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Misuse of Drugs Act (MEI 2013).Fm
LAWS OF BRUNEI CHAPTER 27 MISUSE OF DRUGS 7 of 1978 9 of 1979 1984 Edition, Chapter 27 Amended by 10 of 1982 S 27/1982 S 20/1984 S 8/1987 S 36/1987 S 20/1989 S 24/1991 S 20/1992 S 28/1994 S 42/1998 S 60/1999 2001 Edition, Chapter 27 Amended by S 7/2002 S 59/2007 S 5/2008 S 12/2010 S 12/2012 REVISED EDITION 2013 B.L.R.O. 2/2013 LAWS OF BRUNEI Misuse of Drugs CAP. 27 1 LAWS OF BRUNEI REVISED EDITION 2013 CHAPTER 27 MISUSE OF DRUGS ARRANGEMENT OF SECTIONS Section PART I PRELIMINARY 1. Citation. 2. Interpretation. 2A. Appointment of Director and other officers of Bureau. 2B. Public servants. 2C. Powers of investigations of Bureau. 2D. Use of weapons. PART II OFFENCES INVOLVING CONTROLLED DRUGS 3. Trafficking in controlled drug. 3A. Possession for purpose of trafficking. 4. Manufacture of controlled drug. 5. Importation and exportation of controlled drug. B.L.R.O. 2/2013 LAWS OF BRUNEI 2 CAP. 27 Misuse of Drugs 6. Possession and consumption of controlled drug. 6A. Consumption of controlled drug outside Brunei Darussalam by permanent resident. 6B. Place of consumption need not be stated or proven. 7. Possession of pipes, utensils etc. 8. Cultivation of cannabis, opium and coca plants. 8A. Manufacture, supply, possession, import or export of equipment, materials or substances useful for manufacture of controlled drugs. 8B. Regulations and controlled substances. 9. Responsibilities of owners and tenants etc. 10. Abetments and attempts punishable as offences. 11. -
Tramadol (Ultram)
TRAMADOL (ULTRAM) Tramadol is FDA approved for the treatment of musculoskeletal pain. Studies have shown it is useful in treating the pain associated with diabetic neuropathy and other pain conditions. Tramadol comes in 50 mg tablets. The maximum dose is two tablets four times per day unless your kidney function is below normal or you are over 75 years old, in which case the maximum dose is two tablets three times per day. The main side effects of Tramadol are drowsiness, sedation, and stomach upset, all of which are minimized by slowly raising the dose. About 5% of patients have stomach upset at any dose of Tramadol and cannot take the medicine. Other risks include seizures (occur in less than 1/100,000 and are more likely if you have seizures) and possibly abuse (relevant if you have abused drugs in the past). Tramadol should be started at a low dose and raise the dose slowly toward the maximum dose. Start with one tablet at bedtime. After 3 - 7 days, increase to one tablet twice daily (morning and bedtime). After an additional 3 - 7 days, increase to one tablet three times per day (morning, noon, and bedtime). After an additional 3 - 7 days, increase to one tablet four times per day (1 tablet with each meal and 1 at bedtime). At that point, the dose may be increased or adjusted depending on how you are doing. To increase further, you will: Add a second tablet at bedtime (one tablet three times per day and two tablets at bedtime). After 3 - 7 days, add a second tablet to another dose (one tablet twice per day and two tablets twice per day). -
Effects of Prophylactic Ketamine and Pethidine to Control Postanesthetic Shivering: a Comparative Study
Biomedical Research and Therapy, 5(12):2898-2903 Original Research Effects of prophylactic ketamine and pethidine to control postanesthetic shivering: A comparative study Masoum Khoshfetrat1, Ali Rosom Jalali2, Gholamreza Komeili3, Aliakbar Keykha4;∗ ABSTRACT Background: Shivering is an undesirable complication following general anesthesia and spinal anesthesia, whose early control can reduce postoperative metabolic and respiratory complications. Therefore, this study aims to compare the effects of prophylactic injection of ketamine and pethi- dine on postoperative shivering.Methods: This double-blind clinical trial was performed on 105 patients with short-term orthopedic and ENT surgery. The patients were randomly divided into three groups; 20 minutes before the end of the surgery, 0.4 mg/kg of pethidine was injected to the first group, 0.5 mg/kg of ketamine was injected to the second group, and normal saline was injected to the third group. After the surgery, the tympanic membrane temperature was measured at 0, 10, 20, and 30 minutes. The shivering was also measured by a four-point grading from zero (no shiv- ering) to four (severe shivering). Data were analyzed by one-way ANOVA, Kruskal Wallis, Chi-square 1Doctor of Medicine (MD), Fellow of and Pearson correlation. Results: The mean age of patients was 35.811.45 years in the ketamine Critical Care Medicine (FCCM), group, 34.811.64 years in the normal saline group, and 33.1110.5 years in the pethidine group. Department of Anesthesiology and The one-way ANOVA showed no significant difference in the mean age between the three groups Critical Care, Khatam-Al-Anbiya (P=0.645). -
Current Awareness in Clinical Toxicology Editors: Damian Ballam Msc and Allister Vale MD
