Table S3. Up or down regulated in Tcof1 over-expressed neuroblastoma N1E-115 cells involved in differentbiological process analysed by DAVID database P Pop Pop Fold Term Genes Bonferroni Benjamini FDR Value Hits Total Enrichment DBF4, AURKA, AURKB, CDC16, GM8416, APP, GM13337, CDKN2A,

CUL7, CASP8AP2, CDKN2C, INCENP, ATF6B, H2AFX, CCNA2, CDCA5,

GO:0007049~ 5.62E-15 ASPM, STAG1, ANAPC1, ANAPC2, GM14176, GM5951, RAN, LIG1, 611 13588 2.088741 1.87E-11 1.87E-11 1.03E-11

MAPK1, MAD2L1, LOC100044742, LOC100047340, RCC2, MAPK3,

ARL8B, ANAPC7, AKAP8, MCT

MAD1L1, DBF4, AURKA, CDC16, AURKB, GM8416, APP, INCENP,

ATF6B, GM5593, CDCA5, CCNA2, ASPM, CABLES1, STAG1, ANAPC1, GO:0000278~mitotic cell 1.12E-13 CDC6, CDK1, ANAPC2, KIF11, GM14176, ANP32B, RAN, DSN1, 244 13588 2.769043 3.70E-10 1.85E-10 2.04E-10 cycle CCNF, UBE2I, HMGA2, CDK2, CCND1, MAD2L1, RCC2,

LOC100047340, BUB1B, MAPRE2, AKAP8, HA

MAD1L1, GM15452, CDC16, AURKB, GM8416, CCNE2, CCNE1, CDC42,

CDC45, CDKN2A, CDCA7, EVI5, INCENP, GM5593, CDCA5, CCNA2,

GO:0051301~ 2.95E-12 CABLES1, ASPM, STAG1, ANAPC1, CDC7, CDC6, CDK1, ANAPC2, 281 13588 2.518933 9.72E-09 3.24E-09 5.37E-09

KIF11, GM14176, RAN, DSN1, LIG1, CCNF, UBE2I, CDK7, HMGA2,

CDK4, CDK2, MCM5, CCND

MAD1L1, CDC16, AURKB, GM8416, INCENP, ATF6B, GM5593, CDCA5,

CCNA2, ASPM, STAG1, ANAPC1, CDC6, ANAPC2, CDK1, KIF11, GO:0000087~M phase of 4.39E-12 GM14176, RAN, DSN1, CCNF, UBE2I, HMGA2, CDK2, MAD2L1, RCC2, 194 13588 2.874621 1.45E-08 3.62E-09 7.99E-09 mitotic cell cycle LOC100047340, BUB1B, MAPRE2, AKAP8, MAPRE1, ANAPC7, ARL8B,

HAUS8, HAUS3, FZR1, H

MAD1L1, CDC16, AURKB, GM8416, INCENP, ATF6B, GM5593, CDCA5,

GO:0007067~ 2.45E-11 CCNA2, ASPM, STAG1, ANAPC1, CDC6, ANAPC2, CDK1, KIF11, 190 13588 2.822249 8.08E-08 1.62E-08 4.46E-08

GM14176, RAN, DSN1, CCNF, UBE2I, HMGA2, CDK2, MAD2L1, RCC2, LOC100047340, BUB1B, MAPRE2, AKAP8, MAPRE1, ANAPC7, ARL8B,

HAUS8, HAUS3, FZR1, H

MAD1L1, CDC16, AURKB, GM8416, INCENP, ATF6B, GM5593, CDCA5,

CCNA2, ASPM, STAG1, ANAPC1, CDC6, ANAPC2, CDK1, KIF11, GO:0000280~nuclear 2.45E-11 GM14176, RAN, DSN1, CCNF, UBE2I, HMGA2, CDK2, MAD2L1, RCC2, 190 13588 2.822249 8.08E-08 1.62E-08 4.46E-08 division LOC100047340, BUB1B, MAPRE2, AKAP8, MAPRE1, ANAPC7, ARL8B,

HAUS8, HAUS3, FZR1, H

MAD1L1, DBF4, GM15452, CDC16, AURKB, GM8416, APP, INCENP,

ATF6B, GM5593, H2AFX, CDCA5, FANCA, CCNA2, CABLES1, ASPM, GO:0022403~cell cycle 6.45E-11 STAG1, ANAPC1, CDC6, CDK1, ANAPC2, KIF11, GM14176, ANP32B, 328 13588 2.288775 2.13E-07 3.54E-08 1.17E-07 phase RAN, DSN1, CCNF, UBE2I, HMGA2, CDK2, KLHDC3, CCND1, MAD2L1,

RCC2, LOC100047340,

MAD1L1, CDC16, AURKB, GM8416, INCENP, ATF6B, GM5593, CDCA5,

CCNA2, ASPM, STAG1, ANAPC1, CDC6, ANAPC2, CDK1, KIF11, GO:0048285~organelle 9.86E-11 GM14176, RAN, DSN1, CCNF, UBE2I, HMGA2, CDK2, MAD2L1, RCC2, 197 13588 2.721966 3.25E-07 4.64E-08 1.79E-07 fission LOC100047340, BUB1B, MAPRE2, AKAP8, MAPRE1, ANAPC7, ARL8B,

HAUS8, HAUS3, FZR1, H

LOC630896, MAD1L1, DBF4, GM15452, CDC16, AURKB, GM8416,

GM8096, APP, CGREF1, GM13337, CDKN2A, INCENP, ATF6B, GO:0022402~cell cycle 1.83E-10 GM5593, H2AFX, CCNA2, CDCA5, FANCA, CABLES1, ASPM, STAG1, 393 13588 2.128536 6.03E-07 7.54E-08 3.33E-07 process ANAPC1, CDC6, ANAPC2, CDK1, KIF11, GM14176, ANP32B, DSN1,

RAN, CCNF, UBE2I, HMGA2, CDK2,

MAD1L1, GM15452, CDC16, AURKB, GM8416, INCENP, ATF6B,

GM5593, H2AFX, CDCA5, FANCA, CCNA2, ASPM, STAG1, ANAPC1, GO:0000279~M phase 2.29E-09 283 13588 2.273755 7.55E-06 8.39E-07 4.17E-06 CDC6, CDK1, ANAPC2, KIF11, GM14176, RAN, DSN1, CCNF, UBE2I,

HMGA2, CDK2, KLHDC3, MAD2L1, RCC2, LOC100047340, BUB1B, MAPRE2, AKAP8, HAUS8, ARL8B,

HMGN1, MORF4L1, KIF22, MORF4L2, HNRPLL, FANCM, GPX1,

ANKRD17, CASP3, CASP9, MAP1LC3A, ATG5, COL4A3BP, HMOX1, GO:0033554~cellular 1.03E-07 AEN, GPX4, GPX3, GM2992, H2AFX, FANCG, MAPKBP1, MAP2K7, 404 13588 1.911305 3.38E-04 3.38E-05 1.87E-04 response to stress FANCA, FANCC, CLN3, CDK1, DDB1, LIG1, AARS, CCDC47, GM5806,

GTF2H2, MAPK1, CCND1, BTG2, LO

DBF4, CITED2, CDT1, CSNK2A2, CCNE2, CDC42, CCNE1, APP,

CASP3, CDKN2A, CUL7, ATF6B, CDK5RAP3, H2AFX, LTB, CABLES1, GO:0051726~regulation of 1.40E-07 CDK1, GTPBP4, GM7334, CCNI, LOC100046019, HERC2, CDK4, 214 13588 2.305276 4.62E-04 4.20E-05 2.55E-04 cell cycle HRAS1, PURA, CCND1, MAD2L1, HMG1L1, BTG3, GM5853,

LOC637733, CDK11B, GM7468, BAT2, LOC

GO:0006270~DNA 2.11E-07 CCNE2, CCNE1, CDC45, MCM7, MCM2, MCM3, MCM4, MCM5, MCM6 10 13588 9.652092 6.95E-04 5.79E-05 3.84E-04 replication initiation

MORF4L1, HMGN1, MORF4L2, CBX4, GM13646, INO80, CBX1, CBX8,

CBX6, CBX5, HIST1H2BP, HIST1H2BM, HIST1H2BN, H2AFV, GO:0006325~ 3.12E-07 HIST1H2BL, HIST1H2BJ, H2AFZ, H2AFX, MTA2, LOC100045490, 315 13588 2.008725 0.001026 7.90E-05 5.67E-04 organization HMG20A, HDAC11, H2AFJ, KDM2B, A730008H23RIK, GM11277,

GM11276, ASF1B, DNMT3B, ASF1A, GM1

HMGN1, MORF4L1, MORF4L2, CBX4, GM13646, INO80, CBX1, CBX8,

CBX6, CBX5, HIST1H2BP, HIST1H2BM, HIST1H2BN, H2AFV, GO:0051276~ 4.72E-07 HIST1H2BL, ATF6B, HIST1H2BJ, H2AFZ, H2AFX, ACIN1, CDCA5, 404 13588 1.858213 0.001553 1.11E-04 8.59E-04 organization MTA2, LOC100045490, HMG20A, HDAC11, H2AFJ, KDM2B, MAD2L1,

AKAP8, BLM, A730008H23RIK, GM

MORF4L1, CBX4, GM13646, CBX1, CBX8, CBX6, CBX5, HIST1H2BP, GO:0006333~chromatin 4.97E-07 LOC100047898, HIST1H2BM, HIST1H2BN, H2AFV, HIST1H2BL, 109 13588 2.85332 0.001636 1.09E-04 9.04E-04 assembly or disassembly GM9531, HIST1H2BJ, H2AFZ, H2AFX, LOC100045490, MCM2, H2AFJ, NPTXR, HIST1H2AB, HIST1H2AC, HIST1H2AG, HIST1H2AD,

A730008H23RIK, HIST1H2AE, HIST2

AURKA, LPAR2, AURKB, GM8416, MAP3K7, CSNK2A2, APP, MAP3K5,

MAP2K7, EGFR, TYRO3, MAPKSP1, CSNK1G1, LOC100046344, GO:0016310~phosphorylat 8.22E-06 MAP4K3, MAP4K4, MAPK1, NME1, MAPK3, CARTPT, MST1R, EIF2AK3, 718 13588 1.538479 0.026717 0.001691 0.014957 ion GNAI2, ERBB3, CHEK1, ADRBK1, ATP6V1B2, ATP6V0B, CD74, FGD4,

MDFI, ATR, HGF, GLYCTK,

ATP5D, FIGNL1, ATP10A, ATP5G2, ATP6V1B2, PNP, ATP5G3,

ATP6V0B, CANT1, ATP2B2, DHODH, ENTPD2, IMPDH2, GO:0009259~ribonucleoti 9.03E-06 LOC100045567, GM5081, ATP1A3, ATP1A1, AMPD2, ATP13A2, 125 13588 2.488095 0.029301 0.001748 0.016425 de metabolic process AMPD3, LOC100046344, ATP6V1D, GART, ATP6V1A, ATP2C2,

ATP6V0E2, NME1, ATP8A2, ADSL, ATP5A1, ATP6V0A2,

STYX, LPAR2, AURKA, AURKB, GM8416, CSNK2A2, MAP3K7, APP,

MAP3K5, MAP2K7, EGFR, TYRO3, MAPKSP1, CSNK1G1, GM5951, GO:0006796~phosphate 1.20E-05 LOC100046344, MAP4K3, MAPK1, MAP4K4, LOC100044742, NME1, 866 13588 1.473696 0.038636 0.002187 0.021761 metabolic process MAPK3, CARTPT, MST1R, EIF2AK3, GM8783, GNAI2, ERBB3,

DUSP10, CHEK1, ADRBK1, ATP6V1B2,

STYX, LPAR2, AURKA, AURKB, GM8416, CSNK2A2, MAP3K7, APP,

MAP3K5, MAP2K7, EGFR, TYRO3, MAPKSP1, CSNK1G1, GM5951, GO:0006793~phosphorus 1.20E-05 LOC100046344, MAP4K3, MAPK1, MAP4K4, LOC100044742, NME1, 866 13588 1.473696 0.038636 0.002187 0.021761 metabolic process MAPK3, CARTPT, MST1R, EIF2AK3, GM8783, GNAI2, ERBB3,

DUSP10, CHEK1, ADRBK1, ATP6V1B2,

GO:0034404~nucleobase, ATP5D, CTPS, G6PDX, ATP10A, DTYMK, ATP5G2, CTPS2, CAD,

nucleoside and ATP6V1B2, ATP5G3, PNP, ATP6V0B, ATP2B2, DHODH, GUCY1A3, 1.81E-05 179 13588 2.156892 0.05785 0.003131 0.032909 nucleotide biosynthetic IMPDH2, ADSSL1, LOC100045567, GM5081, ATP1A3, ATP1A1,

process AMPD2, ATP13A2, AMPD3, ATP6V1D, LOC100046344, GART, ATP6V1A, ATP2C2, DHFR, ATP6V0E2, NME1,

ATP5D, CTPS, G6PDX, ATP10A, DTYMK, ATP5G2, CTPS2, CAD, GO:0034654~nucleobase, ATP6V1B2, ATP5G3, PNP, ATP6V0B, ATP2B2, DHODH, GUCY1A3, nucleoside, nucleotide 1.81E-05 IMPDH2, ADSSL1, LOC100045567, GM5081, ATP1A3, ATP1A1, 179 13588 2.156892 0.05785 0.003131 0.032909 and nucleic acid AMPD2, ATP13A2, AMPD3, ATP6V1D, LOC100046344, GART, biosynthetic process ATP6V1A, ATP2C2, DHFR, ATP6V0E2, NME1,

ATP5D, LOC630896, CTPS, DTYMK, ATP10A, G6PDX, CAD, PNP,

GO:0044271~nitrogen GM8096, GOT2, ATP2B2, GM13337, GATA3, GUCY1A3, CHRNA7,

compound biosynthetic 2.01E-05 GM6742, ENOPH1, IMPDH2, HSP90AA1, ATP6V1D, LOC100046344, 302 13588 1.846611 0.0641 0.003307 0.036584

process ATP6V1A, ATP2C2, NME1, ADK, ADSL, FLAD1, SMS, PRPS1,

GM7669, ATP5G2, AZIN1, CTPS2, ATP6

ATP5D, CTPS, G6PDX, ATP10A, DTYMK, ATP5G2, CTPS2, ATP6V1B2,

ATP5G3, PNP, ATP6V0B, ATP2B2, DHODH, GUCY1A3, IMPDH2, GO:0009165~nucleotide 2.40E-05 ADSSL1, LOC100045567, GM5081, ATP1A3, ATP1A1, AMPD2, 174 13588 2.157236 0.076163 0.003765 0.043747 biosynthetic process ATP13A2, AMPD3, ATP6V1D, LOC100046344, GART, ATP6V1A,

ATP2C2, DHFR, ATP6V0E2, NME1, ADK,

ATP5D, ATP10A, ATP5G2, ATP6V1B2, PNP, ATP5G3, ATP6V0B,

ATP2B2, DHODH, IMPDH2, LOC100045567, GM5081, ATP1A3, GO:0009260~ribonucleoti 2.43E-05 ATP1A1, AMPD2, LOC100046344, ATP6V1D, AMPD3, ATP13A2, 111 13588 2.512056 0.076987 0.003635 0.04424 de biosynthetic process GART, ATP6V1A, ATP2C2, ATP6V0E2, NME1, ATP8A2, ADSL,

ATP5A1, ATP6V0A2, PRPS1

GO:0007033~vacuole CLN3, HEXB, ACP2, FIG4, HOOK2, MAN2A1, MAP1LC3A, AKTIP, 3.19E-05 34 13588 4.100562 0.09964 0.004553 0.057957 organization ATG5, LYST, GAA, CLN5, GBA

GM13646, HIST1H2BP, LOC100047898, HIST1H2BM, HIST1H2BN,

GO:0006323~DNA packaging 4.22E-05 H2AFV, HIST1H2BL, GM9531, HIST1H2BJ, ATF6B, H2AFZ, H2AFX, 101 13588 2.548407 0.129828 0.005778 0.076782

ACIN1, CDCA5, MTA2, LOC100045490, H2AFJ, MCM2, AKAP8, HIST1H2AB, HIST1H2AC, HIST1H2AG, HIST1H2AD, HIST1H2AE,

A730008H23RIK, HIST2H3C1, GM1127

ATP5D, FIGNL1, ATP10A, ATP5G2, ATP6V1B2, PNP, ATP5G3,

GO:0009150~purine ATP6V0B, ATP2B2, ENTPD2, IMPDH2, LOC100045567, ATP1A3, ribonucleotide metabolic 8.28E-05 ATP1A1, AMPD2, LOC100046344, ATP6V1D, AMPD3, ATP13A2, 119 13588 2.343178 0.238639 0.010847 0.150482

process GART, ATP6V1A, ATP2C2, ATP6V0E2, NME1, ATP8A2, ADSL,

ATP5A1, ATP6V0A2

HMGN1, MORF4L1, KIF22, FHIT, LOC100044969, DBF4, MORF4L2,

BNIP3, CTCF, CDT1, CCNE2, FANCM, CCNE1, ANKRD17, CASP3, GO:0006259~DNA metabolic 1.04E-04 CDC45, MCM7, GM2992, H2AFX, FANCG, FANCA, FANCC, CDC6, 421 13588 1.630335 0.289071 0.013037 0.188273 process CCDC88A, MELA, DDB1, LIG1, MCM2, MCM3, GM5806, MCM4, MCM5,

GTF2H2, DNASE2B, MCM6, LOC1

ATP5D, ATP10A, ATP5G2, ATP6V1B2, ATP5G3, PNP, ATP6V0B, GO:0009152~purine ATP2B2, IMPDH2, LOC100045567, ATP1A3, ATP1A1, AMPD2, ribonucleotide 1.09E-04 107 13588 2.405506 0.301568 0.013205 0.198049 ATP6V1D, AMPD3, ATP13A2, LOC100046344, GART, ATP6V1A, biosynthetic process ATP2C2, ATP6V0E2, NME1, ATP8A2, ADSL, ATP5A1, ATP6V0A2

