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ANNUAL REPORT OURINSIDE: 2007 SPRING 2008 Sophie VANDEBROEK CTO, Xerox and President, Xerox Innovation Group Innovation The Issue How Industry Takes Science Outside the Box KIYOSHI KUROKAWA: CREATIVITY AT CORNELL: DAVID EDWARDS ON JAPAN’S INNOVATION DAVID SKORTON & “ARTSCIENCE” ADVOCATE ROBIN DAVISSON Building communities, advancing science since 1817 • www.nyas.org Board of Governors Chair President Vice Chair JOHN E. SEXTON ELLIS RUBINSTEIN BRUCE MCEWEN Treasurer Counsel Secretary MICHAEL SCHMERTZLER VICTORIA BJORKLUND [ex offi cio] LARRY SMITH [ex offi cio] Governors KAREN E. BURKE BRIAN GREENE ABRAHAM LACKMAN VIRGINIA W. CORNISH WILLIAM A. HASELTINE JOHN F. NIBLACK PETER B. CORR STEVEN HOCHBERG ERIC A. ROSE ROBIN L. DAVISSON MORTON HYMAN JEFFREY D. SACHS BRIAN FERGUSON MAREN IMHOFF FRANK WILCZEK JAY FURMAN MADELEINE JACOBS DEBORAH WILEY Honorary Life Governor TORSTEN N. WIESEL President’s Council PETER AGRE, Nobel Laureate & Vice Chancellor for Science and Technology, Duke Univ. RICHARD AXEL, Nobel Laureate & University Professor, Columbia Univ.; Investigator, HHMI LEE BABISS, Vice President, Pre-Clinical Research & Development, Hoffmann La Roche DAVID BALTIMORE, Nobel Laureate & President Emeritus, Caltech ETIENNE-EMILE BAULIEU, former President, French Academy of Sciences ELEANOR BAUM, Dean, School of Engineering, The Cooper Union for the Advancement of Science and Art On the cover: Sophie Vandebroek, PAUL BERG, Nobel Laureate & Professor Emeritus, Dept. of Biochemistry, Stanford Univ. Chief Technology Offi cer, Xerox, and LEN BLAVATNIK, Chairman, Access Industries President of the Xerox Innovation Group GÜNTER BLOBEL, Nobel Laureate & Director, Laboratory for Cell Biology, Rockefeller Univ. PHOTO: COURTESY OF XEROX CHRISTIAN BRECHOT, Director General, INSERM, France SYDNEY BRENNER, Nobel Laureate & Distinguished Prof., Salk Inst. MICHAEL S. BROWN, Nobel Laureate & Prof. of Molecular Genetics, Univ. of Texas Southwestern Medical Center LINDA BUCK, Nobel Laureate & Investigator for HHMI; member of the Fred Hutchinson Cancer Research Center KAREN E. BURKE, Dermatologist & Research Scientist THOMAS R. CECH, Nobel Laureate & President, HHMI CECILA CHAN, Vice Chairman, Immtech Pharmaceuticals, Inc. AARON CIECHANOVER, Nobel Laureate & Distinguished Research Professor, Tumor and Vascular Biology Research Center, Faculty of Medicine, Technion-Israel Inst. of Tech., Haifa, Israel GORDON CONWAY, Chief Science Advisor, UK Department for International Development PETER DOHERTY, Nobel Laureate & Researcher, St. Jude Children’s Research Hospital, Memphis, TN; Univ. of Melbourne FRANK L. DOUGLAS, Executive-in-Residence, MIT Sloan School of Management; former Executive Vice President, Aventis EDMOND H. FISCHER, Nobel Laureate & Professor Emeritus, Department of Biochemistry, Univ. of Washington VICE PRESIDENT, RICHARD N. FOSTER, Millbrook Management Group, LLC PUBLISHING & COMMUNICATIONS CLAIRE M. FRASER-LIGGETT, Director, Univ. of Maryland School of Medicine Bill Silberg ALAN J. FRIEDMAN, former Director, New York Hall of Science JEAN-PIERRE GARNIER, Chief Executive Offi cer, GlaxoSmithKline, UK EXECUTIVE EDITOR COLIN