No.IA-J-11011/301/2018-IA-II(I) Goverment of India Minister of Enviroment,Forest and Climate Change Impact Assessment Division ***

Home , Cyanogen azide, Germanium nitride, Hydroxylammonium sulfate, Hyponitrous acid, Magnesium perchlorate, Methyl isocyanate

Indira Paryavaran Bhavan, Vayu Wing,3rd Floor,Aliganj, Jor Bagh Road,New Delhi-110003 17 Nov 2018

To,

M/s MANBRO POLYMERS LIMITED C-73, Shivaji Park, Punjabi Bagh, Delhi-110026, Bharuch-392110 Gujarat

Tel.No.011-45562525; Email:[email protected]

Sir/Madam,

This has reference to the proposal submitted in the Ministry of Environment, Forest and Climate Change to prescribe the Terms of Reference (TOR) for undertaking detailed EIA study for the purpose of obtaining Environmental Clearance in accordance with the provisions of the EIA Notification, 2006. For this purpose, the proponent had submitted online information in the prescribed format (Form-1 ) along with a Pre-feasibility Report. The details of the proposal are given below:

1. Proposal No.: IA/GJ/IND2/80629/2018

2. Name of the Proposal: M/s. Manbro Polymers Limited

3. Category of the Proposal: Industrial Projects - 2

4. Project/Activity applied for: 5(b) Pesticides industry and pesticide specific intermediates (excluding formulations) 5(f) Synthetic organic chemicals industry (dyes & dye intermediates; bulk

5. Date of submission for TOR: 10 Oct 2018

In this regard, under the provisions of the EIA Notification 2006 as amended, the Standard TOR for the purpose of preparing environment impact assessment report and environment management plan for obtaining prior environment clearance is prescribed with public consultation as follows: STANDARD TERMS OF REFERENCE (TOR) FOR EIA/EMP REPORT FOR PROJECTS/ ACTIVITIES REQUIRING ENVIRONMENT CLEARANCE

5(b): STANDARD TERMS OF REFERENCE FOR CONDUCTING ENVIRONMENT IMPACT ASSESSMENT STUDY FOR PESTICIDES INDUSTRY AND PESTICIDE SPECIFIC INTERMEDIATES (EXCLUDING FORMULATIONS)AND INFORMATION TO BE INCLUDED IN EIA/EMP REPORT

A. STANDARD TERMS OF REFERENCE

1) Executive Summary 2) Introduction i. Details of the EIA Consultant including NABET accreditation ii. Information about the project proponent iii. Importance and benefits of the project 3) Project Description i. Cost of project and time of completion. ii. Products with capacities for the proposed project. iii. If expansion project, details of existing products with capacities and whether adequate land is available for expansion, reference of earlier EC if any. iv. List of raw materials required and their source along with mode of transportation. v. Other chemicals and materials required with quantities and storage capacities vi. Details of Emission, effluents, hazardous waste generation and their management. vii. Requirement of water, power, with source of supply, status of approval, water balance diagram, man-power requirement (regular and contract) viii. Process description along with major equipments and machineries, process flow sheet (quantative) from raw material to products to be provided ix. Hazard identification and details of proposed safety systems. x. Expansion/modernization proposals: a. Copy of all the Environmental Clearance(s) including Amendments thereto obtained for the project from MOEF/SEIAA shall be attached as an Annexure. A certified copy of the latest Monitoring Report of the Regional Office of the Ministry of Environment and Forests as per circular dated 30th May, 2012 on the status of compliance of conditions stipulated in all the existing environmental clearances including Amendments shall be provided. In addition, status of compliance of Consent to Operate for the ongoing Iexisting operation of the project from SPCB shall be attached with the EIA-EMP report. STANDARD TERMS OF REFERENCE (TOR) FOR EIA/EMP REPORT FOR PROJECTS/ACTIVITIES REQUIRING ENVIRONMENT CLEARANCE

b. In case the existing project has not obtained environmental clearance, reasons for not taking EC under the provisions of the EIA Notification 1994 and/or EIA Notification 2006 shall be provided. Copies of Consent to Establish/No Objection Certificate and Consent to Operate (in case of units operating prior to EIA Notification 2006, CTE and CTO of FY 2005-2006) obtained from the SPCB shall be submitted. Further, compliance report to the conditions of consents from the SPCB shall be submitted. 4) Site Details i. Location of the project site covering village, Taluka/Tehsil, District and State, Justification for selecting the site, whether other sites were considered. ii. A toposheet of the study area of radius of 10km and site location on 1:50,000/1:25,000 scale on an A3/A2 sheet. (including all eco-sensitive areas and environmentally sensitive places) iii. Details w.r.t. option analysis for selection of site iv. Co-ordinates (lat-long) of all four corners of the site. v. Google map-Earth downloaded of the project site. vi. Layout maps indicating existing unit as well as proposed unit indicating storage area, plant area, greenbelt area, utilities etc. If located within an Industrial area/Estate/Complex, layout of Industrial Area indicating location of unit within the Industrial area/Estate. vii. Photographs of the proposed and existing (if applicable) plant site. If existing, show photographs of plantation/greenbelt, in particular. viii. Landuse break-up of total land of the project site (identified and acquired), government/ private - agricultural, forest, wasteland, water bodies, settlements, etc shall be included. (not required for industrial area) ix. A list of major industries with name and type within study area (10km radius) shall be incorporated. Land use details of the study area x. Geological features and Geo-hydrological status of the study area shall be included. xi. Details of Drainage of the project upto 5km radius of study area. If the site is within 1 km radius of any major river, peak and lean season river discharge as well as flood occurrence frequency based on peak rainfall data of the past 30 years. Details of Flood Level of the project site and maximum Flood Level of the river shall also be provided. (mega green field projects) xii. Status of acquisition of land. If acquisition is not complete, stage of the acquisition process and expected time of complete possession of the land. xiii. R&R details in respect of land in line with state Government policy 5) Forest and wildlife related issues (if applicable): i. Permission and approval for the use of forest land (forestry clearance), if any, and recommendations of the State Forest Department. (if applicable) STANDARD TERMS OF REFERENCE (TOR) FOR EIA/EMP REPORT FOR PROJECTS/ ACTIVITIES REQUIRING ENVIRONMENT CLEARANCE

ii. Landuse map based on High resolution satellite imagery (GPS) of the proposed site delineating the forestland (in case of projects involving forest land more than 40 ha) iii. Status of Application submitted for obtaining the stage I forestry clearance along with latest status shall be submitted. iv. The projects to be located within 10 km of the National Parks, Sanctuaries, Biosphere Reserves, Migratory Corridors of Wild Animals, the project proponent shall submit the map duly authenticated by Chief Wildlife Warden showing these features vis-à-vis the project location and the recommendations or comments of the Chief Wildlife Warden-thereon v. Wildlife Conservation Plan duly authenticated by the Chief Wildlife Warden of the State Government for conservation of Schedule I fauna, if any exists in the study area vi. Copy of application submitted for clearance under the Wildlife (Protection) Act, 1972, to the Standing Committee of the National Board for Wildlife. 6) Environmental Status i. Determination of atmospheric inversion level at the project site and site-specific micro- meteorological data using temperature, relative humidity, hourly wind speed and direction and rainfall. ii. AAQ data (except monsoon) at 8 locations for PM10, PM2.5, SO2, NOX, CO and other parameters relevant to the project shall be collected. The monitoring stations shall be based CPCB guidelines and take into account the pre-dominant wind direction, population zone and sensitive receptors including reserved forests. iii. Raw data of all AAQ measurement for 12 weeks of all stations as per frequency given in the NAQQM Notification of Nov. 2009 along with - min., max., average and 98% values for each of the AAQ parameters from data of all AAQ stations should be provided as an annexure to the EIA Report. iv. Surface water quality of nearby River (100m upstream and downstream of discharge point) and other surface drains at eight locations as per CPCB/MoEF&CC guidelines. v. Whether the site falls near to polluted stretch of river identified by the CPCB/MoEF&CC, if yes give details. vi. Ground water monitoring at minimum at 8 locations shall be included. vii. Noise levels monitoring at 8 locations within the study area. viii. Soil Characteristic as per CPCB guidelines. ix. Traffic study of the area, type of vehicles, frequency of vehicles for transportation of materials, additional traffic due to proposed project, parking arrangement etc. x. Detailed description of flora and fauna (terrestrial and aquatic) existing in the study area shall be given with special reference to rare, endemic and endangered species. If Schedule- I fauna are found within the study area, a Wildlife Conservation Plan shall be prepared and furnished. xi. Socio-economic status of the study area. STANDARD TERMS OF REFERENCE (TOR) FOR EIA/EMP REPORT FOR PROJECTS/ACTIVITIES REQUIRING ENVIRONMENT CLEARANCE

7) Impact and Environment Management Plan i. Assessment of ground level concentration of pollutants from the stack emission based on site-specific meteorological features. In case the project is located on a hilly terrain, the AQIP Modelling shall be done using inputs of the specific terrain characteristics for determining the potential impacts of the project on the AAQ. Cumulative impact of all sources of emissions (including transportation) on the AAQ of the area shall be assessed. Details of the model used and the input data used for modelling shall also be provided. The air quality contours shall be plotted on a location map showing the location of project site, habitation nearby, sensitive receptors, if any. ii. Water Quality modelling - in case of discharge in water body iii. Impact of the transport of the raw materials and end products on the surrounding environment shall be assessed and provided. In this regard, options for transport of raw materials and finished products and wastes (large quantities) by rail or rail-cum road transport or conveyor- cum-rail transport shall be examined. iv. A note on treatment of wastewater from different plant operations, extent recycled and reused for different purposes shall be included. Complete scheme of effluent treatment. Characteristics of untreated and treated effluent to meet the prescribed standards of discharge under E(P) Rules. v. Details of stack emission and action plan for control of emissions to meet standards. vi. Measures for fugitive emission control vii. Details of hazardous waste generation and their storage, utilization and management. Copies of MOU regarding utilization of solid and hazardous waste in cement plant shall also be included. EMP shall include the concept of waste-minimization, recycle/reuse/recover techniques, Energy conservation, and natural resource conservation. viii. Proper utilization of fly ash shall be ensured as per Fly Ash Notification, 2009. A detailed plan of action shall be provided. ix. Action plan for the green belt development plan in 33 % area i.e. land with not less than 1,500 trees per ha. Giving details of species, width of plantation, planning schedule etc. shall be included. The green belt shall be around the project boundary and a scheme for greening of the roads used for the project shall also be incorporated. x. Action plan for rainwater harvesting measures at plant site shall be submitted to harvest rainwater from the roof tops and storm water drains to recharge the ground water and also to use for the various activities at the project site to conserve fresh water and reduce the water requirement from other sources. xi. Total capital cost and recurring cost/annum for environmental pollution control measures shall be included. xii. Action plan for post-project environmental monitoring shall be submitted. STANDARD TERMS OF REFERENCE (TOR) FOR EIA/EMP REPORT FOR PROJECTS/ ACTIVITIES REQUIRING ENVIRONMENT CLEARANCE

xiii. Onsite and Offsite Disaster (natural and Man-made) Preparedness and Emergency Management Plan including Risk Assessment and damage control. Disaster management plan should be linked with District Disaster Management Plan. 8) Occupational health i. Plan and fund allocation to ensure the occupational health & safety of all contract and casual workers ii. Details of exposure specific health status evaluation of worker. If the workers' health is being evaluated by pre designed format, chest x rays, Audiometry, Spirometry, Vision testing (Far & Near vision, colour vision and any other ocular defect) ECG, during pre placement and periodical examinations give the details of the same. Details regarding last month analyzed data of above mentioned parameters as per age, sex, duration of exposure and department wise. iii. Details of existing Occupational & Safety Hazards. What are the exposure levels of hazards and whether they are within Permissible Exposure level (PEL). If these are not within PEL, what measures the company has adopted to keep them within PEL so that health of the workers can be preserved, iv. Annual report of heath status of workers with special reference to Occupational Health and Safety. 9) Corporate Environment Policy i. Does the company have a well laid down Environment Policy approved by its Board of Directors? If so, it may be detailed in the EIA report. ii. Does the Environment Policy prescribe for standard operating process / procedures to bring into focus any infringement / deviation / violation of the environmental or forest norms / conditions? If so, it may be detailed in the EIA. iii. What is the hierarchical system or Administrative order of the company to deal with the environmental issues and for ensuring compliance with the environmental clearance conditions? Details of this system may be given. iv. Does the company have system of reporting of non compliances / violations of environmental norms to the Board of Directors of the company and / or shareholders or stakeholders at large? This reporting mechanism shall be detailed in the EIA report 10) Details regarding infrastructure facilities such as sanitation, fuel, restroom etc. to be provided to the labour force during construction as well as to the casual workers including truck drivers during operation phase. 11) Enterprise Social Commitment (ESC) i. Adequate funds (at least 2.5 % of the project cost) shall be earmarked towards the Enterprise Social Commitment based on Public Hearing issues and item-wise details along with time STANDARD TERMS OF REFERENCE (TOR) FOR EIA/EMP REPORT FOR PROJECTS/ACTIVITIES REQUIRING ENVIRONMENT CLEARANCE

bound action plan shall be included. Socio-economic development activities need to be elaborated upon. 12) Any litigation pending against the project and/or any direction/order passed by any Court of Law against the project, if so, details thereof shall also be included. Has the unit received any notice under the Section 5 of Environment (Protection) Act, 1986 or relevant Sections of Air and Water Acts? If so, details thereof and compliance/ATR to the notice(s) and present status of the case. 13) 'A tabular chart with index for point wise compliance of above TOR.

B. SPECIFIC TERMS OF REFERENCE FOR EIASTUDIES FOR PESTICIDES INDUSTRY AND PESTICIDE SPECIFIC INTERMEDIATES (EXCLUDING FORMULATIONS)

1. Commitment that no banned pesticides will be manufactured. 2. Detailsonsolvents to be used,measuresfor solventrecovery and for emissions control. 3. Details of process emissions from the proposed unit and its arrangement to control. 4. Ambient air quality data should include VOC, other process- specific pollutants* like NH3*, chlorine*, HCl*, HBr*, H2S*, HF*, CS2 etc., (*-as applicable) 5. Work zone monitoring arrangements for hazardous chemicals. 6. Detailed effluent treatment scheme including ssegregation for units adopting 'Zero' liquid discharge. 7. Action plan for odour control to be submitted. 8. A copy of the Memorandum of Understanding signed with cement manufacturers indicating clearly that they co-process organic solid/hazardous waste generated. 9. Authorization/Membership for the disposal of liquid effluent in CETP and solid/hazardous waste in TSDF, if any. 10. Material Safety Data Sheet for all the Chemicals are being used/will be used. 11. Authorization/Membership for the disposal of solid/hazardous waste in TSDF. 12. Details of incinerator if to be installed. 13. Risk assessment for storage and handling of hazardous chemicals/solvents. Action plan for handling & safety system to be incorporated. 14. Arrangements for ensuring health and safety of workers engaged in handling of toxic materials.

*** STANDARD TERMS OF REFERENCE (TOR) FOR EIA/EMP REPORT FOR PROJECTS/ ACTIVITIES REQUIRING ENVIRONMENT CLEARANCE

5(f):STANDARD TERMS OF REFERENCE FOR CONDUCTING ENVIRONMENT IMPACT ASSESSMENT STUDY FOR SYNTHETIC ORGANIC CHEMICALS INDUSTRY (DYES & DYE INTERMEDIATES; BULK DRUGS AND INTERMEDIATES EXCLUDING DRUG FORMULATIONS; SYNTHETIC RUBBERS; BASIC ORGANIC CHEMICALS, OTHER SYNTHETIC ORGANIC CHEMICALS AND CHEMICAL INTERMEDIATES) AND INFORMATION TO BE INCLUDED IN EIA/EMP REPORT

A. STANDARD TERMS OF REFERENCE

1) Executive Summary 2) Introduction i. Details of the EIA Consultant including NABET accreditation ii. Information about the project proponent iii. Importance and benefits of the project 3) Project Description i. Cost of project and time of completion. ii. Products with capacities for the proposed project. iii. If expansion project, details of existing products with capacities and whether adequate land is available for expansion, reference of earlier EC if any. iv. List of raw materials required and their source along with mode of transportation. v. Other chemicals and materials required with quantities and storage capacities vi. Details of Emission, effluents, hazardous waste generation and their management. vii. Requirement of water, power, with source of supply, status of approval, water balance diagram, man-power requirement (regular and contract) viii. Process description along with major equipments and machineries, process flow sheet (quantative) from raw material to products to be provided ix. Hazard identification and details of proposed safety systems. x. Expansion/modernization proposals: c. Copy of all the Environmental Clearance(s) including Amendments thereto obtained for the project from MOEF/SEIAA shall be attached as an Annexure. A certified copy of the latest Monitoring Report of the Regional Office of the Ministry of Environment and Forests as per circular dated 30th May, 2012 on the status of compliance of conditions stipulated in all the existing environmental clearances including Amendments shall be provided. In STANDARD TERMS OF REFERENCE (TOR) FOR EIA/EMP REPORT FOR PROJECTS/ACTIVITIES REQUIRING ENVIRONMENT CLEARANCE

addition, status of compliance of Consent to Operate for the ongoing Iexisting operation of the project from SPCB shall be attached with the EIA-EMP report. d. In case the existing project has not obtained environmental clearance, reasons for not taking EC under the provisions of the EIA Notification 1994 and/or EIA Notification 2006 shall be provided. Copies of Consent to Establish/No Objection Certificate and Consent to Operate (in case of units operating prior to EIA Notification 2006, CTE and CTO of FY 2005-2006) obtained from the SPCB shall be submitted. Further, compliance report to the conditions of consents from the SPCB shall be submitted. 4) Site Details i. Location of the project site covering village, Taluka/Tehsil, District and State, Justification for selecting the site, whether other sites were considered. ii. A toposheet of the study area of radius of 10km and site location on 1:50,000/1:25,000 scale on an A3/A2 sheet. (including all eco-sensitive areas and environmentally sensitive places) iii. Details w.r.t. option analysis for selection of site iv. Co-ordinates (lat-long) of all four corners of the site. v. Google map-Earth downloaded of the project site. vi. Layout maps indicating existing unit as well as proposed unit indicating storage area, plant area, greenbelt area, utilities etc. If located within an Industrial area/Estate/Complex, layout of Industrial Area indicating location of unit within the Industrial area/Estate. vii. Photographs of the proposed and existing (if applicable) plant site. If existing, show photographs of plantation/greenbelt, in particular. viii. Landuse break-up of total land of the project site (identified and acquired), government/ private - agricultural, forest, wasteland, water bodies, settlements, etc shall be included. (not required for industrial area) ix. A list of major industries with name and type within study area (10km radius) shall be incorporated. Land use details of the study area x. Geological features and Geo-hydrological status of the study area shall be included. xi. Details of Drainage of the project upto 5km radius of study area. If the site is within 1 km radius of any major river, peak and lean season river discharge as well as flood occurrence frequency based on peak rainfall data of the past 30 years. Details of Flood Level of the project site and maximum Flood Level of the river shall also be provided. (mega green field projects) xii. Status of acquisition of land. If acquisition is not complete, stage of the acquisition process and expected time of complete possession of the land. xiii. R&R details in respect of land in line with state Government policy. STANDARD TERMS OF REFERENCE (TOR) FOR EIA/EMP REPORT FOR PROJECTS/ ACTIVITIES REQUIRING ENVIRONMENT CLEARANCE

5) Forest and wildlife related issues (if applicable): i. Permission and approval for the use of forest land (forestry clearance), if any, and recommendations of the State Forest Department. (if applicable) ii. Landuse map based on High resolution satellite imagery (GPS) of the proposed site delineating the forestland (in case of projects involving forest land more than 40 ha) iii. Status of Application submitted for obtaining the stage I forestry clearance along with latest status shall be submitted. iv. The projects to be located within 10 km of the National Parks, Sanctuaries, Biosphere Reserves, Migratory Corridors of Wild Animals, the project proponent shall submit the map duly authenticated by Chief Wildlife Warden showing these features vis-à-vis the project location and the recommendations or comments of the Chief Wildlife Warden-thereon. v. Wildlife Conservation Plan duly authenticated by the Chief Wildlife Warden of the State Government for conservation of Schedule I fauna, if any exists in the study area. vi. Copy of application submitted for clearance under the Wildlife (Protection) Act, 1972, to the Standing Committee of the National Board for Wildlife. 6) Environmental Status i. Determination of atmospheric inversion level at the project site and site-specific micro- meteorological data using temperature, relative humidity, hourly wind speed and direction and rainfall. ii. AAQ data (except monsoon) at 8 locations for PM10, PM2.5, SO2, NOX, CO and other parameters relevant to the project shall be collected. The monitoring stations shall be based CPCB guidelines and take into account the pre-dominant wind direction, population zone and sensitive receptors including reserved forests. iii. Raw data of all AAQ measurement for 12 weeks of all stations as per frequency given in the NAQQM Notification of Nov. 2009 along with - min., max., average and 98% values for each of the AAQ parameters from data of all AAQ stations should be provided as an annexure to the EIA Report. iv. Surface water quality of nearby River (100m upstream and downstream of discharge point) and other surface drains at eight locations as per CPCB/MoEF&CC guidelines. v. Whether the site falls near to polluted stretch of river identified by the CPCB/MoEF&CC, if yes give details. vi. Ground water monitoring at minimum at 8 locations shall be included. vii. Noise levels monitoring at 8 locations within the study area. viii. Soil Characteristic as per CPCB guidelines. ix. Traffic study of the area, type of vehicles, frequency of vehicles for transportation of materials, additional traffic due to proposed project, parking arrangement etc. STANDARD TERMS OF REFERENCE (TOR) FOR EIA/EMP REPORT FOR PROJECTS/ACTIVITIES REQUIRING ENVIRONMENT CLEARANCE

x. Detailed description of flora and fauna (terrestrial and aquatic) existing in the study area shall be given with special reference to rare, endemic and endangered species. If Schedule- I fauna are found within the study area, a Wildlife Conservation Plan shall be prepared and furnished. xi. Socio-economic status of the study area. 7) Impact and Environment Management Plan i. Assessment of ground level concentration of pollutants from the stack emission based on site-specific meteorological features. In case the project is located on a hilly terrain, the AQIP Modelling shall be done using inputs of the specific terrain characteristics for determining the potential impacts of the project on the AAQ. Cumulative impact of all sources of emissions (including transportation) on the AAQ of the area shall be assessed. Details of the model used and the input data used for modelling shall also be provided. The air quality contours shall be plotted on a location map showing the location of project site, habitation nearby, sensitive receptors, if any. ii. Water Quality modelling - in case of discharge in water body iii. Impact of the transport of the raw materials and end products on the surrounding environment hall be assessed and provided. In this regard, options for transport of raw materials and finished products and wastes (large quantities) by rail or rail-cum road transport or conveyor- cum-rail transport shall be examined. iv. A note on treatment of wastewater from different plant operations, extent recycled and reused for different purposes shall be included. Complete scheme of effluent treatment. Characteristics of untreated and treated effluent to meet the prescribed standards of discharge under E(P) Rules. v. Details of stack emission and action plan for control of emissions to meet standards. vi. Measures for fugitive emission control vii. Details of hazardous waste generation and their storage, utilization and management. Copies of MOU regarding utilization of solid and hazardous waste in cement plant shall also be included. EMP shall include the concept of waste-minimization, recycle/reuse/recover techniques, Energy conservation, and natural resource conservation. viii. Proper utilization of fly ash shall be ensured as per Fly Ash Notification, 2009. A detailed plan of action shall be provided. ix. Action plan for the green belt development plan in 33 % area i.e. land with not less than 1,500 trees per ha. Giving details of species, width of plantation, planning schedule etc. shall be included. The green belt shall be around the project boundary and a scheme for greening of the roads used for the project shall also be incorporated. x. Action plan for rainwater harvesting measures at plant site shall be submitted to harvest rainwater from the roof tops and storm water drains to recharge the ground water and also to STANDARD TERMS OF REFERENCE (TOR) FOR EIA/EMP REPORT FOR PROJECTS/ ACTIVITIES REQUIRING ENVIRONMENT CLEARANCE

use for the various activities at the project site to conserve fresh water and reduce the water requirement from other sources. xi. Total capital cost and recurring cost/annum for environmental pollution control measures shall be included. xii. Action plan for post-project environmental monitoring shall be submitted. xiii. Onsite and Offsite Disaster (natural and Man-made) Preparedness and Emergency Management Plan including Risk Assessment and damage control. Disaster management plan should be linked with District Disaster Management Plan. 8) Occupational health i. Plan and fund allocation to ensure the occupational health & safety of all contract and casual workers ii. Details of exposure specific health status evaluation of worker. If the workers' health is being evaluated by pre designed format, chest x rays, Audiometry, Spirometry, Vision testing (Far & Near vision, colour vision and any other ocular defect) ECG, during pre placement and periodical examinations give the details of the same. Details regarding last month analyzed data of above mentioned parameters as per age, sex, duration of exposure and department wise. iii. Details of existing Occupational & Safety Hazards. What are the exposure levels of hazards and whether they are within Permissible Exposure level (PEL). If these are not within PEL, what measures the company has adopted to keep them within PEL so that health of the workers can be preserved, iv. Annual report of heath status of workers with special reference to Occupational Health and Safety. 9) Corporate Environment Policy i. Does the company have a well laid down Environment Policy approved by its Board of Directors? If so, it may be detailed in the EIA report. ii. Does the Environment Policy prescribe for standard operating process / procedures to bring into focus any infringement / deviation / violation of the environmental or forest norms / conditions? If so, it may be detailed in the EIA. iii. What is the hierarchical system or Administrative order of the company to deal with the environmental issues and for ensuring compliance with the environmental clearance conditions? Details of this system may be given. iv. Does the company have system of reporting of non compliances / violations of environmental norms to the Board of Directors of the company and / or shareholders or stakeholders at large? This reporting mechanism shall be detailed in the EIA report STANDARD TERMS OF REFERENCE (TOR) FOR EIA/EMP REPORT FOR PROJECTS/ACTIVITIES REQUIRING ENVIRONMENT CLEARANCE

10) Details regarding infrastructure facilities such as sanitation, fuel, restroom etc. to be provided to the labour force during construction as well as to the casual workers including truck drivers during operation phase. 11) Enterprise Social Commitment (ESC) i. Adequate funds (at least 2.5 % of the project cost) shall be earmarked towards the Enterprise Social Commitment based on Public Hearing issues and item-wise details along with time bound action plan shall be included. Socio-economic development activities need to be elaborated upon. 12) Any litigation pending against the project and/or any direction/order passed by any Court of Law against the project, if so, details thereof shall also be included. Has the unit received any notice under the Section 5 of Environment (Protection) Act, 1986 or relevant Sections of Air and Water Acts? If so, details thereof and compliance/ATR to the notice(s) and present status of the case. 13) 'A tabular chart with index for point wise compliance of above TOR.

B. SPECIFIC TERMS OF REFERENCEFOREIASTUDIES FOR SYNTHETIC ORGANIC CHEMICALS INDUSTRY (DYES & DYE INTERMEDIATES; BULK DRUGS AND INTERMEDIATES EXCLUDING DRUG FORMULATIONS; SYNTHETIC RUBBERS; BASIC ORGANIC CHEMICALS, OTHER SYNTHETIC ORGANIC CHEMICALS AND CHEMICAL INTERMEDIATES)

1. Detailsonsolvents to be used,measuresfor solventrecovery and for emissions control. 2. Details of process emissions from the proposed unit and its arrangement to control. 3. Ambient air quality data should include VOC, otherprocess-specificpollutants* like NH3*, chlorine*, HCl*, HBr*, H2S*, HF*,etc.,(*-asapplicable) 4. Work zone monitoring arrangements for hazardous chemicals. 5. Detailed effluent treatment scheme including ssegregation of effluent streams for units adopting 'Zero' liquid discharge. 6. Action plan for odour control to be submitted. 7. A copy of the Memorandum of Understanding signed with cement manufacturers indicating clearly that they co-process organic solid/hazardous waste generated. 8. Authorization/Membership for the disposal of liquid effluent in CETP and solid/hazardous waste in TSDF, if any. 9. Action plan for utilization of MEE/dryers salts. 10. Material Safety Data Sheet for all the Chemicals are being used/will be used. 11. Authorization/Membership for the disposal of solid/hazardous waste in TSDF. STANDARD TERMS OF REFERENCE (TOR) FOR EIA/EMP REPORT FOR PROJECTS/ ACTIVITIES REQUIRING ENVIRONMENT CLEARANCE

12. Details of incinerator if to be installed. 13. Risk assessment for storage and handling of hazardous chemicals/solvents. Action plan for handling & safety system to be incorporated. 14. Arrangements for ensuring health and safety of workers engaged in handling of toxic materials.

*** Gujarat Industrial Development Corporation (A Govt. of Gujarat Undertaking) Office of the Regional Manager Plot No.624, Admn. Complex, GIDC Industrial Estate, Walia Road, Ankleshwar 393002 , Phone - (02646) 221351,221451,221403 , Mail Id - [email protected] , website:

No. GIDC/RM/ANK/TRF/FTO/DAH5/38 Date : 21/08/2018 Office Order

Sub: Transfer of Industrial Plot No. D-2-CH-275 at Dahej-II Industrial Estate

A Industrial Plot No. D-2-CH-275 admeasuring about 7054.30 Sq.mt. in Dahej-II estate. was allotted to JDB PHARMACEUTICAL PROJECT (P) LTD (1)JDB PHARMACEUTICAL PROJECT P LTD :100.00 %. The Lease Deed / Conveyance Deed / Licence Agreement was executed on 06/12/2012. The Lessee had applied to the Corporation for transfer of the said Industrial Plot in favour of MANBRO POLYMERS LIMITED Public Limited Company directors / shareholders (1)MANBRO POLYMERS LIMITED :100.00 %. Certain terms and conditions have been stipulated by the Regional Manager, Ankleshwar as per Provisional Transfer Order no. GIDC/RM/ANK/TRF/PTO/DAH5/50 dtd. 18/06/2018

Lessee has paid all dues of the Corporation up to Date. Lesse has also paid the Corporation's share in Transfer fee amounting to Rs.4195336.00 calculated @30.00% with GST, NU Penalty amounting to Rs.1118756.00 calculated @8.00% with GST and additional transfer fees amounting to Rs.(Nil) @ Rs.1680.00 per Sq.mt. The Deed of Supplementary Agreement has therefore been executed on 21/08/2018 between the Corporations, transferor & transferee. The plot now therefore stands transferred in the name of MANBRO POLYMERS LIMITED Public Limited Company MANBRO POLYMERS LIMITED with effect from 21/08/2018 for establishment of Acetic acid esters, Acetic acid, Monoglyceride, industry. This transfer permission shall not be considered as valid under the building bye-laws of the Corporation, if any unauthorized construction is carried out by Transferee. If any unauthorized construction is carried out, the same shall not be considered that Corporation has regularized the same. Transferee shall have to remove/demolish non violative construction or shall have to get approved from the Competent Authority. The water requirement as per transfer application is 2 KLD per year only.

Thanking you, Yours faithfully,

Regional Manager, G.I.D.C., Ankleshwar.

Page 1 of 2 To,

1. MANBRO POLYMERS LIMITED C-73, Shivaji Park, Punjabi Bagh, Delhi110026. Along with a copy of Deed of Supplementary Agreement

2. JDB PHARMACEUTICAL PROJECT (P) LTD 4, Paras Bunglows, Nr. Prahladnagar Garden, Prahladnagar, Ahmedabad-380015.

Copy To :

1. The Executive Engineer, GIDC, Ankleshwar. 2. Accounts Officer, GIDC, Ankleshwar. 3. Deputy Executive Engineer, GIDC, Ankleshwar. 4. EDP, GIDC, Ankleshwar.

Page 2 of 2 REVISION DATE 92.46 MT

GREEN BELT

F. P. STORAGE AREA

PLANT BUILDING AREA

AREA STATEMENT ETP AREA NO AREA SQ. MT. 1 SECURITY OFFICE 20 2 RAW MATERIAL STORAGE AREA 620 3 PLANT BUILDING AREA 900 4 F. P. STORAGE AREA 500

GREEN BELT 5 SOLVENT AND TANK FARM AREA 200 122.88 MT 6 UTILITY AREA 300 7 ETP AREA 550 8 ADMIN BUILDING AREA 135 109.40 MT UTILITY AREA 9 GREEN BELT 1625 RAW MATERIAL STORAGE AREA 10 OPEN/INTERNAL ROAD AREA 1971 A New Project For: 11 PARKING 150 Dahej 2, Dist. Bharuch 392110

TOTAL 7054 M\S. Manbro Polymers Limited, Plot No. D-2/CH-275, Industrial Estate

SOLVENT AND TANK FARM AREA

ADMIN BUILDING AREA LAYOUT PLAN GROUND FLOOR PLANT

JOB: XXXXX DWN: HP PARKING CHK: HP SECURITY DATE: 09/01/2019 OFFICE SHEET GATE 36.50 MT E1.0 Scanned by CamScanner Scanned by CamScanner Scanned by CamScanner Scanned by CamScanner

ANNEXURE - VII - MONITORING SAMPLING DATES (MARCH-APRIL-MAY) Month of Project Site Jolva Samatpor Sambheti Dahej Town Ambhetha Vadadala Vav Monitorong (A1) (A2) (A3) (A4) (A5) (A6) (A7) (A8) 01-03-18 06-03-18 09-03-18 09-03-18 09-03-18 06-03-18 02-03-18 01-03-18 03-03-18 02-03-18 07-03-18 07-03-18 07-03-18 02-03-18 06-03-18 04-03-18 04-03-18 08-03-18 10-03-18 10-03-18 10-03-18 03-03-18 03-03-18 08-03-18 15-03-18 13-03-18 12-03-18 12-03-18 12-03-18 13-03-18 13-03-18 15-03-18 Mar-18 11-03-18 16-03-18 14-03-18 17-03-18 17-03-18 16-03-18 16-03-18 11-03-18 25-03-18 18-03-18 21-03-18 21-03-18 21-03-18 18-03-18 18-03-18 25-03-18 22-03-18 17-03-18 24-03-18 24-03-18 24-03-18 17-03-18 17-03-18 22-03-18 27-03-18 28-03-18 29-03-18 29-03-18 29-03-18 28-03-18 28-03-18 27-03-18 02-04-18 04-04-18 05-04-18 05-04-18 05-04-18 04-04-18 04-04-18 02-04-18 09-04-18 07-04-18 08-04-18 08-04-18 08-04-18 07-04-18 07-04-18 09-04-18 14-04-18 11-04-18 12-04-18 12-04-18 12-04-18 11-07-18 11-07-18 14-04-18 13-04-18 14-04-18 15-04-18 15-04-18 15-04-18 14-04-18 14-04-18 13-04-18 Apr-18 15-04-18 16-04-18 19-04-18 19-04-18 19-04-18 16-04-18 16-04-18 15-04-18 22-04-18 21-04-18 22-04-18 22-04-18 22-04-18 21-04-18 21-04-18 20-04-18 23-04-18 25-04-18 26-04-18 26-04-18 26-04-18 28-04-18 28-04-18 24-04-18 24-04-18 28-04-18 29-04-18 29-04-18 29-04-18 25-04-18 25-04-18 27-04-18 06-05-18 02-05-18 04-05-18 01-05-18 01-05-18 01-05-18 01-05-18 02-05-18 04-05-18 07-05-18 06-05-18 06-05-18 06-05-18 06-05-18 05-05-18 04-05-18 08-05-18 10-05-18 16-05-18 14-05-18 14-05-18 09-05-18 09-05-18 07-05-18 17-05-18 12-05-18 17-05-18 16-05-18 16-05-18 12-05-18 12-05-18 12-05-18 May-18 18-05-18 18-05-18 20-05-18 17-05-18 17-05-18 17-05-18 17-05-18 16-05-18 25-05-18 19-05-18 23-05-18 25-05-18 25-05-18 20-05-18 18-05-18 20-05-18 26-05-18 26-05-18 24-05-18 24-05-18 24-05-18 22-05-18 21-05-18 23-05-18 29-05-18 28-05-18 27-05-18 26-05-18 26-05-18 25-05-18 25-05-18 24-05-18 Project Site Ambetha Sambheti Dahej Vadadla Vav Jolva Samatpor Location Noise (N1) (N2) (N3) (N4) (N5) (N6) (N7) (N8) Date of Sampling 02-03-18 03-03-18 12-03-18 17-03-18 12-03-18 06-03-18 16-03-18 04-03-18 Project Site AmbethaDahej (GW3) Vadadla Jolva Vav Suva Galenda Location Ground Water (GIDC Water)(GW2) (GW4)(GW5) (GW6) (GW7) (GW8) Date of Sampling 01-03-18 04-03-18 24-03-18 26-03-18 28-03-18 15-03-18 12-03-18 29-03-18 Narmadaestuar Vadadla- Vav - Jolva - y Location SurfaceWater (SW1) Pond Pond Pond (SW4) Date of Sampling 02-03-18 01-03-18 07-03-18 04-03-18 Dahej Project Site Location Ambetha (S2) (S3) Vadadla (S4) Jolva (S5) Vav (S6) Suva (S7) Soil Sample (S1) Date of Sampling 01-03-18 24-03-18 09-03-18 06-03-18 07-03-18 09-03-18 02-03-18

Environment,Health andSafetyPolicy Manbro Polymers, as manufacturers of Intermediates of Agrochemicals and Synthetic organic Chemicals must ensure working conditions will be clean, orderly and safe; encourage better health and education; and maintain in good order the property we are privileged to use, protecting the environment and natural resources. Our efforts shall be to: • Adhere to Quality standards of all Products. • Use r esources efficiently through proper technological measures and effective management practices. • We shall meet or exceed all applicable EHS regulations, Company standards and voluntary initiatives to which we subscribe. Each employee has a responsibility to comply with EHS legal requirements. • We provide a culture of safety for our employees, contractors, and key partners. We fulfil this responsibility whether in manufacturing, in a laboratory, in an office, or in a vehicle • To manage our environmental risks, we pursue a path of continual improvement, investigating, assessing, understanding, and improving environmental aspects and impacts using robust management systems.

For, Manbro Polymers

UNDERTAKING

I/Mr. Amit Garg, Director of M/s. Manbro Polymers Limited, is located at Plot No. D- 2/CH-275, Industrial Estate, Dahej 2, District: Bharuch, Gujarat, India. Do hereby undertake as under:

1) We have applied for Environment Clearance in 5(b) & 5(f) category for new proposed application of Intermediates of Agro chemicals and Synthetic Organic Chemicals at above mention location to Ministry of Environment Forest & Climate Change, New Delhi. 2) As part of EC process, we have prepared EIA report. 3) Unit will not dig bore-well for fresh water. 4) The ownership of EIA report remains with us. 5) The data presented in EIA report is true and describes all details of the project. 6) We will be responsible for any factual discrepancy in EIA report. 7) We will not manufacture any type of banned pesticides at plant premises. Our proposed products is one of the technical grade pesticides, its end use as herbicide and not covered under banned category of pesticides/chemicals in the country.

I hereby give an undertaking that the above data and information in enclosures are true to the best of my knowledge and the same I believe to be true.