ACVRL1, PINK1, LPAR2, CAD, AURKA, AURKB, GM8416, CAMKK2,

CSNK2A2, MAP3K7, CCNE1, ADCK1, APP, MAP3K5, EEF2K, GM5593, GO:0006468~ amino 1.14E-04 FERT2, MASTL, CSK, MAPKBP1, MAP2K7, CHUK, AKT3, CDK14, 640 13588 1.491382 0.313171 0.013327 0.207283 acid phosphorylation EGFR, CDC7, TYRO3, IRAK1, CDK1, MAPKSP1, LIMK2, CSNK1G1,

LYN, DGUOK, CDK7, CDK4, DAP

IMPACT, LPAR2, CDC42, MAP3K5, APP, CASP3, CDKN2A, CDK5RAP3,

MLST8, FGF1, MAPKBP1, CEACAM1, IBTK, EGFR, IRAK1, GTPBP4, GO:0042325~regulation of 1.18E-04 MAPKSP1, CCDC88A, LYN, LOC100046019, CARD10, ACVR2A, 290 13588 1.775097 0.322264 0.013324 0.214629 phosphorylation ACVR2B, HMG1L1, CD81, GM5853, CARTPT, LOC637733, GM7468,

LOC100048378, LOC100048076, GM13646, HIST1H2BP, LOC100047898, HIST1H2BM, HIST1H2BN,

H2AFV, HIST1H2BL, GM9531, HIST1H2BJ, H2AFZ, H2AFX, GO:0031497~chromatin 1.38E-04 LOC100045490, MCM2, H2AFJ, HIST1H2AB, HIST1H2AC, 75 13588 2.716885 0.364981 0.015023 0.250505 assembly HIST1H2AG, HIST1H2AD, HIST1H2AE, A730008H23RIK,

HIST2H3C1, GM11277, GM11276, SET, HJURP, ASF1B, ASF

GM13646, HIST1H2BP, LOC100047898, HIST1H2BM, HIST1H2BN,

H2AFV, HIST1H2BL, GM9531, HIST1H2BJ, H2AFZ, H2AFX, GO:0065004~protein-DNA 1.65E-04 LOC100045490, MCM2, H2AFJ, HIST1H2AB, HIST1H2AC, 76 13588 2.681137 0.419587 0.017396 0.300032 complex assembly HIST1H2AG, HIST1H2AD, HIST1H2AE, A730008H23RIK,

HIST2H3C1, GM11277, GM11276, SET, HJURP, ASF1B, ASF

GO:0006261~DNA-dependen LOC100044969, BRCA2, MCM2, MCM3, MCM4, MCM5, MCM6, CCNE2, 1.67E-04 34 13588 3.785134 0.423722 0.017076 0.30397 t DNA replication DNA2, CCNE1, CDC45, MCM7, TOP3A

MORF4L1, HMGN1, KIF22, MORF4L2, ANKRD17, FANCM, CASP3,

CASP9, HMOX1, AEN, GM2992, H2AFX, FANCG, FANCA, FANCC, GO:0006974~response to 1.81E-04 CDK1, LIG1, DDB1, GM5806, GTF2H2, MAPK1, CCND1, BTG2, 287 13588 1.756285 0.449016 0.0179 0.328683 DNA damage stimulus MAPK3, LOC100044391, MCTS1, HMGB2, BLM, BCCIP, CHEK1,

GM7862, ERCC3, APEX1, ASF1A, GM11663,

FAM33A, GM14176, DSN1, A730008H23RIK, KIF18A, CENPF, GO:0007059~.92E-04 UBE2I, BIRC5, CTCF, CENPH, LOC100044900, MAD2L1, HJURP, 64 13588 2.848708 0.469592 0.018477 0.349633 segregation INCENP, ATF6B, AKAP8, ARL8B, CDCA5, BUB3, STAG1

GO:0031214~biomineral ATP2B2, AMBN, BGLAP, DSPP, BMP2, BGLAP-RS1, ENPP1, GLA, 2.24E-04 35 13588 3.676987 0.521337 0.02083 0.406116 formation ENAM, EIF2AK3, MMP13, BGLAP2

GO:0042475~odontogenesi BMP4, BMP2, FST, LEF1, DLX2, ACVR2B, DLX1, AMBN, ITGA6, BAX, s of dentine-containing 2.48E-04 41 13588 3.400466 0.558646 0.022464 0.450747 BMP7, CHUK, BMPR1A tooth

GO:0019220~regulation of 2.84E-04 IMPACT, LPAR2, CDC42, MAP3K5, APP, CASP3, CDKN2A, CDK5RAP3, 301 13588 1.710227 0.608087 0.024999 0.516053 phosphate metabolic MLST8, FGF1, MAPKBP1, CEACAM1, IBTK, EGFR, IRAK1, GTPBP4,

process MAPKSP1, CCDC88A, LYN, LOC100046019, CARD10, ACVR2A,

ACVR2B, HMG1L1, CD81, GM5853, CARTPT, LOC637733, GM7468,

LOC100048378, LOC100048076,

IMPACT, LPAR2, CDC42, MAP3K5, APP, CASP3, CDKN2A, CDK5RAP3,

GO:0051174~regulation of MLST8, FGF1, MAPKBP1, CEACAM1, IBTK, EGFR, IRAK1, GTPBP4,

phosphorus metabolic 2.84E-04 MAPKSP1, CCDC88A, LYN, LOC100046019, CARD10, ACVR2A, 301 13588 1.710227 0.608087 0.024999 0.516053

process ACVR2B, HMG1L1, CD81, GM5853, CARTPT, LOC637733, GM7468,

LOC100048378, LOC100048076,

HIST1H2AB, HIST1H2AC, HIST1H2AG, HIST1H2AD,

A730008H23RIK, HIST1H2AE, GM13646, HIST2H3C1, GM11277, GO:0006334~ 3.08E-04 GM11276, LOC100047898, HIST1H2BP, HIST1H2BM, SET, 73 13588 2.644409 0.637965 0.026383 0.559618 assembly HIST1H2BN, H2AFV, HJURP, HIST1H2BL, GM9531, HIST1H2BJ,

H2AFZ, H2AFX, ASF1B, ASF1A, HIST1H2BB, HIST2H3B, HI

EIF6, LOC100047658, GM10159, F13A1, EIF5, EIF5A, GM3379,

WARS, LOC100048462, GM10259, RPL10, EIF2B2, RPS27A, MRPL2,

GO:0006412~translation 3.17E-04 MRPL4, CARS, MRPL3, GM10184, AARS, GM14173, GM6834, MRPS5, 319 13588 1.680963 0.648517 0.026454 0.575863

EEF2, MRPS7, MRPS2, EARS2, GM4613, EIF4G2, MRPS18C,

MRPS18B, LOC100048105, EIF2S

LOC100044207, BNIP3, LOC100044385, PNP, GDNF, CIAPIN1,

CITED2, CTNNBL1, MAP3K7, BAG4, GPX1, CASP3, CDKN2A, GO:0042981~regulation of 3.38E-04 CASP8AP2, CUL7, CASP9, ATG5, HMOX1, AEN, DDX20, CASP1, LTB, 553 13588 1.493291 0.671982 0.027482 0.613799 DEDD2, API5, CLN3, AARS, CYCS, HRK, ADNP, DAPK3, CARD10,

HRAS1, BTG2, EIF2AK3, BAT2, ALO

GO:0022613~ribonucleopr EIF6, GM5616, GAR1, NHP2L1, LOC100044829, ERI1, MINA, 3.40E-04 137 13588 2.113597 0.673711 0.026947 0.616699 otein complex biogenesis DIMT1, EIF3A, CDKN2A, CLP1, BRIX1, GEMIN8, LSM2, GEMIN6, IMP4, FTSJ3, GTPBP4, EXOSC9, EXOSC7, EMG1, EXOSC4, BYSL,

EXOSC2, MBNL1, FBL, MRTO4, DIS3, CELF1

ATP5D, ATP10A, ATP5G2, ATP6V1B2, PNP, ATP5G3, ATP6V0B,

GO:0006164~purine ATP2B2, GUCY1A3, IMPDH2, ADSSL1, LOC100045567, ATP1A3, nucleotide biosynthetic 3.40E-04 ATP1A1, AMPD2, LOC100046344, ATP6V1D, AMPD3, ATP13A2, 137 13588 2.113597 0.673711 0.026947 0.616699

process GART, ATP6V1A, ATP2C2, ATP6V0E2, NME1, ADK, ATP8A2, ADSL,

ATP5A1, ATP6V0A2

COPA, GNPDA1, MSR1, AP1G1, CLTC, CD47, CDC42, COPB2, HOOK2,

AP2B1, APP, CLEC4F, GSN, CHRNA7, CAP1, LBP, GOLGA5, KDELR1, GO:0016192~vesicle-medi 3.58E-04 COX16, KDELR3, CLN3, DBNL, LOC100046344, LDLRAP1, FLNA, 466 13588 1.541941 0.692581 0.027694 0.649395 ated transport BCAP31, HRAS1, ERGIC3, KIF1C, GM10698, COPG2, NME1, ARCN1,

CUX1, BIN1, COPG, CO

ATP5D, FIGNL1, ATP10A, ATP5G2, ATP6V1B2, PNP, ATP5G3,

GO:0006163~purine ATP6V0B, ATP2B2, GUCY1A3, ENTPD2, IMPDH2, ADSSL1,

nucleotide metabolic 3.59E-04 LOC100045567, ATP1A3, ATP1A1, DGUOK, AMPD2, ATP13A2, 160 13588 2.010852 0.693562 0.027131 0.651149

process LOC100046344, ATP6V1D, AMPD3, GART, ATP6V1A, ATP2C2,

ATP6V0E2, NME1, ADK, ATP8A2, ADSL, ATP5A1, AT

LOC100044207, BNIP3, LOC100044385, PNP, GDNF, CIAPIN1,

CITED2, CTNNBL1, MAP3K7, BAG4, GPX1, CASP3, CDKN2A, GO:0010941~regulation of 3.61E-04 CASP8AP2, CUL7, CASP9, ATG5, HMOX1, AEN, DDX20, CASP1, LTB, 563 13588 1.485816 0.695665 0.026675 0.654928 cell death DEDD2, API5, CLN3, AARS, CYCS, HRK, ADNP, DAPK3, CARD10,

HRAS1, BTG2, EIF2AK3, BAT2, ALO

ALDH8A1, GFER, FDFT1, GM13337, IDH3G, HADH, ALDH6A1,

GO:0055114~oxidation CYP2C55, CYP3A13, FA2H, CYP2B10, KDM2B, F5, GULO, MDH2, 3.84E-04 672 13588 1.436323 0.717739 0.027718 0.696237 reduction ME2, GLUD1, MOSC2, HADHA, NPHP3, DHODH, IDH2, ERO1L, GPD2,

GPD1, GM9252, LOC100045360, CRYZ, CYB561, GM9347, DHFR, DOHH, ACAD11, CYB5R3, LOC630896

LOC100044341, IMPACT, HR, CBX4, BNIP3, CTCF, CBX1, CBX8, GO:0010605~negative CITED2, CBX5, CDT1, EIF4EBP1, CDKN2A, ATG5, CLP1, ATF6B, regulation of 4.83E-04 DDX20, BHLHE41, LAG3, EGR1, IBTK, CLN3, CTBP1, GTPBP4, 506 13588 1.504828 0.796025 0.03397 0.874248 macromolecule metabolic MTA2, LEF1, FLNA, PURA, COBRA1, HHEX, BPTF, CUX1, EIF2AK3, process MTDH, GCLC, BLM, ERI1, HAT1

LOC100044207, BNIP3, LOC100044385, PNP, GDNF, CIAPIN1,

CITED2, CTNNBL1, MAP3K7, BAG4, GPX1, CASP3, CDKN2A, GO:0043067~regulation of 4.97E-04 CASP8AP2, CUL7, CASP9, ATG5, HMOX1, AEN, DDX20, CASP1, LTB, 560 13588 1.474625 0.80528 0.034214 0.89967 programmed cell death DEDD2, API5, CLN3, AARS, CYCS, HRK, ADNP, DAPK3, CARD10,

HRAS1, BTG2, EIF2AK3, BAT2, ALO

MEF2A, LOC100044207, BNIP3, EIF5A, TNFSF13, TNFSF12,

CIAPIN1, CTNNBL1, CLPTM1L, GPX1, BAG4, APP, CASP3, MAP3K5,

GO:0008219~cell death 5.04E-04 CDKN2A, CASP8AP2, CUL7, CASP9, GATA6, AEN, LOC100046998, 507 13588 1.50186 0.809702 0.033975 0.912243

BAG2, ACIN1, CASP1, LTB, DEDD2, LUC7L3, CUL1, API5, OPA1,

FAM82A2, CYCS, HRK, TBRG4, G

HIST1H2AB, HIST1H2AC, HIST1H2AG, HIST1H2AD,

A730008H23RIK, HIST1H2AE, GM13646, HIST2H3C1, GM11277, GO:0034728~nucleosome 5.10E-04 GM11276, LOC100047898, HIST1H2BP, HIST1H2BM, SET, 76 13588 2.540024 0.813907 0.033734 0.924469 organization HIST1H2BN, H2AFV, HJURP, HIST1H2BL, GM9531, HIST1H2BJ,

H2AFZ, H2AFX, ASF1B, ASF1A, HIST1H2BB, HIST2H3B, HI

GO:0007040~ 5.39E-04 CLN3, HOOK2, AKTIP, LYST, HEXB, GAA, ACP2, CLN5, GBA 22 13588 4.387314 0.830851 0.034915 0.976699 organization

MORF4L1, DPF3, EZH1, A730008H23RIK, EZH2, MORF4L2, CBX4, GO:0016568~chromatin 5.81E-04 HAT1, INO80, BNIP3, CTCF, CBX8, CBX6, HJURP, CHD1, KDM3A, 236 13588 1.772277 0.852556 0.03684 1.051785 modification ACTL6A, ASF1B, KDM5A, DNMT3B, KDM5B, ASF1A, HELLS, CHD4, CBX6-NPTXR, DNMT3A, MTA2, GM5521, HMG20A, HDAC11, DAPK3,

GSG2, MSL3, RNF8, KDM2B, N

EIF6, ENAH, GM13646, HIST1H2BP, LOC100047898, HIST1H2BM,

GO:0034621~cellular HIST1H2BN, H2AFV, GSN, HIST1H2BL, GM9531, CLP1, HIST1H2BJ,

macromolecular complex 6.23E-04 H2AFZ, H2AFX, LSM2, MTERFD3, KPNB1, LOC100045490, IPO8, 245 13588 1.750946 0.871736 0.038724 1.127917

subunit organization MBNL1, MCM2, H2AFJ, FLNA, IPO5, CELF1, HIST1H2AB,

HIST1H2AC, HIST1H2AG, HIST1H2AD,

GO:0042476~odontogenesi BMP4, BMP2, FST, LEF1, DLX2, ACVR2B, DLX1, AMBN, ITGA6, BAX, 6.37E-04 45 13588 3.098202 0.877505 0.038842 1.15305 s BMP7, CHUK, BMPR1A

DLC1, HMGN1, IL6ST, TNFSF13, TNFSF12, PNP, CDKN2A, CDCA7,

CDKN2C, GATA3, LOC100047138, ATF6B, GATA4, GM6742, EGFR, GO:0042127~regulation of 6.38E-04 GTPBP4, LOC100046019, HRAS1, HHEX, GM7468, BAT2, HMGB1, 538 13588 1.475123 0.877815 0.038182 1.154431 cell proliferation CAV2, CNBP, DERL2, GNAI2, BLM, ADORA2A, IFITM3, CLU, IFI30,

ITGB1, LHX1, GM11663, BM

ATP5D, FIGNL1, LOC100045567, ATP10A, ATP1A3, ATP1A1, GO:0009144~purine ATP5G2, ATP6V1B2, DGUOK, LOC100046344, ATP13A2, PNP, nucleoside triphosphate 6.82E-04 106 13588 2.225849 0.894209 0.040019 1.233057 ATP5G3, ATP6V1D, ATP6V0B, ATP6V1A, ATP2B2, ATP2C2, metabolic process ATP6V0E2, NME1, ADK, ATP8A2, ATP5A1, ATP6V0A2

MSH6, GTPBP4, CCDC88A, BLM, LOC100045567, GMNN, NDFIP1, GO:0051052~regulation of 6.98E-04 BRCA2, TNFSF13, TNFSF12, PNP, CDT1, RNF8, LOC100046168, 58 13588 2.77359 0.899748 0.040241 1.262391 DNA metabolic process DNA2, BRE, FTSJD2, TNFSF12-TNFSF13, ID3, APBB1

EIF6, ENAH, GM13646, H2-D1, LNX1, LOC100047898, HIST1H2BP,

GO:0043933~macromolecul GTF2E2, HIST1H2BM, HIST1H2BN, H2AFV, HIST1H2BL, GSN, CLP1,

ar complex subunit 8.38E-04 GM9531, GPX3, HIST1H2BJ, GOPC, H2AFZ, H2AFX, LSM2, KPNB1, 367 13588 1.577999 0.936875 0.047312 1.514341

organization MTERFD3, DCTPP1, TAF4A, LOC100045490, MBNL1, H2AFJ, IPO8,

MCM2, FLNA, IPO5, CEL ATP5D, FIGNL1, ATP10A, ATP5G2, ATP6V1B2, ATP5G3, PNP, GO:0009141~nucleoside ATP6V0B, ATP2B2, LOC100045567, ATP1A3, ATP1A1, DGUOK, triphosphate metabolic 8.43E-04 115 13588 2.144909 0.937871 0.046777 1.522995 ATP6V1D, ATP13A2, LOC100046344, ATP6V1A, ATP2C2, ATP6V0E2, process NME1, ADK, ATP8A2, ATP5A1, ATP6V0A2, DUT

