Rutgers Brain Health Institute 2019 - 2020 Plenary Seminar Series

Total Page：16

File Type：pdf, Size：1020Kb

Rutgers Brain Health Institute 2019 - 2020 Plenary Seminar Series Patricia Janak Bloomberg Distinguished Professor Department of Psychological and Brain Sciences; Department of Neuroscience, Jan 23, 2020 Johns Hopkins School of Medicine. The Janak Lab studies behavioral and neural mechanisms of associative learning and behavioral and neural mechanisms for the acquisition of reward-based associations as it relates to drug and alcohol addiction and overeating. Garret Stuber Professor, Center for Neurobiology of Addiction, Pain, and Emotion; Department of Anesthesiology and Pain Medicine; Department of Pharmacology Mar 12, 2020 University of Washington. The major goal of Stuber Lab research is to delineate the neural circuits involved in the manifestation of neuropsychiatric disorders including addiction, maladaptive eating behaviors, and anxiety. Rutgers Brain Health Institute 2019 - 2020 Plenary Seminar Series Carol Mason Professor of Pathology & Cell Biology, Neuroscience and Ophthalmic Sciences, Columbia University. Mar 26, 2020 The Mason Lab studies axon guidance in the visual pathways, analyzing the behaviors, cellular interactions and molecular directives of retinal axon growth cones during avoidance and crossing of the midline at the optic chiasm. Randy Bruno Associate Professor of Neuroscience, Mortimer B. Zuckerman Mind Brain April 2, 2020 Behavior Institute, Columbia University. The Bruno Lab studies neural pathways and circuit elements that contribute to sensory perception, learning, remembering and reasoning. Larry Young William P. Timmie Professor of Psychiatry and Behavioral Sciences, Director Center for Translational Social Neuroscience, & April 16, 2020 Chief, Behavioral Neuroscience and Psychiatric Disorders. Emory University, GA Dr. Young studies how genetic, cellular and neurobiological mechanisms regulate complex social behavior, including social cognition and social bonding. Rutgers Brain Health Institute 2019 - 2020 Plenary Seminar Series Susan Amara Scientific Director of the Intramural Research Program at NIMH, Chief, Laboratory of Molecular and Cellular Neurobiology, NIH. May 7, 2020 Dr. Amara’s Lab studies the structure, function, and cellular physiology of neurotransmitter transporters, including glutamate transporters as well as the biogenic amine transporters, major targets for psychostimulant drugs and antidepressants. Mirganka Sur Newton Professor of Neuroscience and Director of the Simons Center for the Social May 21, 2020 Brain, MIT. Dr. Sur studies the organization, plasticity and dynamics of the cerebral cortex of the brain using experimental and theoretical approaches. Visit http://brainhealthinstitute.rutgers.edu/ for more information .

Copy Link

Recommended publications

Setting the Occasion for Incentive Motivation: Implications for Addiction
bioRxiv preprint doi: https://doi.org/10.1101/428409; this version posted September 26, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Fraser & Janak, 09.26.2018 – preprint copy - BioRxiv Setting the Occasion for Incentive Motivation: Implications for Addiction Kurt M. Frasera & Patricia H. Janaka,b,c a Department of Psychological & Brain Sciences, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD 21218 b The Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205 c Kavli Neuroscience Discovery Institute, Johns Hopkins School of Medicine, Baltimore, MD 21205 Correspondence: To either Kurt M. Fraser ([email protected]) or Patricia H. Janak ([email protected]) as above Abstract The context in which reward-paired cues are encountered sets the occasion for appropriate reward-seeking but may also spur inappropriate behaviors such as the renewal of drug-seeking. The psychological processes underlying occasion setting remain unclear as contexts are diffuse and difficult to isolate from other stimuli. To overcome this, we modeled a context as a phasic and discrete event – an occasion setter – which allowed for control over its presentation and influence on cue-driven reward-seeking. This allowed us to directly assess how occasion setters, like contexts, regulate the predictive and motivational significance of Pavlovian cues. Male rats (n=50) were trained in a Pavlovian paradigm where the presentation of an ambiguous conditioned stimulus was reinforced only if preceded by an occasion setting cue.