Date: 04-02-2019 For, Manbro Polymers Limited

Place: Dahej

Authorize Signatory

Sr Name & Address Of the Company Plot No. Contact Person & Designation No

Shri K. Satyanarayna Chief Executive Officer

Mr. Gopal Jee Rai ONGC Petro additions Ltd. General Manager (M) 1 (OPaL) Z/1, Z/83 & Z/83/1 Mr. Y.R. Johri Chief Enginner (C&M)

Mr. R. N. Mohanty President - Technology

Pidilite Industries Ltd. Mr. Satish Shah 2 Z/2 Consultant

Mr. Kavit Pandya Chief - Engineering Mr. A.D. Chatterjee Managing Director

Mr. T.B. Chatterjee Sr. Executive Vice President (Corporate Affiairs & Legal) DIC Fine Chemicals Pvt. Ltd. 3 Z/3 Mr. Prashant Limaye Director - Operation

Mr. Amit Upadhyay Purchase Manager

Mr. Sanjay Gupta Neesa Infrastructure Ltd. 4 Z88/3 & Z/88/2 (Chairman)

Mr. R. Mishra Executive Vice President Manufacturing & Supply Chain Indofil Industries Ltd. 5 Z/8 Dr.ALN Rao VP-Mfg.

Firmenich Aromatics Production (India) Mr. Sanjay Kalyankar 6 Pvt. Ltd. Z/10 (Project Manager) (M) 09099974532 / 09967538960 Mr. S C Damani (Propritor) Glomet Technologies Pvt. Ltd. 7 Z/22 Mr. Jayesh Damani Mr. Lalit K. Patel (Director)

Mr. Maheshchand Rathi 8 Z/6 Vice President - Finance & Accts. Meghmani Industies Ltd. Mr. Manohar Maheshwari GM (Commercial)

Mr. Deepak Mehta (Director) Sarju Impex Limited 9 Z/13 Mr. Kalpesh Kamdar

Mr. Vipul Patel

Mr. Ramesh Patel (Director) Meghmani Organics Ltd. 10 Z/31 & Z/32 Mr. Kishan Lalwani Authorised Signatory

Mr. Umesh M. Mendapara Meghmani Unichem Limited Liability CEO 11 Partnership Z/34 Mr. Vijay Shah Mr. A.E. Rayani Panama Petrochem Ltd. 12 Z/23 & Z/24 Mr. P.V. Nikkam (General Manager)

DGEN Project Mr. Jigish B. Mehta Vice President (Projects) Torrent Energy Ltd. 13 Z/9 Mr. Rajendra Bahuguna General Manager (P&A Deptt.)

Mr.Amit Raj Sinha Managing Director Sigachi Cellulos Pvt. Ltd. 14 Z/16 Mr. Vijay A. Bhavsar Director

Mr Rajesh Pokerna

Mr. Sunil Kumar Jain P&J Cretechem (P) Ltd. 15 Z/17 & Z/18 Director

Mr. Prakash Jain Director Mr. S.M. Bhingaradia Director / Partner Ramdev Chemical Industries 16 Z/19 Mr. Rajiv Shah Project Manager

Mr. D.C. Sharma Gujarat Dyestuff Industries 17 Z/25, Z/26, Z/27 & Z/28 Director

Mr. Sudhir V.Valia (Director)

Mr. Mukesh R. Patel Sun Pharmaceutical Industries Ltd. Sr. Manager (Operations) 18 Z/15 Mr. Ghanshyam Patel (Factory Manager)

CS Performance Chemicals Pvt. Ltd. 19 Z/33 Mr. Sandeep Zaveri 19- CS Performance Chemicals Pvt. Ltd. Z/76 & Z/77 A Mr. Volker Christmann (Director) Roxul Rockwool Insulation India Pvt. Ltd. 20 Z/4 Mr. Joergen Amtoft Technical Director

Mr. K.I. Patel Aries Colorchem Pvt. Ltd. 21 Z/29 & Z/30

Tiong Woon Project & Contracting Pte. Mr. Sowrirjan 22 Ltd. Z/88/1 (India Country Manager)

Vinay Kumar Gujarat State Petronet Limited 23 Z//7 (Executive Director)

Mr. Jayesh Trivedi Breeze Intermediates Pvt. Ltd. Dirctor 24 Z/39

Mr. H.A. Modi SDE EB

Mr. M.M. Patel Bharat Sanchar Nigam Limited AGM (CFA/Sales) 25 Z/14/1 Mr. Rajesh Kanungo Add. GM (Planning) Mr. Pawan Kumar Mittal COO

Mr. Narendra Varma Shiva Pharmachem Ltd. 26 Z/88 & Z/88/4 Head - Projects

Mr. Swarup R. Deshpande Project Head

Mr. Harish Jajodia Neobags Overseas Pvt. Ltd. Managing Director 27 Z/73, Z/74 & Z/75

Mr. Inder Dhanraj Jain Chairman & Managing Director

28 APPL Industries Ltd. Z/45, Z/46 & Z/47 Mr. Aalekh Jain Director

Mr. Prashant Ruia (Director) Survival Technologies Pvt. Ltd. 29 Z/71 & Z/72 Mr. R.K. Dixit (Director)

Mr. Kapil Sharma Euclid Constructions Ltd. Asst. General Manager 30 Z/68

Mr. Shivkumar Arora Arora Sales Agency 31 Z/69 Proprietor

Mr. Rohit Singhal Director Fernas Construction India Pvt. Ltd. 32 Z/55 Mr. Vishal Agarwal Sr. Manager – Taxation

Indo Baijin Chemicals Pvt. Ltd. Mr. R. Mishra 33 Z/7/1 Chief Operating Officer

Mr. R. Mishra Executive Vice President Manufacturing & Supply Chain Division

Indofil Industries Ltd. Dr.ALN Rao 34 Z/21/1 VP-Mfg.

Mr. S.N.Pandey DGM – Mfg.

Mr.Dipnarayan Bhattacharya Bitumode International Pvt. Ltd. Managing Director 35 Z/43 & Z/44 Mr. Charukirti B. Shirsode Director

Mr. Vinay V. Deshmane Director Avalon Agro Products Pvt. Ltd. 36 Z/35, Z/36, Z/37 & Z/38 Mr. Kaustubh P. Karajgi Director

Mr. Atul Arun Bidkar Project Manager

Mr. Vasant Patel Accent Microcell Pvt. Ltd. 37 Z/59, Z/60, Z/63 & Z/64 CEO

Mr. M.L. Khandelwal Chairman Unique Techno Associates Pvt. Ltd. Mr. Vimal Gupta 38 Z/41 & Z/42 Director

Mr. Navneet Khandelwal Director Mr. Tarun Kudal Babaji Shivram Cleaning & Carriers Pvt. Director Ltd. 39 (Plot No. Z/70) Z/70 Mr. Dhaval Dhavda General Manager

Macson Color Chem Pvt. Ltd. Mr. Piyush N. Patel 40 Z/12/2 Director

Palvi Power Tech Sales Pvt. Ltd. Mr. Himanshu G. Mehta (Plot Nos. Z/78, Z/79) 41 Z/78 & Z/79 CEO

Mr. Sumanta Kumar Chatterjee Astra Speicalty Compounds India Pvt. Ltd. 42 Z/56, Z/57, Z/58, Z/65, Z/66 & Z/67 Director

Prakash Chemicals International Pvt. Ltd. Mr. Manish Shah (Plot Nos. Z/53, Z/54) Managing Director 43 Mr. Vishwas Makwana "Prakash House" Associate General Manager 39/40, Krishna Industrial Estate Gorwa Road, Vadodara - 390 016 Mr. Lalit Prasad Gupta Artee Pesticides 44 Z/52 Managing Partner

Hanzi Healthcure Pvt. Ltd. Mr. Puneet Mittal 45 Z/62 Director Central Railside Warehouse Company Ltd. Mr. P.K. Jain 46 Z/81 & Z/82 Superientending Engineer

Mr. Anmol Kamdar Annie Chemie Pvt. Ltd. 47 Z/40 Director

Swarnim DahejSpring Desalination Pvt. Mr. Girish Babu Bhat 48 Z/84/2 Ltd. Director, BD, India Mr. Anmol Kamdar Ana Industries Pvt Ltd. 49 Z/61 Director

J. P. Intrenational Mr. Nileshbhai H. Chauhan 50 Z/51 Partner Dev Intrenational Mr. Nileshbhai H. Chauhan 52 Z/50 Partner

Oil and Naturl Gas Corporation Ltd. C2- Mr. P.V. Satyaprakash 53 C3 Plant – Dahej 7/D General Manager (P)

Godrej & Boyce Mfg. Co. Ltd. Mr. Nitin Palan 54 Z/90 Sr. General Manager & Head Project 54- Godrej & Boyce Mfg. Co. Ltd. Z/91 A Mr. Rakesh K. Mistry ISGEC Heavy Engineering Ltd. 55 Z89 Mr. M.L. Bajaj AVP Mr. Joselind John Rallis India Ltd. General Manager 56 Z/110

Mr. M. P. Aggarwal Chairman Sajjan Specialty Ltd. 57 Z/107 Mr. Kartikeya Maheshwari Director

Torrent Energy Ltd. Mr. Zaver Goti 58 Z/21/ & Z/101/1 Asst General Manager

Torrent Pharmaceuticals Ltd. Mr. Ketan Joshi 59 Z/104, Z/105 & Z/106 (General Manager - Finance)

Mr. Rajendra Gaitonde Fermenta Biotech Ltd. 60 Z/109/B & Z/109/C Director - Operations

Vinay Kumar Gujarat State Petronet Limited 61 Z/112/A (Executive Director)

Coromandel International Limited Mr. Ravindra Patil 62 Z/103/G Sr. Manager - Quality Mr. H.A. Modi Bharat Sanchar Nigam Limited SDE EB 63 Z/100/1

Hindusthan M-I Swaco Limited Mr. Venket Subramaniyam DGM - Tech 64 Z/109/A

Glenmark Generics Limited 65 Z/103/I Mr. Mukesh Gangwani GM (Mfg.)

Mr. A.V. Jayraman Vijay Tanks & Vessels Ltd. 66 Z/100/2 General Manager

Mr. Madan Mohanka CMD Tega Industries (SEZ) Ltd. 67 Z/103/J Mr. Mehul Mohanka Director

Mr. Shekhar R. Somani Tatva Chintan Pharma Chem Pvt. Ltd. 68 Z/103/F/1 & Z/103/F2 Director

Mr. Gaurav Mohatta Director Benzo Chem Industries Pvt. Ltd. 69 Z/103/D Mr. Pawan Deora Manager (Import-Export)

Mr. KKS Babu Vice President

Mr. Kirit Shashtri 70 Aarti Industries Ltd. Z/103/H Manager (Liasion)

Mr. Ajay Mori Manager (Project)

Mr. Rajesh Patel Ajanta Pharma Limited Sr. G.M. - Projects 71 Z/103/A Mr. Robin Antony Asst. Manager - Projects Mr. Kanubhai P. Patel Director Raks Pharma Pvt. Ltd. Mr. Sureshbhai P. Patel 72 Z/111/A Director

Mr. Kalpesh R. Bhatt Sr. GM - Excise & HR

Holtec Asia Pvt. Ltd. Mr. Niraj Chaudhary 73 Z103/E Director Mr. Upendra Madan Deshpande 74 Milan Laboratories (I) Pvt. Ltd. Z/96/A Director Thermax Ltd. Mr. S. V. Deshmukh 75 Z/96/C Sr. Manager - Quality systems & BPMO Dorf Ketal Chemicals Pvt. Ltd. Mr. Naresha Aggarwal 76 Z/108 Director- Project Neogen Chemicals Ltd Dr. Harin Kanani 77 Z/96/B Executive Director

Yashashvi Rasayan Pvt. Ltd. Mr. Harsh Patel 78 Z/96/E Director

Camlin Fine Sciences Ltd. Mr. Arjun S. Dukane 79 Z/96/D Sr. VP. MFG. Tech. Tech. & Project Yashashvi Rasayan Pvt. Ltd. Mr. Harsh Patel 80 Z/109 Director Powerband Ind. Pvt. Ltd. Z/103/B Harsh Desai 81 Executive Director

Trustin Tape Pvt. Ltd Z111/E Pratik Singh 82 Associate Vice President 83 Hema Dyechem Pvt. Ltd. Z/112/B Mr. Shashank Merchant

Part - III - Non Processing Area Mr. Vipul Thakkar MD (M) 9825412519 Mr. Kuldeep Singh Sapthagiri Hospitality Pvt. Ltd. (M) 8000813557 84 Z/4/3 Ms. Sangita Puranik (M) 9925029172 Mr. Sumit Soni Manager (M) 9925039011 Mr. Shibu Pillai Cambay SEZ Hotels Pvt. Ltd. G.M. 85 Z/4/1 EIA REPORT OF M/s Manbro Polymers Limited, Plot No. D‐2/CH‐275,Industrial Estate, Dahej‐2, Dist. Bharuch, Gujarat.

ANNEXURE‐VIII ‐ TRAFFIC SURVEY REPORT Traffic count from Bharuch to Dahej (SH‐6) The 24 hours, hourly survey has been carried out. The details of the traffic is as per the below table. TRAFFIC SURVEY: BHARUCH TO DAHEJ Time Bicycle 2 Wheeler Auto Car Bus/Truck LCV Others PCU/Hour 27 October 2017 11:00 to 12:00 0 73 32 79 84 95 0 532.5 12:00 to 13:00 0 42 27 53 62 73 0 389.2 13:00 to 14:00 0 33 19 46 65 76 0 382.9 14:00 to 15:00 0 22 16 49 52 69 0 328.6 15:oo to 16:00 0 27 19 59 68 63 0 383.7 16:00 to 17:00 0 33 22 46 73 79 0 414.1 17:00 to 18:00 0 39 29 80 59 54 0 381.1 18:00 to 19:00 0 41 39 79 89 74 0 509.1 19:00 to 20:00 0 43 28 73 65 40 0 373.5 20:00 to 21:00 1 43 24 53 53 49 0 326.6 21:00 to 22:00 0 27 18 45 44 39 0 263.1 22:00 to 23:00 0 23 13 49 41 32 0 241.3 23:00 to 0:00 0 14 6 41 36 38 0 215.2 28 October 2017 0:00 to 1:00 0 6 4 23 19 28 0 126.2 1:00 to 2:00 0 8 9 24 21 21 0 129.4 2:00 to 3:00 0 4 4 28 16 23 0 114.2 3:00 to 4:00 0 3 0 12 22 9 0 92.1 4:00 to 5:00 0 5 0 17 28 12 0 120.3 5:00 to 6:00 0 0 3 21 18 17 0 101.8 6:00 to 7:00 2 23 7 38 44 28 0 228.7 7:00 to 8:00 0 37 11 68 53 54 0 332.1 8:00 to 9:00 3 49 18 70 61 62 1 383.8 9:00 to 10:00 0 57 11 101 66 58 0 419.7 10:00 to 11:00 1 74 18 98 89 67 0 514.3

EIA REPORT OF M/s Manbro Polymers Limited, Plot No. D‐2/CH‐275,Industrial Estate, Dahej‐2, Dist. Bharuch, Gujarat.

BHARUCH TO DAHEJ 60

50 Bicycle 40 2 Wheeler

VEHICLE

OF Auto 20

NO Car 10 Bus/Truck 0 11:0012:0013:0014:0015:oo16:0017:0018:00 19:00 20:00 21:00 22:00 23:00 0:00 1:00 2:00 3:00 4:00 5:00 6:00 7:0 0 8:00 9:00 10:00 LCV to to to to to to to to to to to to to to to to to to to to to to to to Others 12:0013:0014:0015:0016:0017:0018:0019:00 20:0021:0022:0023:000:00 1:00 2:00 3:00 4:00 5:00 6:00 7:00 8:0 0 9:00 10:0011:00 TIME The total one way traffic is 4751 during 24 hours. The column chart shows different types of vehicles passing from Bharuch to Dahej during every hour of day. Total No. Of bicycle: 7, 2 Wheeler: 726, Auto: 377, Car: 1252, Truck/Bus: 1228, LCV:1160 and Other vehicles:1 are passing fro m survey point from Bharuch to Dahej. PCU/Hour

300

200

100 PCU/Hour 0

The column chart shows values of Passenger Car Unit(PCU) for every hour.From the chart we can see that the value of Passenger Car Unit is minimum for 3:00 to 4:00 and maximum for 11:00 to 12:00.

EIA REPORT OF M/s Manbro Polymers Limited, Plot No. D‐2/CH‐275,Industrial Estate, Dahej‐2, Dist. Bharuch, Gujarat.

BHARUCH TO DAHEJ 0.13% 0.88% Bicycle

15.83% 2 23.72% Wheeler Auto

20.46% Car 7.63%

31.35%

The pie chart shows that various type and number of vehicle are travelling from Bharuch to Dahej. The details show that maxim um cars are travelling from Bharuch to Dahej and minimum other vehicles are travelling during surveyperiod.

JYOTI OM CHEMICAL RESEARCH CENTRE PVT. LTD. EIA REPORT OF M/s Manbro Polymers Limited, Plot No. D‐2/CH‐275,Industrial Estate, Dahej‐2, Dist. Bharuch, Gujarat.

Traffic count from Dahej to Bharuch (SH‐6) The 24 hours, hourly survey has been carried out. The details of the traffic is as per the below table.

TRAFFIC SURVEY: DAHEJ TO BHARUCH Time Bicycle 2 Wheeler Auto Car Bus/Truck LCV Others PCU/Hour 27 October 2017 11:00 to 12:00 2 115 18 125 77 88 0 554.7 12:00 to 13:00 0 88 27 110 68 76 0 491.4 13:00 to 14:00 0 75 23 103 56 68 0 426.7 14:00 to 15:00 1 62 21 98 58 74 0 427.6 15:00 to 16:00 0 53 28 91 67 69 0 443.1 16:00 to 17:00 0 61 9 108 78 62 0 468.3 17:00 to 18:00 0 68 25 116 71 77 0 495.8 18:00 to 19:00 1 97 27 121 95 85 0 600.5 19:00 to 20:00 0 65 13 98 62 44 0 391.1 20:00 to 21:00 0 51 8 87 48 52 0 337.3 21:00 to 22:00 0 35 5 71 41 35 0 265.5 22:00 to 23:00 0 21 3 40 50 36 0 253.9 23:00 to 0:00 0 11 0 32 32 31 0 176.9 28 October 2017 0:00 to 1:00 0 3 0 15 21 24 0 113.1 1:00 to 2:00 0 0 1 8 26 19 0 113.6 2:00 to 3:00 0 0 0 4 12 16 0 62.4 3:00 to 4:00 0 3 1 12 27 7 0 105.3 4:00 to 5:00 0 18 0 18 23 18 0 121.2 5:00 to 6:00 0 28 10 33 17 12 0 124.8 6:00 to 7:00 1 47 18 48 41 23 0 244.7 7:00 to 8:00 0 59 27 67 58 48 0 364.7 8:00 to 9:00 0 71 35 65 69 65 1 435 9:00 to 10:00 1 85 24 81 70 75 0 462.5 10:00 to 11:00 2 98 29 109 91 86 0 580.4

JYOTI OM CHEMICAL RESEARCH CENTRE PVT. LTD. EIA REPORT OF M/s Manbro Polymers Limited, Plot No. D‐2/CH‐275,Industrial Estate, Dahej‐2, Dist. Bharuch, Gujarat.

40 DAHEJ TO BHARUCH VEHICLE 30

NO 10

11:00 12:00 13:00 14:00 15:oo 16:00 17:00 18:00 19:00 20:00 21:00 22:00 23:00 0:00 to1:00 to2:00 to3:00 to4:00 to5:00 to6:00 to7:00 to8:00 to9:00 to 10:00

to to to to to to to to to to to to to0:00 1:00 2:00 3:00 4:00 5:00 6:00 7:00 8:00 9:00 10:00 to

12:00 13:00 14:00 15:00 16:00 17:00 18:00 19:00 20:00 21:00 22:00 23:00 11:00

TIME Bicycle 2 Wheeler Auto Car Bus/Truck LCV Others The total one way traffic is 5683 vehicles in 24 hour. The column chart shows different types of vehicles passing from Dahej to Bharuch every hour of day. Total No. Of bicycle: 8,2 Wheeler: 1214, Auto:352, Car:1660, Bus/Truck: 1258, LCV:1190 and Other vehicles:1 are passing from survey point from Dahej toBharuch.

JYOTI OM CHEMICAL RESEARCH CENTRE PVT. LTD. EIA REPORT OF M/s Manbro Polymers Limited, Plot No. D‐2/CH‐275,Industrial Estate, Dahej‐2, Dist. Bharuch, Gujarat.

Bicycle Others 0.88% 0.13% LCV 2 Wheeler 15.83% 23.72%

DAHEJ TO BHARUCH

Auto Bus/Truck 7.63% 20.46%

Car 31.35%

The pie chart shows that various type and number of vehicle are travelling from Dahej To Bharuch. The details show that maximum cars are travelling from Dahej to Bharuch and minimum other vehicles are travelling during survey period.

PCU/Hour

250 200

150

100 50

0 11:00 12:00 13:00 14:00 15:oo 16:00 17:00 18:00 19:00 20:00 21:00 22:00 23:00 0:00 1:00 2:00 3:00 4:00 5:006:0 0 7:00 8:00 9:0010:00 to to to to to to to to to to to to to to to to to to to to to to to to 12:00 13:00 14:00 15:00 16:00 17:00 18:00 19:00 20:00 21:00 22:00 23:00 0:00 1:00 2:00 3:00 4:00 5:00 6:007:0 0 8:00 9:00 10:0011:00

The column chart shows values of Passenger Car Unit(PCU) for every hour.From the chart we can see that the value of Passenger Car Unit is minimum for 2:00 to 3:00 and maximum for 18:00 to 19:00.

JYOTI OM CHEMICAL RESEARCH CENTRE PVT. LTD. EIA REPORT OF M/s Manbro Polymers Limited, Plot No. D‐2/CH‐275,Industrial Estate, Dahej‐2, Dist. Bharuch, Gujarat.

TRAFFIC SURVEY: SH‐06 TO SH‐206 Time Bicycle 2 Wheeler Auto Car Bus/Truck LCV Others PCU/Hour 27 October 2017 11:00 to 12:00 3 24 13 28 12 7 1 100.3 12:00 to 13:00 1 13 9 19 7 4 0 61.1 13:00 to 14:00 0 16 11 21 10 6 0 78.4 14:00 to 15:00 0 18 8 24 8 8 1 77.7 15:oo to 16:00 2 19 4 28 7 3 0 66.7 16:00 to 17:00 0 16 5 39 13 7 0 100.8 17:00 to 18:00 0 18 7 29 8 3 0 73.2 18:00 to 19:00 1 24 4 22 22 9 0 116.6 19:00 to 20:00 0 17 7 18 10 16 0 85.9 20:00 to 21:00 0 23 9 21 13 13 0 98.7 21:00 to 22:00 0 14 5 16 9 17 0 78.8 22:00 to 23:00 0 9 3 13 12 18 0 81.7 23:00 to 0:00 0 7 3 10 8 12 0 57.3 28 October 2017 0:00 to 1:00 0 4 1 8 6 11 0 44.4 1:00 to 2:00 0 1 0 6 4 8 0 29.7 2:00 to 3:00 0 0 0 2 4 6 0 22.4 3:00 to 4:00 0 0 0 0 0 1 0 1.4 4:00 to 5:00 0 2 1 6 9 4 0 40.6 5:00 to 6:00 0 6 2 11 11 6 0 57.4 6:00 to 7:00 2 19 4 23 19 9 0 106.1 7:00 to 8:00 0 23 5 31 22 12 0 130.3 8:00 to 9:00 1 28 7 43 34 23 0 198.2 9:00 to 10:00 3 33 5 34 42 19 0 208.1 10:00 to 11:00 1 45 9 49 37 31 0 234.9

JYOTI OM CHEMICAL RESEARCH CENTRE PVT. LTD. EIA REPORT OF M/s Manbro Polymers Limited, Plot No. D‐2/CH‐275,Industrial Estate, Dahej‐2, Dist. Bharuch, Gujarat.

SH‐06 TO SH‐206 60 Bicycle 50 2 Wheeler 40 Auto VEHICLE 30 OF 20 Car

NO 10 Bus/Truck 0 LCV Others

TIME The total one way traffic is 1598 during 24 hours. The column chart shows different types of vehicles passing from SH‐06 to SH‐206 during every hour of day. Total No. Of bicycle: 14, 2 Wheeler: 379, Auto: 122, Car: 501, Truck/Bus: 327, LCV: 253 and Other vehicles: 2 are passing fro m survey point from SH‐06‐ to SH‐206.

SH‐06 TO SH‐206 0.13% 0.88% Bicycle 15.83% 2 Wheeler 23.72% Auto Car 20.46% Bus/Truck 7.63% LCV Others

31.35%

The pie chart shows that various type and number of vehicle are travelling from SH‐06 to SH‐206. The details show that maximum cars are travelling from SH‐06 to SH‐206 and minimum other vehicles are travelling during survey period.

JYOTI OM CHEMICAL RESEARCH CENTRE PVT. LTD. EIA REPORT OF M/s Manbro Polymers Limited, Plot No. D‐2/CH‐275,Industrial Estate, Dahej‐2, Dist. Bharuch, Gujarat.

PCU/Hour

2000 1500 1000 500 0 PCU/Hour

The column chart shows values of Passenger Car Unit(PCU) for every hour.From the chart we can see that the value of Passenger Car Unit is minimum for 3:00 to 4:00 and maximum for 19:00 to20:00.

JYOTI OM CHEMICAL RESEARCH CENTRE PVT. LTD. EIA REPORT OF M/s Manbro Polymers Limited, Plot No. D‐2/CH‐275,Industrial Estate, Dahej‐2, Dist. Bharuch, Gujarat.

TRAFFIC SURVEY: TOWARDS ACL Time Bicycle 2 Wheeler Auto Car Bus/Truck LCV Others PCU/Hour 27 October 2017 11:00 to 12:00 0 52 19 22 13 0 0 106 12:00 to 13:00 0 53 12 37 38 0 0 189.5 13:00 to 14:00 0 42 8 42 42 2 0 199.8 14:00 to 15:00 0 18 6 33 22 3 0 118.2 15:oo to 16:00 0 15 5 24 18 5 0 97.5 16:00 to 17:00 1 23 8 32 29 3 0 142.7 17:00 to 18:00 1 13 6 22 15 10 0 93.5 18:00 to 19:00 2 28 8 29 22 14 1 138.1 19:00 to 20:00 1 12 4 14 17 12 0 91.8 20:00 to 21:00 0 9 5 12 12 9 0 70.1 21:00 to 22:00 0 7 4 16 14 11 0 80.9 22:00 to 23:00 0 5 2 11 11 9 0 61.1 23:00 to 0:00 0 3 1 9 12 7 0 57.3 28 October 2017 0:00 to 1:00 0 3 1 4 7 3 0 31.7 1:00 to 2:00 0 0 0 2 4 2 0 16.8 2:00 to 3:00 0 0 0 1 2 0 0 7 3:00 to 4:00 0 0 0 0 7 2 0 23.8 4:00 to 5:00 0 3 0 7 4 7 0 30.3 5:00 to 6:00 0 6 0 11 8 7 0 47.8 6:00 to 7:00 0 9 2 18 14 12 0 83.3 7:00 to 8:00 0 12 4 24 21 16 0 119.4 8:00 to 9:00 1 17 7 28 33 23 0 174.7 9:00 to 10:00 2 22 9 32 35 26 1 194.9 10:00 to 11:00 0 28 12 34 38 33 2 223.2

JYOTI OM CHEMICAL RESEARCH CENTRE PVT. LTD. EIA REPORT OF M/s Manbro Polymers Limited, Plot No. D‐2/CH‐275,Industrial Estate, Dahej‐2, Dist. Bharuch, Gujarat.

TOWARDSACL 60

50 Bicycle 40 2Wheeler VEHICLE 30 Auto OF 20 Car

NO 10 Bus/Truck 0 LCV Others 11:0012:0013:0014:0015:oo16:0017:0018:0019:0020:0021:0022:0023:000:00 1:00 2:00 3:00 4:00 5:00 6:00 7:00 8:00 9:0010:00 to to to to to to to to to to to to to to to to to to to to to to to to 12:0013:0014:0015:0016:0017:0018:0019:0020:0021:0022:0023:0T0IM0E:001:002:003:004:005:006:007:008:009:0010:0011:00 The total one way traffic is 1633 during 24 hours. The column chart shows different types of vehicles passing towards ACL during every hour of day. Total No. Of bicycle: 8, 2 Wheeler: 380, Auto: 123, Car: 464, Truck/Bus:438, LCV:216 and Other vehicles:4 are passing from su rvey point towards ACL. TOWARDSGNFC 0.13% 0.88%

15.83% Bicycle 2 Wheeler 23.72% Auto Car 20.46% Bus/Truck 7.63% LCV Others

31.35%

The pie chart shows that various type and number of vehicle are travelling towards ACL. The details show that maximum cars are travelling towards ACL and minimum other vehicles are travelling during survey period.

JYOTI OM CHEMICAL RESEARCH CENTRE PVT. LTD. EIA REPORT OF M/s Manbro Polymers Limited, Plot No. D‐2/CH‐275,Industrial Estate, Dahej‐2, Dist. Bharuch, Gujarat.

PCU/Hour

300

200

100 PCU/Hour 0

The column chart shows values of Passenger Car Unit(PCU) for every hour.From the chart we can see that the value of Passenger Car Unit is minimum for 2:00 to 3:00 and maximum for 10:00 to11:00.

JYOTI OM CHEMICAL RESEARCH CENTRE PVT. LTD. 9/22/2018 SPECIAL CIVIL APPLICATION - No. 5312 of 2016

Status : PENDING ( Filing(Stamp) Number : SCA/5331/2016 ) CNR No : GJHC240461492016

Next Listing 27/11/2018 Date: Coram HONOURABLE THE CHIEF JUSTICE MR. R.SUBHASH REDDY and HONOURABLEANNEXURE-XIV MR.JUSTICE VIPUL M. PANCHOLI S.NO.Petitioner Name Advocate On Record 1 JAYESHKUMAR SOMABHAI PATEL ANSHUL N SHAH(8540) for: Petitioner(s) 1 - 12 2 CHANDRASHEKHAR BHANUPRASAD UPASANI MR NILESH P SHAH(3215) for: Petitioner(s) 1 - 12 3 MALAV PRAFULBHAI DALWADI 4 SNEHAL BHARATBHAI SATYAPATHI 5 PRADEEP PRABHAKAR JOSHI 6 GAURANG VINODBHAI PARMAR 7 DARSHAN JITENDRABHAI PAREKH 8 SURESH TULSHIBHAI MORADIA 9 SUDHIR NARAISINGH VERMA 10 SEEMA CHANDRAKANT ABHALE 11 DILIP CHANDUBHAI THAKKAR 12 BALU TRIBHOVAN PATEL S.NO.Respondent Name Advocate On Record 1 UNION OF INDIA NOTICE SERVED(4) for :Respondent(s) 1

Presented On : 30/03/2016 Registered On : 04/04/2016 Bench Category : DIVISION District : SURAT Case Originated From : - : Purpose of Listing : 192-NOTICE & ADJOURNED MATTERS Classification 2012-DB - VIRES CHALLENGED - VIRES CHALLENGED - CONSTITUTION OF INDIA - CENTRAL ACT / STATE ACT / RULE / STATUTORY NOTIFICATION / REGULATIONS

Act CONSTITUTION OF INDIA

Court Proceedings

S. Notified Board No. Date CourtCode Sr. No. Stage Action Coram

1 05/04/2016 1 6 111-URGENT ADMISSION (FRESH 4-FIXED NOTICE HONOURABLE THE CHIEF JUSTICE MR. MATTERS) R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

2 13/06/2016 1 31 192-NOTICE & ADJOURNED 1-NEXT DATE HONOURABLE THE CHIEF JUSTICE MR. MATTERS R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

3 04/07/2016 1 35 192-NOTICE & ADJOURNED 1-NEXT DATE HONOURABLE THE CHIEF JUSTICE MR. MATTERS R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

4 21/07/2016 1 55 192-NOTICE & ADJOURNED 1-NEXT DATE HONOURABLE THE CHIEF JUSTICE MR. MATTERS R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

5 22/08/2016 1 36 192-NOTICE & ADJOURNED 1-NEXT DATE HONOURABLE THE CHIEF JUSTICE MR. MATTERS R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

6 14/09/2016 1 119 192-NOTICE & ADJOURNED 1-NEXT DATE HONOURABLE THE CHIEF JUSTICE MR. MATTERS R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

7 05/10/2016 1 119 192-NOTICE & ADJOURNED 1-NEXT DATE HONOURABLE THE CHIEF JUSTICE MR. MATTERS R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

8 07/11/2016 1 29 192-NOTICE & ADJOURNED 1-NEXT DATE HONOURABLE THE CHIEF JUSTICE MR. MATTERS R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

1/4 9/22/2018

S. Notified Board No. Date CourtCode Sr. No. Stage Action Coram

9 18/11/2016 1 73 192-NOTICE & ADJOURNED 1-NEXT DATE HONOURABLE THE CHIEF JUSTICE MR. MATTERS R.SUBHASH REDDY ANNEXURE-XIVHONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

10 19/12/2016 1 88 192-NOTICE & ADJOURNED 1-NEXT DATE HONOURABLE THE CHIEF JUSTICE MR. MATTERS R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

11 20/01/2017 1 69 192-NOTICE & ADJOURNED 1-NEXT DATE HONOURABLE THE CHIEF JUSTICE MR. MATTERS R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

12 21/02/2017 1 50 192-NOTICE & ADJOURNED 1-NEXT DATE HONOURABLE THE CHIEF JUSTICE MR. MATTERS R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

13 14/03/2017 1 86 192-NOTICE & ADJOURNED 1-NEXT DATE HONOURABLE THE CHIEF JUSTICE MR. MATTERS R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

14 20/04/2017 1 109 192-NOTICE & ADJOURNED 1-NEXT DATE HONOURABLE THE CHIEF JUSTICE MR. MATTERS R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

15 03/07/2017 1 97 192-NOTICE & ADJOURNED 1-NEXT DATE HONOURABLE THE CHIEF JUSTICE MR. MATTERS R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

16 04/09/2017 1 86 192-NOTICE & ADJOURNED 1-NEXT DATE HONOURABLE THE CHIEF JUSTICE MR. MATTERS R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

17 14/11/2017 1 74 192-NOTICE & ADJOURNED 1-NEXT DATE HONOURABLE THE CHIEF JUSTICE MR. MATTERS R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

18 12/01/2018 1 49 192-NOTICE & ADJOURNED 1-NEXT DATE HONOURABLE THE CHIEF JUSTICE MR. MATTERS R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

19 20/02/2018 1 65 192-NOTICE & ADJOURNED 1-NEXT DATE HONOURABLE THE CHIEF JUSTICE MR. MATTERS R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

20 27/03/2018 1 120 192-NOTICE & ADJOURNED 1-NEXT DATE HONOURABLE THE CHIEF JUSTICE MR. MATTERS R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

21 27/03/2018 1 120 192-NOTICE & ADJOURNED HONOURABLE THE CHIEF JUSTICE MR. MATTERS R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

22 03/04/2018 1 140 192-NOTICE & ADJOURNED 1-NEXT DATE HONOURABLE THE CHIEF JUSTICE MR. MATTERS R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

2/4 9/22/2018

S. Notified Board No. Date CourtCode Sr. No. Stage Action Coram

23 13/04/2018 1 89 192-NOTICE & ADJOURNED 1-NEXT DATE HONOURABLE THE CHIEF JUSTICE MR. MATTERS R.SUBHASH REDDY ANNEXURE-XIVHONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

24 10/07/2018 1 219 192-NOTICE & ADJOURNED 1-NEXT DATE HONOURABLE THE CHIEF JUSTICE MR. MATTERS R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

25 07/09/2018 1 104 192-NOTICE & ADJOURNED 1-NEXT DATE HONOURABLE THE CHIEF JUSTICE MR. MATTERS R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

Available Orders

S. No. Case Details Judge Name Order Date CAV Judgement Questions Transferred Download

1 SCA/5312/2016 HONOURABLE THE CHIEF JUSTICE MR. 05/04/2016 N ORDER - Y Download R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

2 SCA/5312/2016 HONOURABLE THE CHIEF JUSTICE MR. 21/07/2016 N ORDER - Y Download R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

3 SCA/5312/2016 HONOURABLE THE CHIEF JUSTICE MR. 18/11/2016 N ORDER - Y Download R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

4 SCA/5312/2016 HONOURABLE THE CHIEF JUSTICE MR. 20/01/2017 N ORDER - Y Download R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

Connected Matters

S. No. CaseDetail Status Name Disposal Date Action/Coram

1 R/SCA/2702/2018 PENDING - HONOURABLE THE CHIEF JUSTICE MR. R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

2 R/SCA/4055/2018 PENDING - HONOURABLE THE CHIEF JUSTICE MR. R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

3 R/SCA/7669/2018 PENDING - HONOURABLE THE CHIEF JUSTICE MR. R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

4 R/SCA/11525/2018 PENDING - HONOURABLE THE CHIEF JUSTICE MR. R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

5 R/SCA/17039/2016 PENDING - HONOURABLE THE CHIEF JUSTICE MR. R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

6 R/SCA/11208/2017 PENDING - HONOURABLE THE CHIEF JUSTICE MR. R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

7 R/SCA/20606/2017 PENDING - HONOURABLE THE CHIEF JUSTICE MR. R.SUBHASH REDDY HONOURABLE MR.JUSTICE VIPUL M. PANCHOLI

Application / Appeal Matters NO DATA FOR APPLICATION / APPEAL MATTERS IA Details NO DATA FOR APPLICATIONS

3/4 9/22/2018

Office Details

Court Fee on S. No. Filing Date Document Name Advocate Name Document Document Details

1 30/03/2016 VAKALATNAMA ANSHUL N SHAH 0 -JAYESHKUMAR SOMABHAI ANNEXURE-XIVfor PETITIONER(s) PATEL

2 30/03/2016 MEMO OF MR NILESH P SHAH 100 -JAYESHKUMAR SOMABHAI PETITION/APPEAL/SUIT for PETITIONER(s) PATEL

3 30/03/2016 VAKALATNAMA MR NILESH P SHAH 5 -JAYESHKUMAR SOMABHAI for PETITIONER(s) PATEL

4 01/04/2016 ADDITIONAL FEE ON MEMO MR NILESH P SHAH 500 -JAYESHKUMAR SOMABHAI OF APPEAL/PETITION/SUIT for PETITIONER(s) PATEL

Certified Copy NO DATA FOR CERTIFIED COPY Lowercourt Detail NO DATA FOR LOWERCOURT DETAIL FIR Details NO DATA FOR FIR DETAILS

4/4 C/SCA/4729/2015 ORDER

ANNEXURE-XIVIN THE HIGH COURT OF GUJARAT AT AHMEDABAD

R/SPECIAL CIVIL APPLICATION NO. 4729 of 2015 With R/SPECIAL CIVIL APPLICATION NO. 10311 of 2012 With R/SPECIAL CIVIL APPLICATION NO. 12466 of 2013 With R/SPECIAL CIVIL APPLICATION NO. 13581 of 2013 With R/SPECIAL CIVIL APPLICATION NO. 1782 of 2013 With R/SPECIAL CIVIL APPLICATION NO. 4730 of 2015 With R/SPECIAL CIVIL APPLICATION NO. 4974 of 2012 With R/SPECIAL CIVIL APPLICATION NO. 4979 of 2012 With R/SPECIAL CIVIL APPLICATION NO. 6633 of 2014 With R/SPECIAL CIVIL APPLICATION NO. 8010 of 2015 With R/SPECIAL CIVIL APPLICATION NO. 9679 of 2013 With R/SPECIAL CIVIL APPLICATION NO. 9680 of 2013

KIRAN K POOJARI Versus UNION OF INDIA Appearance: MR NILESH P SHAH(3215) for PETITIONER(s) No. 1 MR KSHITIJ AMIN for MR DEVANG VYAS(2794) for RESPONDENT No. 1 MR BHASH H MANKAD(6258) for RESPONDENT(s) No. 2

CORAM: HONOURABLE MR.JUSTICE ANANT S. DAVE and HONOURABLE MR.JUSTICE A.C. RAO

Date : 29/10/2018

COMMON ORAL ORDER (PER : HONOURABLE MR.JUSTICE ANANT S. DAVE)

Page 1 of 2 C/SCA/4729/2015 ORDER

ANNEXURE-XIVHeard Mr. Nilesh Shah, learned counsel for the petitioners, Mr. Kshitij Amin, learned Standing Counsel for respondent No.1 and Mr. B.H.Mankad, learned counsel for respondent No.2.

