Supplementary Table 1

Home , ACADSB, ACADVL, Aldehyde dehydrogenase, BCS1L, Biphenyl synthase, Carboxylate reductase

SUPPLEMENTARY DATA

Supplementary Table 1. Mitochondrial and autophagy-focused post hoc analysis of islet cDNA expression microarrays from WT and Pdx1+/- mice.

FC (Pdx1+/- NAME DESCRIPTION /Pdx1+/+) FDR Ndufs2 NADH dehydrogenase (ubiquinone) Fe-S protein 2 -1.769 5.48 Hspb7 heat shock protein family, member 7 (cardiovascular) -1.744 0 Got2 glutamate oxaloacetate transaminase 2, mitochondrial -1.695 26.38 Dhrs4 dehydrogenase/reductase (SDR family) member 4 -1.602 6.33 methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate Mthfd2 cyclohydrolase -1.597 20.72 Clec16a C-type lectin domain family 16, member A; KIAA0350 -1.583 6.33 Mrpl2 mitochondrial ribosomal protein L2 -1.487 40.08 Tomm20 translocase of outer mitochondrial membrane 20 homolog (yeast) -1.483 40.08 Hadh hydroxyacyl-Coenzyme A dehydrogenase -1.46 18.15 Pcx pyruvate carboxylase -1.448 7.18 Aldh1l2 aldehyde dehydrogenase 1 family, member L2 -1.434 5.48 Sars seryl-aminoacyl-tRNA synthetase -1.429 12.79 Rexo2 REX2, RNA exonuclease 2 homolog (S. cerevisiae) -1.427 40.08 Sars seryl-aminoacyl-tRNA synthetase -1.402 14.73 Bnip3l BCL2/adenovirus E1B interacting protein 3-like -1.398 31.02 Map1lc3b microtubule-associated protein 1 light chain 3 beta -1.394 31.02 Them2 thioesterase superfamily member 2 -1.389 8.77 Elac2 elaC homolog 2 (E. coli) -1.381 7.18 Pcx pyruvate carboxylase -1.377 8.77 Opa1 optic atrophy 1 homolog (human) -1.376 41.46 Acsl5 acyl-CoA synthetase long-chain family member 5 -1.375 41.46 Mrpl12 mitochondrial ribosomal protein L12 -1.363 31.02 Mrps24 mitochondrial ribosomal protein S24 -1.351 40.08 Aldh1b1 aldehyde dehydrogenase 1 family, member B1 -1.348 41.46 Vdac2 voltage-dependent anion channel 2 -1.334 41.46 Cox6c cytochrome c oxidase, subunit VIc -1.324 35.06 Brp44l brain protein 44-like -1.32 5.48 Hadh hydroxyacyl-Coenzyme A dehydrogenase -1.32 26.38 Cyb5r1 cytochrome b5 reductase 1 -1.314 41.46 2610524G07Rik RIKEN cDNA 2610524G07 gene -1.312 41.46 Gcat glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase) -1.309 41.46 Sars seryl-aminoacyl-tRNA synthetase -1.307 12.79 Acsm2 acyl-CoA synthetase medium-chain family member 2 -1.301 26.38 Vdac1 voltage-dependent anion channel 1 -1.301 41.46 Mrpl39 mitochondrial ribosomal protein L39 -1.295 5.48 Yars2 tyrosyl-tRNA synthetase 2 (mitochondrial) -1.274 7.18 Comt catechol-O-methyltransferase -1.272 20.72 Phb2 prohibitin 2 -1.268 35.06 Nme3 expressed in non-metastatic cells 3 -1.265 11.31 methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate Mthfd1 cyclohydrolase, formyltetrahydrofolate synthase -1.263 18.15 Mtch1 mitochondrial carrier homolog 1 (C. elegans) -1.259 7.18 Mrpl2 mitochondrial ribosomal protein L2 -1.257 40.08 Tdh L-threonine dehydrogenase -1.256 41.46 Nme3 expressed in non-metastatic cells 3 -1.254 11.31 Cox6a1 cytochrome c oxidase, subunit VI a, polypeptide 1 -1.253 20.72 Crot carnitine O-octanoyltransferase -1.245 40.08 Gfm2 G elongation factor, mitochondrial 2 -1.244 41.46

Pdss1 prenyl (solanesyl) diphosphate synthase, subunit 1 -1.244 41.46 Nt5c3 5'-nucleotidase, cytosolic III -1.242 20.72 Akr1b7 aldo-keto reductase family 1, member B7 -1.238 31.02 2310056P07Rik RIKEN cDNA 2310056P07 gene -1.234 41.46 Nt5c3 5'-nucleotidase, cytosolic III -1.226 7.18 Pitrm1 pitrilysin metallepetidase 1 -1.226 5.48 Gpx4 glutathione peroxidase 4 -1.223 5.48 Gpd2 glycerol phosphate dehydrogenase 2, mitochondrial -1.221 20.72 Mrps25 mitochondrial ribosomal protein S25 -1.221 48.24 Me3 malic enzyme 3, NADP(+)-dependent, mitochondrial -1.215 43.77 0610009O20Rik RIKEN cDNA 0610009O20 gene -1.213 48.24 Maoa monoamine oxidase A -1.213 43.77 Fth1 ferritin heavy chain 1 -1.212 18.15 Nme3 expressed in non-metastatic cells 3 -1.21 12.79 4432406C05Rik RIKEN cDNA 4432406C05 gene -1.209 41.46 Acadl acyl-Coenzyme A dehydrogenase, long-chain -1.207 43.77 Mrps26 mitochondrial ribosomal protein S26 -1.207 26.38 Acadm acyl-Coenzyme A dehydrogenase, medium chain -1.203 48.24 Hadh hydroxyacyl-Coenzyme A dehydrogenase -1.203 43.77 Fh1 fumarate hydratase 1 -1.193 43.77 2610524G07Rik RIKEN cDNA 2610524G07 gene -1.191 31.02 Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 -1.191 41.46 Rdh14 retinol dehydrogenase 14 (all-trans and 9-cis) -1.189 35.06 Sqrdl sulfide quinone reductase-like (yeast) -1.189 11.31 Park7 Parkinson disease (autosomal recessive, early onset) 7 -1.188 31.02 Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -1.187 43.77 0610006I08Rik RIKEN cDNA 0610006I08 gene -1.186 40.08 Bax Bcl2-associated X protein -1.183 41.46 Cox5a cytochrome c oxidase, subunit Va -1.179 41.46 Mrps18b mitochondrial ribosomal protein S18B -1.177 31.02 A830073O21Rik RIKEN cDNA A830073O21 gene -1.174 48.24 methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate Mthfd1 cyclohydrolase, formyltetrahydrofolate synthase -1.174 12.79 Ldha lactate dehydrogenase A -1.17 40.08 Ldha lactate dehydrogenase A -1.168 31.02 H2-Ke6 H2-K region expressed gene 6 -1.167 40.08 Mrpl12 mitochondrial ribosomal protein L12 -1.167 20.72 Ndufab1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1 -1.167 26.38 Chchd4 coiled-coil-helix-coiled-coil-helix domain containing 4 -1.166 41.46 Triap1 TP53 regulated inhibitor of apoptosis 1 -1.164 40.08 Usmg5 upregulated during skeletal muscle growth 5 -1.164 41.46 Acaa1b acetyl-Coenzyme A acyltransferase 1B -1.163 8.77 Oxnad1 oxidoreductase NAD-binding domain containing 1 -1.163 41.46 Mrps7 mitchondrial ribosomal protein S7 -1.162 43.77 Cox7a2l cytochrome c oxidase subunit VIIa polypeptide 2-like -1.158 11.31 Hbld2 HESB like domain containing 2 -1.158 41.46 Slc25a25 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 -1.157 41.46 Ndufb4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4 -1.154 40.08 Mtch1 mitochondrial carrier homolog 1 (C. elegans) -1.152 41.46 Gpx1 glutathione peroxidase 1 -1.151 41.46 Mrpl30 mitochondrial ribosomal protein L30 -1.151 40.08 2310056P07Rik RIKEN cDNA 2310056P07 gene -1.149 48.24 Crls1 cardiolipin synthase 1 -1.149 35.06 Hagh hydroxyacyl glutathione hydrolase -1.149 41.46

