TABLE S4 Statistically significant variations between ATC-DU-145 and RCO.1

Gene ID n Description of up-regulated known genes C.R. Gene ID n Description of down regulated known genes C.R. OL U70312 3 EGF-like repeats and discoidinI-like domains 12.50 cD 322051 3 Parathyroid hormone 0.62 OL AJ132306 4 HSA132306 MRP2 gene, exon 23"" 12.32 OL M76125 3 AXL receptor tyrosine kinase 0.57 cD 376184 4 Insulin-like growth factor binding protein 3 6.88 OL V00594 3 Metallothionein 2 A 0.56 OL M38591 4 S100 calcium-binding protein A10 5.79 cD 153067 3 Stannio calcin 2 0.55 cD 308366 3 Folate receptor 1 5.13 OL X53587 3 Integrin, beta 4 0.54 OL J02763 4 S100 calcium-binding protein A6 4.65 OL U88573 3 NBR2 0.53 OL X60484 3 H4 histone family, member E 4.37 OL NM_016147 3 Protein phosphatase methylesterase-1 0.53 OL U05598 4 Aldo-keto reductase family 1, member C2 4.27 OL AB032261 4 Stearoyl-CoAdesaturase 4.07 OL AF061738 3 Leucine amino peptidase 0.51 OL U28369 3 Sema domain, immunoglobulin domain 3B 3.90 OL D50840 3 UDP-glucoseceramideglucosyltransferase 0.51 OL M30704 4 Amphiregulin 3.35 cD 712518 4 PMS1 0.50 cD 203721 4 Glutamate cysteine ligase , catalytic 3.01 cD 469931 3 Transcriptional activation factor TAF II32 0.50 OL M76231 3 Sepiapterin reductase 2.96 OL M10943 4 Metallothionein1F 0.49 OL X05908 4 Annexin A 1 2.82 OL AF079167 3 Oxidised low density lipoprotein--receptor-1 0.48 OL NM_016300 3 Cyclic AMP-regulated phosphoprotein, 21 kD 2.78 OL S72043 3 Metallothionein3 0.48 OL AF300649 4 Homo sapiens regulator of G-protein signaling 2.73 OL X65607 4 Metallothionein1X 0.48 OL L19779 3 H2A histone family, member O 2.70 OL M10942 3 Metallothionein 1 E 0.46 OL X03674 3 Glucose-6-phosphatedehydrogenase 2.65 OL L20320 3 Cyclin-dependent kinase 7 0.44 OL U49248 3 ATP-binding cassette, member C2 2.62 OL M13485 4 Metallothionein 1 B 0.44 cD 427768 3 Actin depolymerizing factor 2.61 OL X83703 4 Cardiac ankyrin repeat protein 0.43 OL S79432 4 Gamma-glutamylcysteine synthetase heavy 2.54 OL NM_007192 3 Chromatin-specific transcription elongation factor 0.43 cD 248589 4 Putative serine/threonine protein kinase 2.53 OL U67963 4 Lysophospholipase-like 0.42 OL M35878 4 Insulin-likegrowthfactorbindingprotein3 2.50 cD 840567 4 Tumor Associated Antigen 6 0.40 cD 347573 3 Transcription factor COUP 2 2.50 OL X76717 3 Metallothionein 1 L 0.39 OL X86428 4 Protein phosphatase 2A, regulatory subunit B` 2.47 cD 280768 4 Tumor Associated Antigen 6 0.39 OL U17077 3 BENE protein 2.39 OL Y11307 3 Cysteine-rich, angiogenic inducer, 61 0.36 cD 132304 4 Contactin 1 2.37 OL U57721 3 Kynureninase 2.34 OL X04741 3 Ubiquitin carboxyl-terminal esterase L1 0.35 OL NM_023945 3 Membrane-spanning 4-domains, subfam. A 2.33 cD 110503 4 Fos Related Antigen 1 0.35 cD 208950 4 Microsomal aldehyde dehydrogenase 2.33 cD 484963 4 Metallothionein from cadmium treated cells 0.33 OL NM_014183 3 HSPC162protein 2.29 OL M24283 3 Intercellular adhesion, human rhinovirus receptor 0.32 OL AL031659 3 Ribophorin II 2.27 OL M90657 4 Transmembrane 4 super family member 1 0.32 OL AF091395 3 Triple functional domain 2.26 OL S52784 3 Cystathionase 0.31 cD 47458 3 Thioredoxin reductase 2.25 cD 328692 4 Interleukin 8 0.26 OL U30255 4 Phospho-gluconate-dehydrogenase 2.24 OL AJ270993 4 Homeobox B6 0.25 cD 488974 4 Defender against cell death 2.23 OL M59807 3 Natural killer cell transcript 4 0.25 cD 297595 4 Protein tyrosine phosphatase PTPCAAX1 2.22 OL X16172 4 Human HOX-2.5 gene for homeodomain protein 0.17 OL M92383 3 Homo sapiens thymosin beta-10 gene, 3`end 2.20 cD 136235 4 