MEF2A, LOC100044207, EIF5A, BNIP3, TNFSF13, TNFSF12,

CIAPIN1, CTNNBL1, CLPTM1L, GPX1, BAG4, APP, CASP3, MAP3K5, GO:0012501~programmed 8.90E-04 CDKN2A, CASP8AP2, CASP9, CUL7, GATA6, AEN, LOC100046998, 473 13588 1.496448 0.946757 0.048495 1.606907 cell death BAG2, ACIN1, CASP1, LTB, DEDD2, LUC7L3, CUL1, API5, OPA1,

FAM82A2, CYCS, HRK, TBRG4, D

ATP5D, LOC100045567, ATP10A, ATP1A3, ATP1A1, ATP5G2, GO:0009145~purine ATP6V1B2, LOC100046344, ATP13A2, PNP, ATP5G3, ATP6V1D, nucleoside triphosphate 9.35E-04 94 13588 2.281818 0.954046 0.05004 1.686891 ATP6V0B, ATP6V1A, ATP2B2, ATP2C2, ATP6V0E2, NME1, ADK, biosynthetic process ATP8A2, ATP5A1, ATP6V0A2

MEF2A, LOC100044207, EIF5A, BNIP3, TNFSF13, TNFSF12,

CIAPIN1, CTNNBL1, CLPTM1L, GPX1, BAG4, APP, CASP3, MAP3K5,

GO:0006915~apoptosis 9.36E-04 CDKN2A, CASP8AP2, CASP9, CUL7, GATA6, AEN, LOC100046998, 465 13588 1.49913 0.95427 0.049316 1.689541

BAG2, ACIN1, CASP1, LTB, DEDD2, LUC7L3, CUL1, API5, OPA1,

FAM82A2, CYCS, HRK, TBRG4, D

EGR1, DERL2, HSP90AA1, AARS, DEK, CLIC1, EDEM3, MANF, FOS, GO:0051789~response to 9.48E-04 CCND1, ID2, ID1, D17H6S56E-3, ATF6B, HSPA4L, ERO1L, 87 13588 2.342142 0.956077 0.049159 1.711438 protein stimulus CREB3L3, ID3, EIF2AK3

MEF2A, LOC100044207, BNIP3, EIF5A, TNFSF13, TNFSF12,

CIAPIN1, CTNNBL1, CLPTM1L, GPX1, BAG4, APP, CASP3, MAP3K5,

GO:0016265~death 9.63E-04 CDKN2A, CASP8AP2, CUL7, CASP9, GATA6, AEN, LOC100046998, 519 13588 1.467134 0.958104 0.049111 1.737083

BAG2, ACIN1, CASP1, LTB, DEDD2, LUC7L3, CUL1, API5, OPA1,

FAM82A2, CYCS, HRK, TBRG4, G ATP5D, LOC100045567, ATP10A, ATP1A3, ATP1A1, ATP5G2, GO:0009142~nucleoside ATP6V1B2, LOC100046344, ATP13A2, PNP, ATP5G3, ATP6V1D, triphosphate 0.001068 95 13588 2.257799 0.970434 0.053531 1.926076 ATP6V0B, ATP6V1A, ATP2B2, ATP2C2, ATP6V0E2, NME1, ADK, biosynthetic process ATP8A2, ATP5A1, ATP6V0A2

GO:0016052~carbohydrate ALDOART1, ALDOA, GPD1, HYAL2, GNPDA1, GM2A, HKDC1, ALDOC, 0.001099 81 13588 2.383232 0.973268 0.054198 1.980656 catabolic process HEXB, CHI3L1, BAD, GPI1, CHID1, GAA, ENO2, CTBS, MDH2, ENO1

ALDH6A1, CTBP1, LOC100045360, BNIP3, LOC100044204, GO:0045444~fat cell 0.00119 SELENBP1, LPIN1, GPX1, BBS2, LAMA4, CCND1, ITGA6, GSK3B, 61 13588 2.637183 0.980185 0.057683 2.142624 differentiation MKKS, ERO1L, EIF2AK3, MED1

HMGB1, GM12568, DBF4, GM10075, CDT1, CDC42, APP, CUL7,

GM5937, ATF6B, LTB, CDK1, GM7334, LOC100046019, CENPF, GO:0007346~regulation of 0.001218 BRCA2, BIRC5, HERC2, PURA, CCND1, LOC100048453, MAD2L1, 96 13588 2.23428 0.981957 0.058165 2.193248 mitotic cell cycle HMG1L1, BTG3, GM5853, LOC637733, CDK11B, GM7468, GM15387,

APBB1, BAT2, LOC100045958, LOC1

GO:0051329~ of ANP32B, DBF4, CENPF, CHEK1, BIRC5, ITGB1, APP, CCND1, 0.001443 49 13588 2.845288 0.991395 0.067543 2.592405 mitotic cell cycle CDC123, CAMK2D, CAMK2B, CDCA5, CABLES1

COPA, ENAH, AP1G1, BNIP3, LOC100044514, CLTC, CDC42, COPB2,

IMMP2L, HOOK2, AP2B1, APP, DDX25, GM10259, GLE1, GOLGA5, GO:0046907~intracellula 0.001652 KPNB1, COX16, KIF5B, RAN, GM10184, GM9797, ARNTL, IPO8, 431 13588 1.492976 0.995682 0.075878 2.962662 r transport TIMM23, FLNA, BCAP31, ERGIC3, KIF1C, MFN2, COPG2, KIF1B,

AAAS, TIMM8A1, ATG4B, IPO

EIF6, GM13646, HIST1H2BP, LOC100047898, HIST1H2BM,

GO:0034622~cellular HIST1H2BN, H2AFV, GSN, HIST1H2BL, GM9531, CLP1, HIST1H2BJ,

macromolecular complex 0.001773 H2AFZ, H2AFX, LSM2, KPNB1, LOC100045490, IPO8, MCM2, H2AFJ, 217 13588 1.729766 0.997103 0.080098 3.176447

assembly MBNL1, FLNA, IPO5, CELF1, HIST1H2AB, HIST1H2AC, HIST1H2AG,

HIST1H2AD, A730008H23RIK, GO:0034976~response to CCND1, DERL2, COL4A3BP, GSK3B, AARS, CCDC47, HSPA5, ERO1L, endoplasmic reticulum 0.001881 26 13588 3.712343 0.997973 0.083634 3.367149 EIF2AK3 stress

GO:0031400~negative IBTK, GTPBP4, CDKN2A, GCLC, ATG5, INPP5K, IMPACT, BAX, regulation of protein 0.001982 38 13588 3.104474 0.998549 0.086776 3.545568 FKBP1A, BDKRB2, HHATL modification process

GO:0030035~microspike 0.001993 CDC42, ITGA6, BAIAP2L1, BAIAP2, ITGB4, FGD4 11 13588 5.849752 0.998598 0.086068 3.563806 assembly

EIF6, H2-D1, GM13646, LNX1, LOC100047898, HIST1H2BP,

GTF2E2, HIST1H2BM, HIST1H2BN, H2AFV, GSN, HIST1H2BL, CLP1, GO:0065003~macromolecul 0.002046 GM9531, GPX3, GOPC, HIST1H2BJ, H2AFZ, H2AFX, LSM2, KPNB1, 338 13588 1.554742 0.998826 0.08715 3.658373 ar complex assembly DCTPP1, TAF4A, LOC100045490, MBNL1, H2AFJ, IPO8, MCM2,

FLNA, IPO5, CELF1, EIF2AK3, HI

ANP32B, DBF4, CENPF, CHEK1, BIRC5, ITGB1, APP, CCND1, GO:0051325~interphase 0.002086 51 13588 2.733708 0.998971 0.087637 3.728186 CDC123, CAMK2D, CAMK2B, CDCA5, CABLES1

GO:0009206~purine ATP5D, LOC100045567, ATP10A, ATP1A3, ATP1A1, ATP5G2,

ribonucleoside ATP6V1B2, LOC100046344, ATP13A2, PNP, ATP5G3, ATP6V1D, 0.002104 93 13588 2.191036 0.999029 0.087239 3.759324 triphosphate ATP6V0B, ATP6V1A, ATP2B2, ATP2C2, ATP6V0E2, NME1, ATP8A2,

biosynthetic process ATP5A1, ATP6V0A2

ATP5D, LOC100045567, ATP10A, ATP1A3, ATP1A1, ATP5G2, GO:0009201~ribonucleosi ATP6V1B2, LOC100046344, ATP13A2, PNP, ATP5G3, ATP6V1D, de triphosphate 0.002104 93 13588 2.191036 0.999029 0.087239 3.759324 ATP6V0B, ATP6V1A, ATP2B2, ATP2C2, ATP6V0E2, NME1, ATP8A2, biosynthetic process ATP5A1, ATP6V0A2

GO:0009205~purine ATP5D, FIGNL1, LOC100045567, ATP10A, ATP1A3, ATP1A1,

ribonucleoside 0.002263 ATP5G2, ATP6V1B2, LOC100046344, ATP13A2, PNP, ATP5G3, 101 13588 2.123673 0.999427 0.092387 4.038938

triphosphate metabolic ATP6V1D, ATP6V0B, ATP6V1A, ATP2B2, ATP2C2, ATP6V0E2, NME1, process ATP8A2, ATP5A1, ATP6V0A2

GO:0000079~regulation of -dependent protein 0.002279 CDKN1A, CASP3, GTPBP4, CDKN2A, HEXIM1, CDK5RAP3, BCCIP 16 13588 4.691989 0.999455 0.091856 4.066168

activity

IMPACT, EIF5A, CTCF, APP, EIF4EBP1, CDKN2A, ATG5, DDX25,

GO:0032268~regulation of MLST8, FGF1, IBTK, EGFR, IRAK1, CLN3, GTPBP4, CCDC88A, LYN,

cellular protein 0.002392 MAGOH, LOC100046019, CDK4, EIF4G2, ACVR2A, HMG1L1, CD81, 280 13588 1.608682 0.999626 0.095047 4.264353

metabolic process GM5853, LOC637733, GM7468, EIF2AK3, LOC100048378,

LOC100048076, HMGB1, GCLC, LOC6

ATP5D, FIGNL1, LOC100045567, ATP10A, ATP1A3, ATP1A1, GO:0009199~ribonucleosi ATP5G2, ATP6V1B2, LOC100046344, ATP13A2, PNP, ATP5G3, de triphosphate 0.002544 102 13588 2.102852 0.999773 0.099585 4.529443 ATP6V1D, ATP6V0B, ATP6V1A, ATP2B2, ATP2C2, ATP6V0E2, NME1, metabolic process ATP8A2, ATP5A1, ATP6V0A2

MORF4L1, GNAI2, FST, FKBP1A, CD74, HDGFRP3, GPX1, DOCK2,

IL23A, MCM7, CSE1L, COL4A3BP, LHX9, IMPDH2, ASPM, CHUK, GO:0008283~cell 0.002565 CUL1, HELLS, BMP4, GINS1, MKI67, BRCA2, BAD, HGF, APPL1, 247 13588 1.64993 0.999788 0.099169 4.565055 proliferation APPL2, PURA, HRAS1, ACVR2A, HHEX, AMBN, CCND1, GNB1, GSK3B,

BAX, LRP2, FSHB, LOC10004

GCLC, ERBB3, ADORA2A, CLU, LOC100044385, BNIP3, BDKRB2,

GDNF, CIAPIN1, PNP, CD74, CITED2, MAP3K7, GPX1, CASP3, GO:0043066~negative 0.002646 ATG5, PPP2CB, GLO1, API5, HELLS, CLN3, LOC100045567, AARS, 239 13588 1.660285 0.999838 0.100965 4.706242 regulation of apoptosis ADNP, CENPF, BIRC5, HGF, HRAS1, ATF5, BFAR, DLX1, CDKN1A,

BTG2, GSK3B, BAX, BNIP3L, D

GO:0031399~regulation of LOC100048076, HMGB1, GCLC, GM12568, IMPACT, CTCF, FKBP1A,

protein modification 0.002703 BDKRB2, GM10075, CDKN2A, ATG5, INPP5K, GM5937, MLST8, FGF1, 165 13588 1.819923 0.999866 0.101833 4.804423

process FGD4, HHATL, IBTK, EGFR, MDFI, BMP4, IRAK1, BMP2, GTPBP4, CCDC88A, LYN, FBXO2, LOC100046019, SMAD4, ACVR2A, AKTIP,

HMG1L1, BAX, CD81, GM5

ALDOA, GNPDA1, GNPDA2, IL6ST, GNPNAT1, ALDOC, G6PDX, GPI1,

GO:0005996~monosacchari GALK1, GALM, MAN2B2, ENO2, GALE, ENO1, GPD2, ALDOART1, 0.003079 191 13588 1.740633 0.999961 0.113892 5.455683 de metabolic process GPD1, HKDC1, GALT, BAD, FBP2, FUCA2, FUCA1, CSGALNACT1,

MAN2A1, MPI, MAPK14, GYG, GAA, G6PD2, MDH2

FKBP9, FKBP7, FKBP5, DNAJC10, FKBP1A, CCT3, CD74, DNAJC18,

GO:0006457~protein HSPH1, LOC433064, ERO1L, DNAJA4, HSP90AA1, CWC27, AARS, 0.003162 127 13588 1.942241 0.999971 0.115502 5.599424 folding H2-DMB1, H2-DMB2, CCT5, PPIH, DNAJB9, HSPA4L, GM7879,

DNAJB1, HSPD1, AHSA1

GNAI2, ADORA2A, LPAR2, BCCIP, CD74, APLP2, CDC42, MAP3K5,

GO:0043549~regulation of APP, CASP3, CDKN2A, HEXIM1, MLLT1, CDK5RAP3, MAPKBP1, 0.003333 192 13588 1.731567 0.999983 0.120028 5.893016 kinase activity CEACAM1, FGD4, MDFI, IRAK1, GTPBP4, MAPKSP1, CCDC88A, HGF,

CARD10, CDC25B, ACVR2B, CDKN1A, CD81, IKBKG, DGKZ, CARTPT

ATP5D, ATP10A, ATP1A3, ATP1A1, ATP5G2, ATP6V1B2, ATP5G3, GO:0006754~ATP 0.003334 ATP6V1D, ATP13A2, ATP6V0B, ATP6V1A, ATP2B2, ATP2C2, 82 13588 2.223382 0.999983 0.118765 5.894605 biosynthetic process ATP6V0E2, ATP8A2, ATP5A1, ATP6V0A2

GO:0006986~response to DERL2, HSP90AA1, AARS, CLIC1, EDEM3, MANF, CCND1, 0.003475 54 13588 2.581835 0.99999 0.122157 6.136426 unfolded protein D17H6S56E-3, ATF6B, HSPA4L, ERO1L, CREB3L3, EIF2AK3

FHIT, LOC100044969, BLM, DBF4, CDT1, CCNE2, CCNE1, CDC45,

GO:0006260~DNA MCM7, FEN1, GINS1, CDC6, CCDC88A, MELA, LIG1, BRCA2, MCM2, 0.00355 152 13588 1.834462 0.999992 0.123331 6.265612 replication MCM3, MCM4, MCM5, BRCA1, MCM6, DNA2, TOP3A, CHTF18, CHAF1B,

MED1

ATP5D, FIGNL1, ATP10A, ATP1A3, ATP1A1, ATP5G2, ATP6V1B2, GO:0046034~ATP metabolic 0.003599 ATP5G3, ATP6V1D, ATP13A2, ATP6V0B, ATP6V1A, ATP2B2, 90 13588 2.144909 0.999993 0.12362 6.349116 process ATP2C2, ATP6V0E2, ATP8A2, ATP5A1, ATP6V0A2 GCLC, ERBB3, ADORA2A, CLU, LOC100044385, BNIP3, BDKRB2,

GO:0043069~negative GDNF, CIAPIN1, PNP, CD74, CITED2, MAP3K7, GPX1, CASP3, regulation of programmed 0.003754 ATG5, PPP2CB, GLO1, API5, HELLS, CLN3, LOC100045567, AARS, 244 13588 1.626263 0.999996 0.127282 6.614122

cell death ADNP, CENPF, BIRC5, HGF, HRAS1, ATF5, BFAR, DLX1, CDKN1A,

BTG2, GSK3B, BAX, BNIP3L, D

ALDOA, GNPDA1, IL6ST, ALDOC, G6PDX, GPI1, GALK1, GALM,

GO:0019318~hexose MAN2B2, ENO2, GALE, ENO1, ALDOART1, GPD2, GPD1, HKDC1, 0.003804 169 13588 1.776848 0.999996 0.127568 6.69981 metabolic process GALT, BAD, FBP2, FUCA2, FUCA1, MAN2A1, MPI, MAPK14, GYG,

GAA, G6PD2, MDH2

LIMA1, DERL2, CAPZA3, LOC640611, ARPC5, CAPZB, ATP2B2, APP,

GO:0032535~regulation of CDKN2A, ARPC2, GSN, MAPT, CDA, MLST8, DCLK1, DBNL, CREB1, 0.003849 161 13588 1.798526 0.999997 0.127665 6.77545 cellular component size TMSB10, CDK4, ARPC1B, CORO1A, LOC100048142, CD81, ADRA1B,

BC048355, EMP3, GM9844, APBB1, EPB4.9, ALOX12

GNAI2, ADORA2A, LPAR2, BCCIP, CD74, APLP2, MAP3K5, APP,

GO:0045859~regulation of CASP3, CDKN2A, HEXIM1, MLLT1, CDK5RAP3, MAPKBP1, CEACAM1, 0.003983 186 13588 1.729766 0.999998 0.130508 7.003492 activity FGD4, MDFI, IRAK1, GTPBP4, MAPKSP1, CCDC88A, HGF, CARD10,

CDC25B, CDKN1A, ACVR2B, CD81, IKBKG, DGKZ, CARTPT

GCLC, ERBB3, ADORA2A, CLU, LOC100044385, BNIP3, BDKRB2,

GDNF, CIAPIN1, PNP, CD74, CITED2, MAP3K7, GPX1, CASP3, GO:0060548~negative 0.004018 ATG5, PPP2CB, GLO1, API5, HELLS, CLN3, LOC100045567, AARS, 245 13588 1.619625 0.999998 0.130283 7.062696 regulation of cell death ADNP, CENPF, BIRC5, HGF, HRAS1, ATF5, BFAR, DLX1, CDKN1A,

