Schedule of Investments(A) March 31, 2021 (Unaudited)
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Prostate Cancer in Focus
PROSTATE CANCER IN FOCUS Current Developments in the Management of Prostate Cancer Section Editor: Andrew J. Armstrong, MD Prostate Cancer Prostate PSMA-Targeted Therapy in Prostate Cancer Scott T. Tagawa, MD, MS Professor of Medicine and Urology Weill Cornell Medicine New York, New York H&O What is prostate-specific membrane agent such as a monoclonal antibody might be able to antigen (PSMA), and what makes it a good target target a tumor without binding to other PSMA-positive for the treatment of prostate cancer? sites owing to its large size and physical inability to reach luminal sites of expression that are separated from the ST PSMA is a cell surface antigen that is expressed to vasculature by tight junctions. a limited degree on certain normal cells in the body but generally is highly overexpressed in the setting of prostate H&O How is PSMA positivity established? cancer. Normal cells that express PSMA are located in the prostate, salivary, and lacrimal glands; the proximal part ST Imaging and biopsy are the main ways to establish of the small intestine; the proximal renal tubules; and PSMA positivity. Multiple imaging modalities are avail- some ganglia. In the setting of prostate cancer, PSMA able worldwide. The agent indium In 111 capromab expression generally increases along with the cancer grade, pendetide (ProstaScint) has been approved for years in and it also increases following hormonal therapy. In addi- the United States, and the US Food and Drug Adminis- tion, PSMA expression tends to be higher in metastatic tration (FDA) approved the use of gallium Ga 68 PSMA- sites than in primary tumors. -
City of Vadnais Heights Accounts Payable Printed: 08/28/2018 15:50 User:Leslee Checks by Date - Detail by Check Date Detail
City of Vadnais Heights Accounts Payable Printed: 08/28/2018 15:50 User:leslee Checks by Date - Detail By Check Date Detail Check Amount Check No: 76626 Check Date: 08/21/2018 Vendor: ZuehlkeJ Jason J Zuehlke Bean bag tournament vendor HD 08/21/2018 200.00 Check Total: 200.00 Date Totals: 200.00 Check No: 76627 Check Date: 09/04/2018 Vendor: AspenMil Aspen Mills 221384 Uniforms - P Yang 08/23/2018 517.95 Check Total: 517.95 Check No: 76628 Check Date: 09/04/2018 Vendor: AutoData ADP, INC 520015802 PP ending 8/17/18 08/28/2018 320.17 Check Total: 320.17 Check No: 76629 Check Date: 09/04/2018 Vendor: BrowersJ John & Caitlyn Browers RefundFina Refund on overpmt of final UB 9975-0 08/23/2018 45.85 Check Total: 45.85 Check No: 76630 Check Date: 09/04/2018 Vendor: CentraPe Central Pension Fund PP ending 8/17/18 08/23/2018 200.00 Check Total: 200.00 Check No: 76631 Check Date: 09/04/2018 Vendor: CenturyL Century Link August 08/23/2018 58.36 August 08/23/2018 45.10 Check Total: 103.46 Check No: 76632 Check Date: 09/04/2018 Vendor: Cintas Cintas 4009096039 8/28/18 08/28/2018 112.38 4008882028 8/21/18 08/28/2018 110.99 Check Total: 223.37 Check No: 76633 Check Date: 09/04/2018 Vendor: CityRose City of Roseville 0224909 Aug PR1 chgs 08/28/2018 157.58 0224862 Aug Metro INET 08/28/2018 6,273.00 0224909 Aug phone support 08/28/2018 627.80 Check Total: 7,058.38 Check No: 76634 Check Date: 09/04/2018 Vendor: Comcast Comcast 8/20-9/19 8/30-9/19 cable services 08/23/2018 6.28 Check Total: 6.28 Check No: 76635 Check Date: 09/04/2018 Vendor: ComoLube Como -
Refreshing the Biologic Pipeline 2020