Nme2 expressed in non-metastatic cells 2, protein -1.149 41.46 Hagh hydroxyacyl glutathione hydrolase -1.148 40.08 Mrpl46 mitochondrial ribosomal protein L46 -1.148 26.38 Rab1b RAB1B, member RAS oncogene family -1.144 40.08 Gbas glioblastoma amplified sequence -1.143 40.08 Tfam transcription factor A, mitochondrial -1.143 41.46 0710008K08Rik RIKEN cDNA 0710008K08 gene -1.142 41.46 2010107E04Rik RIKEN cDNA 2010107E04 gene -1.142 40.08 Auh AU RNA binding protein/enoyl-coenzyme A hydratase -1.142 43.77 Cry1 cryptochrome 1 (photolyase-like) -1.142 48.24 Ndufb9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9 -1.142 40.08 Ldha lactate dehydrogenase A -1.14 41.46 Tdh L-threonine dehydrogenase -1.14 43.77 1110001J03Rik RIKEN cDNA 1110001J03 gene -1.138 26.38 Cox7a2l cytochrome c oxidase subunit VIIa polypeptide 2-like -1.138 26.38 Rab1b RAB1B, member RAS oncogene family -1.138 40.08 Rhoa ras homolog gene family, member A -1.138 41.46 Zadh2 zinc binding alcohol dehydrogenase, domain containing 2 -1.136 35.06 Pnkd paroxysmal nonkinesiogenic dyskinesia -1.135 41.46 Brp44 brain protein 44 -1.133 48.24 Hint2 histidine triad nucleotide binding protein 2 -1.133 41.46 Mrrf mitochondrial ribosome recycling factor -1.133 35.06 Ndufa7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a) -1.133 41.46 Atpif1 ATPase inhibitory factor 1 -1.131 43.77 C1qbp complement component 1, q subcomponent binding protein -1.131 40.08 Guf1 GUF1 GTPase homolog (S. cerevisiae) -1.131 40.08 Idh3b isocitrate dehydrogenase 3 (NAD+) beta -1.131 26.38 Ndufa12l Ndufa12-like -1.131 41.46 Ndufs6 NADH dehydrogenase (ubiquinone) Fe-S protein 6 -1.13 20.72 Slc25a4 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 -1.129 43.77 Gpx1 glutathione peroxidase 1 -1.128 41.46 2010107E04Rik RIKEN cDNA 2010107E04 gene -1.125 41.46 Tspo translocator protein -1.124 43.77 Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 -1.122 58.28 Hagh hydroxyacyl glutathione hydrolase -1.121 41.46 1110007M04Rik RIKEN cDNA 1110007M04 gene -1.12 43.77 mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor Magmas signal transduction -1.12 40.08 Ndufa3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3 -1.12 41.46 Rps14 ribosomal protein S14 -1.119 40.08 C1qbp complement component 1, q subcomponent binding protein -1.118 41.46 Auh AU RNA binding protein/enoyl-coenzyme A hydratase -1.117 35.06 Ict1 immature colon carcinoma transcript 1 -1.117 41.46 Nudt19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 -1.117 43.77 Rab11b RAB11B, member RAS oncogene family -1.117 48.24 Cox7a2 cytochrome c oxidase, subunit VIIa 2 -1.115 40.08 Ndufb5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5 -1.115 40.08 Rab8b RAB8B, member RAS oncogene family -1.114 41.46 Yme1l1 YME1-like 1 (S. cerevisiae) -1.114 35.06 Nfxl1 nuclear transcription factor, X-box binding-like 1 -1.113 41.46 Rab8b RAB8B, member RAS oncogene family -1.113 41.46 Tomm20 translocase of outer mitochondrial membrane 20 homolog (yeast) -1.113 40.08 Mcart1 mitochondrial carrier triple repeat 1 -1.112 41.46 Mrpl15 mitochondrial ribosomal protein L15 -1.112 43.77

Sccpdh saccharopine dehydrogenase (putative) -1.112 43.77 A230051G13Rik RIKEN cDNA A230051G13 gene -1.11 35.06 Mrpl51 mitochondrial ribosomal protein L51 -1.11 41.46 0710008K08Rik RIKEN cDNA 0710008K08 gene -1.109 40.08 Serhl serine hydrolase-like -1.108 43.77 Sfxn1 sideroflexin 1 -1.108 40.08 Gcsh glycine cleavage system protein H (aminomethyl carrier) -1.107 41.46 Uqcr ubiquinol-cytochrome c reductase (6.4kD) subunit -1.106 41.46 Spryd4 SPRY domain containing 4 -1.104 41.46 Mrpl23 mitochondrial ribosomal protein L23 -1.103 41.46 Mrpl36 mitochondrial ribosomal protein L36 -1.103 41.46 Rab24 RAB24, member RAS oncogene family -1.103 41.46 9330129D05Rik RIKEN cDNA 9330129D05 gene -1.102 41.46 Sod2 superoxide dismutase 2, mitochondrial -1.102 41.46 Clybl citrate lyase beta like -1.101 41.46 1500032L24Rik RIKEN cDNA 1500032L24 gene -1.1 41.46 Idh1 isocitrate dehydrogenase 1 (NADP+), soluble -1.1 48.24 Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -1.1 58.28 Spryd4 SPRY domain containing 4 -1.1 41.46 Them2 thioesterase superfamily member 2 -1.1 40.08 Ghitm growth hormone inducible transmembrane protein -1.099 41.46 Mrpl2 mitochondrial ribosomal protein L2 -1.099 41.46 Mrpl33 mitochondrial ribosomal protein L33 -1.099 41.46 Timm13 translocase of inner mitochondrial membrane 13 homolog (yeast) -1.099 35.06 Chchd3 coiled-coil-helix-coiled-coil-helix domain containing 3 -1.098 41.46 D2Bwg1335e DNA segment, Chr 2, Brigham & Women's Genetics 1335 expressed -1.098 41.46 Mpv17 Mpv17 transgene, kidney disease mutant -1.097 43.77 Pccb propionyl Coenzyme A carboxylase, beta polypeptide -1.097 41.46 Pigy phosphatidylinositol glycan anchor biosynthesis, class Y -1.097 40.08 Vamp8 vesicle-associated membrane protein 8 -1.097 40.08 Lamp2 lysosomal membrane glycoprotein 2 -1.095 41.46 Timm9 translocase of inner mitochondrial membrane 9 homolog (yeast) -1.095 41.46 Tomm20 translocase of outer mitochondrial membrane 20 homolog (yeast) -1.095 48.24 Gabarapl2 gamma-aminobutyric acid (GABA-A) receptor-associated protein-like 2 -1.094 41.46 1500032D16Rik RIKEN cDNA 1500032D16 gene -1.093 41.46 Dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) -1.093 40.08 Prodh2 proline dehydrogenase (oxidase) 2 -1.093 43.77 Dhrs1 dehydrogenase/reductase (SDR family) member 1 -1.091 43.77 2700085E05Rik RIKEN cDNA 2700085E05 gene -1.09 41.46 Dap3 death associated protein 3 -1.09 41.46 Dmgdh dimethylglycine dehydrogenase precursor -1.09 41.46 2010100O12Rik RIKEN cDNA 2010100O12 gene -1.089 43.77 Cox7b cytochrome c oxidase subunit VIIb -1.088 41.46 Mrpl20 mitochondrial ribosomal protein L20 -1.088 41.46 Acaa2 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) -1.086 43.77 Hspe1 heat shock protein 1 (chaperonin 10) -1.086 48.24 1110008F13Rik RIKEN cDNA 1110008F13 gene -1.084 43.77 Mrps15 mitochondrial ribosomal protein S15 -1.084 41.46 Aldh2 aldehyde dehydrogenase 2, mitochondrial -1.083 53.11 Mrpl53 mitochondrial ribosomal protein L53 -1.083 43.77 Rps14 ribosomal protein S14 -1.083 40.08 Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 -1.083 43.77 Ncoa4 nuclear receptor coactivator 4 -1.081 48.24