[Show full text]
Mu-Opioid Receptor Activation in the Medial Shell of Nucleus Accumbens Promotes Alcohol Consumption, Self-Administration and Cue-Induced Reinstatement
UCSF UC San Francisco Previously Published Works Title Ventral Pallidum Neurons Encode Incentive Value and Promote Cue-Elicited Instrumental Actions. Permalink https://escholarship.org/uc/item/6v2169m1 Journal Neuron, 90(6) ISSN 0896-6273 Authors Richard, Jocelyn M Ambroggi, Frederic Janak, Patricia H et al. Publication Date 2016-06-01 DOI 10.1016/j.neuron.2016.04.037 Peer reviewed eScholarship.org Powered by the California Digital Library University of California Neuropharmacology 108 (2016) 14e23 Contents lists available at ScienceDirect Neuropharmacology journal homepage: www.elsevier.com/locate/neuropharm Mu-opioid receptor activation in the medial shell of nucleus accumbens promotes alcohol consumption, self-administration and cue-induced reinstatement * Jocelyn M. Richard , Howard L. Fields Department of Neurology, The Wheeler Center for the Neurobiology of Addiction, Alcoholism and Addiction Research Group, University of California, San Francisco, CA, USA article info abstract Article history: Endogenous opioid signaling in ventral cortico-striatal-pallidal circuitry is implicated in elevated alcohol Received 15 November 2015 consumption and relapse to alcohol seeking. Mu-opioid receptor activation in the medial shell of the Received in revised form nucleus accumbens (NAc), a region implicated in multiple aspects of reward processing, elevates alcohol 6 April 2016 consumption while NAc opioid antagonists reduce it. However, the precise nature of the increases in Accepted 8 April 2016 alcohol consumption, and the effects of mu-opioid agonists on alcohol seeking and relapse are not clear. Available online 14 April 2016 Here, we tested the effects of the mu-opioid agonist [D-Ala2, N-MePhe4, Gly-ol]-enkephalin (DAMGO) in rat NAc shell on lick microstructure in a free-drinking test, alcohol seeking during operant self- Keywords: Alcohol administration, extinction learning and expression, and cue-reinforced reinstatement of alcohol Nucleus accumbens seeking.
[Show full text]
Kurt Michael Fraser, Phd 142 Weill Hall Cell: #3200, Berkeley, CA 94720 Email: [email protected]
Updated May 2021 Kurt Michael Fraser, PhD 142 Weill Hall Cell: #3200, Berkeley, CA 94720 Email: [email protected] CURRENT POSITION Postdoctoral Scholar May 2021-Present University of California - Berkeley Supervisor: Stephan Lammel, PhD EDUCATION Johns Hopkins University, Baltimore, MD 2021 PhD in Psychological & Brain Sciences (Biopsychology) Supervisor: Patricia H. Janak, PhD Dissertation Topic: Setting the Occasion for Reward-seeking in Brain and Behavior Johns Hopkins University, Baltimore, MD 2017 MA in Psychological & Brain Sciences (Biopsychology) Supervisor: Patricia H. Janak, PhD Master’s Thesis: Dorsal and Ventral Striatal Systems in the Attribution of Incentive Salience to Reward-Paired Cues University of Michigan, Ann Arbor, MI 2015 BS in Neuroscience with High Honors & Distinction Supervisor: Shelly B. Flagel, PhD Thesis: Contributions of Dopamine D2 and D3 Receptors to Pavlovian Conditioned Approach RESEARCH INTERESTS Neurobiological mechanisms of cue-triggered motivated behavior: • How are reward learning and conditioned motivation separable in both behavior and neurobiology? • What neural circuits underlie the attribution of conditioned motivation to reward-paired cues? • How is ambiguity about the motivational value of conditioned cues in the environment resolved to produce reward-seeking? • What is the content of learning? • How do neural circuits supporting adaptive reward-seeking go awry in mental health disorders such as alcohol abuse and addiction? RESEARCH SUPPORT AND FELLOWSHIPS NIH BRAIN Initiative Fellows NRSA Postdoctoral Fellowship (F32 MH127792) 2021-2024 Using large-scale electrophysiology to study the role of midbrain dopamine neurons underlying motivated behavior NIH NRSA Predoctoral Fellowship (F31 DA046136) 2019-2021 The role of the basolateral amygdala in occasion setting Kurt M. Fraser Curriculum Vitae Updated May 2021 MANUSCRIPTS IN PREPARATION Fraser KM, Collins V, Pat F, Saunders BT, & Janak PH.