Current Awareness in Clinical Toxicology Editors: Damian Ballam MSc and Allister Vale MD February 2016 CONTENTS General Toxicology 9 Metals 38 Management 21 Pesticides 41 Drugs 23 Chemical Warfare 42 Chemical Incidents & 32 Plants 43 Pollution Chemicals 33 Animals 43 CURRENT AWARENESS PAPERS OF THE MONTH How toxic is ibogaine? Litjens RPW, Brunt TM. Clin Toxicol 2016; online early: doi: 10.3109/15563650.2016.1138226: Context Ibogaine is a psychoactive indole alkaloid found in the African rainforest shrub Tabernanthe Iboga. It is unlicensed but used in the treatment of drug and alcohol addiction. However, reports of ibogaine's toxicity are cause for concern. Objectives To review ibogaine's pharmacokinetics and pharmacodynamics, mechanisms of action and reported toxicity. Methods A search of the literature available on PubMed was done, using the keywords "ibogaine" and "noribogaine". The search criteria were "mechanism of action", "pharmacokinetics", "pharmacodynamics", "neurotransmitters", "toxicology", "toxicity", "cardiac", "neurotoxic", "human data", "animal data", "addiction", "anti-addictive", "withdrawal", "death" and "fatalities". The searches identified 382 unique references, of which 156 involved human data. Further research revealed 14 detailed toxicological case reports. Current Awareness in Clinical Toxicology is produced monthly for the American Academy of Clinical Toxicology by the Birmingham Unit of the UK National Poisons Information Service, with contributions from the Cardiff, Edinburgh, and Newcastle Units. The NPIS is commissioned by Public Health England Current Awareness in Clinical Toxicology Editors: Damian Ballam MSc and Allister Vale MD February 2016 Current Awareness in Clinical Toxicology is produced monthly for the American Academy of Clinical Toxicology by the Birmingham Unit of the UK National Poisons Information Service, with contributions from the Cardiff, Edinburgh, and Newcastle Units. -
“STOP” and “GO” Pathways for the Treatment of Alcohol Use Disorders
UCSF UC San Francisco Previously Published Works Title Targeting the intracellular signaling "STOP" and "GO" pathways for the treatment of alcohol use disorders. Permalink https://escholarship.org/uc/item/6hd3x2cv Journal Psychopharmacology, 235(6) ISSN 0033-3158 Authors Ron, Dorit Berger, Anthony Publication Date 2018-06-01 DOI 10.1007/s00213-018-4882-z Peer reviewed eScholarship.org Powered by the California Digital Library University of California Psychopharmacology (2018) 235:1727–1743 https://doi.org/10.1007/s00213-018-4882-z REVIEW Targeting the intracellular signaling “STOP” and “GO” pathways for the treatment of alcohol use disorders Dorit Ron1 & Anthony Berger1 Received: 18 January 2018 /Accepted: 12 March 2018 /Published online: 14 April 2018 # The Author(s) 2018 Abstract In recent years, research has identified the molecular and neural substrates underlying the transition of moderate “social” con- sumption of alcohol to the characteristic alcohol use disorder (AUD) phenotypes including excessive and compulsive alcohol use which we define in the review as the GO signaling pathways. In addition, growing evidence points to the existence of molecular mechanisms that keep alcohol consumption in check and that confer resilience for the development of AUD which we define herein as the STOP signaling pathways. In this review, we focus on examples of the GO and the STOP intracellular signaling pathways and discuss our current knowledge of how manipulations of these pathways may be used for the treatment of AUD. Keywords Alcohol . Addiction . Signaling . Translation . Medication Development . Fyn . mTOR . BDNF . GDNF Introduction medications such as naltrexone, acamprosate, and disulfiram not only are beneficial but also suffer from efficacy and com- Alcohol use disorder (AUD) is a serious worldwide health prob- pliance issues (Wackernah et al. -
Quantitative Drug Test Menu Section 2
1 Guthrie Square, Sayre, PA 18840 Bill To: Client GMG Toxicology Laboratory Requisition Toll Free Phone (844) 617-4719 Insurance Request Date: _____/______/______ Medical Director: Hani Hojjati, MD Fax (570) 887-4729 Patient PATIENT INFORMATION (PLEASE PRINT IN BLACK INK) INSURANCE BILLING INFORMATION (PLEASE PRINT IN BLACK INK) Pt Last Name First M I PRIMARY Medicare Medicaid Other Ins. Self Spouse Child __ Subscriber Last Name First M Address Birth Date Sex M F Beneficiary/Member # Group # City Pt. SS# or MRN Claims Name and Address City ST ZIP ST ZIP Home Phone (Attach a copy of the patient's insurance card and information) SECONDARY Medicare Medicaid Other Ins. Self Spouse Child Employer Work Phone Subscriber Last Name First M Work Address City ST ZIP Beneficiary/Member # Group # __ CLIENT INFORMATION - REFERRING PHYSICIAN Claims Name and Address City ST ZIP Client Address: (Atttach a copy of the patient's insurance card and information) COLLECTION / REPORTING INFORMATION Copy to: FAX Results to __ CALL Results to Phone: Fax: Date Collected: Time Collected: AM PM Specimen Type: Urine Saliva Other ___________________ Physician Signature (legible - No Stamp) For Lab Use Only (Required for Medicare & Medicaid patient orders) Signed ABN Obtained Place Lab Label Here Contact Laboratory Medical Director (570-887-4719) with questions concerning medical necessity PHYSICIAN When ordering tests, the physician is required to make an independent medical necessity decision with regard to each test thelaboratory will bill. The physician also understands he or she is required NOTICE to (1) submit ICD-10 diagnosis supported in the patient's medical record as documentation of the medical necessity or (2) explain and have the patient sign an ABN. -