BTG2, GSK3B, BAX, BNIP3L, D

LIMA1, CAPZA3, CTCF, ARPC5, CAPZB, CDC42, CUL7, ARPC2, GSN,

GO:0033043~regulation of MAPT, MLST8, LTB, FAM33A, DBNL, CCDC88A, MTAP4, TMSB10, 0.004231 154 13588 1.810638 0.999999 0.13541 7.425026 organelle organization HERC2, ARPC1B, CORO1A, LOC100048142, MAD2L1, MTAP1B,

CDK11B, MAPRE1, GM9844, BAT2, EPB4.9 CAV2, ACHE, MSR1, AP1G1, CDC42SE1, BNIP3, GRIN3B, ABCA1,

GDNF, APLP1, CD47, CD9, DOCK2, APP, CLEC4F, ITGAV, GO:0016044~membrane 0.004348 LOC100046998, CHRNA7, CAP1, LBP, COX16, HIP1, CLN3, DBNL, 272 13588 1.577139 0.999999 0.137548 7.621999 organization A4GALT, OPA1, CCDC88A, DENND1A, LMNA, GM9797, ITGA3,

LOC100046344, LDLRAP1, HRAS1, MFN2,

GO:0006275~regulation of 0.004492 DNA2, GTPBP4, CCDC88A, GMNN, BRCA2, ID3, CDT1 18 13588 4.170657 1 0.140421 7.864021 DNA replication

HMGB1, LOC100044969, GM12568, LOC100046019, MCM2, MCM4, GO:0032392~DNA geometric 0.004738 GM10075, MCM6, MCM7, HMG1L1, GM5937, TOP3A, GM5853, 13 13588 4.949791 1 0.146157 8.277443 change LOC637733, GM7468, GM15387, LOC100048378

HMGN1, MORF4L1, KIF22, HMGB2, BLM, MORF4L2, CHEK1, BCCIP,

FANCM, ANKRD17, GM7862, GM2992, H2AFX, FANCG, ERCC3, FANCA,

GO:0006281~DNA repair 0.004782 GM11663, APEX1, ASF1A, FEN1, FANCC, GM9855, EXO1, MSH6, 222 13588 1.642498 1 0.146072 8.352453

DDB1, LIG1, MSH4, GM5521, BRCA2, ATR, GM5806, BRCA1,

GTF2H2, RNF8, DNA2, EEF1E1,

GO:0051248~negative IBTK, CLN3, GTPBP4, GCLC, IMPACT, FKBP1A, BDKRB2, FLNA, regulation of protein 0.005079 78 13588 2.199907 1 0.153012 8.848231 FXR1, EIF4EBP1, CDKN2A, ATG5, INPP5K, BAX, EIF2AK3, HHATL metabolic process

GO:0008064~regulation of DBNL, LIMA1, CAPZA3, TMSB10, ARPC5, CAPZB, ARPC1B, CORO1A, actin polymerization or 0.005473 50 13588 2.573891 1 0.162409 9.502447 LOC100048142, GSN, ARPC2, MLST8, GM9844, EPB4.9 depolymerization

DBNL, CAPZA3, TMSB10, ARPC5, CAPZB, ARPC1B, CORO1A, GO:0032271~regulation of 0.005527 LOC100048142, GSN, ARPC2, MAPT, MAPRE1, MLST8, GM9844, 57 13588 2.445949 1 0.162429 9.592189 protein polymerization EPB4.9

GO:0051338~regulation of GNAI2, ADORA2A, LPAR2, BCCIP, CD74, APLP2, CDC42, MAP3K5, 0.005659 199 13588 1.670658 1 0.164507 9.809468 activity APP, CASP3, CDKN2A, HEXIM1, MLLT1, CDK5RAP3, MAPKBP1, CEACAM1, FGD4, MDFI, IRAK1, GTPBP4, MAPKSP1, CCDC88A, HGF,

CARD10, CDC25B, ACVR2B, CDKN1A, CD81, IKBKG, DGKZ, CARTPT

GO:0015985~energy

coupled proton ATP5D, ATP6V1A, ATP6V0E2, ATP5G2, ATP6V1B2, ATP5A1, 0.005805 37 13588 2.898526 1 0.16693 10.05059 transport, down ATP6V1D, ATP5G3, ATP6V0A2, ATP6V0B electrochemical gradient

GO:0015986~ATP synthesis ATP5D, ATP6V1A, ATP6V0E2, ATP5G2, ATP6V1B2, ATP5A1, 0.005805 37 13588 2.898526 1 0.16693 10.05059 coupled proton transport ATP6V1D, ATP5G3, ATP6V0A2, ATP6V0B

GO:0032269~negative

regulation of cellular IBTK, CLN3, GTPBP4, GCLC, IMPACT, FKBP1A, BDKRB2, FXR1, 0.006026 72 13588 2.23428 1 0.171232 10.41325 protein metabolic EIF4EBP1, CDKN2A, ATG5, INPP5K, BAX, EIF2AK3, HHATL

process

GO:0009112~nucleobase 0.006055 MAPK1, ALDH6A1, DHODH, CAD, AMPD2, AMPD3, GART 19 13588 3.951149 1 0.170519 10.46066 metabolic process

GO:0030832~regulation of DBNL, LIMA1, CAPZA3, TMSB10, ARPC5, CAPZB, ARPC1B, CORO1A, 0.006404 51 13588 2.523423 1 0.177952 11.03203 actin filament length LOC100048142, GSN, ARPC2, MLST8, GM9844, EPB4.9

GO:0006984~ER-nuclear 0.00642 CCND1, DERL2, GSK3B, AARS, CCDC47, HSPA5, ERO1L, EIF2AK3 25 13588 3.431855 1 0.176862 11.05736 signaling pathway

GO:0043523~regulation of CLN3, ERBB3, ADORA2A, AARS, ADNP, BIRC5, GDNF, HRAS1, GPX1, 0.006476 80 13588 2.144909 1 0.176797 11.14867 neuron apoptosis DLX1, EPHA7, CASP9, BAX, DPM1, LTB, BAT2

GO:0006916~anti-apoptos GCLC, CLU, BNIP3, BIRC5, HGF, GDNF, CIAPIN1, CITED2, ATF5, 0.006818 88 13588 2.071787 1 0.183746 11.70424 is BFAR, GSK3B, BNIP3L, GLO1, MAPK8IP1, HELLS, API5, ALOX12

GO:0010564~regulation of FZR1, DBF4, CENPF, BRCA2, BIRC5, HERC2, CDT1, CDC42, 0.006833 73 13588 2.203674 1 0.182619 11.72783 cell cycle process MAD2L1, CUL7, ATF6B, CDK11B, LTB, APBB1, BAT2

GO:0007243~protein GNAI2, GRB2, MKNK2, MKNK1, PINK1, LPAR2, CD74, MAP3K7, 0.006889 236 13588 1.590505 1 0.182501 11.81815 kinase cascade MAP3K5, MAP3K3, ATF6B, MAPKBP1, MAP2K7, CHUK, CDC42EP5, FGD4, MDFI, LOC637082, MAPKSP1, TIFA, MAPK10, HGF, DAPK3,

GSG2, CARD10, MAP4K3, MAPK1, MAP4K4, DOK4, MAPK14, IKBKG,

CD81, MAPK8IP2, CARTPT, MAPK

ABLIM1, LIMS1, ENAH, AGFG1, ADORA2A, CLU, L1CAM, GJC3,

ITGB1, CD9, ATP2B2, CDC42, APP, DOCK2, ANK3, COL4A3BP, GO:0032989~cellular 0.007041 MKKS, ETV1, CAP1, FOXD1, DCLK1, HNRNPAB, COL18A1, CSNK1A1, 351 13588 1.466605 1 0.184674 12.06374 component morphogenesis EGFR, BMP2, KIF3A, MELA, CREB1, DPYSL5, CRB3, LEF1, HGF,

ISL1, DVL1, MFN2, BBS2, EPHA7

EIF6, GM5616, GTPBP4, EXOSC9, EXOSC7, GAR1, EMG1, NHP2L1, GO:0042254~ribosome 0.007329 EXOSC4, BYSL, EXOSC2, ERI1, LOC100044829, FBL, MRTO4, MINA, 112 13588 1.915098 1 0.189978 12.5263 biogenesis DIMT1, DIS3, CDKN2A, BRIX1, IMP4, FTSJ3

GO:0030833~regulation of DBNL, CAPZA3, TMSB10, ARPC5, CAPZB, ARPC1B, CORO1A, actin filament 0.007359 45 13588 2.621556 1 0.189212 12.57506 LOC100048142, GSN, ARPC2, MLST8, GM9844, EPB4.9 polymerization

COPA, AP1G1, LOC100044514, GRIN3B, CLTC, COPB2, CDC42,

IMMP2L, AP2B1, GM10259, KPNB1, COX16, GM10184, RAN, GM9797, GO:0034613~cellular 0.00763 ARNTL, IPO8, TIMM23, FLNA, BCAP31, MFN2, BBS2, COPG2, 299 13588 1.506458 1 0.193978 13.00837 protein localization TIMM8A1, ATG4B, IPO5, ARCN1, COPG, KPNA2, GM10349, SEC23B,

H47, COPZ2, DERL2, GM10273,

GO:0051053~negative

regulation of DNA 0.007979 LOC100046168, MSH6, GTPBP4, BLM, GMNN, NDFIP1, BRCA2, CDT1 20 13588 3.753591 1 0.200382 13.5625

metabolic process

LOC100048076, HMGB1, GM12568, IMPACT, FKBP1A, BDKRB2, GO:0001932~regulation of GM10075, INPP5K, GM5937, MLST8, FGF1, FGD4, IBTK, EGFR, protein amino acid 0.008075 121 13588 1.861285 1 0.201024 13.71473 BMP4, MDFI, IRAK1, BMP2, CCDC88A, LYN, LOC100046019, SMAD4, phosphorylation ACVR2A, HMG1L1, AKTIP, BAX, CD81, GM5853, LOC637733, GM7468, GM15387, LOC100048378

COPA, AP1G1, LOC100044514, GRIN3B, CLTC, COPB2, CDC42,

GO:0070727~cellular IMMP2L, AP2B1, GM10259, KPNB1, COX16, GM10184, RAN, GM9797,

macromolecule 0.008441 ARNTL, IPO8, TIMM23, FLNA, BCAP31, MFN2, BBS2, COPG2, 301 13588 1.496448 1 0.207596 14.29215

localization TIMM8A1, ATG4B, IPO5, ARCN1, COPG, KPNA2, GM10349, SEC23B,

H47, COPZ2, DERL2, GM10273,

GO:0032956~regulation of DBNL, LIMA1, CCDC88A, CAPZA3, TMSB10, ARPC5, CAPZB, ARPC1B, actin cytoskeleton 0.008442 60 13588 2.323652 1 0.206097 14.29401 CORO1A, LOC100048142, ARPC2, GSN, MLST8, GM9844, EPB4.9 organization

GO:0080135~regulation of MDFI, IRAK1, CLN3, LOC100045567, CDC42SE1, PNP, RNF8,

cellular response to 0.008705 MAP3K7, CDKN2A, EEF1E1, LOC100047927, BRE, MAPK8IP2, 75 13588 2.144909 1 0.21027 14.70669

stress FTSJD2, MAPK8IP1, APBB1, FGD4, AXIN1

MDFI, MAPKSP1, GNAI2, GRB2, LPAR2, HGF, MAPK10, CD74, GO:0000165~MAPKKK 0.008856 MAP3K7, MAPK1, MAP3K5, DOK4, CD81, MAPK8IP2, CARTPT, 114 13588 1.881499 1 0.211966 14.94213 cascade MAPK8IP1, MAPKBP1, MAP2K7, CDC42EP5, FGD4

DLC1, ERBB3, LOC100045780, ADRBK1, FKBP1A, EGLN1, CXADR,

ITGB1, CITED2, CASP3, ATG5, GATA6, HEXIM1, COL4A3BP, GATA4, GO:0007507~heart 0.009071 BMP4, BMP2, KIF3A, CENPF, ISL1, MIB1, HHEX, ACVR2B, ID2, 223 13588 1.58704 1 0.214987 15.27714 development ID1, HOPX, GAA, ADRA1B, EPOR, ADAM19, ID3, BMPR1A, ACVR1,

MED1

GO:0051493~regulation of FAM33A, DBNL, LIMA1, CCDC88A, CAPZA3, MTAP4, TMSB10, ARPC5,

cytoskeleton 0.009609 CAPZB, ARPC1B, CORO1A, LOC100048142, ARPC2, GSN, MAPT, 99 13588 1.949917 1 0.224659 16.1115

organization MTAP1B, MAPRE1, MLST8, GM9844, EPB4.9

GO:0032970~regulation of DBNL, LIMA1, CCDC88A, CAPZA3, TMSB10, ARPC5, CAPZB, ARPC1B, actin filament-based 0.009643 61 13588 2.285559 1 0.22377 16.16248 CORO1A, LOC100048142, ARPC2, GSN, MLST8, GM9844, EPB4.9 process GO:0046847~filopodium 0.009954 CDC42, ITGA6, BAIAP2L1, BAIAP2, ITGB4 10 13588 5.362273 1 0.228531 16.64023 assembly

HMGN1, GCLC, BDKRB2, PNP, GPX1, ATP2B2, CASP3, GM7862, APP,

CASP9, AEN, GM2992, ETV1, MKKS, FANCG, ERCC3, EIF2B2, GO:0009628~response to 0.010162 GM11663, LTB, MSH6, DHX9, GUCA1A, MAT2A, CRYAB, 251 13588 1.538182 1 0.231144 16.95903 abiotic stimulus LOC100045567, ATP1A3, BRCA2, DBH, MMP13, RNF8, CDKN1A,

GNB1, HSPB8, BAX, LOC100044391, BRE, A

GO:0050885~neuromuscula

r process controlling 0.011204 CLN3, ATP2B2, IGDCC3, APP, GM2A, HEXB, AARS, GAA, APLP2 34 13588 2.83885 1 0.250015 18.53483

balance

BCKDHA, CLN3, GDAP2, GDAP1, AXL, BRCA2, CLIC1, ASL, FOS, GO:0009991~response to 0.011294 ATG5, ITGA6, MAP1LC3A, D17H6S56E-3, HMOX1, GATA4, ATF6B, 133 13588 1.773985 1 0.250086 18.66966 extracellular stimulus AVPR1A, ARSA, CARTPT, CHRNA7, CP, MEST

GO:0051494~negative

regulation of DBNL, LIMA1, CAPZA3, MTAP4, TMSB10, CAPZB, LOC100048142, 0.011697 48 13588 2.457708 1 0.25611 19.27135 cytoskeleton GSN, MAPT, MTAP1B, MAPRE1, GM9844, EPB4.9

organization

CCDC88A, KIF3A, BAIAP2L1, BAIAP2, ITGB4, CAPZB, BBS2, GO:0030031~cell 0.011721 CDC42, NCK2, ITGA6, IFT172, MKKS, LOC100044475, GM16517, 70 13588 2.144909 1 0.254892 19.30698 projection assembly FGD4

HACL1, ACOX1, ECH1, HADHA, CD74, FAR1, ELOVL5, ELOVL4,

GO:0006631~fatty acid ALOX5AP, ELOVL7, ELOVL6, HADH, ACSL4, ACAA1A, ACAA1B, 0.011826 184 13588 1.631996 1 0.255205 19.46292 metabolic process ACAA2, FA2H, ADIPOR1, LYPLA2, CBR4, CRAT, ACADL, BRCA1,

ACADVL, MAPK14, H2-KE6, AACS, ALOX12

GO:0002495~antigen 0.0127 H2-OA, H2-EB1, H2-DMB1, IFI30, CD74, H2-DMB2 16 13588 4.021705 1 0.269625 20.74898 processing and presentation of peptide antigen via MHC class II

GO:0019886~antigen

processing and

presentation of 0.0127 H2-OA, H2-EB1, H2-DMB1, IFI30, CD74, H2-DMB2 16 13588 4.021705 1 0.269625 20.74898

exogenous peptide antigen via MHC class II

KIF23, KIF22, HAUS3, HAUS2, DNAHC11, KLC3, DYNLT1-PS1,

HOOK2, KIF2C, APP, LOC631653, GM3417, MAPT, DYNC1H1, KIF2A, GO:0007017~- 0.012733 KIF11, KIF3A, KIF5B, CKAP5, KIF18A, BIRC5, BICD2, TCTE3, 211 13588 1.575644 1 0.268524 20.7975 based process BRCA1, DCTN2, KIF1C, BBS2, KIF1B, LYST, MTAP1B, DYNLT1E,

GM3448, DYNLT1D, DYNLT1F,

GO:0008629~induction of

apoptosis by 0.013368 MSH6, GPX1, CASP3, AEN, HMOX1, BAX, DIABLO, BRCA2, BRCA1 35 13588 2.75774 1 0.27816 21.7179

intracellular signals

GO:0043242~negative DBNL, LIMA1, CAPZA3, GSN, MAPT, MTAP4, MTAP1B, CAPZB, regulation of protein 0.013368 35 13588 2.75774 1 0.27816 21.7179 EPB4.9 complex disassembly

GO:0006338~chromatin MORF4L1, BPTF, HJURP, MTA2, A730008H23RIK, BNIP3, INO80, 0.013368 35 13588 2.75774 1 0.27816 21.7179 remodeling CHD1, ACTL6A, HELLS

GO:0034220~ion ATP5D, ATP6V1A, ATP6V0E2, ATP5G2, ATP6V1B2, ATP5A1, 0.013664 42 13588 2.553463 1 0.281652 22.1449 transmembrane transport ATP6V1D, ATP5G3, ATP6V0A2, ATP6V0B

GO:0007090~regulation of

S phase of mitotic cell 0.014503 DBF4, ATF6B, BRCA2, APBB1, CDT1 11 13588 4.874794 1 0.294401 23.34056

cycle

GO:0006268~DNA unwinding 0.014503 MCM7, LOC100044969, TOP3A, MCM2, MCM4, MCM6 11 13588 4.874794 1 0.294401 23.34056 during replication