[Show full text]
PBS Graduate Student Handbook
JOHNS HOPKINS UNIVERSITY Department of Psychological & Brain Sciences Graduate Student Handbook JHU Psychological & Brain Sciences Graduate Handbook | Updated April 2021 TABLE OF CONTENTS Introduction Department Directory REQUIREMENTS FOR THE PH.D. Duration of Program Faculty Advisor & PhD Student commitments Courses & Seminars GRADUATE CURRICULUM Fundamentals in Biopsychology and Fundamentals in Cognitive Psychology Core Topics A and Core Topics B Advanced Seminars Statistics Topics in PBS Topical Seminars Professional Development Seminar Lab Meetings Responsible Conduct in Research Colloquium and Research Registration Summer Registration Grades GRADUATE STUDENT TIMETABLE PROGRAM MILESTONES ANNUAL COMMITTEE MEETINGS First Year Research Project Advanced Examination Dissertation Proposal Literature Review Dissertation JHU Psychological & Brain Sciences Graduate Handbook | Updated April 2021 Graduate Board Oral Examination/Dissertation Defense REQUIREMENTS FOR THE M.A. University Requirements Department Requirements TEACHING ASSISTANTSHIPS The Teaching Practicum Policy on Graduate Teaching Assistantships Student Preferences TA Duties Faculty Responsibilities Grievance Procedure Procedures for Posting Grades Additional Teaching Opportunities Additional Teaching Resources EVALUATING STUDENT PROGRESS Academic Review Policy Graduate Student Probation, Funding Withdrawal, and Dismissal Policy DEPARTMENT EVENTS AND SERVICE Colloquia Student Representation on Steering Committee Student Service to the Department INSTITUTIONAL POLICIES GRADUATE
[Show full text]
2020 Participating Bloomberg Distinguished Professors
2020 Participating Bloomberg Distinguished Professors Participating faculty are listed alphabetically by last name: Rexford Ahima: Endocrinology, Diabetes, & Metabolism, SOM; Epidemiology, BSPH; Community-Public Health, SON Project: Impact of Lmo4 knockout in brain on time-restricted feeding and energy metabolism. Knockout of Lmo4 in brain correlates with gain in body weight. We are studying the effects of restricting access to food during certain time of the day to determine the kinetics of weight gain and energy metabolism. Undergraduates will work on mouse breeding, coordinating food access to animals, measuring body composition, gene expression analysis and isolation of tissues. Preferred (or required) skills and/ or experience: Basic knowledge in biology, chemistry, math and physics. Positions available: 1 Work location: Bayview Medical Center, Asthma and Allergy Center, 5501 Hopkins Bayview Cir, Rm 2A62 Chuck Bennett: Physics and Astronomy, KSAS; JHU Applied Physics Lab (APL) Project: The research project relates to the Cosmological Large Angular Scale Surveyor (CLASS) telescope array that Johns Hopkins University operates high in the Andes Mountains of northern Chile. The research group builds new instrumentation, improves existing instrumentation, operates the telescope system to survey the sky, and analyzes data from the survey. The overall two major goals of the research are: (1) to determine, via measurement, the detailed process that led to the first stars forming; and (2) to determine, via measurement, the nature of the first fraction of a second of the creation of the universe. To achieve these goals, CLASS conducts a survey of the polarized cosmic microwave background radiation (the remnant glow from billions of years ago) over most of the sky.
