Glycoprotein hormones alpha chain Hormone ligand-binding receptors Glycoprotein hormones Mineralocorticoid biosynthesis TFAP2 (AP-2) family regulates transcriptionAndrogenThyroid of biosynthesis growth stimulating factors hormone and their receptor receptors Reactions specificThyroxine to the complex biosynthesis N-glycan synthesis pathway Multidrug resistance-associated proteinGlucagon-like 5 peptide 1 receptor 78 kDa glucose-regulated Hyaluronan biosynthesis and export Glucagon-type ligand receptors Platelet degranulation G alpha (s)ABC-family signalling proteinsevents mediated transport PERKATF6 regulates(ATF6-alpha) activates expression chaperones Guanine nucleotide-binding protein G(s), subunit alpha Regulation of HSF1-mediated heat shock response Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ATF6 (ATF6-alpha)IRE1alpha activates activates chaperone chaperones Parathyroid hormone receptor Serotonin (5-HT)Prostacyclin receptorG alpha signalling (z) signalling through events prostacyclin receptor Ras-related protein Rab-9A G alpha (q) signalling events GlucagonHedgehog signaling 'off' in metabolic state regulation PKA activation in glucagon signalling RAB geranylgeranylation Ubiquitin carboxyl-terminal hydrolase 1 Vasopressin regulates renal water homeostasis via Aquaporins Rap guanine nucleotide exchange factor 3 Class B/2 (Secretin Neuropeptidefamily receptors) S receptor Rap guanine nucleotide exchange factor 4 RetrogradeRAB transportGEFs exchange at the Trans-Golgi-Network GTP for GDP on RABs Serotonin receptorsRegulator of G-protein signaling 4 Fanconi Anemia Pathway Recognition of DNA damage by PCNA-containing replication complex Regulation of insulin secretion Rap1 signalling G alpha (i) signalling events Integrin alphaIIb beta3 signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Galanin receptor 3

Rac GTPase-activating protein 1 Peptide ligand-binding receptors MHC class II antigen presentation Kinesins Alpha-synuclein Rho GTPase cycle Amyloid fiber formation COPI-dependent Golgi-to-ER retrograde traffic Prostaglandin E synthase Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Post-translationalIron uptake modification: and transport synthesis of GPI-anchored Transport of organic anions Inactivation, recoveryParadoxical and regulation activation of the of RAFphototransduction signaling by kinase cascade inactive BRAF Signaling by RAS mutants Solute carrier organic anion transporter family member15-hydroxyprostaglandin 1B3Proton-coupled dehydrogenaseFolate folate receptor transporter [NAD+] beta Solute carrier organic anion transporter family member 1B1 Clathrin-mediatedBeta-arrestin-1 endocytosis Golgi Associated Vesicle Biogenesis Thrombin signallingAminopeptidase through proteinase activated receptors (PARs) Activation of SMO SynthesisArachidonate of 15-eicosatetraenoic 15-lipoxygenase, acid type derivatives II Cargo recognitionLysosome for clathrin-mediated Vesicle Biogenesis endocytosis Recycling of bile acids and salts Signaling by BRAF and RAFMAP2K fusions and MAPK activation Fatty acid synthase Serine hydroxymethyltransferase, cytosolic ActivatedSignaling NOTCH1 by Transmits high-kinase Signal activity to the BRAF Nucleus mutants ChREBP activates metabolic Folate transporter 1 Signaling by moderate kinase activity BRAF mutants Vitamin B5 (pantothenate) metabolism Carnitine synthesis Chemokine receptors bind chemokines UDP-glucuronosyltransferaseGlucuronidation 1-10 ActivationFatty of geneacyl-CoA expression biosynthesis by SREBF (SREBP) Metabolism of folatePrelamin-A/C and pterines EGFR Transactivation by Gastrin Interleukin-10ATF4 signaling activates genes Synthesis of Lipoxins (LX) E3 ubiquitin-protein ligase UHRF1 Assembly of collagen fibrilsCollagen and degradationother multimeric structuresInterleukin-8 DNA methylation XBP1(S)Fructose catabolismactivates chaperone genes Ethanol oxidation Activation of Matrix Metalloproteinases RA biosynthesis pathway MatrixDegradation metalloproteinase of the extracellular (2 and 3) matrix Flap endonucleaseEarly Phase of1 HIV Life Cycle Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterolAldehyde dehydrogenase HDR through MMEJ (alt-NHEJ) Removal of the Flap Intermediate fromCOPII the C-strand(CoatFolate Protein receptor 2) Mediated alpha VesicleBile Transport acid receptor FXR Removal of the Flap Intermediate Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarateEPH-ephrin mediated repulsion of cells Synthesis of bile acids and bile salts Collagenase FCERI