news feature Credit: Science Lab / Alamy Stock Photo Refreshing the biologic pipeline 2020 In the absence of face-to-face meetings, FDA and industry implemented regulatory workarounds to maintain drug and biologics approvals. These could be here to stay. John Hodgson OVID-19 might have been expected since 1996) — a small miracle in itself “COVID-19 confronted us with the need to severely impair drug approvals (Fig. 1 and Table 1). to better triage sponsors’ questions,” says Cin 2020. In the event, however, To the usual crop of rare disease and Peter Marks, the director of the Center for industry and regulators delivered a small genetic-niche cancer treatments, 2020 Biologics Evaluation and Research (CBER) miracle. They found workarounds and also added a chimeric antigen receptor at the FDA. “That was perhaps the single surrogate methods of engagement. Starting (CAR)-T cell therapy with a cleaner biggest takeaway from the pandemic related in January 2020, when the outbreak veered manufacturing process and the first to product applications.” Marks says that it westward, the number of face-to face approved blockbuster indication for a became very apparent with some COVID- meetings declined rapidly; by March, small-interfering RNA (siRNA) — the 19-related files that resolving a single they were replaced by Webex and Teams. European Medicines Agency’s (EMA) issue can help a sponsor enormously and (Secure Zoom meeting are to be added registration of the RNA interference accelerate the development cycle. Before this year.) And remarkably, by 31 December, (RNAi) therapy Leqvio (inclisiran) for COVID-19, it was conceivable that a small the US Food and Drug Administration cardiovascular disease. -
Fiserv Cashless Payment Innovations for Merchants, Insurers Receive 2020 Payments Awards
Fiserv Cashless Payment Innovations for Merchants, Insurers Receive 2020 Payments Awards December 18, 2020 Solutions enable cashless payments at the point of sale and remotely Warsaw, Poland, 18 December 2020 – Fiserv, a leading global provider of payments and financial services technology, has won two 2020 Payments Awards thanks to the company’s innovative and pioneering approach to cashless payments. “First and foremost, these awards recognise the work of the entire team, as well as the innovative mindset and courage of our partners. Both awards are not only a source of great pride, but also serve as additional incentive for further growth. I am glad to be able to work with trendsetters shaping the world of cashless payments,” said Krzysztof Polończyk, President of First Data Polska, now Fiserv. The Payments Innovation of the Year Award was presented for the SoftPOS PIN on Mobile solution from Fiserv, a technology developed in conjunction with Visa, Samsung and PayCore. The solution enables cashless payment acceptance by merchants on their own devices, such as smartphones or tablets, for any payment amount and without the need for additional equipment. The solution, which is currently being piloted in Poland, opens up the possibility of increased use of mobile devices as payment terminals worldwide. “The popularity of non-cash payments in Poland continues to grow. We already have over a million terminals in Poland, and connecting smartphones and tablets to this huge network will not only increase the share of cashless transactions, but above all will have a positive impact on the cash flow of merchants, small businesses and service providers,” says Rafał Galiński, Products Development Director at First Data Polska, now Fiserv. -
OSI ETF Trust O'shares U.S
OSI ETF Trust O'Shares U.S. Quality Dividend ETF Schedule of Investments September 30, 2020 (Unaudited) Investments Shares Value ($) Investments Shares Value ($) Rockwell Automation, Inc. 4,146 914,939 COMMON STOCKS - 99.9% 1,828,788 Electronic Equipment, Instruments & Components - 0.1% Aerospace & Defense - 3.7% Amphenol Corp., Class A 6,409 693,902 General Dynamics Corp. 13,436 1,859,946 L3Harris Technologies, Inc. 4,435 753,240 Food & Staples Retailing - 2.5% Lockheed Martin Corp. 35,607 13,647,451 Costco Wholesale Corp. 15,959 5,665,445 Northrop Grumman Corp. 10,932 3,448,937 Walmart, Inc. 55,162 7,717,715 19,709,574 13,383,160 Air Freight & Logistics - 1.8% Food Products - 1.3% CH Robinson Worldwide, Inc. 9,742 995,535 General Mills, Inc. 25,291 1,559,949 Expeditors International of Hershey Co. (The) 7,961 1,141,130 Washington, Inc. 17,449 1,579,484 Hormel Foods Corp. 29,597 1,446,997 United Parcel Service, Inc., Class B 40,608 6,766,511 Kellogg Co. 8,337 538,487 9,341,530 Mondelez International, Inc., Class Banks - 0.5% A 39,472 2,267,666 JPMorgan Chase & Co. 29,156 2,806,848 6,954,229 Health Care Equipment & Supplies - 1.7% Beverages - 4.6% Abbott Laboratories 23,962 2,607,784 Brown-Forman Corp., Class B 11,255 847,727 Medtronic plc 52,777 5,484,586 Coca-Cola Co. (The) 238,082 11,754,108 Stryker Corp. 4,753 990,383 PepsiCo, Inc. 85,663 11,872,892 9,082,753 24,474,727 Health Care Providers & Services - 2.8% Biotechnology - 3.4% Anthem, Inc. -
