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Prostate Cancer in Focus
PROSTATE CANCER IN FOCUS Current Developments in the Management of Prostate Cancer Section Editor: Andrew J. Armstrong, MD Prostate Cancer Prostate PSMA-Targeted Therapy in Prostate Cancer Scott T. Tagawa, MD, MS Professor of Medicine and Urology Weill Cornell Medicine New York, New York H&O What is prostate-specific membrane agent such as a monoclonal antibody might be able to antigen (PSMA), and what makes it a good target target a tumor without binding to other PSMA-positive for the treatment of prostate cancer? sites owing to its large size and physical inability to reach luminal sites of expression that are separated from the ST PSMA is a cell surface antigen that is expressed to vasculature by tight junctions. a limited degree on certain normal cells in the body but generally is highly overexpressed in the setting of prostate H&O How is PSMA positivity established? cancer. Normal cells that express PSMA are located in the prostate, salivary, and lacrimal glands; the proximal part ST Imaging and biopsy are the main ways to establish of the small intestine; the proximal renal tubules; and PSMA positivity. Multiple imaging modalities are avail- some ganglia. In the setting of prostate cancer, PSMA able worldwide. The agent indium In 111 capromab expression generally increases along with the cancer grade, pendetide (ProstaScint) has been approved for years in and it also increases following hormonal therapy. In addi- the United States, and the US Food and Drug Adminis- tion, PSMA expression tends to be higher in metastatic tration (FDA) approved the use of gallium Ga 68 PSMA- sites than in primary tumors. -
Match Group, Inc. (Exact Name of Registrant As Specified in Its Charter)
As filed with the Securities and Exchange Commission on August 8, 2019 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☑ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended June 30, 2019 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from__________to__________ Commission File No. 001-37636 Match Group, Inc. (Exact name of registrant as specified in its charter) Delaware 26-4278917 (State or other jurisdiction of (I.R.S. Employer incorporation or organization) Identification No.) 8750 North Central Expressway, Suite 1400 , Dallas , Texas 75231 (Address of registrant’s principal executive offices) ( 214 ) 576-9352 (Registrant’s telephone number, including area code) Securities registered pursuant to Section 12(b) of the Act: Title of each class Trading Symbol Name of exchange on which registered Common Stock, par value $0.001 MTCH The Nasdaq Stock Market LLC (Nasdaq Global Select Market) Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ☑ No ☐ Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). -
2021 Honored Companies Please Join Us As We Give Special Recognition and Honor S&P 500 and F1000 Companies with at Least 35% of Board Seats Held by Women
Cipriani 42nd St | November 10, 2021 | 7:30 AM-11:00 AM 2021 Honored Companies Please join us as we give special recognition and honor S&P 500 and F1000 companies with at least 35% of board seats held by women. 50% + AMN Healthcare General Motors Co. Sally Beauty Holdings, Inc. Autodesk, Inc. Hasbro, Inc. Schnitzer Steel Industries, Inc. Bed, Bath & Beyond, Inc. Hawaiian Electric Industries, Inc. Science Applications International Corporation (SAIC) Best Buy Companies Inc. Healthpeak Properties, Inc. Steelcase Inc. Big Lots Inc. Herman Miller, Inc. Summit Materials, Inc. Bright Horizons Family Solutions, Inc. HNI Corporation Tapestry, Inc. Caleres, Inc. J.Crew Group, Inc. Thrivent Financial Casey’s General Stores, Inc. L Brands, Inc. TIAA Celanese Corporation Micron Technology Inc Tiffany & Co. Chico’s Fas, Inc. Navient Corporation ULTA Beauty Inc. Citi Omnicom Group Inc. ViacomCBS Inc. Coty Inc. PC Connection, Inc. Welltower Inc. DaVita Pitney Bowes, Inc. Western Digital Corporation EQT Corporation The Procter & Gamble Co. Williams-Sonoma, Inc. Etsy, Inc. The Progressive Corporation 40% + Abercrombie & Fitch Co. Genworth Financial The ODP Corporation ABM Industries, Inc. Globe Life Inc. Penn Mutual Accenture The Goldman Sachs Group, Inc. Phillips 66 Company AES Corporation Groupon Inc. Principal Financial Group Inc. Afliated Managers Group (AMG) H & R Block, Inc. PROG Holdings, Inc. AGNC Investment Corp. The Hershey Companies Quest Diagnostics Inc. Alliant Energy Hewlett Packard Enterprise RR Donnelley & Sons Co. Amazon.com, Inc. Hill-Rom Holdings Inc. Reinsurance Group Of America, Inc. American Water Works, Inc. Hilton Worldwide Holdings, Inc. Reliance Steel and Aluminum Co. Amica Mutual Insurance Company HP Inc. -
Parker Review
Ethnic Diversity Enriching Business Leadership An update report from The Parker Review Sir John Parker The Parker Review Committee 5 February 2020 Principal Sponsor Members of the Steering Committee Chair: Sir John Parker GBE, FREng Co-Chair: David Tyler Contents Members: Dr Doyin Atewologun Sanjay Bhandari Helen Mahy CBE Foreword by Sir John Parker 2 Sir Kenneth Olisa OBE Foreword by the Secretary of State 6 Trevor Phillips OBE Message from EY 8 Tom Shropshire Vision and Mission Statement 10 Yvonne Thompson CBE Professor Susan Vinnicombe CBE Current Profile of FTSE 350 Boards 14 Matthew Percival FRC/Cranfield Research on Ethnic Diversity Reporting 36 Arun Batra OBE Parker Review Recommendations 58 Bilal Raja Kirstie Wright Company Success Stories 62 Closing Word from Sir Jon Thompson 65 Observers Biographies 66 Sanu de Lima, Itiola Durojaiye, Katie Leinweber Appendix — The Directors’ Resource Toolkit 72 Department for Business, Energy & Industrial Strategy Thanks to our contributors during the year and to this report Oliver Cover Alex Diggins Neil Golborne Orla Pettigrew Sonam Patel Zaheer Ahmad MBE Rachel Sadka Simon Feeke Key advisors and contributors to this report: Simon Manterfield Dr Manjari Prashar Dr Fatima Tresh Latika Shah ® At the heart of our success lies the performance 2. Recognising the changes and growing talent of our many great companies, many of them listed pool of ethnically diverse candidates in our in the FTSE 100 and FTSE 250. There is no doubt home and overseas markets which will influence that one reason we have been able to punch recruitment patterns for years to come above our weight as a medium-sized country is the talent and inventiveness of our business leaders Whilst we have made great strides in bringing and our skilled people. -
Match Group Stock Pitch
Match Group Stock Pitch Analyst: James Campion First Things First Who in this room has used Tinder, Hinge, or another dating app? 2 Disclaimer I made these slides in 48 hours and took a lot of screenshots. You are allowed to take screenshots and make non-aesthetically pleasing slides for Investment Club (content matters more), but for SIBC and your full-time job do not do this! Thesis: 1. The Match Group currently holds a monopoly on the online- dating market, which is benefitting from changing social standards and increased connectivity 2. The Match Group has developed a diverse portfolio of brands, both through organic and inorganic methods, which enables them to serve customers of different ages and demographics 3. The Company’s combination of operating leverage and scale have led to expanding margins, driving a cash flow machine that should return cash to shareholders after the IAC spin-off 4. Valuation has gotten “frothy” but I still there is value as a long- term shareholder 4 Industry Focus Why online dating? More Couples Are Swiping Right ▸ In 2018, seven of the 53 couples profiled in the Vows column met on dating apps. ▸ And in the Times’ more populous Wedding Announcements section, 93 out of some 1,000 couples profiled this year met on dating apps ▸ The year before, 71 couples whose weddings were announced by the Times met on dating apps. Thanks to former NDIC President & VP, Dan McMurtie & Alex Draime for their report on the 6 dating market! Why Would Anyone Date Online?! ▸ Just a crazy thought, but what if in 10 years we think it is crazy that anyone met in person ▸ There are almost 8 billion people in the world, and we each get to meet about ~10,000 – And you’re telling me that you found your soulmate?! ▸ In the future, it might make more sense for machine learning trained algorithms to pair couples based on a number of different factors – There are just so many things it takes so long to tell someone about yourself (i.e. -