Learned counsels for the respondent Nos.1 and 2 state that, as per their information, Office Memoranda dated 18.03.2010, 28.05.2010, 28.06.2010 and 30.06.2011 are not in force. It is also stated that notifications dated 03.03.2016 and 15.01.2016 issued later on are under challenge before this Court and various other High Courts in which interim orders are passed.

In view of the above, according to us, challenge to the subject Office Memoranda, as such will not survive. Accordingly, all these petitions stand disposed of. However, there shall be no order as to costs. Liberty is reserved to revive the petitions in case of any difficulty.

(ANANT S. DAVE, J)

(A. C. RAO, J) P. SUBRAHMANYAM

Page 2 of 2 February 1987 (edited October 1987) Chlorophenols

Guidelines weight compounds. The log octanol–water partition The maximum acceptable concentrations (MAC) coefficient increases with the number of chlorine and aesthetic objectives (AO) for four chlorophenols atoms from 2.15 for 2-CP to 5.0 for PCP.1,2 in drinking water are: Chlorophenols with few chlorine atoms are used mainly as starting materials for the synthesis of higher MAC AO chlorinated phenols or chlorophenol-derived products, mg/L mg/L mg/L mg/L such as the chlorophenoxyacetic acid herbicides. 2,4-dichlorophenol 0.9 900 £ 0.0003 £ 0.3 Chlorophenols are no longer manufactured in 2,4,6-trichlorophenol 0.005 5 £ 0.002 £ 2 Canada; however, they continue to be imported. They 2,3,4,6-tetrachlorophenol 0.1 100 £ 0.001 £ 1 are widely used in pesticides; currently, there are seven pentachlorophenol 0.06 60 £ 0.030 £ 30 chlorinated phenols incorporated into 110 pesticide products registered for use in Canada under the Pest Identity, Use and Sources in the Control Products Act.3 Both PCP and TeCPs are used Environment extensively as wood preservatives4 and account for the Chlorophenols are organic chemicals in which one majority of chlorophenols imported for use in Canada. or more hydrogen atoms of phenol (1-hydroxybenzene) In 1984, sales of chlorophenol-containing products are replaced by one or more atoms of chlorine. There (tonnes of active ingredient) registered under the Pest are 19 chlorophenol congeners: Control Products Act were as follows:5 2-chlorophenol (2-CP) 3-chlorophenol (3-CP) PCP and its sodium salt 3400 tonnes 4-chlorophenol (4-CP) TeCPs and their sodium salts 490 tonnes 2,4,5-TCP and its sodium salt < 1 tonne 2,3-dichlorophenol (2,3-DCP) 2,4-dichlorophenol (2,4-DCP) 2,5-dichlorophenol (2,5-DCP) Exposure 2,6-dichlorophenol (2,6-DCP) Chlorophenols may be introduced into water either 3,4-dichlorophenol (3,4-DCP) during their manufacture and use or through degradation 3,5-dichlorophenol (3,5-DCP) of other chemicals (e.g., phenoxyalkanoic acids). 2,3,4-trichlorophenol (2,3,4-TCP) Chlorophenols may also be formed as a result of the 2,3,5-trichlorophenol (2,3,5-TCP) chlorination of humic matter or of natural carboxylic 2,3,6-trichlorophenol (2,3,6-TCP) acids during the chlorination of municipal drinking 2,4,5-trichlorophenol (2,4,5-TCP) 3,4 2,4,6-trichlorophenol (2,4,6-TCP) water. Low solubility in water may be increased by 3,4,5-trichlorophenol (3,4,5-TCP) formation of the sodium or potassium salt congeners. 2,3,4,5-tetrachlorophenol (2,3,4,5-TeCP) Pentachlorophenol is the most persistent of the 2,3,4,6-tetrachlorophenol (2,3,4,6-TeCP) chlorophenols. 2,3,5,6-tetrachlorophenol (2,3,5,6-TeCP) Concentrations of chlorophenols in Canadian pentachlorophenol (PCP) surface waters rarely exceed 2 mg/L.3 Amounts of chlorophenols in drinking water have recently been All the chlorophenols are solids (melting points 33 determined at 40 potable water treatment plants across to 191°C) except 2-CP, which is a liquid with a melting Canada.6 Pentachlorophenol was found in more than point of 9°C. Most chlorophenols and all of their 20% of the samples of raw water taken in the fall and sodium salts are soluble in water. Solubility is slight winter, at concentrations up to 53 ng/L; mean for a few, including PCP (solubility 9.6 mg/L at 20°C). concentrations were 1.9 and 2.8 ng/L, respectively. The Vapour pressures are low for the higher molecular chlorinated phenols identified most frequently in treated

1 Chlorophenols (02/87)

water samples were 4-CP, 2,4-DCP and 2,4,6-TCP. experimental animals and to a lesser degree in the brain, Mean concentrations of 4-CP and 2,4-DCP were less muscle and fat.1 They are bound to glucuronide or than 10 ng/L, regardless of time of year of sampling. sulphate in the liver. 2,3,5,6-Tetrachlorophenol is Mean concentrations of 2,4,6-TCP were £40 ng/L. In metabolized to a more toxic substance, tetrachloro-p- Alberta, treated water from 29 municipal drinking water hydroquinone. Chlorophenols are eliminated primarily supplies was sampled for five chlorophenols (2-CP, in the urine in both free and bound forms, with lesser 2,4-DCP, 2,4,5-TCP, 2,4,6-TCP and PCP) for two to amounts in faecal matter. Four human volunteers who four years. 2,4,6-Trichlorophenol was detected in 12 ingested PCP at a concentration of 0.1 mg/kg bw of 29 supplies at concentrations ranging from a trace eliminated 74 and 12% of the administered dose as PCP to 3 mg/L. Pentachlorophenol was detected in two of and PCP-glucuronide, respectively, in their urine within 9 29 supplies at the detection limit (1 mg/L).7 eight days. Another 4% was eliminated in the faeces. Low concentrations (<0.01 mg/kg) of TeCPs and The toxic effects of chlorophenols are directly 3 PCP have been detected in Canadian foods.3 Higher proportional to the degree of chlorination. Acute concentrations have been found, however, in products exposure to lesser chlorinated phenols in humans results derived from animals exposed to PCP-contaminated in muscular twitching, spasms, tremors, weakness, wood and wood shavings and in some vegetables stored ataxia, convulsions and collapse. Acute poisoning by in PCP-treated wooden bins. There is a paucity of data PCP is characterized by general weakness, fatigue, concerning levels of chlorophenols in air in Canada. Air ataxia, headache, anorexia, sweating, hyperpyrexia, in PCP-treated homes can contain PCP at concentrations nausea, vomiting, tachycardia, abdominal pain, terminal as high as 1 mg/m3.3 spasms and death. In man, the minimum lethal oral dose Other sources of human exposure to chlorophenols of PCP has been estimated to be 29 mg/kg bw. include disinfectants, photographic solutions, fabrics Soft-tissue sarcomas, Hodgkin’s disease and and pharmaceuticals.3 Treated wood containing PCP leukaemia have been reported in epidemiological studies and TeCPs may also contribute to exposure. of occupational groups exposed to chlorinated phenols Total exposure of adult Canadians to chlorophenols and phenoxy acids. The World Health Organization examined data for 2,4,5-TCP, 2,4,6-TCP and PCP and has been estimated to be approximately 15 mg/d;3 the concluded that, at the time of review, the data were percent contribution of each route of exposure is as inadequate for an evaluation of carcinogenicity.10 follows: Slight changes in liver histopathology were reported food 40% in male mice following six months of exposure to water 19% 2,4-DCP at 230 mg/kg bw per day in their diet.11 The indoor and ambient air 28% miscellaneous 13% authors concluded that the no-observed-adverse-effect level (NOAEL) was 100 mg/kg bw per day. The study Analytical Methods and Treatment was, however, limited, and the published report was Technology incomplete: only one sex was used; the period of administration ranged from five to six months; and only Chlorophenols in water may be analysed by seven of the 10 animals in each group were examined. derivatization followed by gas chromatography and Lower chlorinated phenols were tested for mass spectrometry or electron capture detection. The carcinogenicity by Boutwell and Bosch.12 Site-specific practical quantitation limits (PQL) (based on the ability papillomas were observed when solutions of 2-CP or of laboratories to measure chlorophenols within 2,4-DCP were applied to the skin of mice without the reasonable limits of precision and accuracy) range 6 addition of any tumour initiators. When the initiator from 0.002 to 0.008 mg/L. 9,10-dimethyl-1,2-benzanthracene (DMBA) was used, Available data indicate that concentrations of carcinomas were observed at the treatment site in some 2,4,6-TCP and other chlorophenols are not reduced mice. These data are, however, inadequate for a proper significantly during conventional drinking water assessment of the carcinogenicity of these chlorophenols. treatment processes. Although few relevant data are In a National Cancer Institute bioassay, 50 male and available, it is likely that concentrations below 1 mg/L 50 female rats were administered either 5000 or can commonly be achieved by packed tower aeration 10 000 ppm 2,4,6-TCP (96 to 97% pure) in their diet for 8 and granular activated carbon adsorption. 106 or 107 weeks.13 Fifty male mice were administered either 5000 or 10 000 ppm for 105 weeks. Fifty female Health Effects mice were initially given 10 000 or 20 000 ppm for Chlorophenols are readily absorbed when 38 weeks, followed by 2500 or 5000 ppm for 67 weeks. administered by the oral, inhalation or dermal routes.1,2 2,4,6-Trichlorophenol was carcinogenic to male rats, They accumulate mostly in the liver and kidney of inducing lymphomas or leukaemias, and carcinogenic to

2 Chlorophenols (02/87)

mice of both sexes, inducing hepatocellular carcinomas compound was 90% PCP and 10% TeCPs. Trichloro- or adenomas. The test compound was 96 to 97% pure, phenols and non-phenolics were present in small containing up to 17 minor contaminants. Chlorinated quantities. dibenzo-p-dioxin content was not determined. The carcinogenicity of PCP has been investigated Classification and Assessment in two chronic studies. Two hybrid strains of mice were 2,4-Dichlorophenol: The data available are exposed to PCP at 46.4 mg/kg bw per day, by gavage for considered to be inadequate to classify 2,4-DCP with three weeks, followed by exposure to 130 ppm in the respect to its potential carcinogenicity. It has, therefore, diet for 74 weeks.14 There were no significant increases been included in Group VA (inadequate data for in tumour incidence in male or female mice of either evaluation). strain. For compounds classified in Group VA, the In a second chronic bioassay of PCP, male and maximum acceptable concentration (MAC) is derived female rats were administered PCP in the diet for 22 to on the basis of division of the NOAEL or lowest- 24 months, at concentrations of 0, 1, 3, 10 or 30 mg/kg observed-adverse-effect level (LOAEL) in an animal bw per day.15 Clinical examination revealed effects at species by an uncertainty factor. For 2,4-DCP, the the highest dose level, including decreased body weight acceptable daily intake (ADI) is derived as follows: 100 mg/kg bw per day gain in females, increased serum glutamic pyruvic ADI = = 0.1 mg/kg bw per day transaminase activity in both males and females and 1000 increased specific gravity of urine in females. where: Histological examination indicated an accumulation · 100 mg/kg bw per day is the NOAEL observed in the only available 11 of pigment in the liver and kidney of female rats treated subchronic (six months) feeding study, which suffered from methodological limitations with 30 and 10 mg/kg bw per day and of male rats · 1000 is the uncertainty factor (×10 for less-than-lifetime study and treated with 30 mg/kg bw per day. Ingestion of 3 mg/kg limitations in study design; ×10 for intraspecies variation; and ×10 bw per day or less by females and 10 mg/kg bw per day for interspecies variation). by males was not associated with significant toxicological effects. It should be noted that group size was 2,4,6-Trichlorophenol: 2,4,6-Trichlorophenol is limited to 27 rats and that there was high mortality in classified in Group II — probably carcinogenic to man both control and exposed males. It was determined that (inadequate evidence in humans, sufficient evidence in the test compound was composed of 90% PCP, 10% animals); it has been shown to be carcinogenic to male 13 TeCPs and small amounts of TCPs and non-phenolics. rats and mice of both sexes. Incorporating a surface Pentachlorophenol does not appear to be a potent area correction and using the robust linear extrapolation mutagen. It probably does not cause point mutations model, one can calculate that the unit lifetime risk and does not seem to cause chromosomal aberrations. associated with the ingestion of 1 mg/L 2,4,6-TCP However, PCP has been demonstrated to increase in drinking water ranges from 1.8 × 10-8 (based on mitotic gene conversion.2 hepatocellular carcinomas in female mice) to 4.3 × 10-7 18 Chlorophenols are not considered to be teratogenic, (based on leukaemia in male rats)*. The estimated although animal studies indicate that PCP and TeCPs ranges of concentrations in drinking water can be embryotoxic.16,17 Delayed ossification of the corresponding to lifetime risks of 10-5, 10-6 and 10-7 for skull bones was observed in rat foetuses of dams fed these same tumour types based on the model described 30 mg/kg bw per day of 2,3,4,6-TeCP (99.6% pure) in above are as follows: 16 corn oil by gavage during days 6 to 15 of gestation. Concentrations in A NOAEL of 10 mg/kg bw per day was proposed by the Lifetime risk drinking water (mg/L) authors for embryotoxicity. In a similar study with PCP, 10-5 23 – 555.6 delayed ossification was observed at the lowest dose 10-6 2.3 – 55.6 level tested (5 mg/kg bw per day).17 10-7 0.23 – 5.6 Pentachlorophenol caused a reduction in mean 2,3,4,6-Tetrachlorophenol: The available data are adult body weight when administered to female rats at inadequate to classify 2,3,4,6-TeCP with respect to its 30 mg/kg bw per day prior to mating, during mating and potential carcinogenicity. It is therefore classified in gestation and throughout lactation.15 There was also a Group VA (inadequate data for evaluation). The ADI is significant decrease in neonatal survival and growth derived as follows: among litters of females in this group. Ingestion of 10 mg/kg bw per day 3 mg/kg bw per day had no effect on reproduction, ADI = = 0.01 mg/kg bw per day neonatal growth, survival or development. The test 1000

*Average adult body weight = 70 kg; average daily intake of drinking water = 1.5 L.

3 Chlorophenols (02/87)

where: 2,4,6-Trichlorophenol: Because 2,4,6-TCP is · 10 mg/kg bw per day is the NOAEL for embryotoxicity observed in classified in Group II (probably carcinogenic to man), 16 a short-term study the MAC is derived based on consideration of available · 1000 is the uncertainty factor (×10 for intraspecies variation; ×10 for practicable treatment technology and estimated lifetime interspecies variation; and ×10 for use of short-term bioassay data). cancer risks. Because the MAC must also be measurable by available analytical methods, the PQL is also taken Pentachlorophenol: The available epidemiological into consideration in its derivation. data and results of studies in experimental animals are inadequate to classify PCP with respect to its potential An MAC of 0.005 mg/L (5 mg/L) for 2,4,6-TCP carcinogenicity. It is therefore included in Group VA was established, therefore, on the basis of the following (inadequate data for evaluation). The ADI is derived as considerations: follows: (1) The estimated maximum unit lifetime cancer risk associated with the ingestion of 1 mg/L 2,4,6-TCP 3 mg/kg bw per day ADI = = 0.006 mg/kg bw per day in drinking water is 4.3 × 10-7 (based on leukaemias 500 in male rats). Therefore, the estimated lifetime risk where: associated with the ingestion of drinking water con- · 3 mg/kg bw per day is the NOAEL reported in both a subchronic -6 reproductive study and a limited chronic study15 taining 5 mg/L 2,4,6-TCP (i.e., 2.2 × 10 ) is within a range that is considered to be “essentially negligible.” · 500 is the uncertainty factor (×10 for intraspecies variation; ×10 for interspecies variation; and ×5 for limitations of the chronic study). (2) Although it is unlikely that 2,4,6-TCP concentrations are reduced significantly during conventional Aesthetic Considerations drinking water treatment processes, limited data avail- Threshold odour values (TOV) for some able indicate that concentrations in Canadian drinking chlorophenols are shown below: water supplies are generally considerably less than 5 mg/L. Although few relevant data are available, it is Substance TOV (mg/L) Reference likely that concentrations of 2,4,6-TCP below 1 mg/L 2-CP 0.1 19 can be achieved by packed tower aeration and granular 3-CP 0.1 20 activated carbon adsorption. 4-CP 0.1 20 (3) The PQL (based on the ability of laboratories to 2,3-DCP 0.04 20 measure 2,4,6-TCP within reasonable limits of precision 2,4-DCP 0.3 21 2,5-DCP 0.5 20 and accuracy) is 0.008 mg/L. 2,6-DCP 0.2 20 Based on the threshold odour value, the aesthetic 3,4-DCP 0.3 20 objective (AO) for 2,4,6-TCP is £0.002 mg/L. 2,4,5-TCP 1.0 20 2,4,6-TCP 2.0 20 2,3,4,6-Tetrachlorophenol: Because 2,3,4,6-TeCP 2,3,4,6,-TeCP 1.0 20 is classified in Group VA (inadequate data for evaluation), the MAC is derived from the ADI as PCP 30 22 follows:

0.01 mg/kg bw per day × 70 kg × 0.20 Rationale MAC = @ 0.100 mg/L 2,4-Dichlorophenol: Because 2,4-DCP is classified 1.5 L/d in Group VA (inadequate data for evaluation), the MAC where: is derived from the ADI as follows: · 0.01 mg/kg bw per day is the ADI, as derived above · 70 kg is the average body weight of an adult 0.1 mg/kg bw per day × 70 kg × 0.20 MAC = @ 0.9 mg/L · 0.20 is the proportion of total daily intake ingested in drinking water 1.5 L/d · 1.5 L/d is the average daily consumption of drinking water for an where: adult. · 0.1 mg/kg bw per day is the ADI, as derived above · 70 kg is the average body weight of an adult Based on the threshold odour value, the aesthetic · 0.20 is the proportion of total daily intake ingested in drinking water objective (AO) for 2,3,4,6-TeCP is £0.001 mg/L. · 1.5 L/d is the average daily consumption of drinking water for an adult. Pentachlorophenol: Because pentachlorophenol is classified in Group VA (inadequate data for evaluation), Based on the threshold odour value, the aesthetic the MAC is derived from the ADI as follows: objective (AO) for 2,4-DCB is £0.0003 mg/L. 0.006 mg/kg bw per day × 70 kg × 0.20 MAC = @ 0.06 mg/L 1.5 L/d

4 Chlorophenols (02/87)

where: 14. Innes, J.R.M., Ulland, B.M., Valerio, M.G., Petrucelli, L., · 0.006 mg/kg bw per day is the ADI, as derived above Fishbein, L., Hart, E.R., Pallotta, A.J., Bates, R.R., Falk, H.L., Gart, J.J., Klein, M., Mitchell, I. and Peters, J. Bioassay of pesticides · 70 kg is the average body weight of an adult and industrial chemicals for tumorigenicity in mice: a preliminary · 0.20 is the proportion of total daily intake ingested in drinking water note. J. Natl. Cancer Inst., 42(6): 1101 (1969). · 1.5 L/d is the average daily consumption of drinking water for an 15. Schwetz, B.A., Quast, J.F., Keeler, P.A., Humiston, C.G. and adult. Kociba, R.J. Results of two-year toxicity and reproduction studies on pentachlorophenol in rats. In: Pentachlorophenol: chemistry, Based on the threshold odour value, the aesthetic pharmacology and environmental toxicology. K. Rao (ed.). Plenum Press, New York, NY. pp. 301–309 (1978). objective (AO) for PCP is £0.030 mg/L. 16. Schwetz, B.A., Keeler, P.A. and Gehring, P.J. Effect of purified Other chlorophenols: There are no data available and commercial grade tetrachlorophenol on rat embryonal and fetal development. Toxicol. Appl. Pharmacol., 28(1): 146 (1974). to serve as a basis for establishing MACs for the other chlorophenols. 17. Schwetz, B.A., Keeler, P.A. and Gehring, P.J. The effect of purified and commercial grade pentachlorophenol on rat embryonal and fetal development. Toxicol. Appl. Pharmacol., 28(1): 151 (1974). References 18. Murdoch, D. Risk assessments—drinking water—revision. Memorandum to V. Armstrong, Monitoring and Criteria Division, 1. World Health Organization. Environmental health criteria for Department of National Health and Welfare, November 17 (1986). chlorophenols other than pentachlorophenol. Supplement. Draft, July 31 (1986). 19. U.S. Environmental Protection Agency. Ambient water quality criteria for 2-chlorophenol. EPA-440/5-80-034, NTIS Publ. No. 2. World Health Organization. Environmental health criteria for PB81-117459, Office of Water Regulations and Standards (1980). pentachlorophenol. Draft, March 19 (1986). 20. U.S. Environmental Protection Agency. Ambient water quality 3. Department of National Health and Welfare. Chlorophenols and criteria for chlorinated phenols. EPA-440/5-80-032, NTIS Publ. No. their impurities: a health hazard evaluation. Draft report, Bureau of PB81-117434, Office of Water Regulations and Standards (1980). Chemical Hazards (1986). 21. U.S. Environmental Protection Agency. Ambient water quality 4. Exon, J.H. A review of chlorinated phenols. Vet. Hum. Toxicol., criteria for 2,4-dichlorophenol. EPA-440/5-80-042, NTIS Publ. No. 26(6): 508 (1984). PB81-117533, Office of Water Regulations and Standards (1980). 5. Environment Canada. Dioxin-containing chemicals: sales and 22. U.S. Environmental Protection Agency. Ambient water quality imports. Commercial Chemicals Branch (1985). criteria for pentachlorophenol. EPA-440/5-80-065, NTIS Publ. No. 6. Sithole, B.B. and Williams, D.T. Halogenated phenols in water at PB81-117764, Office of Water Regulations and Standards (1980). forty Canadian potable water treatment facilities. J. Assoc. Off. Anal. Chem., 69(5): 807 (1986). 7. Alberta Environment. Drinking water survey 1978–1985. Municipal Engineering Branch, Pollution Control Division, Edmonton (1985). 8. McDonald, R.A. Water treatment technology review—control of chemical contaminants. Contractor’s report for Department of National Health and Welfare, M.R.2, McDonald and Associates, Regina (1985).

9. Braun, W.H., Blau, G.E. and Chenoweth, M.B. The metabolism/ pharmacokinetics of pentachlorophenol in man, and a comparison with the rat and a monkey model. Toxicol. Appl. Pharmacol., 45(1): 278 (1978). 10. World Health Organization. Guidelines for drinking-water quality. Vol. 2. Health criteria and other supporting information. Geneva (1984). 11. Kobayashi, S., Toida, S., Kawamura, H., Chang, H.S., Fukuda, T. and Kawaguchi, K. Chronic toxicity of 2,4-dichlorophenol in mice: a simple design for the toxicity of residual metabolites of pesticides. J. Med. Soc. Toho (Japan), 19(3–4): 356 (1972). 12. Boutwell, R.K. and Bosch, D.K. The tumor-promoting action of phenol and related compounds for mouse skin. Cancer Res., 19: 413 (1959). 13. National Cancer Institute. Bioassay of 2,4,6-trichlorophenol for possible carcinogenicity. Tech. Rep. Ser. No. 155, DHEW Publ. No. (NIH) 79-1711, U.S. Department of Health, Education and Welfare (1979).

5 SAFETY DATA SHEET

Revision Date 23-Jan-2018 Revision Number 3

1. Identification Product Name 5-Chloro-8-hydroxyquinoline

Cat No. : AC109300000; AC109300050; AC109301000; AC109305000

CAS-No 130-16-5 Synonyms 5-Chloro-8-quinolinol

Recommended Use Laboratory chemicals. Uses advised against Not for food, drug, pesticide or biocidal product use

Details of the supplier of the safety data sheet

Company Fisher Scientific Acros Organics One Reagent Lane One Reagent Lane Fair Lawn, NJ 07410 Fair Lawn, NJ 07410 Tel: (201) 796-7100

Emergency Telephone Number For information US call: 001-800-ACROS-01 / Europe call: +32 14 57 52 11 Emergency Number US:001-201-796-7100 / Europe: +32 14 57 52 99 CHEMTREC Tel. No.US:001-800-424-9300 / Europe:001-703-527-3887

2. Hazard(s) identification Classification This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)

Skin Corrosion/irritation Category 2 Serious Eye Damage/Eye Irritation Category 2 Specific target organ toxicity (single exposure) Category 3 Target Organs - Respiratory system.

Label Elements

Signal Word Warning

Hazard Statements Causes skin irritation Causes serious eye irritation May cause respiratory irritation

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Precautionary Statements Prevention Wash face, hands and any exposed skin thoroughly after handling Wear protective gloves/protective clothing/eye protection/face protection Avoid breathing dust/fume/gas/mist/vapors/spray Use only outdoors or in a well-ventilated area Inhalation IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing Call a POISON CENTER or doctor/physician if you feel unwell Skin IF ON SKIN: Wash with plenty of soap and water If skin irritation occurs: Get medical advice/attention Take off contaminated clothing and wash before reuse Eyes IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing If eye irritation persists: Get medical advice/attention Storage Store in a well-ventilated place. Keep container tightly closed Store locked up Disposal Dispose of contents/container to an approved waste disposal plant Hazards not otherwise classified (HNOC) None identified

3. Composition/Information on Ingredients

Component CAS-No Weight % 8-Quinolinol, 5-chloro- 130-16-5 95

4. First-aid measures

Eye Contact Immediate medical attention is required. Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.

Skin Contact Wash off immediately with soap and plenty of water while removing all contaminated clothes and shoes. Obtain medical attention. Take off contaminated clothing and shoes immediately.

Inhalation Remove from exposure, lie down. Move to fresh air. If not breathing, give artificial respiration. Immediate medical attention is required.

Ingestion Never give anything by mouth to an unconscious person. Drink plenty of water. Call a physician immediately. If possible drink milk afterwards.

Most important symptoms and No information available. effects Notes to Physician Treat symptomatically

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5. Fire-fighting measures Suitable Extinguishing Media Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.

Unsuitable Extinguishing Media No information available

Flash Point No information available Method - No information available

Autoignition Temperature Explosion Limits Upper No data available Lower No data available Sensitivity to Mechanical Impact No information available Sensitivity to Static Discharge No information available

Specific Hazards Arising from the Chemical Keep product and empty container away from heat and sources of ignition.

Hazardous Combustion Products Thermal decomposition can lead to release of irritating gases and vapors Protective Equipment and Precautions for Firefighters As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear. Thermal decomposition can lead to release of irritating gases and vapors.

NFPA Health Flammability Instability Physical hazards 2 1 0 N/A

6. Accidental release measures Personal Precautions Ensure adequate ventilation. Use personal protective equipment. Environmental Precautions See Section 12 for additional ecological information.

Methods for Containment and Clean Sweep up or vacuum up spillage and collect in suitable container for disposal. Up

7. Handling and storage Handling Avoid contact with skin and eyes. Avoid contact with clothing. Remove and wash contaminated clothing before re-use. Avoid breathing vapors or mists. Do not ingest. Wash thoroughly after handling.

Storage Keep in a dry, cool and well-ventilated place. Keep container tightly closed.

8. Exposure controls / personal protection Exposure Guidelines This product does not contain any hazardous materials with occupational exposure limitsestablished by the region specific regulatory bodies.

Engineering Measures Ventilation systems. Ensure that eyewash stations and safety showers are close to the workstation location.

Personal Protective Equipment

Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.

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Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure.

Respiratory Protection No protective equipment is needed under normal use conditions.

Hygiene Measures Handle in accordance with good industrial hygiene and safety practice.

9. Physical and chemical properties Physical State Powder Solid Appearance Light green Odor Odorless Odor Threshold No information available pH No information available Melting Point/Range 121 - 126 °C / 249.8 - 258.8 °F Boiling Point/Range No information available Flash Point No information available Evaporation Rate Not applicable Flammability (solid,gas) No information available Flammability or explosive limits Upper No data available Lower No data available Vapor Pressure No information available Vapor Density Not applicable Specific Gravity No information available Solubility No information available Partition coefficient; n-octanol/water No data available Autoignition Temperature Decomposition Temperature No information available Viscosity Not applicable Molecular Formula C9 H6 Cl N O Molecular Weight 179.61

10. Stability and reactivity

Reactive Hazard None known, based on information available

Stability Stable under normal conditions.

Conditions to Avoid Incompatible products.

Incompatible Materials Oxidizing agents

Hazardous Decomposition Products Thermal decomposition can lead to release of irritating gases and vapors

Hazardous Polymerization Hazardous polymerization does not occur.

Hazardous Reactions None under normal processing.

11. Toxicological information Acute Toxicity

Product Information No acute toxicity information is available for this product Component Information Toxicologically Synergistic No information available Products Delayed and immediate effects as well as chronic effects from short and long-term exposure

Irritation No information available

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Sensitization No information available

Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen.

Component CAS-No IARC NTP ACGIH OSHA Mexico 8-Quinolinol, 5-chloro- 130-16-5 Not listed Not listed Not listed Not listed Not listed Mutagenic Effects No information available

Reproductive Effects No information available.

Developmental Effects No information available.

Teratogenicity No information available.

STOT - single exposure Respiratory system STOT - repeated exposure None known

Aspiration hazard No information available

Symptoms / effects,both acute and No information available delayed

Endocrine Disruptor Information No information available

Other Adverse Effects The toxicological properties have not been fully investigated.

12. Ecological information Ecotoxicity Do not empty into drains.

Persistence and Degradability No information available

Bioaccumulation/ Accumulation No information available.

Mobility No information available.

13. Disposal considerations Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. Chemical waste generators must also consult local, regional, and national hazardous waste regulations to ensure complete and accurate classification.

14. Transport information DOT Not regulated TDG Not regulated IATA Not regulated IMDG/IMO Not regulated 15. Regulatory information

International Inventories

Component TSCA DSL NDSL EINECS ELINCS NLP PICCS ENCS AICS IECSC KECL 8-Quinolinol, 5-chloro- X - X 204-978-1 - X X - X X Legend: X - Listed E - Indicates a substance that is the subject of a Section 5(e) Consent order under TSCA. F - Indicates a substance that is the subject of a Section 5(f) Rule under TSCA. N - Indicates a polymeric substance containing no free-radical initiator in its inventory name but is considered to cover the designated polymer made with any free-radical initiator regardless of the amount used. P - Indicates a commenced PMN substance

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R - Indicates a substance that is the subject of a Section 6 risk management rule under TSCA. S - Indicates a substance that is identified in a proposed or final Significant New Use Rule T - Indicates a substance that is the subject of a Section 4 test rule under TSCA. XU - Indicates a substance exempt from reporting under the Inventory Update Rule, i.e. Partial Updating of the TSCA Inventory Data Base Production and Site Reports (40 CFR 710(B). Y1 - Indicates an exempt polymer that has a number-average molecular weight of 1,000 or greater. Y2 - Indicates an exempt polymer that is a polyester and is made only from reactants included in a specified list of low concern reactants that comprises one of the eligibility criteria for the exemption rule.

U.S. Federal Regulations

TSCA 12(b) Not applicable

SARA 313 Not applicable

SARA 311/312 Hazard Categories See section 2 for more information

CWA (Clean Water Act) Not applicable

Clean Air Act Not applicable

OSHA Occupational Safety and Health Administration Not applicable

CERCLA Not applicable

California Proposition 65 This product does not contain any Proposition 65 chemicals

U.S. State Right-to-Know Not applicable Regulations

U.S. Department of Transportation

Reportable Quantity (RQ): N DOT Marine Pollutant N DOT Severe Marine Pollutant N

U.S. Department of Homeland Security This product does not contain any DHS chemicals.

Other International Regulations

Mexico - Grade No information available

16. Other information Prepared By Regulatory Affairs Thermo Fisher Scientific Email: [email protected]

Revision Date 23-Jan-2018 Print Date 23-Jan-2018 Revision Summary This document has been updated to comply with the US OSHA HazCom 2012 Standard replacing the current legislation under 29 CFR 1910.1200 to align with the Globally Harmonized System of Classification and Labeling of Chemicals (GHS).

Disclaimer The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text

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End of SDS

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Page 7 / 7 He a lt h 2 1 Fire 1 2 0 Re a c t iv it y 0 Pe rs o n a l Pro t e c t io n E Material Safety Data Sheet 8-Hydroxyquinoline MSDS

Section 1: Chemical Product and Company Identification

Product Name: 8-Hydroxyquinoline Contact Information: Catalog Codes: SLH2098 Sciencelab.com, Inc. 14025 Smith Rd. CAS#: 148-24-3 Houston, Texas 77396 RTECS: VC4200000 US Sales: 1-800-901-7247 International Sales: 1-281-441-4400 TSCA: TSCA 8(b) inventory: 8-Hydroxyquinoline Order Online: ScienceLab.com CI#: Not available. CHEMTREC (24HR Emergency Telephone), call: Synonym: Oxine; 8-Hydroxyquinoline 1-800-424-9300 Chemical Name: 8-Quinolinol International CHEMTREC, call: 1-703-527-3887 Chemical Formula: C9H7NO For non-emergency assistance, call: 1-281-441-4400

Section 2: Composition and Information on Ingredients

Composition:

Name CAS # % by Weight {8-}Hydroxyquinoline 148-24-3 100

Toxicological Data on Ingredients: 8-Hydroxyquinoline: ORAL (LD50): Acute: 1200 mg/kg [Rat]. 20000 mg/kg [Mouse]. DUST (LC50): Acute: >1210 mg/m 6 hours [Rat].

Section 3: Hazards Identification

Potential Acute Health Effects: Hazardous in case of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant, permeator), of eye contact (irritant). Potential Chronic Health Effects: CARCINOGENIC EFFECTS: 3 (Not classifiable for human.) by IARC. MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance may be toxic to central nervous system (CNS). Repeated or prolonged exposure to the substance can produce target organs damage.

Section 4: First Aid Measures

p. 1 Eye Contact: Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention if irritation occurs. Skin Contact: Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Serious Skin Contact: Not available. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Serious Inhalation: Not available. Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: May be combustible at high temperature. Auto-Ignition Temperature: Not available. Flash Points: Not available. Flammable Limits: Not available. Products of Combustion: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...). Fire Hazards in Presence of Various Substances: Slightly flammable to flammable in presence of open flames and sparks, of heat. Non-flammable in presence of shocks. Explosion Hazards in Presence of Various Substances: Risks of explosion of the product in presence of mechanical impact: Not available. Slightly explosive in presence of open flames and sparks. Fire Fighting Media and Instructions: SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet. Special Remarks on Fire Hazards: When heated to decomposition it emits highly toxic fumes. Special Remarks on Explosion Hazards: Fine dust dispersed in air in sufficient concentrations, and in presence of an ignition source, is a potential dust explosion hazard.

Section 6: Accidental Release Measures

Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Large Spill: Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system.

Section 7: Handling and Storage

p. 2 Precautions: Keep locked up.. Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Keep away from incompatibles such as oxidizing agents, acids. Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area. Sensitive to light. Store in light-resistant containers.

Section 8: Exposure Controls/Personal Protection

Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal Protection: Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure Limits: Not available.

Section 9: Physical and Chemical Properties

Physical state and appearance: Solid. (Solid crystalline powder.) Odor: Phenolic Taste: Not available. Molecular Weight: 145.16 g/mole Color: White. pH (1% soln/water): Not applicable. Boiling Point: 267°C (512.6°F) Melting Point: 74°C (165.2°F) Critical Temperature: Not available. Specific Gravity: 1.04 (Water = 1) Vapor Pressure: Not applicable. Vapor Density: Not available. Volatility: Not available. Odor Threshold: Not available. Water/Oil Dist. Coeff.: Not available. Ionicity (in Water): Not available. Dispersion Properties: See solubility in water, acetone. Solubility:

p. 3 Easily soluble in acetone. Insoluble in cold water, hot water. Freely soluble in alcohol, benzene, chloroform, and aqueous mineral acids. Soluble in acetic, formic, hydrochloric, and sulfuric acids, and in alkalies.

Section 10: Stability and Reactivity Data

Stability: The product is stable. Instability Temperature: Not available. Conditions of Instability: Excess heat, incompatible materials, excess dust generation, light Incompatibility with various substances: Reactive with oxidizing agents, acids. Corrosivity: Non-corrosive in presence of glass. Special Remarks on Reactivity: Sensitive to light. It darkens when exposed to light. Special Remarks on Corrosivity: Not available. Polymerization: Will not occur.

Section 11: Toxicological Information

Routes of Entry: Inhalation. Ingestion. Toxicity to Animals: WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oral toxicity (LD50): 1200 mg/kg [Rat]. Acute toxicity of the dust (LC50): >1210 mg/m3 6 hours [Rat]. Chronic Effects on Humans: CARCINOGENIC EFFECTS: 3 (Not classifiable for human.) by IARC. MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast. May cause damage to the following organs: central nervous system (CNS). Other Toxic Effects on Humans: Hazardous in case of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant, permeator). Special Remarks on Toxicity to Animals: Not available. Special Remarks on Chronic Effects on Humans: May affect genetic material (mutagenic). May cause cancer based on animal data. No human data found. Special Remarks on other Toxic Effects on Humans: Acute Potential Health Effects: Skin: Causes skin irritation. Eyes: Causes eye irritation. Inhalation: May be harmful if inhaled. Causes respiratory tract and mucous membrane irritation. Symptoms may include coughing, labored breathing, and chest pain. Other effects may parallel those of ingestion. Ingestion: May harmful if swallowed. May cause gastrointestinal tract irritation with nausea, vomiting and diarrhea. Ingestion of large oral doses may affect behavior/central nervous system (confusion, paralysis), respiration (breathing difficulty), metabolism (anorexia - weight loss or decreased weight gain), and may cause malaise. Chronic Potential Health Effects: Ingestion: Repeated or prolonged ingestion will also have effects similar to those of acute ingestion.

Section 12: Ecological Information

Ecotoxicity: Not available. BOD5 and COD: Not available. Products of Biodegradation: Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself. Special Remarks on the Products of Biodegradation: Not available.

p. 4 Section 13: Disposal Considerations

Waste Disposal: Waste must be disposed of in accordance with federal, state and local environmental control regulations.

Section 14: Transport Information

DOT Classification: Not a DOT controlled material (United States). Identification: Not applicable. Special Provisions for Transport: Not applicable.

Section 15: Other Regulatory Information

Federal and State Regulations: TSCA 8(b) inventory: 8-Hydroxyquinoline Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). Other Classifications: WHMIS (Canada): Not controlled under WHMIS (Canada). DSCL (EEC): R20/22- Harmful by inhalation and if swallowed. R36/37/38- Irritating to eyes, respiratory system and skin. R40- Possible risks of irreversible effects. S2- Keep out of the reach of children. S24/25- Avoid contact with skin and eyes. S46- If swallowed, seek medical advice immediately and show this container or label. HMIS (U.S.A.): Health Hazard: 2 Fire Hazard: 1 Reactivity: 0 Personal Protection: E National Fire Protection Association (U.S.A.): Health: 2 Flammability: 1 Reactivity: 0 Specific hazard: Protective Equipment: Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Safety glasses.

