Table S3. Up or down regulated genes in Tcof1 over-expressed neuroblastoma N1E-115 cells involved in differentbiological process analysed by DAVID database P Pop Pop Fold Term Genes Bonferroni Benjamini FDR Value Hits Total Enrichment DBF4, AURKA, AURKB, CDC16, GM8416, APP, GM13337, CDKN2A, CUL7, CASP8AP2, CDKN2C, INCENP, ATF6B, H2AFX, CCNA2, CDCA5, GO:0007049~cell cycle 5.62E-15 ASPM, STAG1, ANAPC1, ANAPC2, GM14176, GM5951, RAN, LIG1, 611 13588 2.088741 1.87E-11 1.87E-11 1.03E-11 MAPK1, MAD2L1, LOC100044742, LOC100047340, RCC2, MAPK3, ARL8B, ANAPC7, AKAP8, MCT MAD1L1, DBF4, AURKA, CDC16, AURKB, GM8416, APP, INCENP, ATF6B, GM5593, CDCA5, CCNA2, ASPM, CABLES1, STAG1, ANAPC1, GO:0000278~mitotic cell 1.12E-13 CDC6, CDK1, ANAPC2, KIF11, GM14176, ANP32B, RAN, DSN1, 244 13588 2.769043 3.70E-10 1.85E-10 2.04E-10 cycle CCNF, UBE2I, HMGA2, CDK2, CCND1, MAD2L1, RCC2, LOC100047340, BUB1B, MAPRE2, AKAP8, HA MAD1L1, GM15452, CDC16, AURKB, GM8416, CCNE2, CCNE1, CDC42, CDC45, CDKN2A, CDCA7, EVI5, INCENP, GM5593, CDCA5, CCNA2, GO:0051301~cell division 2.95E-12 CABLES1, ASPM, STAG1, ANAPC1, CDC7, CDC6, CDK1, ANAPC2, 281 13588 2.518933 9.72E-09 3.24E-09 5.37E-09 KIF11, GM14176, RAN, DSN1, LIG1, CCNF, UBE2I, CDK7, HMGA2, CDK4, CDK2, MCM5, CCND MAD1L1, CDC16, AURKB, GM8416, INCENP, ATF6B, GM5593, CDCA5, CCNA2, ASPM, STAG1, ANAPC1, CDC6, ANAPC2, CDK1, KIF11, GO:0000087~M phase of 4.39E-12 GM14176, RAN, DSN1, CCNF, UBE2I, HMGA2, CDK2, MAD2L1, RCC2, 194 13588 2.874621 1.45E-08 3.62E-09 7.99E-09 mitotic cell cycle LOC100047340, BUB1B, MAPRE2, AKAP8, MAPRE1, ANAPC7, ARL8B, HAUS8, HAUS3, FZR1, H MAD1L1, CDC16, AURKB, GM8416, INCENP, ATF6B, GM5593, CDCA5, GO:0007067~mitosis 2.45E-11 CCNA2, ASPM, STAG1, ANAPC1, CDC6, ANAPC2, CDK1, KIF11, 190 13588 2.822249 8.08E-08 1.62E-08 4.46E-08 GM14176, RAN, DSN1, CCNF, UBE2I, HMGA2, CDK2, MAD2L1, RCC2, LOC100047340, BUB1B, MAPRE2, AKAP8, MAPRE1, ANAPC7, ARL8B, HAUS8, HAUS3, FZR1, H MAD1L1, CDC16, AURKB, GM8416, INCENP, ATF6B, GM5593, CDCA5, CCNA2, ASPM, STAG1, ANAPC1, CDC6, ANAPC2, CDK1, KIF11, GO:0000280~nuclear 2.45E-11 GM14176, RAN, DSN1, CCNF, UBE2I, HMGA2, CDK2, MAD2L1, RCC2, 190 13588 2.822249 8.08E-08 1.62E-08 4.46E-08 division LOC100047340, BUB1B, MAPRE2, AKAP8, MAPRE1, ANAPC7, ARL8B, HAUS8, HAUS3, FZR1, H MAD1L1, DBF4, GM15452, CDC16, AURKB, GM8416, APP, INCENP, ATF6B, GM5593, H2AFX, CDCA5, FANCA, CCNA2, CABLES1, ASPM, GO:0022403~cell cycle 