GODDARD, Chief Executive Offi cer, OSI Pharmaceuticals JOSEPH GOLDSTEIN, Nobel Laureate & Chairman, Molecular Genetics, Univ. of Texas Southwestern Medical Center Adrienne J. Burke PAUL GREENGARD, Nobel Laureate & Prof. of Molecular & Cellular Neuroscience, Rockefeller Univ. PETER GRUSS, President, Max Planck Gesellschaft, Germany ASSOCIATE EDITOR WILLIAM A. HASELTINE, President, The Haseltine Foundation for Medical Sciences and the Arts; Leslie Taylor Chairman, Haseltine Global Health, LLC ERIC KANDEL, Nobel Laureate & Prof., Physiology & Cell Biology, Columbia Univ. KIYOSHI KUROKAWA, Science Advisor to the Prime Minister of Japan; Adjunct Professor, RCAST, The Univ. of Tokyo; CREATIVE DIRECTOR Professor, Research Institute of Science and Technology, Tokai Univ. Ayman Shairzay LEON LEDERMAN, Nobel Laureate & Pritzker Prof. of Science, Illinois Inst. of Tech.; Resident Scholar, Illinois Math & Science Academy CONTRIBUTING EDITORS RODERICK MACKINNON, Nobel Laureate & John D. Rockefeller, Jr. Prof., Rockefeller Univ.; Investigator, HHMI Adelle C. Pelekanos, Chris Williams JOEL S. MARCUS, Chief Executive Offi cer, Alexandria Real Estate Equities, Inc. GERALD J. MCDOUGALL, National Partner, Global Pharmaceutical & Health Sciences Practice, PricewaterhouseCoopers LLP RICHARD MENSCHEL, Senior Director, Goldman Sachs EDITORIAL OFFICE RONAY MENSCHEL, Chairman of the Board, Phipps Houses; Board of Overseers, Weill Cornell Medical College 7 World Trade Center JEAN-MARC NEIMETZ, Vice President, Global Life Science Group, Capgemini 250 Greenwich St, 40th Fl JOHN F. NIBLACK, former President, Pfi zer Global Research & Development New York, NY 10007-2157 PAUL NURSE, Nobel Laureate & President, Rockefeller Univ. ROBERT C. RICHARDSON, Nobel Laureate & Senior Vice Provost for Research, Floyd R. Newman Prof. of Physics, Cornell Univ. Phone: 212.298.8655 PETER RINGROSE, Chairman, Biotechnology & Biological Sciences Research Council, UK; former CSO, Bristol-Myers Squibb Fax: 212.298.3665 EDWARD F. ROVER, President, The Dana Foundation Email: [email protected] F. SHERWOOD ROWLAND, Nobel Laureate & Prof. of Chemistry & Earth Science, Univ. of California, Irvine BENGT SAMUELSSON, Nobel Laureate & Prof., Medical & Physiological Chem., Karolinska Inst.; DIRECTOR, MEMBERSHIP former Chairman, The Nobel Foundation CHARLES SANDERS, former President, GlaxoSmithKline David Smith ISMAIL SERAGELDIN, Librarian of Alexandria, Director of the Bibliotheca Alexandria, The Library of Alexandria, Egypt PHILLIP A. SHARP, Nobel Laureate & Director, The McGovern Inst., MIT Center for Cancer Research MEMBERSHIP & ANNALS ORDERS ELLIOTT SIGAL, Chief Scientifi c Offi cer, Bristol-Myers Squibb Phone: 212.298.8640 MICHAEL SOHLMAN, Executive Director, The Nobel Foundation Fax: 212.298.3650 PAUL STOFFELS, Company Group Chairman, World Wide Research & Development, Pharmaceuticals Group, Johnson & Johnson MARY ANN TIGHE, Chief Executive Offi cer, New York Tri-State Region, CB Richard Ellis Email: [email protected] SHIRLEY TILGHMAN, President, Princeton Univ. HAROLD VARMUS, Nobel Laureate & President & CEO, Memorial Sloan-Kettering Cancer Center MANAGER, ADVERTISING SALES FRANK WALSH, Executive Vice President, Discovery