Section 16: Other Information

References: Not available. Other Special Considerations: Not available. Created: 10/10/2005 08:20 PM Last Updated: 05/21/2013 12:00 PM

p. 5 no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.com has been advised of the possibility of such damages.

p. 6 2,3-DICHLOROPHENOL MATERIAL SAFETY DATA SHEET CAS No 576-24-9 SDS/MSDS

SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1 Product identifiers Product name : 2,3-Dichlorophenol

CAS-No. : 576-24-9 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Industrial & for professional use only. 1.3 Details of the supplier of the safety data sheet Company : Central Drug House (P) Ltd 7/28 Vardaan House New Delhi -110002 INDIA Telephone : +91 11 49404040 Email : [email protected]

1.4 Emergency telephone number Emergency Phone # : +91 11 49404040 (9:00am - 6:00 pm) [Office hours]

SECTION 2: Hazards identification 2.1 Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 Skin irritation (Category 2), H315 Eye irritation (Category 2), H319 For the full text of the H-Statements mentioned in this Section, see Section 16. 2.2 Label elements Labelling according Regulation (EC) No 1272/2008

Pictogram

Signal word Warning Hazard statement(s) H315 Causes skin irritation. H319 Causes serious eye irritation. Precautionary statement(s) P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Page 1 of 7 Supplemental Hazard none Statements

2.3 Other hazards - none

SECTION 3: Composition/information on ingredients 3.1 Substances

Formula : C6H4Cl2O Molecular weight : 163.00 g/mol CAS-No. : 576-24-9 EC-No. : 209-399-8

Hazardous ingredients according to Regulation (EC) No 1272/2008 Component Classification Concentration 2,3-Dichlorophenol CAS-No. 576-24-9 Skin Irrit. 2; Eye Irrit. 2; H315, <= 100 % EC-No. 209-399-8 H319

For the full text of the H-Statements mentioned in this Section, see Section 16.

4.1 Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. 4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures 5.1 Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. 5.2 Special hazards arising from the substance or mixture Carbon oxides, Hydrogen chloride gas 5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary. 5.4 Further information No data available

Page 2 of 7 SECTION 6: Accidental release measures 6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Avoid breathing dust. For personal protection see section 8. 6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. 6.3 Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal. 6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage 7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire protection. For precautions see section 2.2. 7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible Solids 7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.

SECTION 8: Exposure controls/personal protection 8.1 Control parameters 8.2 Exposure controls Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Personal protective equipment Eye/face protection Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. Body Protection Impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Page 3 of 7 Respiratory protection For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle r (US) or type ABEK- P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

SECTION 9: Physical and chemical properties 9.1 Information on basic physical and chemical properties a) Appearance Form: crystalline Colour: light brown b) Odour No data available c) Odour Threshold No data available d) pH No data available e) Melting point/freezing Melting point/range: 55 - 57 °C - lit. point f) Initial boiling point and 206 °C - lit. boiling range g) Flash point 115 °C - closed cup h) Evaporation rate No data available i) Flammability (solid, gas) No data available j) Upper/lower No data available flammability or explosive limits k) Vapour pressure No data available l) Vapour density No data available m) Relative density No data available n) Water solubility No data available o) Partition coefficient: n- No data available octanol/water p) Auto-ignition No data available temperature q) Decomposition No data available temperature r) Viscosity No data available s) Explosive properties No data available t) Oxidizing properties No data available 9.2 Other safety information No data available

Page 4 of 7 SECTION 10: Stability and reactivity 10.1 Reactivity No data available 10.2 Chemical stability Stable under recommended storage conditions. 10.3 Possibility of hazardous reactions No data available 10.4 Conditions to avoid No data available 10.5 Incompatible materials Acid chlorides, Acid anhydrides, Oxidizing agents 10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Hydrogen chloride gas Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information 11.1 Information on toxicological effects Acute toxicity LD50 Oral - Mouse - 2,376 mg/kg(2,3-Dichlorophenol) Remarks: Behavioral:Tremor. Behavioral:Convulsions or effect on seizure threshold. Lungs, Thorax, or Respiration:Respiratory stimulation. Skin corrosion/irritation No data available(2,3-Dichlorophenol) Serious eye damage/eye irritation No data available(2,3-Dichlorophenol) Respiratory or skin sensitisation No data available(2,3-Dichlorophenol) Germ cell mutagenicity No data available(2,3-Dichlorophenol) Carcinogenicity IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity No data available(2,3-Dichlorophenol) Specific target organ toxicity - single exposure No data available(2,3-Dichlorophenol) Specific target organ toxicity - repeated exposure No data available Aspiration hazard No data available(2,3-Dichlorophenol)

Additional Information RTECS: SK8450000

Depending on the intensity and duration of exposure, effects may vary from mild irritation to severe destruction of tissue., prolonged or repeated exposure can cause:, Damage to the eyes., To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(2,3- Dichlorophenol) Page 5 of 7 SECTION 12: Ecological information 12.1 Toxicity Toxicity to fish LC50 - Oryzias latipes - 4 mg/l - 96 h(2,3-Dichlorophenol) Toxicity to daphnia and EC50 - Daphnia magna (Water flea) - 3.1 mg/l - 48 h(2,3-Dichlorophenol) other aquatic invertebrates 12.2 Persistence and degradability No data available 12.3 Bioaccumulative potential No data available 12.4 Mobility in soil No data available(2,3-Dichlorophenol) 12.5 Results of PBT and vPvB assessment PBT/vPvB assessment not available as chemical safety assessment not required/not conducted 12.6 Other adverse effects Toxic to aquatic life. No data available

SECTION 13: Disposal considerations 13.1 Waste treatment methods Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chem scrubber. Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information 14.1 UN number ADR/RID: 2020 IMDG: 2020 IATA: 2020 14.2 UN proper shipping name ADR/RID: CHLOROPHENOLS, SOLID IMDG: CHLOROPHENOLS, SOLID IATA: Chlorophenols, solid 14.3 Transport hazard class(es) ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1 14.4 Packaging group ADR/RID: III IMDG: III IATA: III 14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no 14.6 Special precautions for user No data available

Page 6 of 7 SECTION 15: Regulatory information 15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006. 15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information Full text of H-Statements referred to under sections 2 and 3. H315 Causes skin irritation. H319 Causes serious eye irritation.

Further information The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Central Drug House (P) Ltd and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.cdhfinechemical.com for additional terms and conditions of sale.

Page 7 of 7

SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006

Revision Date 05.11.2010 Version 4.5

1. Identification of the substance/mixture and of the company/undertaking 1.1 Product identifier Catalogue No. 820450 Product name 3,4-Dichlorophenol for synthesis REACH Registration Number A registration number is not available for this substance as the substance or its use are exempted from registration according to Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses Chemical for synthesis For additional information on uses please refer to the Merck Chemicals portal (www.merck-chemicals.com).

1.3 Details of the supplier of the safety data sheet Company Merck KGaA * 64271 Darmstadt * Germany * Phone:+49 6151 72-0 Responsible Department LS-QHC * e-mail: [email protected]

1.4 Emergency telephone Please contact the regional company representation in your country. number

2. Hazards identification 2.1 Classification of the substance or mixture Classification (REGULATION (EC) No 1272/2008) Skin irritation, Category 2, H315 Eye irritation, Category 2, H319 For the full text of the H-Statements mentioned in this Section, see Section 16.

Classification (67/548/EEC or 1999/45/EC) Xi; R36/38 N; R51/53 For the full text of the R-phrases mentioned in this Section, see Section 16.

2.2 Label elements Labelling (REGULATION (EC) No 1272/2008) Hazard pictograms

Signal word Warning

Hazard statements H315 Causes skin irritation.

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Catalogue No. 820450 Product name 3,4-Dichlorophenol for synthesis

H319 Causes serious eye irritation.

Precautionary statements P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Reduced labelling (≤125 ml) Hazard pictograms

Signal word Warning

CAS-No. 95-77-2

Labelling (67/548/EEC or 1999/45/EC) Symbol(s) Xi Irritant N Dangerous for the environment R-phrase(s) 36/38-51/53 Irritating to eyes and skin. Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. S-phrase(s) 26-61 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Avoid release to the environment. Refer to special instructions/ Safety data sheets. EC-No. 202-450-5 Reduced labelling (≤125 ml) Symbol(s) Xi Irritant N Dangerous for the environment

2.3 Other hazards None known.

3. Composition/information on ingredients Formula 3,4-(Cl)₂C₆H₃OH C₆H₄Cl₂O (Hill) CAS-No. 95-77-2 EC-No. 202-450-5 Molar mass 163 g/mol

4. First aid measures

4.1 Description of first aid measures After inhalation: fresh air.

After skin contact: wash off with plenty of water. Remove contaminated clothing.

After eye contact: rinse out with plenty of water. Call in ophthalmologist.

After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The Safety Data Sheets for catalogue items are available at www.merckgroup.com Page 2 of 9 SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006

Catalogue No. 820450 Product name 3,4-Dichlorophenol for synthesis

irritant effects, agitation, Convulsions The following applies to phenols in general: irritant or even caustic effect upon contact with skin or mucous membranes.

4.3 Indication of immediate medical attention and special treatment needed No information available.

5. Fire-fighting measures

5.1 Extinguishing media Suitable extinguishing media Water, Carbon dioxide (CO₂), Foam, Dry powder

Unsuitable extinguishing media For this substance/mixture no limitations of extinguishing agents are given.

5.2 Special hazards arising from the substance or mixture Combustible material Vapours are heavier than air and may spread along floors. Development of hazardous combustion gases or vapours possible in the event of fire. Fire may cause evolution of: Hydrogen chloride gas

5.3 Advice for firefighters Special protective equipment for fire-fighters Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

Further information Prevent fire extinguishing water from contaminating surface water or the ground water system. Suppress (knock down) gases/vapours/mists with a water spray jet.

6. Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Advice for non-emergency personnel: Avoid substance contact. Avoid inhalation of dusts. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.

Advice for emergency responders: Protective equipment see section 8.

6.2 Environmental precautions Do not empty into drains.

6.3 Methods and materials for containment and cleaning up Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7.2 and 10.5). Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts.

6.4 Reference to other sections Indications about waste treatment see section 13.

7. Handling and storage

7.1 Precautions for safe handling Observe label precautions.

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Catalogue No. 820450 Product name 3,4-Dichlorophenol for synthesis

7.2 Conditions for safe storage, including any incompatibilities Tightly closed. Dry.

Store at +15°C to +25°C.

7.3 Specific end uses Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.

8. Exposure controls/personal protection 8.1 Control parameters

8.2 Exposure controls Engineering measures Technical measures and appropriate working operations should be given priority over the use of personal protective equipment.

See section 7.1.

Individual protection measures Protective clothing needs to be selected specifically for the workplace, depending on concentrations and quantities of the hazardous substances handled. The chemical resistance of the protective equipment should be enquired at the respective supplier.

Hygiene measures Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

Eye/face protection Safety glasses

Hand protection full contact: Glove material: Nitrile rubber Glove thickness: 0,11 mm Break through time: > 480 min splash contact: Glove material: Nitrile rubber Glove thickness: 0,11 mm Break through time: > 480 min

The protective gloves to be used must comply with the specifications of EC Directive 89/686/EEC and the related standard EN374, for example KCL 741 Dermatril® L (full contact), KCL 741 Dermatril® L (splash contact). The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374 with samples of the recommended glove types. This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Other protective equipment: protective clothing

Respiratory protection required when dusts are generated. Recommended Filter type: Filter P 3 (acc. to DIN 3181) for solid and liquid particles of toxic and very toxic substances

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Catalogue No. 820450 Product name 3,4-Dichlorophenol for synthesis

The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.

Environmental exposure controls Do not empty into drains.

9. Physical and chemical properties 9.1 Information on basic physical and chemical properties

Form powder, finecrystalline

Colour white

Odour phenol-like

Odour Threshold No information available.

pH No information available.

Melting point 66 - 68 °C

Boiling point/boiling range 146 °C at 1.013 hPa

Flash point No information available.

Evaporation rate No information available.

Flammability (solid, gas) No information available.

Lower explosion limit No information available.

Upper explosion limit No information available.

Vapour pressure No information available.

Relative vapour density 5,63

Relative density No information available.

Water solubility 9.260 mg/l at 25 °C (experimental)

Partition coefficient: n- log Pow: 3,33 octanol/water Method: (experimental) (Lit.) A remarkable bioaccumulation potential is expected (log Po/w >3).

Autoignition temperature No information available.

Decomposition temperature No information available.

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Catalogue No. 820450 Product name 3,4-Dichlorophenol for synthesis

Viscosity, dynamic No information available.

Explosive properties No information available.

Oxidizing properties No information available.

9.2 Other data none

10. Stability and reactivity

10.1 Reactivity The following applies in general to flammable organic substances and preparations: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.

10.2 Chemical stability The product is chemically stable under standard ambient conditions (room temperature) .

10.3 Possibility of hazardous reactions Violent reactions possible with:

Oxidizing agents, Acid chlorides, Acid anhydrides, acids

10.4 Conditions to avoid no information available

10.5 Incompatible materials Aluminium

10.6 Hazardous decomposition products in the event of fire: See chapter 5.

11. Toxicological information

11.1 Information on toxicological effects Acute inhalation toxicity Symptoms: Possible damages:, mucosal irritations

Skin irritation Causes skin irritation.

Eye irritation Causes serious eye irritation.

Genotoxicity in vitro Ames test Salmonella typhimurium Result: negative (National Toxicology Program)

Specific target organ toxicity - single exposure The substance or mixture is not classified as specific target organ toxicant, single exposure.

Specific target organ toxicity - repeated exposure The substance or mixture is not classified as specific target organ toxicant, repeated exposure.

Aspiration hazard No aspiration toxicity classification

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Catalogue No. 820450 Product name 3,4-Dichlorophenol for synthesis

11.2 Further information Further information Quantitative data on the toxicity of this product are not available.

Further toxicological data:

After absorption of toxic quantities:

agitation, Convulsions

Other information

The following applies to phenols in general: irritant or even caustic effect upon contact with skin or mucous membranes.

Further data:

Other dangerous properties can not be excluded.

Handle in accordance with good industrial hygiene and safety practice.

12. Ecological information

12.1 Toxicity Toxicity to fish LC50 Species: Oryzias latipes (Orange-red killifish) Dose: 1,9 mg/l Exposure time: 96 h (ECOTOX Database)

Toxicity to daphnia and other aquatic invertebrates. EC50 Species: Daphnia magna (Water flea) Dose: 2,77 mg/l Exposure time: 24 h (ECOTOX Database)

Toxicity to algae IC50 Species: Pseudokirchneriella subcapitata (green algae) Dose: 3,2 mg/l Exposure time: 96 h (ECOTOX Database)

12.2 Persistence and degradability No information available.

12.3 Bioaccumulative potential Partition coefficient: n-octanol/water log Pow: 3,33 Method: (experimental) (Lit.) A remarkable bioaccumulation potential is expected (log Po/w >3).

12.4 Mobility in soil No information available.

12.5 Results of PBT and vPvB assessment PBT/vPvB assessment not available as chemical safety assessment not required/not conducted.

12.6 Other adverse effects Additional ecological information Do not allow to run into surface waters, wastewater, or soil.

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Catalogue No. 820450 Product name 3,4-Dichlorophenol for synthesis

13. Disposal considerations Waste treatment methods See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

14. Transport information

ADR/RID UN 2020 CHLOROPHENOLS, SOLID, 6.1, III IATA UN 2020 CHLOROPHENOLS, SOLID, 6.1, III IMDG UN 2020 CHLOROPHENOLS, SOLID, 6.1, III EmS F-A S-A The transport regulations are cited according to international regulations and in the form applicable in Germany. Possible national deviations in other countries are not considered.

15. Regulatory information 15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture

EU regulations Major Accident Hazard 96/82/EC Legislation Dangerous for the environment 9b Quantity 1: 200 t Quantity 2: 500 t

Occupational restrictions Take note of Dir 94/33/EC on the protection of young people at work.

National legislation Storage class VCI 10 - 13 Other liquids and solids

15.2 Chemical Safety Assessment

For this product a chemical safety assessment was not carried out.

16. Other information Full text of H-Statements referred to under sections 2 and 3. H315 Causes skin irritation. H319 Causes serious eye irritation. Full text of R-phrases referred to under sections 2 and 3 R36/38 Irritating to eyes and skin. R51/53 Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.

Training advice Provide adequate information, instruction and training for operators.

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Catalogue No. 820450 Product name 3,4-Dichlorophenol for synthesis

Regional representation: This information is given on the authorised Safety Data Sheet for your country.

Key or legend to abbreviations and acronyms used in the safety data sheet Used abbreviations and acronyms can be looked up at www.wikipedia.org.

The information contained herein is based on the present state of our knowledge. It characterises the product with regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.

The Safety Data Sheets for catalogue items are available at www.merckgroup.com Page 9 of 9 He a lt h 3 2 Fire 2 3 1 Re a c t iv it y 0 Pe rs o n a l Pro t e c t io n Material Safety Data Sheet Acetic anhydride MSDS

Section 1: Chemical Product and Company Identification

Product Name: Acetic anhydride Contact Information: Catalog Codes: SLA1693 Sciencelab.com, Inc. 14025 Smith Rd. CAS#: 108-24-7 Houston, Texas 77396 RTECS: AK1925000 US Sales: 1-800-901-7247 International Sales: 1-281-441-4400 TSCA: TSCA 8(b) inventory: Acetic anhydride Order Online: ScienceLab.com CI#: Not available. CHEMTREC (24HR Emergency Telephone), call: Synonym: 1-800-424-9300 Chemical Formula: (CH3CO)2) International CHEMTREC, call: 1-703-527-3887 For non-emergency assistance, call: 1-281-441-4400

Section 2: Composition and Information on Ingredients

Composition:

Name CAS # % by Weight Acetic anhydride 108-24-7 100

Toxicological Data on Ingredients: Acetic anhydride: ORAL (LD50): Acute: 1780 mg/kg [Rat]. DERMAL (LD50): Acute: 4000 mg/kg [Rabbit].

Section 3: Hazards Identification

Potential Acute Health Effects: Extremely hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Very hazardous in case of skin contact (corrosive). Hazardous in case of skin contact (permeator). Liquid or spray mist may produce tissue damage particularly on mucous membranes of eyes, mouth and respiratory tract. Skin contact may produce burns. Inhalation of the spray mist may produce severe irritation of respiratory tract, characterized by coughing, choking, or shortness of breath. Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering. Potential Chronic Health Effects: CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance is toxic to lungs, mucous membranes. Repeated or prolonged exposure to the substance can produce target organs damage. Repeated or prolonged contact with spray mist may produce chronic eye irritation and severe skin irritation. Repeated or prolonged exposure to spray mist may produce respiratory tract irritation leading to frequent attacks of bronchial infection.

p. 1 Section 4: First Aid Measures

Eye Contact: Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention immediately. Skin Contact: In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Cover the irritated skin with an emollient. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention immediately. Serious Skin Contact: Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medical attention. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention immediately. Serious Inhalation: Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. WARNING: It may be hazardous to the person providing aid to give mouth-to-mouth resuscitation when the inhaled material is toxic, infectious or corrosive. Seek immediate medical attention. Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: Flammable. Auto-Ignition Temperature: 316°C (600.8°F) Flash Points: CLOSED CUP: 49°C (120.2°F). OPEN CUP: 51°C (123.8°F). Flammable Limits: LOWER: 2.7% UPPER: 10.3% Products of Combustion: These products are carbon oxides (CO, CO2). Fire Hazards in Presence of Various Substances: Flammable in presence of heat. Explosion Hazards in Presence of Various Substances: Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in presence of static discharge: Not available. Fire Fighting Media and Instructions: Flammable liquid. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use alcohol foam, water spray or fog. Cool containing vessels with water jet in order to prevent pressure build-up, autoignition or explosion. Special Remarks on Fire Hazards: Not available. Special Remarks on Explosion Hazards: Not available.

Section 6: Accidental Release Measures

Small Spill: Absorb with an inert material and put the spilled material in an appropriate waste disposal.

p. 2 Large Spill: Flammable liquid. Corrosive liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth, sand or other non-combustible material. Do not get water inside container. Do not touch spilled material. Use water spray curtain to divert vapor drift. Prevent entry into sewers, basements or confined areas; dike if needed. Call for assistance on disposal. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities.

Section 7: Handling and Storage

Precautions: Keep container dry. Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do not breathe gas/fumes/ vapor/spray. Never add water to this product. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin and eyes. Storage: Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed and sealed until ready for use. Avoid all possible sources of ignition (spark or flame).

Section 8: Exposure Controls/Personal Protection

Section 9: Physical and Chemical Properties

Physical state and appearance: Liquid. Odor: Strong. Taste: Strong. Molecular Weight: 102.09 g/mole Color: Light. pH (1% soln/water): Not available. Boiling Point: 139.9°C (283.8°F) Melting Point: -73.1 (-99.6°F) Critical Temperature: Not available. Specific Gravity: 1.08 (Water = 1) Vapor Pressure: 0.5 kPa (@ 20°C) Vapor Density: 3.52 (Air = 1)

p. 3 Volatility: Not available. Odor Threshold: 0.1 ppm Water/Oil Dist. Coeff.: Not available. Ionicity (in Water): Not available. Dispersion Properties: Not available. Solubility: Not available.

Section 10: Stability and Reactivity Data

Stability: The product is stable. Instability Temperature: Not available. Conditions of Instability: Not available. Incompatibility with various substances: Not available. Corrosivity: Not available. Special Remarks on Reactivity: Not available. Special Remarks on Corrosivity: Not available. Polymerization: Will not occur.

Section 11: Toxicological Information

Routes of Entry: Dermal contact. Eye contact. Inhalation. Ingestion. Toxicity to Animals: WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oral toxicity (LD50): 1780 mg/kg [Rat]. Acute dermal toxicity (LD50): 4000 mg/kg [Rabbit]. Acute toxicity of the vapor (LC50): 1000 4 hours [Rat]. Chronic Effects on Humans: Causes damage to the following organs: lungs, mucous membranes. Other Toxic Effects on Humans: Extremely hazardous in case of skin contact (irritant), of ingestion, . Very hazardous in case of skin contact (corrosive). Hazardous in case of skin contact (permeator), of eye contact (corrosive), of inhalation (lung corrosive). Special Remarks on Toxicity to Animals: Not available. Special Remarks on Chronic Effects on Humans: Not available. Special Remarks on other Toxic Effects on Humans: Not available.

Section 12: Ecological Information

p. 4 Section 13: Disposal Considerations

Waste Disposal:

Section 14: Transport Information

DOT Classification: Class 8: Corrosive material Identification: : Acetic Anhydride UNNA: UN1715 PG: II Special Provisions for Transport: Not available.

Section 15: Other Regulatory Information

Federal and State Regulations: Pennsylvania RTK: Acetic anhydride Massachusetts RTK: Acetic anhydride TSCA 8(b) inventory: Acetic anhydride CERCLA: Hazardous substances.: Acetic anhydride Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). Other Classifications: WHMIS (Canada): CLASS B-3: Combustible liquid with a flash point between 37.8°C (100°F) and 93.3°C (200°F). CLASS E: Corrosive liquid. DSCL (EEC): R10- Flammable. R20/22- Harmful by inhalation and if swallowed. R34- Causes burns. HMIS (U.S.A.): Health Hazard: 3 Fire Hazard: 2 Reactivity: 0 Personal Protection: National Fire Protection Association (U.S.A.): Health: 3 Flammability: 2 Reactivity: 1 Specific hazard: Protective Equipment: Gloves. Full suit. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate. Face shield.

Section 16: Other Information

References: Not available. Other Special Considerations: Not available. Created: 10/10/2005 08:13 PM Last Updated: 05/21/2013 12:00 PM The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume

p. 6 He a lt h 2 3 Fire 3 1 0 Re a c t iv it y 0 Pe rs o n a l Pro t e c t io n G Material Safety Data Sheet Ethyl acetate MSDS

Section 1: Chemical Product and Company Identification

Product Name: Ethyl acetate Contact Information: Catalog Codes: SLE2452, SLE2317 Sciencelab.com, Inc. 14025 Smith Rd. CAS#: 141-78-6 Houston, Texas 77396 RTECS: AH5425000 US Sales: 1-800-901-7247 International Sales: 1-281-441-4400 TSCA: TSCA 8(b) inventory: Ethyl acetate Order Online: ScienceLab.com CI#: Not available. CHEMTREC (24HR Emergency Telephone), call: Synonym: Acetic Acid, Ethyl Ester Acetic Ether 1-800-424-9300 Chemical Name: Ethyl Acetate International CHEMTREC, call: 1-703-527-3887 Chemical Formula: C4-H8-O2 For non-emergency assistance, call: 1-281-441-4400

Section 2: Composition and Information on Ingredients

Composition:

Name CAS # % by Weight Ethyl acetate 141-78-6 100

Toxicological Data on Ingredients: Ethyl acetate: ORAL (LD50): Acute: 5620 mg/kg [Rat]. 4100 mg/kg [Mouse]. 4935 mg/kg [Rabbit]. VAPOR (LC50): Acute: 45000 mg/m 3 hours [Mouse]. 16000 ppm 6 hours [Rat].

Section 3: Hazards Identification

Potential Acute Health Effects: Hazardous in case of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant, permeator), of eye contact (irritant). Potential Chronic Health Effects: CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance is toxic to mucous membranes, upper respiratory tract. The substance may be toxic to blood, kidneys, liver, central nervous system (CNS). Repeated or prolonged exposure to the substance can produce target organs damage.

Section 4: First Aid Measures

p. 1 Eye Contact: Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention. Skin Contact: Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold water may be used. Serious Skin Contact: Not available. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention if symptoms appear. Serious Inhalation: Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek medical attention. Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear. Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: Flammable. Auto-Ignition Temperature: 426.67°C (800°F) Flash Points: CLOSED CUP: -4.4°C (24.1°F). (TAG) OPEN CUP: 7.2°C (45°F) (Cleveland). Flammable Limits: LOWER: 2.2% UPPER: 9% Products of Combustion: These products are carbon oxides (CO, CO2). Fire Hazards in Presence of Various Substances: Highly flammable in presence of open flames and sparks, of heat. Slightly flammable to flammable in presence of oxidizing materials, of acids, of alkalis. Non-flammable in presence of shocks. Explosion Hazards in Presence of Various Substances: Risks of explosion of the product in presence of static discharge: Not available. Slightly explosive in presence of heat. Non- explosive in presence of shocks. Fire Fighting Media and Instructions: Flammable liquid, soluble or dispersed in water. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use alcohol foam, water spray or fog. Special Remarks on Fire Hazards: Vapor may travel considerable distance to source of ignition and flash back. When heated to decomposition it emits acrid smoke and irritating fumes. Special Remarks on Explosion Hazards: The liquid produces a vapor that forms explosive mixtures with air at normal temperatures. Explosive reaction with lithium tetrahydroaluminate.

Section 6: Accidental Release Measures

Small Spill: Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container.

p. 2 Large Spill: Flammable liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth, sand or other non-combustible material. Do not touch spilled material. Prevent entry into sewers, basements or confined areas; dike if needed. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities.

Section 7: Handling and Storage

Precautions: Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do not breathe gas/fumes/ vapor/spray. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Keep away from incompatibles such as oxidizing agents, acids, alkalis. Storage: Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed and sealed until ready for use. Avoid all possible sources of ignition (spark or flame). Moisture sensitive.

Section 8: Exposure Controls/Personal Protection

Engineering Controls: Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respective threshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location. Personal Protection: Safety glasses. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure Limits: TWA: 400 (ppm) from OSHA (PEL) [United States] TWA: 400 from ACGIH (TLV) [United States] TWA: 1400 (mg/m3) from NIOSH [United States] TWA: 400 (ppm) from NIOSH [United States] TWA: 400 (ppm) [Canada] TWA: 1440 (mg/m3) [Canada] TWA: 1400 (mg/m3) from OSHA (PEL) [United States]3 Consult local authorities for acceptable exposure limits.

Section 9: Physical and Chemical Properties

Physical state and appearance: Liquid. Odor: Ethereal. Fruity. (Slight.) Taste: Bittersweet, wine-like burning taste Molecular Weight: 88.11 g/mole Color: Colorless. pH (1% soln/water): Not available. Boiling Point: 77°C (170.6°F) Melting Point: -83°C (-117.4°F) Critical Temperature: 250°C (482°F) Specific Gravity: 0.902 (Water = 1) Vapor Pressure: 12.4 kPa (@ 20°C)

p. 3 Vapor Density: 3.04 (Air = 1) Volatility: Not available. Odor Threshold: 3.9 ppm Water/Oil Dist. Coeff.: The product is more soluble in oil; log(oil/water) = 0.7 Ionicity (in Water): Not available. Dispersion Properties: See solubility in water, diethyl ether, acetone. Solubility: Soluble in cold water, hot water, diethyl ether, acetone, alcohol, benzene.

Section 10: Stability and Reactivity Data

Stability: The product is stable. Instability Temperature: Not available. Conditions of Instability: Heat, ignition sources (flames, sparks, static), incompatible materials Incompatibility with various substances: Reactive with oxidizing agents, acids, alkalis. Corrosivity: Non-corrosive in presence of glass. Special Remarks on Reactivity: Also incompatible with nitrates, chlorosulfonic acid, oleum, potassium-tert-butoxide, and lithium tetrahydroaluminate. Moisture sensitive. On storage, it is slowly decomposed by water. Special Remarks on Corrosivity: Not available. Polymerization: Will not occur.

Section 11: Toxicological Information

Routes of Entry: Absorbed through skin. Eye contact. Inhalation. Ingestion. Toxicity to Animals: WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oral toxicity (LD50): 4100 mg/kg [Mouse]. Acute toxicity of the vapor (LC50): 45000 mg/m3 3 hours [Mouse]. Chronic Effects on Humans: CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH. Causes damage to the following organs: mucous membranes, upper respiratory tract. May cause damage to the following organs: blood, kidneys, liver, central nervous system (CNS). Other Toxic Effects on Humans: Hazardous in case of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant, permeator). Special Remarks on Toxicity to Animals: LD50 [Rabbit] - Route: skin; Dose >20,000 ml/kg Special Remarks on Chronic Effects on Humans: May affect genetic material (mutagenic). May cause adverse reproductive effects. based on animal test data. No human data found at this time. Special Remarks on other Toxic Effects on Humans: Acute Potential Health Effects: Skin: May cause skin irritation. Eyes: Causes eye irritation. May cause irritation of the conjunctivia. Inhalation: May cause respiratory tract and mucous membrane irritation. May affect respiration and may cause acute pulmonary edema. May affect gastrointestinal tract (nausea, vomiting). May affect behavior/central nervous system (mild central nervous system depression - exhilaration, talkativeness, boastfulness, belligerancy, vertigo, diplopia, drowsiness, slurred speech, slowed reaction time, dizziness, lightheadedness, somnolence, ataxia, unconciousness, irritability, fatigue, sleep disturbances, reduced memory and concentration, stupor, coma), cardiovascular system (peripheral vascular collapse (shock) - rapid pulse, hypotension, cold pale skin, hypothermia). Other symptoms may include: flushing of face and sweating.

p. 4 Ingestion: May cause gastrointestinal tract irritation with nausea and vomiting. May affect blood, behavior/central nervous system (CNS depression - effects may be similar to that of inhalation). Chronic Potential Health Effects: Skin: Repeated or prolonged skin contact may cause drying and cracking of the skin. IngestIon: Prolonged or repeated ingestion may affect the liver. Inhalation: Prolonged inhalation may affect behavior/central nervous system (symptoms similar to those of acute inhalation), and cause liver, kidney, lung, and heart damage. It may also affect metabolism, and blood (anemia, leukocytosis).

Section 12: Ecological Information

Ecotoxicity: Ecotoxicity in water (LC50): 220 mg/l 96 hours [Fish (Fathead minnow)]. 212.5 ppm 96 hours [Fish (Indian catfish)]. BOD5 and COD: Not available. Products of Biodegradation: Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic. Special Remarks on the Products of Biodegradation: Not available.

Section 13: Disposal Considerations

Waste Disposal: Waste must be disposed of in accordance with federal, state and local environmental control regulations.

Section 14: Transport Information

DOT Classification: CLASS 3: Flammable liquid. Identification: : Ethyl Acetate UNNA: 1173 PG: II Special Provisions for Transport: Not available.

Section 15: Other Regulatory Information

Federal and State Regulations: Connecticut hazardous material survey.: Ethyl acetate Illinois toxic substances disclosure to employee act: Ethyl acetate Illinois chemical safety act: Ethyl acetate New York release reporting list: Ethyl acetate Rhode Island RTK hazardous substances: Ethyl acetate Pennsylvania RTK: Ethyl acetate Florida: Ethyl acetate Minnesota: Ethyl acetate Massachusetts RTK: Ethyl acetate Massachusetts spill list: Ethyl acetate New Jersey: Ethyl acetate New Jersey spill list: Ethyl acetate Louisiana spill reporting: Ethyl acetate California Director's list of Hazardous Substances: Ethyl acetate TSCA 8(b) inventory: Ethyl acetate TSCA 4(a) final test rules: Ethyl acetate TSCA 8(a) IUR: Ethyl acetate TSCA 12(b) annual export notification: Ethyl acetate CERCLA: Hazardous substances.: Ethyl acetate: 5000 lbs. (2268 kg) Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances. Other Classifications: WHMIS (Canada): CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F). DSCL (EEC): R11- Highly flammable. R36- Irritating to eyes. S2- Keep out of the reach of children. S16- Keep away from sources of ignition - No smoking. S26- In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S33- Take precautionary measures against static discharges. S46- If swallowed, seek medical advice immediately and show this container or label.

p. 5 HMIS (U.S.A.): Health Hazard: 2 Fire Hazard: 3 Reactivity: 0 Personal Protection: g National Fire Protection Association (U.S.A.): Health: 1 Flammability: 3 Reactivity: 0 Specific hazard: Protective Equipment: Gloves. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate. Safety glasses.

Section 16: Other Information

References: Not available. Other Special Considerations: Not available. Created: 10/10/2005 08:18 PM Last Updated: 05/21/2013 12:00 PM

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.com has been advised of the possibility of such damages.

p. 6 2/23/2018 4-Chloro-2-aminophenol | C6H6ClNO - PubChem

NIH U.S. National Library of Medicine National Center for Biotechnology Information

O P E N

CHEMISTRY Search Compounds  D A T A B A S E

 Compound Summary for CID 7265

4-Chloro-2-aminophenol  Cite this Record

   

STRUCTURE VENDORS LITERATURE PATENTS BIOACTIVITIES

PubChem CID: 7265 2-Amino-4-chlorophenol; 95-85-2; 5-CHLORO-2-HYDROXYANILINE; Phenol, 2-amino-4- Chemical Names: chloro-; Fouramine PY; 4-Chloro-2-aminophenol More...

