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Abstracts of Scientific Presentations 2018 AALAS National Meeting Baltimore, Maryland Journal of the American Association for Laboratory Animal Science Vol 57, No 5 Copyright 2018 September 2018 by the American Association for Laboratory Animal Science Pages 534–642 Abstracts of Scientific Presentations 2018 AALAS National Meeting Baltimore, Maryland Poster Sessions once approximately every 3 y. The purpose of this in-person training is to review protocol requirements and campus-specific policies and P1 Food for Thought: The Development of Drug-loaded Diets to guidelines that involve survival surgery to assure that quality Improve Both Science and Welfare standards are being met regarding the administration of anesthetics as well as pre-, intra-, and postoperative analgesics. These meetings, held AA Ritchie*, P Clarke, P Collier, A Grabowska by the training and compliance staff members, also provide laboratory personnel with an opportunity to obtain guidance on best practices or Cancer Biology, University of Nottingham, Nottingham, United review any aspects of their protocols that require clarification. Since its Kingdom inception in 2009, this important component of postapproval monitoring has identified multiple instances of significant As an in vivo cancer unit, we grow human tumors in immunodeficient incongruencies between approved protocols and surgical records mice such as CD-1 nude, which may require the addition of hormones reviewed, as well as internal protocol contradictions. The most to promote the growth of prostate and breast tumors. Traditionally, the commonly identified issues are postoperative analgesia not being supplement was delivered by subcutaneous slow-release pellets. administered per protocol (for example, 1 of the multimodal analgesics However, due to supply issues with the 5-α-DHT pellets, we had to is missing, dose intervals and quantities not followed), missing develop another way to provide this hormone. We decided the best documentation, and inadequate surgical preparation. At our campus, method for both staff and animals would be to supply it in a fortified 210 laboratories are currently approved to conduct survival surgery diet, which would be less invasive and stressful to the animals while and 21 of them (10%) had noncompliance issues identified between being simpler for the staff to deliver. We worked with a commercial 01/01/2016 and 06/30/2018. Only 3 of the 21 labs had never had a diet company to formulate and produce the diet to ensure correct PASSR. For the 18 labs that did have one, the average number of days dosage delivery. Then we tested it using the LNCaP prostate tumor cell elapsed from the time of training to the time at which we identified a line and found it to be as effective in stimulating growth as the pellets. noncompliance issue was 705 with a very wide range (4 days to nearly After this success, we decided to adopt this same method for 5 years). In order to evaluate the effectiveness of this model, 17-β-Estradiol delivery, because these pellets can also cause additional correlations (or lack of) between noncompliance instances found side effects such as bladder calculi and urine scald, which we hoped during semiannual inspections and time elapsed since last PASSR, the would be alleviated by changing the delivery method. A test using the presence of PI during the meeting, and other potentially influential MCF-7 breast tumor cell line demonstrated that growth, while slower factors will be presented, as well as lessons learned and potential limits than in the pellet bearing mice, was sufficient for our studies, with no of this model. side effects apart from slight urinary retention, which was eliminated by removing the fortified diet for a few days. This led us to consider P3 Operant Conditioning of Laboratory Beagles whether oral therapeutic drugs could also be delivered via diet, since * ensuring the required dose is achieved via drinking water is difficult, CM Allen, A Carlson due to spillage or reluctance to drink water containing unpleasant tasting compounds. Also, oral dosing can be stressful with welfare Comparative Medicine, AbbVie, North Chicago, IL implications for the animal, requiring frequent restraint and invasive procedures. To this end, we have recently been involved in a therapy We have a large (350+) colony of chronically housed beagles. In early trial whereby a novel test compound for oral delivery was formulated 2016, several of our animal care technicians came up with the idea of as a diet. Administration via diet provides a simple solution for oral training the beagles with some basic commands in order to help the drug delivery and is easily transferable to a broad range of other techs better perform their husbandry duties. Examples of behaviors for animal model systems requiring regular oral dosing of substances such training included dogs that would refuse to move into their home cage as stimulation of transgenic models. It is, therefore, a major refinement for feeding/separating, dogs that would leap out of the cage when the in welfare terms by reducing