Apoa1bp apolipoprotein A-I binding protein -1.08 41.46 Bckdha branched chain ketoacid dehydrogenase E1, alpha polypeptide -1.08 48.24 Slc25a39 solute carrier family 25, member 39 -1.08 43.77 Slc25a5 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 -1.08 43.77 Rnmtl1 RNA methyltransferase like 1 -1.079 40.08 Tmem11 transmembrane protein 11 -1.079 43.77 Bckdha branched chain ketoacid dehydrogenase E1, alpha polypeptide -1.078 48.24 Fkbp8 FK506 binding protein 8 -1.078 48.24 Map1lc3b microtubule-associated protein 1 light chain 3 beta -1.078 43.77 Mars2 methionine-tRNA synthetase 2 (mitochondrial) -1.078 43.77 Mfn2 mitofusin 2 -1.078 41.46 Ndufb2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2 -1.078 53.11 Cox6b1 cytochrome c oxidase, subunit VIb polypeptide 1 -1.077 48.24 Hk2 hexokinase 2 -1.077 43.77 Ncoa4 nuclear receptor coactivator 4 -1.077 48.24 Timm50 translocase of inner mitochondrial membrane 50 homolog (yeast) -1.077 41.46 Atp5j ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F -1.076 43.77 Aldh1b1 aldehyde dehydrogenase 1 family, member B1 -1.075 43.77 Cyb5b cytochrome b5 type B -1.075 41.46 Mrps14 mitochondrial ribosomal protein S14 -1.075 41.46 Mtch1 mitochondrial carrier homolog 1 (C. elegans) -1.075 48.24 Ndufs7 NADH dehydrogenase (ubiquinone) Fe-S protein 7 -1.075 43.77 Pptc7 PTC7 protein phosphatase homolog (S. cerevisiae) -1.075 41.46 Bckdha branched chain ketoacid dehydrogenase E1, alpha polypeptide -1.074 53.11 Lamp2 lysosomal membrane glycoprotein 2 -1.074 43.77 Mrps22 mitochondrial ribosomal protein S22 -1.074 43.77 Tsfm Ts translation elongation factor, mitochondrial -1.074 43.77 1810035L17Rik RIKEN cDNA 1810035L17 gene -1.073 41.46 2010100O12Rik RIKEN cDNA 2010100O12 gene -1.073 43.77 Dut deoxyuridine triphosphatase -1.073 41.46 Hspe1 heat shock protein 1 (chaperonin 10) -1.073 53.11 Pnpt1 polyribonucleotide nucleotidyltransferase 1 -1.073 48.24 Cox7b cytochrome c oxidase subunit VIIb -1.072 48.24 Glrx5 glutaredoxin 5 homolog (S. cerevisiae) -1.072 48.24 Ccdc90b coiled-coil domain containing 90B -1.071 43.77 Mrps18a mitochondrial ribosomal protein S18A -1.071 48.24 Cbara1 calcium binding atopy-related autoantigen 1 -1.07 43.77 Coq5 coenzyme Q5 homolog, methyltransferase (yeast) -1.07 43.77 Guf1 GUF1 GTPase homolog (S. cerevisiae) -1.07 43.77 Slc25a28 solute carrier family 25, member 28 -1.07 41.46 Timm23 translocase of inner mitochondrial membrane 23 homolog (yeast) -1.07 43.77 Cox7b cytochrome c oxidase subunit VIIb -1.069 48.24 Rfk riboflavin kinase -1.068 48.24 Aldh18a1 aldehyde dehydrogenase 18 family, member A1 -1.067 48.24 Clpb ClpB caseinolytic peptidase B homolog (E. coli) -1.067 43.77 Cs citrate synthase -1.067 43.77 Gabarap gamma-aminobutyric acid receptor associated protein -1.067 48.24 Idh3b isocitrate dehydrogenase 3 (NAD+) beta -1.067 43.77 Sfxn5 sideroflexin 5 -1.067 53.11 Tomm7 translocase of outer mitochondrial membrane 7 homolog (yeast) -1.067 43.77 Bnip3l BCL2/adenovirus E1B interacting protein 3-like -1.067 41.46 Atg7 autophagy-related 7 (yeast) -1.066 41.46 Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -1.066 43.77

Letmd1 LETM1 domain containing 1 -1.064 41.46 Mrpl38 mitochondrial ribosomal protein L38 -1.064 43.77 Mrps21 mitochondrial ribosomal protein S21 -1.064 43.77 Mthfs 5, 10-methenyltetrahydrofolate synthetase -1.064 43.77 Ndufb11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11 -1.064 43.77 Timm23 translocase of inner mitochondrial membrane 23 homolog (yeast) -1.064 48.24 Wars2 tryptophanyl tRNA synthetase 2 (mitochondrial) -1.064 58.28 1500032D16Rik RIKEN cDNA 1500032D16 gene -1.063 43.77 1700021F05Rik RIKEN cDNA 1700021F05 gene -1.063 48.24 Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -1.063 48.24 Aurkaip1 aurora kinase A interacting protein 1 -1.062 48.24 Gars glycyl-tRNA synthetase -1.061 53.11 Phb2 prohibitin 2 -1.061 48.24 Pnpt1 polyribonucleotide nucleotidyltransferase 1 -1.061 48.24 Slc25a1 solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1 -1.061 43.77 Mrpl41 mitochondrial ribosomal protein L41 -1.06 48.24 Ndufa4 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4 -1.06 43.77 Aco2 aconitase 2, mitochondrial -1.059 43.77 Mrpl39 mitochondrial ribosomal protein L39 -1.059 58.28 Acadsb acyl-Coenzyme A dehydrogenase, short/branched chain -1.058 43.77 Coq3 coenzyme Q3 homolog, methyltransferase (yeast) -1.058 43.77 Cox7c cytochrome c oxidase, subunit VIIc -1.058 41.46 Krt5 keratin 5 -1.058 48.24 Nars asparaginyl-tRNA synthetase -1.058 58.28 Ncoa4 nuclear receptor coactivator 4 -1.058 53.11 Ndufa13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 -1.058 43.77 Pnkd paroxysmal nonkinesiogenic dyskinesia -1.058 48.24 Tomm70a translocase of outer mitochondrial membrane 70 homolog A (yeast) -1.058 48.24 Aldh18a1 aldehyde dehydrogenase 18 family, member A1 -1.057 48.24 Cox7b cytochrome c oxidase subunit VIIb -1.057 53.11 Mtfr1 mitochondrial fission regulator 1 -1.057 53.11 BC051227 cDNA sequence BC051227 -1.056 58.28 Htra2 HtrA serine peptidase 2 -1.056 48.24 Idh1 isocitrate dehydrogenase 1 (NADP+), soluble -1.056 43.77 Idh3a isocitrate dehydrogenase 3 (NAD+) alpha -1.056 48.24 Nudt19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 -1.056 48.24 Slc25a19 solute carrier family 25 (mitochondrial deoxynucleotide carrier), member 19 -1.056 43.77 Mrpl43 mitochondrial ribosomal protein L43 -1.055 48.24 Ndufb8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 8 -1.055 53.11 Tfam transcription factor A, mitochondrial -1.055 41.46 Timm50 translocase of inner mitochondrial membrane 50 homolog (yeast) -1.055 43.77 Bad Bcl-associated death promoter -1.054 48.24 Hk2 hexokinase 2 -1.054 48.24 Oxct1 3-oxoacid CoA transferase 1 -1.054 43.77 Slc25a3 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 -1.054 53.11 Tbrg4 transforming growth factor beta regulated gene 4 -1.054 48.24 Nnt nicotinamide nucleotide transhydrogenase -1.053 53.11 Sdhb succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -1.053 48.24 Scp2 sterol carrier protein 2, liver -1.051 48.24 Tfam transcription factor A, mitochondrial -1.051 43.77 2310042G06Rik RIKEN cDNA 2310042G06 gene -1.05 43.77 Efha1 EF hand domain family A1 -1.05 43.77 Ndufa7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a) -1.05 48.24