Dual Class Companies List
Dual Class Companies List The following US-incorporated, Russell 3000 companies have at least two outstanding classes of common stock with unequal voting rights as of March 2017. Primary Company Name Unequal Voting Structure Ticker Class A: 1 vote per share 1-800-FLOWERS.COM FLWS Class B: 10 votes per share Class A Common: 1 A. O. Smith AOS Common: 1/10 Time-phased voting: Aflac AFL 1 vote per share until stock held for 4 years, then 10 votes per share Class A: 1 Albany International AIN Class B: 10 Class A: 1 Alphabet GOOGL Class B: 10 Class C: no votes Class A: 1 AMC Entertainment Holdings AMC Class B: 3 Class A: 1; elects 25% of board AMC Networks AMCX Class B: 10; elects 75% of board Class A: 1 Ameresco AMRC Class B: 5 Class A: 1 American Homes 4 Rent AMH Class B: 50 Class A: 1/10; elects 25% of board American Software AMSWA Class B: 1; elects 75% of board Class A: 1 AppFolio APPF Class B: 10 Primary Company Name Unequal Voting Structure Ticker Class A: 1 Apptio APTI Class B: 10 Class A: no votes Artesian Resources ARTNA Class B: 1 Class A: 1 Artisan Partners Asset Management APAM Class B: 5 Class A: 1 Ascent Capital Group ASCMA Class B: 10 Class A: 1 Associated Capital Group AC Class B: 10 Common: 1 Astronics ATRO Class B Common: 10 Class A: 1 Baldwin & Lyons BWINB Class B: no votes Class A: 1 Bel Fuse BELFB Class B: no votes Class A: 1 Berkshire Hathaway BRK.B Class B: 1/10,000 Class A: 1 BGC Partners BGCP Class B: 10 Class A: 1/10 Bio-Rad Laboratories BIO Class B: 1 Class A: 1 Box BOX Class B: 10 Class A Nonvoting: no votes Brady -
Refreshing the Biologic Pipeline 2020
news feature Credit: Science Lab / Alamy Stock Photo Refreshing the biologic pipeline 2020 In the absence of face-to-face meetings, FDA and industry implemented regulatory workarounds to maintain drug and biologics approvals. These could be here to stay. John Hodgson OVID-19 might have been expected since 1996) — a small miracle in itself “COVID-19 confronted us with the need to severely impair drug approvals (Fig. 1 and Table 1). to better triage sponsors’ questions,” says Cin 2020. In the event, however, To the usual crop of rare disease and Peter Marks, the director of the Center for industry and regulators delivered a small genetic-niche cancer treatments, 2020 Biologics Evaluation and Research (CBER) miracle. They found workarounds and also added a chimeric antigen receptor at the FDA. “That was perhaps the single surrogate methods of engagement. Starting (CAR)-T cell therapy with a cleaner biggest takeaway from the pandemic related in January 2020, when the outbreak veered manufacturing process and the first to product applications.” Marks says that it westward, the number of face-to face approved blockbuster indication for a became very apparent with some COVID- meetings declined rapidly; by March, small-interfering RNA (siRNA) — the 19-related files that resolving a single they were replaced by Webex and Teams. European Medicines Agency’s (EMA) issue can help a sponsor enormously and (Secure Zoom meeting are to be added registration of the RNA interference accelerate the development cycle. Before this year.) And remarkably, by 31 December, (RNAi) therapy Leqvio (inclisiran) for COVID-19, it was conceivable that a small the US Food and Drug Administration cardiovascular disease. -
GTC-ONE-Minute-Brief-117.Pdf