Chapter 1—— IBOGAINE: a REVIEW
——Chapter 1—— IBOGAINE: A REVIEW Kenneth R. Alper Departments of Psychiatry and Neurology New York University School of Medicine New York, NY 10016 I. Introduction, Chemical Properties, and Historical Time Line .................................... A. Introduction............................................................................................................ B. Chemical Structure and Properties ........................................................................ C. Historical Time Line.............................................................................................. II. Mechanisms of Action ................................................................................................. A. Neurotransmitter Activities.................................................................................... B. Discrimination Studies........................................................................................... C. Effects on Neuropeptides....................................................................................... D. Possible Effects on Neuroadaptations Related to Drug Sensitization or Tolerance ........................................................................................................... III. Evidence of Efficacy in Animal Models....................................................................... A. Drug Self-Administration ...................................................................................... B. Acute Opioid Withdrawal..................................................................................... -
CAN YOU TAKE TRAMADOL with NEFOPAM Can You Take Tramadol with Nefopam
CAN YOU TAKE TRAMADOL WITH NEFOPAM can you take tramadol with nefopam tramadol 37 5 vs percocet 5 325 ultram tramadol pictures tramadol hcl tabs 50 mg tramadol 200 mg recreational drugs and heart can tramadol and percocet be mixed hbs robaxin tramadol interaction generic tramadol 319 immediate release how long tramadol stay in your urine does tramadol make you sleepy or awake tramadol acetaminophen\/codeine 120 12mg sol b tracert ex tramadol dosage for adults meloxicam/tramadol/amitriptyline/lidocaine/prilocaine apo tramadol high feeling on hydrocodone tramadol apteka internetowa olmed order tramadol/paracetamol from mexico tramadol quizlet flashcards microbiology tramadol has mu opioid agonist activity director jobs tramadol met ritalin sr strengths hur ta tramadol withdrawal in dogs tramadol te gebruiken bij tramadol dosis cachorros bulldog 2015 100mg tramadol 10mg hydrocodone images 100 tramadol termasuk jenis obat apa acyclovir side how to get rid of a tramadol high 200 ml tramadol withdrawal timeline drug interactions between percocet and tramadol comparison tramadol e morfina presentacion de tres can tramadol be taken with paracetamol indication and action tramadol review article template with photos tramadol codeine allergy rash best price tramadol online tramadol 93 58 dosage for ibuprofen tramadol v oxycodone pill colors can tramadol make you drowsy doll b tracert ex tramadol addiction withdrawal tramadol instant release oxycontin pictures can you drink wine with tramadol i can function tramadol hydrochloride sleepy tramadol cva -
Parkinson's Disease Fact Sheet
Parkinson’s Disease Fact Sheet About Parkinson’s Disease Parkinson’s disease is a progressive, incurable neurological disorder associated with a loss of dopamine-generating cells in the brain. It is primarily associated with progressive loss of motor control, but it results in a complex array of symptoms, including many non-motor symptoms. Parkinson’s impacts an estimated one million people in the United States. Critical Clinical Care Considerations • To avoid serious side effects, Parkinson’s patients need their medications on time, every time — do not skip or postpone doses. • Write down the exact times of day medications are to be administered so that doses are given on the same schedule the patient follows at home. • Do not substitute Parkinson’s medications or stop levodopa therapy abruptly. • Resume medications immediately following procedures, unless vomiting or severely incapacitated. • If an antipsychotic is necessary, use pimavanserin (Nuplazid), quetiapine (Seroquel) or clozapine (Clozaril). • Be alert for symptoms of dysphagia (trouble swallowing) and risk of pneumonia. • Ambulate as soon as medically safe. Patients may require assistance. Common Symptoms of Parkinson’s Disease Motor Non-Motor • Shaking or tremor at rest • Depression • Bradykinesia or freezing (being stuck • Anxiety in place when attempting to walk) • Constipation • Low voice volume or muffled speech • Cognitive decline and dementia • Lack of facial expression • Impulse control disorders • Stiffness or rigidity of the arms, legs • Orthostatic hypotension or -