Research, Wyeth Karen Crawford GERALD WEISSMANN, Prof. of Medicine, NY Univ. School of Medicine Phone: 212.298.8628 JOHN WHITEHEAD, former Chairman, Lower Manhattan Development Corp.; former Co-Chairman of Goldman Sachs GEORGE WHITESIDES, Mallinckrodt Prof. of Chemistry, Harvard Univ. Email: [email protected] TORSTEN N. WIESEL, Nobel Laureate & Honorary Life Governor, The New York Academy of Sciences; Secretary General, Human Frontier Science Program Organization; President Emeritus, Rockefeller Univ. Visit the Academy online FRANK WILCZEK, Nobel Laureate & Herman Feshbach Professor of Physics, MIT www.nyas.org ERNST-LUDWIG WINNACKER, Secretary General, European Research Council; former President, Deutsche Forschungsgemeinschaft, Germany GUANGZHAO ZHOU, former Chairman, Chinese Association of Science & Technology 1122 1133 2211 YEAR of RENEWAL CContentsonteSpringn 2008 ts 2 INNOVATION: THE RALLYING CRY 12 THE INNOVATION ADVOCATE OF THE 21ST CENTURY by Leslie Taylor by Ellis Rubinstein An interview with Japan’s science advisor, A letter from the president of the Academy Kiyoshi Kurokawa 3 MEMBER NEWS 13 MEMBER MEMOIR: Awards, appointments, and announcements about INGREDIENTS FOR INNOVATION Academy members by David Skorton and Robin Davisson, as told to Adrienne Burke 4 INSIDE THE ACADEMY Cornell’s president and his wife, a biomedical sciences Reports from the directors of Academy programs professor at the university, share views and haiku and news about Academy activities 5 EVENTS GALLERY 14 COVER STORY: HOW INDUSTRY Images captured at recent Academy events TAKES SCIENCE OUTSIDE THE BOX by Leslie Taylor & Adrienne Burke 6 ANNALS OF THE ACADEMY Industry strategies for enabling innovation Featured volumes of the Annals of the New York Academy of Sciences 18 ACADEMY CALENDAR 7 eBRIEFINGS: LATEST DEVELOPMENTS IN NYAS conferences and meetings in April, May, and June SPINAL CORD INJURY RESEARCH AND OTHER REPORTS 21 THE 2007 ANNUAL REPORT OF edited by Chris Williams THE NEW YORK ACADEMY OF SCIENCES Summaries of recent Academy eBriefi ngs 10 BOOK REPORT: CREATIVITY AFTER GOOGLE CORRECTION: Th ere was an error in a byline on p. 8 in by Adelle C. Pelekanos the Winter 2008 edition of the magazine. Alan Dove was David Edwards explores innovation at the intersection of the author of the eBriefi ng “Mitochondria and Oxidative science and art Stress in Neurodegenerative Disorders.” Letter from the President InnovationThe Rallying Cry of the 21st Century n late February, Mexico City Mayor Marcelo Ebrard’s age the keys to economic sustainability for urban centers will be newly appointed Commissioner for Strategic Planning, education, science, technology, fi nance, and a system that stimu- Jorge de los Santos, signed a $750,000 alliance with Th e lates entrepreneurship. Urban centers whose researchers and INew York Academy of Sciences to co-develop his Capital City’s university administrations remain “siloed”—disconnected from fi rst-ever Science & Innovation Week. one another, from industry, and from venture capital—will fall A few months earlier, the New York State Commission on behind. Th e achievement of excellence solely through the global Higher Education recommended a