Glycoprotein hormones alpha chain Hormone ligand-binding receptors Glycoprotein hormones Mineralocorticoid biosynthesis TFAP2 (AP-2) family regulates transcriptionAndrogenThyroid of biosynthesis growth stimulating factors hormone and their receptor receptors Reactions specificThyroxine to the complex biosynthesis N-glycan synthesis pathway Multidrug resistance-associated proteinGlucagon-like 5 peptide 1 receptor 78 kDa glucose-regulated protein Hyaluronan biosynthesis and export Glucagon-type ligand receptors Platelet degranulation G alpha (s)ABC-family signalling proteinsevents mediated transport PERKATF6 regulates(ATF6-alpha) gene activates expression chaperones Guanine nucleotide-binding protein G(s), subunit alpha Regulation of HSF1-mediated heat shock response Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ATF6 (ATF6-alpha)IRE1alpha activates activates chaperone chaperones genes Parathyroid hormone receptor Serotonin (5-HT)Prostacyclin receptorG alpha signalling (z) signalling through events prostacyclin receptor Ras-related protein Rab-9A G alpha (q) signalling events GlucagonHedgehog signaling 'off' in metabolic state regulation PKA activation in glucagon signalling RAB geranylgeranylation Ubiquitin carboxyl-terminal hydrolase 1 Vasopressin regulates renal water homeostasis via Aquaporins Rap guanine nucleotide exchange factor 3 Class B/2 (Secretin Neuropeptidefamily receptors) S receptor Rap guanine nucleotide exchange factor 4 RetrogradeRAB transportGEFs exchange at the Trans-Golgi-Network GTP for GDP on RABs Serotonin receptorsRegulator of G-protein signaling 4 Fanconi Anemia Pathway Recognition of DNA damage by PCNA-containing replication complex Regulation of insulin secretion Rap1 signalling G alpha (i) signalling events Integrin alphaIIb beta3 signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC Galanin receptor 3 Rac GTPase-activating protein 1 Peptide ligand-binding receptors MHC class II antigen presentation Kinesins Alpha-synuclein Rho GTPase cycle Amyloid fiber formation COPI-dependent Golgi-to-ER retrograde traffic Prostaglandin E synthase Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Post-translationalIron uptake modification: and transport synthesis of GPI-anchored proteins Transport of organic anions Inactivation, recoveryParadoxical and regulation activation of the of RAFphototransduction signaling by kinase cascade inactive BRAF Signaling by RAS mutants Solute carrier organic anion transporter family member15-hydroxyprostaglandin 1B3Proton-coupled dehydrogenaseFolate folate receptor transporter [NAD+] beta Solute carrier organic anion transporter family member 1B1 Clathrin-mediatedBeta-arrestin-1 endocytosis Golgi Associated Vesicle Biogenesis Thrombin signallingAminopeptidase through proteinase activated receptors (PARs) Activation of SMO SynthesisArachidonate of 15-eicosatetraenoic 15-lipoxygenase, acid type derivatives II Cargo recognitionLysosome for clathrin-mediated Vesicle Biogenesis endocytosis Recycling of bile acids and salts Signaling by BRAF and RAFMAP2K fusions and MAPK activation Fatty acid synthase Serine hydroxymethyltransferase, cytosolic ActivatedSignaling NOTCH1 by Transmits high-kinase Signal activity to the BRAF Nucleus mutants ChREBP activates metabolic gene expression Folate transporter 1 Signaling by moderate kinase activity BRAF mutants Vitamin B5 (pantothenate) metabolism Carnitine synthesis Chemokine receptors bind chemokines UDP-glucuronosyltransferaseGlucuronidation 1-10 ActivationFatty of geneacyl-CoA expression biosynthesis by SREBF (SREBP) Metabolism of folatePrelamin-A/C and pterines EGFR Transactivation by Gastrin Interleukin-10ATF4 signaling activates genes Synthesis of Lipoxins (LX) E3 ubiquitin-protein ligase UHRF1 Assembly of collagen fibrilsCollagen and degradationother multimeric structuresInterleukin-8 DNA methylation XBP1(S)Fructose catabolismactivates chaperone genes Ethanol oxidation Activation of Matrix Metalloproteinases RA biosynthesis pathway MatrixDegradation metalloproteinase of the extracellular (2 and 3) matrix Flap endonucleaseEarly Phase of1 HIV Life Cycle Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterolAldehyde dehydrogenase HDR through MMEJ (alt-NHEJ) Removal of the Flap Intermediate fromCOPII the C-strand(CoatFolate Protein receptor 2) Mediated alpha VesicleBile Transport acid receptor FXR Removal of the Flap Intermediate Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarateEPH-ephrin mediated repulsion of cells Synthesis of bile acids and bile salts Collagenase FCERI mediated NF-kB activation PCNA-Dependent Long Patch Base Excision Repair COPI-mediated anterograde transport