Pharmacogenetics of Ketamine Metabolism And
Pharmacogenetics of Ketamine Metabolism and Immunopharmacology of Ketamine Yibai Li B.HSc. (Hons) Discipline of Pharmacology, School of Medical Sciences, Faculty of Health Sciences, The University of Adelaide September 2014 A thesis submitted for the Degree of PhD (Medicine) Table of contents TABLE OF CONTENTS .............................................................................................. I LIST OF FIGURES ....................................................................................................IV LIST OF TABLES ......................................................................................................IV ABSTRACT ............................................................................................................... V DECLARATION .......................................................................................................VIII ACKNOWLEDGEMENTS ..........................................................................................IX ABBREVIATIONS .....................................................................................................XI CHAPTER 1. INTRODUCTION .................................................................................. 1 1.1 A historical overview of ketamine ........................................................................................ 1 1.2 Structure and Chemistry ....................................................................................................... 3 1.3 Classical analgesic mechanisms of ketamine ................................................................... -
Quantification of Drugs for Drug-Facilitated Crimes in Human Urine
Quantification of Drugs for Drug-Facilitated Crimes in Human Urine by Liquid Chromatography Tandem Mass Spectrometry Claudio De Nardi1, Anna Morando2, Anna Del Plato2 1Thermo Fisher Scientific, Dreieich, Germany; 2Ospedale “La Colletta”, Arenzano, Italy Overview TABLE 1. Concentrations of calibrators TABLE 3. Concentration range, intercept, slope and correlation factor (R2) Purpose: To implement a liquid chromatography tandem mass spectrometry method for forensic toxicology for the CAL CAL CAL CAL CAL CAL CAL Analyte Units Calibration quantification of drugs for drug-facilitated crimes in human 1 2 3 4 5 6 7 Analyte Intercept Slope R2 urine on a Thermo Scientific™ TSQ Access MAX™ triple stage Range Ketamine mass spectrometer; the method includes ketamine, its Ketamine 5 – 200 ng/mL -0.002 0.004 0.999 metabolites norketamine and dehydronorketamine, Norketamine phencyclidine and γ-butyrolactone (GBL); the method is also Norketamine 5 – 200 ng/mL 0.000 0.003 0.998 Dehydro ng/mL 5 10 20 50 100 200 N/A suitable for the detection of γ-hydroxybutyric acid (GHB) at norketamine Dehydronorketamine 5 – 200 ng/mL -0.001 0.002 0.999 physiological levels. Phencyclidine Phencyclidine 5 – 200 ng/mL 0.000 0.003 0.999 Methods: Following extraction using three volumes of GBL µg/mL 1 2 5 10 20 50 100 GBL 1 – 100 µg/mL -0.001 0.008 0.999 methanol containing 0.1% formic acid, samples were injected onto a Thermo Scientific™ Accela™ 600 HPLC system connected to a TSQ Access MAX triple stage mass Mass Spectrometry Figure 1. Calibration curve forGBL GBL spectrometer using a heated electrospray source. -
Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanismss
Supplemental Material can be found at: /content/suppl/2020/12/18/73.1.202.DC1.html 1521-0081/73/1/202–277$35.00 https://doi.org/10.1124/pharmrev.120.000056 PHARMACOLOGICAL REVIEWS Pharmacol Rev 73:202–277, January 2021 Copyright © 2020 by The Author(s) This is an open access article distributed under the CC BY-NC Attribution 4.0 International license. ASSOCIATE EDITOR: MICHAEL NADER Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanismss Antonio Inserra, Danilo De Gregorio, and Gabriella Gobbi Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University, Montreal, Quebec, Canada Abstract ...................................................................................205 Significance Statement. ..................................................................205 I. Introduction . ..............................................................................205 A. Review Outline ........................................................................205 B. Psychiatric Disorders and the Need for Novel Pharmacotherapies .......................206 C. Psychedelic Compounds as Novel Therapeutics in Psychiatry: Overview and Comparison with Current Available Treatments . .....................................206 D. Classical or Serotonergic Psychedelics versus Nonclassical Psychedelics: Definition ......208 Downloaded from E. Dissociative Anesthetics................................................................209 F. Empathogens-Entactogens . ............................................................209