[Show full text]
Phasic Activation of Ventral Tegmental, but Not Substantia Nigra, Dopamine Neurons Promotes Model-Based Pavlovian Reward Learning
bioRxiv preprint doi: https://doi.org/10.1101/232678; this version posted December 13, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Phasic Activation of Ventral Tegmental, but not Substantia Nigra, Dopamine Neurons Promotes Model-Based Pavlovian Reward Learning R. Keiflin1*, H. J. Pribut1, N. B. Shah1, P. H. Janak1,2,3* 1 Department of Psychological and Brain Sciences, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore MD 21218 USA 2 The Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore MD 21205 USA 3 Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA *Correspondence: Patricia H. Janak, Ph.D. Johns Hopkins University 3400 N. Charles Street Dunning Hall, room 246 Baltimore, MD 21218 [email protected] ph: 415-509-1190 Ronald Keiflin, Ph.D. Johns Hopkins University 3400 N. Charles Street Dunning Hall, room 246 Baltimore, MD 21218 [email protected] ph: 510-501-4875 bioRxiv preprint doi: https://doi.org/10.1101/232678; this version posted December 13, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. ABSTRACT: Dopamine (DA) neurons in the ventral tegmental area (VTA) and substantia nigra (SNc) encode reward prediction errors (RPEs) and are proposed to mediate error-driven learning. However the learning strategy engaged by DA-RPEs remains controversial. Model-free associations imbue cue/actions with pure value, independently of representations of their associated outcome.
[Show full text]
Psychology & Neuroscience Undergraduate
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | UNC THIS ISSUE Psychology & Neuroscience Meet a Gil Intern: Page 2 Undergraduate Newsletter Graduation: Page 2 Volume 6 | Issue 8 April 2018 Jobs & Opps: Page 3 Student SpotlightStudent Spotlight Meet Christina Cornea, a Biology and (soon to be!) Neuroscience double major IMPT DATES who is conducting research in the laboratory of Dr. John Gilmore. Tell us about your research. I am studying the asymmetry between the left and Honors Deadline right arcuate fasciculus, the white matter tract that con- April 20 nects cortical regions involved with language. My research looks at how the morphology and maturation of the arcu- Classes End ate fasciculus is related to the language ability at age 1 April 27 year. Early childhood is a period of rapid development of white matter tracts and development of cognitive abilities. Reading Days The arcuate is assessed using diffusion weighted MRIs and May 2 and May 5 computer-assisted tractography to delineate the arcuate. What do you like most about your research? Getting to Finals apply my knowledge of neuroscience to unanswered ques- 4/30, 5/1, 3-4, 7-8 tions and knowing that I am making an impact on the world of science. While much is known about the extent to Commencement which asymmetry of the arcuate fasciculus is related to language ability in Sunday, May 13 adults, very little is known about how the asymmetry develops in early child- 3:30 PM hood and how it is related to language. Getting to be part of a team that will Carmichael Arena help future doctors and pediatricians better understand the relationship be- tween brain and language development is incredible.
[Show full text]
CUNY Sts Award-Winners Interior
AWARDS_StS student awards program 7/18/13 3:43 PM Page 3 he 2013 National Science Foundation Grad- Tuate Research Fellowships are among the nation’s most prestigious awards for graduate study in science, technology, engineering and math. This year, The City University of New York proudly celebrates our 23 graduating seniors and recent alumni who won 2013 National Science Foundation Graduate Research Fellowships — more than any other public university system in the Northeast. We’re pleased to spotlight the University’s “All-Star Science Teams” of NSF winners, along with a selection of other honorees from the Class of 2013. The external awards they’ve won underscore the caliber of CUNY’s graduates. These range from feder- ally funded Fulbright Fellowships for research and teaching abroad to acceptance at top-notch graduate and professional institutions around the country, where CUNY alumni are pursuing law, medicine and the full range of arts, sciences and social sciences. New alumni are also entering the workforce, engaging in public service or contributing to charitable activities to enhance their personal growth. This special edition of Salute to Scholars magazine salutes some of these remark- able students. See www.cuny.edu/allstars for a larger listing. The University congratulates all members of the Class of 2013 for enriching our nation and, indeed, our world. Warm best wishes, William P. Kelly, Interim Chancellor CUNY 2013 AWARD RECIPIENTS 1 AWARDS_StS student awards program 7/15/13 3:40 PM Page 4 Mizanur Ahmed Macaulay Honors College at Brooklyn College, ’13 Jonas E. Salk Scholarship Kyle Athayde Macaulay Honors College at Hunter College, ’13 Coro Fellowship Hunter Gross Macaulay Honors College at Hunter College, ’15 Critical Language Scholarship (China) Anna Groysman Macaulay Honors College at Brooklyn College, ’13 Jonas E.
