31 May, 2021 Franklin Templeton Investment Funds Franklin Biotechnology Discovery Fund A (acc) USD This fund is managed by Franklin Templeton International Services S.à r.l. EFC Classification Equity Biotechnology Price +/- Date 52wk range 40.80 EUR 0.13 28/05/2021 36.82 50.31

Issuer Profile Administrator Franklin Templeton International Services S.à r.l. The Fund aims to achieve capital appreciation by investing principally in equity securities Address 8A, rue Albert Borschette 1246 of biotechnology companies and discovery research firms mainly located in the US. City Luxembourg Tel/Fax +352 46 66 67 212 Chart 5 year Website www.franklintempleton.lu

General Information ISIN LU0109394709 Fund Type Capitalization 50 Quote Frequency daily Quote Currency USD 45 Currency USD Foundation Date 03/04/2000 40 Fund Manager Wendy Lam Legal Type Investment company according to Luxembourg law 35 UCITS Yes Financial Year End 30/06/2020 30 Fund size 1,786,183,025.88 USD Minimal Order 5,000.00 USD 25

Costs 20 Entry fee 5.75 % 2017 2018 2019 2020 2021 Infront Finance Exit fee 0.00 % 38 Days 200 Days Operation costs 1.50 % Ongoing charges 1.83 %

Fund Returns 2016 2017 2018 2019 2020 2021 Returns -15.18 2.77 -12.34 36.10 16.74 -8.55 Category Average Category Ranking / / / / / / 40

20 s e u l a V 0

-20 2016 2017 2018 2019 2020 2021

Returns Category Average

Fund Ratios (end previous month) Timing YTD 1 month 6 months 1 year 3 year 5 year Performance Franklin Templeton Investment Funds Franklin Biotechnology Discovery Fund A (acc) USD -4.26 % 0.75 % 10.52 % 23.66 % 12.07 % 10.78 % Volatility Franklin Templeton Investment Funds Franklin Biotechnology Discovery Fund A (acc) USD 15.27 % 22.74 % 21.59 % 31 May, 2021 Franklin Templeton Investment Funds Franklin Biotechnology Discovery Fund A (acc) USD This fund is managed by Franklin Templeton International Services S.à r.l. EFC Classification Equity Biotechnology Price +/- Date 52wk range 40.80 EUR 0.13 28/05/2021 36.82 50.31

Participations (31/12/2020)

Horizon Pharma Plc Participation Percentage INC SEAGEN INC GILEAD SCIENCES INC 5.78 % Horizon Pharma Plc GILEAD SCIENCES INC INC 5.70 % PTC THERAPEUTICSSE AINGCEN INC Regeneron Pharmaceuticals Inc 4.91 % VERTEX PHARMACEUTICALS INC inc 4.81 % PTC THERAPEUTICS INC IOVANCE BIOTHERAPEUTICS INC 4.24 % GW Pharmaceuticals PLC VERTEX PHARMACEUTICALS INC ILLUMINA INC 4.01 % GW Pharmaceuticals PLC GW Pharmaceuticals PLC 3.49 % PTC THERAPEUTICS INC 3.07 % ILLUMINA INC Regeneron Pharmaceuticals Inc SEAGEN INC 2.70 % ILLUMINA INC Regeneron Pharmaceuticals Inc Horizon Pharma Plc 2.66 % IOVANCE BIOTHERAPEUTICS INC Amgen inc

IOVANCE BIOTHERAPEUTICS INC Amgen inc

Geographical composition (31/12/2020)

Netherlands Switzerland Netherlands Denmark Switzerland Canada Denmark Country Percentage United Kingdom Canada United States of America 87.96 % United Kingdom United Kingdom 3.63 % Canada 2.64 % Denmark 2.44 % Switzerland 1.31 % Netherlands 0.99 %

United States of America

United States of America

Sector composition (31/12/2020)

Other Diversified Financial Services Diversified Capital Markets Other Diversified Financial Services Life Sciences Tools & Services Diversified Capital Markets Pharmaceuticals Life Sciences Tools & Services Pharmaceuticals

Sector Percentage Biotechnology 80.81 % Pharmaceuticals 12.92 % Life Sciences Tools & Services 4.01 % Diversified Capital Markets 0.96 % Biotechnology Other Diversified Financial Services 0.27 % Biotechnology