6.45E-11 STAG1, ANAPC1, CDC6, CDK1, ANAPC2, KIF11, GM14176, ANP32B, 328 13588 2.288775 2.13E-07 3.54E-08 1.17E-07 phase RAN, DSN1, CCNF, UBE2I, HMGA2, CDK2, KLHDC3, CCND1, MAD2L1, RCC2, LOC100047340, MAD1L1, CDC16, AURKB, GM8416, INCENP, ATF6B, GM5593, CDCA5, CCNA2, ASPM, STAG1, ANAPC1, CDC6, ANAPC2, CDK1, KIF11, GO:0048285~organelle 9.86E-11 GM14176, RAN, DSN1, CCNF, UBE2I, HMGA2, CDK2, MAD2L1, RCC2, 197 13588 2.721966 3.25E-07 4.64E-08 1.79E-07 fission LOC100047340, BUB1B, MAPRE2, AKAP8, MAPRE1, ANAPC7, ARL8B, HAUS8, HAUS3, FZR1, H LOC630896, MAD1L1, DBF4, GM15452, CDC16, AURKB, GM8416, GM8096, APP, CGREF1, GM13337, CDKN2A, INCENP, ATF6B, GO:0022402~cell cycle 1.83E-10 GM5593, H2AFX, CCNA2, CDCA5, FANCA, CABLES1, ASPM, STAG1, 393 13588 2.128536 6.03E-07 7.54E-08 3.33E-07 process ANAPC1, CDC6, ANAPC2, CDK1, KIF11, GM14176, ANP32B, DSN1, RAN, CCNF, UBE2I, HMGA2, CDK2, MAD1L1, GM15452, CDC16, AURKB, GM8416, INCENP, ATF6B, GM5593, H2AFX, CDCA5, FANCA, CCNA2, ASPM, STAG1, ANAPC1, GO:0000279~M phase 2.29E-09 283 13588 2.273755 7.55E-06 8.39E-07 4.17E-06 CDC6, CDK1, ANAPC2, KIF11, GM14176, RAN, DSN1, CCNF, UBE2I, HMGA2, CDK2, KLHDC3, MAD2L1, RCC2, LOC100047340, BUB1B, MAPRE2, AKAP8, HAUS8, ARL8B, HMGN1, MORF4L1, KIF22, MORF4L2, HNRPLL, FANCM, GPX1, ANKRD17, CASP3, CASP9, MAP1LC3A, ATG5, COL4A3BP, HMOX1, GO:0033554~cellular 1.03E-07 AEN, GPX4, GPX3, GM2992, H2AFX, FANCG, MAPKBP1, MAP2K7, 404 13588 1.911305 3.38E-04 3.38E-05 1.87E-04 response to stress FANCA, FANCC, CLN3, CDK1, DDB1, LIG1, AARS, CCDC47, GM5806, GTF2H2, MAPK1, CCND1, BTG2, LO DBF4, CITED2, CDT1, CSNK2A2, CCNE2, CDC42, CCNE1, APP, CASP3, CDKN2A, CUL7, ATF6B, CDK5RAP3, H2AFX, LTB, CABLES1, GO:0051726~regulation of 1.40E-07 CDK1, GTPBP4, GM7334, CCNI, LOC100046019, HERC2, CDK4, 214 13588 2.305276 4.62E-04 4.20E-05 2.55E-04 cell cycle HRAS1, PURA, CCND1, MAD2L1, HMG1L1, BTG3, GM5853, LOC637733, CDK11B, GM7468, BAT2, LOC GO:0006270~DNA 2.11E-07 CCNE2, CCNE1, CDC45, MCM7, MCM2, MCM3, MCM4, MCM5, MCM6 10 13588 9.652092 6.95E-04 5.79E-05 3.84E-04 replication initiation MORF4L1, HMGN1, MORF4L2, CBX4, GM13646, INO80, CBX1, CBX8, CBX6, CBX5, HIST1H2BP, HIST1H2BM, HIST1H2BN, H2AFV, GO:0006325~chromatin 3.12E-07 HIST1H2BL, HIST1H2BJ, H2AFZ, H2AFX, MTA2, LOC100045490, 315 13588 2.008725 0.001026 7.90E-05 5.67E-04 organization HMG20A, HDAC11, H2AFJ, KDM2B, A730008H23RIK, GM11277, GM11276, ASF1B, DNMT3B, ASF1A, GM1 