Ndufb5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5 -1.05 48.24 Sdhb succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -1.05 48.24 Mrps5 mitochondrial ribosomal protein S5 -1.049 53.11 B230118G17Rik RIKEN cDNA B230118G17 gene -1.048 58.28 Bloc1s1 biogenesis of lysosome-related organelles complex-1, subunit 1 -1.048 58.28 Gyk glycerol kinase -1.048 43.77 Ndufab1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1 -1.048 48.24 Uqcrb ubiquinol-cytochrome c reductase binding protein -1.048 53.11 Acaca acetyl-Coenzyme A carboxylase alpha -1.047 43.77 Phyhipl phytanoyl-CoA hydroxylase interacting protein-like -1.047 43.77 Atp5h ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d -1.046 53.11 Decr1 2,4-dienoyl CoA reductase 1, mitochondrial -1.046 53.11 Cyb5b cytochrome b5 type B -1.045 48.24 Lonp1 lon peptidase 1, mitochondrial -1.045 43.77 Ndufa11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 11 -1.045 53.11 Phb prohibitin -1.045 48.24 Tmem70 transmembrane protein 70 -1.045 43.77 2810037C14Rik RIKEN cDNA 2810037C14 gene -1.044 48.24 Hao3 hydroxyacid oxidase (glycolate oxidase) 3 -1.044 43.77 Mrps34 mitochondrial ribosomal protein S34 -1.044 53.11 Pink1 PTEN induced putative kinase 1 -1.044 58.28 C330021A05Rik RIKEN cDNA C330021A05 gene -1.043 43.77 Acss1 acyl-CoA synthetase short-chain family member 1 -1.042 43.77 Atp5o ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit -1.042 63.99 Efha1 EF hand domain family A1 -1.042 48.24 Mrpl51 mitochondrial ribosomal protein L51 -1.042 58.28 Scp2 sterol carrier protein 2, liver -1.042 53.11 Tufm Tu translation elongation factor, mitochondrial -1.042 53.11 Mrpl50 mitochondrial ribosomal protein L50 -1.041 48.24 Qdpr quinoid dihydropteridine reductase -1.041 48.24 Tomm40 translocase of outer mitochondrial membrane 40 homolog (yeast) -1.041 43.77 Acat1 acetyl-Coenzyme A acetyltransferase 1 -1.04 58.28 Alas1 aminolevulinic acid synthase 1 -1.04 53.11 Ech1 enoyl coenzyme A hydratase 1, peroxisomal -1.04 63.99 Mosc2 MOCO sulphurase C-terminal domain containing 2 -1.04 53.11 Tatdn3 TatD DNase domain containing 3 -1.04 53.11 Drg2 developmentally regulated GTP binding protein 2 -1.039 53.11 Etfa electron transferring flavoprotein, alpha polypeptide -1.039 53.11 Sirt3 sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae) -1.039 53.11 BC021611 cDNA sequence BC021611 -1.038 53.11 Cycs cytochrome c, somatic -1.038 48.24 Sdhb succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -1.038 48.24 Atp5j2 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f, isoform 2 -1.037 63.99 Eefsec eukaryotic elongation factor, selenocysteine-tRNA-specific -1.037 58.28 Fis1 fission 1 (mitochondrial outer membrane) homolog (yeast) -1.037 53.11 Lamp2 lysosomal membrane glycoprotein 2 -1.037 53.11 Map1lc3b microtubule-associated protein 1 light chain 3 beta -1.037 58.28 Ndufb10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10 -1.037 53.11 Parl presenilin associated, rhomboid-like -1.037 43.77 Yme1l1 YME1-like 1 (S. cerevisiae) -1.037 58.28 Atg12 autophagy-related 12 (yeast) -1.036 53.11 Atp5o ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit -1.036 53.11 Chchd1 coiled-coil-helix-coiled-coil-helix domain containing 1 -1.036 53.11

Ndufs3 NADH dehydrogenase (ubiquinone) Fe-S protein 3 -1.036 53.11 Rab11b RAB11B, member RAS oncogene family -1.036 58.28 Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 -1.036 63.99 Acaca acetyl-Coenzyme A carboxylase alpha -1.035 48.24 Aldh4a1 aldehyde dehydrogenase 4 family, member A1 -1.035 48.24 Ech1 enoyl coenzyme A hydratase 1, peroxisomal -1.035 63.99 Nfs1 nitrogen fixation gene 1 (S. cerevisiae) -1.035 53.11 Abcf2 ATP-binding cassette, sub-family F (GCN20), member 2 -1.034 58.28 Cyb5r1 cytochrome b5 reductase 1 -1.034 48.24 Maoa monoamine oxidase A -1.034 58.28 Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase -1.033 48.24 Mtch2 mitochondrial carrier homolog 2 (C. elegans) -1.033 58.28 1500032D16Rik RIKEN cDNA 1500032D16 gene -1.032 58.28 Atp5g3 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 3 -1.032 63.99 Atp5k ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit e -1.032 58.28 Bak1 BCL2-antagonist/killer 1 -1.032 48.24 C1qbp complement component 1, q subcomponent binding protein -1.032 48.24 Dcakd dephospho-CoA kinase domain containing -1.032 63.99 Gpam glycerol-3-phosphate acyltransferase, mitochondrial -1.032 53.11 Mrpl27 mitochondrial ribosomal protein L27 -1.032 53.11 Mrpl47 mitochondrial ribosomal protein L47 -1.032 58.28 Mrpl49 mitochondrial ribosomal protein L49 -1.032 63.99 Mrps24 mitochondrial ribosomal protein S24 -1.032 58.28 Ndufv2 NADH dehydrogenase (ubiquinone) flavoprotein 2 -1.032 58.28 Slc30a6 solute carrier family 30 (zinc transporter), member 6 -1.032 53.11 Tomm40 translocase of outer mitochondrial membrane 40 homolog (yeast) -1.032 53.11 Vars2l valyl-tRNA synthetase 2-like -1.032 48.24 Fastkd2 FAST kinase domains 2 -1.031 63.99 Qdpr quinoid dihydropteridine reductase -1.031 53.11 4432406C05Rik RIKEN cDNA 4432406C05 gene -1.03 58.28 Etfa electron transferring flavoprotein, alpha polypeptide -1.03 58.28 Oxct1 3-oxoacid CoA transferase 1 -1.03 58.28 Rhot1 ras homolog gene family, member T1 -1.03 58.28 Rhot2 ras homolog gene family, member T2 -1.03 48.24 Slc25a14 solute carrier family 25 (mitochondrial carrier, brain), member 14 -1.03 63.99 Uqcrh ubiquinol-cytochrome c reductase hinge protein -1.03 53.11 Cbr4 carbonyl reductase 4 -1.029 53.11 Mrpl15 mitochondrial ribosomal protein L15 -1.029 58.28 Pycr1 pyrroline-5-carboxylate reductase 1 -1.029 58.28 Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 -1.028 53.11 Fastk Fas-activated serine/threonine kinase -1.027 58.28 Hmgcl 3-hydroxy-3-methylglutaryl-Coenzyme A lyase -1.027 63.99 Map1lc3a microtubule-associated protein 1 light chain 3 alpha -1.027 53.11 Pccb propionyl Coenzyme A carboxylase, beta polypeptide -1.027 63.99 Poldip2 polymerase (DNA-directed), delta interacting protein 2 -1.027 58.28 Rab4b RAB4B, member RAS oncogene family -1.027 63.99 Uxs1 UDP-glucuronate decarboxylase 1 -1.027 53.11 Gng5 guanine nucleotide binding protein (G protein), gamma 5 subunit -1.026 63.99 Gtpbp5 GTP binding protein 5 -1.026 53.11 Slc25a5 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 -1.026 58.28 Adck2 aarF domain containing kinase 2 -1.025 58.28 Ccbl2 cysteine conjugate-beta lyase 2 -1.025 58.28 Clybl citrate lyase beta like -1.025 53.11

