180121 A 19980903 Priority • EP 03075683 A 19980903 • EP 98944698 A 19980903 • US 5792197 P 19970904 Abstract (en) The present invention is directed to methods of treating patients for pain by administering noribogaine. Noribogaine may also be used to treat patients for the symptoms associated with withdrawal from drug dependency. In the latter case, the noribogaine treatment should be supplemented with the administration of an opioid antagonist such as naloxone. IPC 8 full level A61K 31/55 (2006.01); A61K 31/485 (2006.01); A61P 25/04 (2006.01) CPC (source: EP) A61K 31/485 (2013.01); A61K 31/55 (2013.01); A61P 25/04 (2018.01); A61P 25/22 (2018.01); A61P 25/30 (2018.01); A61P 25/36 (2018.01) C-Set (source: EP) 1. A61K 31/485 + A61K 2300/00 2. A61K 31/55 + A61K 2300/00 Citation (applicant) • US 4499096 A 19850212 - LOTSOF HOWARD S [US] • US 4587243 A 19860506 - LOTSOF HOWARD S [US] • US 4857523 A 19890815 - LOTSOF HOWARD S [US] • US 5026697 A 19910625 - LOTSOF HOWARD S [US] • US 5152994 A 19921006 - LOTSOF HOWARD S [US] • US 4806341 A 19890221 - CHIEN YIE W [US], et al • US 5149538 A 19920922 - GRANGER COLIN D [US], et al • US 4626539 A 19861202 - AUNGST BRUCE [US], et al • J. PHARM. AND EXP. THER., vol. 120, no. 1, 1957, pages 20 - 25 • "Potentiation Action of Ibogaine on Morphine Analgesia", EXPERIENTIAL, vol. 12, 1956, pages 323 - 24 • "Neuropharmacological Studies of Ibogaine: An Indole Alkaloid with Central Stimulant Properties", ANN. OFN.Y. ACAD. SCI., vol. 66, 1957, pages 765 - 76 • "An Analysis of the Cardiovascular Action of Ibogaine HCI", ARCH. INT. PHARMACODYN., vol. 110, 1957, pages 92 - 102 • KOSTOWSKI ET AL.: "The Effects of Some Hallucinogens on Aggressiveness of Mice and Rats", PHARMACOLOGY, vol. 7, 1972, pages 259 - 63 • ZETLER ET AL.: "Cerebral Pharmacokinetics of Tremor-Producing Harmala and Iboga Alkaloids", PHARMACOLOGY, vol. 7, no. 4, 1972, pages 237 - 248 • WHITAKER: "High Affinity 3H-Serotonin Binding to Caudate: Inhibition by Hallucinogenic and Serotonergic Drugs", PSYCHOPHARMACOLOGY, vol. 59, 1978, pages 1 - 5 • "Selective Labeling Of Serotonin Receptors by d-(3H)Lysergic Acid Diethylamide in Calf Caudate", PROC. NATL. ACAD. SCI., U.S.A., vol. 75, no. 12, 1978, pages 5783 - 87 • SLOVITER ET AL.: "A Common Mechanism of Lysergic Acid, Indolealkylamine and Phenethylamine Hallucinogens: Serotonergic Mediation of Behavioral Effects in Rats", J. PHARM. EXP. THER., vol. 214, no. 2, 1980, pages 231 - 38 • DZOLJIC ET AL.: "Effect of Ibogaine on Naloxone-Precipitated Withdrawal Syndrome in Chronic Morphine Dependent Rats", ARCH. INT. PHARMACODYN., vol. 294, 1988, pages 64 - 70 • HUFFINAN ET AL., J. ORG. CHEM., vol. 50, 1985, pages 1460 • A. OSLO: "Remington's Pharmaceutical Sciences,16th ed.,", 1980 Citation (search report) • [A] US 5591738 A 19970107 - LOTSOF HOWARD S [US] • [A] US 5426112 A 19950620 - ZAGON IAN S [US], et al • [A] US 3715361 A 19730206 - EPSTEIN J, et al • [A] GB 841697 A 19600720 - CIBA LTD • [A] WO 9603127 A1 19960208 - NDA INT INC [US] • [Y] A.A.BAGAL ET AL.: "Modulation of morphine-induced antinociception by ibogaine and noribogaine", BRAIN RESEARCH, vol. 741, no. 1-2, 1996, pages 258 - 262, XP002094531 • [YP] DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 5 January 1998 (1998-01-05), PABLO J P ET AL: "Noribogaine stimulates naloxone-sensitive [35S]GTPgammaS binding.", XP002600747, Database accession no. NLM9592058 Cited by EP2788003A4; US9394294B2; US9617274B1; US9403817B2; US9308272B2; US9783535B2; US9358237B2; US9469649B2 Designated contracting state (EPC) AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE DOCDB simple family (publication) WO 9911250 A2 19990311; WO 9911250 A3 19990805; AT 265213 T 20040515; AT 510542 T 20110615; AU 754088 B2 20021107; AU 9217498 A 19990322; CA 2302754 A1 19990311; CA 2302754 C 20111108; DE 69823520 D1 20040603; DE 69823520 T2 20050512; EP 1009407 A2 20000621; EP 1009407 B1 20040428; EP 1327447 A1 20030716; EP 1327447 B1 20110525; EP 2246058 A1 20101103; EP 2338494 A1 20110629; EP 2338494 B1 20130710; ES 2224430 T3 20050301; ES 2395268 T3 20130211; ES 2435722 T3 20131223; IL 134796 A 20081126; IL 134796 D0 20010430; US 2007185085 A1 20070809; US 2010311722 A1 20101209; US 2010311723 A1 20101209; US 2010311724 A1 20101209; US 2010311725 A1 20101209; US 2012083485 A1 20120405; US 7754710 B2 20100713; US 8178524 B2 20120515 DOCDB simple family (application) US 9818284 W 19980903; AT 03075683 T 19980903; AT 98944698 T 19980903; AU 9217498 A 19980903; CA 2302754 A 19980903; DE 69823520 T 19980903; EP 03075683 A 19980903; EP 10170898 A 19980903; EP 10180121 A 19980903; EP 98944698 A 19980903; ES 03075683 T 19980903; ES 10180121 T 19980903; ES 98944698 T 19980903; IL 13479600 A 20000229; IL 13479698 A 19980903; US 201113315127 A 20111208; US 78434307 A 20070406; US 79624110 A 20100608; US 79624710 A 20100608; US 79624910 A 20100608; US 81590810 A 20100615.
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