Molecular Formula: C6H6ClNO or HOC6H3(NH2)Cl Molecular Weight: 143.57 g/mol InChI Key: SWFNPENEBHAHEB-UHFFFAOYSA-N

Substance Registry: FDA UNII

Safety Summary: Laboratory Chemical Safety Summary (LCSS)

2-Amino-4-chlorophenol is a light brown colored crystalline solid. It may be toxic by ingestion. It is insoluble in water. It is used to make other chemicals.  Physical Description from CAMEO Chemicals

PUBCHEM  COMPOUND  4-CHLORO-2-AMINOPHENOL Modify Date: 2018-02-17; Create Date: 2005-03-26

https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-4-chlorophenol 1/28 2/23/2018 4-Chloro-2-aminophenol | C6H6ClNO - PubChem

 Contents

1 2D Structure

2 3D Conformer

3 Names and Identifiers

4 Chemical and Physical Properties

5 Related Records

6 Chemical Vendors

7 Safety and Hazards

8 Toxicity

9 Literature

10 Patents

11 Biological Test Results

12 Classification

13 Information Sources

https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-4-chlorophenol 2/28 2/23/2018 4-Chloro-2-aminophenol | C6H6ClNO - PubChem

1 2D Structure

 Search  Download  Get Image

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 from PubChem

https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-4-chlorophenol 3/28 2/23/2018 4-Chloro-2-aminophenol | C6H6ClNO - PubChem

2 3D Conformer

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 Show Hydrogens  Show Atoms  Animate

 from PubChem

https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-4-chlorophenol 4/28 2/23/2018 4-Chloro-2-aminophenol | C6H6ClNO - PubChem

3 Names and Identifiers

3.1 Computed Descriptors

3.1.1 IUPAC Name

2-amino-4-chlorophenol  from PubChem

3.1.2 InChI

InChI=1S/C6H6ClNO/c7-4-1-2-6(9)5(8)3-4/h1-3,9H,8H2  from PubChem

3.1.3 InChI Key

SWFNPENEBHAHEB-UHFFFAOYSA-N  from PubChem

3.1.4 Canonical SMILES

C1=CC(=C(C=C1Cl)N)O  from PubChem

3.2 Molecular Formula

C6H6ClNO  from ILO-ICSC, PubChem

HOC6H3(NH2)Cl  from ILO-ICSC

3.3 Other Identifiers

3.3.1 CAS

95-85-2  from CAMEO Chemicals, ChemIDplus, DTP/NCI, EPA Chemicals under the TSCA, EPA DSStox, European Che…

3.3.2 EC Number

202-458-9  from European Chemicals Agency - ECHA https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-4-chlorophenol 5/28 2/23/2018 4-Chloro-2-aminophenol | C6H6ClNO - PubChem

3.3.3 ICSC Number

1652  from ILO-ICSC

3.3.4 NSC Number

247814  from DTP/NCI

3.3.5 RTECS Number

SJ5700000  from ILO-ICSC, The National Institute for Occupational Safety and Health - NIOSH

3.3.6 UN Number

2673  from CAMEO Chemicals, DOT Emergency Response Guidebook, ILO-ICSC, NJDOH RTK Hazardous Substance…

3.3.7 UNII

2Z43LEA3DX  from FDA/SPL Indexing Data

3.3.8 Wikipedia

Title 4-chloro-2-aminophenol

Description chemical compound

 from Wikipedia

3.4 Synonyms

3.4.1 MeSH Entry Terms

1. 2-amino-4-chlorophenol 2. 2-amino-4-chlorophenol hydrochloride 3. 2-amino-4-chlorophenol, sulfate(1:1) 4. 4-chloro-2-aminophenol 5. 5-chloro-2-hydroxyaniline

 from MeSH

https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-4-chlorophenol 6/28 2/23/2018 4-Chloro-2-aminophenol | C6H6ClNO - PubChem

3.4.2 Depositor-Supplied Synonyms

1. 2-Amino-4-chlorophenol 11. UNII-2Z43LEA3DX 21. MFCD00007694 31 2. 95-85-2 12. C.I. 76525 22. 2-amino-4-chlorphenol 32 3. 5-CHLORO-2-HYDROXYANILINE 13. CCRIS 4579 23. amino-4-chlorophenol 33 4. Phenol, 2-amino-4-chloro- 14. 4-chloro-2-amino phenol 24. 2-amino4-chlorphenol 34 5. Fouramine PY 15. EINECS 202-458-9 25. 2-amino 4-chlorophenol 35 6. 4-Chloro-2-aminophenol 16. UN2673 26. AC1L1ODP 36 7. 2-Hydroxy-5-chloroaniline 17. NSC 247814 27. 2-Amino-4-Chloro phenol 37 8. p-Chloro-o-aminophenol 18. BRN 0774859 28. DSSTox_CID_4473 38 9. C.I. Oxidation Base 18 19. 2Z43LEA3DX 29. ACMC-209s5j 39 10. 2-amino-4-chloro-phenol 20. SWFNPENEBHAHEB-UHFFFAOYSA-N 30. 2-amino -4-chloro-phenol 40

 from PubChem

https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-4-chlorophenol 7/28 2/23/2018 4-Chloro-2-aminophenol | C6H6ClNO - PubChem

4 Chemical and Physical Properties

4.1 Computed Properties

Property Name Property Value

Molecular Weight 143.57 g/mol

Hydrogen Bond Donor Count 2

Hydrogen Bond Acceptor Count 2

Rotatable Bond Count 0

Complexity 99.1

AAADcYBiIAAEAAAAAAAAAAAAAAAAAAAAAAAwAAAA AAAAAAABAAAAHgIQCAAACA6BkCAwxoBAAgCAACRC CACTVS Substructure Key Fingerprint QACCAAAgJwAIiAAHbogKJiKTk5OAcABk0BEI2AeQQAA AACAAAAIAEAAAQAAABAAgAAAAAAAAAA==

Topological Polar Surface Area 46.2 A^2

Monoisotopic Mass 143.014 g/mol

Exact Mass 143.014 g/mol

XLogP3 1.8

Compound Is Canonicalized true

Formal Charge 0

Heavy Atom Count 9

Defined Atom Stereocenter Count 0

Undefined Atom Stereocenter Count 0

Defined Bond Stereocenter Count 0

Undefined Bond Stereocenter Count 0

Isotope Atom Count 0

Covalently-Bonded Unit Count 1

 from PubChem

4.2 Experimental Properties

4.2.1 Physical Description

2-Amino-4-chlorophenol is a light brown colored crystalline solid. It may be toxic by ingestion. It is insoluble in water. It is used to make other chemicals.  from CAMEO Chemicals

DryPowder  from EPA Chemicals under the TSCA

BROWN CRYSTALLINE POWDER WITH CHARACTERISTIC ODOUR. https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-4-chlorophenol 8/28 2/23/2018 4-Chloro-2-aminophenol | C6H6ClNO - PubChem

 from ILO-ICSC

4.2.2 Melting Point

284 to 286° F (decomposes) (NTP, 1992)  from CAMEO Chemicals

140°C  from ILO-ICSC

4.2.3 Flash Point

170°C  from ILO-ICSC

4.2.4 Solubility

less than 1 mg/mL at 68° F (NTP, 1992)  from CAMEO Chemicals

in water, g/100ml at 20°C: 0.3  from ILO-ICSC

4.2.5 Vapor Density

(air = 1): 5.0  from ILO-ICSC

4.2.6 Vapor Pressure

Vapour pressure Pa at 25°C: 0.2  from ILO-ICSC

4.2.7 LogP

1.24  from ILO-ICSC

4.2.8 Auto-Ignition

500°C  from ILO-ICSC

https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-4-chlorophenol 9/28 2/23/2018 4-Chloro-2-aminophenol | C6H6ClNO - PubChem

4.2.9 Kovats Retention Index

Semi-standard non-polar 1477.6

Standard polar 2543

 from NIST

4.3 Spectral Properties

4.3.1 Infrared Spectra

Infrared Spectra: 1 of 3 (FTIR Spectra)

Technique KBr WAFER

Source of Sample The Sherwin-Williams Company, Sherwin Williams Chemical Division

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 from SpectraBase

Infrared Spectra: 2 of 3 (FTIR Spectra)

Technique KBr WAFER

Source of Sample The Sherwin-Williams Company, Cleveland, Ohio

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 from SpectraBase

Infrared Spectra: 3 of 3 (Vapor Phase IR Spectra) https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-4-chlorophenol 10/28 2/23/2018 4-Chloro-2-aminophenol | C6H6ClNO - PubChem

Infrared Spectra: 3 of 3 (Vapor Phase IR Spectra)

Instrument Name DIGILAB FTS-14

Technique VAPOR PHASE

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 from SpectraBase

4.3.2 1D NMR Spectra

1D NMR Spectra: 1 of 5 (1H NMR Spectra)

Instrument Name Varian A-60

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 from SpectraBase

1D NMR Spectra: 2 of 5 (13C NMR Spectra)

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https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-4-chlorophenol 11/28 2/23/2018 4-Chloro-2-aminophenol | C6H6ClNO - PubChem

 from SpectraBase

1D NMR Spectra: 3 of 5 (1H NMR Spectra)

Instrument Name BRUKER AC-300

Source of Sample Tokyo Kasei Kogyo Company, Ltd., Tokyo, Japan

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 from SpectraBase View All 5 1D NMR Spectra

4.3.3 Mass Spectrometry

4.3.3.1 GC-MS

  1 of 3  

NIST Number 291137

Library Main library

Total Peaks 85

m/z Top Peak 143

m/z 2nd Highest 80

m/z 3rd Highest 145

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 from NIST

https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-4-chlorophenol 12/28 2/23/2018 4-Chloro-2-aminophenol | C6H6ClNO - PubChem

5 Related Records

5.1 Related Compounds with Annotation

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 from PubChem

5.2 Related Compounds

Same Tautomer 3 records

Same Connectivity 2 records

Same Parent, Tautomer 9 records

Same Parent, Connectivity 8 records

Same Parent, Exact 7 records

Mixtures, Components, and 25 records Neutralized Forms

Similar Compounds 57 records

Similar Conformers 4411 records

 from PubChem

5.3 Substances

5.3.1 Related Substances

All 183 records

Same 122 records

Mixture 61 records

 from PubChem

5.3.2 Substances by Category

CLICK TO LOAD... https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-4-chlorophenol 13/28 2/23/2018 4-Chloro-2-aminophenol | C6H6ClNO - PubChem

 from PubChem

5.4 Entrez Crosslinks

PubMed 16 records

Taxonomy 1 record

Gene 1 record

 from PubChem

https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-4-chlorophenol 14/28 2/23/2018 4-Chloro-2-aminophenol | C6H6ClNO - PubChem

6 Chemical Vendors

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 from PubChem

https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-4-chlorophenol 15/28 2/23/2018 4-Chloro-2-aminophenol | C6H6ClNO - PubChem

7 Safety and Hazards

7.1 Hazards Identification

7.1.1 GHS Classification

Signal: Warning GHS Hazard Statements Aggregated GHS information provided by 69 companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria by 10 of 69 companies. For more detailed information, please visit ECHA C&L website

Of the 9 notification(s) provided by 59 of 69 companies with hazard statement code(s):

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] H315 (50.85%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (50.85%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (47.46%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] H411 (44.07%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

Precautionary Statement Codes P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P391, P403+P233, P405, and P501 (The corresponding statement to each P-code can be found here.)  from European Chemicals Agency - ECHA View all (2) GHS Classification entries

7.1.2 Health Hazard

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016)  from CAMEO Chemicals

7.1.3 Fire Hazard

https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-4-chlorophenol 16/28 2/23/2018 4-Chloro-2-aminophenol | C6H6ClNO - PubChem

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways. (ERG, 2016)  from CAMEO Chemicals

Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  from ILO-ICSC

7.2 Safety and Hazard Properties

7.2.1 Physical Dangers

The vapour is heavier than air.  from ILO-ICSC

7.2.2 Chemical Dangers

Decomposes on heating and on burning. This produces toxic and corrosive fumes including hydrogen chloride and nitrogen oxides. Reacts with oxidants.  from ILO-ICSC

7.3 First Aid Measures

7.3.1 First Aid

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. Phenols are very toxic poisons AND corrosive and irritating, so that inducing vomiting may make medical problems worse. IMMEDIATELY call a hospital or poison control center and locate activated charcoal, egg whites, or milk in case the medical advisor recommends administering one of them. If advice from a physician is not readily available and the victim is conscious and not convulsing, give the victim a glass of activated charcoal slurry in water or, if this is not available, a glass of milk, or beaten egg whites and IMMEDIATELY transport victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, assure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)  from CAMEO Chemicals

7.3.2 Inhalation First Aid

Fresh air, rest.  from ILO-ICSC https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-4-chlorophenol 17/28 2/23/2018 4-Chloro-2-aminophenol | C6H6ClNO - PubChem

7.3.3 Skin First Aid

Rinse and then wash skin with water and soap.  from ILO-ICSC

7.3.4 Eye First Aid

Rinse with plenty of water for several minutes (remove contact lenses if easily possible).  from ILO-ICSC

7.3.5 Ingestion First Aid

Rinse mouth.  from ILO-ICSC

7.4 Fire Fighting Measures

7.4.1 Fire Fighting

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: SMALL FIRE: Dry chemical, CO2 or water spray. LARGE FIRE: Water spray, fog or regular foam. Move containers from fire area if you can do it without risk. Dike fire- control water for later disposal; do not scatter the material. Use water spray or fog; do not use straight streams. FIRE INVOLVING TANKS OR CAR/TRAILER LOADS: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2016)  from CAMEO Chemicals

Use water spray, foam, powder, carbon dioxide.  from ILO-ICSC

7.5 Accidental Release Measures

7.5.1 Isolation and Evacuation

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)  from CAMEO Chemicals

7.5.2 Spillage Disposal

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-4-chlorophenol 18/28 2/23/2018 4-Chloro-2-aminophenol | C6H6ClNO - PubChem store and dispose of according to local regulations.  from ILO-ICSC

7.6 Handling and Storage

7.6.1 Nonfire Spill Response

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2016)  from CAMEO Chemicals

7.6.2 Safe Storage

Separated from oxidants and food and feedstuffs. Ventilation along the floor.  from ILO-ICSC

7.7 Exposure Control and Personal Protection

7.7.1 Inhalation Risk

A nuisance-causing concentration of airborne particles can be reached quickly when dispersed, especially if powdered.  from ILO-ICSC

7.7.2 Effects of Long Term Exposure

Repeated or prolonged contact may cause skin sensitization.  from ILO-ICSC

7.7.3 Fire Prevention

NO open flames.  from ILO-ICSC

7.7.4 Exposure Prevention

AVOID ALL CONTACT!  from ILO-ICSC

7.7.5 Inhalation Prevention

Use local exhaust.  from ILO-ICSC https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-4-chlorophenol 19/28 2/23/2018 4-Chloro-2-aminophenol | C6H6ClNO - PubChem

7.7.6 Skin Prevention

Protective gloves. Protective clothing.  from ILO-ICSC

7.7.7 Eye Prevention

Wear safety goggles.  from ILO-ICSC

7.7.8 Ingestion Prevention

Do not eat, drink, or smoke during work.  from ILO-ICSC

7.7.9 Protective Equipment and Clothing

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. (ERG, 2016)  from CAMEO Chemicals

7.8 Stability and Reactivity

7.8.1 Air and Water Reactions

This compound may be sensitive to prolonged exposure to air and/or light. Insoluble in water.  from CAMEO Chemicals

7.8.2 Reactive Group

Phenols and Cresols Aryl Halides Amines, Aromatic  from CAMEO Chemicals

7.8.3 Reactivity Profile

2-AMINO-4-CHLOROPHENOL may react with strong oxidizing agents. (NTP, 1992)  from CAMEO Chemicals

7.9 Transport Information https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-4-chlorophenol 20/28 2/23/2018 4-Chloro-2-aminophenol | C6H6ClNO - PubChem 7.9.1 DOT ID and Guide

2673 151  from DOT Emergency Response Guidebook

7.9.2 DOT Label

Poison  from CAMEO Chemicals

7.9.3 UN Classification

UN Hazard Class: 6.1; UN Pack Group: II  from ILO-ICSC

7.9.4 Emergency Response

Transport Emergency Card: TEC (R)-61GT2-II.  from ILO-ICSC

https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-4-chlorophenol 21/28 2/23/2018 4-Chloro-2-aminophenol | C6H6ClNO - PubChem

8 Toxicity

8.1 Toxicological Information

8.1.1 NIOSH Toxicity Data

 Download

1 to 3 of 3

Measurement System Route/Organism Dose Effect Date

mutation in /Salmonella 333 µg/plate (-enzymatic November Mutation Data microorganisms typhimurium activation step) 2007

Acute Toxicity lethal dose (50 percent kill): November oral/mouse Data 1030 mg/kg 2007

Acute Toxicity lethal dose (50 percent kill): 690 November oral/rat Data mg/kg 2007

 from The National Institute for Occupational Safety and Health - NIOSH

8.1.2 Exposure Routes

The substance can be absorbed into the body by inhalation and by ingestion.  from ILO-ICSC

8.1.3 Eye Symptoms

Redness.  from ILO-ICSC

https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-4-chlorophenol 22/28 2/23/2018 4-Chloro-2-aminophenol | C6H6ClNO - PubChem

9 Literature

9.1 Depositor Provided PubMed Citations

CLICK TO LOAD...

 from PubChem

9.2 NLM Curated PubMed Citations

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 from PubChem

9.3 Springer Nature References

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 from Springer Nature

https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-4-chlorophenol 23/28 2/23/2018 4-Chloro-2-aminophenol | C6H6ClNO - PubChem

10 Patents

10.1 Depositor-Supplied Patent Identifiers

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 from PubChem

https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-4-chlorophenol 24/28 2/23/2018 4-Chloro-2-aminophenol | C6H6ClNO - PubChem

11 Biological Test Results

11.1 BioAssay Results

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 from PubChem

https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-4-chlorophenol 25/28 2/23/2018 4-Chloro-2-aminophenol | C6H6ClNO - PubChem

12 Classification

12.1 Ontologies

12.1.1 MeSH Tree

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 from MeSH

12.1.2 WIPO IPC

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 from WIPO

12.1.3 ChemIDplus

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 from ChemIDplus

https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-4-chlorophenol 26/28 2/23/2018 4-Chloro-2-aminophenol | C6H6ClNO - PubChem

13 Information Sources

1. CAMEO Chemicals /source/CAMEO Chemicals 2-AMINO-4-CHLOROPHENOL https://cameochemicals.noaa.gov/chemical/2399 https://cameochemicals.noaa.gov/chemical/2399

2. ChemIDplus /source/ChemIDplus 2-Amino-4-chlorophenol https://chem.nlm.nih.gov/chemidplus/sid/0000095852 https://chem.nlm.nih.gov/chemidplus/sid/0000095852 ChemIDplus Chemical Information Classification https://chem.sis.nlm.nih.gov/chemidplus/chemidheavy.jsp https://chem.sis.nlm.nih.gov/chemidplus/chemidheavy.jsp

3. DTP/NCI /source/DTP/NCI 2-Amino-4-chlorophenol https://dtp.cancer.gov/dtpstandard/servlet/dwindex?searchtype=NSC&outputformat=html&searchlist=247814 https://dtp.cancer.gov/dtpstandard/servlet/dwindex?searchtype=NSC&outputformat=html&searchlist=247814

4. EPA Chemicals under the TSCA /source/EPA Chemicals under the TSCA Phenol, 2-amino-4-chloro- http://www.epa.gov/chemical-data-reporting http://www.epa.gov/chemical-data-reporting

5. EPA DSStox /source/EPA DSStox 2-Amino-4-chlorophenol https://comptox.epa.gov/dashboard/dsstoxdb/results?search=DTXSID5024473 https://comptox.epa.gov/dashboard/dsstoxdb/results?search=DTXSID5024473

6. European Chemicals Agency - ECHA /source/European Chemicals Agency - ECHA 2-amino-4-chlorophenol https://www.echa.europa.eu https://www.echa.europa.eu 2-amino-4-chlorophenol https://www.echa.europa.eu/web/guest/information-on-chemicals/cl-inventory-database/-/discli/details/43508 https://www.echa.europa.eu/web/guest/information-on-chemicals/cl-inventory-database/-/discli/details/43508

7. ILO-ICSC /source/ILO-ICSC 2-AMINO-4-CHLOROPHENOL http://www.ilo.org/dyn/icsc/showcard.display?p_version=2&p_card_id=1652 http://www.ilo.org/dyn/icsc/showcard.display? p_version=2&p_card_id=1652

8. The National Institute for Occupational Safety and Health - NIOSH /source/The National Institute for Occupational Safety and Health - NIOSH Phenol, 2-amino-4-chloro- https://www.cdc.gov/niosh-rtecs/SJ56F9A0.html https://www.cdc.gov/niosh-rtecs/SJ56F9A0.html

9. DOT Emergency Response Guidebook /source/DOT Emergency Response Guidebook 2-amino-4-chlorophenol http://phmsa.dot.gov/hazmat/outreach-training/erg http://phmsa.dot.gov/hazmat/outreach-training/erg

10. NJDOH RTK Hazardous Substance List /source/NJDOH RTK Hazardous Substance List 2-amino-4-chlorophenol http://nj.gov/health/eoh/rtkweb/documents/fs/0070.pdf http://nj.gov/health/eoh/rtkweb/documents/fs/0070.pdf

11. NITE-CMC /source/NITE-CMC 2-Amino-4-chlorophenol http://www.safe.nite.go.jp/english/ghs/09-mhlw-0035e.html http://www.safe.nite.go.jp/english/ghs/09-mhlw-0035e.html

12. FDA/SPL Indexing Data /source/FDA/SPL Indexing Data 2Z43LEA3DX https://www.fda.gov/ForIndustry/DataStandards/SubstanceRegistrationSystem-UniqueIngredientIdentifierUNII/ https://www.fda.gov/ForIndustry/DataStandards/SubstanceRegistrationSystem-UniqueIngredientIdentifierUNII/ https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-4-chlorophenol 27/28 2/23/2018 4-Chloro-2-aminophenol | C6H6ClNO - PubChem

13. NIST /source/NIST 5-Chloro-2-hydroxyaniline http://www.nist.gov/srd/nist1a.cfm http://www.nist.gov/srd/nist1a.cfm

14. SpectraBase /source/SpectraBase https://spectrabase.com/compound/7QczlZxe91o#EE9wBwV5YDF https://spectrabase.com/compound/7QczlZxe91o#EE9wBwV5YDF https://spectrabase.com/compound/7QczlZxe91o#KG5oDMwsYt0 https://spectrabase.com/compound/7QczlZxe91o#KG5oDMwsYt0 https://spectrabase.com/compound/7QczlZxe91o#BHOY9chTOml https://spectrabase.com/compound/7QczlZxe91o#BHOY9chTOml https://spectrabase.com/compound/7QczlZxe91o#JLQNjqvaX3W https://spectrabase.com/compound/7QczlZxe91o#JLQNjqvaX3W https://spectrabase.com/compound/7QczlZxe91o#2mmnIoXnweU https://spectrabase.com/compound/7QczlZxe91o#2mmnIoXnweU https://spectrabase.com/compound/7QczlZxe91o#7rjbj0KF1lz https://spectrabase.com/compound/7QczlZxe91o#7rjbj0KF1lz https://spectrabase.com/compound/7QczlZxe91o#I1uA1aQ3GBc https://spectrabase.com/compound/7QczlZxe91o#I1uA1aQ3GBc https://spectrabase.com/compound/7QczlZxe91o#27IrfP5YBGi https://spectrabase.com/compound/7QczlZxe91o#27IrfP5YBGi

15. Springer Nature /source/Springer Nature 2-amino-4-chlorophenol https://pubchem.ncbi.nlm.nih.gov/substance/341144435 https://pubchem.ncbi.nlm.nih.gov/substance/341144435

16. Wikipedia /source/Wikipedia 4-chloro-2-aminophenol https://www.wikidata.org/wiki/Q27255828 https://www.wikidata.org/wiki/Q27255828

17. PubChem Data deposited in or computed by PubChem https://pubchem.ncbi.nlm.nih.gov https://pubchem.ncbi.nlm.nih.gov

18. MeSH /source/MeSH 2-amino-4-chlorophenol https://www.ncbi.nlm.nih.gov/mesh/67027296 https://www.ncbi.nlm.nih.gov/mesh/67027296 MeSH Tree http://www.nlm.nih.gov/mesh/meshhome.html http://www.nlm.nih.gov/mesh/meshhome.html

19. WIPO /source/WIPO International Patent Classification http://www.wipo.int/classifications/ipc/ http://www.wipo.int/classifications/ipc/

https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-4-chlorophenol 28/28

MATERIAL SAFETY DATA SHEET GLYCERIN MSDS

Section 1 : Chemical Product and Company Identification

Product name : Glycerin Contact Information : Catalog codes : SLG 1171, SLG1894, SLG1111, SLG1615 PT.DUA KUDA INDONESIA CAS#: 56-81-5 JL. MADIUN BLOK C2.11-C2.13 RTECS: MA8050000 UNIT USAHA KAWASAN MARUNDA TSCA 8 (b) inventory: Glycerin JAKARTA-UTARA 14120 CI#: Not Available PHONE : +62-21-44852388 Synonim: 1,2,3 – Propanetriol; Glycerol Chemical Name : Glycerin Chemical Formula: C3H5 (OH)3

Section 2: Composition and Information on Ingredients

Composition :

Name CAS # %by Weight

Glycerin 56-81-5 100

Toxocological Data on Ingredients : Glycerin: ORAL (LD50): Acute: 12600mg/kg (Rat). 4090 mg/kg (Mouse). DERMAL (LD50): Acute: 10000 mg/kg (Rabbit). MIST (LC50): Acute: > 570 mg/m a hours (Rat)

Section 3 : Hazards Identification

Potential Acute Health Effects: Slightly hazardous in case of skin contact (irritant,permeator), of eye contact (irritant), of ingestion, of inhalation.

Potential Chronic Health Effects:

CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS:Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance may be toxic to kidneys. Repeated or prolonged exposure to the substance can produce target organs damage.

Section 4 : First Aid Measures Eye Contact : Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention if irritation occurs.

Skin Contact : Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold water may be used. Serious Skin Contact : Not available

Inhalation : If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention immediately. Serious Inhalation: Not available.

Ingestion: Do not induce vomiting unlessdirected to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention immediately .

Serious inhalation: Not available

Ingestion : Do not induce vomiting unless directed to do so by medical personnel. Never give anything bu mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear.

Serious Ingestion : Not available.

Section 5 : Fire and Explosion Data Flammability of the Product : May be combustible at high temperature

Auto-Ignition Temperature : 370:C (698:F)(NFPA Fire Protection Guide to Hazardous Materials, 13th ed., 2002; NIOSH ICSC, 2001; CHRIS,2001)392 C (739 F) (Lewis, 1997)

Flash Points:

CLOSED CUP: 160:C (320:F).(Chemical Hazard Response Information System,2001;Lewis,1997). OPEN CU: 177:C (350.6:F)(Budavari,2000; Chemical Response Information System,2001; niosh icsc,2001) OPEN CUP: 199:C (390F) (National Fire Protection Association,Fire Protection Association,Fire Protection Guide to HazardousMaterials,13 ed., 2002)

Flammable Limits : LOWER: 0.9%

Products of Combustion: These products are products are carbon oxides (CO,CO2), irritating and toxic fumes.

Fire Hazards in Presence of Various Substances: Slightly flammable to flammable in presence of open flames and sparks, of heat, of oxidizing materials. Non-flammable in presence of shocks.

Explosion Hazards in presence of various substances: Risk of explosion of the product in presence of mechanical impact: Not available. Risk of explosion of the product in presence of static discharge: Not available. Explosive in precense of oxidizing materials.

Fire Fighting Media and Instructions : SMALL FIRE: Use Dry chemical powder. LARGE FIRE: use water spray, fog or foam. Do not use water jet.

Special Remarks on fire Hazards: Not available.

Special Remarks on Explosion Hazards: Glycerin is incompatible with strong oxidizers such as chromium trioxide, potassium chlorate, or potassium permanganate and may explode on contact with these compounds. Explosive glyceryl nitrate is formed from a mixture of glycerin and nitric and sulfuric acids. Perchloric acid, lead oxide + glycerin form perchloric esters which may be explosive. Glycerin and chlorine may explode if heated and confined.

Section 6 : Accidential Release Measures

Small Spill: Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.

Large Spill: Stop leak if without risk. If the product is in its solid form: use a hovel to put the material into a convenient waste disposal container. If the product is in its liquid form: do not get water inside container.Absorb with an inert material and put the spilled material in an appropriate waste disposal. Do not touch spilled material. Use water spray to reduce vapors. Prevent entry into sewers, basement or confined areas;dike if needed. Elimination all ignition sources. Call for assistance on disposal. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Be careful that the product is not present at a concertration level above TLV.Check TLV on the MSDS and with local authorities.

Section 7: Handling and storage Precautions : Keep away from heat. Keep away from sources of ignition.Ground all equipment containing material. Do not ingest.Do not breathe gas/fumes/vapor/spray. Wear suitable protective clothing. If ingested,seek medical advice immediately and show the container or the label. Keep away from incompatibles such as oxidizing agents.

Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area. Hygroscopic

Section 8: Exposure Controls/ Personal Protection

Personal Protection:

Safety glasses. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.

Personal Protection in case of a Large Spill: Splash goggles.full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product.

Exposure Limits: TWA: 10 (mg/m3) from ACGIH (TLV) (United States) (1999) Inhalation Total. TWA: 10 STEL:20 (mg/m3)(Canada) TWA:10 STEL:20 (mg/m3) (Canada)TWA: 5 (mg/m3) from OSHA (PEL) (United States) Inhalation Respirable. Consult local authorities for acceptable exposure limits.

Section 9: Physical and Chemical Properties Physical state and appearance : Liquid (viscous (Syrupy)liquid)

Odor: Mild

Taste: Sweet

Molecular Weight: 92.09 g/mole

Color : Clear Colorless

PH (1% soln/water): Not available

Boiling Point: 290:C (554:F)

Melting Point: 19:C (66.2:F)

Critical Temperature: Not available

Specific Gravity : 1.2636 (water = 1)

Vapor Pressure: 0 kPa (@20:C)

Vapor Density: 3.17 (Air=1)

Volatility : Not available

Water/Oil DistCoeff: The product is more soluble in water; log (oil/water)=-1.8

Ionicity (in water): Not available

Dispersion Properties: See solubility in water, acetone

Solubility: Miscible in cold water, hot water and alcohol.Partially soluble in acetone. Very slightly soluble in diethyl ether (ethyl ether). Limited solubility in ethyl acetate. Insoluble in carbon tetrachloride,benzene,chloroform,petroleum ethers ,and oils.

Section 10: Stability and Reactivity Data

Stability : The product is stable

Instability Temperature : Not Available

Conditions of Instability : avoid contact with incompatible materials, excess heat and ignition, sources, moisture.

Incompatibility with various substances: Highly reactive with oxidizing agents

Corrosivity : non-corrosive in presence of glass

Special Remarks on Reactivity: Hygroscopic. Glycerin is incompatible with strong oxiders such as chromium trioxide, potassium chlorate, or potassium permanganate. Glycerin may react violently with acetic anhydride, aniline and nitrobenzene, chromic oxide, lead oxide and fluorine, phosphorous triodide, ethylene oxide and heat, silver prechlorate, sodium peroxide, sodium hydride.

Special Remarks on Corrosivity : Not available

Polumerization: will not occur

Section 11: Toxicological Information

Routes of Entry: Absorbed through skin. Eye contact

Toxicity to Animals: WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oral toxicity (LC50): 4090 mg/kg (Mouse). Acute dermal toxicity of the mist (LC50): > 570 mg/m3 1 hours (Rat).

Chronic Effects on Humans: May cause damage to the following organs: kidneys

Other Toxic Effects on Humans : Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.

Special Remarks on Toxicity to Animals :

TDL (rat) –Route: Oral;dose: 100 mg/kg 1 day prior to mating. TDL (human) – Route: Oral; Dose: 1428 mg/kg

Special Remarks on other Toxic Effects on Humans: Acute Potensial Health Effects: Low hazards for normal industrial or normal workplace conditions. Skin: May cause skin irritation. May be absorbed through skin eyes: may cause eye irritation with stinging redness, burning sensation, and tearing, but no eye injury. Ingestion: low hazards. Low toxicity except with very large doses. When large doses are ingested , it can cause gastrointestinal tract irritation with thirst (dehydration),nausea or vomiting diarrhea. It may also affect behavior/central nervous system/nervious system (central nervous system depression, general anesthetic, headache,dizziness, confusion, insomnia, toxic psychosis, muscle weakness, paralysisconvulsions), urinary system/kidneys ( renal failure,hemoglobinuria),

Cardiovascular system ( cardiac arrhythmias), liver. It may also cause elevated blood sugar. Inhalation: due to low vapor pressure, inhalation of the vapors at room temperature is unlikely.

Inhalationof mist may cause respiratory tract irritation. Chronic potential health effects: ingestion: prolonged or repeated ingestion may affect the blood (hemolysis, changes in white blood cell count), endocrine system ( Change in adneral weight), respiratory system, and may cause kidney injury.

Section 12 : Ecological Information

Ecotoxicity: Ecotoxicity in water (LC50): 58.5 ppm 96 hours (Trout)

BOD5 and COD : Not Available

Products of Biodegradation: Possibly hazardous short term degradation products are not likely. How ever, long term degradation products may arise.

Toxicity of the products of Biodegradation: The products of degradation products are less toxic than the product itself.

Special Remarks on the products of Biodegration: not available

Section 13: Disposal Consierations

Waste Disposal: Waste must be disposed of in accordance with federal, state and local environmental control regulations.

Section 14: Transport Information

DOT Classification: Not a DOT controlled material ( United States ).

Identification : Not applicable

Special Provisions for Transport: Not applicable

Section 15: Other Regulatory Information

Federal and state Regulations : Ilinois toxic substances disclosure to employee act : Glycerin Rhode Islan RTK hazardous substances: Glycerin Pennsylvania RTK: Glycerin Minnesota: Glycerin Massachusetts RTK: Glycerin Tenessee- Hazardous Right to know: Glycerin TSCA 8(B) Inventory: Glycerin.

Other Regulations: OSHA: Hazardous by definition of hazards communication stacdard (29 CFR 1910.1200). EINECS:

This product is on the European inventory of existing Commercial Chemical Substances.

Other Classifications :

WHMIS (Canada): Not controlled under WHMIS (Canada ).

DSCL (EEC) : Not available S24/25- Avoid contact with skin and eyes.

HMIS (U.S.A): Health Hazards: 1 Fire Hazards: 1 Reactivity : 0 Personal Protection: g

National Fire Protection Association (U.S.A): Health : 1 Flammability : 1 Reactivity: 0 Specific hazards:

Protective Equipment :

Gloves. Lab coat. Vapor respirator. Be sure to use an approved/ certified respirator or equipvalent. Wear appropriate respirator when ventilation is inadequate. Safety glasses.

MATERIAL SAFETY DATA SHEET - MSDS Sulfuric Acid (Concentrated)

Martin Product Sales, LLC Emergency Assistance P.O. Box 191 Chemtrec: (800)424-9300 Kilgore, Texas 75663 1-800-256-6644

Section 1: Product Identification

Synonyms: Sulphuric Acid, Hydrogen Sulphate, Oil of Vitriol, Battery Acid Chemical Name: Sulfuric Acid Chemical Family: Inorganic Acid Chemical Formula: H2SO4 CAS Reg. No.: 7664-93-9

Martin can not guarantee the technical analysis and exact chemical composition as it may vary depending on the chemical components of the raw material and are not reflected in this document. Consult analysis sheets for exact chemical composition.

Section 2: Hazard Identification

PHYSICAL STATE AND APPEARANCE: Odorless, clear to amber, heavy, oily liquid. A pungent odor may exist if certain impurities are present in the acid.

EMERGENCY OVERVIEW: Danger! Extremely corrosive. Causes severe burns and / or eye damage. Mist: Causes respiratory irritation. Harmful if inhaled. Harmful or fatal if swallowed. Reacts violently with water. Concentrated Sulfuric Acid will react with many organic materials and may cause fire due to the heat of the reaction. Not flammable, but reacts with most metals to form explosive/flammable hydrogen gas.

This product contains ingredients that are considered to be hazardous as defined by the OSHA Hazard Communication Standard 29 CFR 1910.1200, and is listed in the Toxic Substances Control Act (TSCA).

Routes of entry: Skin contact. Eye contact. Ingestion. Inhalation.

Potential acute health effects EYE CONTACT: Immediate pain, severe burns and corneal damage, which may result in permanent blindness.

SKIN CONTACT: Causes burns, and brownish or yellow stains. Concentrated solutions may cause second or third degree burns with severe necrosis. Prolonged and repeated exposure to dilute solutions may cause irritation, redness, pain and drying and cracking of the skin.

INHALATION: Causes respiratory irritation and at high concentrations may cause severe injury, burns, or death. Effects of exposure may be delayed.

INGESTION: Causes severe irritation or burns of the mouth, throat, and esophagus.

Sulfuric Acid 1 August 2009 EXISTING MEDICAL CONDITIONS POSSIBLY AGGRAVATED BY EXPOSURE: Skin irritation may be aggravated in individuals with existing skin lesions. Breathing of vapors or sprays (mists) may aggravate acute or chronic asthma and chronic pulmonary disease such as emphysema and bronchitis.

See Section 11 for Toxicological Data

Section 3: Composition / Information on Ingredients

Name CAS # % by weight Sulfuric Acid 7664-93-9 70 – 100% Water 7732-18-5 0-30%

Section 4: First Aid Measures

Corrosive effects on the skin and eyes may be delayed, and damage may occur without the sensation or onset of pain. SPEED IS ESSENTIAL. OBTAIN IMMEDIATE MEDICAL ATTENTION. Have emergency eyewash station / safety shower available in work area.

SKIN CONTACT: Immediately flush skin with running water for a minimum of 20 minutes. Start flushing while removing contaminated clothing. If irritation persists, repeat flushing. Obtain medical attention immediately. Do not transport victim unless the recommended flushing period is completed or flushing can be continued during transport.

Discard heavily contaminated clothing and shoes in a manner that limits further exposure.

EYE CONTACT: Immediately flush eyes with running water for a minimum of 20 minutes. Hold eyelids open during flushing. If irritation persists, repeat flushing. Obtain medical attention IMMEDIATELY. Do not transport victim until the recommended flushing period is completed unless flushing can be continued during transport.

INHALATION: Move victim to fresh air. Give artificial respiration ONLY if breathing has stopped. Do not use mouth-to-mouth method if victim ingested or inhaled the substance: induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Give Cardiopulmonary Resuscitation (CPR) if there is no pulse AND no breathing. Obtain medical attention IMMEDIATELY.

INGESTION: DO NOT INDUCE VOMITING. If victim is alert and not convulsing, rinse mouth and give ½ to 1 glass of water to dilute material. If spontaneous vomiting occurs, have victim lean forward with head down to avoid breathing in of vomitus, rinse mouth and administer more water. IMMEDIATELY contact local poison control center. Vomiting may need to be induced but should be directed by a physician or a poison control centre. IMMEDIATELY transport victim to an emergency facility.

While the patient is being transported to a medical facility apply compresses of iced water. If medical treatment must be delayed, immerse the affected area in iced water or apply compresses of iced water to affected areas. Do not freeze tissue.

Continued washing of the affected area with cold or iced water will be helpful in removing the last traces of sulfuric acid. Creams or ointments should not be applied before or during the washing phase of treatment.

Sulfuric Acid 2 August 2009 NOTE TO PHYSICIANS: This product contains materials that may cause severe pneumonitis if aspirated. If ingestion has occurred less than 2 hours earlier, carry out careful gastric lavage; use endotracheal cuff if available, to prevent aspiration. Observe patient for respiratory difficulty from aspiration pneumonitis. Give artificial resuscitation and appropriate chemotherapy if respiration is depressed. Following exposure the patient should be kept under medical review for at least 48 hours as delayed pneumonitis may occur. DO NOT attempt to neutralize the acid with weak bases since the reaction will produce heat that may extend the corrosive injury

Section 5: Fire Fighting Measures

Flammability of the product: Non-flammable Flash points: Not applicable Auto-ignition temperature: Not applicable Flammable limits: Not applicable Products of thermal decomposition: Oxides of Sulfur EXPLOSION HAZARDS: Not flammable but highly reactive. Reacts violently with water with evolution of heat can react with organic materials explosively (See Section 10). Reacts with many metals to liberate hydrogen gas which can form explosive mixtures with air. Hydrogen can accumulate to explosive concentrations. May ignite other combustible materials.

HAZARDOUS REACTIVITY Instability: Stable, but reacts violently with water and organic materials with evolution of heat.

Decomposition: Releases sulfur dioxide at extremely high temperatures.

Polymerization: Polymerization will not occur.

Materials to Avoid: Vigorous reactions with water; alkaline solutions; metals, metal powder; carbides; chlorates; fuminates; nitrates; picrates; strong oxidizing, reducing, or combustible organic materials. Hazardous gases are evolved on contact with chemicals such as cyanides, sulfides, and carbides.

FIRE-FIGHTING MEDIA AND INSTRUCTIONS: Wear a NIOSH/MSHA approved self-contained breathing apparatus if vapors or mists are present and full protective clothing. For fighting fires in close proximity to spill or vapors, use acid-resistant personal protective equipment. Evacuate personnel to a safe area. Prevent unauthorized entry to fire area. Dike area to contain runoff and prevent contamination of water sources. Neutralize runoff with lime, soda ash or other suitable neutralizing agents (see Deactivating Chemicals, Section 6). Cool containers that are exposed to flame with streams of water until fire is out.

Sulfuric Acid 3 August 2009 Section 6: Accidental Release Measures

Small Spill: Cover with DRY earth, sand or other non-combustible material or absorb with an inert dry material and place in a loosely covered plastic or other appropriate waste disposal container. If necessary: Neutralize the residue with a dilute solution of sodium carbonate, lime, or other suitable neutralizing agent.

Large Spill: Stop leak if possible without risk. Dike with DRY earth, sand or other non-combustible inert material. Prevent entry into sewers or waterways. Consider neutralizing the residue with sodium carbonate, lime, or other suitable neutralizing agent. Ensure adequate decontamination of tools and equipment following clean up. Comply with Federal, Provincial/State and local regulations on reporting releases. Dispose of waste material at an approved waste treatment/disposal facility, in accordance with applicable regulations. Do not dispose of waste with normal garbage or to sewer systems.

Section 7: Handling and Storage

Good general ventilation should be provided to keep vapor and mist concentrations below the exposure limits. Have available and wear as appropriate: Chemical splash goggles; full-length faceshield/chemical splash goggle combination; acid-proof gauntlet gloves, apron, and boots; acid proof suit and hood; and appropriate NIOSH/MSHA respiratory protection. In case of emergency or where there is a strong possibility of considerable exposure, wear a complete acid suit with hood, boots and gloves. If acid vapor or mist are present and exposure limits may be exceeded, wear appropriate NOISH/MSHA respiratory protection.

HANDLING: Wear appropriate Personal Protection Equipment. Do not breathe sprays or mists. Do not ingest. Do not get in eyes, on skin or on clothing. Keep ignition sources away from sulfuric acid storage, handling and transportation equipment. Locate safety shower and eyewash station close to chemical handling area. Use EXTREME care when diluting with water. Always add acid to water never the reverse. CAUTION: Hydrogen, a highly flammable gas, can accumulate to explosive concentrations inside drums, or any types of steel containers or tanks upon storage. Carbon steel storage tanks must be vented. People working with this chemical should be properly trained regarding its hazards and its safe use.

STORAGE: If stored in non-reactive container, keep container tightly closed. Metal and, specifically carbon steel, storage tanks must be vented due to hydrogen release as noted above.

Section 8: Exposure Control / Personal Protection

Engineering controls Use process enclosures, local exhaust ventilation or other engineering controls to keep airborne levels below recommended exposure limits. The most effective measures are the total enclosure of processes and the mechanization of handling procedures to prevent all personal contact with sulfuric acid. Safety showers and eyewash stations should be installed in storage and handling areas.

Personal protection Eyes: Chemical goggles and face shield.

Skin: Where there is a danger of spilling or splashing, acid resistant aprons or suits should be worn. Trouser legs should be worn outside (not tucked in) rubber boots.