Cox7b cytochrome c oxidase subunit VIIb -1.025 58.28 Efha1 EF hand domain family A1 -1.025 63.99 Glrx2 glutaredoxin 2 (thioltransferase) -1.025 63.99 Rarsl arginyl-tRNA synthetase-like -1.025 63.99 Sptlc2 serine palmitoyltransferase, long chain base subunit 2 -1.025 63.99 Sardh sarcosine dehydrogenase -1.024 63.99 Atp5a1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1 -1.023 68.12 Ddah1 dimethylarginine dimethylaminohydrolase 1 -1.023 68.12 Mpv17l Mpv17 transgene, kidney disease mutant-like -1.023 53.11 Timm44 translocase of inner mitochondrial membrane 44 -1.023 58.28 Trap1 TNF receptor-associated protein 1 -1.023 53.11 Acly ATP citrate lyase -1.022 63.99 Bcl2l13 BCL2-like 13 (apoptosis facilitator) -1.022 53.11 Cox7b cytochrome c oxidase subunit VIIb -1.022 63.99 Mtx2 metaxin 2 -1.022 63.99 Oxr1 oxidation resistance 1 -1.022 63.99 Txn2 thioredoxin 2 -1.022 58.28 1700034H14Rik RIKEN cDNA 1700034H14 gene -1.021 63.99 Aldh7a1 aldehyde dehydrogenase family 7, member A1 -1.021 63.99 Fth1 ferritin heavy chain 1 -1.021 63.99 Rab4b RAB4B, member RAS oncogene family -1.021 63.99 5033414D02Rik RIKEN cDNA 5033414D02 gene -1.02 58.28 Abhd10 abhydrolase domain containing 10 -1.02 63.99 Bckdk branched chain ketoacid dehydrogenase kinase -1.02 68.12 Dap3 death associated protein 3 -1.02 63.99 Hibch 3-hydroxyisobutyryl-Coenzyme A hydrolase -1.02 68.12 Ptges2 prostaglandin E synthase 2 -1.02 58.28 Rab8b RAB8B, member RAS oncogene family -1.02 58.28 Tomm70a translocase of outer mitochondrial membrane 70 homolog A (yeast) -1.02 63.99 Bcs1l BCS1-like (yeast) -1.019 63.99 Prdx3 peroxiredoxin 3 -1.019 58.28 Immt inner membrane protein, mitochondrial -1.018 68.12 Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 -1.017 63.99 Mrpl24 mitochondrial ribosomal protein L24 -1.017 68.12 Hmgcl 3-hydroxy-3-methylglutaryl-Coenzyme A lyase -1.016 68.12 Lactb2 lactamase, beta 2 -1.016 63.99 Pmpca peptidase (mitochondrial processing) alpha -1.016 63.99 Sod2 superoxide dismutase 2, mitochondrial -1.016 68.12 Stoml2 stomatin (Epb7.2)-like 2 -1.016 68.12 Bnip3l BCL2/adenovirus E1B interacting protein 3-like -1.015 70.81 Cct7 chaperonin subunit 7 (eta) -1.015 63.99 Phb prohibitin -1.015 68.12 Pmpcb peptidase (mitochondrial processing) beta -1.015 68.12 As3mt arsenic (+3 oxidation state) methyltransferase -1.014 68.12 Mrpl17 mitochondrial ribosomal protein L17 -1.014 68.12 Rhoa ras homolog gene family, member A -1.014 70.81 Rnf41 ring finger protein 41 -1.014 68.12 1110002E23Rik RIKEN cDNA 1110002E23 gene -1.013 68.12 Ak2 adenylate kinase 2 -1.013 63.99 Clic4 chloride intracellular channel 4 (mitochondrial) -1.013 68.12 Hagh hydroxyacyl glutathione hydrolase -1.013 70.81 Mrpl1 mitochondrial ribosomal protein L1 -1.013 63.99 Ndufb5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5 -1.013 68.12

Ppa2 pyrophosphatase (inorganic) 2 -1.013 63.99 Zcd1 zinc finger, CDGSH-type domain 1 -1.013 68.12 Chchd2 coiled-coil-helix-coiled-coil-helix domain containing 2 -1.012 63.99 Shmt1 serine hydroxymethyl transferase 1 (soluble) -1.012 68.12 0610009O20Rik RIKEN cDNA 0610009O20 gene -1.011 68.12 Aco2 aconitase 2, mitochondrial -1.011 68.12 Ndufab1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1 -1.011 68.12 Timm17a translocase of inner mitochondrial membrane 17a -1.011 68.12 Uqcrb ubiquinol-cytochrome c reductase binding protein -1.011 70.81 Acad9 acyl-Coenzyme A dehydrogenase family, member 9 -1.01 68.12 Alas1 aminolevulinic acid synthase 1 -1.01 68.12 Atp5l ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g -1.01 70.81 Pmpca peptidase (mitochondrial processing) alpha -1.01 68.12 Prdx2 peroxiredoxin 2 -1.01 70.81 Slc25a46 solute carrier family 25, member 46 -1.01 68.12 Uqcrc2 ubiquinol cytochrome c reductase core protein 2 -1.01 68.12 4933403F05Rik RIKEN cDNA 4933403F05 gene -1.009 68.12 Mrpl10 mitochondrial ribosomal protein L10 -1.009 70.81 Mrps11 mitochondrial ribosomal protein S11 -1.009 70.81 Nipsnap1 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (C. elegans) -1.009 70.81 Vdac2 voltage-dependent anion channel 2 -1.009 70.81 Adck4 aarF domain containing kinase 4 -1.008 68.12 Aldh7a1 aldehyde dehydrogenase family 7, member A1 -1.008 70.81 Etfa electron transferring flavoprotein, alpha polypeptide -1.008 70.81 Hsdl1 hydroxysteroid dehydrogenase like 1 -1.008 68.12 Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -1.008 68.12 Mpv17 Mpv17 transgene, kidney disease mutant -1.008 70.81 Cs citrate synthase -1.007 70.81 Hsd3b4 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4 -1.007 70.81 Mrpl47 mitochondrial ribosomal protein L47 -1.007 70.81 Tarsl1 threonyl-tRNA synthetase-like 1 -1.007 68.12 Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) -1.007 70.81 Mtch2 mitochondrial carrier homolog 2 (C. elegans) -1.006 70.81 Acads acyl-Coenzyme A dehydrogenase, short chain -1.005 70.81 Sdhd succinate dehydrogenase complex, subunit D, integral membrane protein -1.005 70.81 Pdk2 pyruvate dehydrogenase kinase, isoenzyme 2 -1.004 72.23 Pigy phosphatidylinositol glycan anchor biosynthesis, class Y -1.004 72.23 Acly ATP citrate lyase -1.003 72.23 Bax Bcl2-associated X protein -1.003 72.23 C330018D20Rik RIKEN cDNA C330018D20 gene -1.003 70.81 D10Jhu81e DNA segment, Chr 10, Johns Hopkins University 81 expressed -1.003 70.81 Fahd1 fumarylacetoacetate hydrolase domain containing 1 -1.003 72.23 Mrpl1 mitochondrial ribosomal protein L1 -1.003 72.23 Coq2 coenzyme Q2 homolog, prenyltransferase (yeast) -1.002 72.23 Mrpl52 mitochondrial ribosomal protein L52 -1.002 72.23 Sod1 superoxide dismutase 1, soluble -1.002 72.23 Aldh2 aldehyde dehydrogenase 2, mitochondrial -1.001 72.23 Atp5a1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1 -1.001 72.23 Atp5g3 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 3 -1.001 72.23 Bcat2 branched chain aminotransferase 2, mitochondrial -1.001 72.23 Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 -1.001 72.23 Tfb2m transcription factor B2, mitochondrial -1.001 72.23 Bcl2 B-cell leukemia/lymphoma 2 1 73.48

