Makers of Modern Biomedicine: a Register
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The Best Way to Assess the Degree of Civilization of Any Society Is To
ALC037 Alcohol etc. (Scotland) Bill Forrester Cockburn Children and a Civilized Scottish Society The best way to assess the degree of civilization of any society is to examine the quality of care which that society provides for the health, welfare and education of its children. In order to achieve optimal child health, it is imperative that the mothers are healthy, understand the needs of their unborn and newborn children and have the appropriate environment for the safe delivery and rearing of their children within a supportive family and community. In Scotland increasing abuse of alcohol and other drugs has placed a large number of children at risk of poor health and born to fail. In this essay I shall concentrate on the risks to the unborn child and the infant after birth. Alcohol damage before birth Probably the first relevant scientific observations were made by Sullivan in 1899. He examined the results of 600 pregnancies of 120 alcoholic women in a Liverpool prison population and found that the infant mortality and stillbirth rate was two and a half times that of their non-alcoholic female relatives. He also showed that the forced abstinence of imprisonment improved the pregnancy outcome. There was parliamentary comment in the UK at that time but little further scientific evidence until the report from Lemoine et al in 1969 which described 127 children with characteristic facial abnormalities and poor growth. The same features were recognised in North America and Canada in the early 1970’s. Since then many other countries including Scotland have identified the problems now known as the fetal alcohol spectrum disorder (FASD) in the infants of mothers drinking alcohol during pregnancy. -
The Epistemology of Evidence in Cognitive Neuroscience1
To appear in In R. Skipper Jr., C. Allen, R. A. Ankeny, C. F. Craver, L. Darden, G. Mikkelson, and R. Richardson (eds.), Philosophy and the Life Sciences: A Reader. Cambridge, MA: MIT Press. The Epistemology of Evidence in Cognitive Neuroscience1 William Bechtel Department of Philosophy and Science Studies University of California, San Diego 1. The Epistemology of Evidence It is no secret that scientists argue. They argue about theories. But even more, they argue about the evidence for theories. Is the evidence itself trustworthy? This is a bit surprising from the perspective of traditional empiricist accounts of scientific methodology according to which the evidence for scientific theories stems from observation, especially observation with the naked eye. These accounts portray the testing of scientific theories as a matter of comparing the predictions of the theory with the data generated by these observations, which are taken to provide an objective link to reality. One lesson philosophers of science have learned in the last 40 years is that even observation with the naked eye is not as epistemically straightforward as was once assumed. What one is able to see depends upon one’s training: a novice looking through a microscope may fail to recognize the neuron and its processes (Hanson, 1958; Kuhn, 1962/1970).2 But a second lesson is only beginning to be appreciated: evidence in science is often not procured through simple observations with the naked eye, but observations mediated by complex instruments and sophisticated research techniques. What is most important, epistemically, about these techniques is that they often radically alter the phenomena under investigation. -
Royal College of Paediatrics and Child Health British Paediatric Surveillance Unit
Royal College of Paediatrics and Child Health British Paediatric Surveillance Unit 14th Annual Report 1999/2000 The British Paediatric Surveillance Unit always welcomes invitations to give talks describing the work of the Unit and makes every effort to respond to these positively. Enquiries should be directed to our office. The Unit positively encourages recipients to copy and circulate this report to colleagues, junior staff and medical students. Additional copies are available from our office, to which any enquiries should be addressed. Published September 2000 by the: British Paediatric Surveillance Unit A unit within the Research Division of the Royal College of Paediatrics and Child Health 50 Hallam Street London W1W 6DE Telephone: 44 (0) 20 7307 5680 Facsimile: 44 (0) 20 7307 5690 E-mail: [email protected] Registered Charity No. 1057744 ISBN 1 900954 48 6 © British Paediatric Surveillance Unit British Paediatric Surveillance Unit - 14 Annual Report 1999-2000 Compiled and edited by Richard Lynn, Angus Nicoll, Jugnoo Rahi and Chris Verity Membership of Executive Committee 1999/2000 Dr Christopher Verity Chairman Dr Angus Clarke Co-opted Professor Richard Cooke Royal College of Paediatrics and Child Health Research Division Dr Patricia Hamilton Co-opted Professor Peter Kearney Faculty of Paediatrics, Royal College of Physicians of Ireland Dr Jugnoo Rahi Medical Adviser Dr Ian Jones Scottish Centre for Infection and Environmental Health Dr Christopher Kelnar Co-opted Dr Gabrielle Laing Co-opted Mr Richard Lynn Scientific Co-ordinator -