Hands: Chemical-resistant, impervious gloves (i.e. neoprene) should be worn when handling sulfuric acid.

Sulfuric Acid 4 August 2009 Respiratory: Respirator selection must be based on known or anticipated exposure levels, the hazards of the product and the safe working limits of the selected respirator. A NIOSH/MSHA approved air-purifying 3 respirator equipped with acid gas/fume, dust, mist cartridges for concentrations up to 10 mg/m . An air- supplied respirator if concentrations are higher or unknown.

NOTE: Personal protection information shown in Section 8 is based upon general information as to normal uses and conditions. Where special or unusual uses or conditions exist, it is suggested that the expert assistance of an industrial hygienist or other qualified professional be sought.

Component Exposure limits 3 Sulfuric Acid: ACGIH TLV 1 mg/m (TWA) 8 hours 3 ACGIH STEL 3 mg/m 15 minutes 3 OSHA PEL 1 mg/m (TWA) 8 hours 3 NIOSH REL 1 mg/m (TWA) 10 hours

Section 9: Physical and Chemical Properties

Appearance and Odor: Odorless, clear to amber, heavy, oily liquid. A pungent odor may exist if certain impurities are present in the acid.

Physical State: Liquid Molecular Weight: 98.08 Odor Threshold: Not applicable Boiling Point: 78%: 193°C (380°F) 93%: 276°C (529°F) 98%:330°C (626°F) Melting/Freezing Point: 78%: -11.2°C (+11.6°F) 93%: -29.5°C (-21.1°F) 98%: -1.1°C (30°F) Vapor Pressure at 40°C (102°F): 78%: 1.2 mmHg 93%: 0.0016 mmHg 98%: 0.002 mmHg Specific Gravity at 15°C (60°F): 78%: 1.7059 93%: 1.8354 98%: 1.8437 Vapor Density: (Air=1): 3.4 Evaporation Rate: Not applicable Solubility: Easily soluble in cold water (with liberation of much heat.) Soluble in ethyl alcohol. pH: 0.3 (1N solution at 25°C/78°F)

Section 10: Stability and Reactivity

Stability: Stable

Conditions to Avoid: Keep away from heat and sources of ignition. Avoid temperatures, which may have a negative effect on the materials of construction used in equipment.

Materials to Avoid: Contact with organic materials (such as alcohol, acrylonitrile, chlorates, carbides, epichlorohydrin, fulminates, isoprene, nitrates and picrates) may cause fire and explosions. Contact with metals may produce flammable hydrogen gas. When diluting, add acid to water. Do NOT add water to the acid.

Sulfuric Acid 5 August 2009 Hazardous Decomposition or Combustion Products: Toxic gases and vapors (e.g. sulfur dioxide, sulfuric acid vapors/mists and sulfur trioxide) may be released when sulfuric acid decomposes.

Hazardous Polymerization: Will Not Occur.

Corrosivity: Extremely corrosive in presence of aluminum, copper, and stainless steel. Highly corrosive in presence of stainless steel (304). Non-corrosive in presence of glass.

Section 11: Toxicological Information Toxicity Data

3 LD (oral, rat) = 2140 mg/kg LC (inhalation, rat) = 510 mg/m for 2 hrs 50 50

Carcinogenicity Data: The IARC has concluded that occupational exposure to strong inorganic acid mists containing sulfuric acid is carcinogenic to man, causing cancer of the larynx (the voice box). Although no direct link has been established between exposure to sulfuric acid and cancer in man, exposure to any mist or aerosol during the use of this product should be avoided.

Reproductive Effects: Slightly embryotoxic in rabbits (a minor, rare skeletal variation). The animals were 3 exposed to 5 and 20 mg/m for 7 hrs/day throughout pregnancy. Slight maternal toxicity was present at the highest dose in both species.

Mutagenicity Data: Cytogenic analysis (hamster) ovaries 4 mmol/L

Teratogenicity Data: Not teratogenic in mice and rabbits.

Synergistic Materials: None known

Special Remarks on other Toxic Effects on Humans: Skin: Causes severe skin irritation and burns. Continued contact can cause tissue necrosis.

Eye: Causes severe eye irritation and burns. May cause irreversible eye injury.

Ingestion: Harmful if swallowed. May cause permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause perforation of the stomach, GI bleeding, edema of the glottis, necrosis and scarring, and sudden circulatory collapse (similar to acute inhalation). It may also cause systemic toxicity with acidosis.

Inhalation: May cause severe irritation of the respiratory tract and mucous membranes with sore throat, coughing, shortness of breath, and delayed lung edema. Causes chemical burns to the respiratory tract. Inhalation may be fatal as a result of spasm, inflammation, edema of the larynx and bronchi, chemical pneumonitis, and pulmonary edema. May also affect teeth (changes in teeth and supporting structures - erosion, discoloration).

Sulfuric Acid 6 August 2009 Chronic Potential Health Effects:

Inhalation: Prolonged or repeated inhalation may affect behavior (muscle contraction or spasticity), urinary system (kidney damage), and cardiovascular system, heart (ischemic heart lesions), and respiratory system/lungs (pulmonary edema, lung damage), teeth (dental discoloration, erosion).

Skin: Prolonged or repeated skin contact may cause dermatitis, an allergic skin reaction.

Section 12: Ecological Information

Ecotoxic Effects: Harmful to aquatic life in very low concentrations. May be dangerous if it enters water intake; Fish toxicity; 2.8 μg/L 96 hrs LC50 Rainbow trout.

Products of Degradation: Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. These products are sulphur oxides (SO2, SO3)

Toxicity of the Products of Degradation: The products of degradation are more toxic than the original product.

Section 13: Disposal Considerations

Waste disposal: The generation of waste should be avoided or minimized wherever possible. Cleaned up material may be a hazardous waste as defined by Resource Conservation and Recovery Act (RCRA) on disposal due to the corrosivity characteristic. Disposal of this product and any by-products must comply with all local, state, and federal requirements. Consult your local and/or regional authorities.

Section 14: Transport Information

Shipping Description: Sulfuric Acid Shipping Description: UN 1830, Sulfuric Acid, 8, PG II Packaging References: 49CFR, Sections 172.504, 173.213, 173.247, 172.325 / SP 30

Section 15: Regulatory Information

U.S. Federal regulations:

TSCA 8(b) inventory: Sulfuric acid SARA 302/304/311/312 extremely hazardous substances: Sulfuric acid SARA 313 toxic chemical notification and release reporting: Sulfuric acid CERCLA: Hazardous Substances: Sulfuric acid: 1000 lbs. (453.6 kg)

Reportable Quantity (RQ) under U.S. EPA CERCLA: RQ=1000 lb / 454 kg TSCA Inventory Status: Reported/Included

Other Regulations/Legislation which apply to this product: New Jersey Special Health Hazard Substance List and Environmental Hazardous Substance; Minnesota, Florida, Rhode Island Hazardous Substance ; California Director's List of Hazardous Substances; Massachusetts Extraordinarily Hazardous Substance List

Sulfuric Acid 7 August 2009

Section 16: Other Information Hazardous Material Information System (HMIS) National Fire Protection Association (NFPA)

3 Health

0 Fire hazard 2 Physical Hazard C Personal protection

References: 29 CFR Part 1910.1200 OSHA MSDS Requirements. 49 CFR 172.101 Table of Hazardous Materials ANSI Z400.1, MSDS Standard, 2004. Hawley’s Condensed Chemical Dictionary, 14th Edition The Merck Index, 12th Edition Supplier Material Safety Data Sheets

LEGAL DISCLAIMER

While the information contained in the MSDS is believed to be reliable, no guarantee is made as to its accuracy or completeness. The conditions of use, handling, storage, and disposal, and the suitability of the product for particular uses are beyond our control. Consequently, all risks involving the use of the product are assumed by the user. We expressly disclaim all warranties of every kind and nature, express or implied, including the warranties of merchantability and fitness for a particular purpose.

Sulfuric Acid 8 August 2009 He a lt h 3 2 Fire 2 3 0 Re a c t iv it y 0 Pe rs o n a l Pro t e c t io n H Material Safety Data Sheet Acetic acid MSDS

Section 1: Chemical Product and Company Identification

Product Name: Acetic acid Contact Information: Catalog Codes: SLA3784, SLA1438, SLA2101, SLA3604, Sciencelab.com, Inc. SLA1258 14025 Smith Rd. Houston, Texas 77396 CAS#: 64-19-7 US Sales: 1-800-901-7247 RTECS: AF1225000 International Sales: 1-281-441-4400 TSCA: TSCA 8(b) inventory: Acetic acid Order Online: ScienceLab.com CI#: Not applicable. CHEMTREC (24HR Emergency Telephone), call: 1-800-424-9300 Synonym: Acetic acid; glacial acetic acid International CHEMTREC, call: 1-703-527-3887 Chemical Name: Acetic Acid, Glacial For non-emergency assistance, call: 1-281-441-4400 Chemical Formula: C2-H4-O2

Section 2: Composition and Information on Ingredients

Composition:

Name CAS # % by Weight Acetic acid 64-19-7 100

Toxicological Data on Ingredients: Acetic acid: ORAL (LD50): Acute: 3310 mg/kg [Rat]. 4960 mg/kg [Mouse]. 3530 mg/kg [Rat]. DERMAL (LD50): Acute: 1060 mg/kg [Rabbit]. VAPOR (LC50): Acute: 5620 ppm 1 hours [Mouse].

Section 3: Hazards Identification

Potential Acute Health Effects: Very hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Hazardous in case of skin contact (corrosive, permeator), of eye contact (corrosive). Liquid or spray mist may produce tissue damage particularly on mucous membranes of eyes, mouth and respiratory tract. Skin contact may produce burns. Inhalation of the spray mist may produce severe irritation of respiratory tract, characterized by coughing, choking, or shortness of breath. Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering. Potential Chronic Health Effects: Hazardous in case of skin contact (irritant), of ingestion, of inhalation. CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance may be toxic to kidneys, mucous membranes, skin, teeth. Repeated or prolonged exposure to the substance can produce target organs damage. Repeated

p. 1 or prolonged contact with spray mist may produce chronic eye irritation and severe skin irritation. Repeated or prolonged exposure to spray mist may produce respiratory tract irritation leading to frequent attacks of bronchial infection.

Section 4: First Aid Measures

Eye Contact: Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention immediately. Skin Contact: In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Cover the irritated skin with an emollient. Cold water may be used.Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention immediately. Serious Skin Contact: Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medical attention. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention immediately. Serious Inhalation: Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. WARNING: It may be hazardous to the person providing aid to give mouth-to-mouth resuscitation when the inhaled material is toxic, infectious or corrosive. Seek immediate medical attention. Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear. Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: Flammable. Auto-Ignition Temperature: 463°C (865.4°F) Flash Points: CLOSED CUP: 39°C (102.2°F). OPEN CUP: 43°C (109.4°F). Flammable Limits: LOWER: 4% UPPER: 19.9% Products of Combustion: These products are carbon oxides (CO, CO2). Fire Hazards in Presence of Various Substances: Flammable in presence of open flames and sparks, of heat. Slightly flammable to flammable in presence of oxidizing materials, of metals. Explosion Hazards in Presence of Various Substances: Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in presence of static discharge: Not available. Slightly explosive in presence of oxidizing materials. Fire Fighting Media and Instructions: Flammable liquid, soluble or dispersed in water. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use alcohol foam, water spray or fog. Cool containing vessels with water jet in order to prevent pressure build-up, autoignition or explosion. Special Remarks on Fire Hazards: Reacts with metals to produces flammable hydrogen gas. It will ignite on contact with potassium-tert-butoxide. A mixture of ammonium nitrate and acetic acid ignites when warmed, especially if warmed. Special Remarks on Explosion Hazards:

p. 2 Acetic acid vapors may form explosive mixtures with air. Reactions between acetic acid and the following materials are potentially explosive: 5-azidotetrazole, bromine pentafluoride, chromium trioxide, hydrogen peroxide, potassium permanganate, sodium peroxide, and phorphorus trichloride. Dilute acetic acid and dilute hydrogen can undergo an exothermic reaction if heated, forming peracetic acid which is explosive at 110 degrees C. Reaction between chlorine trifluoride and acetic acid is very violent, sometimes explosive.

Section 6: Accidental Release Measures

Small Spill: Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container. If necessary: Neutralize the residue with a dilute solution of sodium carbonate. Large Spill: Flammable liquid. Corrosive liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. If the product is in its solid form: Use a shovel to put the material into a convenient waste disposal container. If the product is in its liquid form: Absorb with DRY earth, sand or other non-combustible material. Do not get water inside container. Absorb with an inert material and put the spilled material in an appropriate waste disposal. Do not touch spilled material. Use water spray curtain to divert vapor drift. Prevent entry into sewers, basements or confined areas; dike if needed. Call for assistance on disposal. Neutralize the residue with a dilute solution of sodium carbonate. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities.

Section 7: Handling and Storage

Precautions: \Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do not breathe gas/fumes/ vapor/spray. Never add water to this product. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin and eyes. Keep away from incompatibles such as oxidizing agents, reducing agents, metals, acids, alkalis. Storage: Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed and sealed until ready for use. Avoid all possible sources of ignition (spark or flame).

Section 8: Exposure Controls/Personal Protection

Engineering Controls: Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respective threshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location. Personal Protection: Splash goggles. Synthetic apron. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves (impervious). Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure Limits: TWA: 10 STEL: 15 (ppm) [Australia] TWA: 25 STEL: 27 (mg/m3) [Australia] TWA: 10 STEL: 15 (ppm) from NIOSH TWA: 25 STEL: 37 (mg/m3) from NIOSH TWA: 10 STEL: 15 (ppm) [Canada] TWA: 26 STEL: 39 (mg/m3) [Canada] TWA: 25 STEL: 37 (mg/m3) TWA: 10 STEL: 15 (ppm) from ACGIH (TLV) [United States] [1999] TWA: 10 (ppm) from OSHA (PEL) [United States] TWA: 25 (mg/m3) from OSHA (PEL) [United States]Consult local authorities for acceptable exposure limits.

Section 9: Physical and Chemical Properties

p. 3 Physical state and appearance: Liquid. Odor: Pungent, vinegar-like, sour (Strong.) Taste: Vinegar, sour (Strong.) Molecular Weight: 60.05 g/mole Color: Colorless. Clear (Light.) pH (1% soln/water): 2 [Acidic.] Boiling Point: 118.1°C (244.6°F) Melting Point: 16.6°C (61.9°F) Critical Temperature: 321.67°C (611°F) Specific Gravity: 1.049 (Water = 1) Vapor Pressure: 1.5 kPa (@ 20°C) Vapor Density: 2.07 (Air = 1) Volatility: Not available. Odor Threshold: 0.48 ppm Water/Oil Dist. Coeff.: The product is more soluble in water; log(oil/water) = -0.2 Ionicity (in Water): Not available. Dispersion Properties: See solubility in water, diethyl ether, acetone. Solubility: Easily soluble in cold water, hot water. Soluble in diethyl ether, acetone. Miscible with Glycerol, alcohol, Benzene, Carbon Tetrachloride. Practically insoluble in Carbon Disulfide.

Section 10: Stability and Reactivity Data

Stability: The product is stable. Instability Temperature: Not available. Conditions of Instability: Heat, ignition sources, incompatible materials Incompatibility with various substances: Reactive with oxidizing agents, reducing agents, metals, acids, alkalis. Corrosivity: Highly corrosive in presence of stainless steel(304). Slightly corrosive in presence of aluminum, of copper. Non-corrosive in presence of stainless steel(316). Special Remarks on Reactivity: Reacts violently with strong oxidizing agents, acetaldehyde, and acetic anhydride. Material can react with metals, strong bases, amines, carbonates, hydroxides, phosphates, many oxides,cyanides, sulfides, chromic acid, nitric acid, hydrogen peroxide, carbonates. ammonium nitrate, ammonium thiosulfate, chlorine trifluoride, chlorosulfonic acid, perchloric acid, permanganates, xylene, oleum, potassium hydroxide, sodium hydroxide, phosphorus isocyanate, ethylenediamine, ethylene imine. Special Remarks on Corrosivity: Moderate corrosive effect on bronze. No corrosion data on brass Polymerization: Will not occur.

Section 11: Toxicological Information

Routes of Entry: Absorbed through skin. Dermal contact. Eye contact. Inhalation. Ingestion.

p. 4 Toxicity to Animals: WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oral toxicity (LD50): 3310 mg/kg [Rat]. Acute dermal toxicity (LD50): 1060 mg/kg [Rabbit]. Acute toxicity of the vapor (LC50): 5620 1 hours [Mouse]. Chronic Effects on Humans: MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast. May cause damage to the following organs: kidneys, mucous membranes, skin, teeth. Other Toxic Effects on Humans: Extremely hazardous in case of inhalation (lung corrosive). Very hazardous in case of skin contact (irritant), of ingestion, . Hazardous in case of skin contact (corrosive, permeator), of eye contact (corrosive). Special Remarks on Toxicity to Animals: Not available. Special Remarks on Chronic Effects on Humans: May affect genetic material and may cause reproductive effects based on animal data. No human data found. Special Remarks on other Toxic Effects on Humans: Acute Potential Health Effects: Skin: Extremely irritating and corrosive. Causes skin irritation (reddening and itching, inflammation). May cause blistering , tissue damage and burns. Eyes: Extremely irritating and corrosive. Causes eye irritation, lacrimation, redness, and pain. May cause burns, blurred vision, conjunctivitis, conjunctival and corneal destruction and permanent injury. Inhalation: Causes severe respiratory tract irritation. Affects the sense organs (nose, ear, eye, taste), and blood. May cause chemical pneumonitis, bronchitis, and pulmonary edema. Severe exposure may result in lung tissue damage and corrosion (ulceration) of the mucous membranes. Inhalation may also cause rhinitis, sneezing, coughing, oppressive feeling in the chest or chest pain, dyspnea, wheezing, tachypnea, cyanosis, salivation, nausea, giddiness, muscular weakness. Ingestion: Moderately toxic. Corrosive. Causes gastrointestinal tract irritation (burning and pain of the mouth, throat, and abdomen, coughing, ulceration, bleeding, nausea, abdomial spasms, vomiting, hematemesis, diarrhea. May Also affect the liver (impaired liver function), behavior (convulsions, giddines, muscular weakness), and the urinary system - kidneys (Hematuria, Albuminuria, Nephrosis, acute renal failure, acute tubular necrosis). May also cause dyspnea or asphyxia. May also lead to shock, coma and death. Chronic Potential Health Effects: Chronic exposure via ingestion may cause blackening or erosion of the teeth and jaw necrosis, pharyngitis, and gastritis. It may also behavior (similar to acute ingestion), and metabolism (weight loss). Chronic exposure via inhalation may cause asthma and/or bronchitis with cough, phlegm, and/or shortness of breath . It may also affect the blood (decreased leukocyte count), and urinary system (kidneys). Repeated or prolonged skin contact may cause thickening, blackening, and cracking of the skin.

Section 12: Ecological Information

Ecotoxicity: Ecotoxicity in water (LC50): 423 mg/l 24 hours [Fish (Goldfish)]. 88 ppm 96 hours [Fish (fathead minnow)]. 75 ppm 96 hours [Fish (bluegill sunfish)]. >100 ppm 96 hours [Daphnia]. BOD5 and COD: BOD-5: 0.34-0.88 g oxygen/g Products of Biodegradation: Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself. Special Remarks on the Products of Biodegradation: Not available.

Section 13: Disposal Considerations

Waste Disposal: Waste must be disposed of in accordance with federal, state and local environmental control regulations.

Section 14: Transport Information

DOT Classification:

p. 5 CLASS 3: Flammable liquid. Class 8: Corrosive material Identification: : Acetic Acid, Glacial UNNA: 2789 PG: II Special Provisions for Transport: Not available.

Section 15: Other Regulatory Information

Federal and State Regulations: New York release reporting list: Acetic acid Rhode Island RTK hazardous substances: Acetic acid Pennsylvania RTK: Acetic acid Florida: Acetic acid Minnesota: Acetic acid Massachusetts RTK: Acetic acid New Jersey: Acetic acid California Director's List of Hazardous Subtances (8 CCR 339): Acetic acid TSCA 8(b) inventory: Acetic acid CERCLA: Hazardous substances.: Acetic acid: 5000 lbs. (2268 kg) Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances. Other Classifications: WHMIS (Canada): CLASS B-3: Combustible liquid with a flash point between 37.8°C (100°F) and 93.3°C (200°F). CLASS E: Corrosive liquid. DSCL (EEC): R10- Flammable. R35- Causes severe burns. S23- Do not breathe gas/fumes/vapour/spray [***] S26- In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45- In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). HMIS (U.S.A.): Health Hazard: 3 Fire Hazard: 2 Reactivity: 0 Personal Protection: H National Fire Protection Association (U.S.A.): Health: 3 Flammability: 2 Reactivity: 0 Specific hazard: Protective Equipment: Gloves (impervious). Synthetic apron. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate. Splash goggles.

Section 16: Other Information

References: Not available. Other Special Considerations: Not available. Created: 10/09/2005 03:35 PM Last Updated: 05/21/2013 12:00 PM

p. 6 no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.com has been advised of the possibility of such damages.

p. 7

Material Safety Data Sheet (MSDS) - Caustic Soda lye

1. Chemical Product and Company Identification Product Name : Caustic Soda lye Catalog Codes : SLS3298, SLS1081, SLS2503, SLS3925,SLS1705 CAS# : 1310-73-2 RTECS : WB4900000 TSCA : TSCA 8(b) inventory: Sodium hydroxide CI# : Not available. Synonym : Caustic Soda Chemical Name : Sodium Hydroxide Chemical Formula : NaOH COMPANY IDENTIFICATION Supplier: Pon Pure Chemicals Group CHENNAI, TAMILNADU, INDIA 24 Hour Health Emergency (91) 8939878447 (91) 9444038694 Transportation Emergency Phone (91) 8939768680 Company Name Place EMERGENCY TELEPHONE NUMBER Pon Pure Chemicals Group India Day Emergency – 044-26161803-26161809

2. Composition and Information on Ingredients Composition: Name CAS # % by Weight Sodium hydroxide 1310-73-2 100

Toxicological Data on Ingredients: Sodium hydroxide LD50: Not available. LC50: Not available.

3. Hazards Identification Potential Acute Health Effects: Very hazardous in case of skin contact (corrosive, irritant, permeator), of eye contact (irritant, corrosive), of ingestion, of inhalation. The amount of tissue damage depends on length of contact. Eye contact can result in corneal damage or blindness. Skin contact can produce inflammation and blistering. Inhalation of dust will produce irritation to gastro-intestinal or respiratory tract, characterized by burning, sneezing

Page 1 of 9 MSDS - Caustic Soda Lye

and coughing. Severe over-exposure can produce lung damage, choking, unconsciousness or death. Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering. Potential Chronic Health Effects: CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance may be toxic to mucous membranes, upper respiratory tract, skin, eyes. Repeated or prolonged exposure to the substance can produce target organs damage. Repeated exposure of the eyes to a low level of dust can produce eye irritation. Repeated skin exposure can produce local skin destruction, or dermatitis. Repeated inhalation of dust can produce varying degree of respiratory irritation or lung damage.

4: First Aid Measures Eye Contact: Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention immediately. Skin Contact: In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Cover the irritated skin with an emollient. Cold water may be used Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention immediately. Serious Skin Contact: Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical attention. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention immediately. Serious Inhalation: Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. WARNING: It may be hazardous to the person providing aid to give mouth-to-mouth resuscitation when the inhaled material is toxic, infectious or corrosive. Seek immediate medical attention.

Page 2 of 9 MSDS - Caustic Soda Lye

Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Serious Ingestion: Not available.

5: Fire and Explosion Data Flammability of the Product : Non-flammable. Auto-Ignition Temperature : Not applicable. Flash Points : Not applicable. Flammable Limits : Not applicable. Products of Combustion : Not available. Fire Hazards in Presence of Various Substances: metals Explosion Hazards in Presence of Various Substances: Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in presence of static discharge: Not available. Slightly explosive in presence of heat. Fire Fighting Media and Instructions: Not available Special Remarks on Fire Hazards: sodium hydroxide + zinc metal dust causes ignition of the latter. Under proper conditions of temperature, pressure and state of division, it can ignite or react violently with acetaldehyde, ally alcohol, allyl chloride, benzene-1,4-diol, chlorine trifluoride, 1,2 dichlorethylene, nitroethane, nitromethane, nitroparaffins, nitropropane, cinnamaldehyde, 2,2-dichloro-3,3-dimethylbutane. Sodium hydroxide in contact with water may generate enough heat to ignite adjacent combustible materials. Phosphorous boiled with NaOH yields mixed phosphines which may ignite spontanously in air. sodium hydroxide and cinnamaldehyde + heat may cause ignition. Reaction with certain metals releases flammable and explosive hydrogen gas. Special Remarks on Explosion Hazards: Sodium hydroxide reacts to form explosive products with ammonia + silver nitrate. Benzene extract of allyl benzenesulfonate prepared from allyl alcohol, and benzene sulfonyl chloride in presence of aquesous sodium hydroxide, under vacuum distillation, residue darkened and exploded. Sodium Hydroxde + impure tetrahydrofuran, which can contain peroxides, can cause serious explosions. Dry mixtures of sodium hydroxide and sodium tetrahydroborate liberate hydrogen explosively at 230-270 deg. C. Sodium

Page 3 of 9 MSDS - Caustic Soda Lye

Hydroxide reacts with sodium salt of trichlorophenol + methyl alcohol + trichlorobenzene + heat to cause an explosion.

6: Accidental Release Measures Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. If necessary: Neutralize the residue with a dilute solution of acetic acid. Large Spill: Corrosive solid. Stop leak if without risk. Do not get water inside container. Do not touch spilled material. Use water spray to reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Call for assistance on disposal. Neutralize the residue with a dilute solution of acetic acid. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities.

7: Handling and Storage Precautions: Keep container dry. Do not breathe dust. Never add water to this product. In case of insufficient ventilation, wear suitable respiratory equipment. If you feel unwell, seek medical attention and show the label when possible. Avoid contact with skin and eyes. Keep away from incompatibles such as oxidizing agents, reducing agents, metals, acids, alkalis, moisture. Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area. Hygroscopic. Deliquescent.

8: Exposure Controls/Personal Protection Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal Protection: Splash goggles. Synthetic apron. Vapor and dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Vapor and dust respirator. Boots. Gloves. A self contained

Page 4 of 9 MSDS - Caustic Soda Lye

breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure Limits: STEL: 2 (mg/m3) from ACGIH (TLV) [United States] TWA: 2 CEIL: 2 (mg/m3) from OSHA (PEL) [United States] CEIL: 2 (mg/ m3) from NIOSHConsult local authorities for acceptable exposure limits. 9: Physical and Chemical Properties Physical state and appearance : Solid. (Deliquescent solid.) Odor : Odorless. Taste : Not available. Molecular Weight : 40 g/mole Color : White. pH (1% soln/water) : 13.5 [Basic.] Boiling Point : 1388°C (2530.4°F) Melting Point : 323°C (613.4°F) Critical Temperature : Not available. Specific Gravity : 2.13 (Water = 1) Vapor Pressure : Not applicable. Vapor Density : Not available. Volatility : Not available. Odor Threshold : Not available. Water/Oil Dist. Coeff. : Not available. Ionicity (in Water) : Not available. Dispersion Properties : See solubility in water. Solubility : Easily soluble in cold water.

10: Stability and Reactivity Data Stability : The product is stable. Instability Temperature : Not available. Conditions of Instability : Incompatible materials, moisture, moist air Incompatibility with various substances :Highly reactive with metals. Reactive with oxidizing agents, reducing agents, acids, alkalis, moisture. Corrosivity : Not available. Special Remarks on Reactivity : Hygroscopic. Much heat is evolved when solid material is dissolved in water. Therefore cold water and caution must be used for

Page 5 of 9 MSDS - Caustic Soda Lye

this process. Sodium hydroxide solution and octanol + diborane during a work-up of a reaction mixture of oxime and diborane in tetrahyrofuran is very exothermic, a mild explosion being noted on one occassion. Reactive with water, acids (mineral, non- oxidizing, e.g. hydrochloric, hydrofluoric acid, muriatic acid, phosphoric), acids (mineral, oxidizing e.g. chromic acid, hypochlorous acid, nitric acid, sulfuric acid), acids (organic e.g. acetic acid, benzoic acid, formic acid, methanoic acid, oxalic acid), aldehydes (e.g. acetaldehyde, acrolein, chloral hydrate, foraldehyde), carbamates (e.g. carbanolate, carbofuran), esters (e.g. butyl acetate, ethyl acetate, propyl formate), halogenated organics (dibromoethane, hexachlorobenzene, methyl chloride, trichloroethylene), isocyanates (e.g. methyl isocyanate), ketones (acetone, acetophenone, MEK, MIBK), acid chlorides, strong bases, strong oxidizing agents, strong reducing agents, flammable liquids, powdered metals and metals (i.e aluminum, tin, zinc, hafnium, raney nickel), metals (alkali and alkaline e.g. cesium, potassium, sodium), metal compounds (toxic e.g. berylium, lead acetate, nickel carbonyl, tetraethyl lead), mitrides (e.g. potassium nitride, sodium nitride), nitriles (e.g. acetonitrile, methyl cyanide), nitro compounds (organic e.g. nitrobenzene, nitromethane), acetic anhydride, chlorohydrin, chlorosulfonic acid, ethylene cyanohydrin, glyoxal, hydrosulfuric acid, oleum, propiolactone, acylonitrile, phorosous pentoxide, chloroethanol, chloroform-methanol, tetrahydroborate, cyanogen azide, 1,2,4,5 tetrachlorobenzene, cinnamaldehyde. Reacts with formaldehyde hydroxide to yield formic acid, and hydrogen. Special Remarks on Corrosivity : Very caustic to aluminum and other metals in presence of moisture. Polymerization : Will not occur.

11: Toxicological Information Routes of Entry: Absorbed through skin. Dermal contact. Eye contact. Inhalation. Ingestion. Toxicity to Animals: LD50: Not available. LC50: Not available. Chronic Effects on Humans: MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. May cause damage to the following organs: mucous membranes, upper respiratory tract, skin, eyes. Other Toxic Effects on Humans: Extremely hazardous in case of inhalation (lung corrosive). Very hazardous in case of skin contact (corrosive, irritant, permeator), of eye contact (corrosive),

Page 6 of 9 MSDS - Caustic Soda Lye

of ingestion, . Special Remarks on Toxicity to Animals: Lowest Published Lethal Dose: LDL [Rabbit] - Route: Oral; Dose: 500 mg/kg Special Remarks on Chronic Effects on Humans: May affect genetic material. Investigation as a mutagen (cytogenetic analysis) Special Remarks on other Toxic Effects on Humans:

12: Ecological Information Ecotoxicity : Not available. BOD5 and COD : Not available. Products of Biodegradation : Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic. Special Remarks on the Products of Biodegradation: Not available.

13: Disposal Considerations Waste Disposal: Waste must be disposed of in accordance with federal, state and local environmental control regulations.

14: Transport Information DOT Classification : Class 8: Corrosive material Identification : Sodium hydroxide, solid UNNA: 1823 PG: II Special Provisions for Transport : Not available.

15: Other Regulatory Information Federal and State Regulations: Illinois toxic substances disclosure to employee act: Sodium hydroxide Illinois chemical safety act: Sodium hydroxide New York release reporting list: Sodium hydroxide Rhode Island RTK hazardous substances: Sodium hydroxide Pennsylvania RTK: Sodium hydroxide Minnesota: Sodium hydroxide Massachusetts RTK: Sodium hydroxide New Jersey: Sodium hydroxide Louisiana spill reporting: Sodium hydroxide California Director's List of Hazardous Substances: Sodium hydroxide TSCA 8(b) inventory: Sodium hydroxide CERCLA: Hazardous substances.: Sodium hydroxide: 1000 lbs. (453.6 kg)

Page 7 of 9 MSDS - Caustic Soda Lye

Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances. Other Classifications: WHMIS (Canada): CLASS E: Corrosive solid. DSCL (EEC):

R35- Causes severe burns. S26- In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39- Wear suitable gloves and eye/face protection. S45- In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). HMIS (U.S.A.): Health Hazard : 3 Fire Hazard : 0 Reactivity : 2 Personal Protection : j National Fire Protection Association (U.S.A.): Health : 3 Flammability : 0 Reactivity : 1 Specific hazard: Protective Equipment: Gloves. Synthetic apron. Vapor and dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate. Splash goggles.

16: Other Information

Disclaimer: The information and recommendations contained herein are, to the best of Pon Pure Chemicals Group knowledge and belief, accurate and reliable as of the date issued. You can contact Pon Pure Chemicals Group to ensure that this document is the most current available from Pon Pure Chemicals Group. The information and recommendations are offered for the user's consideration and examination. It is the user's responsibility to satisfy itself that the product is suitable for the intended use. If

Page 8 of 9 MSDS - Caustic Soda Lye

buyer repackages this product, it is the user's responsibility to insure proper health, safety and other necessary information is included with and/or on the container. Appropriate warnings and safe-handling procedures should be provided to handlers and users. Alteration of this document is strictly prohibited. Except to the extent required by law, re-publication or retransmission of this document, in whole or in part, is not permitted.

Page 9 of 9 MSDS - Caustic Soda Lye

SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 31.03.2016 Print Date 15.12.2018 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1 Product identifiers Product name : 2-Aminophenol

Product Number : A71301 Brand : Aldrich Index-No. : 612-033-00-3 REACH No. : A registration number is not available for this substance as the substance or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline. CAS-No. : 95-55-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Manufacture of substances 1.3 Details of the supplier of the safety data sheet Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 Germ cell mutagenicity (Category 2), H341 Acute toxicity, Inhalation (Category 4), H332 Acute toxicity, Oral (Category 4), H302 For the full text of the H-Statements mentioned in this Section, see Section 16. 2.2 Label elements Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Warning

Hazard statement(s) H302 Harmful if swallowed. H332 Harmful if inhaled. H341 Suspected of causing genetic defects.

Aldrich - A71301 Page 1 of 7

Precautionary statement(s) P281 Use personal protective equipment as required.

Supplemental Hazard none Statements 2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients 3.1 Substances Formula : C6H7NO Molecular weight : 109.13 g/mol CAS-No. : 95-55-6 EC-No. : 202-431-1 Index-No. : 612-033-00-3

Hazardous ingredients according to Regulation (EC) No 1272/2008 Component Classification Concentration 2-Aminophenol CAS-No. 95-55-6 Acute Tox. 4; Muta. 2; H302, <= 100 % EC-No. 202-431-1 H332, H341 Index-No. 612-033-00-3

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures 4.1 Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. 4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures 5.1 Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Aldrich - A71301 Page 2 of 7

5.2 Special hazards arising from the substance or mixture Carbon oxides, Nitrogen oxides (NOx) 5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary. 5.4 Further information No data available

SECTION 6: Accidental release measures 6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. 6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. 6.3 Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal. 6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage 7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. 7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible Solids 7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Full contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Aldrich - A71301 Page 3 of 7

Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M)

Splash contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M)

data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.

Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (EN 143) respirator cartridges as a backup to engineering controls. If th full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties 9.1 Information on basic physical and chemical properties a) Appearance Form: crystalline Colour: beige b) Odour No data available c) Odour Threshold No data available d) pH 6.5 - 7.5 at 10 g/l at 20 °C

e) Melting point/freezing Melting point/range: 170 - 175 °C - lit. point f) Initial boiling point and 164 °C at 14.9 hPa boiling range 150 °C at 1013 hPa g) Flash point 168 °C - closed cup h) Evaporation rate No data available i) Flammability (solid, gas) No data available j) Upper/lower No data available flammability or explosive limits k) Vapour pressure 14 mmHg at 153 °C l) Vapour density No data available m) Relative density 1.328 g/cm3 n) Water solubility slightly soluble o) Partition coefficient: n- log Pow: 0.52 - 0.62 octanol/water p) Auto-ignition No data available Aldrich - A71301 Page 4 of 7

temperature q) Decomposition No data available temperature r) Viscosity No data available s) Explosive properties No data available t) Oxidizing properties No data available 9.2 Other safety information Bulk density 0.6 g/l

SECTION 10: Stability and reactivity 10.1 Reactivity No data available 10.2 Chemical stability Stable under recommended storage conditions. 10.3 Possibility of hazardous reactions No data available 10.4 Conditions to avoid No data available 10.5 Incompatible materials Strong oxidizing agents, acids, Acid anhydrides, Acid chlorides, Chloroformates 10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx) Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information 11.1 Information on toxicological effects Acute toxicity LD50 Oral - Rat - 951 mg/kg(2-Aminophenol) Remarks: Behavioral:Tremor. Cyanosis Skin corrosion/irritation Serious eye damage/eye irritation Eyes - Rabbit(2-Aminophenol) Result: Mild eye irritation Respiratory or skin sensitisation No data available(2-Aminophenol) Germ cell mutagenicity

In vitro tests showed mutagenic effects(2-Aminophenol)

Carcinogenicity IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity No data available(2-Aminophenol) Specific target organ toxicity - single exposure No data available(2-Aminophenol)

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Specific target organ toxicity - repeated exposure No data available Aspiration hazard No data available(2-Aminophenol)

Additional Information RTECS: SJ4950000

To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(2-Aminophenol)

SECTION 12: Ecological information 12.1 Toxicity

Toxicity to fish LC50 - Leuciscus idus (Golden orfe) - 0.1 mg/l (2-Aminophenol)

Toxicity to daphnia and EC0 - Daphnia magna (Water flea) - 1 mg/l (2-Aminophenol) other aquatic invertebrates

EC50 - Daphnia magna (Water flea) - 35 mg/l - 24 h(2-Aminophenol) 12.2 Persistence and degradability No data available

12.3 Bioaccumulative potential No data available 12.4 Mobility in soil No data available(2-Aminophenol) 12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. 12.6 Other adverse effects

No data available

SECTION 13: Disposal considerations 13.1 Waste treatment methods Product Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chem scrubber. Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information 14.1 UN number ADR/RID: 2512 IMDG: 2512 IATA: 2512 14.2 UN proper shipping name ADR/RID: AMINOPHENOLS IMDG: AMINOPHENOLS IATA: Aminophenols 14.3 Transport hazard class(es) ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

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14.4 Packaging group ADR/RID: III IMDG: III IATA: III 14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no 14.6 Special precautions for user No data available

SECTION 15: Regulatory information 15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006. 15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information Full text of H-Statements referred to under sections 2 and 3. H302 Harmful if swallowed. H332 Harmful if inhaled. H341 Suspected of causing genetic defects. Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma- aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1 Product identifiers Product name : 2,3-Dichloroaniline

Product Number : D55407 Brand : Aldrich Index-No. : 612-010-00-8 REACH No. : A registration number is not available for this substance as the substance or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline. CAS-No. : 608-27-5 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Manufacture of substances 1.3 Details of the supplier of the safety data sheet Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 Acute toxicity (Category 3), H331 Acute toxicity (Category 3), H311 Acute toxicity (Category 3), H301 Specific target organ toxicity - repeated exposure (Category 2), H373 Acute aquatic toxicity (Category 1), H400 Chronic aquatic toxicity (Category 1), H410 For the full text of the H-Statements mentioned in this Section, see Section 16. 2.2 Label elements Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger

Hazard statement(s) H373 May cause damage to organs through prolonged or repeated exposure. Aldrich - D55407 Page 1 of 7

H301 Toxic if swallowed. H311 Toxic in contact with skin. H331 Toxic if inhaled. H410 Very toxic to aquatic life with long lasting effects.