GO:0042770~DNA damage CDK1, MSH6, CCND1, AEN, HMOX1, MAPK14, BRE, BRCA2, H2AFX, response, signal 0.014857 57 13588 2.257799 1 0.298637 23.84096 CHEK1, ATR, BRCA1 transduction

GO:0007492~endoderm 0.01502 ANKRD17, HHEX, HDAC1, LHX1, GATA6, EXT1, ANGPT2, BMPR1A 29 13588 2.958495 1 0.299583 24.0693 development

ACVRL1, GRB2, COPS3, EGLN1, GM8416, MED21, ITGB1, CITED2,

INPP5K, GATA6, COL4A3BP, GATA4, GATAD2A, GM5593, APBA2, GO:0001701~in utero 0.015212 AMD1, AMD2, ENO1, GINS1, EGFR, MDFI, KIF3A, AMD-PS3, BRCA2, 267 13588 1.486173 1 0.301002 24.33813 embryonic development LEF1, MBNL1, CCNB1, HBA-A1, MFN2, HBA-A2, MAPK1, MIB1,

MAN2A1, ENDOG, GRN, HOPX,

LOC100046932, HMGB2, TESC, FST, TAF4A, MSH4, BRCA2, CDH6, GO:0008406~gonad 0.015402 IMMP2L, ACVR2A, BAX, LOC100047138, BIK, FANCG, EIF2B2, 88 13588 1.949917 1 0.302369 24.60344 development FSHB, LHX9, FANCA

GO:0043524~negative CLN3, DLX1, ERBB3, ADORA2A, BAX, AARS, ADNP, DPM1, BIRC5, regulation of neuron 0.015512 50 13588 2.3594 1 0.3024 24.75587 GDNF, HRAS1 apoptosis

DBNL, CAPZA3, TMSB10, ARPC5, CAPZB, ARPC1B, CORO1A, GO:0043254~regulation of 0.015813 LOC100048142, GSN, ARPC2, MAPT, MAPRE1, MLST8, GM9844, 65 13588 2.144909 1 0.305541 25.17444 protein complex assembly EPB4.9

GO:0043244~regulation of DBNL, LIMA1, CAPZA3, GSN, MAPT, MTAP4, MTAP1B, EIF5A, protein complex 0.015893 43 13588 2.494081 1 0.30507 25.28448 CAPZB, EPB4.9 disassembly

GO:0002478~antigen

processing and 0.01633 H2-OA, H2-EB1, H2-DMB1, IFI30, CD74, H2-DMB2, B2M 23 13588 3.263992 1 0.31028 25.88562

presentation of exogenous peptide

antigen

GO:0009156~ribonucleosi

de monophosphate 0.016639 DHODH, GM5081, AMPD2, AMPD3, IMPDH2, GART, PRPS1 17 13588 3.785134 1 0.313387 26.30823

biosynthetic process

ACVRL1, FOXM1, TNFSF13, CDH2, TNFSF12, GPI1, LOC100044363,

CITED2, MAP3K7, ANGPTL6, GPX1, WARS, ATG5, CUL7, HMOX1, GO:0048514~blood vessel 0.016787 ITGAV, FGF1, ANGPT2, COL18A1, BMP4, EGFL7, DBH, ANXA2, 198 13588 1.570767 1 0.313949 26.51031 morphogenesis NUS1, MEOX2, MAPK14, BAX, DLL4, ADRA1B, AMOT,

TNFSF12-TNFSF13, ACVR1

DLC1, LOC630896, ENAH, ACVRL1, COPS3, LMO4, DLK1, MED21,

GO:0009792~embryonic GM8416, CITED2, GM8096, MAP3K7, GM13337, FXN, GATA6,

development ending in 0.017145 COL4A3BP, GATA4, GM5593, EGFR, LEF1, MBNL1, MFN2, ACVR2A, 425 13588 1.362648 1 0.317716 26.99461

birth or egg hatching MAN2A1, MIB1, MAPK1, GRN, CDK11B, ACVR1, MED1, GM7669,

LIMS1, GRB2, EGLN1, ABI1, ITGB1,

GO:0033674~positive MDFI, IRAK1, CCDC88A, MAPKSP1, GNAI2, ADORA2A, LPAR2, HGF,

regulation of kinase 0.017249 CD74, CARD10, CDC25B, CDC42, MAP3K5, ACVR2B, CD81, IKBKG, 130 13588 1.732427 1 0.317573 27.13596

activity CARTPT, DGKZ, MAPKBP1, CEACAM1, FGD4

ADORA2A, LOC100044207, BNIP3, ITM2B, CTNNBL1, GPX1, CASP3,

CDKN2A, CASP9, CASP8AP2, HMOX1, AEN, DIABLO, DDX20, ERCC3, GO:0010942~positive 0.017778 CASP1, LTB, COL18A1, BMP4, MSH6, CYCS, BRCA2, BAD, DAPK3, 252 13588 1.48952 1 0.323829 27.84598 regulation of cell death BRCA1, EPHA7, CDKN1A, ENDOG, EEF1E1, BAX, BNIP3L, BIK, ID3,

BMP7, APBB1, BAT2

GO:0006091~generation of ALDOA, ATP5D, GNPDA1, ENOX2, IL6ST, ALDOC, ATP5G2,

precursor metabolites 0.017823 ATP6V1B2, GPI1, ATP5G3, ATP6V0B, CYB561D2, IDH3G, FXN, 261 13588 1.479248 1 0.322755 27.90575

and energy ENO2, IDH2, ETFDH, ERO1L, ETFB, ENO1, ALDOART1, ACO2, FA2H, HKDC1, CYCS, CYB5B, CYB561, ATP6V1D, FRRS1, ATP6V1A,

ATP6V0E2, GYG, GAA, ATP5A1, MDH2, AT

LOC100048076, BMP4, ARFRP1, SMAD4, LEF1, ACVR2A, FAM48A, GO:0007369~gastrulation 0.018304 74 13588 2.028968 1 0.328153 28.54562 ACVR2B, LHX1, GATA4, AMOT, EXT1, BMP7, BMPR1A, ACVR1

MDFI, LOC100048076, IRAK1, HMGB2, GTPBP4, MTDH, BLM, SMAD4, GO:0051098~regulation of 0.018681 ATR, FLNA, MAPK1, AKTIP, HMOX1, MAPK3, CALM3, IKBKB, 90 13588 1.906586 1 0.331921 29.04276 binding EIF2AK3, CALM1

GO:0030509~BMP signaling 0.0201 BMP4, ACVR2A, BMP2, ID1, FST, BMP7, BMPR1A 24 13588 3.127993 1 0.350474 30.88731 pathway

GO:0006298~mismatch 0.020176 EXO1, ANKRD17, MSH6, MSH4, TDG, GM5806, GM9855 12 13588 4.468561 1 0.349744 30.98507 repair

GO:0032508~DNA duplex 0.020176 MCM7, LOC100044969, TOP3A, MCM2, MCM4, MCM6 12 13588 4.468561 1 0.349744 30.98507 unwinding

GO:0051085~chaperone mediated protein folding 0.020176 HSPH1, H2-DMB1, DNAJB1, CD74, H2-DMB2 12 13588 4.468561 1 0.349744 30.98507

requiring

GO:0033261~regulation of 0.020176 DBF4, ATF6B, BRCA2, APBB1, CDT1 12 13588 4.468561 1 0.349744 30.98507

GO:0000075~cell cycle CDK1, CCND1, MAD2L1, MAPK14, BRE, H2AFX, BIRC5, CHEK1, ATR, 0.02018 52 13588 2.268654 1 0.348008 30.98959 checkpoint LOC100045958, PURA, CDT1

GO:0015992~proton ATP5D, ATP6V1A, ATP6V0E2, ATP5G2, ATP6V1B2, ATP6V1G1, 0.02018 52 13588 2.268654 1 0.348008 30.98959 transport ATP5A1, ATP6V1D, ATP5G3, ATP6V0A2, ATP6V0B

ABLIM1, LIMS1, ENAH, ADORA2A, CLU, L1CAM, GJC3, ATP2B2,

GO:0000902~cell CDC42, APP, DOCK2, ANK3, COL4A3BP, ETV1, MKKS, CAP1, FOXD1, 0.020265 309 13588 1.422998 1 0.347423 31.09854 morphogenesis DCLK1, HNRNPAB, COL18A1, CSNK1A1, EGFR, BMP2, KIF3A, CREB1,

DPYSL5, CRB3, LEF1, HGF, ISL1, DVL1, BBS2, EPHA7, ID1, MAPK14, IFT172, EPB4.2,

GO:0045860~positive MDFI, IRAK1, CCDC88A, MAPKSP1, GNAI2, ADORA2A, LPAR2, HGF,

regulation of protein 0.020719 CD74, CARD10, CDC25B, MAP3K5, ACVR2B, CD81, IKBKG, CARTPT, 124 13588 1.729766 1 0.351921 31.67699

kinase activity DGKZ, MAPKBP1, CEACAM1, FGD4

LOC630896, LIMA1, ENAH, L1CAM, GDNF, GM8096, CDC42, ATP2B2,

GM13337, APP, ANK3, MKKS, CCDC88A, BAIAP2, LPIN1, BBS2, GO:0030030~cell 0.021111 NCK2, MTAP1B, IGSF9, GAP43, ABLIM1, GM7669, ADORA2A, CLU, 319 13588 1.412009 1 0.355504 32.1736 projection organization B9D2, ITGB4, KLC3, CAPZB, GM8341, ETV1, LOC100044475,

FOXD1, DCLK1, FGD4, GM9252,

GO:0031668~cellular FOS, CLN3, ATG5, MAP1LC3A, ITGA6, HMOX1, ATF6B, AVPR1A, response to 0.021132 45 13588 2.383232 1 0.354016 32.19914 AXL, CARTPT extracellular stimulus

GO:0031397~negative

regulation of protein 0.021202 GTPBP4, CDKN2A, GCLC, ATG5 7 13588 6.128312 1 0.353221 32.28807

ubiquitination

GO:0045931~positive HMGB1, GM12568, LOC100046019, BRCA2, BIRC5, GM10075, APP,

regulation of mitotic 0.021202 HMG1L1, GM5937, GM5853, LOC637733, GM7468, GM15387, 7 13588 6.128312 1 0.353221 32.28807

cell cycle LOC100048378

GO:0000070~mitotic

sister chromatid 0.021311 MAD2L1, ATF6B, KIF18A, AKAP8, CDCA5, BUB3 18 13588 3.574849 1 0.352943 32.42472

segregation

GO:0044275~cellular ALDOA, ALDOART1, GPD1, GNPDA1, ALDOC, HKDC1, GAA, ENO2, carbohydrate catabolic 0.021383 60 13588 2.144909 1 0.352179 32.51494 BAD, GPI1, MDH2, ENO1 process

GO:0050863~regulation of HSP90AA1, BLM, ADORA2A, LOC100045567, IL4RA, NDFIP1, 0.021779 108 13588 1.787424 1 0.355697 33.00985 T cell activation CENPF, BAD, PNP, CD74, LOC100046168, CORO1A, CASP3, CDKN2A, H2-OA, HLX, CD274, HSPD1, CSK, LAG3

GO:0006818~hydrogen ATP5D, ATP6V1A, ATP6V0E2, ATP5G2, ATP6V1B2, ATP6V1G1, 0.022865 53 13588 2.225849 1 0.368071 34.34996 transport ATP5A1, ATP6V1D, ATP5G3, ATP6V0A2, ATP6V0B

GO:0008585~female gonad IMMP2L, LOC100046932, BAX, MSH4, FST, TAF4A, BRCA2, FANCG, 0.022865 53 13588 2.225849 1 0.368071 34.34996 development EIF2B2, FANCA, LHX9, CDH6

HMGN1, PNP, GPX1, APP, GM7862, CASP3, CASP9, AEN, GM2992,

GO:0009314~response to FANCG, ERCC3, GM11663, GUCA1A, MSH6, MAT2A, LOC100045567, 0.024128 143 13588 1.64993 1 0.382301 35.87757 radiation ATP1A3, BRCA2, DBH, RNF8, CDKN1A, GNB1, BAX, LOC100044391,

BRE, ADRA1B, FTSJD2, APBB1

KIF23, KIF22, KIF3A, KIF11, KIF5B, KIF18A, DNAHC11, KLC3, GO:0007018~microtubule- 0.024161 BICD2, TCTE3, KIF1C, KIF2C, APP, KIF1B, LOC631653, GM3417, 101 13588 1.805122 1 0.380938 35.91706 based movement GM3448, DYNC1H1, KIF20A, KIF2A

COPZ2, COPA, DERL2, AP1G1, GM10273, GM10333, COPZ1, CACNB1,

GM10233, LOC100044514, CLTC, GM10171, CD74, COPB2, IMMP2L, GO:0006886~intracellula 0.024185 AP2B1, CSE1L, FOLR1, AP3M1, GM10259, KPNB1, COX16, AP2M1, 276 13588 1.437711 1 0.379479 35.94595 r protein transport LOC100048726, RAN, GM10184, GM9797, ARNTL, IPO8, AP4S1,

TIMM23, BCAP31, MFN2,

GO:0007252~I-kappaB 0.024409 MAP3K7, IKBKB, CHUK 3 13588 10.72455 1 0.380496 36.21296 phosphorylation

GO:0045639~positive HMGB1, TESC, GM12568, LOC100046019, JAG1, GM10075, ID2,

regulation of myeloid 0.02442 HMG1L1, ETS1, GM5937, MAPK14, LOC100047138, GM5853, 25 13588 3.002873 1 0.378893 36.22589

cell differentiation LOC637733, GM7468, ACIN1, GM15387, LOC100048378

GO:0051952~regulation of 0.02442 ADORA2A, CARTPT, PINK1, CHRNA7, GDNF, LTB, BAT2 25 13588 3.002873 1 0.378893 36.22589 amine transport

GO:0009890~negative LOC100044341, HR, CBX4, CBX1, CBX8, CITED2, CBX5, CDT1, 0.024796 434 13588 1.334391 1 0.381751 36.67155 regulation of EIF4EBP1, INSIG2, ATF6B, DDX20, BHLHE41, LAG3, EGR1, CTBP1, biosynthetic process GTPBP4, MTA2, LEF1, PURA, COBRA1, HHEX, BPTF, CUX1,

EIF2AK3, MTDH, GCLC, HAT1, HEXIM1, GATAD2A, BHLHE40,

DNMT3B, HELLS, HNRNPAB, HHATL, MDF

GO:0051347~positive MDFI, IRAK1, CCDC88A, MAPKSP1, GNAI2, ADORA2A, LPAR2, HGF,

regulation of 0.025065 CD74, CARD10, CDC25B, CDC42, MAP3K5, ACVR2B, CD81, IKBKG, 135 13588 1.668263 1 0.383276 36.98839

transferase activity CARTPT, DGKZ, MAPKBP1, CEACAM1, FGD4

ACVRL1, FOXM1, TNFSF13, CDH2, TNFSF12, GPI1, LOC100044363,

CITED2, MAP3K7, ANGPTL6, GPX1, WARS, ATG5, CUL7, ITGAV, GO:0001944~vasculature 0.025706 HMOX1, GATAD2A, FGF1, ANGPT2, COL18A1, BMP4, EGFL7, DBH, 250 13588 1.458538 1 0.389212 37.73782 development ANXA2, MAPK1, MIB1, LAMA4, NUS1, MEOX2, ID1, DLL4, MAPK14,

BAX, ADRA1B, AMOT, TNFSF

ADORA2A, LOC100044207, BNIP3, ITM2B, CTNNBL1, GPX1, CASP3,

GO:0043068~positive CDKN2A, CASP9, CASP8AP2, HMOX1, AEN, DIABLO, DDX20, ERCC3, regulation of programmed 0.025706 CASP1, LTB, COL18A1, MSH6, CYCS, BRCA2, BAD, DAPK3, BRCA1, 250 13588 1.458538 1 0.389212 37.73782

cell death EPHA7, CDKN1A, ENDOG, EEF1E1, BAX, BNIP3L, BIK, ID3, BMP7,

APBB1, BAT2

BLM, ADORA2A, IL4RA, TNFSF13, TNFSF12, PNP, CD74, CASP3,

GO:0051249~regulation of CDKN2A, HLX, CSK, LAG3, HSP90AA1, LOC100045567, NDFIP1, 0.025859 144 13588 1.638472 1 0.389302 37.91604 lymphocyte activation CENPF, BAD, LOC100046168, CDKN1A, CORO1A, H2-OA, LYST,

CD274, CD81, HSPD1, TNFSF12-TNFSF13

CAV2, ACHE, MSR1, AP1G1, CDC42SE1, ABCA1, APLP1, CD47, APP,

CLEC4F, ITGAV, CHRNA7, LBP, CAP1, COX16, HIP1, DBNL, CLN3, GO:0006897~endocytosis 0.026563 188 13588 1.540227 1 0.395813 38.72673 DENND1A, LDLRAP1, LOC100046344, HRAS1, NME1, LRP2, BIN1,

DNM1, CLCN5, DNM2

GO:0010324~membrane CAV2, ACHE, MSR1, AP1G1, CDC42SE1, ABCA1, APLP1, CD47, APP, 0.026563 188 13588 1.540227 1 0.395813 38.72673 invagination CLEC4F, ITGAV, CHRNA7, LBP, CAP1, COX16, HIP1, DBNL, CLN3, DENND1A, LDLRAP1, LOC100046344, HRAS1, NME1, LRP2, BIN1,

DNM1, CLCN5, DNM2

GO:0002504~antigen

processing and presentation of peptide 0.02676 H2-OA, H2-EB1, H2-DMB1, IFI30, CD74, H2-DMB2 19 13588 3.386699 1 0.396367 38.95172

or polysaccharide antigen via MHC class II

GO:0000819~sister 0.02676 MAD2L1, ATF6B, KIF18A, AKAP8, CDCA5, BUB3 19 13588 3.386699 1 0.396367 38.95172 chromatid segregation

