Cardiometab Syndr J. 2021 Mar;1(1):66-75 https://doi.org/10.51789/cmsj.2021.1.e5 pISSN 2734-1143·eISSN 2765-3749 View Point Emerging New Lipid-Lowering Therapies in the Statin Era Albert Youngwoo Jang , MD1, Sang-Ho Jo , MD, PhD2, and Kwang Kon Koh, MD, PhD1 1Division of Cardiovascular Disease, Gachon Cardiovascular Research Institute, Gachon University Gil Hospital, Incheon, Korea 2Cardiovascular Center, Hallym University Sacred Heart Hospital, Anyang, Korea Received: Dec 18, 2020 Revised: Jan 12, 2021 ABSTRACT Accepted: Jan 17, 2021 Statins have become the backbone of lipid-lowering therapy today by dramatically improving Correspondence to cardiovascular (CV) outcomes. Despite well-controlled low-density lipoprotein cholesterol Kwang Kon Koh, MD, PhD (LDL-C) through statins, up to 40% patients still experience CV diseases. New therapeutic Cardiometabolic Syndrome Unit, Division of Cardiology, Gachon University Gil Hospital, 774 agents to target such residual cholesterol risk by lowering not only LDL-C but triglyceride beon-gil 21, Namdong-daero, Namdong-gu, (TG), TG-rich lipoproteins (TRL), or lipoprotein(a) (Lp[a]) are being newly introduced. Incheon 21565, Korea. Proprotein convertase subtilisin/kexin type 9 (PCSK9) small interference RNA (siRNA) and E-mail:
[email protected] bempedoic acid therapies adding to statin therapies have shown additional improvement Copyright © 2021. Korean Society of in CV outcomes. Recent trials investigating eicosapentaenoic acid to patients with high CardioMetabolic Syndrome TG despite statin therapy have also demonstrated significant CV benefit. Antisense This is an Open Access article distributed oligonucleotide (ASO) therapies with hepatocyte-specific targeting modifications are now under the terms of the Creative Commons being newly introduced with promising lipid-lowering effects.