Precautionary statement(s) P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P273 Avoid release to the environment. P280 Wear protective gloves/ protective clothing. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor. P311 Call a POISON CENTER /doctor. P501 Dispose of contents/ container to an approved waste disposal plant.

Supplemental Hazard none Statements 2.3 Other hazards - none

SECTION 3: Composition/information on ingredients 3.1 Substances Formula : C6H5Cl2N Molecular weight : 162.02 g/mol CAS-No. : 608-27-5 EC-No. : 210-157-9 Index-No. : 612-010-00-8

Hazardous ingredients according to Regulation (EC) No 1272/2008 Component Classification Concentration 2,3-Dichloroaniline CAS-No. 608-27-5 Acute Tox. 3; STOT RE 2; <= 100 % EC-No. 210-157-9 Aquatic Acute 1; Aquatic Index-No. 612-010-00-8 Chronic 1; H331, H311, H301, H373, H400, H410 M-Factor - Aquatic Acute: 10 For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures 4.1 Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician. In case of eye contact Flush eyes with water as a precaution. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. 4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 4.3 Indication of any immediate medical attention and special treatment needed No data available

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SECTION 5: Firefighting measures 5.1 Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. 5.2 Special hazards arising from the substance or mixture Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas 5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary. 5.4 Further information No data available

SECTION 6: Accidental release measures 6.1 Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. 6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. 6.3 Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal. 6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage 7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. 7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible solids, toxic 7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection 8.1 Control parameters 8.2 Exposure controls Appropriate engineering controls Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product. Personal protective equipment Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of Aldrich - D55407 Page 3 of 7

contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

SECTION 9: Physical and chemical properties 9.1 Information on basic physical and chemical properties a) Appearance Form: solid Colour: dark brown b) Odour No data available c) Odour Threshold No data available d) pH No data available e) Melting point/freezing Melting point/range: 20 - 25 °C point f) Initial boiling point and 252 °C boiling range g) Flash point 115 °C - closed cup h) Evaporation rate No data available i) Flammability (solid, gas) No data available j) Upper/lower No data available flammability or explosive limits k) Vapour pressure No data available l) Vapour density No data available m) Relative density 1.37 g/mL at 20 °C n) Water solubility No data available o) Partition coefficient: n- log Pow: 2.78 octanol/water p) Auto-ignition No data available temperature q) Decomposition No data available temperature r) Viscosity No data available s) Explosive properties No data available t) Oxidizing properties No data available

Aldrich - D55407 Page 4 of 7

9.2 Other safety information No data available

SECTION 10: Stability and reactivity 10.1 Reactivity No data available 10.2 Chemical stability Stable under recommended storage conditions. 10.3 Possibility of hazardous reactions No data available 10.4 Conditions to avoid No data available 10.5 Incompatible materials acids, Acid chlorides, Acid anhydrides, Oxidizing agents 10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information 11.1 Information on toxicological effects Acute toxicity LC50 Inhalation - Rat - 4 h - > 8,047 mg/m3(2,3-Dichloroaniline) Remarks: Behavioral:Somnolence (general depressed activity). Behavioral:Tremor. Nutritional and Gross Metabolic:Weight loss or decreased weight gain. Skin corrosion/irritation No data available(2,3-Dichloroaniline) Serious eye damage/eye irritation No data available(2,3-Dichloroaniline) Respiratory or skin sensitisation Germ cell mutagenicity

No data available(2,3-Dichloroaniline) Carcinogenicity IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity No data available(2,3-Dichloroaniline) Specific target organ toxicity - single exposure No data available(2,3-Dichloroaniline) Specific target organ toxicity - repeated exposure May cause damage to organs through prolonged or repeated exposure. Aspiration hazard No data available(2,3-Dichloroaniline)

Additional Information RTECS: Not available

Aldrich - D55407 Page 5 of 7

Absorption into the body leads to the formation of methemoglobin which in delayed 2 to 4 hours or longer., To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(2,3-Dichloroaniline)

SECTION 12: Ecological information 12.1 Toxicity No data available 12.2 Persistence and degradability Biodegradability Result: - Not readily biodegradable.

12.3 Bioaccumulative potential No data available 12.4 Mobility in soil No data available(2,3-Dichloroaniline) 12.5 Results of PBT and vPvB assessment PBT/vPvB assessment not available as chemical safety assessment not required/not conducted 12.6 Other adverse effects Very toxic to aquatic life with long lasting effects.

SECTION 14: Transport information 14.1 UN number ADR/RID: 3442 IMDG: 3442 IATA: 3442 14.2 UN proper shipping name ADR/RID: DICHLOROANILINES, SOLID IMDG: DICHLOROANILINES, SOLID IATA: Dichloroanilines, solid 14.3 Transport hazard class(es) ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1 14.4 Packaging group ADR/RID: II IMDG: II IATA: II 14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: yes IATA: no 14.6 Special precautions for user No data available

Aldrich - D55407 Page 6 of 7

SECTION 16: Other information Full text of H-Statements referred to under sections 2 and 3. H301 Toxic if swallowed. H311 Toxic in contact with skin. H331 Toxic if inhaled. H373 May cause damage to organs through prolonged or repeated exposure. H400 Very toxic to aquatic life. H410 Very toxic to aquatic life with long lasting effects. Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma- aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

Aldrich - D55407 Page 7 of 7

SAFETY DATA SHEET

Creation Date 22-Sep-2009 Revision Date 24-Jan-2018 Revision Number 4

1. Identification Product Name Nitrosylsulfuric acid (40% in sulfuric acid)

Cat No. : AC416210000; AC416215000

Synonyms Nitrosyl sulfate

Recommended Use Laboratory chemicals. Uses advised against Not for food, drug, pesticide or biocidal product use

Details of the supplier of the safety data sheet

Company Fisher Scientific Acros Organics One Reagent Lane One Reagent Lane Fair Lawn, NJ 07410 Fair Lawn, NJ 07410 Tel: (201) 796-7100

2. Hazard(s) identification Classification This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)

Corrosive to metals Category 1 Acute Inhalation Toxicity - Vapors Category 1 Skin Corrosion/irritation Category 1 A Serious Eye Damage/Eye Irritation Category 1 Carcinogenicity Category 1A

Label Elements

Signal Word Danger

Hazard Statements May intensify fire; oxidizer May be corrosive to metals Fatal if inhaled Causes severe skin burns and eye damage May cause cancer

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Precautionary Statements Prevention Obtain special instructions before use Do not handle until all safety precautions have been read and understood Wear protective gloves/protective clothing/eye protection/face protection In case of inadequate ventilation wear respiratory protection Use only outdoors or in a well-ventilated area Do not breathe dust/fume/gas/mist/vapors/spray Wash face, hands and any exposed skin thoroughly after handling Keep away from heat/sparks/open flames/hot surfaces. - No smoking Keep/Store away from clothing/ other combustible materials Take any precaution to avoid mixing with combustibles Keep only in original container Response IF exposed or concerned: Get medical attention/advice Inhalation IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing Immediately call a POISON CENTER or doctor/physician Skin IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower Wash contaminated clothing before reuse Immediately call a POISON CENTER or doctor/physician Eyes IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing Immediately call a POISON CENTER or doctor/physician Ingestion IF SWALLOWED: Rinse mouth. DO NOT induce vomiting Fire Explosion risk in case of fire In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion Evacuate area Storage Store locked up Store in a dry place. Store in a closed container Store in a well-ventilated place. Keep cool Store in corrosive resistant polypropylene container with a resistant inliner Disposal Dispose of contents/container to an approved waste disposal plant Hazards not otherwise classified (HNOC) Reacts violently with water Contact with water liberates toxic gas WARNING. Cancer - https://www.p65warnings.ca.gov/. Unknown Acute Toxicity 40 percent of the mixture consists of ingredient(s) of unknown acute toxicity

3. Composition/Information on Ingredients

Component CAS-No Weight % Sulfuric acid 7664-93-9 60 Nitrosylsulfuric acid 7782-78-7 40

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4. First-aid measures

Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Immediate medical attention is required.

Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Immediate medical attention is required.

Inhalation Move to fresh air. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Immediate medical attention is required. If not breathing, give artificial respiration.

Ingestion Do not induce vomiting. Call a physician or Poison Control Center immediately.

Most important symptoms and Causes burns by all exposure routes. Product is a corrosive material. Use of gastric effects lavage or emesis is contraindicated. Possible perforation of stomach or esophagus should be investigated: Ingestion causes severe swelling, severe damage to the delicate tissue and danger of perforation Notes to Physician Treat symptomatically

5. Fire-fighting measures Suitable Extinguishing Media Carbon dioxide (CO 2), Dry powder,

Unsuitable Extinguishing Media DO NOT USE WATER

Flash Point No information available Method - No information available

Autoignition Temperature No information available Explosion Limits Upper No data available Lower No data available Sensitivity to Mechanical Impact No information available Sensitivity to Static Discharge No information available

Specific Hazards Arising from the Chemical Contact with water liberates toxic gas. Water reactive. Thermal decomposition can lead to release of irritating gases and vapors. Keep product and empty container away from heat and sources of ignition.

Hazardous Combustion Products Nitrogen oxides (NOx) Sulfur oxides Protective Equipment and Precautions for Firefighters As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear.

NFPA Health Flammability Instability Physical hazards 4 3 2 OX W

6. Accidental release measures Personal Precautions Ensure adequate ventilation. Use personal protective equipment. Evacuate personnel to safe areas. Keep people away from and upwind of spill/leak. Remove all sources of ignition. Avoid contact with skin, eyes and clothing. Environmental Precautions See Section 12 for additional ecological information.

Methods for Containment and Clean Soak up with inert absorbent material (e.g. sand, silica gel, acid binder, universal binder, Up sawdust). Keep in suitable, closed containers for disposal. Keep container tightly closed in

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a dry and well-ventilated place.

7. Handling and storage Handling Use only under a chemical fume hood. Ensure adequate ventilation. Do not get in eyes, on skin, or on clothing. Avoid breathing dust/fume/gas/mist/vapors/spray. Protect from moisture. Keep away from clothing and other combustible materials.

Storage Corrosives area. Do not store near combustible materials. Keep refrigerated. Store under an inert atmosphere. Keep in a dry place. Keep container tightly closed. Keep containers tightly closed in a dry, cool and well-ventilated place.

8. Exposure controls / personal protection Exposure Guidelines

Component ACGIH TLV OSHA PEL NIOSH IDLH Mexico OEL (TWA) Sulfuric acid TWA: 0.2 mg/m3 (Vacated) TWA: 1 mg/m3 IDLH: 15 mg/m3 TWA: 1 mg/m3 TWA: 1 mg/m3 TWA: 1 mg/m3

Legend

ACGIH - American Conference of Governmental Industrial Hygienists OSHA - Occupational Safety and Health Administration NIOSH IDLH: The National Institute for Occupational Safety and Health Immediately Dangerous to Life or Health

Engineering Measures Ensure that eyewash stations and safety showers are close to the workstation location.

Personal Protective Equipment

Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.

Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure.

Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Hygiene Measures Handle in accordance with good industrial hygiene and safety practice.

9. Physical and chemical properties Physical State Viscous liquid Liquid Appearance Yellow Odor rotten-egg like Odor Threshold No information available pH <2 Melting Point/Range -10 °C / 14 °F Boiling Point/Range No information available Flash Point No information available Evaporation Rate No information available Flammability (solid,gas) Not applicable Flammability or explosive limits Upper No data available Lower No data available Vapor Pressure No information available Vapor Density 4.28 Specific Gravity 1.900 Solubility Reacts violently with water

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Partition coefficient; n-octanol/water No data available Autoignition Temperature No information available Decomposition Temperature No information available Viscosity No information available Molecular Formula H N O5 S Molecular Weight 127.08

10. Stability and reactivity

Reactive Hazard Yes

Stability Moisture sensitive. Reacts violently with water. Contact with water liberates toxic gas.

Conditions to Avoid Incompatible products. Exposure to moist air or water. Combustible material.

Incompatible Materials Bases, Water, Strong oxidizing agents, Reducing agents, Powdered metals

Hazardous Decomposition Products Nitrogen oxides (NOx), Sulfur oxides

Hazardous Polymerization Hazardous polymerization does not occur.

Hazardous Reactions None under normal processing.

11. Toxicological information Acute Toxicity

Product Information Oral LD50 Based on ATE data, the classification criteria are not met. ATE > 2000 mg/kg. Dermal LD50 Based on ATE data, the classification criteria are not met. ATE > 2000 mg/kg. Vapor LC50 Category 1. ATE < 0.5 mg/l. Component Information Component LD50 Oral LD50 Dermal LC50 Inhalation Sulfuric acid 2140 mg/kg ( Rat ) Not listed LC50 = 510 mg/m3 ( Rat ) 2 h

Toxicologically Synergistic No information available Products Delayed and immediate effects as well as chronic effects from short and long-term exposure

Irritation Causes burns by all exposure routes

Sensitization No information available

Carcinogenicity Possible cancer hazard. May cause cancer based on animal data. The table below indicates whether each agency has listed any ingredient as a carcinogen.

Component CAS-No IARC NTP ACGIH OSHA Mexico Sulfuric acid 7664-93-9 Group 1 Known A2 X A2 Nitrosylsulfuric acid 7782-78-7 Not listed Not listed Not listed Not listed Not listed Mutagenic Effects No information available

Reproductive Effects No information available.

Developmental Effects No information available.

Teratogenicity No information available.

STOT - single exposure None known STOT - repeated exposure None known

Aspiration hazard No information available

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Symptoms / effects,both acute and Product is a corrosive material. Use of gastric lavage or emesis is contraindicated. delayed Possible perforation of stomach or esophagus should be investigated: Ingestion causes severe swelling, severe damage to the delicate tissue and danger of perforation

Endocrine Disruptor Information No information available

Other Adverse Effects The toxicological properties have not been fully investigated.

12. Ecological information Ecotoxicity Do not empty into drains. Do not flush into surface water or sanitary sewer system.

Component Freshwater Algae Freshwater Fish Microtox Water Flea Sulfuric acid - LC50: > 500 mg/L, 96h static - EC50: 29 mg/L/24h (Brachydanio rerio)

Persistence and Degradability Soluble in water Persistence is unlikely based on information available.

Bioaccumulation/ Accumulation No information available.

Mobility Will likely be mobile in the environment due to its water solubility.

14. Transport information DOT UN-No UN3129 Proper Shipping Name WATER-REACTIVE LIQUID, CORROSIVE, N.O.S. Proper technical name Sulfuric acid ,Nitrosylsulfuric acid Hazard Class 4.3 Subsidiary Hazard Class 8 Packing Group II TDG UN-No UN3264 Proper Shipping Name CORROSIVE LIQUID, ACIDIC, INORGANIC, N.O.S. Hazard Class 8 Packing Group II IATA UN-No UN3264 Proper Shipping Name CORROSIVE LIQUID, ACIDIC, INORGANIC, N.O.S. Hazard Class 8 Packing Group II IMDG/IMO UN-No UN3264 Proper Shipping Name CORROSIVE LIQUID, ACIDIC, INORGANIC, N.O.S. Hazard Class 8 Packing Group II 15. Regulatory information

International Inventories

Component TSCA DSL NDSL EINECS ELINCS NLP PICCS ENCS AICS IECSC KECL Sulfuric acid X X - 231-639-5 - X X X X X Nitrosylsulfuric acid X X - 231-964-2 - X X X X X

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Legend: X - Listed E - Indicates a substance that is the subject of a Section 5(e) Consent order under TSCA. F - Indicates a substance that is the subject of a Section 5(f) Rule under TSCA. N - Indicates a polymeric substance containing no free-radical initiator in its inventory name but is considered to cover the designated polymer made with any free-radical initiator regardless of the amount used. P - Indicates a commenced PMN substance R - Indicates a substance that is the subject of a Section 6 risk management rule under TSCA. S - Indicates a substance that is identified in a proposed or final Significant New Use Rule T - Indicates a substance that is the subject of a Section 4 test rule under TSCA. XU - Indicates a substance exempt from reporting under the Inventory Update Rule, i.e. Partial Updating of the TSCA Inventory Data Base Production and Site Reports (40 CFR 710(B). Y1 - Indicates an exempt polymer that has a number-average molecular weight of 1,000 or greater. Y2 - Indicates an exempt polymer that is a polyester and is made only from reactants included in a specified list of low concern reactants that comprises one of the eligibility criteria for the exemption rule.

U.S. Federal Regulations

TSCA 12(b) Not applicable

SARA 313 Component CAS-No Weight % SARA 313 - Threshold Values % Sulfuric acid 7664-93-9 60 1.0

SARA 311/312 Hazard Categories See section 2 for more information

CWA (Clean Water Act) Component CWA - Hazardous CWA - Reportable CWA - Toxic Pollutants CWA - Priority Pollutants Substances Quantities Sulfuric acid X 1000 lb - -

Clean Air Act Not applicable

OSHA Occupational Safety and Health Administration Not applicable

CERCLA This material, as supplied, contains one or more substances regulated as a hazardous substance under the Comprehensive Environmental Response Compensation and Liability Act (CERCLA) (40 CFR 302)

Component Hazardous Substances RQs CERCLA EHS RQs Sulfuric acid 1000 lb 1000 lb California Proposition 65 This product contains the following proposition 65 chemicals

Component CAS-No California Prop. 65 Prop 65 NSRL Category Sulfuric acid 7664-93-9 Carcinogen - Carcinogen U.S. State Right-to-Know Regulations Component Massachusetts New Jersey Pennsylvania Illinois Rhode Island Sulfuric acid X X X X X Nitrosylsulfuric acid - X - - -

U.S. Department of Transportation

Reportable Quantity (RQ): N DOT Marine Pollutant N DOT Severe Marine Pollutant N

U.S. Department of Homeland Security This product does not contain any DHS chemicals.

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Other International Regulations

Mexico - Grade No information available

16. Other information Prepared By Regulatory Affairs Thermo Fisher Scientific Email: [email protected]

Creation Date 22-Sep-2009 Revision Date 24-Jan-2018 Print Date 24-Jan-2018 Revision Summary This document has been updated to comply with the US OSHA HazCom 2012 Standard replacing the current legislation under 29 CFR 1910.1200 to align with the Globally Harmonized System of Classification and Labeling of Chemicals (GHS).

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SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 30.03.2016 Print Date 15.12.2018 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1 Product identifiers Product name : 3,4-Dichloroaniline

Product Number : 437778 Brand : Aldrich Index-No. : 612-202-00-1 REACH No. : A registration number is not available for this substance as the substance or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline. CAS-No. : 95-76-1 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Manufacture of substances 1.3 Details of the supplier of the safety data sheet Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 Serious eye damage (Category 1), H318 Skin sensitisation (Category 1), H317 Acute aquatic toxicity (Category 1), H400 Chronic aquatic toxicity (Category 1), H410 Acute toxicity, Inhalation (Category 3), H331 Acute toxicity, Dermal (Category 3), H311 Acute toxicity, Oral (Category 3), H301 For the full text of the H-Statements mentioned in this Section, see Section 16. 2.2 Label elements Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger

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Hazard statement(s) H301 Toxic if swallowed. H311 Toxic in contact with skin. H317 May cause an allergic skin reaction. H318 Causes serious eye damage. H331 Toxic if inhaled. H410 Very toxic to aquatic life with long lasting effects.

Precautionary statement(s) P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P273 Avoid release to the environment. P280 Wear protective gloves/ eye protection/ face protection. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P311 Call a POISON CENTER /doctor.

SECTION 3: Composition/information on ingredients 3.1 Substances Formula : C6H5Cl2N Molecular weight : 162.02 g/mol CAS-No. : 95-76-1 EC-No. : 202-448-4 Index-No. : 612-202-00-1

Hazardous ingredients according to Regulation (EC) No 1272/2008 Component Classification Concentration 3,4-Dichloroaniline CAS-No. 95-76-1 Acute Tox. 3; Eye Dam. 1; <= 100 % EC-No. 202-448-4 Skin Sens. 1; Aquatic Acute 1; Index-No. 612-202-00-1 Aquatic Chronic 1; H331, H311, H301, H318, H317, H400, H410 M-Factor - Aquatic Acute: 10 For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures 4.1 Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

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4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures 5.1 Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. 5.2 Special hazards arising from the substance or mixture Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas 5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary. 5.4 Further information No data available

SECTION 7: Handling and storage 7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. 7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Light sensitive. Storage class (TRGS 510): Combustible solids, toxic 7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

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Personal protective equipment Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Full contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M)

Splash contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M)

h) Evaporation rate No data available i) Flammability (solid, gas) No data available j) Upper/lower Upper explosion limit: 7.2 %(V) flammability or Lower explosion limit: 2.8 %(V) explosive limits k) Vapour pressure No data available l) Vapour density 6.49 m) Relative density No data available n) Water solubility No data available o) Partition coefficient: n- No data available octanol/water p) Auto-ignition No data available temperature q) Decomposition No data available temperature r) Viscosity No data available s) Explosive properties No data available t) Oxidizing properties No data available 9.2 Other safety information Relative vapour density 6.49

SECTION 10: Stability and reactivity 10.1 Reactivity No data available 10.2 Chemical stability Stable under recommended storage conditions. 10.3 Possibility of hazardous reactions No data available 10.4 Conditions to avoid No data available 10.5 Incompatible materials Acid anhydrides, Oxidizing agents 10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information 11.1 Information on toxicological effects Acute toxicity LD50 Oral - Rat - 545 mg/kg(3,4-Dichloroaniline) Skin corrosion/irritation Skin - Rabbit(3,4-Dichloroaniline) Result: Severe skin irritation

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Serious eye damage/eye irritation Eyes - Rabbit(3,4-Dichloroaniline) Result: Severe eye irritation Respiratory or skin sensitisation Causes sensitisation.(3,4-Dichloroaniline) Germ cell mutagenicity

Human(3,4-Dichloroaniline) lymphocyte Sister chromatid exchange Carcinogenicity IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity No data available(3,4-Dichloroaniline) Specific target organ toxicity - single exposure No data available(3,4-Dichloroaniline) Specific target organ toxicity - repeated exposure No data available Aspiration hazard No data available(3,4-Dichloroaniline)

Additional Information RTECS: BX2625000

SECTION 12: Ecological information 12.1 Toxicity

Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 7 - 10 mg/l - 96.0 h(3,4- Dichloroaniline)

Toxicity to daphnia and EC50 - Daphnia magna (Water flea) - 0.05 - 2.20 mg/l - 48 h(3,4- other aquatic Dichloroaniline) invertebrates

Toxicity to algae EC50 - Pseudokirchneriella subcapitata (green algae) - 4.9 mg/l - 72 h(3,4- Dichloroaniline)

Growth inhibition LOEC - Algae - 1 - 10 mg/l - 28 d(3,4-Dichloroaniline) 12.2 Persistence and degradability Biodegradability Result: - Not readily biodegradable.

12.3 Bioaccumulative potential Bioaccumulation Poecilia reticulata (guppy) - 48 h - 48.6 µg/l(3,4-Dichloroaniline)

Bioconcentration factor (BCF): 96 12.4 Mobility in soil No data available(3,4-Dichloroaniline) 12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

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12.6 Other adverse effects Very toxic to aquatic life with long lasting effects.

SECTION 16: Other information Full text of H-Statements referred to under sections 2 and 3. H301 Toxic if swallowed. H311 Toxic in contact with skin. H317 May cause an allergic skin reaction. H318 Causes serious eye damage. H331 Toxic if inhaled. H400 Very toxic to aquatic life. H410 Very toxic to aquatic life with long lasting effects. Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma- aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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Version 6.2 SAFETY DATA SHEET Revision Date 13.12.2018 according to Regulation (EC) No. 1907/2006 Print Date 17.12.2018 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1 Product identifiers Product name : Glycerol

Product Number : G9012 Brand : Sigma-Aldrich REACH No. : A registration number is not available for this substance as the substance or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline. CAS-No. : 56-81-5 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Manufacture of substances 1.3 Details of the supplier of the safety data sheet Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification 2.1 Classification of the substance or mixture

Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008. 2.2 Label elements Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008. 2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

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The life science business of Merck operates as MilliporeSigma in the US and Canada

SECTION 3: Composition/information on ingredients 3.1 Substances Synonyms : 1,2,3-Propanetriol Glycerin

Formula : C3H8O3 Molecular weight : 92,09 g/mol CAS-No. : 56-81-5 EC-No. : 200-289-5

No components need to be disclosed according to the applicable regulations.

SECTION 4: First aid measures 4.1 Description of first aid measures If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. In case of skin contact Wash off with soap and plenty of water. In case of eye contact Flush eyes with water as a precaution. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. 4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures 5.1 Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. 5.2 Special hazards arising from the substance or mixture Carbon oxides 5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary. 5.4 Further information No data available

SECTION 6: Accidental release measures 6.1 Personal precautions, protective equipment and emergency procedures Avoid breathing vapours, mist or gas. For personal protection see section 8.

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The life science business of Merck operates as MilliporeSigma in the US and Canada

6.2 Environmental precautions No special environmental precautions required. 6.3 Methods and materials for containment and cleaning up Keep in suitable, closed containers for disposal. 6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage 7.1 Precautions for safe handling For precautions see section 2.2. 7.2 Conditions for safe storage, including any incompatibilities Keep container tightly closed in a dry and well-ventilated place. Store in cool place. hygroscopic 7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection 8.1 Control parameters Components with workplace control parameters 8.2 Exposure controls Appropriate engineering controls General industrial hygiene practice. Personal protective equipment Eye/face protection Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Full contact Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M)

Splash contact Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M)

data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374

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The life science business of Merck operates as MilliporeSigma in the US and Canada

If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.

Body Protection Impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Respiratory protection not required. For nuisance exposures use type OV/AG (US) or type ABEK (EU EN 14387) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Control of environmental exposure No special environmental precautions required.

SECTION 9: Physical and chemical properties 9.1 Information on basic physical and chemical properties a) Appearance Form: liquid Colour: colourless b) Odour odourless c) Odour Threshold No data available d) pH 5,5 - 8 e) Melting Melting point/range: 20 °C point/freezing point f) Initial boiling point 182 °C at 27 hPa and boiling range g) Flash point 160 °C - closed cup h) Evaporation rate No data available i) Flammability (solid, No data available gas) j) Upper/lower Upper explosion limit: 19 %(V) at 1013 hPa flammability or Lower explosion limit: 2,7 %(V) at 1013 hPa explosive limits k) Vapour pressure 0,0033 hPa at 50 °C l) Vapour density 3,18 - (Air = 1.0) m) Relative density 1,25 g/mL n) Water solubility soluble o) Partition coefficient: No data available n-octanol/water p) Auto-ignition No data available temperature

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The life science business of Merck operates as MilliporeSigma in the US and Canada

q) Decomposition No data available temperature r) Viscosity No data available s) Explosive properties No data available t) Oxidizing properties No data available 9.2 Other safety information Surface tension 63,4 mN/m at 20 °C

Relative vapour 3,18 - (Air = 1.0) density

SECTION 10: Stability and reactivity 10.1 Reactivity No data available 10.2 Chemical stability Stable under recommended storage conditions. 10.3 Possibility of hazardous reactions No data available 10.4 Conditions to avoid No data available 10.5 Incompatible materials Strong bases, Strong oxidizing agents 10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information 11.1 Information on toxicological effects Acute toxicity LD50 Oral - Rat - 12.600 mg/kg LD50 Dermal - Rabbit - > 10.000 mg/kg Skin corrosion/irritation No data available Serious eye damage/eye irritation No data available Respiratory or skin sensitisation No data available Germ cell mutagenicity No data available Carcinogenicity IARC: No component of this product present at levels greater than or equal to 0.1% is

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The life science business of Merck operates as MilliporeSigma in the US and Canada

identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity No data available Specific target organ toxicity - single exposure No data available Specific target organ toxicity - repeated exposure No data available Aspiration hazard No data available Additional Information RTECS: MA8050000

Prolonged or repeated exposure may cause:, Nausea, Headache, Vomiting, To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

Kidney - Irregularities - Based on Human Evidence

SECTION 12: Ecological information 12.1 Toxicity No data available 12.2 Persistence and degradability No data available 12.3 Bioaccumulative potential No data available 12.4 Mobility in soil No data available 12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. 12.6 Other adverse effects No data available

SECTION 13: Disposal considerations 13.1 Waste treatment methods Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contaminated packaging Dispose of as unused product.

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The life science business of Merck operates as MilliporeSigma in the US and Canada

SECTION 14: Transport information 14.1 UN number ADR/RID: - IMDG: - IATA: - 14.2 UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods 14.3 Transport hazard class(es) ADR/RID: - IMDG: - IATA: - 14.4 Packaging group ADR/RID: - IMDG: - IATA: - 14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no 14.6 Special precautions for user No data available

15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information Further information Copyright 2018 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

The branding on the header and/or footer of this document may temporarily not visually match the product purchased as we transition our branding. However, all of the information in the document regarding the product remains unchanged and matches the product ordered. For further information please contact [email protected].

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The life science business of Merck operates as MilliporeSigma in the US and Canada

He a lt h 3 0 Fire 0 3 1 Re a c t iv it y 2 Pe rs o n a l Pro t e c t io n J Material Safety Data Sheet Potassium hydroxide MSDS

Section 1: Chemical Product and Company Identification

Product Name: Potassium hydroxide Contact Information: Catalog Codes: SLP4096, SLP3085, SLP4900, SLP2071 Sciencelab.com, Inc. 14025 Smith Rd. CAS#: 1310-58-3 Houston, Texas 77396 RTECS: TT2100000 US Sales: 1-800-901-7247 International Sales: 1-281-441-4400 TSCA: TSCA 8(b) inventory: Potassium hydroxide Order Online: ScienceLab.com CI#: Not available. CHEMTREC (24HR Emergency Telephone), call: Synonym: 1-800-424-9300 Chemical Name: Potassium Hydroxide International CHEMTREC, call: 1-703-527-3887 Chemical Formula: KOH For non-emergency assistance, call: 1-281-441-4400

Section 2: Composition and Information on Ingredients

Composition:

Name CAS # % by Weight Potassium hydroxide 1310-58-3 100

Toxicological Data on Ingredients: Potassium hydroxide: ORAL (LD50): Acute: 273 mg/kg [Rat].

Section 3: Hazards Identification

Potential Acute Health Effects: Very hazardous in case of skin contact (corrosive, irritant), of eye contact (irritant, corrosive), of ingestion, of inhalation. The amount of tissue damage depends on length of contact. Eye contact can result in corneal damage or blindness. Skin contact can produce inflammation and blistering. Inhalation of dust will produce irritation to gastro-intestinal or respiratory tract, characterized by burning, sneezing and coughing. Severe over-exposure can produce lung damage, choking, unconsciousness or death. Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering. Potential Chronic Health Effects: CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance may be toxic to upper respiratory tract, skin, eyes. Repeated or prolonged exposure to the substance can produce target organs damage. Repeated exposure of the eyes to a low level of dust can produce eye irritation. Repeated skin exposure can produce local skin destruction, or dermatitis. Repeated inhalation of dust can produce varying degree of respiratory irritation or lung damage.

p. 1 Section 4: First Aid Measures

Eye Contact: Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention immediately. Skin Contact: In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Cover the irritated skin with an emollient. Cold water may be used.Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention immediately. Serious Skin Contact: Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medical attention. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention immediately. Serious Inhalation: Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. WARNING: It may be hazardous to the person providing aid to give mouth-to-mouth resuscitation when the inhaled material is toxic, infectious or corrosive. Seek immediate medical attention. Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: Non-flammable. Auto-Ignition Temperature: Not applicable. Flash Points: Not applicable. Flammable Limits: Not applicable. Products of Combustion: Not available. Fire Hazards in Presence of Various Substances: metals, acids Explosion Hazards in Presence of Various Substances: Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in presence of static discharge: Not available. Fire Fighting Media and Instructions: Not applicable. Special Remarks on Fire Hazards: Violent reaction or ignition under appropriate conditions with acids, alcohols, p-bis(1,3-dibromoethyl) benzene, cyclopentadiene, germanium, hyponitrous acid, maleic anhydride, nitroalkanes, 2-nitrophenol, potassium peroxodisulfate, sugars, 2,2,3,3-tetrafluoropropanol, thorium dicarbide. Molten ortho -nitrophenol reacts violently with potassium hydroxide. When potassium hydroxide and tetrachloroethane are heated, a spontaneously flammable gas, chloroacetylene, is formed. When phosphorus is boiled in a solution of potassium hydroxide, phosphine gas is evolved which is spontaneously flammable. 1,2-Dichloroethylene and Potassium hydroxide reaction produces chloroacetylene which is spontaneously flammable in air. Potassium Persulfate and a little Potassium hydroxide and water will ignite. When wet, attacks metals such as aluminum, tin, lead, and zinc, producing flammable hydrogen gas. Special Remarks on Explosion Hazards:

p. 2 Potentially explosive reaction with bromoform + crown ethers, chlorine dioxide, nitrobenzene, nitromethane, nitrogen trichloride, peroxidized tetrahydrofuran, 2,4,6-trinitrotoluene. Reaction with ammonium hexachloroplatiate(2-) + heat forms heat sensitive explosive product. Potassium hydroxide will cause explosive decomposition of maleic anhydride. Detonation will occur when potassiuim hydroxide is mixed with n-methyl-nitroso urea and methylene chloride. Nitrogen trichloride explodes on contact with potassium hydroxide.

Section 6: Accidental Release Measures

Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. If necessary: Neutralize the residue with a dilute solution of acetic acid. Large Spill: Corrosive solid. Stop leak if without risk. Do not get water inside container. Do not touch spilled material. Use water spray to reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Call for assistance on disposal. Neutralize the residue with a dilute solution of acetic acid. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities.

Section 7: Handling and Storage

Precautions: Keep container dry. Do not ingest. Do not breathe dust. Never add water to this product. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin and eyes. Keep away from incompatibles such as organic materials, metals, acids, moisture. Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 23°C (73.4°F).

Section 8: Exposure Controls/Personal Protection

Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal Protection: Splash goggles. Synthetic apron. Vapor and dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Vapor and dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure Limits: CEIL: 2 (mg/m3) from OSHA (PEL) [United States] CEIL: 2 (mg/m3) from ACGIH (TLV) [United States] Consult local authorities for acceptable exposure limits.

Section 9: Physical and Chemical Properties

Physical state and appearance: Solid. (Solid pellets.) Odor: Odorless. Taste: Not available. Molecular Weight: 56.11 g/mole

p. 3 Color: White. pH (1% soln/water): 13 [Basic.] Boiling Point: Decomposition temperature: 1384°C (2523.2°F) Melting Point: 380°C (716°F) Critical Temperature: Not available. Specific Gravity: 2.044 (Water = 1) Vapor Pressure: Not applicable. Vapor Density: Not available. Volatility: Not available. Odor Threshold: Not available. Water/Oil Dist. Coeff.: Not available. Ionicity (in Water): Not available. Dispersion Properties: See solubility in water. Solubility: Easily soluble in cold water, hot water. Insoluble in diethyl ether.

Section 10: Stability and Reactivity Data

Stability: The product is stable. Instability Temperature: Not available. Conditions of Instability: Incompatible materials, dust generation, exposure to moist air or water. Incompatibility with various substances: Highly reactive with acids. Reactive with organic materials, metals, moisture. Corrosivity: Extremely corrosive in presence of aluminum, brass, and zinc. Slightly corrosive in presence of copper, of stainless steel(304). Non-corrosive in presence of stainless steel(316). Special Remarks on Reactivity: Hygroscopic (absorbs moisture from air). When dissolved in water or alcohol or when the solution is treated with acid, much heat is generated. Reacts violently with acids, halogens, halogenated hydrocarbons, maleic anhydride, organic anhydrides, isocyanates, alkylene oxides, epichlorhydrin, aldehydes, alcohols, gylcols, phenols, cresols, caprolactum solution. Also incompatible with nitro compounds (nitrobenzene, nitromethane, nitrogen trichloride), organic materials, acid anhydrides, acid chlorides, magnesium, peroxidized tetrahydrofuran, chlorine dioxide, maleic dicarbide, sugars. When wet attacks metals such as aluminum, tin, lead, and zinc. Special Remarks on Corrosivity: When wet, attacks metals such as aluminum, tin, lead, and zinc, producing flammable hydrogen gas. Severe corrosive effect on brass and bronze. Polymerization: Will not occur.

Section 11: Toxicological Information

Routes of Entry: Absorbed through skin. Inhalation. Ingestion. Toxicity to Animals: Acute oral toxicity (LD50): 273 mg/kg [Rat]. Chronic Effects on Humans:

p. 4 MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. May cause damage to the following organs: upper respiratory tract, skin, eyes. Other Toxic Effects on Humans: Extremely hazardous in case of inhalation (lung corrosive). Very hazardous in case of skin contact (corrosive, irritant), of eye contact (corrosive), of ingestion, . Special Remarks on Toxicity to Animals: Not available. Special Remarks on Chronic Effects on Humans: May affect genetic material based on animal data. Special Remarks on other Toxic Effects on Humans: Acute Potential Health Effects: Skin: Causes severe skin irritation and burns. Eyes: Causes severe eye irritation and burns. May cause irreversible eye injury. Inhalation: Causes severe irritation and burns of the respiratory tract and mucous membranes. Irritation may lead to chemical pneumonitis Ingestion: Harmful if swallowed. May cause severe and permanent damage to the digestive tract. Causes severe irritation and burns of the gastrointestinal (digestive) tract with abdominal pain, vomiting and possible death. May cause perforation of the digestive tract. Chronic Potential Health Effects: Chronic contact with dilute solutions of potassium hydroxide can cause dermatitis. Inhalation can produce chronic productive cough, and shortness of breath.

Section 12: Ecological Information

Ecotoxicity: Ecotoxicity in water (LC50): 80 mg/l 24 hours [Mosquito Fish]. BOD5 and COD: Not available. Products of Biodegradation: Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself. Special Remarks on the Products of Biodegradation: Not available.

Section 13: Disposal Considerations

Waste Disposal: Waste must be disposed of in accordance with federal, state and local environmental control regulations.

Section 14: Transport Information

DOT Classification: Class 8: Corrosive material Identification: : Potassium hydroxide, solid UNNA: 1813 PG: II Special Provisions for Transport: Not available.

Section 15: Other Regulatory Information

Federal and State Regulations: New York release reporting list: Potassium hydroxide Pennsylvania RTK: Potassium hydroxide Florida: Potassium hydroxide Minnesota: Potassium hydroxide Massachusetts RTK: Potassium hydroxide New Jersey: Potassium hydroxide California Director's List of Hazardous Substances: Potassium hydroxide TSCA 8(b) inventory: Potassium hydroxide CERCLA: Hazardous substances.: Potassium hydroxide: 1000 lbs. (453.6 kg) Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.

p. 5 Other Classifications: WHMIS (Canada): CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC). CLASS E: Corrosive solid. DSCL (EEC): HMIS (U.S.A.): Health Hazard: 3 Fire Hazard: 0 Reactivity: 2 Personal Protection: j National Fire Protection Association (U.S.A.): Health: 3 Flammability: 0 Reactivity: 1 Specific hazard: Protective Equipment: Gloves. Synthetic apron. Vapor and dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate. Splash goggles.

