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Variable Skeletal Anatomical Features of Acromegaly in the Skull and Craniocervical Junction

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Variable Skeletal Anatomical Features of Acromegaly in the Skull and Craniocervical Junction Case report Acta Medica Academica 2017;46(2):162-168 DOI: 10.5644/ama2006-124.201 Variable skeletal anatomical features of acromegaly in the skull and craniocervical junction Maria Piagkou1, Othon Manolakos1, Theodore Troupis1, Nikolaos Lazaridis2, Konstantinos Laios1, Alexandros Samolis1, Konstantinos Natsis2 1Department of Anatomy, Medical School Objective. This study adds important information regarding the mor- Faculty of Health Sciences, National and phological alterations caused by growth hormone hypersecretion in Kapodistrian University of Athens the skull and craniocervical junction (CCJ). A variably asymmet- 2Department of Anatomy and Surgical ric skull due to acromegaly coexists with expansion of the paranasal Anatomy, Medical School, Faculty sinuses and multiple Wormian bones. Case report. A pathologically of Health Sciences, Aristotle University asymmetric dry skull of a European male, aged 38 years at death, with of Thessaloniki, Thessaloniki, Greece cranial vault and skull base thickening is described. The extensive pa- ranasal sinus pneumatization caused a generalized thinning of the Correspondence: bony walls. The sphenoid sinus expanded intraorbitally, leading to sel- [email protected] la enlargement. The orbital asymmetry coexisted with platybasia and Tel.: + 302 10 746 2427 hypoplasia of the occipital condyles and the odontoid process. Facial Fax.: + 302 10 746 2398 skeleton elongation and mandibular overgrowth were combined with prognathism, malocclusion and overbite. Conclusion. Skull and CCJ Received: 16 August 2017 alterations are of paramount importance when selecting the surgical Accepted: 30 October 2017 approach, if surgery is indicated. Consecutively, detailed preoperative evaluation and planning is essential. During surgery, skilled and expe- Key words: Acromegaly ■ Skull base ■ rienced neurosurgeons recognize anatomical landmarks, use neuro- Craniocervical junction ■ Paranasal sinuses navigation and micro-instrumentation in order to remain on the mid- ■ Wormian bones. line avoiding any potential lethal vascular injury. Introduction thickening and the joint space narrowing share many features with osteoarthritis (2). Acromegaly is a chronic endocrinopathy Pathognomonic signs in the neurocranium caused by growth hormone (GH) hyperse- include cranial vault thickening, frontal cretion and stimulation of periosteal new skull bossing, prominent supraorbital ridges bone formation, bone remodeling (1) and and large external occipital protuberance. In resorption (2). The subsequent articular the viscerocranium, nasal bone hypertro- chondrocyte replication and hyperfunction phy, maxillary widening, mandibular over- lead to cartilage thickening, joint widen- growth and prognathism with malocclusion ing and hypermobility (3). The periarticu- and overbite may occur (4). lar structures begin to grow and synovial The current report emphasizes the mor- hypertrophy further exacerbates the ab- phological and morphometric features of normal mechanical loading of the joints. acromegaly in the skull and CCJ. These al- Disease progression ends with fibrocarti- terations are of special neurosurgical interest lage calcification and osteophyte formation. and demand a detailed preoperative evalua- In advanced cases, the articular cartilage tion and planning. During surgery, the use 162 Copyright © 2017 by the Academy of Sciences and Arts of Bosnia and Herzegovina. Maria Piagkou et al.: Skull and craniocervical junction in acromegaly of anatomical landmarks, neuronavigation The most impressive intracranialfinding and micro-instrumentation is necessary. was the excessive enlargement of the sella turcica (anteroposterior diameter 33.8 mm) and its porosity due to a pituitary adenoma, Case report and the consequent extreme sphenoid si- A pathologically asymmetric skull, with en- nus expansion. The deep and wide pituitary larged paranasal sinuses was found among fossa was perforated by numerous minute 440 European adult human skulls from the apertures. The thickness and density of the osseous collections of the Department of outer and inner tables of the skull were de- Anatomy of the National and Kapodistrian creased due to the over-pneumatization and University (Athens) and the Department of expansion of the frontal sinus. Remarkable Anatomy and Surgical Anatomy of Aristo- posterior cranial fossa side asymmetry was tle University (Thessaloniki). The megalo- easily identified (Figure 1A). The massive cephalic skull belonged to a European male periorbital expansion of the paranasal sinus- aged 38 years at death, with a known history es formed asymmetric orbital cavities and of acromegaly, according