[Show full text]
Kurt Michael Fraser, MA 224 Dunning Hall, 3400 N Charles St Cell: Baltimore, MD 21218 Email: [email protected]
Updated September 2020 Kurt Michael Fraser, MA 224 Dunning Hall, 3400 N Charles St Cell: Baltimore, MD 21218 Email: [email protected] CURRENT POSITION Johns Hopkins University, Baltimore, MD Expected March 2021 PhD Candidate in Psychological & Brain Sciences (Biopsychology) Supervisor: Patricia H. Janak, PhD Dissertation Topic: Setting the Occasion for Reward-seeking in Brain and Behavior EDUCATION Johns Hopkins University, Baltimore, MD 2017 MA in Psychological & Brain Sciences (Biopsychology) Supervisor: Patricia H. Janak, PhD Master’s Thesis: Dorsal and Ventral Striatal Systems in the Attribution of Incentive Salience to Reward-Paired Cues University of Michigan, Ann Arbor, MI 2015 BS in Neuroscience with High Honors & Distinction Supervisor: Shelly B. Flagel, PhD Thesis: Contributions of Dopamine D2 and D3 Receptors to Pavlovian Conditioned Approach RESEARCH INTERESTS Neurobiological mechanisms of cue-triggered motivated behavior: • How are reward learning and conditioned motivation separable in both behavior and neurobiology? • What neural circuits underlie the attribution of conditioned motivation to reward-paired cues? • How is ambiguity about the motivational value of conditioned cues in the environment resolved to produce reward-seeking? • What is the content of learning? • How do neural circuits supporting adaptive reward-seeking go awry in mental health disorders such as alcohol abuse and addiction? RESEARCH SUPPORT AND FELLOWSHIPS NIH National Research Service Award Predoctoral Fellowship (F31 DA046136) 2019-present The role of the basolateral amygdala in occasion setting MANUSCRIPTS IN PREPARATION Fraser KM, Collins V, Pat F, Saunders BT, & Janak PH. Hierarchical control of mesolimbic dopamine and striatal encoding of reward-paired cues governs flexible behavioral responding. Fraser KM, Kim TH, Padovan-Hernandez Y, Chen B, Pat F, Ottenheimer DJ, & Janak PH.
[Show full text]
HHS Public Access Author Manuscript
HHS Public Access Author manuscript Author Manuscript Author ManuscriptAlcohol. Author Manuscript Author manuscript; Author Manuscript available in PMC 2016 December 01. Published in final edited form as: Alcohol. 2015 December ; 49(8): 817–824. doi:10.1016/j.alcohol.2015.03.003. Corticostriatal circuitry and habitual ethanol seeking Jacqueline M. Barkera, Laura H. Corbitb, Donita L. Robinsonc, Christina M. Gremeld, Rueben A. Gonzalese, and L. Judson Chandlera aDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA bSchool of Psychology, University of Sydney, Sydney, Australia cBowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA dDepartment of Psychology, Neuroscience Graduate Program, University of California San Diego, La Jolla, CA, USA eDepartment of Pharmacology, The University of Texas at Austin, Austin, TX, USA Abstract The development of alcohol-use disorders is thought to involve a transition from casual alcohol use to uncontrolled alcohol-seeking behavior. This review will highlight evidence suggesting that the shift toward inflexible alcohol seeking that occurs across the development of addiction consists, in part, of a progression from goal-directed to habitual behaviors. This shift in “response strategy” is thought to be largely regulated by corticostriatal network activity. Indeed, specific neuroanatomical substrates within the prefrontal cortex and the striatum have been identified as playing opposing roles in the expression of actions and habits. A majority of the research on the neurobiology of habitual behavior has focused on non-drug reward seeking. Here, we will highlight recent research identifying corticostriatal structures that regulate the expression of habitual alcohol seeking and a comparison will be made when possible to findings for non-drug rewards.