HMGN1, MORF4L1, MORF4L2, CBX4, GM13646, INO80, CBX1, CBX8, CBX6, CBX5, HIST1H2BP, HIST1H2BM, HIST1H2BN, H2AFV, GO:0051276~chromosome 4.72E-07 HIST1H2BL, ATF6B, HIST1H2BJ, H2AFZ, H2AFX, ACIN1, CDCA5, 404 13588 1.858213 0.001553 1.11E-04 8.59E-04 organization MTA2, LOC100045490, HMG20A, HDAC11, H2AFJ, KDM2B, MAD2L1, AKAP8, BLM, A730008H23RIK, GM MORF4L1, CBX4, GM13646, CBX1, CBX8, CBX6, CBX5, HIST1H2BP, GO:0006333~chromatin 4.97E-07 LOC100047898, HIST1H2BM, HIST1H2BN, H2AFV, HIST1H2BL, 109 13588 2.85332 0.001636 1.09E-04 9.04E-04 assembly or disassembly GM9531, HIST1H2BJ, H2AFZ, H2AFX, LOC100045490, MCM2, H2AFJ, NPTXR, HIST1H2AB, HIST1H2AC, HIST1H2AG, HIST1H2AD, A730008H23RIK, HIST1H2AE, HIST2 AURKA, LPAR2, AURKB, GM8416, MAP3K7, CSNK2A2, APP, MAP3K5, MAP2K7, EGFR, TYRO3, MAPKSP1, CSNK1G1, LOC100046344, GO:0016310~phosphorylat 8.22E-06 MAP4K3, MAP4K4, MAPK1, NME1, MAPK3, CARTPT, MST1R, EIF2AK3, 718 13588 1.538479 0.026717 0.001691 0.014957 ion GNAI2, ERBB3, CHEK1, ADRBK1, ATP6V1B2, ATP6V0B, CD74, FGD4, MDFI, ATR, HGF, GLYCTK, ATP5D, FIGNL1, ATP10A, ATP5G2, ATP6V1B2, PNP, ATP5G3, ATP6V0B, CANT1, ATP2B2, DHODH, ENTPD2, IMPDH2, GO:0009259~ribonucleoti 9.03E-06 LOC100045567, GM5081, ATP1A3, ATP1A1, AMPD2, ATP13A2, 125 13588 2.488095 0.029301 0.001748 0.016425 de metabolic process AMPD3, LOC100046344, ATP6V1D, GART, ATP6V1A, ATP2C2, ATP6V0E2, NME1, ATP8A2, ADSL, ATP5A1, ATP6V0A2, STYX, LPAR2, AURKA, AURKB, GM8416, CSNK2A2, MAP3K7, APP, MAP3K5, MAP2K7, EGFR, TYRO3, MAPKSP1, CSNK1G1, GM5951, GO:0006796~phosphate 1.20E-05 LOC100046344, MAP4K3, MAPK1, MAP4K4, LOC100044742, NME1, 866 13588 1.473696 0.038636 0.002187 0.021761 metabolic process MAPK3, CARTPT, MST1R, EIF2AK3, GM8783, GNAI2, ERBB3, DUSP10, CHEK1, ADRBK1, ATP6V1B2, STYX, LPAR2, AURKA, AURKB, GM8416, CSNK2A2, MAP3K7, APP, MAP3K5, MAP2K7, EGFR, TYRO3, MAPKSP1, CSNK1G1, GM5951, GO:0006793~phosphorus 1.20E-05 LOC100046344, MAP4K3, MAPK1, MAP4K4, LOC100044742, NME1, 866 13588 1.473696 0.038636 0.002187 0.021761 metabolic process MAPK3, CARTPT, MST1R, EIF2AK3, GM8783, GNAI2, ERBB3, DUSP10, CHEK1, ADRBK1, ATP6V1B2, GO:0034404~nucleobase, ATP5D, CTPS, G6PDX, ATP10A, DTYMK, ATP5G2, CTPS2, CAD, nucleoside and ATP6V1B2, ATP5G3, PNP, ATP6V0B, ATP2B2, DHODH, GUCY1A3, 1.81E-05 179 13588 2.156892 0.05785 0.003131 0.032909 nucleotide biosynthetic IMPDH2, ADSSL1, LOC100045567, GM5081, ATP1A3, ATP1A1, process