mediated NF-kB activation PCNA-Dependent Long Patch Base Excision Repair COPI-mediated anterograde transport NADPH regeneration CLEC7A/inflammasome pathway POLB-Dependent Long Patch Base Excision Repair Cargo concentrationSynthesis in ofthe bile ER acids and bile salts via 27-hydroxycholesterol TAK1 activatesRegulatedTRAF6 NFkB mediated proteolysis by phosphorylation NF-kB of p75NTR activation and activation of IKKs complex Isocitrate dehydrogenase [NADP] cytoplasmic RIP-mediated NFkB activation via ZBP1 DEx/H-boxMAP3K8Downstream (TPL2)-dependent activate TCR signalingtype MAPK1/3 I IFN and activation inflammatory cytokines production Synthesis of LeukotrienesAntigen processing: (LT) and Eoxins Ubiquitination (EX) & Proteasome degradationIKBKG deficiency causes anhidroticCLEC7A ectodermal (Dectin-1) dysplasia signaling with immunodeficiency (EDA-ID) (via TLR) Phase I - Functionalization of compounds NF-kB isCD209 activated (DC-SIGN) Activationand signals signaling of survivalNF-kappaB in B cells DNA-(apurinic or apyrimidinic site) lyase 5-lipoxygenase/FLAP Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Endogenous sterols Synthesis of 5-eicosatetraenoic acids IkBA variant leadsInterleukin-1 to EDA-ID family signaling Resolution of AP sites via the multiple-nucleotide patch replacement pathway Nuclear factor NF-kappa-B complex Interleukin-1 processing Telomere Extension By ResolutionDisplacement of Abasic of DNA Sites glycosylase (AP sites) by APEX1 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway Alpha-galactosidase A Telomerase Sphingomyelin phosphodiesterase Xenobiotics Neutrophil degranulationDownstream signal transduction Post-translationalRHO GTPases activate protein IQGAPs phosphorylation Aryl hydrocarbon receptor STAT6-mediated induction of chemokines Signal transducer and activator ofGlycosphingolipid transcription metabolism 6 PPARA activates gene expression Menin

Niemann-Pick C1 protein Formation of the beta-catenin:TCF transactivating complex LDL clearance RUNX1 regulates transcription of genes involved in differentiation of HSCs Interleukin-4 and 13 signaling PTK6 Expression PTK6 promotes HIF1A stabilization Histone-lysine N-methyltransferase MLL Sodium/nucleoside cotransporter 2 Oxygen-dependent asparagine hydroxylation of Hypoxia-inducibleDeactivation Factorof the beta-catenin Alpha transactivating complex Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Translesion synthesis by POLI Acyl chain remodelling of PI Neddylation Acyl chain remodelling of PE Regulation of geneKeap1/Nrf2 expression by Hypoxia-inducible Factor PhospholipaseAcyl chain A2 remodelling group 1B of PC Hypoxia inducible factors; HIF-1-alpha,Beta-glucocerebrosidase HIF-2-alphaRUNX1 regulates genes involved in megakaryocyte differentiation and platelet function DNA iota Synthesis of PA Acyl chain remodelling of PS Acyl chain remodelling of PG Aryl hydrocarbon receptor signallingNuclear receptor ROR-gammaCREB phosphorylationRecycling pathway through of theL1 activation of Ras NOTCH1 Intracellular Domain Regulates Transcription Dihydrofolate CREBreductase phosphorylation Regulation of lipid metabolismCircadianp75NTR byHDACsClock Peroxisome negatively deacetylate proliferator-activatedregulates histones cell cycle via receptor SC1 alpha (PPARalpha) ERK/MAPK targets BMAL1:CLOCK,NPAS2Constitutive activatesRORA circadianactivatesSignaling genebygene NOTCH1 expression expression HD+PEST DomainPKMTs methylateMutants histone lysines Gastrin-CREB signalling pathway via PKC and MAPK TranscriptionalConstitutive SignalingRUNX3activation regulates by of NOTCH1mitochondrial p14-ARF PEST biogenesis Domain Mutants RibosomalRSK activation protein S6 kinase alpha 3 NoRCNR1D1 negatively (REV-ERBA) regulatesRepression represses rRNATranscription of geneWNT expression expression target of E2F genestargets under negative control by DREAM complex DNA topoisomerase II Cilium Assembly Gap-fillingTranslesion DNA repair synthesis synthesis by and POLK ligation in TC-NER Gap-filling DNA repair synthesisTermination and ligation of translesion in GG-NER DNA synthesis ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Dual Incision in GG-NER Dual incision in TC-NER Thyroid hormone receptor SMAD2/SMAD3:SMAD4Histone deacetylase heterotrimer regulates transcription CDT1 association with the CDC6:ORC:origin complex RNA Polymerase I Transcription Initiation DNA polymerase kappa VLDLR internalisationLXR-beta and degradation Removal ofGeminin licensing factors from origins