[Show full text]
Benjamin T. Saunders, Phd Dunning Hall 3400 N Charles St • Baltimore MD 21218 • [email protected]
May 2015 Benjamin T. Saunders, PhD Dunning Hall 3400 N Charles St • Baltimore MD 21218 • [email protected] Current Position Postdoctoral Fellow, 2015 - Johns Hopkins University Supervisor: Patricia H. Janak, PhD Education and Training Postdoctoral Scholar, 2013-2014 University of California, San Francisco (UCSF) Supervisor: Patricia H. Janak, PhD University of Michigan, Ann Arbor, MI PhD in psychology/biopsychology: 2012 MS in psychology/biopsychology: 2009 Supervisor: Terry E. Robinson, PhD West Virginia University, Morgantown, WV BS in biology, BS in psychology, minors in philosophy and communications: 2007 Summa cum laude, University Honors Scholar Grants and Fellowships NIDA National Research Service Award Postdoctoral Fellowship (F32 DA036996): 2014-2017 Title: Ventral tegmental area dopamine in cocaine self administration and relapse NIDA National Research Service Award Predoctoral Fellowship (F31 DA030801): 2011-2013 Title: Variation in the ability of drug cues to reinstate drug seeking Rackham Graduate School Research Grant, University of Michigan: 2011-2012 Title: Nucleus accumbens dopaminergic regulation of cue-induced relapse NIDA Predoctoral Training Grant (T31 DA007281): 2007-2008 Howard Hughes Medical Institute Undergraduate Research Fellowship: 2005 Research Experience USCF, postdoctoral scholar: Jan 2013-Dec 2014 Research Interests: • Dissecting neural circuits causally involved in drug taking and relapse Techniques: • In vivo optogenetics and electrophysiology in transgenic rat lines University of Michigan, Graduate
[Show full text]
Inside Psychology
Inside Summer 2019 Volume 15 Psychology Psychological & Brain Sciences University of California, Santa Barbara INSIDE THIS ISSUE A Story of Growth The Department of Psychological & Brain Sciences (PBS) • New Faculty Profiles (p.7, 14, 27, 30, 32) is home to 42 world-renowned faculty, 63 Ph.D. students, and 2500 undergraduate majors. Together we are Alumni Council Launched • pursuing cutting-edge science that expands our (p.3) understanding of the mind, brain, and behavior. • Student Awards (p.23) The past year has been marked by tremendous growth • Alumni Spotlight (p.25) for the Department, with 5 new faculty hires and • Class Notes (p.40) University approval for a state-of-the-art building dedicated to undergraduate education. The new instructional classroom building will be positioned between Psychology and BioEngineering, serving “We are committed to ensuring that the pursuit of students from PBS and beyond. higher education is available to all of the best The number of students choosing to major in PBS is also and brightest students in growing rapidly. This year we are enjoying an all-time California and beyond.” high of 2510 undergraduate students across our PBS and Biopsychology Bachelor of Science degrees. We extend a warm welcome to these scholars, who will soon join the ranks of our Gaucho Alumni family. Inside Page 2 Psychology Thank you to the Alumni, Faculty, Staff, Parents, and Friends who gave back to the Department this year. Your generosity will serve future generations of Gauchos. Visit our new website and stay in touch at psych.ucsb.edu Inside Page 3 Psychology PBS Alumni Council Launched The mission of the Council is to deepen ties between alumni, faculty, and students To further engage our students and connect with our alumni, the Department of Psychological & Brain Sciences is turning to the experts.
[Show full text]