GO:0009161~ribonucleosi

de monophosphate 0.02676 DHODH, GM5081, AMPD2, AMPD3, IMPDH2, GART, PRPS1 19 13588 3.386699 1 0.396367 38.95172

metabolic process

GO:0045793~positive 0.02676 DERL2, LOC640611, MAPT, CD81, BC048355, CDK4, ALOX12 19 13588 3.386699 1 0.396367 38.95172 regulation of cell size

GO:0010639~negative DBNL, LIMA1, CAPZA3, MTAP4, TMSB10, CAPZB, MAD2L1, regulation of organelle 0.026768 62 13588 2.075719 1 0.394752 38.96164 LOC100048142, GSN, MAPT, MTAP1B, MAPRE1, GM9844, EPB4.9 organization

GO:0007178~transmembran

e protein LOC100048076, BMP4, BMP2, ACVRL1, FST, SMAD4, GDNF, MAP3K7, 0.02735 78 13588 1.924919 1 0.399689 39.62155 serine/threonine kinase ACVR2A, ACVR2B, ID1, BAMBI, BMP7, BMPR1A, ACVR1

signaling pathway

GCLC, ADORA2A, G6PDX, ADH5, ATP1A1, AGTRAP, GPX1, ACE, GO:0008015~blood 0.027733 ATG5, F5, HMOX1, AVPR1A, ADRA1B, CAMK2D, CARTPT, GUCY1A3, 111 13588 1.739116 1 0.402308 40.05265 circulation CHRNA7, LOC100048559

GO:0003013~circulatory GCLC, ADORA2A, G6PDX, ADH5, ATP1A1, AGTRAP, GPX1, ACE, 0.027733 111 13588 1.739116 1 0.402308 40.05265 system process ATG5, F5, HMOX1, AVPR1A, ADRA1B, CAMK2D, CARTPT, GUCY1A3, CHRNA7, LOC100048559

ACOX1, CAPZA3, HEXB, STYX, FST, HNRPLL, CITED2, IMMP2L,

ATP2B2, DDX25, GPX4, GOPC, MKKS, H2AFX, CHRNA7, FANCG, GO:0032504~multicellula 0.027752 EIF2B2, CHUK, FANCC, LIMK2, MAGOH, TAF4A, HERC2, HMGA1, 409 13588 1.337291 1 0.400822 40.07428 r organism reproduction LOC100046344, BCAP31, ACVR2A, BBS2, CCND1, NME1, CELF1,

EIF2AK3, MED1, ACVR1, LOC1000469

ACOX1, CAPZA3, HEXB, STYX, FST, HNRPLL, CITED2, IMMP2L,

GO:0048609~reproductive ATP2B2, DDX25, GPX4, GOPC, MKKS, H2AFX, CHRNA7, FANCG,

process in a 0.027752 EIF2B2, CHUK, FANCC, LIMK2, MAGOH, TAF4A, HERC2, HMGA1, 409 13588 1.337291 1 0.400822 40.07428

multicellular organism LOC100046344, BCAP31, ACVR2A, BBS2, CCND1, NME1, CELF1,

EIF2AK3, MED1, ACVR1, LOC1000469

BLM, ADORA2A, IL4RA, TNFSF13, TNFSF12, PNP, CD74, CASP3,

GO:0002694~regulation of CDKN2A, HLX, HMOX1, CSK, LAG3, HSP90AA1, LOC100045567, 0.028328 154 13588 1.601718 1 0.405546 40.71717 leukocyte activation NDFIP1, CENPF, BAD, LOC100046168, CDKN1A, CORO1A, H2-OA,

LYST, CD274, CD81, HSPD1, TNFSF12-TNFSF13

GO:0001702~gastrulation LOC100048076, ACVR2A, ACVR2B, LHX1, GATA4, SMAD4, AMOT, 0.029319 26 13588 2.887378 1 0.414699 41.80718 with mouth forming second ACVR1

GO:0031570~DNA integrity 0.029702 CDK1, CCND1, MAPK14, BRE, H2AFX, CHEK1, ATR, CDT1 33 13588 2.59989 1 0.417126 42.22353 checkpoint

ACVRL1, FOXM1, TNFSF13, CDH2, TNFSF12, GPI1, LOC100044363,

CITED2, MAP3K7, ANGPTL6, GPX1, WARS, ATG5, CUL7, ITGAV, GO:0001568~blood vessel 0.03003 HMOX1, GATAD2A, FGF1, ANGPT2, COL18A1, BMP4, EGFL7, DBH, 244 13588 1.450451 1 0.418933 42.57802 development ANXA2, MAPK1, MIB1, LAMA4, NUS1, MEOX2, MAPK14, BAX, DLL4,

ADRA1B, AMOT, TNFSF12-TN

GO:0043009~chordate DLC1, LOC630896, ENAH, ACVRL1, COPS3, LMO4, DLK1, MED21, 0.03074 421 13588 1.324647 1 0.424746 43.33824 embryonic development GM8416, CITED2, GM8096, MAP3K7, GM13337, GATA6, COL4A3BP, GATA4, GM5593, EGFR, LEF1, MBNL1, MFN2, ACVR2A, MIB1,

MAPK1, MAN2A1, GRN, CDK11B, MED1, ACVR1, GM7669, LIMS1,

GRB2, EGLN1, ABI1, ITGB1, INPP

GO:0006516~glycoprotein 0.031606 CLN3, FBXO2, EDEM3, MANBA 8 13588 5.362273 1 0.432055 44.25226 catabolic process

GO:0006206~pyrimidine 0.031606 MAPK1, ALDH6A1, DHODH, CAD 8 13588 5.362273 1 0.432055 44.25226 base metabolic process

GO:0051303~establishmen

t of chromosome 0.031606 KIF18A, CENPF, BIRC5, CDCA5 8 13588 5.362273 1 0.432055 44.25226

localization

GO:0043064~flagellum 0.031606 BBS2, MKKS, KLC3, GM16517 8 13588 5.362273 1 0.432055 44.25226 organization

GO:0050000~chromosome 0.031606 KIF18A, CENPF, BIRC5, CDCA5 8 13588 5.362273 1 0.432055 44.25226 localization

GO:0006596~polyamine ODC1, GM9115, AMD-PS3, GM7993, GM6742, AZIN1, AMD1, 0.031606 8 13588 5.362273 1 0.432055 44.25226 biosynthetic process GM14680, SMS, AMD2

GO:0006983~ER overload 0.031606 GSK3B, CCDC47, HSPA5, EIF2AK3 8 13588 5.362273 1 0.432055 44.25226 response

BLM, ADORA2A, IL4RA, TNFSF13, TNFSF12, PNP, CD74, CASP3,

GO:0050865~regulation of CDKN2A, HLX, HMOX1, CSK, LAG3, HSP90AA1, LOC100045567, 0.032206 156 13588 1.581183 1 0.436497 44.87743 cell activation NDFIP1, CENPF, BAD, LOC100046168, CDKN1A, CORO1A, H2-OA,

LYST, CD274, CD81, HSPD1, TNFSF12-TNFSF13

GO:0006119~oxidative ATP5D, ATP6V1A, ATP6V0E2, FXN, ATP5G2, ATP6V1B2, ATP5A1, 0.032456 56 13588 2.106607 1 0.437322 45.13576 phosphorylation ATP6V1D, ATP5G3, ATP6V0A2, ATP6V0B

GO:0009311~oligosacchar 0.03302 MAN2A1, GLA, GM2A, MPDU1, HEXB, MOGS 20 13588 3.217364 1 0.441293 45.71471 ide metabolic process GO:0046660~female sex LOC100046932, TAF4A, FST, MSH4, BRCA2, CDH6, IMMP2L, BAX, 0.033069 64 13588 2.010852 1 0.440079 45.76497 differentiation FANCG, EIF2B2, LHX9, FANCA, MED1

GO:0010608~posttranscri GTPBP4, LOC640611, IMPACT, MAGOH, MKNK2, ELAVL1, IFI30,

ptional regulation of 0.033743 MKNK1, EIF5A, IGF2BP3, CDK4, FLNA, FXR1, APLP1, EIF4G2, 148 13588 1.594189 1 0.445064 46.44876

expression MOV10, EIF4EBP1, APP, CDKN2A, CLP1, DDX25, APBB1, EIF2AK3

GM5616, GM11847, DGCR14, HNRPLL, AUH, APP, SRRM2, CLP1,

LOC100044383, LOC433064, GPX4, BAT1A, LSM5, MAGOHB, DBR1, GO:0016071~mRNA 0.034395 LSM3, LSM2, DDX20, LUC7L3, CSDC2, LOC100046744, EFTUD2, 302 13588 1.384958 1 0.449737 47.10167 metabolic process MAGOH, CDC5L, MBNL1, HNRPDL, DDX39, GM8186, CELF1, ESRP2,

SNRPG, NHP2L1, PNPT1, APLP1

HMGB1, GM12568, LOC100046019, CENPF, BRCA2, BIRC5, GO:0045787~positive 0.034498 GM10075, CITED2, APP, HMG1L1, GM5937, GM5853, LOC637733, 34 13588 2.523423 1 0.449038 47.20417 regulation of cell cycle GM7468, GM15387, LTB, BAT2, LOC100048378

GO:0022618~ribonucleopr 0.034498 EIF6, EIF3A, CLP1, GEMIN8, CELF1, LSM2, MBNL1, GEMIN6 34 13588 2.523423 1 0.449038 47.20417 otein complex assembly

GO:0031333~negative DBNL, LOC100048142, CAPZA3, GSN, TMSB10, MAPRE1, GM9844, regulation of protein 0.03482 27 13588 2.780438 1 0.450462 47.52416 CAPZB, EPB4.9 complex assembly

GO:0032272~negative DBNL, LOC100048142, CAPZA3, GSN, TMSB10, MAPRE1, GM9844, regulation of protein 0.03482 27 13588 2.780438 1 0.450462 47.52416 CAPZB, EPB4.9 polymerization

GO:0006458~'de novo' 0.035129 HSPH1, H2-DMB1, DNAJB1, CD74, H2-DMB2 14 13588 3.830195 1 0.451738 47.82884 protein folding

GO:0051084~'de novo'

posttranslational 0.035129 HSPH1, H2-DMB1, DNAJB1, CD74, H2-DMB2 14 13588 3.830195 1 0.451738 47.82884

protein folding GO:0046545~development IMMP2L, LOC100046932, BAX, MSH4, FST, TAF4A, BRCA2, FANCG, of primary female sexual 0.036201 57 13588 2.069649 1 0.460186 48.87297 EIF2B2, FANCA, LHX9, CDH6 characteristics

GM7669, LOC630896, AZIN1, ASL, GM8096, GOT2, GM13337,

GO:0009309~amine GM8341, GATA3, GM7993, GM6742, CHRNA7, ENOPH1, AMD1, 0.036477 73 13588 1.909851 1 0.461078 49.13885 biosynthetic process GM14680, AMD2, ODC1, GM9115, GM9252, AMD-PS3, MAT2A,

GM6756, GM7901, DBH, GM9347, DHFR, PHGDH, GM9210, SMS

ADORA2A, LOC100044207, BNIP3, ITM2B, CTNNBL1, GPX1, CASP3,

CDKN2A, CASP9, CASP8AP2, HMOX1, AEN, DIABLO, DDX20, CASP1, GO:0043065~positive 0.036572 ERCC3, LTB, COL18A1, MSH6, CYCS, BRCA2, BAD, DAPK3, BRCA1, 248 13588 1.427057 1 0.460285 49.23027 regulation of apoptosis EPHA7, ENDOG, EEF1E1, BAX, BNIP3L, BIK, ID3, BMP7, APBB1,

BAT2

GO:0046164~alcohol ALDOA, ALDOART1, GPD1, GNPDA1, ALDOC, HKDC1, ENO2, BAD, 0.036584 65 13588 1.979916 1 0.458734 49.24222 catabolic process DBH, GPI1, MDH2, ENO1

ADORA2A, LOC100044207, BNIP3, ITM2B, CTNNBL1, GPX1, CASP3, GO:0006917~induction of 0.036846 CASP8AP2, CASP9, AEN, HMOX1, DIABLO, DDX20, ERCC3, CASP1, 167 13588 1.541252 1 0.459493 49.49279 apoptosis LTB, MSH6, BRCA2, BAD, DAPK3, BRCA1, BAX, BNIP3L, BIK, BAT2

ADORA2A, LOC100044207, BNIP3, ITM2B, CTNNBL1, GPX1, CASP3, GO:0012502~induction of 0.036846 CASP8AP2, CASP9, AEN, HMOX1, DIABLO, DDX20, ERCC3, CASP1, 167 13588 1.541252 1 0.459493 49.49279 programmed cell death LTB, MSH6, BRCA2, BAD, DAPK3, BRCA1, BAX, BNIP3L, BIK, BAT2

HMGN1, MSH6, GUCA1A, MAT2A, ATP1A3, BRCA2, DBH, CDKN1A, GO:0009416~response to 0.037282 CASP3, APP, GM7862, CASP9, GNB1, BAX, LOC100044391, ADRA1B, 98 13588 1.750946 1 0.46183 49.90693 light stimulus GM2992, ERCC3, APBB1, GM11663

BCKDHA, CLN3, GDAP2, GDAP1, BRCA2, CLIC1, ASL, ATG5, GO:0031667~response to 0.037462 MAP1LC3A, D17H6S56E-3, HMOX1, GATA4, ATF6B, ARSA, CARTPT, 115 13588 1.678625 1 0.46182 50.077 nutrient levels CHRNA7, CP, MEST GO:0050868~negative LOC100046168, CASP3, CDKN2A, ADORA2A, HLX, CD274, IL4RA, regulation of T cell 0.037665 42 13588 2.298117 1 0.462015 50.26783 NDFIP1, LAG3, CD74 activation

GM7669, LOC630896, ASL, CD74, GM8096, FAR1, GOT2, GM13337,

GO:0046394~carboxylic ELOVL5, ELOVL4, GM8341, ALOX5AP, LIAS, ELOVL7, ELOVL6,

acid biosynthetic 0.037702 ENOPH1, LIPT2, GM9252, MAT2A, FA2H, GM6756, CBR4, GM7901, 141 13588 1.597273 1 0.460725 50.3033

process LOC100044878, BRCA1, GM9347, DHFR, PHGDH, GM9210, H2-KE6,

GULO, ALOX12

GM7669, LOC630896, ACHE, AHCY, GCLC, CHKB, G6PDX, EIF5A,

GO:0006575~cellular AZIN1, HNRPLL, GM8096, ATP2B2, GM13337, GM8341, GPX4,

amino acid derivative 0.037702 GATA3, GM7993, GPX3, GM6742, CHRNA7, AMD1, GM14680, AMD2, 141 13588 1.597273 1 0.460725 50.3033

metabolic process ODC1, GM9115, GM9252, AMD-PS3, MAT2A, GM6756, GM7901, DBH,

GM9347, DOHH, PHGDH, GM9210

GM7669, LOC630896, ASL, CD74, GM8096, FAR1, GOT2, GM13337,

ELOVL5, ELOVL4, GM8341, ALOX5AP, LIAS, ELOVL7, ELOVL6, GO:0016053~organic acid 0.037702 ENOPH1, LIPT2, GM9252, MAT2A, FA2H, GM6756, CBR4, GM7901, 141 13588 1.597273 1 0.460725 50.3033 biosynthetic process LOC100044878, BRCA1, GM9347, DHFR, PHGDH, GM9210, H2-KE6,

GULO, ALOX12

GM5616, GAR1, GM11847, LOC100044829, DGCR14, HNRPLL, APP,

CDKN2A, CLP1, LOC433064, SRRM2, GPX4, LOC100044383, INTS6, GO:0006396~RNA 0.038959 BAT1A, LSM5, MAGOHB, DBR1, LSM3, LSM2, DDX20, IMP4, LUC7L3, 437 13588 1.300689 1 0.470287 51.47052 processing FTSJ3, CSDC2, EXOSC9, LOC100046744, EMG1, EXOSC7, EXOSC4,

EFTUD2, MAGOH, AARS,

GO:0043281~regulation of CASP8AP2, CASP9, ADORA2A, BAX, CYCS, DIABLO, BIRC5, BAD, 0.039435 50 13588 2.144909 1 0.472837 51.90655 caspase activity EIF2AK3, HIP1

GO:0052548~regulation of 0.039435 CASP8AP2, CASP9, ADORA2A, BAX, CYCS, DIABLO, BIRC5, BAD, 50 13588 2.144909 1 0.472837 51.90655 endopeptidase activity EIF2AK3, HIP1

COL18A1, BMP4, ACVRL1, EGFL7, TNFSF13, TNFSF12, GPI1,

GO:0001525~angiogenesis 0.039486 ANXA2, MAP3K7, ANGPTL6, GPX1, WARS, MEOX2, NUS1, HMOX1, 133 13588 1.612714 1 0.471655 51.95294

MAPK14, DLL4, ITGAV, TNFSF12-TNFSF13, FGF1, ANGPT2, ACVR1

GO:0031098~stress-activ MDFI, MAPK8IP2, MAPK8IP1, MAPK10, MAP2K7, MAPKBP1, ated protein kinase 0.03978 35 13588 2.451325 1 0.47259 52.21969 CDC42EP5, FGD4 signaling pathway

GO:0048002~antigen

processing and 0.03978 H2-OA, H2-EB1, H2-D1, H2-DMB1, IFI30, CD74, H2-DMB2, B2M 35 13588 2.451325 1 0.47259 52.21969 presentation of peptide

antigen

GO:0009411~response to HMGN1, MSH6, CDKN1A, CASP3, GM7862, CASP9, BAX, 0.03978 35 13588 2.451325 1 0.47259 52.21969 UV LOC100044391, GM2992, BRCA2, ERCC3, GM11663

GO:0006364~rRNA EXOSC9, EMG1, GAR1, EXOSC7, EXOSC4, EXOSC2, ERI1, 0.039994 74 13588 1.884042 1 0.472826 52.41295 processing LOC100044829, FBL, DIMT1, DIS3, CDKN2A, IMP4, FTSJ3