AMPD2, ATP13A2, AMPD3, ATP6V1D, LOC100046344, GART, ATP6V1A, ATP2C2, DHFR, ATP6V0E2, NME1, ATP5D, CTPS, G6PDX, ATP10A, DTYMK, ATP5G2, CTPS2, CAD, GO:0034654~nucleobase, ATP6V1B2, ATP5G3, PNP, ATP6V0B, ATP2B2, DHODH, GUCY1A3, nucleoside, nucleotide 1.81E-05 IMPDH2, ADSSL1, LOC100045567, GM5081, ATP1A3, ATP1A1, 179 13588 2.156892 0.05785 0.003131 0.032909 and nucleic acid AMPD2, ATP13A2, AMPD3, ATP6V1D, LOC100046344, GART, biosynthetic process ATP6V1A, ATP2C2, DHFR, ATP6V0E2, NME1, ATP5D, LOC630896, CTPS, DTYMK, ATP10A, G6PDX, CAD, PNP, GO:0044271~nitrogen GM8096, GOT2, ATP2B2, GM13337, GATA3, GUCY1A3, CHRNA7, compound biosynthetic 2.01E-05 GM6742, ENOPH1, IMPDH2, HSP90AA1, ATP6V1D, LOC100046344, 302 13588 1.846611 0.0641 0.003307 0.036584 process ATP6V1A, ATP2C2, NME1, ADK, ADSL, FLAD1, SMS, PRPS1, GM7669, ATP5G2, AZIN1, CTPS2, ATP6 ATP5D, CTPS, G6PDX, ATP10A, DTYMK, ATP5G2, CTPS2, ATP6V1B2, ATP5G3, PNP, ATP6V0B, ATP2B2, DHODH, GUCY1A3, IMPDH2, GO:0009165~nucleotide 2.40E-05 ADSSL1, LOC100045567, GM5081, ATP1A3, ATP1A1, AMPD2, 174 13588 2.157236 0.076163 0.003765 0.043747 biosynthetic process ATP13A2, AMPD3, ATP6V1D, LOC100046344, GART, ATP6V1A, ATP2C2, DHFR, ATP6V0E2, NME1, ADK, ATP5D, ATP10A, ATP5G2, ATP6V1B2, PNP, ATP5G3, ATP6V0B, ATP2B2, DHODH, IMPDH2, LOC100045567, GM5081, ATP1A3, GO:0009260~ribonucleoti 2.43E-05 ATP1A1, AMPD2, LOC100046344, ATP6V1D, AMPD3, ATP13A2, 111 13588 2.512056 0.076987 0.003635 0.04424 de biosynthetic process GART, ATP6V1A, ATP2C2, ATP6V0E2, NME1, ATP8A2, ADSL, ATP5A1, ATP6V0A2, PRPS1 GO:0007033~vacuole CLN3, HEXB, ACP2, FIG4, HOOK2, MAN2A1, MAP1LC3A, AKTIP, 3.19E-05 34 13588 4.100562 0.09964 0.004553 0.057957 organization ATG5, LYST, GAA, CLN5, GBA GM13646, HIST1H2BP, LOC100047898, HIST1H2BM, HIST1H2BN, GO:0006323~DNA packaging 4.22E-05 H2AFV, HIST1H2BL, GM9531, HIST1H2BJ, ATF6B, H2AFZ, H2AFX, 101 13588 2.548407 0.129828 0.005778 0.076782 ACIN1, CDCA5, MTA2, LOC100045490, H2AFJ, MCM2, AKAP8, HIST1H2AB, HIST1H2AC, HIST1H2AG, HIST1H2AD, HIST1H2AE, A730008H23RIK, HIST2H3C1, GM1127 ATP5D, FIGNL1, ATP10A, ATP5G2, ATP6V1B2, PNP, ATP5G3, GO:0009150~purine ATP6V0B, ATP2B2, ENTPD2, IMPDH2, LOC100045567, ATP1A3, ribonucleotide metabolic 8.28E-05 ATP1A1, AMPD2, LOC100046344, ATP6V1D, AMPD3, ATP13A2, 119 13588 2.343178 0.238639 0.010847 0.150482 process GART, ATP6V1A, ATP2C2, ATP6V0E2, NME1, ATP8A2, ADSL, ATP5A1, ATP6V0A2 HMGN1, MORF4L1, KIF22, FHIT, LOC100044969,