Richard Gregory Pri- 1970 He Moved to the University of Bristol, Where He 19 Marily from His Small 1966 Masterpiece Eye and Brain Remained for the Rest of His Career
1 2 3 4 5 6 7 8 9 Obituary 10 11 ALFRED H. FUCHS, EDITOR 12 Bowdoin College 13 14 15 16 17 RICHARD LANGTON GREGORy (1923–2010) 18 19 20 21 BRUCE BRIDGEMAN 22 University of California, Santa Cruz 23 A giant among cognitive scientists, Richard L. Gregory died on May 17th at the age 24 of 86. While most of us remember him for his pioneering work in perception, he 25 had many other interests and accomplishments as well. Though I knew him only 26 late in his life, he always had a spark of boyish curiosity and enthusiasm. Gregory 27 had a way of cocking his head and looking down at his conversation partners; with 28 his height, he looked down at almost everyone, literally but never figuratively. He 29 must have been born tall—it’s impossible to imagine him any other way. 30 Gregory was born into an academic family. His father Christopher was the first 31 director of the University of London Observatory, and he attended a public school 32 (in North America, a private school). His education was interrupted by WWII, 33 during which he served in the signals branch of the Royal Air Force. Continuing on 34 the academic fast track, in 1947 he entered Downing College, Cambridge, studying 35 philosophy and experimental psychology, tutored by Bertrand Russell in the small 36 world of British academia at the time. After earning his degree in 1950, he stayed 37 in Cambridge to work at the Medical Research Council applied psychology unit 38 under Frederic Bartlett, one of Bartlett’s last students and, for Gregory, one of his 39 most treasured mentors. -
Newsletter 8
Fellowship Newsletter 8 Clinical Academic Medicine in Jeopardy Recruitment is in crisis and those already following a time for research, and proposes clinical academic career are under pressure as never solutions for the particular before. The attraction of a career in difficulties experienced in craft clinical academic medicine is specialties such as surgery, fading and while the public anaesthetics, obstetrics and have strong expectations for gynaecology, radiology, and high medical standards and cardiology. rapid developments in health- Professor Sir Peter Morris FRS, care more than 10% of PRCS, FMedSci, chairman of professorial and senior lecturer the Academy working group posts remain unfilled and the that produced the report said at shortage of clinical research its launch ‘The situation for workers and clinical teachers academic medicine is becoming desperate espe- raises serious worries. cially for craft specialties such as surgery. The Academy’s latest report Concerted action by all the stakeholders - the Clinical academic medicine in Academy, government, the universities, the medical jeopardy, confronts these issues, royal colleges and others - is needed now, not only to demands urgent action to improve recruitment and produce the next generation of doctors but also to retention and spells out the consequences of inaction. maintain the translation of basic biological research into It makes practical suggestions for how this can be clinical practice in the UK’. achieved by addressing contractual and remuneration The report may be downloaded from the Academy’s issues, and appraisal and revalidation practices, and web site or paper copies obtained free from Tony Leaney improving career progress. It stresses the importance at the Academy. -
The Rhesus Factor and Disease Prevention
THE RHESUS FACTOR AND DISEASE PREVENTION The transcript of a Witness Seminar held by the Wellcome Trust Centre for the History of Medicine at UCL, London, on 3 June 2003 Edited by D T Zallen, D A Christie and E M Tansey Volume 22 2004 ©The Trustee of the Wellcome Trust, London, 2004 First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2004 The Wellcome Trust Centre for the History of Medicine at University College London is funded by the Wellcome Trust, which is a registered charity, no. 210183. ISBN 978 0 85484 099 1 Histmed logo images courtesy Wellcome Library, London. Design and production: Julie Wood at Shift Key Design 020 7241 3704 All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/ Please cite as : Zallen D T, Christie D A, Tansey E M. (eds) (2004) The Rhesus Factor and Disease Prevention. Wellcome Witnesses to Twentieth Century Medicine, vol. 22. London: Wellcome Trust Centre for the History of Medicine at UCL. CONTENTS Illustrations and credits v Witness Seminars: Meetings and publications;Acknowledgements vii E M Tansey and D A Christie Introduction Doris T Zallen xix Transcript Edited by D T Zallen, D A Christie and E M Tansey 1 References 61 Biographical notes 75 Glossary 85 Index 89 Key to cover photographs ILLUSTRATIONS AND CREDITS Figure 1 John Walker-Smith performs an exchange transfusion on a newborn with haemolytic disease. Photograph provided by Professor John Walker-Smith. Reproduced with permission of Memoir Club. 13 Figure 2 Radiograph taken on day after amniocentesis for bilirubin assessment and followed by contrast (1975). -
Bourne Lecture