Section 16: Other Information

References: Not available. Other Special Considerations: Not available. Created: 10/10/2005 08:23 PM Last Updated: 05/21/2013 12:00 PM

p. 6 He a lt h 3 0 Fire 0 3 2 Re a c t iv it y 1 Pe rs o n a l Pro t e c t io n J Material Safety Data Sheet Phosphorus pentachloride MSDS

Section 1: Chemical Product and Company Identification

Product Name: Phosphorus pentachloride Contact Information: Catalog Codes: SLP4498 Sciencelab.com, Inc. 14025 Smith Rd. CAS#: 10026-13-8 Houston, Texas 77396 RTECS: TB6125000 US Sales: 1-800-901-7247 International Sales: 1-281-441-4400 TSCA: TSCA 8(b) inventory: Phosphorus pentachloride Order Online: ScienceLab.com CI#: Not available. CHEMTREC (24HR Emergency Telephone), call: Synonym: Phosphorane, Pentachloro-; Phosphoric 1-800-424-9300 Chloride; Phosphorus Perchloride International CHEMTREC, call: 1-703-527-3887 Chemical Name: Phosphorus Pentachloride For non-emergency assistance, call: 1-281-441-4400 Chemical Formula: PCl5

Section 2: Composition and Information on Ingredients

Composition:

Name CAS # % by Weight Phosphorus pentachloride 10026-13-8 100

Toxicological Data on Ingredients: Phosphorus pentachloride: ORAL (LD50): Acute: 660 mg/kg [Rat].

Section 3: Hazards Identification

Potential Acute Health Effects: Very hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Hazardous in case of skin contact (corrosive), of eye contact (corrosive). The amount of tissue damage depends on length of contact. Eye contact can result in corneal damage or blindness. Skin contact can produce inflammation and blistering. Inhalation of dust will produce irritation to gastro-intestinal or respiratory tract, characterized by burning, sneezing and coughing. Severe over-exposure can produce lung damage, choking, unconsciousness or death. Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering. Potential Chronic Health Effects: CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance is toxic to mucous membranes. The substance may be toxic to kidneys, liver. Repeated or prolonged exposure to the substance can produce target organs damage. Repeated exposure of the eyes to a low level of dust can produce eye irritation. Repeated skin exposure can produce local skin destruction, or dermatitis. Repeated inhalation of dust can produce varying degree of respiratory irritation or lung damage. Repeated

p. 1 exposure to a highly toxic material may produce general deterioration of health by an accumulation in one or many human organs.

Section 4: First Aid Measures

Section 5: Fire and Explosion Data

Section 6: Accidental Release Measures

Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container.

p. 2 Large Spill: Corrosive solid. Poisonous solid. Stop leak if without risk. Do not get water inside container. Do not touch spilled material. Use water spray to reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Call for assistance on disposal. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities.

Section 7: Handling and Storage

Precautions: Keep locked up.. Keep container dry. Keep away from heat. Keep away from sources of ignition. Keep away from direct sunlight or strong incandescent light. Do not ingest. Do not breathe dust. Never add water to this product. Avoid shock and friction. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin and eyes. Keep away from incompatibles such as oxidizing agents, metals, moisture. Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area.

Section 8: Exposure Controls/Personal Protection

Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal Protection: Splash goggles. Synthetic apron. Vapor and dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Vapor and dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure Limits: TWA: 1 (mg/m3) from OSHA (PEL) [United States] TWA: 0.1 (ppm) from ACGIH (TLV) [United States] TWA: 1 (mg/m3) from NIOSH [United States] TWA: 0.1 (ppm) [United Kingdom (UK)] TWA: 0.87 (mg/m3) [United Kingdom (UK)]3 Consult local authorities for acceptable exposure limits.

Section 9: Physical and Chemical Properties

Physical state and appearance: Solid. (Deliquescent solid. Crystalline solid.) Odor: Unpleasant. Pungent. Taste: Not available. Molecular Weight: 208.24 g/mole Color: White to light yellow. pH (1% soln/water): Not available. Boiling Point: 159°C (318.2°F) - 160 C (sublimes) Melting Point: Sublimation temperature: 160°C (320°F) - 165 C (Sax & Lewis, 1987) Sublimation temperature: 167 C (Sittig, 1985) Sublimation temperature: 100 C (Budavari, 1989) Sublimes at about 100 C without melting (Merck Index, 13th ed., 2001) Melting point: 148 C (under pressure) (Merck Index, 13th ed., 2001) (Budavari, 1989) Critical Temperature: 372°C (701.6°F)

p. 3 Specific Gravity: Density: 2.114 - 3.60(Water = 1) Vapor Pressure: Not applicable. Vapor Density: Not available. Volatility: Not available. Odor Threshold: Not available. Water/Oil Dist. Coeff.: Not available. Ionicity (in Water): Not available. Dispersion Properties: Not available. Solubility: Decomposes in cold water, and in acid. Soluble in Carbon Disulfide, and Carbon Tetrachloride

Section 10: Stability and Reactivity Data

Stability: The product is stable. Instability Temperature: Not available. Conditions of Instability: Incompatible materials, moisture, water Incompatibility with various substances: Reactive with oxidizing agents, metals, acids, alkalis, moisture. Corrosivity: Non-corrosive in presence of glass. Special Remarks on Reactivity: Reacts with alcohols to form the corresponding chloride. Fuming in moist air. It will react with water or steam to produce heat as well as toxic and corrosive fumes. It is hydrolyzed by water to form phosphoric acid, and hydrogen chloride. Reacts violently with water, ClO3, Hydroxylamine, Magnesium oxide, Nitrobenzene, Phosphorus (III) oxide, Potassium. It is also incompatible with the following: Aluminum, Chlorine dioxide, Chlorine, Diphosphorus trioxide, Fluorine, Magnesium oxide, sodium, 3'- Methyl-2-nitrobenzanilide, Special Remarks on Corrosivity: Not available. Polymerization: Will not occur.

Section 11: Toxicological Information

Routes of Entry: Inhalation. Ingestion. Toxicity to Animals: WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oral toxicity (LD50): 660 mg/kg [Rat]. Acute toxicity of the vapor (LC50): 205 8 hours [Rat]. Chronic Effects on Humans: Causes damage to the following organs: mucous membranes. May cause damage to the following organs: kidneys, liver. Other Toxic Effects on Humans: Very hazardous in case of skin contact (irritant), of ingestion, . Hazardous in case of skin contact (corrosive), of eye contact (corrosive), of inhalation (lung corrosive). Special Remarks on Toxicity to Animals: Not available. Special Remarks on Chronic Effects on Humans: Not available. Special Remarks on other Toxic Effects on Humans: Acute Potential Health Effects: Skin: Causes severe skin irritation and burns. Eyes: Causes severe irritation and burns of the eyes. Inhalation: Toxic if inhaled. Causes severe respiratory tract irritation and burns. Phosphorus chlorides are extremely

p. 4 destructive to the tissues (mucous membranes) of the respiratory tract. Inhalation may result in burning sensations, coughing, wheezing, shortness of breath, spasm, inflammation and edema of the larynx, and bronchi, chemical pneumonitis, and pulmonary edema. It may also affect behavior/central nervous system (somnolence, dizziness, headache, muscle contraction or spasticity, muscle weakness). Ingestion: Harmful if swallowed. Causes severe irritation and burns, nausea, and vomiting. Ingestion will lead to a strong corrosive efect on the mouth and throat and to the danger of perforation of the esophagus and stomach. It may also affect behavior/central nervous system with symptoms similar to that of inhalation. Chronic Potential Health Effects: Prolonged or repeated exposure by inhalation and ingestion may cause liver and kidney damage.

Section 12: Ecological Information

Section 13: Disposal Considerations

Waste Disposal: Waste must be disposed of in accordance with federal, state and local environmental control regulations.

Section 14: Transport Information

DOT Classification: Class 8: Corrosive material Identification: : Phosphorous pentachloride UNNA: 1806 PG: II Special Provisions for Transport: Not available.

Section 15: Other Regulatory Information

Federal and State Regulations: Connecticut hazardous material survey.: Phosphorus pentachloride Illinois toxic substances disclosure to employee act: Phosphorus pentachloride Illinois chemical safety act: Phosphorus pentachloride New York release reporting list: Phosphorus pentachloride Rhode Island RTK hazardous substances: Phosphorus pentachloride Pennsylvania RTK: Phosphorus pentachloride Minnesota: Phosphorus pentachloride Massachusetts RTK: Phosphorus pentachloride Massachusetts spill list: Phosphorus pentachloride New Jersey: Phosphorus pentachloride New Jersey spill list: Phosphorus pentachloride Louisiana RTK reporting list: Phosphorus pentachloride California Director's list of Hazardous Substances: Phosphorus pentachloride TSCA 8(b) inventory: Phosphorus pentachloride SARA 302/304/311/312 extremely hazardous substances: Phosphorus pentachloride CERCLA: Hazardous substances.: Phosphorus pentachloride Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances. Other Classifications: WHMIS (Canada): CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC). CLASS E: Corrosive solid. CLASS F: Dangerously reactive material. DSCL (EEC):

p. 5 R14- Reacts violently with water. R22- Harmful if swallowed. R26- Very toxic by inhalation. R34- Causes burns. S7/8- Keep container tightly closed and dry. S26- In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39- Wear suitable protective clothing, gloves and eye/face protection. S45- In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). HMIS (U.S.A.): Health Hazard: 3 Fire Hazard: 0 Reactivity: 1 Personal Protection: j National Fire Protection Association (U.S.A.): Health: 3 Flammability: 0 Reactivity: 2 Specific hazard: Protective Equipment: Gloves. Synthetic apron. Vapor and dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate. Splash goggles.

Section 16: Other Information

References: Not available. Other Special Considerations: Not available. Created: 10/11/2005 01:44 PM Last Updated: 05/21/2013 12:00 PM

p. 6 SAFETY DATA SHEET

1. Identification Product identifier Monoglycerides Other means of identification Catalog number 1446000 Chemical name Glycerides, C14-22 mono- Recommended use Specified quality tests and assay use only. Recommended restrictions Not for use as a drug. Not for administration to humans or animals. Manufacturer/Importer/Supplier/Distributor information Company name U. S. Pharmacopeia Address 12601 Twinbrook Parkway Rockville MD 20852-1790 US Telephone RS Technical Services 301-816-8129 Website www.usp.org E-mail [email protected] Emergency phone number CHEMTREC within US & 1-800-424-9300 Canada CHEMTREC outside US & +1 703-527-3887 Canada 2. Hazard(s) identification Physical hazards Not classified. Health hazards Not classified. OSHA hazard(s) Not classified. Label elements Hazard symbol No symbol. Signal word Not available. Hazard statement Not available. Precautionary statement Prevention Not available. Response Not available. Storage Not available. Disposal Not available. Hazard(s) not otherwise Not classified. classified (HNOC)

3. Composition/information on ingredients Substance Non-hazardous components Chemical name Common name and synonyms CAS number % Monoglycerides 68990-53-4 100

4. First-aid measures Inhalation If breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing. Call a physician if symptoms develop or persist. Skin contact Rinse skin with water/shower. Get medical attention if irritation develops and persists. Eye contact Rinse with water. Get medical attention if irritation develops and persists. Ingestion Rinse mouth. If ingestion of a large amount does occur, call a poison control center immediately.

Material name: Monoglycerides USP SDS US 5918 Version #: 02 Revision date: 09-20-2013 Issue date: 02-16-2005 1 / 5 Most important Not available. symptoms/effects, acute and delayed Indication of immediate Provide general supportive measures and treat symptomatically. medical attention and special treatment needed General information Remove from exposure. Remove contaminated clothing. For treatment advice, seek guidance from an occupational health physician or other licensed health-care provider familiar with workplace chemical exposures. In the United States, the national poison control center phone number is 1-800-222-1222. If person is not breathing, give artificial respiration. If breathing is difficult, give oxygen if available. Persons developing serious hypersensitivity (anaphylactic) reactions must receive immediate medical attention. 5. Fire-fighting measures Suitable extinguishing media Water spray, dry chemical, carbon dioxide, or foam as appropriate for surrounding fire and materials. Unsuitable extinguishing None known. media Specific hazards arising from No unusual fire or explosion hazards noted. the chemical Special protective equipment Wear suitable protective equipment. and precautions for firefighters Fire-fighting As with all fires, evacuate personnel to a safe area. Firefighters should use self-contained equipment/instructions breathing equipment and protective clothing. Specific methods Cool containers exposed to flames with water until well after the fire is out. 6. Accidental release measures Personal precautions, Keep unnecessary personnel away. Do not touch damaged containers or spilled material unless protective equipment and wearing appropriate protective clothing. Ensure adequate ventilation. Avoid inhalation of dust from emergency procedures the spilled material. Wear appropriate personal protective equipment. Methods and materials for Sweep up or vacuum up spillage and collect in suitable container for disposal. Avoid the containment and cleaning up generation of dusts during clean-up. For waste disposal, see section 13 of the SDS. Wash spill site. 7. Handling and storage Precautions for safe handling As a general rule, when handling USP Reference Standards, avoid all contact and inhalation of dust, mists, and/or vapors associated with the material. Clean equipment and work surfaces with suitable detergent or solvent after use. After removing gloves, wash hands and other exposed skin thoroughly. Conditions for safe storage, Store in tight container as defined in the USP-NF. This material should be handled and stored per including any incompatibilities label instructions to ensure product integrity. 8. Exposure controls/personal protection Biological limit values No biological exposure limits noted for the ingredient(s). Exposure guidelines No exposure standards allocated. Appropriate engineering Airborne exposure should be controlled primarily by engineering controls such as general dilution controls ventilation, local exhaust ventilation, or process enclosure. Local exhaust ventilation is generally preferred to general exhaust because it can control the contaminant at its source, preventing dispersion into the work area. An industrial hygiene survey involving air monitoring may be used to determine the effectiveness of engineering controls. Effectiveness of engineering controls intended for use with highly potent materials should be assessed by use of nontoxic surrogate materials. Individual protection measures, such as personal protective equipment Eye/face protection Safety glasses with sideshields are recommended. Face shields or goggles may be required if splash potential exists or if corrosive materials are present. Approved eye protection (e.g., bearing the ANSI Z87 or CSA stamp) is preferred. Maintain eyewash facilities in the work area. Skin protection Hand protection Chemically compatible gloves. For handling solutions, ensure that the glove material is protective against the solvent being used. Use handling practices that minimize direct hand contact. Employees who are sensitive to natural rubber (latex) should use nitrile or other synthetic nonlatex gloves. Use of powdered latex gloves should be avoided due to the risk of latex allergy. Other For handling of laboratory scale quantities, a cloth lab coat is recommended. Where significant quantities are handled, work clothing may be necessary to prevent take-home contamination. Respiratory protection Where respirators are deemed necessary to reduce or control occupational exposures, use NIOSH-approved respiratory protection and have an effective respirator program in place (applicable U.S. regulation OSHA 29 CFR 1910.134).

Material name: Monoglycerides USP SDS US 5918 Version #: 02 Revision date: 09-20-2013 Issue date: 02-16-2005 2 / 5 Thermal hazards Not available. General hygiene Handle in accordance with good industrial hygiene and safety practice. considerations 9. Physical and chemical properties Appearance White, wax-like beads. Physical state Solid. Form Powder. Odor Slight fatty odor. Odor threshold Not available. pH Not available. Melting point/freezing point 158 °F (70 °C) Initial boiling point and boiling Not available. range Flash point 496.40 °F (258.00 °C) Cleveland Open Cup Evaporation rate Not available. Flammability (solid, gas) Not applicable. Upper/lower flammability or explosive limits Flammability limit - lower Not available. (%) Flammability limit - upper Not available. (%) Explosive limit - lower (%) Not available. Explosive limit - upper (%) Not available. Vapor pressure < 0.0000001 kPa at 25 °C Vapor density Not available. Relative density Not available. Solubility in water Insoluble. Partition coefficient Not available. (n-octanol/water) Auto-ignition temperature 719.6 °F (382 °C) Decomposition temperature Not available. Viscosity Not available. Other information Chemical family Distilled monoglyceride. Solubility (other) Soluble in chloroform and in ether; slightly soluble in carbon disulfide. Specific gravity 0.92 @ 80 °C 10. Stability and reactivity Reactivity No reactivity hazards known. Chemical stability Material is stable under normal conditions. Possibility of hazardous No dangerous reaction known under conditions of normal use. reactions Conditions to avoid None known. Incompatible materials Strong oxidizing agents. Hazardous decomposition Irritating and/or toxic fumes or gases. Emits toxic fumes under fire conditions. products 11. Toxicological information Information on likely routes of exposure Ingestion Based on available data, the classification criteria are not met. Inhalation Due to lack of data the classification is not possible. Skin contact Due to lack of data the classification is not possible. Eye contact Due to lack of data the classification is not possible. Symptoms related to the Not available. physical, chemical, and toxicological characteristics

Material name: Monoglycerides USP SDS US 5918 Version #: 02 Revision date: 09-20-2013 Issue date: 02-16-2005 3 / 5 Acute toxicity Based on available data, the classification criteria are not met. Product Species Test Results Monoglycerides (CAS 68990-53-4) Oral LD50 Rat > 5000 mg/kg Skin corrosion/irritation Due to lack of data the classification is not possible. Serious eye damage/eye Due to lack of data the classification is not possible. irritation Respiratory sensitization Due to lack of data the classification is not possible. Skin sensitization Due to lack of data the classification is not possible. Germ cell mutagenicity Due to lack of data the classification is not possible. Carcinogenicity Due to lack of data the classification is not possible. This product is not considered to be a carcinogen by IARC, ACGIH, NTP, or OSHA. Reproductive toxicity Due to lack of data the classification is not possible. Specific target organ toxicity - Due to lack of data the classification is not possible. single exposure Specific target organ toxicity - Due to lack of data the classification is not possible. repeated exposure Aspiration hazard Based on available data, the classification criteria are not met. 12. Ecological information Ecotoxicity No ecotoxicity data noted for the ingredient(s). Persistence and degradability No data is available on the degradability of this product. Bioaccumulative potential Not available. Mobility in soil Not available. Other adverse effects Not available. 13. Disposal considerations Disposal instructions This product, in its present state, when discarded or disposed of, is not a hazardous waste according to Federal regulations (40 CFR 261.4 (b)(4)). Under RCRA, it is the responsibility of the user of the product to determine, at the time of disposal, whether the product meets RCRA criteria for hazardous waste. Dispose in accordance with all applicable regulations. Local disposal regulations Not available. Hazardous waste code Not regulated. Waste from residues / unused Empty containers or liners may retain some product residues. This material and its container must products be disposed of in a safe manner (see: Disposal instructions). Contaminated packaging Empty containers should be taken to an approved waste handling site for recycling or disposal. Since emptied containers may retain product residue, follow label warnings even after container is emptied. 14. Transport information DOT Not regulated as a hazardous material by DOT. IATA Not regulated as a dangerous good. Transport in bulk according to No information available. Annex II of MARPOL 73/78 and the IBC Code 15. Regulatory information US federal regulations CERCLA/SARA Hazardous Substances - Not applicable.

All components are on the U.S. EPA TSCA Inventory List. Superfund Amendments and Reauthorization Act of 1986 (SARA) Hazard categories Immediate Hazard - No Delayed Hazard - No Fire Hazard - No Pressure Hazard - No Reactivity Hazard - No

Material name: Monoglycerides USP SDS US 5918 Version #: 02 Revision date: 09-20-2013 Issue date: 02-16-2005 4 / 5 SARA 302 Extremely No hazardous substance SARA 311/312 Hazardous No chemical Other federal regulations Safe Drinking Water Act Not regulated. (SDWA) Food and Drug Not regulated. Administration (FDA) US state regulations California Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65): This material is not known to contain any chemicals currently listed as carcinogens or reproductive toxins. International Inventories Country(s) or region Inventory name On inventory (yes/no)* Australia Australian Inventory of Chemical Substances (AICS) Yes Canada Domestic Substances List (DSL) Yes Canada Non-Domestic Substances List (NDSL) No China Inventory of Existing Chemical Substances in China (IECSC) Yes Europe European Inventory of Existing Commercial Chemical Yes Substances (EINECS) Europe European List of Notified Chemical Substances (ELINCS) No Japan Inventory of Existing and New Chemical Substances (ENCS) No Korea Existing Chemicals List (ECL) Yes New Zealand New Zealand Inventory Yes Philippines Philippine Inventory of Chemicals and Chemical Substances Yes (PICCS) United States & Puerto Rico Toxic Substances Control Act (TSCA) Inventory Yes *A "Yes" indicates that all components of this product comply with the inventory requirements administered by the governing country(s) 16. Other information, including date of preparation or last revision Issue date 02-16-2005 Revision date 09-20-2013 Version # 02 Further information Not available. Disclaimer USP Reference Standards are sold for chemical test and assay purposes only, and NOT for human consumption. The information contained herein is applicable solely to the chemical substance when used as a USP Reference Standard and does not necessarily relate to any other use of the substance described, (i.e. at different concentrations, in drug dosage forms, or in bulk quantities). USP Reference Standards are intended for use by persons having technical skill and at their own discretion and risk. This information has been developed by USP staff from sources considered reliable but has not been independently verified by the USP. Therefore, the USP Convention cannot guarantee the accuracy of the information in these sources nor should the statements contained herein be considered an official expression. NO REPRESENTATION OR WARRANTY, EXPRESS OR IMPLIED, INCLUDING THE WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE is made with respect to the information contained herein. Revision Information This document has undergone significant changes and should be reviewed in its entirety.

Material name: Monoglycerides USP SDS US 5918 Version #: 02 Revision date: 09-20-2013 Issue date: 02-16-2005 5 / 5 He a lt h 3 2 Fire 2 3 1 Re a c t iv it y 0 Pe rs o n a l Pro t e c t io n Material Safety Data Sheet Acetic anhydride MSDS

Section 1: Chemical Product and Company Identification

Section 2: Composition and Information on Ingredients

Composition:

Name CAS # % by Weight Acetic anhydride 108-24-7 100

Toxicological Data on Ingredients: Acetic anhydride: ORAL (LD50): Acute: 1780 mg/kg [Rat]. DERMAL (LD50): Acute: 4000 mg/kg [Rabbit].

Section 3: Hazards Identification

p. 1 Section 4: First Aid Measures

Section 5: Fire and Explosion Data

Section 6: Accidental Release Measures

Small Spill: Absorb with an inert material and put the spilled material in an appropriate waste disposal.

Section 7: Handling and Storage

Section 8: Exposure Controls/Personal Protection

Section 9: Physical and Chemical Properties

p. 3 Volatility: Not available. Odor Threshold: 0.1 ppm Water/Oil Dist. Coeff.: Not available. Ionicity (in Water): Not available. Dispersion Properties: Not available. Solubility: Not available.

Section 10: Stability and Reactivity Data

Section 11: Toxicological Information

Section 12: Ecological Information

p. 4 Section 13: Disposal Considerations

Waste Disposal:

Section 14: Transport Information

DOT Classification: Class 8: Corrosive material Identification: : Acetic Anhydride UNNA: UN1715 PG: II Special Provisions for Transport: Not available.

Section 15: Other Regulatory Information

Section 16: Other Information

p. 6 He a lt h 2 1 Fire 1 2 0 Re a c t iv it y 0 Pe rs o n a l Pro t e c t io n E Material Safety Data Sheet Sodium acetate anhydrous MSDS

Section 1: Chemical Product and Company Identification

Product Name: Sodium acetate anhydrous Contact Information: Catalog Codes: SLS2710, SLS1918, SLS1123 Sciencelab.com, Inc. 14025 Smith Rd. CAS#: 127-09-3 Houston, Texas 77396 RTECS: AJ4300010 US Sales: 1-800-901-7247 International Sales: 1-281-441-4400 TSCA: TSCA 8(b) inventory: Sodium acetate anhydrous Order Online: ScienceLab.com CI#: Not applicable. CHEMTREC (24HR Emergency Telephone), call: Synonym: Acetic acid, sodium salt 1-800-424-9300 Chemical Name: Sodium acetate International CHEMTREC, call: 1-703-527-3887 Chemical Formula: CH3COONa For non-emergency assistance, call: 1-281-441-4400

Section 2: Composition and Information on Ingredients

Composition:

Name CAS # % by Weight Sodium acetate anhydrous 127-09-3 100

Toxicological Data on Ingredients: Not applicable.

Section 3: Hazards Identification

Potential Acute Health Effects: Hazardous in case of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant), of eye contact (irritant). Potential Chronic Health Effects: CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. Repeated or prolonged exposure is not known to aggravate medical condition.

Section 4: First Aid Measures

p. 1 Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold water may be used. Serious Skin Contact: Not available. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention if symptoms appear. Serious Inhalation: Not available. Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear. Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: May be combustible at high temperature. Auto-Ignition Temperature: Not available. Flash Points: Not available. Flammable Limits: Not available. Products of Combustion: These products are carbon oxides (CO, CO2). Fire Hazards in Presence of Various Substances: Slightly flammable to flammable in presence of open flames and sparks, of heat. Non-flammable in presence of shocks. Explosion Hazards in Presence of Various Substances: Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in presence of static discharge: Not available. Fire Fighting Media and Instructions: SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet. Special Remarks on Fire Hazards: Combustible when exposed to heat or flame. Special Remarks on Explosion Hazards: Not available.

Section 6: Accidental Release Measures

Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. If necessary: Neutralize the residue with a dilute solution of acetic acid. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Large Spill: Use a shovel to put the material into a convenient waste disposal container. Neutralize the residue with a dilute solution of acetic acid. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system.

Section 7: Handling and Storage

Precautions: Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust. Wear suitable protective clothing. In

p. 2 case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Keep away from incompatibles such as oxidizing agents, acids. Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area.

Section 8: Exposure Controls/Personal Protection

Section 9: Physical and Chemical Properties

Physical state and appearance: Solid. (Granular, crystalline powder.) Odor: Odorless to acetic (Slight.) Taste: Not available. Molecular Weight: 82.03 g/mole Color: Colorless. White. pH (1% soln/water): 11 [Basic.] Boiling Point: Not available. Melting Point: 324°C (615.2°F) Critical Temperature: Not available. Specific Gravity: 1.528 (Water = 1) Vapor Pressure: Not applicable. Vapor Density: Not available. Volatility: Not available. Odor Threshold: Not available. Water/Oil Dist. Coeff.: Not available. Ionicity (in Water): Not available. Dispersion Properties: See solubility in water. Solubility: Easily soluble in cold water, hot water.

Section 10: Stability and Reactivity Data

Stability: The product is stable.

p. 3 Instability Temperature: Not available. Conditions of Instability: Excess heat, incompatible materials, moisture. Incompatibility with various substances: Reactive with oxidizing agents, acids. Corrosivity: Non-corrosive in presence of glass. Special Remarks on Reactivity: Hygroscopic; keep container tightly closed. Incompatible (violent reaction) with fluorine diketene, potassium nitrate. Also incompatible wth nitric acid. Emits fumes of acetic acid upon heating and on contact with strong acids. Special Remarks on Corrosivity: Not available. Polymerization: Will not occur.

Section 11: Toxicological Information

Routes of Entry: Inhalation. Ingestion. Toxicity to Animals: WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oral toxicity (LD50): 3530 mg/kg [Rat]. Acute dermal toxicity (LD50): >10000 mg/kg [Rabbit]. Acute toxicity of the dust (LC50): >30000 mg/m 1 hours [Rat]. 3 Chronic Effects on Humans: Not available. Other Toxic Effects on Humans: Hazardous in case of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant). Special Remarks on Toxicity to Animals: Not available. Special Remarks on Chronic Effects on Humans: Not available. Special Remarks on other Toxic Effects on Humans: Acute Potential Health Effects: Skin: May cause skin irritation. Eyes: May cause eye irritation. Ingestion: May cause digestive tract irritation with abdominal pain, nausea, and vomiting. May affect behavior, and urinary system. Inhalation: May cause respiratory tract irritation. Symptoms may include coughing, sore throat, labored breathing, and chest pain.

Section 12: Ecological Information

Ecotoxicity: Not available. BOD5 and COD: Not available. Products of Biodegradation: Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic. Special Remarks on the Products of Biodegradation: Not available.

Section 13: Disposal Considerations

Waste Disposal: Waste must be disposed of in accordance with federal, state and local environmental control regulations.

Section 14: Transport Information

DOT Classification: Not a DOT controlled material (United States).

p. 4 Identification: Not applicable. Special Provisions for Transport: Not applicable.

Section 15: Other Regulatory Information

Federal and State Regulations: TSCA 8(b) inventory: Sodium acetate anhydrous Other Regulations: EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances. Other Classifications: WHMIS (Canada): Not controlled under WHMIS (Canada). DSCL (EEC): This product is not classified according to the EU regulations. Not applicable. HMIS (U.S.A.): Health Hazard: 2 Fire Hazard: 1 Reactivity: 0 Personal Protection: E National Fire Protection Association (U.S.A.): Health: 2 Flammability: 1 Reactivity: 0 Specific hazard: Protective Equipment: Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Safety glasses.

Section 16: Other Information

References: -Hawley, G.G.. The Condensed Chemical Dictionary, 11e ed., New York N.Y., Van Nostrand Reinold, 1987. -SAX, N.I. Dangerous Properties of Indutrial Materials. Toronto, Van Nostrand Reinold, 6e ed. 1984. -The Sigma-Aldrich Library of Chemical Safety Data, Edition II. Registery of Toxic Effects of Chemical Substances. Hazardous Substance Data Bank. Other Special Considerations: Not available. Created: 10/09/2005 06:28 PM Last Updated: 05/21/2013 12:00 PM

p. 5 Material Safety Data Sheet MSDS Number: M1004 Ethanol, Absolute Effective Date: 8/23/2004 Section 1 - Chemical Product and Company Identification

MSDS Name: Ethanol, Absolute Synonyms: Ethyl Alcohol; Ethyl Alcohol Anhydrous; Ethyl Hydrate; Ethyl Hydroxide; Fermentation Alcohol; Grain Alcohol Company Identification: VEE GEE Scientific, Inc. 13600 NE 126th Pl Ste A Kirkland, WA 98034 For information in North America, call: 425-823-4518

Section 2 - Composition, Information on Ingredients

CAS# Chemical Name Percent EINECS/ELINCS 64-17-5 Ethanol ca. 100 200-578-6

Hazard Symbols: F Risk Phrases: 11

Section 3 - Hazards Identification

Emergency Overview Appearance: Colorless clear liquid. Flash Point: 16.6 deg C. Warning! Flammable liquid and vapor. Causes respiratory tract irritation. May cause central nervous system depression. Causes severe eye irritation. This substance has caused adverse reproductive and fetal effects in humans. Causes moderate skin irritation. May cause liver, kidney and heart damage. Target Organs: Kidneys, heart, central nervous system, liver. Potential Health Effects Eye Contact: Causes severe eye irritation. May cause painful sensitization to light. May cause chemical conjunctivitis and corneal damage. Skin Contact: Causes moderate skin irritation. May cause cyanosis of the extremities. Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause systemic toxicity with acidosis. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. Inhalation: Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. Causes respiratory tract irritation. May cause narcotic effects in high concentration. Vapors may cause dizziness or suffocation. Chronic Exposure: May cause reproductive and fetal effects. Laboratory experiments have resulted in mutagenic effects. Animal studies have reported the development of tumors. Prolonged exposure may cause liver, kidney, and heart damage.

Section 4 - First Aid Measures

Eye Contact: Get medical aid. Gently lift eyelids and flush continuously with water. Skin Contact: Get medical aid. Wash clothing before reuse. Flush skin with plenty of soap and water. Ingestion: Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation. Notes to Physician: Treat symptomatically and supportively. Persons with skin or eye disorders or liver, kidney, chronic respiratory diseases, or central and peripheral nervous sytem diseases may be at increased risk from exposure to this substance. Antidote: None reported.

Section 5 - Fire Fighting Measures

General Information: Containers can build up pressure if exposed to heat and/or fire. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air. Vapors can travel to a source of ignition and flash back. Will burn if involved in a fire. Flammable Liquid. Can release vapors that form explosive mixtures at temperatures above the flashpoint. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Fire Extinguishing Media: For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. For large fires, use water spray, fog, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective. Do NOT use straight streams of water. Autoignition Temperature: 363°C ( 685.40°F) Flash Point: 16.6°C ( 61.88°F) Explosion Limits, lower: 3.3 vol%. Explosion Limits, upper: 19.0 vol% NFPA Rating: (estimated) Health: 2; Flammability: 3; Instability: 0

M1004 Page 1/4 Effective Date: 8/23/2004 Section 6 - Accidental Release Measures

General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. A vapor suppressing foam may be used to reduce vapors.

Section 7 - Handling and Storage

Handling: Wash thoroughly after handling. Use only in a well-ventilated area. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue (liquid and/or vapor) and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area. Do not store near perchlorates, peroxides, chromic acid or nitric acid.

Section 8 - Exposure Controls, Personal Protection

Chemical Name ACGIH NIOSH OSHA - Final PELs OSHA - Vacated Pels Ethanol 1000 ppm 1000 ppm TWA 1000 ppm TWA 1000 ppm TWA 1900 mg/m3 TWA 1900 mg/m3 TWA 1900 mg/m3 TWA 3300 ppm IDLH

Engineering Controls: Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Section 9 - Physical and Chemical Properties

Physical State: Clear liquid Boiling Point: 78° C Appearance: Colorless Freezing/Melting Point: -114.1° C Odor: Mild, pleasant Decomposition Temperature: Not available pH: Not available Solubility: Miscible Vapor Pressure: 59.3 mm Hg @ 20° C Specific Gravity/Density: 0.790 @ 20° C Vapor Density: 1.59 Molecular Formula: C2H5OH Evaporation Rate: Not available Molecular Weight: 46.0414 Viscosity: 1.200 cP @ 20° C

Section 10 - Stability and Reactivity

Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, ignition sources, excess heat, oxidizers. Incompatibilities with Other Materials: Strong oxidizing agents, acids, alkali metals, ammonia, hydrazine, peroxides, sodium, acid anhydrides, calcium hypochlorite, chromyl chloride, nitrosyl perchlorate, bromine pentafluoride, perchloric acid, silver nitrate, mercuric nitrate, potassium-tert- butoxide, magnesium perchlorate, acid chlorides, platinum, uranium hexafluoride, silver oxide, iodine heptafluoride, acetyl bromide, disulfuryl difluoride, tetrachlorosilane plus water, acetyl chloride, permanganic acid, ruthenium (VIII) oxide, uranyl perchlorate, potassium dioxide. Hazardous Decomposition Products: Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. Hazardous Polymerization: Will not occur.

Section 11 - Toxilogical Information

Carcinogenicity: ACGIH: A4 - Not Classifiable as a Human Carcinogen Epidemiology: Ethanol has been shown to produce fetotoxicity in the embryo or fetus of laboratory animals. Prenatal exposure to ethanol is associated with a distinct pattern of congenital malformations that have collecetively been termed the "fetal alcohol syndrome". Teratogenicity: Oral, Human - woman: TDLo = 41 gm/kg (female 41 week(s) after conception) Effects on Newborn - Apgar score (human only) and Effects on Newborn - other neonatal measures or effects and Effects on Newborn - drug dependence. Reproductive Effects: Intrauterine, Human - woman: TDLo = 200 mg/kg (female 5 day(s) pre-mating) Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated). Neurotoxicity: No information available. Mutagenicity: DNA Inhibition: Human, Lymphocyte = 220 mmol/L.; Cytogenetic Analysis: Human, Lymphocyte = 1160 gm/L.; Cytogenetic Analysis: Human, Fibroblast = 12000 ppm.; Cytogenetic Analysis: Human, Leukocyte = 1 pph/72H (Continuous).; Sister Chromatid Exchange: Human, Lympho- cyte = 500 ppm/72H (Continuous).

M1004 Page 2/4 Effective Date: 8/23/2004 Section 11 - Toxilogical Information (continued)

Other Studies: Standard Draize Test(Skin, rabbit) = 20 mg/24H (Moderate) Standard Draize Test: Administration into the eye (rabbit) = 500 mg (Severe).

Section 12 - Ecological Information

Environmental Toxicity: Fish: Rainbow trout: LC50 = 12900-15300 mg/L; 96 Hr; Flow-through @ 24-24.3°C Rainbow trout: LC50 = 11200 mg/L; 24 Hr; Fingerling (Unspecified) ria: Phytobacterium phosphoreum: EC50 = 34900 mg/L; 5-30 min; Microtox test 250 ppm/6hr/goldfish/lethal/fresh water. Environmental: Ethanol: In water, will volatilize and probably degrade. Physical: No information available. Other: Not expected to bioconcentrate in fish.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification. RCRA P-Series: None listed. RCRA U-Series: None listed.

Section 14 - Transport Information

US DOT Canada TDG Shipping Name Ethanol Ethanol Hazard Class 3 3 (6.1) UN Number UN1170 UN1986 Packing Group II II Other FP 18C

Section 15 - Regulatory Information

US Federal TSCA: CAS# 64-17-5 is listed on the TSCA inventory. Health & Safety Reporting List: None of the chemicals are on the Health & Safety Reporting List. Chemical Test Rules: None of the chemicals in this product are under a Chemical Test Rule. Section 12b: None of the chemicals are listed under TSCA Section 12b. TSCA Significant New Use Rule: None of the chemicals in this material have a SNUR under TSCA. SARA: CERCLA Hazardous Substances and corresponding RQs: None of the chemicals in this material have an RQ. SARA Section 302 Extremely Hazardous Substances: None of the chemicals in this product have a TPQ. SARA Codes: CAS # 64-17-5: acute, chronic, flammable. Section 313: No chemicals are reportable under Section 313. Clean Air Act: This material does not contain any hazardous air pollutants. This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors. Clean Water Act: None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA. OSHA: None of the chemicals in this product are considered highly hazardous by OSHA. STATE: Ethanol can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts. This product contains Ethanol, a chemical known to the state of California to cause birth defects or other reproductive harm. California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: F Risk Phrases: R 11 Highly flammable. Safety Phrases: S 7 Keep container tightly closed. S 9 Keep container in a well-ventilated place. S 16 Keep away from sources of ignition - No smoking. S 33 Take precautionary measures against static discharges.

M1004 Page 3/4 Effective Date: 8/23/2004 Section 15 - Regulatory Information (continued)

WGK (Water Danger/Protection): CAS# 64-17-5: 0 Canada - DSL/NDSL: CAS# 64-17-5 is listed on Canada's DSL List. Canada - WHMIS: This product has a WHMIS classification of B2, D2A. Canadian Ingredient Disclosure List: CAS# 64-17-5 is listed on Canada's Ingredient Disclosure List. Exposure Limits: CAS# 64-17-5: OEL-AUSTRALIA:TWA 1000 ppm (1900 mg/m3); OEL-BELGIUM:TWA 1000 ppm (1880 mg/m3); OEL- CZECHOSLOVAKIA:TWA 1000 mg/m3;STEL 5000 mg/m3; OEL-DENMARK:TWA 1000 ppm (1900 mg/m3); OEL-FINLAND:TWA 1000 ppm (1900 mg/ m3);STEL 1250 ppm (2400 mg/m3); OEL-FRANCE:TWA 1000 ppm (1900 mg/m3);STEL 5000 pp; OEL-GERMANY:TWA 1000 ppm (1900 mg/m3); OEL-HUNGARY:TWA 1000 mg/m3;STEL 3000 mg/m3; OEL-THE NETHERLANDS:TWA 1000 ppm (1900 mg/m3); OEL-THE PHILIPPINES:TWA 1000 ppm (1900 mg/m3); OEL-POLAND:TWA 1000 mg/m3; OEL-RUSSIA:STEL 1000 mg/m3; OEL-SWEDEN:TWA 1000 ppm (1900 mg/m3); OEL- SWITZERLAND:TWA 1000 ppm (1900 mg/m3); OEL-THAILAND:TWA 1000 ppm (1900 mg/m3); OEL-TURKEY:TWA 1000 ppm (1900 mg/m3); OEL- UNITED KINGDOM:TWA 1000 ppm (1900 mg/m3) JAN9 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV

Section 16 - Additional Information

MSDS Creation Date: 08/23/2004

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall VEE GEE Scientific be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if VEE GEE Scientific has been advised of the possibility of such damages.

M1004 Page 4/4 Effective Date: 8/23/2004