Sdhc succinate dehydrogenase complex, subunit C, integral membrane protein 1 72.23 Aco2 aconitase 2, mitochondrial 1.001 73.48 Cyc1 cytochrome c-1 1.001 73.48 Hmgcl 3-hydroxy-3-methylglutaryl-Coenzyme A lyase 1.001 73.48 Mterfd1 MTERF domain containing 1 1.001 73.48 Ndufs1 NADH dehydrogenase (ubiquinone) Fe-S protein 1 1.001 73.48 Hspa9 heat shock protein 9 1.002 73.48 Pycr1 pyrroline-5-carboxylate reductase 1 1.002 73.48 Rab11a RAB11a, member RAS oncogene family 1.002 73.48 1110002E23Rik RIKEN cDNA 1110002E23 gene 1.003 73.48 Guf1 GUF1 GTPase homolog (S. cerevisiae) 1.003 73.48 Idh3b isocitrate dehydrogenase 3 (NAD+) beta 1.003 73.48 methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate Mthfd2 cyclohydrolase 1.003 68.12 5033414D02Rik RIKEN cDNA 5033414D02 gene 1.004 73.38 Atp5g2 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 2 1.004 73.48 Atp5j2 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f, isoform 2 1.004 73.48 Atp5j2 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f, isoform 2 1.004 73.48 Acsm3 acyl-CoA synthetase medium-chain family member 3 1.005 73.48 Eln elastin 1.005 73.48 Uqcrc2 ubiquinol cytochrome c reductase core protein 2 1.005 73.38 1110007M04Rik RIKEN cDNA 1110007M04 gene 1.006 73.48 Adsl adenylosuccinate lyase 1 1.006 73.38 Ak2 adenylate kinase 2 1.006 73.07 Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 1.006 73.38 Etfa electron transferring flavoprotein, alpha polypeptide 1.006 73.48 Nars2 asparaginyl-tRNA synthetase 2 (mitochondrial)(putative) 1.006 73.48 Nme2 expressed in non-metastatic cells 2, protein 1.006 73.38 Prdx6 peroxiredoxin 6 1.006 73.48 Prodh2 proline dehydrogenase (oxidase) 2 1.006 73.38 Bdh1 3-hydroxybutyrate dehydrogenase, type 1 1.007 73.07 Pdss2 prenyl (solanesyl) diphosphate synthase, subunit 2 1.007 73.38 A830073O21Rik RIKEN cDNA A830073O21 gene 1.008 73.38 Dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) 1.008 73.48 Sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 1.008 73.38 Comt catechol-O-methyltransferase 1.009 73.07 Fxc1 fractured callus expressed transcript 1 1.009 72.23 Ndufs1 NADH dehydrogenase (ubiquinone) Fe-S protein 1 1.009 72.23 Tomm20 translocase of outer mitochondrial membrane 20 homolog (yeast) 1.009 73.07 1100001I22Rik RIKEN cDNA 1100001I22 gene 1.01 70.81 Chchd2 coiled-coil-helix-coiled-coil-helix domain containing 2 1.01 72.23 Fdxr ferredoxin reductase 1.01 72.23 Mrpl33 mitochondrial ribosomal protein L33 1.01 72.23 Ndufb7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7 1.01 73.07 Ndufv1 NADH dehydrogenase (ubiquinone) flavoprotein 1 1.01 72.23 Nfxl1 nuclear transcription factor, X-box binding-like 1 1.01 72.23 Nudt13 nudix (nucleoside diphosphate linked moiety X)-type motif 13 1.01 73.07 Rpl10a ribosomal protein L10A 1.01 73.07 Acsl1 acyl-CoA synthetase long-chain family member 1 1.011 73.07 Atpbd3 ATP binding domain 3 1.011 72.23 Atp5c1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 1.012 72.23 Mpst mercaptopyruvate sulfurtransferase 1.012 72.23 Mrps31 mitochondrial ribosomal protein S31 1.012 70.81 Acadm acyl-Coenzyme A dehydrogenase, medium chain 1.013 72.23

Gls2 glutaminase 2 (liver, mitochondrial) 1.013 70.81 Pex11b peroxisomal biogenesis factor 11b 1.013 73.07 Tst thiosulfate sulfurtransferase, mitochondrial 1.013 72.23 Tufm Tu translation elongation factor, mitochondrial 1.013 70.81 Nit1 nitrilase 1 1.014 70.81 Qrsl1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 1.014 70.81 Suclg1 succinate-CoA ligase, GDP-forming, alpha subunit 1.014 70.81 Glrx2 glutaredoxin 2 (thioltransferase) 1.015 72.23 Ivd isovaleryl coenzyme A dehydrogenase 1.015 70.81 Kars lysyl-tRNA synthetase 1.015 70.81 Mrpl37 mitochondrial ribosomal protein L37 1.015 68.12 Sfxn5 sideroflexin 5 1.015 68.12 9430016H08Rik RIKEN cDNA 9430016H08 gene 1.017 68.12 Abcd3 ATP-binding cassette, sub-family D (ALD), member 3 1.017 72.23 Atp5c1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 1.017 72.23 Gfm1 G elongation factor, mitochondrial 1 1.017 70.81 Ndufs3 NADH dehydrogenase (ubiquinone) Fe-S protein 3 1.017 72.23 Opa1 optic atrophy 1 homolog (human) 1.017 72.23 Ppa2 pyrophosphatase (inorganic) 2 1.017 70.81 Slc25a26 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26 1.017 72.23 Uvrag UV radiation resistance associated gene 1.017 68.12 Mrpl38 mitochondrial ribosomal protein L38 1.018 70.81 Rpl10a ribosomal protein L10A 1.018 72.23 Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) 1.018 70.81 Chchd7 coiled-coil-helix-coiled-coil-helix domain containing 7 1.02 70.81 Eln elastin 1.02 72.23 Fxc1 fractured callus expressed transcript 1 1.02 70.81 Ndufs3 NADH dehydrogenase (ubiquinone) Fe-S protein 3 1.02 68.12 Ndufs4 NADH dehydrogenase (ubiquinone) Fe-S protein 4 1.02 70.81 1810020G14Rik RIKEN cDNA 1810020G14 gene 1.021 70.81 Becn1 beclin 1 (coiled-coil, myosin-like BCL2-interacting protein) 1.021 70.81 Mrpl38 mitochondrial ribosomal protein L38 1.021 68.12 Pcca propionyl-Coenzyme A carboxylase, alpha polypeptide 1.021 68.12 Sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 1.021 70.81 Slc25a37 solute carrier family 25, member 37 1.021 70.81 Abcb6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 1.022 68.12 Acad9 acyl-Coenzyme A dehydrogenase family, member 9 1.022 63.99 Cox8a cytochrome c oxidase, subunit VIIIa 1.022 68.12 Idh3g isocitrate dehydrogenase 3 (NAD+), gamma 1.022 68.12 Mdh2 malate dehydrogenase 2, NAD (mitochondrial) 1.022 72.23 Nme2 expressed in non-metastatic cells 2, protein 1.022 63.99 Rb1cc1 RB1-inducible coiled-coil 1 1.022 68.12 Uvrag UV radiation resistance associated gene 1.022 70.81 Bcs1l BCS1-like (yeast) 1.023 68.12 Ak3 adenylate kinase 3 1.024 63.99 Prdx5 peroxiredoxin 5 1.024 70.81 Gls glutaminase 1.025 70.81 Pisd phosphatidylserine decarboxylase 1.025 63.99 Dld dihydrolipoamide dehydrogenase 1.027 72.23 Ndufv1 NADH dehydrogenase (ubiquinone) flavoprotein 1 1.027 63.99 Pank2 pantothenate kinase 2 (Hallervorden-Spatz syndrome) 1.027 63.99 Rab11a RAB11a, member RAS oncogene family 1.027 70.81 Rab35 RAB35, member RAS oncogene family 1.027 68.12