Nuclear Receptor transcription pathway Association of licensing factors with the pre-replicative complexVitamin D receptor SUMOylation of DNA replication proteins Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 The NLRP3 inflammasome Transcriptional regulation of white adipocyte differentiationSUMOylation of chromatin organization proteins Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Association of TriC/CCT with target proteins during biosynthesis Translesion Synthesis by POLH Androgen Receptor Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of IFNG signaling DNA polymerase eta HSP90 and hnRNPA2/B1 SUMOSUMO is is transferred proteolytically from processed E1 to E2 (UBE2I, UBC9) HSF1 activation Senescence-Associated Secretory Phenotype (SASP) PPAR delta/gamma Downregulation of SMAD2/3:SMAD4 transcriptional activity HDMs demethylateSUMOylationFormation histones of of RNA Incision binding Complex proteins in GG-NER Negative SUMOregulation is conjugated of activity ofto TFAP2E1 (UBA2:SAE1) (AP-2) family transcription factors Endosomal Sorting Complex Required For Transport (ESCRT) Regulation of TP53 Activity through Acetylation RegulationImport ofof pyruvatepalmitoyl-CoA dehydrogenase into the mitochondrial (PDH) complex matrixHSP90 chaperone cycle for steroid hormone receptorsInterconversion (SHR) of nucleotide di- and triphosphatesUb-specific processing proteases Membrane binding and targetting of GAG proteins Signaling by Retinoic Acid Thymidylate synthase Regulation of PTEN gene transcription Tumor susceptibility gene 101 protein HSF1-dependent transactivation Deregulated CDK5 triggersActivation multiple of the neurodegenerative AP-1 family of transcription pathways factors in Alzheimer's disease models Sema3A PAK dependent Axon repulsion Ribonucleoside-diphosphate reductase M2 chain Attenuation phase FCERI mediated MAPK activation Lysine-specific demethylaseSmall ubiquitin-related 4A modifier 1 RegulationUptake ofand actin function dynamics of diphtheria for phagocytic toxin cup formation Tyrosyl-DNA phosphodiesterase 1 Budding and maturation of HIV virion Proto-oncogene c-JUN Activation of E2F1 target genes at G1/S Constitutive Signaling by EGFRvIII Dectin-2 family Downregulation of SignalingERBB2 signaling by ERBB2 Pre-NOTCH Transcription and Translation Synthesis and processing of ENV and VPU Scavenging by Class F Receptors Regulation of TP53 Expression Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants TranscriptionalPIP3 activates activation AKT signaling of cell cycle inhibitor p21 Histone-lysine N-methyltransferaseNonhomologous NSD2 End-Joining (NHEJ) Binding and entry of HIV virion TP53 regulatesTP53 transcription Regulates ofTranscription additional cell of Deathcycle genesReceptors whose and exact Ligands role in the p53 pathwayEyes remain absent uncertain homolog 2 Envelope polyproteinAssembly GP160 Of The HIV Virion eNOS activation AUF1 (hnRNP D0) binds and destabilizes mRNA vRNP Assembly Factors involved in megakaryocyteActivation ofdevelopment PUMA and translocation and platelet to mitochondria production Alpha-defensins Transcription of E2F targets under negative control by TP53p107 regulates(RBL1) andtranscription p130 (RBL2) of Regulationseveral in complex additional ofG2/M TP53 with cellCheckpoints Activity deathHDAC1 through genes whoseAssociation specific with roles Co-factors in p53-dependent apoptosis remain uncertain VEGFR2 mediated vascular permeability Mothers againstTP53 decapentaplegicAutodegradation RegulatesActivation Transcription of NOXA of homologthe andE3 ofubiquitin translocation Genes 3 ligaseInvolved to COP1 mitochondria in Cytochrome C Release HDR through Homologous Recombination (HRR) PIWI-interacting RNAHeat (piRNA) shock biogenesis protein HSPVEGFA-VEGFR2 90-alpha Pathway Formation of Senescence-Associated Heterochromatin Foci (SAHF) Heat shock protein beta-1 EPHA-mediated growth cone collapse TP53 RegulatesRecruitment TranscriptionSUMOylation and ATM-mediated of of DNA transcription phosphorylation RepairSUMOylation Genes factors of repair of andDNA signaling damage proteins response at DNA doubleand repair strand proteinsbreaks Regulation of TP53 Activity through Methylation SMAD2/3SMAD2/3 MH2 Phosphorylation DomainSignaling Mutants Motifby inNODAL CancerMutants in Cancer SMAD4 MH2 RUNX3Domain regulates Mutants CDKN1Ain Cancer transcription DNA repair protein RAD52 homolog DownregulationRUNX3 regulates TGFBR1of TGF-beta BCL2L11 KD Mutantsreceptor (BIM) intranscriptionsignaling