“One Medicine: the Continuum of Medicine, Veterinary Medicine and Biomedical Science”. Bourne Lecture. 12th February 2007. St Georges Medical School , Grenada. Ian McConnell , Professor of Veterinary Science, Department of Veterinary Medicine, University of Cambridge, England, United Kingdom. Introduction. Chancellor, Provost , Ladies and Gentlemen. Thank you , Provost, for your generous introduction. It is indeed an honour to be invited to give this years Bourne lecture in memory of Geoffrey Bourne . Geoffrey Bourne , your first Vice Chancellor who as an educator and scientist who had the vision to create here in this marvellous country of Grenada a most remarkable medical school which later evolved under the leadership of Keith Taylor, as Vice Chancellor, into what is today- a thriving and confident young University. St George’s University is an internationally recognised institution of higher education which has set a dynamic global perspective and can rightly claim to be a stratgically important landmark of learning in the West Indies. In this lecture I am going to address the topic of “ One Medicine”. I have chosen this as a topic because it seems appropriate to the St. George’s Medical School and the close relationship it has with the veterinary school. The development of the veterinary school owes much to the foresight and drive of Peter Bourne, who as Vice Chancellor, fostered the development of veterinary medicine. In the long history of both the Medical and the Veterinary Professions and the education of undergraduates in both there has always been a healthy interaction between medicine, veterinary medicine as well as biomedical science. The co-location of a medical school with a veterinary school which you have here is one way to promote this interaction . -
PKU): Screening and Management
Consensus Development Conference on Phenylketonuria (PKU): Screening and Management October 16–18, 2000 William H. Natcher Conference Center National Institutes of Health Bethesda, Maryland Sponsored by: ¤ National Institute of Child Health and Human Development ¤ NIH Office of Medical Applications of Research ¤ Cosponsored by: ¤ National Human Genome Research Institute ¤ National Institute of Diabetes and Digestive and Kidney Diseases ¤ National Institute of Neurological Disorders and Stroke ¤ National Institute of Nursing Research ¤ NIH Office of Rare Diseases ¤ Maternal and Child Health Bureau of the Health Resources and Services Administration ¤ Contents Introduction......................................................................................................................................1 Agenda .............................................................................................................................................5 Panel Members...............................................................................................................................11 Speakers .........................................................................................................................................13 Planning Committee.......................................................................................................................15 Abstracts.........................................................................................................................................17 I. Overview Phenylketonuria: -
Genetic Testing
GENETIC TESTING The transcript of a Witness Seminar held by the Wellcome Trust Centre for the History of Medicine at UCL, London, on 13 July 2001 Edited by D A Christie and E M Tansey Volume 17 2003 CONTENTS Illustrations v Introduction Professor Peter Harper vii Acknowledgements ix Witness Seminars: Meetings and publications xi E M Tansey and D A Christie Transcript Edited by D A Christie and E M Tansey 1 References 73 Biographical notes 91 Glossary 105 Index 115 ILLUSTRATIONS Figure 1 Triploid cells in a human embryo, 1961. 20 Figure 2 The use of FISH with DNA probes from the X and Y chromosomes to sex human embryos. 62 v vi INTRODUCTION Genetic testing is now such a widespread and important part of medicine that it is hard to realize that it has almost all emerged during the past 30 years, with most of the key workers responsible for the discoveries and development of the field still living and active. This alone makes it a suitable subject for a Witness Seminar but there are others that increase its value, notably the fact that a high proportion of the critical advances took place in the UK; not just the basic scientific research, but also the initial applications in clinical practice, particularly those involving inherited disorders. To see these topics discussed by the people who were actually involved in their creation makes fascinating reading; for myself it is tinged with regret at having been unable to attend and contribute to the seminar, but with some compensation from being able to look at the contributions more objectively than can a participant. -
The Impact of NMR and MRI