Equity | Currencies & Commodities | Corporate & Global Economic News | Economic Calendar 16 September 2020 Economic and political news Key indices The National Economic Development and Labour Council (Nedlac) As at 15 1 Day 1 D % WTD % MTD % Prev. month YTD % chaired by President Cyril Ramaphosa has agreed to an economic recovery plan for South Africa (SA) and a social compact to mobilise Sept 2020 Chg Chg Chg Chg % Chg Chg JSE All Share 56130.78 -196.27 -0.35 0.08 1.18 -0.44 -1.67 funding to address Eskom's financial crisis. (ZAR) The Matjhabeng Municipality in Free State has agreed to hand over 139 JSE Top 40 (ZAR) 51795.70 -181.12 -0.35 0.16 1.11 -0.28 1.93 farms worth about ZAR2.5bn belonging to the administrative region as FTSE 100 (GBP) 6105.54 79.29 1.32 1.22 2.38 1.12 -19.05 security on the ZAR3.4bn debt it owes to Eskom. DAX 30 (EUR) 13217.67 24.01 0.18 0.11 2.10 5.13 -0.24 According to the Automobile Association (AA), petrol price in SA will CAC 40 (EUR) 5067.93 16.05 0.32 0.67 2.44 3.42 -15.22 drop by between 26 cents and 36 cents per litre and diesel by 88 cents S&P 500 (USD) 3401.20 17.66 0.52 1.80 -2.83 7.01 5.27 per litre in October. Nasdaq 11190.32 133.67 1.21 3.10 -4.97 9.59 24.72 Democratic Alliance (DA) leader John Steenhuisen has requested Composite (USD) President Cyril Ramaphosa to end the curfew imposed in a bid to curb DJIA (USD) 27995.60 2.27 0.01 1.19 -1.53 7.57 -1.90 MSCI Emerging the spread of COVID-19, open all sectors of the South African economy, 1112.62 8.35 0.76 1.91 1.01 2.09 -0.18 and allow for international travel and reintroduce a normal school week. -
Portfolio Activity Q3 2018
Portfolio Activity Q3 2018 By Louis S. Foxwell, Research Analyst The following discussion mentions stocks that are widely — but not universally — held by clients of Horan Capital Management. Client portfolios are customized, so this commentary may or may not be directly applicable to any given client or account. Our intention is to provide general insight into portfolio holdings and into our overall approach and to highlight situations of interest, both positive and negative. The mention of any stock is neither advice nor a solicitation to buy or sell any particular investment and our opinions regarding securities are subject to change without notice. Investing involves risk of loss. See the legal disclosures at the end of this publication and on our website for more information. BUYS Booking Holdings Inc. (BKNG) Booking Holdings (formerly known as Priceline) operates as an Online Travel Agency (“OTA”). The company’s online platforms facilitate business transactions between travelers and hotels/airlines/rental car services. In most cases, Booking acts as a platform and receives a commission for lending its network to travelers and businesses. In other cases, Booking will act as the facilitator of payments, buying rooms in bulk and selling them individually at a profit. The company also generates advertising revenue on select platforms. Most of Booking’s revenue is generated in Europe where boutique hotels are commonplace and there is very little consolidation in the hotel industry. This lack of consolidation makes smaller hotels dependent on Booking’s services, giving the company a wide economic moat. The company has a pristine balance sheet, with net cash and investments. -
Match Group Business Overview
Business Overview May 2020 Confidential – For Internal Use Only Safe Harbor Disclosure and Definitions This presentation contains forward-looking statements. The use of words such as “anticipates,” “estimates,” “expects,” “plans” and “believes,” among others, generally identify forward-looking statements. These forward-looking statements include, among others, statements relating to: Match Group’s future financial performance, Match Group’s business prospects and strategy, anticipated trends, the completion of the separation of Match Group from IAC/InterActiveCorp, and other similar matters. These forward-looking statements are based on management’s current expectations and assumptions about future events, which are inherently subject to