Journal of Vestibular Research. Vol. 8. No.1. pp. 81-94.1998 Copyright I!:I 1998 Elsevier Science Inc. Printed in the USA. All rights reserved 0957-4271/98 $19.00 + .00 ELSEVIER PIT S0957-4271(97)00055-4 Review SLEEP AND VESTIBULAR ADAPTATION: IMPLICATIONS FOR FUNCTION IN MICROGRAVITY J. Allan Hobson, Robert Stickgold, Edward F. Pace-Schott, and Kenneth R. Leslie Laboratory of Neurophysiology. Massachusetts Mental Health Center, Harvard Medical School, Boston, Massachusetts : : ,. "" .. 1>.. .. I. II ~ ,... "" ,... " - r' - .... .. ,... .. ... ,. .. ~ 'f''''' .. .... p .... - - • .. _.... • - _ E-mail:
[email protected] o Abstract - Optimal human performance de Introduction pends upon integrated sensorimotor and cognitive functions, both of which are known to be exquis The functions of sleep remain unknown. The itely sensitive to loss of sleep. Under the micro compelling idea that sleep subserves neuronal gravity conditions of space flight, adaptation of plasticity was first clearly articulated by Giuseppe both sensorimotor (especially vestibular) and cog nitive functions (especially orientation) must occur Moruzzi (1). This hypothesis has been tested in quickly-and be maintained-despite any concur many ways, induding the systematic perturba rent disruptions of sleep that may be caused by tion of the vestibular system. The close interre microgravity itself, or by the uncomfortable sleep lationship between the vestibular nuclei and the ing conditions of the spacecraft. It is the three-way sleep inducing structures of the pontine brain interaction between sleep quality, general work ef stem has been extensively studied by Moruzzi's ficiency, and sensorimotor integration that is the colleagues, especially Ottavio Pompeiano (2). It subject of this paper and the focus of new work in is the purpose of this paper to discuss the con our laboratory.