GO:0030835~negative

regulation of actin 0.040118 DBNL, LIMA1, CAPZA3, GSN, CAPZB, EPB4.9 21 13588 3.064156 1 0.472291 52.52489 filament

depolymerization

GO:0031023~microtubule

organizing center 0.040118 HAUS3, KIF11, CKAP5, HAUS2, HAUS8, BRCA1 21 13588 3.064156 1 0.472291 52.52489

organization

GO:0019884~antigen

processing and 0.040944 H2-OA, H2-EB1, H2-DMB1, IFI30, CD74, H2-DMB2, B2M 28 13588 2.681137 1 0.477733 53.26292 presentation of

exogenous antigen LOC100044341, HR, CBX4, CBX1, CBX8, CBX5, CDT1, CITED2, GO:0051172~negative ATF6B, DDX20, BHLHE41, EGR1, CTBP1, GTPBP4, MTA2, LEF1, regulation of nitrogen 0.041994 COBRA1, PURA, HHEX, BPTF, CUX1, MTDH, GCLC, BLM, HAT1, 401 13588 1.310481 1 0.484935 54.18496 compound metabolic HEXIM1, GATAD2A, CDA, BHLHE40, DNMT3B, HELLS, HNRNPAB, process MDFI, DNMT3A, MSH6, LOC100045360,

LOC100044341, HR, CBX4, CBX1, CBX8, CITED2, CBX5, CDT1,

GO:0031327~negative EIF4EBP1, INSIG2, ATF6B, DDX20, BHLHE41, LAG3, EGR1, CTBP1,

regulation of cellular 0.042601 GTPBP4, MTA2, LEF1, COBRA1, PURA, HHEX, BPTF, CUX1, 430 13588 1.296922 1 0.488349 54.70993

biosynthetic process EIF2AK3, MTDH, GCLC, HAT1, HEXIM1, GATAD2A, BHLHE40,

DNMT3B, HELLS, HNRNPAB, MDFI, DNMT

GO:0001889~liver 0.042641 MAN2A1, HHEX, GATA6, FOXM1, HLX, HGF, ASL, CITED2, MED1 43 13588 2.244672 1 0.487082 54.74457 development

GO:0007368~determinatio ACVR2A, ACVR2B, KIF3A, FTO, IFT172, ALG5, DNAHC11, ACVR1, 0.042641 43 13588 2.244672 1 0.487082 54.74457 n of left/right symmetry CITED2

GO:0045786~negative CDKN1A, CASP3, LOC100048453, CDKN2A, MAD2L1, GM7334, 0.042641 43 13588 2.244672 1 0.487082 54.74457 regulation of cell cycle HEXIM1, GMNN, BTG3, ATF6B, APBB1

GO:0016072~rRNA EXOSC9, EMG1, GAR1, EXOSC7, EXOSC4, EXOSC2, ERI1, 0.043742 75 13588 1.858921 1 0.494444 55.68215 metabolic process LOC100044829, FBL, DIMT1, DIS3, CDKN2A, IMP4, FTSJ3

GO:0010551~regulation of HMGB1, HMGB2, BMP2, GM12568, LOC100046019, GM10075, specific 0.044086 CITED2, HHEX, DLX2, DLX1, HDAC1, HMG1L1, GATA6, GM5937, 51 13588 2.102852 1 0.495613 55.97112 from RNA polymerase II GATA4, GM5853, LOC637733, GM7468, GM15387, LOC100048378

GO:0032147~activation of ACVR2B, MAPKSP1, CCDC88A, GNAI2, ADORA2A, IKBKG, DGKZ, 0.044086 51 13588 2.102852 1 0.495613 55.97112 protein kinase activity CARTPT, MAPKBP1, CARD10

GO:0052547~regulation of CASP8AP2, CASP9, ADORA2A, BAX, CYCS, DIABLO, BIRC5, BAD, 0.044086 51 13588 2.102852 1 0.495613 55.97112 peptidase activity EIF2AK3, HIP1 GO:0045736~negative

regulation of 0.044188 CDKN1A, CASP3, CDKN2A, HEXIM1 9 13588 4.766465 1 0.494842 56.05658 cyclin-dependent protein

kinase activity

GO:0022407~regulation of 0.044188 GTPBP4, ITGA6, L1CAM, CITED2 9 13588 4.766465 1 0.494842 56.05658 cell-cell adhesion

HMGB1, HMGB2, TESC, BMP2, GM12568, LOC100046019, GM10075, GO:0032583~regulation of CITED2, HHEX, DLX2, DLX1, HDAC1, HMG1L1, GATA6, GM5937, gene-specific 0.044383 67 13588 1.920814 1 0.494814 56.2191 GATA4, LOC100047138, GM5853, LOC637733, GM7468, GM15387, transcription LOC100048378, HNRNPAB

GO:0051222~positive LOC100048076, CRTAM, ADORA2A, GSK3B, LOC100044207, SMAD4, regulation of protein 0.045563 36 13588 2.383232 1 0.502539 57.19297 CASP1, LTB, BAT2, FLNA transport

GM5616, NHP2L1, GM11847, DGCR14, HNRPLL, APLP1, HNRNPA3,

HNRNPM, MOV10, APP, GPX4, CLP1, SRRM2, LOC433064, LSM5, GO:0006397~mRNA 0.045667 BAT1A, DBR1, MAGOHB, GEMIN8, LSM3, DDX20, LSM2, GEMIN6, 262 13588 1.391735 1 0.501769 57.27715 processing LUC7L3, CSDC2, ADARB1, LOC100046744, MAGOH, EFTUD2,

GM6793, CDC5L, MBNL1, GM8396, SLBP

GO:0060011~Sertoli cell 0.045816 ACVR2A, BAX, FSHB 4 13588 8.04341 1 0.501361 57.3985 proliferation

GO:0016093~polyprenol 0.045816 ADNP, DPM1, DPM2 4 13588 8.04341 1 0.501361 57.3985 metabolic process

GO:0000320~re-entry into 0.045816 CCND1, GSK3B, CCNF 4 13588 8.04341 1 0.501361 57.3985 mitotic cell cycle

GO:0019348~dolichol 0.045816 ADNP, DPM1, DPM2 4 13588 8.04341 1 0.501361 57.3985 metabolic process GO:0033627~cell adhesion 0.045816 ICAM1, ITGA6, L1CAM 4 13588 8.04341 1 0.501361 57.3985 mediated by integrin

GO:0016090~prenol 0.045816 ADNP, DPM1, DPM2 4 13588 8.04341 1 0.501361 57.3985 metabolic process

GO:0010216~maintenance 0.045816 DNMT1, CTCF, HELLS 4 13588 8.04341 1 0.501361 57.3985 of DNA methylation

COPA, MSR1, AP1G1, LOC100044514, EIF5A, LOC100044204,

SELENBP1, CLTC, HOOK2, IMMP2L, FAM125A, COPB2, AP2B1, GOPC, GO:0045184~establishmen 0.046759 GM10259, GLE1, KPNB1, KDELR1, COX16, KDELR3, GM10184, RAN, 656 13588 1.22613 1 0.507054 58.15799 t of protein localization GM9797, ARNTL, IPO8, TIMM23, FLNA, BCAP31, MFN2, GM10698,

COPG2, CHMP1B, TIMM8A1,

GO:0007281~germ cell BMP4, HMGB2, AGFG1, CAPZA3, BRCA2, CDC25B, BBS2, DDX25, 0.046882 101 13588 1.698938 1 0.506438 58.25666 development BAX, GOPC, MKKS, CELF1, FANCG, GM16517, ACVR1, FANCC

GO:0042401~biogenic ODC1, GM9115, AMD-PS3, AZIN1, DBH, GATA3, GM7993, GM6742, amine biosynthetic 0.047707 29 13588 2.588684 1 0.511124 58.90919 CHRNA7, AMD1, SMS, GM14680, AMD2 process

GO:0007584~response to BCKDHA, GDAP2, GDAP1, BRCA2, CLIC1, ASL, D17H6S56E-3, 0.047727 76 13588 1.834462 1 0.509719 58.92437 nutrient HMOX1, ATF6B, GATA4, ARSA, CP, MEST

GO:0009799~determinatio ACVR2A, ACVR2B, KIF3A, FTO, IFT172, ALG5, DNAHC11, ACVR1, 0.048033 44 13588 2.193657 1 0.510468 59.16413 n of symmetry CITED2

GO:0009855~determinatio ACVR2A, ACVR2B, KIF3A, FTO, IFT172, ALG5, DNAHC11, ACVR1, 0.048033 44 13588 2.193657 1 0.510468 59.16413 n of bilateral symmetry CITED2

GO:0050905~neuromuscula CLN3, ATP2B2, IGDCC3, APP, FXN, GM2A, ADORA2A, HEXB, AARS, 0.049202 60 13588 1.966167 1 0.517573 60.06704 r process GAA, APLP2

GO:0043193~positive HMGB1, HMGB2, TESC, BMP2, GM12568, LOC100046019, GM10075, 0.051858 37 13588 2.318821 1 0.535124 62.04876 regulation of CITED2, HMG1L1, GATA6, GM5937, GATA4, LOC100047138, gene-specific GM5853, LOC637733, GM7468, GM15387, LOC100048378, HNRNPAB

transcription

GO:0045934~negative LOC100044341, HR, CBX4, CBX1, CBX8, CBX5, CDT1, CITED2,

regulation of ATF6B, DDX20, BHLHE41, EGR1, GTPBP4, CTBP1, MTA2, LEF1, nucleobase, nucleoside, 0.051873 COBRA1, PURA, HHEX, BPTF, CUX1, MTDH, GCLC, BLM, HAT1, 397 13588 1.296671 1 0.533676 62.05934

nucleotide and nucleic HEXIM1, GATAD2A, CDA, BHLHE40, DNMT3B, HELLS, HNRNPAB,

acid metabolic process MDFI, MSH6, DNMT3A, LOC100045360,

GM7669, LOC630896, GCLC, AHCY, G6PDX, HNRPLL, GM8096,

GO:0006790~sulfur HS2ST1, GM13337, GM8341, GPX4, GPX3, LIAS, ENOPH1, LIPT2, 0.052519 94 13588 1.711364 1 0.536661 62.52719 metabolic process GM9252, MOCS2, MAT2A, GM6756, GM7901, LOC100044878,

CSGALNACT1, GM9347, PHGDH, GM9210, EXT1, MGST1

MORF4L1, DERL2, ENOX2, LOC100047012, IGFBP7, LGMN, IGFBP6,

G6PDX, MORF4L2, CXADR, APP, CDKN2A, IDH3G, FXN, HLX, MAPT, GO:0040008~regulation of 0.052817 GATA4, CDA, ACTL6A, HTRA3, CRIM1, CREB1, GM5521, HMGA2, 256 13588 1.382461 1 0.537193 62.74096 growth UBE2E3, BBS2, CD81, HOPX, CELF1, BC048355, MCTS1, APBB1,

GAP43, IGFBP5, ALOX12

COPA, MSR1, AP1G1, LOC100044514, EIF5A, LOC100044204,

SELENBP1, CLTC, HOOK2, IMMP2L, FAM125A, COPB2, AP2B1, GOPC, GO:0015031~protein 0.053682 GM10259, GLE1, KPNB1, KDELR1, COX16, KDELR3, GM10184, RAN, 651 13588 1.219073 1 0.54162 63.35531 transport GM9797, ARNTL, IPO8, TIMM23, BCAP31, MFN2, GM10698, COPG2,

CHMP1B, TIMM8A1, ATG4B,

GM5616, NHP2L1, GM11847, DGCR14, HNRNPA3, HNRNPM, CLP1,

SRRM2, LOC433064, BAT1A, LSM5, DBR1, MAGOHB, GEMIN8, LSM3,

GO:0008380~RNA splicing 0.053778 DDX20, LSM2, GEMIN6, LUC7L3, LOC100046744, MAGOH, EFTUD2, 201 13588 1.440611 1 0.540744 63.4227

GM6793, CDC5L, MBNL1, DDX39, PPIH, GM8186, CELF1, GM7879,

ESRP2, CWC22, LOC1000485 LOC100044341, HR, CBX4, CBX1, CBX8, CBX5, CDT1, CITED2, GO:0010558~negative EIF4EBP1, ATF6B, DDX20, BHLHE41, LAG3, EGR1, CTBP1, GTPBP4, regulation of 0.054422 MTA2, LEF1, COBRA1, PURA, HHEX, BPTF, CUX1, EIF2AK3, MTDH, 418 13588 1.28284 1 0.543596 63.87289 macromolecule GCLC, HAT1, HEXIM1, GATAD2A, BHLHE40, DNMT3B, HELLS, HHATL, biosynthetic process HNRNPAB, MDFI, DNMT3

GO:0002695~negative LOC100046168, CASP3, CDKN2A, ADORA2A, HLX, HMOX1, CD274, regulation of leukocyte 0.054454 53 13588 2.023499 1 0.54229 63.89484 IL4RA, NDFIP1, LAG3, CD74 activation

GO:0050866~negative LOC100046168, CASP3, CDKN2A, ADORA2A, HLX, HMOX1, CD274, regulation of cell 0.054454 53 13588 2.023499 1 0.54229 63.89484 IL4RA, NDFIP1, LAG3, CD74 activation

LOC100044207, DEK, ASAH1, B2M, FOS, EIF4EBP1, D17H6S56E-3,

HMOX1, ATF6B, CHRNA5, CHRNA7, LBP, CREB3L3, CASP1, EIF2B2, GO:0010033~response to 0.054456 AKT3, EGR1, IRAK1, HSP90AA1, LYN, LY96, AARS, LOC100046019, 505 13588 1.252967 1 0.540796 63.89671 organic substance ADIPOR1, CLIC1, MMP13, LPIN1, MAPK1, ACVR2B, CCND1, HMG1L1,

MAPK3, GM5853, LO

ALDH8A1, CYB5R3, CDIPT, CYB5R1, GDF1, HSD17B2, HSD3B7,

CHKB, HEXB, LSS, CD74, FDFT1, FAR1, ACBD3, LPCAT1, INSIG2, GO:0008610~lipid 0.054992 ELOVL5, ELOVL4, ALOX5AP, ELOVL7, ELOVL6, PTDSS1, AGPAT3, 285 13588 1.35468 1 0.542889 64.26675 biosynthetic process A4GALT, FA2H, FDPS, ADNP, CBR4, BRCA1, MBOAT7, LASS1, CD81,

DPM1, MBOAT2, DPM2, H2-K

GO:0009394~2'-deoxyribo

nucleotide metabolic 0.055059 LOC100045567, ADK, DTYMK, DGUOK, PNP, DUT 16 13588 3.351421 1 0.541839 64.31303

process

GO:0030307~positive 0.055059 DERL2, MAPT, CD81, BC048355, ALOX12 16 13588 3.351421 1 0.541839 64.31303 regulation of cell growth GO:0000077~DNA damage 0.05512 CDK1, CCND1, MAPK14, BRE, H2AFX, CHEK1, ATR 30 13588 2.502394 1 0.540754 64.35496 checkpoint

GO:0032312~regulation of 0.056889 GIT1, ARFGAP1, ARFGAP2, ARFGAP3, AGFG1, ASAP1 23 13588 2.797708 1 0.550919 65.54969 ARF GTPase activity

GO:0001933~negative

regulation of protein 0.056889 IBTK, INPP5K, IMPACT, BAX, FKBP1A, BDKRB2 23 13588 2.797708 1 0.550919 65.54969 amino acid

phosphorylation

GO:0009262~deoxyribonuc

leotide metabolic 0.056889 LOC100045567, ADK, DTYMK, DGUOK, BC048355, PNP, DUT 23 13588 2.797708 1 0.550919 65.54969

process

GO:0045137~development LOC100046932, HMGB2, TESC, FST, TAF4A, MSH4, BRCA2, CDH6,

of primary sexual 0.058098 IMMP2L, ACVR2A, BAX, LOC100047138, BIK, FANCG, EIF2B2, 104 13588 1.64993 1 0.55723 66.34447

characteristics FSHB, LHX9, FANCA

GO:0032496~response to 0.058674 MAPK1, IRAK1, LY96, MAPK14, MAPK3, ADH5, LIAS, LBP 38 13588 2.257799 1 0.559412 66.71704 lipopolysaccharide

GO:0032012~regulation of

ARF protein signal 0.058674 GIT1, ARFGAP1, ARFGAP2, ARFGAP3, GBF1, AGFG1, ASAP1, FBXO8 38 13588 2.257799 1 0.559412 66.71704

transduction

HMGB2, MTDH, GNAI2, GM2A, APH1A, ADORA2A, LPAR2, CD74,

GO:0044093~positive CDC42, MAP3K5, GALR1, CASP9, CASP8AP2, DIABLO, CCS, regulation of molecular 0.059626 MAPKBP1, CEACAM1, HIP1, FGD4, MDFI, IRAK1, MAPKSP1, 306 13588 1.331806 1 0.563926 67.32403

function CCDC88A, CYCS, HGF, CDC25B, CARD10, ACVR2B, AKTIP, GNB1,

BAX, IKBKG, CD81, CALM3, DGKZ, CARTPT,

GO:0006997~nucleus 0.060098 CASP3, HMGB2, AGFG1, BAX, ENDOG, GOPC, LMNA, BNIP3, ACIN1 46 13588 2.098281 1 0.56539 67.62117 organization GO:0046365~monosacchari ALDOA, ALDOART1, GNPDA1, ALDOC, HKDC1, ENO2, BAD, GPI1, 0.060185 54 13588 1.986027 1 0.564455 67.67557 de catabolic process MDH2, ENO1

GO:0046364~monosacchari 0.063188 GPD2, GPD1, GNPDA1, GNPNAT1, G6PDX, FBP2, GPI1 31 13588 2.421672 1 0.58125 69.50439 de biosynthetic process

GO:0006914~autophagy 0.063188 CLN3, ATG5, MAP1LC3A, ATG4B, MAP1LC3B, GOPC, ARSA 31 13588 2.421672 1 0.58125 69.50439

ATP2B2, CCND1, NME1, CREB1, EIF2AK3, LOC100046344, CHUK, GO:0007595~lactation 0.063188 31 13588 2.421672 1 0.58125 69.50439 MED1