Glutathione-S-transferase-Pi 0.12 cD 362059 3 Laminin related protein 2.19 OL U12472 4 Glutathione-S-transferase-Pi 0.03 OL Z37986 3 Emopamil-bindingprotein 2.15 cD 180520 4 E6 associated protein E6 AP/ubiquitin ligase 2.15 OL M17733 3 Thymosin, beta 4, X chromosome 2.12 OL U14391 4 MyosinIC 2.09 Gene ID Description (unknown genes or pseudogenes) C.R. OL X01630 3 Arginino succinate synthetase 2.08 OL M63138 3 Cathepsin D 2.07 OL AL122056 3 HomosapiensmRNA;cDNADKFZp434P088 4.28 cD 512246 4 Thymosin B10 2.06 OL AL133645 4 HomosapiensmRNA;cDNADKFZp434C107 3.65 cD 471763 3 Crystallin zeta 2.05 OL NM_025174 4 HypotheticalproteinFLJ23040 3.56 OL S65738 4 Destrin 2.02 OL AL117643 3 HomosapiensmRNA;cDNADKFZp434M245 2.99 OL AF204271 4 Scan domain protein 1 ;SCAN-relatedproteinRAZ1 2.00 OL AC004030 3 Homo sapiens DNA from chromosome 19 2.93 cD 487407 4 Insulin induced protein1 1.99 OL AL022163 3 Farnesyl pyrophosphate synthetase pseudogene 2.91 OL AF019083 3 Phosphatase and tensin homolog , pseudogene 1 1.98 OL AL031903 3 Pseudogene similar to Keratin 18, EST 2.81 OL X57129 4 H1 histone family, member 2 1.97 cD 241972 3 ESTs, Highly similar to COMPL. FACTOR B 2.78 OL Y00486 4 Adenine phosphoribosyl-transferase 1.94 OL M59499 3 Tissue factor pathway inhibitor 2.57 cD 162772 4 Early growth response protein 1 1.94 OL AB007946 3 KIAA0477geneproduct 2.36 OL AL117612 4 Homo sapiens mRNA ; cDNADKFZp564B1264 1.93 cD 83524 3 ESTs, Highly similar to cytochrome P450 IVF3 2.16 OL L13286 3 Cytochrome P450, subfamily XXIV 1.91 OL D15057 4 Defender against cell death 1 1.91 OL NM_024741 3 HypotheticalproteinFLJ12827 2.08 OL M30142 4 Decay accelerating factor for complement 1.91 cD 415014 4 ESTs, Highly similar to THIOREDOXIN 2.05 OL NM_016085 4 Apoptosis related protein APR-3 1.88 OL AC003989 3 HumanBACcloneRG007J15from7q31 2.03 OL U34962 3 Cardiac-specific homeo box 1.88 OL NM_024548 4 HypotheticalproteinFLJ23047 2.02 cD 183945 4 SmallnuclearribonucleoproteinpolypeptideN 1.88 OL AK000575 4 hypotheticalproteinFLJ20568 1.97 OL S54005 3 Thymosin, beta 10 1.87 OL AL117612 4 Homo sapiens mRNA ; cDNADKFZp564B1264 1.90 cD 280069 4 Adrenodoxin Reductase 1.85 OL AK001362 3 Homo sapiens cDNA FLJ10500 fis, 1.80 OL Z80780 4 H2B histone family, member H 1.84 OL AK000174 3 Homo sapiens cDNA FLJ20167 fis, 0.55 OL M74542 4 Aldehyde dehydrogenase 3 1.83 OL L17131 4 High-mobilitygroupproteinisoformsIandY 0.55 OL U76702 3 follistatin-like3 1.83 OL X64116 4 Poliovirus receptor 0.54 OL X67081 3 H4 histone family, member I 1.83 cD 488849 4 ESTs, Highly similar to Glutathione S transferase Pi 0.48 OL X17025 4 Isopentenyl-diphosphate delta isomerase 1.83 OL X96381 3 Ets variant gene 5 0.48 OL M26252 3 Pyruvate kinase, muscle 1.83 cD 563312 3 ESTs, Highly similar to 47 KD Heat shock 0.44 OL D38583 3 S100 calcium-binding protein A11 1.83 cD 546875 3 ESTs, Highly similar to Homeobox protein HOX A6 0.43 OL D89667 4 Prefoldin 5 1.82 OL AK000743 4 hypotheticalproteinFLJ20736 0.43 OL AF137030 4 Transmembrane protein 2 1.82 OL NM_024854 3 HypotheticalproteinFLJ22028 0.42 OL AJ271802 3 Prostaglandin E synthase 1.81 OL AK000507 4 hypotheticalprotein 0.38 cD 310800 4 Decay accelerating factor for complement 1.80 OL NM_024687 4 HypotheticalproteinFLJ23049 0.36 OL Z83738 4 H2B histone family, member E 1.79 OL AK002107 3 Homo sapiens cDNA FLJ11245 fis, 0.24 OL U20982 3 Insulin-likegrowthfactor-bindingprotein4 1.79 OL Z80781 3 H2B histone family, member J 1.75 OL L19185 3 Thioredoxin-dependent peroxide reductase 1 1.72 OL U92436 3 Phosphatase and tensin homolog 1.65 OL L02320 3 Radixin 1.59