to his medical re- particularly pronounced supraorbital ridges cords. The male subject was a body dona- bilaterally, associated with facial skeleton tor, after giving written informed consent, elongation. The maxillary sinuses extended before his death. The extensive paranasal to the palate and the alveolar process (Figure sinuses pneumatization resulted in thinning 1B). Fifty-two Wormian bones (WBs) had of the bony walls, and thickening of the cra- developed from extra ossification centers nial vault and skull base. The anterior crani- within the cranium, 34 of them extracrani- al fossa was shallower than usual due to the ally, 12 intracranially and 6 intraorbitally considerable expansion of the frontal sinus. (Table 1). Figure 1A. Posterior cranial fossa side asymmetry indicated by the black dotted lines on the petrous bone crest. The asterisk (*) indicates sella turcica enlargement and the double asterisks show extensive frontal sinus pneu- matization, FM – foramen magnum, L-left side and R-right side. B. Black arrows indicate the particularly pro- nounced supraorbital ridges. Orbital cavity asymmetry is indicated by the dotted vertical lines. 163 Acta Medica Academica 2017;46:162-168 Table 1 Topographical distribution and frequency of Wormian bones according to side Side Wormian bones’ positions Number Right Left Bilaterally Extracranially Lambdoid suture - - 11 11 Coronal suture - - 12 12 Metopic suture - - 1 1 Zygomatomaxillary suture 2 - - 2 Sphenofrontal suture 2 - - 2 Frontozygomatic suture 1 - - 1 Parietomastoid suture 1 - - 1 Occipitomastoid suture 1 1 - 2 Squamosal suture - 1 - 1 Pterion - 1 - 1 Intraorbitally Frontal bone - 1 - 1 Sphenofrontal suture 5 - - 5 Intracranially Asterion - 1 - 1 Sphenoid bone - 8 8 Frontal bone - 2 - 2 Coronal suture 1 - 1 Total 13 7 32 52 Skull base flattening (platybasia) was both sides. This way the depth was measured detected, taking into consideration the in- bilaterally taking into consideration the creased basal angle (159o) formed between most anterior, middle and posterior points the clival plane and the sphenoid bone of the FM rim, known as the prosthion, FM (normal range 121-148o) (2). The wider middle and opisthion respectively (5). The basal angle in the current case confirms the relative values were 37.98, 37.01 and 38.91 basilar impression. The foramen magnum mm on the left side and 32.87, 32.72 and (FM), irregular in shape, was surrounded 32.94 mm on the right side (Figures 2C, D). by abnormal protuberances of spongy bone The dominance off the left hemicrani- around the right and left occipital condyles um was confirmed. The length and width (OCs) and the posterior rim of the FM. The of the right OC were 29.07 mm and 21.88 mastoid processes were large and bulky and mm, while those of the left were 28.25 mm the external occipital protuberance was ex- and 22.35 mm, respectively. The OCs were tremely prominent (bathrocephaly skull) hypoplastic and completely flattened. New (Figure 2A). Marked side asymmetry was bone formation along the OC margin and observed in the middle and posterior crani- the superior articular facets of the atlas was al fossae. The posterior fossa was filled with detected. Changes of the normal contour dental impression (Figure 2B) which was were accompanied by widening and flat- later bisected along the midline and an addi- tening of the articular facets. An increased tional 0.5 cm thick slice was removed from concavity existed on the right inferior ar- 164 Maria Piagkou et al.: Skull and craniocervical junction in acromegaly Figure 2A Spongy bone around the right and left occipital condyles (ROC and LOC) and the posterior foramen magnum (FM) rim (arrows). Extremely prominent mastoid processes (MP) and external occipital protuberance (EOP), PP- paracondylar process. B. Posterior fossa filled with dental impression. C, D Left and right half of the impression. Depth measurements at prosthion-Pr, opisthion-Op and the midline of the FM to the superior sur- face of the impression. Figure 3A The superior articular facets of the atlas (SAF) and vertebral artery groove (VAG). B. The asymmetric in- ferior articular facets of the atlas (IAF), arrow indicates right more concave SAF. C. Hypoplastic odontoid process of the axis (arrow), osteophyte formation and asymmetric SAF bilaterally. D. E. The atlanto-axial joint, C1- atlas, and C2- axis vertebra. Axis vertebral body overgrowth. F. Increased mandibular rami vertical diameter (height-h) and anteroposterior diameter (width-w). G. Periodontal disease inflammation (yellow asterisk) and mandibular incisors enamel hypoplasia (white arrows). 165 Acta Medica Academica 2017;46:162-168 ticular facets of the atlas (Figures 3A, B). noma may cause GH hypersecretion in 90% The atypical OCs, in combination with the of cases, while in the remaining 10%, tumors odontoid process hypoplasia and its slight of the pancreas, lungs
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