uncertainties, risks and changes in circumstances that are difficult to predict. Actual results could differ materially from those contained in these forward-looking statements for a variety of reasons, including, among others: competition, our ability to maintain user rates on our higher monetizing dating products, our ability to attract users to our dating products through cost-effective marketing and related efforts, foreign currency exchange rate fluctuations, our ability to distribute our dating products through third parties and offset related fees, the integrity and scalability of our systems and infrastructure (and those of third parties) and our ability to adapt ours to changes in a timely and cost-effective manner, our ability to protect our systems from cyberattacks and to protect personal and -
VIRTUS ZEVENBERGEN INNOVATIVE GROWTH STOCK FUND SCHEDULE of INVESTMENTS (Unaudited) MARCH 31, 2021
VIRTUS ZEVENBERGEN INNOVATIVE GROWTH STOCK FUND SCHEDULE OF INVESTMENTS (Unaudited) MARCH 31, 2021 ($ reported in thousands) Shares Value Shares Value Footnote Legend: (1) Non-income producing. COMMON STOCKS—99.0% Industrials—3.9% Communication Services—9.3% Desktop Metal, Inc. (1) Country Weightings† Coursera, Inc.(1) 7,100 $ 320 Class A 359,800 $ 5,361 (1) Uber Technologies, United States 87% Netflix, Inc. 84,500 44,080 (1) Snap, Inc. Class A(1) 586,650 30,676 Inc. 897,900 48,944 Canada 7 Zillow Group, Inc. 54,305 Brazil 5 Class C(1) 434,335 56,307 Israel 1 Information Technology—43.9% Total 100% 131,383 (1) Coupa Software, Inc. 78,450 19,964 † (1) % of total investments as of March 31, 2021. Consumer Discretionary—25.3% fuboTV, Inc. 315,350 6,976 (1) NVIDIA Corp. 107,000 57,131 Airbnb, Inc. Class A 91,100 17,121 (1) Amazon.com, Inc.(1) 15,200 47,030 Okta, Inc. 235,575 51,928 (1) Paylocity Holding Chegg, Inc. 322,325 27,610 (1) (1) Corp. 110,750 19,916 Chewy, Inc. Class A 340,400 28,835 (1) Fiverr International PayPal Holdings, Inc. 198,850 48,289 Ltd.(1) 27,650 6,005 QUALCOMM, Inc. 204,050 27,055 RingCentral, Inc. Lululemon Athletica, (1) (1) Class A 129,800 38,665 Inc. 41,690 12,787 (1) (1) ServiceNow, Inc. 78,325 39,171 MercadoLibre, Inc. 48,225 70,994 (1) Peloton Interactive, Inc. Shopify, Inc. Class A 78,200 86,528 (1) Snowflake, Inc. Class A 336,850 37,876 (1) Tesla, Inc.(1) 162,740 108,699 Class A 110,700 25,381 Sprout Social, Inc. -
Annex 1: Parker Review Survey Results As at 2 November 2020
Annex 1: Parker Review survey results as at 2 November 2020 The data included in this table is a representation of the survey results as at 2 November 2020, which were self-declared by the FTSE 100 companies. As at March 2021, a further seven FTSE 100 companies have appointed directors from a minority ethnic group, effective in the early months of this year. These companies have been identified through an * in the table below. 3 3 4 4 2 2 Company Company 1 1 (source: BoardEx) Met Not Met Did Not Submit Data Respond Not Did Met Not Met Did Not Submit Data Respond Not Did 1 Admiral Group PLC a 27 Hargreaves Lansdown PLC a 2 Anglo American PLC a 28 Hikma Pharmaceuticals PLC a 3 Antofagasta PLC a 29 HSBC Holdings PLC a InterContinental Hotels 30 a 4 AstraZeneca PLC a Group PLC 5 Avast PLC a 31 Intermediate Capital Group PLC a 6 Aveva PLC a 32 Intertek Group PLC a 7 B&M European Value Retail S.A. a 33 J Sainsbury PLC a 8 Barclays PLC a 34 Johnson Matthey PLC a 9 Barratt Developments PLC a 35 Kingfisher PLC a 10 Berkeley Group Holdings PLC a 36 Legal & General Group PLC a 11 BHP Group PLC a 37 Lloyds Banking Group PLC a 12 BP PLC a 38 Melrose Industries PLC a 13 British American Tobacco PLC a 39 Mondi PLC a 14 British Land Company PLC a 40 National Grid PLC a 15 BT Group PLC a 41 NatWest Group PLC a 16 Bunzl PLC a 42 Ocado Group PLC a 17 Burberry Group PLC a 43 Pearson PLC a 18 Coca-Cola HBC AG a 44 Pennon Group PLC a 19 Compass Group PLC a 45 Phoenix Group Holdings PLC a 20 Diageo PLC a 46 Polymetal International PLC a 21 Experian PLC a 47