Rhoa ras homolog gene family, member A 1.027 70.81 Ndufa2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2 1.028 70.81 Vdac3 voltage-dependent anion channel 3 1.029 63.99 4930402E16Rik RIKEN cDNA 4930402E16 gene 1.03 68.12 Abhd11 abhydrolase domain containing 11 1.03 68.12 Ak3 adenylate kinase 3 1.03 70.81 Iars2 isoleucine-tRNA synthetase 2, mitochondrial 1.03 63.99 Mrps2 mitochondrial ribosomal protein S2 1.03 63.99 Ndufa12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 1.03 63.99 Prdx2 peroxiredoxin 2 1.03 63.99 Rdh13 retinol dehydrogenase 13 (all-trans and 9-cis) 1.03 70.81 Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 1.03 68.12 Wars2 tryptophanyl tRNA synthetase 2 (mitochondrial) 1.03 63.99 Atp5o ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit 1.031 63.99 Phyhipl phytanoyl-CoA hydroxylase interacting protein-like 1.031 63.99 Acad8 acyl-Coenzyme A dehydrogenase family, member 8 1.032 63.99 Cox7b cytochrome c oxidase subunit VIIb 1.032 68.12 Mmab methylmalonic aciduria (cobalamin deficiency) type B homolog (human) 1.032 63.99 Parl presenilin associated, rhomboid-like 1.032 68.12 Slc25a36 solute carrier family 25, member 36 1.032 68.12 Suclg2 succinate-Coenzyme A ligase, GDP-forming, beta subunit 1.032 63.99 Echs1 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial 1.033 63.99 Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 1.033 63.99 Peo1 progressive external ophthalmoplegia 1 (human) 1.033 63.99 Prdx6 peroxiredoxin 6 1.033 68.12 Sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 1.033 68.12 Suclg1 succinate-CoA ligase, GDP-forming, alpha subunit 1.033 68.12 Tufm Tu translation elongation factor, mitochondrial 1.033 70.81 Ddx28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 1.034 68.12 Qdpr quinoid dihydropteridine reductase 1.034 58.28 Wipi2 WD repeat domain, phosphoinositide interacting 2 1.034 68.12 Dcakd dephospho-CoA kinase domain containing 1.035 68.12 Nnt nicotinamide nucleotide transhydrogenase 1.035 68.12 Rab11b RAB11B, member RAS oncogene family 1.035 63.99 Shmt1 serine hydroxymethyl transferase 1 (soluble) 1.035 58.28 Sirt3 sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae) 1.035 58.28 Fech ferrochelatase 1.036 58.28 Nt5m 5',3'-nucleotidase, mitochondrial 1.036 68.12 2410003P15Rik RIKEN cDNA 2410003P15 gene 1.037 68.12 Aco1 aconitase 1 1.037 58.28 Fdps farnesyl diphosphate synthetase 1.037 72.23 Mrpl44 mitochondrial ribosomal protein L44 1.037 63.99 Ndg2 Nur77 downstream gene 2 1.039 58.28 Pdk1 pyruvate dehydrogenase kinase, isoenzyme 1 1.039 63.99 Yme1l1 YME1-like 1 (S. cerevisiae) 1.039 70.81 Bax Bcl2-associated X protein 1.04 58.28 Hadh hydroxyacyl-Coenzyme A dehydrogenase 1.04 53.11 Mtif2 mitochondrial translational initiation factor 2 1.04 63.99 Tspo translocator protein 1.041 70.81 Vdac3 voltage-dependent anion channel 3 1.041 58.28 2310061I04Rik RIKEN cDNA 2310061I04 gene 1.042 58.28 Prdx6 peroxiredoxin 6 1.042 68.12 Sdhc succinate dehydrogenase complex, subunit C, integral membrane protein 1.042 63.99

Sod2 superoxide dismutase 2, mitochondrial 1.042 63.99 Mrpl44 mitochondrial ribosomal protein L44 1.043 58.28 Nfu1 NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae) 1.043 58.28 Suclg2 succinate-Coenzyme A ligase, GDP-forming, beta subunit 1.043 58.28 0610038F07Rik RIKEN cDNA 0610038F07 gene 1.044 68.12 Fkbp8 FK506 binding protein 8 1.044 63.99 Ivd isovaleryl coenzyme A dehydrogenase 1.044 63.99 Tomm20 translocase of outer mitochondrial membrane 20 homolog (yeast) 1.044 70.81 Echs1 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial 1.047 63.99 Mrpl15 mitochondrial ribosomal protein L15 1.047 63.99 Ireb2 iron responsive element binding protein 2 1.048 70.81 Opa1 optic atrophy 1 homolog (human) 1.048 63.99 Mrps12 mitochondrial ribosomal protein S12 1.049 58.28 1700020C11Rik RIKEN cDNA 1700020C11 gene 1.05 58.28 Ndufab1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1 1.051 58.28 Rab8b RAB8B, member RAS oncogene family 1.051 58.28 Got2 glutamate oxaloacetate transaminase 2, mitochondrial 1.052 63.99 Abcb10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 1.053 58.28 Mat2b methionine adenosyltransferase II, beta 1.054 53.11 Slc25a23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 1.054 58.28 Acaa1b acetyl-Coenzyme A acyltransferase 1B 1.056 53.11 Gpx4 glutathione peroxidase 4 1.056 63.99 Opa1 optic atrophy 1 homolog (human) 1.056 63.99 BC021611 cDNA sequence BC021611 1.057 48.24 Slc25a22 solute carrier family 25 (mitochondrial carrier, glutamate), member 22 1.057 58.28 Slc25a3 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 1.057 63.99 Sptlc2 serine palmitoyltransferase, long chain base subunit 2 1.057 53.11 Atad3a ATPase family, AAA domain containing 3A 1.058 58.28 Bckdk branched chain ketoacid dehydrogenase kinase 1.058 58.28 Dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) 1.058 63.99 Mrpl13 mitochondrial ribosomal protein L13 1.058 53.11 Wipi2 WD repeat domain, phosphoinositide interacting 2 1.058 58.28 Ivd isovaleryl coenzyme A dehydrogenase 1.059 63.99 Samm50 sorting and assembly machinery component 50 homolog (S. cerevisiae) 1.059 53.11 AF397014 cDNA sequence AF397014 1.06 58.28 Fasn fatty acid synthase 1.061 48.24 Rg9mtd1 RNA (guanine-9-) methyltransferase domain containing 1 1.061 53.11 4432406C05Rik RIKEN cDNA 4432406C05 gene 1.062 53.11 5730469M10Rik RIKEN cDNA 5730469M10 gene 1.063 58.28 Atp5b ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit 1.063 53.11 Uqcrb ubiquinol-cytochrome c reductase binding protein 1.063 48.24 Nipsnap1 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (C. elegans) 1.064 63.99 Atp5g1 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 1 1.065 48.24 Bckdk branched chain ketoacid dehydrogenase kinase 1.065 53.11 Usp8 ubiquitin specific peptidase 8 1.065 53.11 Aldh9a1 aldehyde dehydrogenase 9, subfamily A1 1.066 58.28 Rab3d RAB3D, member RAS oncogene family 1.066 58.28 Acadvl acyl-Coenzyme A dehydrogenase, very long chain 1.067 43.77 Aco1 aconitase 1 1.067 43.77 Adck2 aarF domain containing kinase 2 1.067 53.11 Agxt2l2 alanine-glyoxylate aminotransferase 2-like 2 1.067 58.28 Atp5a1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1 1.068 58.28 Elac2 elaC homolog 2 (E. coli) 1.068 53.11