VIRTUS ZEVENBERGEN INNOVATIVE GROWTH STOCK FUND SCHEDULE of INVESTMENTS (Unaudited) MARCH 31, 2021
VIRTUS ZEVENBERGEN INNOVATIVE GROWTH STOCK FUND SCHEDULE OF INVESTMENTS (Unaudited) MARCH 31, 2021 ($ reported in thousands) Shares Value Shares Value Footnote Legend: (1) Non-income producing. COMMON STOCKS—99.0% Industrials—3.9% Communication Services—9.3% Desktop Metal, Inc. (1) Country Weightings† Coursera, Inc.(1) 7,100 $ 320 Class A 359,800 $ 5,361 (1) Uber Technologies, United States 87% Netflix, Inc. 84,500 44,080 (1) Snap, Inc. Class A(1) 586,650 30,676 Inc. 897,900 48,944 Canada 7 Zillow Group, Inc. 54,305 Brazil 5 Class C(1) 434,335 56,307 Israel 1 Information Technology—43.9% Total 100% 131,383 (1) Coupa Software, Inc. 78,450 19,964 † (1) % of total investments as of March 31, 2021. Consumer Discretionary—25.3% fuboTV, Inc. 315,350 6,976 (1) NVIDIA Corp. 107,000 57,131 Airbnb, Inc. Class A 91,100 17,121 (1) Amazon.com, Inc.(1) 15,200 47,030 Okta, Inc. 235,575 51,928 (1) Paylocity Holding Chegg, Inc. 322,325 27,610 (1) (1) Corp. 110,750 19,916 Chewy, Inc. Class A 340,400 28,835 (1) Fiverr International PayPal Holdings, Inc. 198,850 48,289 Ltd.(1) 27,650 6,005 QUALCOMM, Inc. 204,050 27,055 RingCentral, Inc. Lululemon Athletica, (1) (1) Class A 129,800 38,665 Inc. 41,690 12,787 (1) (1) ServiceNow, Inc. 78,325 39,171 MercadoLibre, Inc. 48,225 70,994 (1) Peloton Interactive, Inc. Shopify, Inc. Class A 78,200 86,528 (1) Snowflake, Inc. Class A 336,850 37,876 (1) Tesla, Inc.(1) 162,740 108,699 Class A 110,700 25,381 Sprout Social, Inc. -
Doctor of Pharmacy Fellowship Program
2021-2022 Doctor of Pharmacy Fellowship Program Accelerate your career with one of our 1-year fellowship programs Transformative Therapies Targeting Cancer Seagen Inc. is a global biotechnology company dedicated to discovering, developing, and commercializing transformative YEARS: In oncology for 23+ years cancer medicines to make a meaningful difference in people’s lives. SIZE: Largest biotechnology company ADCETRIS® (brentuximab vedotin) and PADCEV® (enfortumab vedotin-ejfv) use based in the Pacific Northwest the company’s industry-leading antibody-drug conjugate (ADC) technology. ADCETRIS is approved in certain CD30-expressing lymphomas, and PADCEV is EMPLOYEES: 2,200+ employees approved in certain metastatic urothelial cancers. TUKYSA® (tucatinib), a small mole- worldwide cule tyrosine kinase inhibitor, is approved in certain HER2-positive metastatic breast cancers. The company is headquartered in Seattle, Washington area, with loca- PASSION: Helping people with cancer tions in California, Switzerland and the European Union. Beyond our approved prod- ucts, the company has established a pipeline of novel targeted therapies at various stages of clinical testing. OUR MISSION OUR VALUES To discover, develop, and Passion for helping patients commercialize transformative cancer Revolutionizing therapies for people medicines to make a meaningful living with cancer difference in people’s lives. Integrity Honesty, respect and trust guide us Scientific excellence Premier science empowers our passion We have built a strong Diversity, teamwork, and corporate culture around our mutual respect mission and values. Seagen Shared dedication and diverse embodies an entrepreneurial perspectives drive successful spirit that advances collaborations breakthrough therapies, Innovation which is why we are the Entrepreneurial spirit advances leader in antibody-drug breakthrough therapies conjugate technology. -
FTIF - Franklin Global Growth Fund August 31, 2021