Cancer MAPK6/MAPK4 signaling Mitogen-activated protein kinase kinaseCREB-binding kinase 5 protein/p53 Metalloprotease DUBs Signaling by Activin Meiotic synapsis TGF-beta receptor signaling activatesAKT phosphorylates SMADs targets in the cytosol ConstitutiveRegulation Signaling of RUNX3 by AKT1 expression E17K inand Cancer activityG2/M DNA damage checkpoint G0 and Early G1 Oxidative Stress Induced SenescenceTrafficking of AMPA receptors Breast cancerHDR type through1 susceptibility Single protein Strand Annealing (SSA) Casein kinase I/MDM2 Ovarian tumor domain proteases Stabilization of p53 Werner syndrome ATP-dependent The role of GTSE1 in G2/M progression after G2 checkpoint Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Oncogene Induced Senescence Homologous DNA Pairing and Strand Exchange Recruitment of mitotic centrosome proteins and complexes Resolution ofBloom D-loop syndrome Structures protein through Holliday Junction Intermediates Loss of proteins required for interphase microtubule organization from the centrosome Serine/threonine-protein kinase Chk2 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Loss of Nlp from mitotic centrosomes CDK-mediated phosphorylationPTK6 Regulates and Cell removal Cycle of Cdc6 PI5P Regulates TP53 Acetylation Anchoring of the basal body to the plasma membrane TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Meiotic recombination tRNA processing in the mitochondrion Recruitment of NuMA to mitotic centrosomes MAPK3 (ERK1) activation CDK2/Cyclin A1 Branched-chain amino acid catabolism AURKA Activation by TPX2 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Regulation of TP53 Degradation rRNA processing in the mitochondrion Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Phosphorylation of proteins involved in the G2/MDNA transition Damage/Telomere by Cyclin A:Cdc2 Stress Inducedcomplexes Senescence Regulation of TP53 Activity through Phosphorylation Endoplasmic reticulum-associatedtRNA modification amyloid in beta-peptide-binding the mitochondrion protein CDK2/CDK4 SCF(Skp2)-mediated degradation of p27/p21 TP53 Regulates Metabolic Genes Regulation of PLK1 Activity at G2/M Transition CDK1/Cyclin A Orc1 removal from chromatin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/earlyTP53 Regulates G1 Transcription of Genes InvolvedG2 Phase in G2 Cell Cycle Arrest Mitotic Metaphase/Anaphase Transition ActivationCyclin E associatedof the pre-replicative events during complex G1/S transition Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cyclin A:Cdk2-associatedp53-Dependent G1 Activation eventsDNA Damage at S of phase ATR Response entryin response to replication stress RHO GTPases Activate Formins Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 SeparationMitotic of Sister Prometaphase Chromatids Negative regulators of DDX58/IFIH1 signaling GAR transformylase Mitotic Telophase/CytokinesisSerine/threonine-protein kinase PLK1 ISG15 antiviral mechanism Activation of NIMANuclear Kinases Pore NEK9, Complex NEK6,Regulation (NPC) NEK7 Disassembly of APC/C activators between G1/S and early anaphase AICAR transformylase MASTLCyclin Facilitates A/B1/B2 Mitotic associated ProgressionChk1/Chk2(Cds1) events during mediated G2/M transition inactivation ofTP53 Cyclin B:Cdk1Regulates complex Transcription of Caspase Activators and Caspases Purine ribonucleoside monophosphate biosynthesis PhosphorylationPhosphorylationAPC/C:Cdc20 of mediated ofEmi1 the APC/C degradation of Cyclin B DepolymerisationCondensation of Prometaphase of the Nuclear ChromosomesLamina Golgi CisternaeResolution Pericentriolar of Sister ChromatidStack Reorganization CohesionMitotic Prophase G2/M DNA replication checkpoint Amino acid synthesisGlutaminase and interconversion kidney isoform, (transamination) mitochondrial Condensation of Prophase E2F-enabled inhibition of pre-replication complex formation Glutamate Neurotransmitter Release Cycle Polo-like kinase mediatedCyclin-dependent events kinase 1/cyclin B

CysteineMacroautophagy protease ATG4B

Breakdown of the nuclear lamina Synthesis, secretion,Neurotransmitter and deacylation clearanceUptake of GhrelinAnthrax and function lethal of factor anthrax toxins Synthesis of PC Caspase-6 Butyrylcholinesterase Microtubule-associated protein tau

Activation of caspasesApoptotic through cleavageapoptosome-mediated of cellular cleavage proteins SMAC-mediatedCaspase-mediated dissociationSMAC binds of IAP:caspasecleavage to IAPs of cytoskeletalcomplexes proteins

Caspase-7