NADPH regeneration CLEC7A/inflammasome pathway POLB-Dependent Long Patch Base Excision Repair Cargo concentrationSynthesis in ofthe bile ER acids and bile salts via 27-hydroxycholesterol TAK1 activatesRegulatedTRAF6 NFkB mediated proteolysis by phosphorylation NF-kB of p75NTR activation and activation of IKKs complex Isocitrate dehydrogenase [NADP] cytoplasmic RIP-mediated NFkB activation via ZBP1 DEx/H-boxMAP3K8Downstream helicases (TPL2)-dependent activate TCR signalingtype MAPK1/3 I IFN and activation inflammatory cytokines production Synthesis of LeukotrienesAntigen processing: (LT) and Eoxins Ubiquitination (EX) & Proteasome degradationIKBKG deficiency causes anhidroticCLEC7A ectodermal (Dectin-1) dysplasia signaling with immunodeficiency (EDA-ID) (via TLR) Phase I - Functionalization of compounds NF-kB isCD209 activated (DC-SIGN) Activationand signals signaling of survivalNF-kappaB in B cells DNA-(apurinic or apyrimidinic site) lyase 5-lipoxygenase/FLAP Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Endogenous sterols Synthesis of 5-eicosatetraenoic acids IkBA variant leadsInterleukin-1 to EDA-ID family signaling Resolution of AP sites via the multiple-nucleotide patch replacement pathway Nuclear factor NF-kappa-B complex Interleukin-1 processing Telomere Extension By Telomerase ResolutionDisplacement of Abasic of DNA Sites glycosylase (AP sites) by APEX1 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway Alpha-galactosidase A Telomerase reverse transcriptase Sphingomyelin phosphodiesterase Xenobiotics Neutrophil degranulationDownstream signal transduction Post-translationalRHO GTPases activate protein IQGAPs phosphorylation Aryl hydrocarbon receptor STAT6-mediated induction of chemokines Signal transducer and activator ofGlycosphingolipid transcription metabolism 6 PPARA activates gene expression Menin Niemann-Pick C1 protein Formation of the beta-catenin:TCF transactivating complex LDL clearance RUNX1 regulates transcription of genes involved in differentiation of HSCs Interleukin-4 and 13 signaling PTK6 Expression PTK6 promotes HIF1A stabilization Histone-lysine N-methyltransferase MLL Sodium/nucleoside cotransporter 2 Oxygen-dependent asparagine hydroxylation of Hypoxia-inducibleDeactivation Factorof the beta-catenin Alpha transactivating complex Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Translesion synthesis by POLI Acyl chain remodelling of PI Neddylation Acyl chain remodelling of PE Regulation of geneKeap1/Nrf2 expression by Hypoxia-inducible Factor PhospholipaseAcyl chain A2 remodelling group 1B of PC Hypoxia inducible factors; HIF-1-alpha,Beta-glucocerebrosidase HIF-2-alphaRUNX1 regulates genes involved in megakaryocyte differentiation and platelet function DNA polymerase iota Synthesis of PA Acyl chain remodelling of PS Acyl chain remodelling of PG Aryl hydrocarbon receptor signallingNuclear receptor ROR-gammaCREB phosphorylationRecycling pathway through of theL1 activation of Ras NOTCH1 Intracellular Domain Regulates Transcription Dihydrofolate CREBreductase phosphorylation Regulation of lipid metabolismCircadianp75NTR byHDACsClock Peroxisome negatively deacetylate proliferator-activatedregulates histones cell cycle via receptor SC1 alpha (PPARalpha) ERK/MAPK targets BMAL1:CLOCK,NPAS2Constitutive activatesRORA circadianactivatesSignaling genebygene NOTCH1 expression expression HD+PEST DomainPKMTs methylateMutants histone lysines Gastrin-CREB signalling pathway via PKC and MAPK TranscriptionalConstitutive SignalingRUNX3activation regulates by of NOTCH1mitochondrial p14-ARF PEST biogenesis Domain Mutants RibosomalRSK activation protein S6 kinase alpha 3 NoRCNR1D1 negatively (REV-ERBA) regulatesRepression represses rRNATranscription of geneWNT expression expression target of E2F genestargets under negative control by DREAM complex DNA topoisomerase II Cilium Assembly Gap-fillingTranslesion DNA repair synthesis synthesis by and POLK ligation in TC-NER Gap-filling DNA repair synthesisTermination and ligation of translesion in GG-NER DNA synthesis ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Dual Incision in GG-NER Dual incision in TC-NER Thyroid hormone receptor SMAD2/SMAD3:SMAD4Histone deacetylase heterotrimer regulates transcription CDT1 association with the CDC6:ORC:origin complex RNA Polymerase I Transcription Initiation DNA polymerase kappa VLDLR internalisationLXR-beta and degradation Removal ofGeminin licensing factors from origins Nuclear Receptor transcription pathway Association of licensing factors with the pre-replicative complexVitamin D receptor SUMOylation of DNA replication proteins Activated PKN1 stimulates transcription of