FTIF - Franklin Global Growth Fund August 31, 2021 FTIF - Franklin Global Growth August 31, 2021 Fund Portfolio Holdings The following portfolio data for the Franklin Templeton funds is made available to the public under our Portfolio Holdings Release Policy and is "as of" the date indicated. This portfolio data should not be relied upon as a complete listing of a fund's holdings (or of a fund's top holdings) as information on particular holdings may be withheld if it is in the fund's interest to do so. Additionally, foreign currency forwards are not included in the portfolio data. Instead, the net market value of all currency forward contracts is included in cash and other net assets of the fund. Further, portfolio holdings data of over-the-counter derivative investments such as Credit Default Swaps, Interest Rate Swaps or other Swap contracts list only the name of counterparty to the derivative contract, not the details of the derivative. Complete portfolio data can be found in the semi- and annual financial statements of the fund. Security Security Shares/ Market % of Coupon Maturity Identifier Name Positions Held Value TNA Rate Date G6095L109 APTIV PLC 70,000 $10,653,300 3.09% N/A N/A 045327103 ASPEN TECHNOLOGY INC 58,000 $7,511,000 2.18% N/A N/A BRIGHT HORIZONS FAMILY SOLUTIONS 109194100 49,000 $7,142,240 2.07% N/A N/A INC BROADRIDGE FINANCIAL SOLUTIONS 11133T103 46,000 $7,922,120 2.30% N/A N/A INC 124765108 CAE INC 360,000 $10,394,547 3.01% N/A N/A CHARLES RIVER LABORATORIES 159864107 27,000 $11,984,220 3.47% N/A N/A INTERNATIONAL -
Fintech & Bank
VOLUME 3 | 2018 THE CENTER OF COMMERCE Fintech & Bank FUsionThere Are Certain Things In Life That You Expect To Be Boring. Technology relevant to the consumer,” says Nigel So, banks have stepped up, have started There are Motyer, who heads up First Data’s Direct to “shake off” the old stodgy perceptions Acquiring Business in EMEA and sits and are beginning to innovate in on the Board of Directors at First Data response to consumer needs. Recently, certain things Europe. “Why did PayPal® become so major banks collaborated to create their all-pervasive? Because it was the only own fintech P2P platform called Zelle®, method of payment that you had on which allows account holders to transfer Fintech in life that eBay – and the consumer loved eBay.” cash instantly over apps or online. you expect to Consumers also love a new way to pay Meanwhile, the fintech world is actively their friends and family, via person-to- seizing ground once monopolized by person micropayments. Early versions banks. SoFi® is an online company that Bank Fusion be boring. allowed for easy payments via text provides personal loans, mortgages, messages. Now, person-to-person and student loan refinancing, mostly For example, rice cakes, micropayments live on a platform nearly targeting Millennials.5 GreenSky® offers waiting rooms, stories indistinguishable from social media, a instant loans for home improvements,6 about rocks – and certain no-go zone for banks.4 and Avant® offers loans to consumers things that you hope will with low credit scores.7 be boring like visits to the “Banks, traditionally, were very slow dentist and travel by plane. -
2020 Q1 Mid Cap Growth Factsheet
Mid Cap Growth Strategy | Fact Sheet as of 03/31/2020 Philosophy Chuck Lauber, CFA First National believes 15% Portfolio Manager that active portfolio 10% Chuck has 25 years of management grounded in 5% investment management strong fundamental 0% experience serving a research and adherence -5% majority of that time as a to risk management will -10% Small and Mid Cap Equity add value to our clients' -15% Analyst at Koesten portfolios over full market -20% Hirschmann & Crabtree cycles by limiting volatility -25% Quarter 1 Year 3 Years 5 Years 10 Years and Security Benefit and increasing their Group. He joined First First National Bank (Gross of Fees) returns. First National Bank (Net of Fees) National in August 2006. Russell Midcap Growth Chuck earned his Bachelors in Business Quarter 1 Year 3 Years 5 years 10 Years Strategy Administration from East Composite (Gross of Fees) -21.19% -11.41% 