PDL Drug Class Review Announcement July 11, 2017

Drug Classes to be reviewed: Anticoagulants (Oral), Bone Resorption Suppression & Related Agents, Diabetes Management (Amylin, Biguanides, DPP‐4 Inhibitors, GLP‐1 Analogues, Hypoglycemic Combinations, Meglitinides, SGLT‐2 Inhibitors, Thiazolidinediones), Erythropoiesis Stimulating Agents, Hepatitis C Virus Treatments, Overactive Bladder Agents, Stimulants and other ADHD Agents, Colony Stimulating Factors, GI Motility (Chronic), and Ophthalmic Immunomodulators.

These drug classes will be reviewed at the July 11th, 2017 P&T Committee meeting from 1‐5pm. The location is 303 East 17th Avenue, Denver, CO 80203 11th Floor Conference Rooms. Dossiers and Supplemental Rebate offers are due to Magellan by May 31, 2017.

Please provide your public comments to Brad Robinson, Clinical Account Manager ([email protected]) no later than July 7, 2017 to ensure they are included in the information supplied to the P&T Committee members. Please carbon copy Brittany Schock, PDL Pharmacist ([email protected]) on all clinical information and public comment submissions.

ANTICOAGULANTS‐ ORAL Brand Name Generic Name

Coumadin Warfarin

Warfarin

Eliquis Apixaban

Pradaxa Dabigatran

Savaysa Edoxaban

Xarelto rivaroxaban

BONE RESORPTION SUPPRESSION & RELATED AGENTS Brand Name Generic Name

Calcitonin

Actonel Risedronate

Risedronate

Actonel with calcium Risedronate with calcium

Atelvia Risedronate

Risedronate

Binosto Alendronate

Boniva Ibandronate

Ibandronate

Didronel Etidronate

Etidronate

Evista Raloxifene

Raloxifene

Forteo Teriparatide

Fosamax Alendronate

Alendronate

Fosamax Plus D Alendronate with D

Fosamax solution Alendronate oral solution

Alendronate oral solution

Miacalcin Calcitonin

Calcitonin Prolia Denosumab

Tymlos Abaloparatide

COLONY STIMULATING FACTORS Brand Name Generic Name

Granix Flilgrastim

Leukine Sargramostim

Neulasta Pegfilgrastim

Neupogen Filgrastim

Zarxio* Filgrastim‐sndz

*biosimilar to Neupogen

DIABETES MANAGEMENT CLASSES: Amylin Brand Name Generic Name

Symlin Pramlintide

DIABETES MANAGEMENT CLASSES: Biguanides Brand Name Generic Name

Fortamet Metformin ER

Metformin ER

Glucophage Metformin Metformin

Glucophage XR Metformin ER

Metformin ER

Glumetza ER Metformin ER

Metformin ER

Riomet Metformin solution

DIABETES MANAGEMENT CLASSES: DPP‐4 Inhibitors Brand Name Generic Name

Januvia Sitagliptin

Nesina Alogliptin

Alogliptin

Onglyza Saxagliptin

Tradjenta Linagliptin

DIABETES MANAGEMENT CLASSES: GLP‐1 Analogues Brand Name Generic Name

Adlyxin Lixisenatide

Bydureon Exenatide

Byetta Exenatide

Tanzeum Albiglutide

Trulicity Dulaglutide

Victoza Liraglutide

DIABETES MANAGEMENT CLASSES: Hypoglycemic Combinations Brand Name Generic Name

Actoplus Met Pioglitazone/ metformin

Pioglitazone/ metformin

Actoplus Met XR Pioglitazone/ metformin ER

Duetact Pioglitazone/ glimepiride

Pioglitazone/ glimepiride

Glucovance Glyburide/ metformin

Glyburide/ metformin

Glyxambi Empagliflozin/ linagliptin

Invokamet Canagliflozin/ metformin

Invokamet XR Canagliflozin/ metformin ER

Janumet Sitagliptin/ metformin

Janumet XR Sitagliptin/ metformin ER

Jentadueto Linagliptin/ metformin

Jentadueto XR Linagliptin/ metformin ER

Kazano Alogliptin/ metformin

Alogliptin/ metformin

Kombiglyze XR Saxagliptin/ metformin ER

Metaglip Glipizide/ metformin

Glipizide/ metformin

Oseni Alogliptin/ pioglitazone