LOC100048076, CRTAM, ADORA2A, CREB1, GLUD1, LOC100044207, GO:0051050~positive 0.064387 SMAD4, PINK1, LDLRAP1, FLNA, CD47, MIB1, ATP2B2, GSK3B, 132 13588 1.543685 1 0.586862 70.20647 regulation of transport BAX, CARTPT, CASP1, LTB, BAT2, AKT3, HIP1

GO:0048515~spermatid BBS2, HMGB2, AGFG1, CAPZA3, BAX, DDX25, GOPC, MKKS, CELF1, 0.065004 63 13588 1.87254 1 0.588999 70.56229 differentiation FANCG, GM16517

CAV2, OPA1, BNIP3, GM9797, CXADR, MFN2, MAN2A1, DNA2, GO:0007005~mitochondrio 0.065239 IMMP2L, CASP3, TIMM8A1, FXN, BAX, COL4A3BP, MRPL17, 97 13588 1.658435 1 0.588896 70.69633 n organization LOC100046998, DAP3

GNAI2, GM2A, APH1A, ADORA2A, LPAR2, CD74, CDC42, MAP3K5,

GO:0043085~positive GALR1, CASP9, CASP8AP2, DIABLO, CCS, MAPKBP1, CEACAM1, regulation of catalytic 0.065333 HIP1, FGD4, MDFI, IRAK1, MAPKSP1, CCDC88A, CYCS, HGF, 261 13588 1.355977 1 0.587984 70.75018

activity CDC25B, CARD10, ACVR2B, GNB1, BAX, IKBKG, CD81, DGKZ,

CARTPT, EIF2AK3

GO:0008584~male gonad ACVR2A, HMGB2, TESC, BAX, LOC100047138, BIK, FSHB, FANCA, 0.066015 39 13588 2.199907 1 0.590458 71.13606 development LHX9

GO:0021766~hippocampus 0.06657 BBS2, DLX2, DLX1, HDAC1, MKKS, LEF1 24 13588 2.681137 1 0.592177 71.4463 development

GO:0019395~fatty acid 0.06657 HACL1, ACOX1, MAPK14, ADIPOR1, HADHA, ALOX12 24 13588 2.681137 1 0.592177 71.4463 oxidation GO:0030834~regulation of

actin filament 0.06657 DBNL, LIMA1, CAPZA3, GSN, CAPZB, EPB4.9 24 13588 2.681137 1 0.592177 71.4463

depolymerization

GO:0010552~positive HMGB1, HMGB2, BMP2, GM12568, LOC100046019, GM10075, regulation of specific 0.06657 CITED2, HMG1L1, GATA6, GM5937, GATA4, GM5853, LOC637733, 24 13588 2.681137 1 0.592177 71.4463 transcription from RNA GM7468, GM15387, LOC100048378 polymerase II promoter

GO:0034440~lipid 0.06657 HACL1, ACOX1, MAPK14, ADIPOR1, HADHA, ALOX12 24 13588 2.681137 1 0.592177 71.4463 oxidation

GO:0006800~oxygen and GPX1, GPX4, FMO2, GPX3, CYCS, BNIP3, MPV17, CCS, GTF3C2, reactive oxygen species 0.066783 47 13588 2.053637 1 0.591943 71.56454 HNRPLL, FANCC metabolic process

GO:0006081~cellular

aldehyde metabolic 0.06688 ALDH8A1, DHRS4, ADH5, IDH2, ALDH3B1 17 13588 3.154278 1 0.591058 71.61857

process

GO:0034620~cellular

response to unfolded 0.06688 CCND1, DERL2, AARS, ERO1L, EIF2AK3 17 13588 3.154278 1 0.591058 71.61857

protein

GO:0030968~endoplasmic

reticulum unfolded 0.06688 CCND1, DERL2, AARS, ERO1L, EIF2AK3 17 13588 3.154278 1 0.591058 71.61857

protein response

GO:0035235~ionotropic

glutamate receptor 0.071702 CLN3, APP, ATP1A3 5 13588 6.434728 1 0.61609 74.17139

signaling pathway

GO:0032225~regulation of 0.071702 PINK1, CHRNA7, GDNF 5 13588 6.434728 1 0.61609 74.17139 synaptic transmission, dopaminergic

GO:0033137~negative

regulation of 0.071702 INPP5K, BAX, BDKRB2 5 13588 6.434728 1 0.61609 74.17139 peptidyl-serine

phosphorylation

GO:0008631~induction of

apoptosis by oxidative 0.071702 GPX1, CASP3, DIABLO 5 13588 6.434728 1 0.61609 74.17139

stress

GO:0006346~methylation-

dependent chromatin 0.071702 DNMT3A, DNMT3B, HELLS 5 13588 6.434728 1 0.61609 74.17139

silencing

GO:0033599~regulation of mammary gland epithelial 0.071702 CDKN2A, BAX, MED1 5 13588 6.434728 1 0.61609 74.17139

cell proliferation

GO:0006012~ 0.071702 GALK1, GALT, GALE 5 13588 6.434728 1 0.61609 74.17139 metabolic process

GO:0007254~JNK cascade 0.071914 MDFI, MAPK8IP2, MAPK8IP1, MAPK10, MAPKBP1, CDC42EP5, FGD4 32 13588 2.345994 1 0.615785 74.27867

GO:0009116~nucleoside COASY, MAT2A, LOC100045567, PNP2, GM5081, LOC100046344, 0.072766 56 13588 1.915098 1 0.618853 74.70483 metabolic process PNP, NME1, ADK, DHODH, CDA, PRPS1, DUT

GO:0034637~cellular GPD2, CSGALNACT1, GPD1, GNPDA1, GNPNAT1, G6PDX, GYG, FBP2, carbohydrate 0.072766 56 13588 1.915098 1 0.618853 74.70483 GPI1, HS2ST1 biosynthetic process

GO:0001934~positive BMP4, LOC100048076, HMGB1, BMP2, LYN, GM12568,

regulation of protein LOC100046019, SMAD4, GM10075, ACVR2A, HMG1L1, AKTIP, 0.072766 56 13588 1.915098 1 0.618853 74.70483 amino acid GM5937, CD81, GM5853, LOC637733, GM7468, MLST8, GM15387,

phosphorylation FGF1, LOC100048378 LOC100046932, HMGB2, AGFG1, CAPZA3, FST, FEM1B, CITED2,

CDH6, IMMP2L, DDX25, LOC100047138, GOPC, MKKS, FANCG, GO:0003006~reproductive 0.073782 EIF2B2, FANCA, LHX9, FANCC, BMP4, TESC, TAF4A, MSH4, BRCA2, 264 13588 1.340568 1 0.622731 75.20462 developmental process CDC25B, ACVR2A, BBS2, BAX, CELF1, EPOR, BIK, GM16517, FSHB,

BMPR1A, ACVR1, MED1

GO:0042398~cellular ODC1, GM9115, GCLC, AMD-PS3, MAT2A, AZIN1, DBH, GATA3, amino acid derivative 0.073908 48 13588 2.010852 1 0.621963 75.2657 GM7993, GM6742, CHRNA7, AMD1, GM14680, SMS, AMD2 biosynthetic process

GO:0043393~regulation of 0.075494 GTPBP4, AKTIP, ATR, EIF2AK3 11 13588 3.899835 1 0.628671 76.02503 protein binding

GO:0008156~negative

regulation of DNA 0.075494 GTPBP4, GMNN, BRCA2, CDT1 11 13588 3.899835 1 0.628671 76.02503

replication

GO:0042692~muscle cell BMP4, CAV2, LGALS1, MBNL1, CXADR, ITGB1, DVL1, GPX1, GPHN, 0.076284 117 13588 1.558267 1 0.631251 76.39532 differentiation APP, ATG5, GATA6, DNER, DYRK1B, GATA4, BIN1, ACVR1

FOSL2, IL6ST, TNFSF13, TNFSF12, PNP, HLX, ATF6B, GM6742,

GO:0008284~positive FGF1, EGFR, CCKBR, LYN, D17WSU104E, LOC100046019, HRAS1,

regulation of cell 0.076786 PURA, HMG1L1, GRN, CD81, GM5853, LOC637733, GM7468, 284 13588 1.321687 1 0.63236 76.6275

proliferation TNFSF12-TNFSF13, LOC100048378, MED1, ALOX12, HMGB1, DERL2,

CNBP, GNAI2, BLM, GM12568, FOX

GO:0030837~negative DBNL, LOC100048142, CAPZA3, GSN, TMSB10, GM9844, CAPZB, regulation of actin 0.077107 25 13588 2.573891 1 0.632564 76.77508 EPB4.9 filament polymerization

GO:0008217~regulation of ACE, HMOX1, G6PDX, ADRA1B, ADH5, AVPR1A, CARTPT, GUCY1A3, 0.077161 65 13588 1.814923 1 0.631438 76.79954 blood pressure CHRNA7, ATP1A1, AGTRAP

GO:0016458~gene 0.079622 DNMT3A, MOV10, CLP1, ATF6B, DNMT1, ERI1, HAT1, CBX8, 57 13588 1.881499 1 0.642087 77.89984 silencing DNMT3B, HELLS

GO:0051241~negative GNAI2, LGMN, NDFIP1, ATP1A1, CXADR, ANXA2, LOC100046168, regulation of 0.079861 BBS2, INHBA, FXN, HMOX1, GUCY1A3, CARTPT, CHRNA7, EIF2AK3, 100 13588 1.608682 1 0.641858 78.00416 multicellular organismal H47 process

GO:0051297~ 0.0799 HAUS3, KIF11, HAUS2, HAUS8, BRCA1 18 13588 2.979041 1 0.64067 78.02108 organization

GO:0014706~striated CAV2, EGLN1, FKBP1A, MBNL1, CXADR, FLNB, ITGB1, DVL1, GPX1, muscle tissue 0.081082 127 13588 1.520014 1 0.644932 78.52909 GPHN, APP, ATG5, MEOX2, GATA6, MAPK14, HLX, DNER, GATA4 development

GO:0006919~activation of 0.081295 CASP8AP2, CASP9, BAX, CYCS, DIABLO, EIF2AK3, HIP1 33 13588 2.274904 1 0.644573 78.61927 caspase activity

GO:0021761~limbic system 0.081295 BBS2, DLX2, DLX1, HDAC1, BAX, MKKS, LEF1 33 13588 2.274904 1 0.644573 78.61927 development

GO:0002237~response to

molecule of bacterial 0.081475 MAPK1, IRAK1, LY96, MAPK14, MAPK3, ADH5, LIAS, LBP, B2M 49 13588 1.969815 1 0.644062 78.69536

origin

GO:0044272~sulfur CSGALNACT1, GCLC, MAT2A, LIAS, ENOPH1, EXT1, LIPT2, compound biosynthetic 0.082284 41 13588 2.092594 1 0.646501 79.03425 LOC100044878, HS2ST1 process

BMP4, DNMT3A, HMGB2, GNPDA1, AGFG1, CAPZA3, BRCA2, FEM1B, GO:0048610~reproductive 0.082541 ITGB1, CDC25B, BBS2, ACVR2A, DDX25, BAX, GOPC, ARSA, MKKS, 173 13588 1.425807 1 0.646352 79.14107 cellular process CELF1, FANCG, GM16517, FSHB, ACVR1, FANCC

GO:0046777~protein amino EGFR, IRAK1, LYN, MAP3K3, CAMK2D, CAMK2B, FERT2, CAD, 0.083734 66 13588 1.787424 1 0.650514 79.62879 acid autophosphorylation EIF2AK3, MAP3K12, CAMKK2

GO:0034660~ncRNA 0.086775 GAR1, F13A1, LOC100044829, ERI1, DIMT1, ADAT1, WARS, 202 13588 1.380387 1 0.662874 80.82472 metabolic process CDKN2A, METTL1, CLP1, INTS6, IMP4, FTSJ3, DUS3L, CARS,

EXOSC9, EXOSC7, EMG1, EXOSC4, AARS, EXOSC2, DALRD3, FBL,

EARS2, DIS3, HARS, FARSA

LOC100048076, HMGB1, MSR1, GM12568, IL4RA, CLU, JAG1, PNP,

GO:0045597~positive CD74, GM10075, GATA6, HLX, MAPT, GM5937, GATA4,

regulation of cell 0.090754 LOC100047138, ACIN1, BMP4, TESC, BMP2, HSP90AA1, 175 13588 1.409512 1 0.678728 82.28895

differentiation LOC100045567, LOC100046019, SMAD4, BAD, ID2, HMG1L1, ETS1,

MAPK14, HOPX, GM5853, LOC637733, GM7468,

GO:0006767~water-solubl

e vitamin metabolic 0.091322 GCLC, FOLR1, G6PDX, FLAD1, GULO, MMAB, ALDH9A1 34 13588 2.207995 1 0.6798 82.48945

process

CADM3, AP1G1, EIF5A, GRIN3B, SELENBP1, LOC100044204,

FAM125A, HOOK2, GLE1, RAN, TMSB10, ARNTL, BCAP31, GM10698, GO:0008104~protein 0.092688 COPG2, TIMM8A1, LYST, GM10349, COPZ2, ARFGAP1, CHMP2A, 753 13588 1.167879 1 0.684165 82.96216 localization ARFGAP2, AFTPH, DERL2, ARFGAP3, GM10333, COPZ1, GM10233,

CACNB1, CHCHD4, CD74, MIA3, TOM

GO:0007030~Golgi 0.093933 CTBP1, GORASP1, LOC100045360, GORASP2, GOLGA5 12 13588 3.574849 1 0.687955 83.38238 organization

GO:0050433~regulation of 0.093933 ADORA2A, CARTPT, PINK1, CHRNA7 12 13588 3.574849 1 0.687955 83.38238 catecholamine secretion

GO:0031663~lipopolysacc

haride-mediated 0.093933 MAPK1, IRAK1, MAPK14, MAPK3 12 13588 3.574849 1 0.687955 83.38238

signaling pathway

GO:0046677~response to 0.094071 ALPL, ID1, ENDOG, PPP2CB, HIATL1, LOC100044385 19 13588 2.822249 1 0.687216 83.42843 antibiotic

GO:0043525~positive 0.094071 EPHA7, CASP9, BAX, LTB, BAT2 19 13588 2.822249 1 0.687216 83.42843 regulation of neuron

apoptosis

GO:0006541~glutamine GM7669, LOC630896, GM9252, CTPS, CAD, CTPS2, GM6756, ASL, 0.094071 19 13588 2.822249 1 0.687216 83.42843 metabolic process GM7901, GM8096, GM9347, GM13337, GM8341, PHGDH, GM9210

GO:0030262~apoptotic 0.094071 CASP3, BAX, ENDOG, BNIP3, ACIN1 19 13588 2.822249 1 0.687216 83.42843 nuclear changes

GO:0051693~actin 0.094071 DBNL, CAPZA3, GSN, CAPZB, EPB4.9 19 13588 2.822249 1 0.687216 83.42843 filament capping

GO:0007286~spermatid BBS2, HMGB2, AGFG1, CAPZA3, DDX25, GOPC, MKKS, CELF1, 0.094469 59 13588 1.81772 1 0.687533 83.56031 development FANCG, GM16517

BMP4, LOC100046932, HMGB2, TESC, FST, TAF4A, MSH4, BRCA2, GO:0048608~reproductive 0.095735 FEM1B, CDH6, ACVR2A, IMMP2L, BAX, LOC100047138, BIK, FANCG, 130 13588 1.484937 1 0.691329 83.97365 structure development EIF2B2, FSHB, LHX9, FANCA

LOC100046932, HMGB2, TESC, FST, TAF4A, MSH4, BRCA2, CDH6, GO:0007548~sex 0.095735 IMMP2L, ACVR2A, BAX, LOC100047138, BIK, FANCG, EIF2B2, 130 13588 1.484937 1 0.691329 83.97365 differentiation FSHB, LHX9, FANCA, BMPR1A, MED1

LOC100048076, HMGB1, MSR1, GM12568, FST, IL4RA, CLU, JAG1,

GO:0051094~positive PNP, GM10075, CD74, CDKN2A, GATA6, GM5937, HLX, MAPT,

regulation of 0.09688 GATA4, LOC100047138, ACIN1, BMP4, TESC, BMP2, HSP90AA1, 214 13588 1.353097 1 0.694582 84.33886

developmental process LOC100045567, LOC100046019, SMAD4, BAD, HMG1L1, ID2, ETS1,

MAPK14, BAX, GM5853, HOPX,

CHURC1, CBX4, MED22, MED21, MED20, CBFB, CITED2, MAGED1,

GO:0006357~regulation of FOS, APP, GATA6, GATA3, GATA4, BRD7, DDX20, BHLHE41, EGR1,

transcription from RNA 0.097191 ELP3, CTBP1, MTA2, TAF4A, LOC100046019, LEF1, ARNTL, HES6, 616 13588 1.183878 1 0.694526 84.4367

polymerase II promoter MED10, MED19, HHEX, INHBA, MED4, BRWD1, BPTF, HMG1L1,

GM5853, LOC100046682, LOC6 HMGB1, TESC, GM12568, LOC100046019, NDFIP1, JAG1, GM10075, GO:0045637~regulation of LOC100046168, ID2, HMG1L1, ETS1, GM5937, MAPK14, myeloid cell 0.097928 51 13588 1.892567 1 0.696133 84.66614 LOC100047138, GM5853, CARTPT, LOC637733, GM7468, ACIN1, differentiation GM15387, LOC100048378

DLC1, LOC100048076, CAV2, ADORA2A, IFITM3, IFI30, CXADR,

GO:0008285~negative CD9, KISS1R, CASP3, CDKN2A, CDKN2C, HMOX1, GATA3,

regulation of cell 0.098982 LOC100047138, CSK, LTB, BMP4, BMP2, GTPBP4, TESC, NDFIP1, 224 13588 1.340568 1 0.698945 84.98879

proliferation SMAD4, MFN2, LOC100046168, CDKN1A, EEF1E1, BAX, CD274,

BMP7, BAT2