Pet112l PET112-like (yeast) 1.069 48.24 Cox5b cytochrome c oxidase, subunit Vb 1.07 53.11 Krt5 keratin 5 1.07 48.24 Pcca propionyl-Coenzyme A carboxylase, alpha polypeptide 1.07 48.24 Ak2 adenylate kinase 2 1.071 58.28 Bcat2 branched chain aminotransferase 2, mitochondrial 1.073 53.11 Ccdc90a coiled-coil domain containing 90A 1.073 53.11 Nfxl1 nuclear transcription factor, X-box binding-like 1 1.073 68.12 Prdx6 peroxiredoxin 6 1.073 58.28 Timm50 translocase of inner mitochondrial membrane 50 homolog (yeast) 1.073 48.24 Nrd1 nardilysin, N-arginine dibasic convertase, NRD convertase 1 1.074 58.28 Nrd1 nardilysin, N-arginine dibasic convertase, NRD convertase 1 1.074 63.99 8430406I07Rik RIKEN cDNA 8430406I07 gene 1.075 63.99 Atp5c1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 1.075 48.24 Bphl biphenyl hydrolase-like (serine hydrolase, breast epithelial mucin-associated antigen) 1.075 48.24 Slc25a37 solute carrier family 25, member 37 1.075 68.12 Atp5c1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 1.076 48.24 Mdh1 malate dehydrogenase 1, NAD (soluble) 1.077 58.28 Abcd3 ATP-binding cassette, sub-family D (ALD), member 3 1.078 48.24 Mrpl37 mitochondrial ribosomal protein L37 1.078 43.77 Mrpl44 mitochondrial ribosomal protein L44 1.078 53.11 Rtn4ip1 reticulon 4 interacting protein 1 1.079 48.24 Polg polymerase (DNA directed), gamma 1.08 48.24 Atp5a1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1 1.081 58.28 Hibadh 3-hydroxyisobutyrate dehydrogenase 1.081 58.28 Pdhx pyruvate dehydrogenase complex, component X 1.081 43.77 Acat2 acetyl-Coenzyme A acetyltransferase 2 1.082 48.24 Bphl biphenyl hydrolase-like (serine hydrolase, breast epithelial mucin-associated antigen) 1.082 41.46 Ak2 adenylate kinase 2 1.084 53.11 Dhx29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 1.084 63.99 Gatm glycine amidinotransferase (L-arginine:glycine amidinotransferase) 1.084 58.28 Rpl35a ribosomal protein L35a 1.085 58.28 Yme1l1 YME1-like 1 (S. cerevisiae) 1.085 63.99 Gatm glycine amidinotransferase (L-arginine:glycine amidinotransferase) 1.086 63.99 Msra methionine sulfoxide reductase A 1.086 48.24 Ldhd lactate dehydrogenase D 1.087 43.77 Ptcd3 Pentatricopeptide repeat domain 3 1.087 41.46 Gatm glycine amidinotransferase (L-arginine:glycine amidinotransferase) 1.088 68.12 Mrps27 mitochondrial ribosomal protein S27 1.088 43.77 Mtif2 mitochondrial translational initiation factor 2 1.09 53.11 Hspd1 heat shock protein 1 (chaperonin) 1.091 53.11 Trnt1 tRNA nucleotidyl transferase, CCA-adding, 1 1.091 53.11 Slc25a23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 1.092 43.77 Fasn fatty acid synthase 1.093 48.24 Ttc35 tetratricopeptide repeat domain 35 1.093 48.24 Etfa electron transferring flavoprotein, alpha polypeptide 1.094 43.77 Gsr glutathione reductase 1 1.095 48.24 hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A Hadha hydratase (trifunctional protein), alpha subunit 1.096 41.46 Sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 1.096 58.28 Atp5f1 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b, isoform 1 1.097 58.28 Gatm glycine amidinotransferase (L-arginine:glycine amidinotransferase) 1.097 63.99 Hk2 hexokinase 2 1.097 53.11 Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 1.098 43.77

Fth1 ferritin heavy chain 1 1.098 58.28 Dut deoxyuridine triphosphatase 1.099 43.77 Hrsp12 heat-responsive protein 12 1.103 41.46 Ccdc58 coiled-coil domain containing 58 1.106 31.02 Ogdh oxoglutarate dehydrogenase (lipoamide) 1.106 43.77 Sod1 superoxide dismutase 1, soluble 1.106 43.77 Pex11b peroxisomal biogenesis factor 11b 1.107 43.77 Pnpt1 polyribonucleotide nucleotidyltransferase 1 1.107 48.24 Qdpr quinoid dihydropteridine reductase 1.108 48.24 Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 1.11 48.24 Aco1 aconitase 1 1.112 43.77 Rars arginyl-tRNA synthetase 1.113 53.11 Rps15a ribosomal protein S15a 1.113 48.24 Gfm2 G elongation factor, mitochondrial 2 1.114 43.77 Mod1 malic enzyme, supernatant 1.114 48.24 Ociad1 OCIA domain containing 1 1.114 40.08 1110001J03Rik RIKEN cDNA 1110001J03 gene 1.116 35.06 Mccc2 methylcrotonoyl-Coenzyme A carboxylase 2 (beta) 1.116 26.38 Ndufa9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9 1.117 20.72 Mod1 malic enzyme, supernatant 1.118 40.08 Ndufb7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7 1.118 43.77 Echdc3 enoyl Coenzyme A hydratase domain containing 3 1.119 35.06 Oat ornithine aminotransferase 1.119 53.11 Rexo2 REX2, RNA exonuclease 2 homolog (S. cerevisiae) 1.12 40.08 Cycs cytochrome c, somatic 1.122 48.24 hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A Hadhb hydratase (trifunctional protein), beta subunit 1.122 35.06 Gpx1 glutathione peroxidase 1 1.123 58.28 Nrd1 nardilysin, N-arginine dibasic convertase, NRD convertase 1 1.123 53.11 Pdk3 pyruvate dehydrogenase kinase, isoenzyme 3 1.123 26.38 Txnrd1 thioredoxin reductase 1 1.123 53.11 2310028O11Rik RIKEN cDNA 2310028O11 gene 1.125 18.15 Pdk3 pyruvate dehydrogenase kinase, isoenzyme 3 1.128 41.46 Cycs cytochrome c, somatic 1.129 53.11 Atp5b ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit 1.131 48.24 Foxred1 FAD-dependent oxidoreductase domain containing 1 1.131 41.46 Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 1.131 40.08 Gcdh glutaryl-Coenzyme A dehydrogenase 1.134 31.02 Nme1 expressed in non-metastatic cells 1, protein 1.134 48.24 Atp5a1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1 1.137 53.11 Phyh phytanoyl-CoA hydroxylase 1.138 53.11 Adck2 aarF domain containing kinase 2 1.142 40.08 Hccs holocytochrome c synthetase 1.142 43.77 Prdx6 peroxiredoxin 6 1.144 53.11 Rab32 RAB32, member RAS oncogene family 1.144 63.99 Slc25a20 solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 1.148 41.46 Apex2 apurinic/apyrimidinic endonuclease 2 1.15 20.72 Atpif1 ATPase inhibitory factor 1 1.15 43.77 Txn1 thioredoxin 1 1.151 43.77 Sdhc succinate dehydrogenase complex, subunit C, integral membrane protein 1.152 43.77 Acot2 acyl-CoA thioesterase 2 1.153 43.77 1110001J03Rik RIKEN cDNA 1110001J03 gene 1.154 40.08 Rab11fip5 RAB11 family interacting protein 5 (class I) 1.154 35.06 Cct7 chaperonin subunit 7 (eta) 1.157 35.06

Acadvl acyl-Coenzyme A dehydrogenase, very long chain 1.158 43.77 Ndufc2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2 1.166 48.24 Cpt1a carnitine palmitoyltransferase 1a, liver 1.167 35.06 Tomm20 translocase of outer mitochondrial membrane 20 homolog (yeast) 1.168 48.24 Agpat5 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon) 1.169 40.08 Cct7 chaperonin subunit 7 (eta) 1.179 41.46 Pdha1 pyruvate dehydrogenase E1 alpha 1 1.181 41.46 Pnpt1 polyribonucleotide nucleotidyltransferase 1 1.194 26.38 AL033314 expressed sequence AL033314 1.2 18.15 Spr sepiapterin reductase 1.202 31.02 Suox sulfite oxidase 1.202 31.02 Slc25a3 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 1.205 48.24 Ddah1 dimethylarginine dimethylaminohydrolase 1 1.211 12.79 Gpd1 glycerol-3-phosphate dehydrogenase 1 (soluble) 1.218 48.24 Alas2 aminolevulinic acid synthase 2, erythroid 1.219 53.11 Sfxn5 sideroflexin 5 1.241 8.77 Prdx1 peroxiredoxin 1 1.246 7.18 Ncoa4 nuclear receptor coactivator 4 1.278 8.77 Acp6 acid phosphatase 6, lysophosphatidic 1.28 14.73 Ide insulin degrading enzyme 1.292 35.06 Agxt2 alanine-glyoxylate aminotransferase 2 1.3 31.02 Idi1 isopentenyl-diphosphate delta isomerase 1.347 18.15 Glud1 glutamate dehydrogenase 1 1.358 3.62 Etfb electron transferring flavoprotein, beta polypeptide 1.36 12.79 Lrpprc leucine-rich PPR-motif containing 1.4 4.22 Peci peroxisomal delta3, delta2-enoyl-Coenzyme A isomerase 1.417 7.18 Idi1 isopentenyl-diphosphate delta isomerase 1.418 6.33 Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) 1.455 14.73