Alogliptin/ pioglitazone PrandiMet Repaglinide/ metformin

Repaglinide/ metformin

Soliqua Lixisenatide/ insulin glargine

Synjardy Empagliflozin/ metformin

Synjardy XR Empagliflozin/ metformin ER

Xigduo XR Dapagliflozin/ metformin ER

Xultophy Liraglutide/ insulin degludec

DIABETES MANAGEMENT CLASSES: Meglitinides Brand Name Generic Name

Prandin Repaglinide

Repaglinide

Starlix Nateglinide

Nateglinide

DIABETES MANAGEMENT CLASSES: SGLT‐2 Inhibitors Brand Name Generic Name

Farxiga Dapagliflozin

Invokana Canagliflozin

Jardiance Empagliflozin

DIABETES MANAGEMENT CLASSES: Thiazolidinediones Brand Name Generic Name

Actos Pioglitazone

Pioglitazone

Avandia Rosiglitazone

ERYTHROPOIESIS STIMULATING AGENTS Brand Name Generic Name

Aranesp Darbepoetin alfa

Epogen Epoetin alfa

Mircera Methoxy peg‐ epoetin beta

Procrit Epoetin alfa

GI MOTILITY, CHRONIC Brand Name Generic Name

Amitiza Lubiprostone

Linzess Linaclotide

Lotronex Alosetron

Alosetron

Movantik Naloxegol

Relistor Methylnaltrexone

Trulance Plecanatide

Viberzi Eluxadoline

HEPATITIS C VIRUS TREATMENTS Brand Name Generic Name

Daklinza daclatasvir

Epclusa sofosbuvir/ velpatasvir

Harvoni sofosbuvir/ ledipasvir

Olysio simeprevir

Sovaldi sofosbuvir

Technivie ombitasvir/ paritaprevir/ ritonavir

Viekira Pak ombitasvir/ paritaprevir/ ritonavir/ dasabuvir

Viekira XR ombitasvir/ paritaprevir/ ritonavir/ dasabuvir

Zepatier elbasvir/ grazoprevir

OPTHALMIC, IMMUNOMODULATORS Brand Name Generic Name

Restasis cyclosporine

Xiidra lifitegrast

OVERACTIVE BLADDER AGENTS Brand Name Generic Name

Flavoxate

Trospium

Trospium ER

Detrol Tolterodine

Tolterodine

Detrol LA Tolterodine ER

Tolterodine ER

Ditropan Oxybutynin

Oxybutynin

Ditropan XL Oxybutynin ER

Oxybutynin ER

Enablex Darifenacin

Darifenacin

Gelnique Oxybutynin gel

Myrbetriq Mirabegron

Oxytrol Oxybutynin patch

Toviaz Fesoterodine ER

Vesicare Solifenacin

STIMULANTS and other ADHD Agents Brand Name Generic Name

Adderall (tablet) Dextroamphetamine/ amphetamine

Dextroamphetamine/ amphetamine

Adderall XR (capsule) Dextroamphetamine/ amphetamine ER

Dextroamphetamine/ amphetamine ER

Adzenys XR ODT (OD tablet) Amphetamine ER

Aptensio XR (capsule) Methylphenidate ER

Concerta (tablet) Methylphenidate ER

Methylphenidate ER

Daytrana (patch) Methylphenidate patch

Desoxyn (tablet) Methamphetamine

Methamphetamine

Dexedrine (capsule, tablet) Dextroamphetamine

Dextroamphetamine

Dyanavel XR (suspension) Amphetamine suspension ER

Evekeo (tablet) Amphetamine

Focalin (tablet) Dexmethylphenidate

Dexmethylphenidate

Focalin XR (capsule) Dexmethylphenidate ER

Dexmethylphenidate ER

Intuniv (tablet) Guanfacine ER

Guanfacine ER Kapvay (tablet) Clonidine ER

Clonidine ER

Metadate CD (capsule) Methylphenidate ER

Methylphenidate ER

Metadate ER (tablet) Methylphenidate ER

Methylphenidate ER

Methylin (solution, tablet) Methylphenidate

Methylphenidate

Nuvigil (tablet) Armodafinil

Armodafinil

Procentra (solution) Dextroamphetamine solution

Dextroamphetamine solution

Provigil (tablet) Modafinil

Modafinil

Quillichew ER (chewable tablet) Methylphenidate ER

Quillivant XR (suspension) Methylphenidate ER

Ritalin (tablet) Methylphenidate

Methylphenidate

Ritalin LA (capsule) Methylphenidate ER

Methylphenidate ER

Ritalin SR (tablet) Methylphenidate ER

Methylphenidate ER Strattera (capsule) Atomoxetine

Vyvanse (capsule, chewable tablet) Lisdexamfetamine

Zenzedi (tablet) Dextroamphetamine