the need for invasive implants or door was opened, dogs that would keep their feet in their food bowls injection regimes and by reducing side effects, while still generating when the techs would attempt to remove the bowl. We began with a consistent scientific outcomes. small pool of 10 dogs, the worst offenders of these behaviors, and created a plan using a clicker and target training to teach the dogs to P2 The Postapproval Survival Surgery Review: A Postapproval move on command and to hold still when the door to their cage was Monitoring Tool to Evaluate Compliance and Improve Animal opened. In 2018, we have now successfully trained over 150 dogs using Welfare operant conditioning strategies. Our dog training program has also grown to include the training of dogs displaying stereotypic and other C Elkhoraibi, A Cowell*, L Carbone concerning behaviors. We describe the processes we have used in our training, our success rate, maintenance of training, and some obstacles Institutional Animal Care & Use Program, University of California San that we have faced along the way. Francisco, San Francisco, CA P4 Accurate Animal Tracking: From Weaning to Necropsy In order to ensure compliance with regulatory requirements and * optimal animal welfare, our Institutional Animal Care and Use B Gien Program has developed a unique and innovative aspect of the postapproval monitoring program, the postapproval survival surgery Surgery, Envigo, Indianapolis, IN review (PASSR). The IACUC instructs all researchers who conduct survival surgical procedures or who assist with survival surgery (such Using radio frequency identification for electronic study tracking, as monitoring anesthesia and monitoring post-op) to have a PASSR including animals, surgery, dosing, necropsy, data acquisition, and management can improve accuracy, quality, and efficiency during lab 534 Abstracts of scientific papers 2018 AALAS National Meeting animal research.Monitoring test subjects can start before the study acetaminophen once daily via oral gavage. Microsampling and begins. Using programmable RFID microchip technology and software standard sampling were employed and clinical pathology and TK to capture, process, and analyze data, researchers can create a complete profile were compared. Three groups of SD rats were assigned to a 7-d and accurate record for each individual. The tracking can start before repeated dose study. Animal numbers for control and microsampling any dosing begins, as far back as weaning. Using this technology we group was 4 rats/sex/group (n=4) and standard sampling group was were able to track groups of research animals starting with the 8 rats/sex/group (n=8). For microsampling group, approximately implantation of a medical device and vascular catheters until necropsy. 0.15 mL of blood was collected. For the standard sampling group, Monitoring outcomes is an important part of a surgery lab. approximately 0.3 mL of blood was collected by staggered design. TK Documenting and working on improvement, surgery model, time points were conducted at 0, 30 min, 1, 2, 4, 6, 8, and 24 h postdose procedures, or surgeon is key to maintaining the 3Rs. We complete on day 1 and day 7. Clinical pathology was conducted on day 8 at over 60,000 surgeries per year so monitoring quality and efficiency in a endpoint. Although the total collection volume was lower than the paper-based system leaves us with a lot of extra data entry and delays recommended limit, slight anemia including decreases in RBC, HGB, recognition of issues. We looked for an easy-to-use program that could HCT and physiological increases in RDW and reticulocyte were noted monitor individual animal, surgical procedures, surgeon success/ in both standard and microsampling groups caused by repeated blood failure, and surgeon efficiency. Using this new surgery application we collections. This confirmed that the TK animals had different have been able to increase efficiency and monitor and identify surgeon physiological status in hematolgy and should be independent from success and retraining needs. We have been able to provide a complete systemic toxicology evaluation, despite the sampling techniques. TK history of what the animal received for analgesics, anesthetics, and profile was similar in 2 designs. In standard sampling design, samples when they received them. We can also monitor animal checks, when were not collected from the same animals to the next time point and they occurred, and any recurring issues that appear post-surgery. With only 1 TK curve can be generated. In microsampling design, a single all of this data, we have improved training, efficiency, identification of animal provided all-time point samples and single TK curve was surgery issues, and procedural problems. We can also identify highly available. Microsampling provided more information to evaluate the successful surgeons and use them to train our new staff as well as staff individual variation. Microsampling in rats reduced animal numbers, that may be having issues with certain surgeries. study cost, and refined the study design.
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