4.91% 4.63% 10.67% Texas State University in Seeks to maximize long- Composite (Net of Fees) -21.37% -12.32% 4.01% 3.78% 9.73% 1987 and his Masters of term total return, by Russell Midcap Growth -20.04% -9.45% 6.53% 5.61% 10.89% Business Administration in identifying mid-cap 1993 at the University of growth companies in a Portfolio Statistics Strategy Benchmark Texas. broad range of economic Weighted Avg. Market Cap $17.63B $17.26B sectors and industries in Median Market Cap $11.81B $7.24B a bottom-up process. We Kurt Spieler, CFA Price/Earnings (ex-neg) 26.0x 23.0x search for companies that Senior Managing Director Price/Book Ratio 4.1x 4.4x have established a & Portfolio Manager Standard Deviation 17.78% 17.43% sustainable competitive Kurt joined First National Beta 1.01 1.00 advantage. -
Download the Digital Magazine At: Firstdata.Com/Connected
VOLUME 3 | 2018 THE CENTER OF COMMERCE the innovators CASE STUDY: 2 QSR Company INFORMATION QSR customer upgrades their fraud COVER detection to enable a new mobile RESULTS: application launch PROBLEM: When this customer launched a new version of their mobile app, they saw fraud spikes that decrease & ANALYTICS called for new tools. 80% in fraud. SOLUTION: The Advanced offering of Fraud Detect was implemented with a machine learning QSR- industry model, a rules engine, and Case 14 SOLUTIONS Manager. First Data also implemented a capability $200K allowing this customer to test the model at saved after fees. DATA AT THE SPEED OF COMMERCE different scoring thresholds. The innovators Building the new retail frontier. 19 bonus: SPECIAL section Unlocking Merchant Innovation Using machine learning to combat fraud. Shopping is about to get interesting. 8 Mobility Hits Its Groove 44 Fintech & Bank Fusion 10 Outsmarting Fraudsters 47 The Power of Partnerships 12 Rewards Revolution 48 Payments Everywhere 35 The New Big Data 50 Gen-Z Rising 39 Food for Thought 54 Financial Literacy in the Gig Economy 40 Tackling the Pay Gap download the digital magazine At: FirstData.com/Connected Not sure about you, but our dogs are always finding innovative new ways to get our attention. Through this issue of Connected, we take a look at how partnerships, changing consumer landscapes, and fraud breakthroughs are fetching innovative ideas across industries – Labonardo da Vinci and Thomas Pugison would be so pleased. As you’re reading, keep an eye out for the pooches and pups hidden throughout the pages and count them up. -
Ensemble Capital Management Quarterly Letter
ENSEMBLE CAPITAL MANAGEMENT QUARTERLY LETTER First Quarter 2021 The performance of securities mentioned within this letter refers to how the security performed in the market and does not reflect the performance attributed to the core equity portfolio. Please see the chart at the end of letter, which reflects the full list of contributors and detractors based on each security's weighting within the core equity portfolio. For a copy of Ensemble Capital’s equity strategy performance track record, please email a request to [email protected]. It has now been a full year since global markets were shaken by COVID. If someone fell into a deep sleep on February 19, 2020 and woke up on March 31, 2021, they’d see the S&P 500 was up 19.72% since they last checked their portfolio. By historical standards, a great return in just over thirteen months! “Not much must have happened,” they’d think, “Oh well, back to bed.” For the rest of us, we know the last year was anything but sleepy. Beyond the direct impacts of COVID, which we’ve covered in previous letters, the pandemic accelerated secular trends such as video gaming, remote working, and e-commerce. As we begin lapping those impacts, the market is wrestling with what comes next for companies that prospered or struggled during COVID. The Goldman Sachs “reopen basket,” which consists of 35 US-listed stocks that Goldman believes stand to benefit the most in a reopening scenario, was up 22.0% this quarter. In contrast, the Goldman Sachs “US Stay at Home Basket” of stocks was down 2.4%.