WELLCOME WITNESSES TO TWENTIETH CENTURY MEDICINE _____________________________________________________________________________ MAKING THE HUMAN BODY TRANSPARENT: THE IMPACT OF NUCLEAR MAGNETIC RESONANCE AND MAGNETIC RESONANCE IMAGING _________________________________________________ RESEARCH IN GENERAL PRACTICE __________________________________ DRUGS IN PSYCHIATRIC PRACTICE ______________________ THE MRC COMMON COLD UNIT ____________________________________ WITNESS SEMINAR TRANSCRIPTS EDITED BY: E M TANSEY D A CHRISTIE L A REYNOLDS Volume Two – September 1998 ©The Trustee of the Wellcome Trust, London, 1998 First published by the Wellcome Trust, 1998 Occasional Publication no. 6, 1998 The Wellcome Trust is a registered charity, no. 210183. ISBN 978 186983 539 1 All volumes are freely available online at www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/ Please cite as : Tansey E M, Christie D A, Reynolds L A. (eds) (1998) Wellcome Witnesses to Twentieth Century Medicine, vol. 2. London: Wellcome Trust. Key Front cover photographs, L to R from the top: Professor Sir Godfrey Hounsfield, speaking (NMR) Professor Robert Steiner, Professor Sir Martin Wood, Professor Sir Rex Richards (NMR) Dr Alan Broadhurst, Dr David Healy (Psy) Dr James Lovelock, Mrs Betty Porterfield (CCU) Professor Alec Jenner (Psy) Professor David Hannay (GPs) Dr Donna Chaproniere (CCU) Professor Merton Sandler (Psy) Professor George Radda (NMR) Mr Keith (Tom) Thompson (CCU) Back cover photographs, L to R, from the top: Professor Hannah Steinberg, Professor -
Ian Gilmore Chair, UK Alcohol Health Alliance President, British Society of Gastroenterology Reflections on the ……
Ian Gilmore Chair, UK Alcohol Health Alliance President, British Society of Gastroenterology Reflections on the …… •challenges for hepatology •challenges for gastroenterology •challenges for the acute hospital •Challenges for the system •Challenges for society Challenges for hepatology Challenges for hepatology • Existing workforce (consultant, juniors, nurses • Recruitment into specialty • Relationship with gastroenterology • Relationship with G(I)M Challenges for gastroenterology Challenges for gastroenterology • Maintaining hepatology expertise • Relationships with ITU • 24/7 therapeutic endoscopy for bleeding • Repository for wider alcohol admissions? Quality and Productivity: Proven Case Study Alcohol Care Teams: reducing acute hospital admissions and improving quality of care Provided by: The British Society of Gastroenterology and Bolton NHS Foundation Trust Publication type: Quality and productivity example QIPP Evidence provides users with practical case studies that address the quality and productivity challenge in health and social care. All examples submitted are evaluated by NICE. This evaluation is based on the degree to which the initiative meets the QIPP criteria of savings, quality, evidence and implementability; each criterion is given a score which are then combined to give an overall score.r The overall score is used to identify the best examples, which ahn e then sow n or NHS Evidence as ‘eco mmended’. Our asseQIPPssment of the dforegree to walcoholhich this particular casecare study mee teamsts the criteria is represented in the evidence summary graphic below. Evidence summary Implementability Evidence of change Quality Savings 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100% Page 1 of 11 This document can be found online at: http://www.evidence.nhs.uk/qipp QIPP for alcohol care teams Challenges for the acute hospital Debate : is continuity now best delivered by a generalist ? Challenges for the system The new NHS – April 2013 Alcohol Related Admissions for Liverpool PCT (residents) 2002/03 to 2008/09 by Condition Group. -
Critical Care Decisions in Fetal and Neonatal Medicine: Ethical Issues Published by Nuffield Council on Bioethics 28 Bedford Square London WC1B 3JS
Critical care decisions in fetal and neonatal medicine: ethical issues Published by Nuffield Council on Bioethics 28 Bedford Square London WC1B 3JS Telephone: 020 7681 9619 Fax: 020 7637 1712 Email: [email protected] Website: http://www.nuffieldbioethics.org ISBN 1 904384 14 5 November 2006 To order a printed copy please contact the Nuffield Council on Bioethics or visit the website. © Nuffield Council on Bioethics 2006 All rights reserved. Apart from fair dealing for the purpose of private study, research, criticism or review, no part of the publication may be produced, stored in a retrieval system or transmitted in any form, or by any means, without prior permission of the copyright owners. Production management by: The Clyvedon Press Ltd 95 Maes-y-Sam Pentyrch Cardiff CF15 9QR Printed by: Latimer Trend & Company Ltd Estover Road Plymouth PL6 7PY Critical care decisions in fetal and neonatal medicine: ethical issues Nuffield Council on Bioethics Professor Sir Bob Hepple QC FBA (Chairman) Professor Peter Smith CBE (Deputy Chairman) Professor Margaret Brazier OBE* Professor Roger Brownsword Professor Sir Kenneth Calman KCB FRSE The Rt Rev Richard Harries DD FKC FRSL Professor Peter Harper Professor Søren Holm Mr Anatole Kaletsky Dr Rhona Knight Professor Sir John Krebs FRS* Professor Peter Lipton Professor Hugh Perry Professor Lord Plant of Highfield Dr Alan Williamson FRSE * co-opted members of the Council for the period of chairing the Working Parties on Critical care decisions in fetal and neonatal medicine: ethical issues